Yousang Gwack

Title(s)Department Vice Chair, Physiology
SchoolMedicine
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    Other Positions
    Title(s)Professor, Physiology


    Collapse Research 
    Collapse Research Activities and Funding
    Distinctive role of ORAI3 channels in the effector T cell response
    NIH R21AI149236Jun 1, 2020 - May 31, 2022
    Role: Principal Investigator
    Mechanism underlying regulation of Ca2+ signaling in local effector T cells
    NIH R01AI146615Mar 5, 2020 - Feb 28, 2025
    Role: Principal Investigator
    Role of Orai1 trafficking in local effector T cell responses
    NIH R56AI146615Aug 1, 2019 - Mar 4, 2020
    Role: Principal Investigator
    Development of an animal model of severe neutrophilic asthma
    NIH R03AI147063Jul 1, 2019 - Jun 30, 2021
    Role: Principal Investigator
    Role of histone demethylase Kdm3C in age-associated oral and systemic inflammation
    NIH R21DE028269Sep 4, 2018 - Aug 31, 2021
    Role: Co-Principal Investigator
    The function of CRAC channels in airway inflammation
    NIH R21AI109059Jan 1, 2016 - Dec 31, 2017
    Role: Principal Investigator
    A new class of immunomodulator, CRAC channel blockers
    NIH R21AI101569Jul 1, 2012 - Jun 30, 2014
    Role: Principal Investigator
    Suppression of Immune Functions by a Peptide Blocking Function of CRAC Channels
    NIH R21AI088393May 15, 2010 - Apr 30, 2013
    Role: Principal Investigator
    Novel lymphocyte-specific Rab GTPase in T cell differentiation
    NIH R01AI083432Jul 1, 2009 - Oct 31, 2021
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Orai inhibition modulates pulmonary ILC2 metabolism and alleviates airway hyperreactivity in murine and humanized models. Nat Commun. 2023 Sep 26; 14(1):5989. Howard E, Hurrell BP, Helou DG, Shafiei-Jahani P, Hasiakos S, Painter J, Srikanth S, Gwack Y, Akbari O. PMID: 37752127; PMCID: PMC10522697.
      View in: PubMed   Mentions:    Fields:    
    2. Orai3 Calcium Channel Contributes to Oral/Oropharyngeal Cancer Stemness through the Elevation of ID1 Expression. Cells. 2023 09 07; 12(18). Nguyen A, Sung Y, Lee SH, Martin CE, Srikanth S, Chen W, Kang MK, Kim RH, Park NH, Gwack Y, Kim Y, Shin KH. PMID: 37759448; PMCID: PMC10527097.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. SRC2 controls CD4+ T cell activation via stimulating c-Myc-mediated upregulation of amino acid transporter Slc7a5. Proc Natl Acad Sci U S A. 2023 05 02; 120(18):e2221352120. Zhang W, Cao X, Zhong X, Wu H, Shi Y, Feng M, Wang YC, Ann D, Gwack Y, Yuan YC, Shang W, Sun Z. PMID: 37094160; PMCID: PMC10160970.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. Decoupling the role of RORγt in the differentiation and effector function of TH17 cells. Sci Adv. 2022 Oct 21; 8(42):eadc9221. Zhong X, Wu H, Zhang W, Gwack Y, Shang W, Lee KO, Isakov N, He Z, Sun Z. PMID: 36269826; PMCID: PMC9586477.
      View in: PubMed   Mentions: 1     Fields:    
    5. Steroid nuclear receptor coactivator 2 controls immune tolerance by promoting induced Treg differentiation via up-regulating Nr4a2. Sci Adv. 2022 06 17; 8(24):eabn7662. Zhang W, Cao X, Zhong X, Wu H, Feng M, Gwack Y, Isakov N, Sun Z. PMID: 35704583; PMCID: PMC9200286.
      View in: PubMed   Mentions: 2     Fields:    
    6. Long-Term Ligature-Induced Periodontitis Exacerbates Development of Bisphosphonate-Related Osteonecrosis of the Jaw in Mice. J Bone Miner Res. 2022 07; 37(7):1400-1410. Williams DW, Ho K, Lenon A, Kim S, Kim T, Gwack Y, Kim RH. PMID: 35598324; PMCID: PMC9386631.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    7. Ca2+ Signaling Augmented by ORAI1 Trafficking Regulates the Pathogenic State of Effector T Cells. J Immunol. 2022 03 15; 208(6):1329-1340. Wu B, Woo JS, Sun Z, Srikanth S, Gwack Y. PMID: 35217583; PMCID: PMC8916982.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    8. Biallelic mutations in calcium release activated channel regulator 2A (CRACR2A) cause a primary immunodeficiency disorder. Elife. 2021 12 15; 10. Wu B, Rice L, Shrimpton J, Lawless D, Walker K, Carter C, McKeown L, Anwar R, Doody GM, Srikanth S, Gwack Y, Savic S. PMID: 34908525; PMCID: PMC8673834.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    9. Insulin-activated store-operated Ca2+ entry via Orai1 induces podocyte actin remodeling and causes proteinuria. Nat Commun. 2021 11 11; 12(1):6537. Kim JH, Hwang KH, Dang BTN, Eom M, Kong ID, Gwack Y, Yu S, Gee HY, Birnbaumer L, Park KS, Cha SK. PMID: 34764278; PMCID: PMC8586150.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    10. NKD2 mediates stimulation-dependent ORAI1 trafficking to augment Ca2+ entry in T cells. Cell Rep. 2021 08 24; 36(8):109603. Wu B, Woo JS, Vila P, Jew M, Leung J, Sun Z, Srikanth S, Gwack Y. PMID: 34433025; PMCID: PMC8435239.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    11. ORAI1 establishes resistance to SARS-CoV-2 infection by regulating tonic type I interferon signaling. bioRxiv. 2021 May 04. Wu B, Ramaiah A, Garcia G, Gwack Y, Arumugaswami V, Srikanth S. PMID: 33972946; PMCID: PMC8109209.
      View in: PubMed   Mentions:
    12. Blue light opens the ORAI1 LOC(K). Cell Calcium. 2021 05; 95:102371. Srikanth S, Gwack Y. PMID: 33626404.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    13. Calcium Signaling in T Cells and Chronic Inflammatory Disorders of the Oral Cavity. J Dent Res. 2021 07; 100(7):693-699. Hasiakos S, Gwack Y, Kang M, Nishimura I. PMID: 33541200; PMCID: PMC8221706.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    14. The short isoform of extended synaptotagmin-2 controls Ca2+ dynamics in T cells via interaction with STIM1. Sci Rep. 2020 09 02; 10(1):14433. Woo JS, Sun Z, Srikanth S, Gwack Y. PMID: 32879390; PMCID: PMC7468131.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    15. Histone Lys demethylase KDM3C demonstrates anti-inflammatory effects by suppressing NF-κB signaling and osteoclastogenesis. FASEB J. 2019 09; 33(9):10515-10527. Lee JY, Mehrazarin S, Alshaikh A, Kim S, Chen W, Lux R, Gwack Y, Kim RH, Kang MK. PMID: 31251083; PMCID: PMC6704463.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    16. Correction: CRACR2A-Mediated TCR Signaling Promotes Local Effector Th1 and Th17 Responses. J Immunol. 2019 Jul 01; 203(1):293. Woo JS, Srikanth S, Kim KD, Elsaesser H, Lu J, Pellegrini M, Brooks DG, Sun Z, Gwack Y. PMID: 31127031.
      View in: PubMed   Mentions:    Fields:    
    17. A Report of Novel STIM1 Deficiency and 6-Year Follow-Up of Two Previous Cases Associated with Mild Immunological Phenotype. J Clin Immunol. 2019 04; 39(3):249-256. Rice L, Stockdale C, Berry I, O'Riordan S, Pysden K, Anwar R, Rushambuza R, Blyth M, Srikanth S, Gwack Y, El-Sherbiny YM, Carter C, Savic S. PMID: 30949876.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    18. The Ca2+ sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum. Nat Immunol. 2019 02; 20(2):152-162. Srikanth S, Woo JS, Wu B, El-Sherbiny YM, Leung J, Chupradit K, Rice L, Seo GJ, Calmettes G, Ramakrishna C, Cantin E, An DS, Sun R, Wu TT, Jung JU, Savic S, Gwack Y. PMID: 30643259; PMCID: PMC6340781.
      View in: PubMed   Mentions: 129     Fields:    Translation:HumansAnimalsCells
    19. SRC3 Is a Cofactor for RORγt in Th17 Differentiation but Not Thymocyte Development. J Immunol. 2019 02 01; 202(3):760-769. He Z, Zhang J, Du Q, Xu J, Gwack Y, Sun Z. PMID: 30567733; PMCID: PMC6344289.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    20. CRACR2A-Mediated TCR Signaling Promotes Local Effector Th1 and Th17 Responses. J Immunol. 2018 08 15; 201(4):1174-1185. Woo JS, Srikanth S, Kim KD, Elsaesser H, Lu J, Pellegrini M, Brooks DG, Sun Z, Gwack Y. PMID: 29987160; PMCID: PMC6081249.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    21. Deletion of Orai1 leads to bone loss aggravated with aging and impairs function of osteoblast lineage cells. Bone Rep. 2018 Jun; 8:147-155. Choi H, Srikanth S, Atti E, Pirih FQ, Nervina JM, Gwack Y, Tetradis S. PMID: 29955633; PMCID: PMC6020256.
      View in: PubMed   Mentions: 10  
    22. SRC1 promotes Th17 differentiation by overriding Foxp3 suppression to stimulate RORγt activity in a PKC-θ-dependent manner. Proc Natl Acad Sci U S A. 2018 01 16; 115(3):E458-E467. Sen S, Wang F, Zhang J, He Z, Ma J, Gwack Y, Xu J, Sun Z. PMID: 29282318; PMCID: PMC5776998.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    23. Regulation of Th17 Differentiation by IKKα-Dependent and -Independent Phosphorylation of RORγt. J Immunol. 2017 08 01; 199(3):955-964. He Z, Wang F, Zhang J, Sen S, Pang Q, Luo S, Gwack Y, Sun Z. PMID: 28667162; PMCID: PMC5531059.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    24. Laminar flow downregulates Notch activity to promote lymphatic sprouting. J Clin Invest. 2017 Apr 03; 127(4):1225-1240. Choi D, Park E, Jung E, Seong YJ, Yoo J, Lee E, Hong M, Lee S, Ishida H, Burford J, Peti-Peterdi J, Adams RH, Srikanth S, Gwack Y, Chen CS, Vogel HJ, Koh CJ, Wong AK, Hong YK. PMID: 28263185; PMCID: PMC5373895.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    25. ORAI1 Activates Proliferation of Lymphatic Endothelial Cells in Response to Laminar Flow Through Krüppel-Like Factors 2 and 4. Circ Res. 2017 Apr 28; 120(9):1426-1439. Choi D, Park E, Jung E, Seong YJ, Hong M, Lee S, Burford J, Gyarmati G, Peti-Peterdi J, Srikanth S, Gwack Y, Koh CJ, Boriushkin E, Hamik A, Wong AK, Hong YK. PMID: 28167653; PMCID: PMC6300148.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    26. Immunological Disorders: Regulation of Ca2+ Signaling in T Lymphocytes. Adv Exp Med Biol. 2017; 993:397-424. Srikanth S, Woo JS, Sun Z, Gwack Y. PMID: 28900926; PMCID: PMC8957800.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    27. Ubiquitination of RORγt at Lysine 446 Limits Th17 Differentiation by Controlling Coactivator Recruitment. J Immunol. 2016 08 15; 197(4):1148-58. He Z, Wang F, Ma J, Sen S, Zhang J, Gwack Y, Zhou Y, Sun Z. PMID: 27430721; PMCID: PMC4976012.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    28. Orai1 promotes tumor progression by enhancing cancer stemness via NFAT signaling in oral/oropharyngeal squamous cell carcinoma. Oncotarget. 2016 Jul 12; 7(28):43239-43255. Lee SH, Rigas NK, Lee CR, Bang A, Srikanth S, Gwack Y, Kang MK, Kim RH, Park NH, Shin KH. PMID: 27259269; PMCID: PMC5190020.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    29. A large Rab GTPase family in a small GTPase world. Small GTPases. 2017 01 02; 8(1):43-48. Srikanth S, Woo JS, Gwack Y. PMID: 27221160; PMCID: PMC5331893.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    30. Orai1 mediates osteogenic differentiation via BMP signaling pathway in bone marrow mesenchymal stem cells. Biochem Biophys Res Commun. 2016 05 13; 473(4):1309-1314. Lee SH, Park Y, Song M, Srikanth S, Kim S, Kang MK, Gwack Y, Park NH, Kim RH, Shin KH. PMID: 27086849; PMCID: PMC4853278.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    31. A large Rab GTPase encoded by CRACR2A is a component of subsynaptic vesicles that transmit T cell activation signals. Sci Signal. 2016 Mar 22; 9(420):ra31. Srikanth S, Kim KD, Gao Y, Woo JS, Ghosh S, Calmettes G, Paz A, Abramson J, Jiang M, Gwack Y. PMID: 27016526; PMCID: PMC5013727.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    32. Junctophilin-4, a component of the endoplasmic reticulum-plasma membrane junctions, regulates Ca2+ dynamics in T cells. Proc Natl Acad Sci U S A. 2016 Mar 08; 113(10):2762-7. Woo JS, Srikanth S, Nishi M, Ping P, Takeshima H, Gwack Y. PMID: 26929330; PMCID: PMC4790987.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    33. Dental enamel cells express functional SOCE channels. Sci Rep. 2015 Oct 30; 5:15803. Nurbaeva MK, Eckstein M, Concepcion AR, Smith CE, Srikanth S, Paine ML, Gwack Y, Hubbard MJ, Feske S, Lacruz RS. PMID: 26515404; PMCID: PMC4626795.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    34. The Role of ORAI1 in the Odontogenic Differentiation of Human Dental Pulp Stem Cells. J Dent Res. 2015 Nov; 94(11):1560-7. Sohn S, Park Y, Srikanth S, Arai A, Song M, Yu B, Shin KH, Kang MK, Wang C, Gwack Y, Park NH, Kim RH. PMID: 26403672; PMCID: PMC4622325.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    35. The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4⁺ T cells. Nat Immunol. 2014 Nov; 15(11):1055-1063. Bertin S, Aoki-Nonaka Y, de Jong PR, Nohara LL, Xu H, Stanwood SR, Srikanth S, Lee J, To K, Abramson L, Yu T, Han T, Touma R, Li X, González-Navajas JM, Herdman S, Corr M, Fu G, Dong H, Gwack Y, Franco A, Jefferies WA, Raz E. PMID: 25282159; PMCID: PMC4843825.
      View in: PubMed   Mentions: 106     Fields:    Translation:HumansAnimalsCells
    36. Interplay between the oxidoreductase PDIA6 and microRNA-322 controls the response to disrupted endoplasmic reticulum calcium homeostasis. Sci Signal. 2014 Jun 10; 7(329):ra54. Groenendyk J, Peng Z, Dudek E, Fan X, Mizianty MJ, Dufey E, Urra H, Sepulveda D, Rojas-Rivera D, Lim Y, Kim DH, Baretta K, Srikanth S, Gwack Y, Ahnn J, Kaufman RJ, Lee SK, Hetz C, Kurgan L, Michalak M. PMID: 24917591; PMCID: PMC4984425.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    37. Methods to measure cytoplasmic and mitochondrial Ca(2+) concentration using Ca(2+)-sensitive dyes. Methods Enzymol. 2014; 543:1-20. Srikanth S, Kim KD, Gwack Y. PMID: 24924125.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    38. Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation. J Immunol. 2014 Jan 01; 192(1):110-22. Kim KD, Srikanth S, Tan YV, Yee MK, Jew M, Damoiseaux R, Jung ME, Shimizu S, An DS, Ribalet B, Waschek JA, Gwack Y. PMID: 24307733; PMCID: PMC3874217.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    39. Orai1-NFAT signalling pathway triggered by T cell receptor stimulation. Mol Cells. 2013 Mar; 35(3):182-94. Srikanth S, Gwack Y. PMID: 23483280; PMCID: PMC3887911.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    40. Regulation of CRAC channels by protein interactions and post-translational modification. Channels (Austin). 2013 Sep-Oct; 7(5):354-63. Srikanth S, Ribalet B, Gwack Y. PMID: 23454861; PMCID: PMC3893732.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    41. Measurement of intracellular Ca2+ concentration in single cells using ratiometric calcium dyes. Methods Mol Biol. 2013; 963:3-14. Srikanth S, Gwack Y. PMID: 23296601.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    42. Molecular regulation of the pore component of CRAC channels, Orai1. Curr Top Membr. 2013; 71:181-207. Srikanth S, Gwack Y. PMID: 23890116.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    43. Orai1, STIM1, and their associating partners. J Physiol. 2012 Sep 01; 590(17):4169-77. Srikanth S, Gwack Y. PMID: 22586216; PMCID: PMC3473276.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    44. Junctate is a Ca2+-sensing structural component of Orai1 and stromal interaction molecule 1 (STIM1). Proc Natl Acad Sci U S A. 2012 May 29; 109(22):8682-7. Srikanth S, Jew M, Kim KD, Yee MK, Abramson J, Gwack Y. PMID: 22586105; PMCID: PMC3365170.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    45. ORAI1 deficiency impairs activated T cell death and enhances T cell survival. J Immunol. 2011 Oct 01; 187(7):3620-30. Kim KD, Srikanth S, Yee MK, Mock DC, Lawson GW, Gwack Y. PMID: 21873530; PMCID: PMC3178683.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    46. The third transmembrane segment of orai1 protein modulates Ca2+ release-activated Ca2+ (CRAC) channel gating and permeation properties. J Biol Chem. 2011 Oct 07; 286(40):35318-28. Srikanth S, Yee MK, Gwack Y, Ribalet B. PMID: 21865174; PMCID: PMC3186358.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    47. Protein kinase D orchestrates the activation of DRAK2 in response to TCR-induced Ca2+ influx and mitochondrial reactive oxygen generation. J Immunol. 2011 Jan 15; 186(2):940-50. Newton RH, Leverrier S, Srikanth S, Gwack Y, Cahalan MD, Walsh CM. PMID: 21148796; PMCID: PMC3133617.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    48. A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells. Nat Cell Biol. 2010 May; 12(5):436-46. Srikanth S, Jung HJ, Kim KD, Souda P, Whitelegge J, Gwack Y. PMID: 20418871; PMCID: PMC2875865.
      View in: PubMed   Mentions: 121     Fields:    Translation:HumansCells
    49. The intracellular loop of Orai1 plays a central role in fast inactivation of Ca2+ release-activated Ca2+ channels. J Biol Chem. 2010 Feb 12; 285(7):5066-75. Srikanth S, Jung HJ, Ribalet B, Gwack Y. PMID: 20007711; PMCID: PMC2836109.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    50. Viral Bcl-2-mediated evasion of autophagy aids chronic infection of gammaherpesvirus 68. PLoS Pathog. 2009 Oct; 5(10):e1000609. E X, Hwang S, Oh S, Lee JS, Jeong JH, Gwack Y, Kowalik TF, Sun R, Jung JU, Liang C. PMID: 19816569; PMCID: PMC2752191.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    51. Hair loss and defective T- and B-cell function in mice lacking ORAI1. Mol Cell Biol. 2008 Sep; 28(17):5209-22. Gwack Y, Srikanth S, Oh-Hora M, Hogan PG, Lamperti ED, Yamashita M, Gelinas C, Neems DS, Sasaki Y, Feske S, Prakriya M, Rajewsky K, Rao A. PMID: 18591248; PMCID: PMC2519726.
      View in: PubMed   Mentions: 172     Fields:    Translation:AnimalsCells
    52. Dynamic movement of the calcium sensor STIM1 and the calcium channel Orai1 in activated T-cells: puncta and distal caps. Mol Biol Cell. 2008 Jul; 19(7):2802-17. Barr VA, Bernot KM, Srikanth S, Gwack Y, Balagopalan L, Regan CK, Helman DJ, Sommers CL, Oh-Hora M, Rao A, Samelson LE. PMID: 18448669; PMCID: PMC2441672.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansCells
    53. Signalling to transcription: store-operated Ca2+ entry and NFAT activation in lymphocytes. Cell Calcium. 2007 Aug; 42(2):145-56. Gwack Y, Feske S, Srikanth S, Hogan PG, Rao A. PMID: 17572487.
      View in: PubMed   Mentions: 152     Fields:    Translation:HumansAnimalsCells
    54. Biochemical and functional characterization of Orai proteins. J Biol Chem. 2007 Jun 01; 282(22):16232-43. Gwack Y, Srikanth S, Feske S, Cruz-Guilloty F, Oh-hora M, Neems DS, Hogan PG, Rao A. PMID: 17293345.
      View in: PubMed   Mentions: 202     Fields:    Translation:HumansAnimalsCells
    55. Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated calcium influx. Evidence for similarities in store-operated and calcium release-activated calcium channel components. J Biol Chem. 2007 Mar 23; 282(12):9105-16. Ong HL, Cheng KT, Liu X, Bandyopadhyay BC, Paria BC, Soboloff J, Pani B, Gwack Y, Srikanth S, Singh BB, Gill DL, Gill D, Ambudkar IS. PMID: 17224452; PMCID: PMC3309402.
      View in: PubMed   Mentions: 172     Fields:    Translation:HumansAnimalsCells
    56. Orai1 is an essential pore subunit of the CRAC channel. Nature. 2006 Sep 14; 443(7108):230-3. Prakriya M, Feske S, Gwack Y, Srikanth S, Rao A, Hogan PG. PMID: 16921383.
      View in: PubMed   Mentions: 633     Fields:    Translation:HumansCells
    57. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature. 2006 May 11; 441(7090):179-85. Feske S, Gwack Y, Prakriya M, Srikanth S, Puppel SH, Tanasa B, Hogan PG, Lewis RS, Daly M, Rao A. PMID: 16582901.
      View in: PubMed   Mentions: 1059     Fields:    Translation:HumansAnimalsCells
    58. A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT. Nature. 2006 Jun 01; 441(7093):646-50. Gwack Y, Sharma S, Nardone J, Tanasa B, Iuga A, Srikanth S, Okamura H, Bolton D, Feske S, Hogan PG, Rao A. PMID: 16511445.
      View in: PubMed   Mentions: 176     Fields:    Translation:AnimalsCells
    59. Activation of CD21 and CD23 gene expression by Kaposi's sarcoma-associated herpesvirus RTA. J Virol. 2005 Apr; 79(8):4651-63. Chang H, Gwack Y, Kingston D, Souvlis J, Liang X, Means RE, Cesarman E, Hutt-Fletcher L, Jung JU. PMID: 15795251; PMCID: PMC1069543.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    60. Modulation of T-cell receptor signal transduction by herpesvirus signaling adaptor protein. Mol Cell Biol. 2004 Jun; 24(12):5369-82. Lee SH, Chung YH, Cho NH, Gwack Y, Feng P, Jung JU. PMID: 15169900; PMCID: PMC419894.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    61. Poly(ADP-ribose) polymerase 1 and Ste20-like kinase hKFC act as transcriptional repressors for gamma-2 herpesvirus lytic replication. Mol Cell Biol. 2003 Nov; 23(22):8282-94. Gwack Y, Nakamura H, Lee SH, Souvlis J, Yustein JT, Gygi S, Kung HJ, Jung JU. PMID: 14585985; PMCID: PMC262387.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansCells
    62. Global changes in Kaposi's sarcoma-associated virus gene expression patterns following expression of a tetracycline-inducible Rta transactivator. J Virol. 2003 Apr; 77(7):4205-20. Nakamura H, Lu M, Gwack Y, Souvlis J, Zeichner SL, Jung JU. PMID: 12634378; PMCID: PMC150665.
      View in: PubMed   Mentions: 204     Fields:    Translation:HumansCells
    63. Principal role of TRAP/mediator and SWI/SNF complexes in Kaposi's sarcoma-associated herpesvirus RTA-mediated lytic reactivation. Mol Cell Biol. 2003 Mar; 23(6):2055-67. Gwack Y, Baek HJ, Nakamura H, Lee SH, Meisterernst M, Roeder RG, Jung JU. PMID: 12612078; PMCID: PMC149486.
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    64. Kaposi's sarcoma-associated herpesvirus K8 protein interacts with hSNF5. J Gen Virol. 2003 Mar; 84(Pt 3):665-676. Hwang S, Lee D, Gwack Y, Min H, Choe J. PMID: 12604819.
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    65. Functional dissection of latency-associated nuclear antigen 1 of Kaposi's sarcoma-associated herpesvirus involved in latent DNA replication and transcription of terminal repeats of the viral genome. J Virol. 2002 Oct; 76(20):10320-31. Lim C, Sohn H, Lee D, Gwack Y, Choe J. PMID: 12239308; PMCID: PMC136563.
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    66. Kaposi's Sarcoma-associated herpesvirus open reading frame 50 stimulates the transcriptional activity of STAT3. J Biol Chem. 2002 Feb 22; 277(8):6438-42. Gwack Y, Hwang S, Lim C, Won YS, Lee CH, Choe J. PMID: 11741976.
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    67. The transcriptional activity of cAMP response element-binding protein-binding protein is modulated by the latency associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus. J Biol Chem. 2001 Aug 17; 276(33):31016-22. Lim C, Gwack Y, Hwang S, Kim S, Choe J. PMID: 11425857.
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    68. CREB-binding protein and histone deacetylase regulate the transcriptional activity of Kaposi's sarcoma-associated herpesvirus open reading frame 50. J Virol. 2001 Feb; 75(4):1909-17. Gwack Y, Byun H, Hwang S, Lim C, Choe J. PMID: 11160690; PMCID: PMC115137.
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    69. The K-bZIP protein from Kaposi's sarcoma-associated herpesvirus interacts with p53 and represses its transcriptional activity. J Virol. 2000 Dec; 74(24):11977-82. Park J, Seo T, Hwang S, Lee D, Gwack Y, Choe J. PMID: 11090200; PMCID: PMC112483.
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    70. Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) binds ATF4/CREB2 and inhibits its transcriptional activation activity. J Gen Virol. 2000 Nov; 81(Pt 11):2645-2652. Lim C, Sohn H, Gwack Y, Choe J. PMID: 11038375.
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    71. RNA-Stimulated ATPase and RNA helicase activities and RNA binding domain of hepatitis G virus nonstructural protein 3. J Virol. 1999 Apr; 73(4):2909-15. Gwack Y, Yoo H, Song I, Choe J, Han JH. PMID: 10074139; PMCID: PMC104049.
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    72. Mutational analysis of the hepatitis C virus RNA helicase. J Virol. 1997 Dec; 71(12):9400-9. Kim DW, Kim J, Gwack Y, Han JH, Choe J. PMID: 9371600; PMCID: PMC230244.
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    73. DNA helicase activity of the hepatitis C virus nonstructural protein 3. Eur J Biochem. 1997 Nov 15; 250(1):47-54. Gwack Y, Kim DW, Han JH, Choe J. PMID: 9431989.
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    74. Towards defining a minimal functional domain for NTPase and RNA helicase activities of the hepatitis C virus NS3 protein. Virus Res. 1997 May; 49(1):17-25. Kim DW, Gwack Y, Han JH, Choe J. PMID: 9178493.
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    75. Characterization of RNA binding activity and RNA helicase activity of the hepatitis C virus NS3 protein. Biochem Biophys Res Commun. 1996 Aug 14; 225(2):654-9. Gwack Y, Kim DW, Han JH, Choe J. PMID: 8753814.
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    76. C-terminal domain of the hepatitis C virus NS3 protein contains an RNA helicase activity. Biochem Biophys Res Commun. 1995 Oct 04; 215(1):160-6. Kim DW, Gwack Y, Han JH, Choe J. PMID: 7575585.
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