Yousang Gwack
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Title(s) | Professor, Physiology |
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School | Medicine |
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Address | 760 Westwood Plaza 53-231 Los Angeles CA 90024
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Phone | 3107942003 |
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vCard | Download vCard |
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Research Bibliographic
Altmetrics Details
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media.
(Note that publications are often cited in additional ways that are not shown here.)
Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
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Click a Field or Translation tag to filter the publications.
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The short isoform of extended synaptotagmin-2 controls Ca2+ dynamics in T cells via interaction with STIM1. Sci Rep. 2020 09 02; 10(1):14433.
Woo JS, Sun Z, Srikanth S, Gwack Y. PMID: 32879390.
View in: PubMed Mentions: Fields:
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Histone Lys demethylase KDM3C demonstrates anti-inflammatory effects by suppressing NF-κB signaling and osteoclastogenesis. FASEB J. 2019 09; 33(9):10515-10527.
Lee JY, Mehrazarin S, Alshaikh A, Kim S, Chen W, Lux R, Gwack Y, Kim RH, Kang MK. PMID: 31251083.
View in: PubMed Mentions: 5 Fields: Translation: HumansAnimalsCells
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Correction: CRACR2A-Mediated TCR Signaling Promotes Local Effector Th1 and Th17 Responses. J Immunol. 2019 Jul 01; 203(1):293.
Woo JS, Srikanth S, Kim KD, Elsaesser H, Lu J, Pellegrini M, Brooks DG, Sun Z, Gwack Y. PMID: 31127031.
View in: PubMed Mentions: Fields:
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A Report of Novel STIM1 Deficiency and 6-Year Follow-Up of Two Previous Cases Associated with Mild Immunological Phenotype. J Clin Immunol. 2019 04; 39(3):249-256.
Rice L, Stockdale C, Berry I, O'Riordan S, Pysden K, Anwar R, Rushambuza R, Blyth M, Srikanth S, Gwack Y, El-Sherbiny YM, Carter C, Savic S. PMID: 30949876.
View in: PubMed Mentions: 1 Fields: Translation: HumansCells
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The Ca2+ sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum. Nat Immunol. 2019 02; 20(2):152-162.
Srikanth S, Woo JS, Wu B, El-Sherbiny YM, Leung J, Chupradit K, Rice L, Seo GJ, Calmettes G, Ramakrishna C, Cantin E, An DS, Sun R, Wu TT, Jung JU, Savic S, Gwack Y. PMID: 30643259.
View in: PubMed Mentions: 37 Fields: Translation: HumansAnimalsCells
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CRACR2A-Mediated TCR Signaling Promotes Local Effector Th1 and Th17 Responses. J Immunol. 2018 08 15; 201(4):1174-1185.
Woo JS, Srikanth S, Kim KD, Elsaesser H, Lu J, Pellegrini M, Brooks DG, Sun Z, Gwack Y. PMID: 29987160.
View in: PubMed Mentions: 3 Fields: Translation: HumansAnimalsCells
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Deletion of Orai1 leads to bone loss aggravated with aging and impairs function of osteoblast lineage cells. Bone Rep. 2018 Jun; 8:147-155.
Choi H, Srikanth S, Atti E, Pirih FQ, Nervina JM, Gwack Y, Tetradis S. PMID: 29955633.
View in: PubMed Mentions:
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Laminar flow downregulates Notch activity to promote lymphatic sprouting. J Clin Invest. 2017 Apr 03; 127(4):1225-1240.
Choi D, Park E, Jung E, Seong YJ, Yoo J, Lee E, Hong M, Lee S, Ishida H, Burford J, Peti-Peterdi J, Adams RH, Srikanth S, Gwack Y, Chen CS, Vogel HJ, Koh CJ, Wong AK, Hong YK. PMID: 28263185.
View in: PubMed Mentions: 28 Fields: Translation: HumansAnimalsCells
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ORAI1 Activates Proliferation of Lymphatic Endothelial Cells in Response to Laminar Flow Through Krüppel-Like Factors 2 and 4. Circ Res. 2017 Apr 28; 120(9):1426-1439.
Choi D, Park E, Jung E, Seong YJ, Hong M, Lee S, Burford J, Gyarmati G, Peti-Peterdi J, Srikanth S, Gwack Y, Koh CJ, Boriushkin E, Hamik A, Wong AK, Hong YK. PMID: 28167653.
View in: PubMed Mentions: 13 Fields: Translation: HumansAnimalsCells
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Immunological Disorders: Regulation of Ca2+ Signaling in T Lymphocytes. Adv Exp Med Biol. 2017; 993:397-424.
Srikanth S, Woo JS, Sun Z, Gwack Y. PMID: 28900926.
View in: PubMed Mentions: 5 Fields: Translation: HumansAnimalsCells
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Orai1 promotes tumor progression by enhancing cancer stemness via NFAT signaling in oral/oropharyngeal squamous cell carcinoma. Oncotarget. 2016 Jul 12; 7(28):43239-43255.
Lee SH, Rigas NK, Lee CR, Bang A, Srikanth S, Gwack Y, Kang MK, Kim RH, Park NH, Shin KH. PMID: 27259269.
View in: PubMed Mentions: 6 Fields: Translation: HumansAnimalsCells
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A large Rab GTPase family in a small GTPase world. Small GTPases. 2017 01 02; 8(1):43-48.
Srikanth S, Woo JS, Gwack Y. PMID: 27221160.
View in: PubMed Mentions: 8 Fields: Translation: HumansAnimalsCells
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Orai1 mediates osteogenic differentiation via BMP signaling pathway in bone marrow mesenchymal stem cells. Biochem Biophys Res Commun. 2016 05 13; 473(4):1309-1314.
Lee SH, Park Y, Song M, Srikanth S, Kim S, Kang MK, Gwack Y, Park NH, Kim RH, Shin KH. PMID: 27086849.
View in: PubMed Mentions: 6 Fields: Translation: AnimalsCells
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A large Rab GTPase encoded by CRACR2A is a component of subsynaptic vesicles that transmit T cell activation signals. Sci Signal. 2016 Mar 22; 9(420):ra31.
Srikanth S, Kim KD, Gao Y, Woo JS, Ghosh S, Calmettes G, Paz A, Abramson J, Jiang M, Gwack Y. PMID: 27016526.
View in: PubMed Mentions: 11 Fields: Translation: HumansAnimalsCells
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Junctophilin-4, a component of the endoplasmic reticulum-plasma membrane junctions, regulates Ca2+ dynamics in T cells. Proc Natl Acad Sci U S A. 2016 Mar 08; 113(10):2762-7.
Woo JS, Srikanth S, Nishi M, Ping P, Takeshima H, Gwack Y. PMID: 26929330.
View in: PubMed Mentions: 14 Fields: Translation: HumansAnimalsCells
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Dental enamel cells express functional SOCE channels. Sci Rep. 2015 Oct 30; 5:15803.
Nurbaeva MK, Eckstein M, Concepcion AR, Smith CE, Srikanth S, Paine ML, Gwack Y, Hubbard MJ, Feske S, Lacruz RS. PMID: 26515404.
View in: PubMed Mentions: 13 Fields: Translation: HumansAnimalsCells
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The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4? T cells. Nat Immunol. 2014 Nov; 15(11):1055-1063.
Bertin S, Aoki-Nonaka Y, de Jong PR, Nohara LL, Xu H, Stanwood SR, Srikanth S, Lee J, To K, Abramson L, Yu T, Han T, Touma R, Li X, González-Navajas JM, Herdman S, Corr M, Fu G, Dong H, Gwack Y, Franco A, Jefferies WA, Raz E. PMID: 25282159.
View in: PubMed Mentions: 53 Fields: Translation: HumansAnimalsCells
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Interplay between the oxidoreductase PDIA6 and microRNA-322 controls the response to disrupted endoplasmic reticulum calcium homeostasis. Sci Signal. 2014 Jun 10; 7(329):ra54.
Groenendyk J, Peng Z, Dudek E, Fan X, Mizianty MJ, Dufey E, Urra H, Sepulveda D, Rojas-Rivera D, Lim Y, Kim DH, Baretta K, Srikanth S, Gwack Y, Ahnn J, Kaufman RJ, Lee SK, Hetz C, Kurgan L, Michalak M. PMID: 24917591.
View in: PubMed Mentions: 23 Fields: Translation: AnimalsCells
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Methods to measure cytoplasmic and mitochondrial Ca(2+) concentration using Ca(2+)-sensitive dyes. Methods Enzymol. 2014; 543:1-20.
Srikanth S, Kim KD, Gwack Y. PMID: 24924125.
View in: PubMed Mentions: 2 Fields: Translation: HumansAnimalsCells
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Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation. J Immunol. 2014 Jan 01; 192(1):110-22.
Kim KD, Srikanth S, Tan YV, Yee MK, Jew M, Damoiseaux R, Jung ME, Shimizu S, An DS, Ribalet B, Waschek JA, Gwack Y. PMID: 24307733.
View in: PubMed Mentions: 19 Fields: Translation: HumansAnimalsCells
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Orai1-NFAT signalling pathway triggered by T cell receptor stimulation. Mol Cells. 2013 Mar; 35(3):182-94.
Srikanth S, Gwack Y. PMID: 23483280.
View in: PubMed Mentions: 32 Fields: Translation: HumansAnimalsCells
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Regulation of CRAC channels by protein interactions and post-translational modification. Channels (Austin). 2013 Sep-Oct; 7(5):354-63.
Srikanth S, Ribalet B, Gwack Y. PMID: 23454861.
View in: PubMed Mentions: 3 Fields: Translation: HumansAnimalsCells
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Measurement of intracellular Ca2+ concentration in single cells using ratiometric calcium dyes. Methods Mol Biol. 2013; 963:3-14.
Srikanth S, Gwack Y. PMID: 23296601.
View in: PubMed Mentions: 5 Fields: Translation: HumansCells
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Molecular regulation of the pore component of CRAC channels, Orai1. Curr Top Membr. 2013; 71:181-207.
Srikanth S, Gwack Y. PMID: 23890116.
View in: PubMed Mentions: 6 Fields: Translation: HumansAnimalsCells
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Orai1, STIM1, and their associating partners. J Physiol. 2012 Sep 01; 590(17):4169-77.
Srikanth S, Gwack Y. PMID: 22586216.
View in: PubMed Mentions: 24 Fields: Translation: HumansAnimalsCells
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Junctate is a Ca2+-sensing structural component of Orai1 and stromal interaction molecule 1 (STIM1). Proc Natl Acad Sci U S A. 2012 May 29; 109(22):8682-7.
Srikanth S, Jew M, Kim KD, Yee MK, Abramson J, Gwack Y. PMID: 22586105.
View in: PubMed Mentions: 42 Fields: Translation: HumansCells
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ORAI1 deficiency impairs activated T cell death and enhances T cell survival. J Immunol. 2011 Oct 01; 187(7):3620-30.
Kim KD, Srikanth S, Yee MK, Mock DC, Lawson GW, Gwack Y. PMID: 21873530.
View in: PubMed Mentions: 30 Fields: Translation: HumansAnimalsCells
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The third transmembrane segment of orai1 protein modulates Ca2+ release-activated Ca2+ (CRAC) channel gating and permeation properties. J Biol Chem. 2011 Oct 07; 286(40):35318-28.
Srikanth S, Yee MK, Gwack Y, Ribalet B. PMID: 21865174.
View in: PubMed Mentions: 20 Fields: Translation: HumansAnimalsCells
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Protein kinase D orchestrates the activation of DRAK2 in response to TCR-induced Ca2+ influx and mitochondrial reactive oxygen generation. J Immunol. 2011 Jan 15; 186(2):940-50.
Newton RH, Leverrier S, Srikanth S, Gwack Y, Cahalan MD, Walsh CM. PMID: 21148796.
View in: PubMed Mentions: 6 Fields: Translation: HumansAnimalsCells
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A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells. Nat Cell Biol. 2010 May; 12(5):436-46.
Srikanth S, Jung HJ, Kim KD, Souda P, Whitelegge J, Gwack Y. PMID: 20418871.
View in: PubMed Mentions: 84 Fields: Translation: HumansCells
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The intracellular loop of Orai1 plays a central role in fast inactivation of Ca2+ release-activated Ca2+ channels. J Biol Chem. 2010 Feb 12; 285(7):5066-75.
Srikanth S, Jung HJ, Ribalet B, Gwack Y. PMID: 20007711.
View in: PubMed Mentions: 34 Fields: Translation: HumansAnimalsCells
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Hair loss and defective T- and B-cell function in mice lacking ORAI1. Mol Cell Biol. 2008 Sep; 28(17):5209-22.
Gwack Y, Srikanth S, Oh-Hora M, Hogan PG, Lamperti ED, Yamashita M, Gelinas C, Neems DS, Sasaki Y, Feske S, Prakriya M, Rajewsky K, Rao A. PMID: 18591248.
View in: PubMed Mentions: 135 Fields: Translation: AnimalsCells
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Dynamic movement of the calcium sensor STIM1 and the calcium channel Orai1 in activated T-cells: puncta and distal caps. Mol Biol Cell. 2008 Jul; 19(7):2802-17.
Barr VA, Bernot KM, Srikanth S, Gwack Y, Balagopalan L, Regan CK, Helman DJ, Sommers CL, Oh-Hora M, Rao A, Samelson LE. PMID: 18448669.
View in: PubMed Mentions: 63 Fields: Translation: HumansCells
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Signalling to transcription: store-operated Ca2+ entry and NFAT activation in lymphocytes. Cell Calcium. 2007 Aug; 42(2):145-56.
Gwack Y, Feske S, Srikanth S, Hogan PG, Rao A. PMID: 17572487.
View in: PubMed Mentions: 118 Fields: Translation: HumansAnimalsCells
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Biochemical and functional characterization of Orai proteins. J Biol Chem. 2007 Jun 01; 282(22):16232-43.
Gwack Y, Srikanth S, Feske S, Cruz-Guilloty F, Oh-hora M, Neems DS, Hogan PG, Rao A. PMID: 17293345.
View in: PubMed Mentions: 170 Fields: Translation: HumansAnimalsCells
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Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated calcium influx. Evidence for similarities in store-operated and calcium release-activated calcium channel components. J Biol Chem. 2007 Mar 23; 282(12):9105-16.
Ong HL, Cheng KT, Liu X, Bandyopadhyay BC, Paria BC, Soboloff J, Pani B, Gwack Y, Srikanth S, Singh BB, Gill DL, Gill D, Ambudkar IS. PMID: 17224452.
View in: PubMed Mentions: 148 Fields: Translation: HumansAnimalsCells
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Orai1 is an essential pore subunit of the CRAC channel. Nature. 2006 Sep 14; 443(7108):230-3.
Prakriya M, Feske S, Gwack Y, Srikanth S, Rao A, Hogan PG. PMID: 16921383.
View in: PubMed Mentions: 511 Fields: Translation: HumansCells
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A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature. 2006 May 11; 441(7090):179-85.
Feske S, Gwack Y, Prakriya M, Srikanth S, Puppel SH, Tanasa B, Hogan PG, Lewis RS, Daly M, Rao A. PMID: 16582901.
View in: PubMed Mentions: 836 Fields: Translation: HumansAnimalsCells
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A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT. Nature. 2006 Jun 01; 441(7093):646-50.
Gwack Y, Sharma S, Nardone J, Tanasa B, Iuga A, Srikanth S, Okamura H, Bolton D, Feske S, Hogan PG, Rao A. PMID: 16511445.
View in: PubMed Mentions: 144 Fields: Translation: AnimalsCells
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Year | Publications |
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2006 | 3 | 2007 | 3 | 2008 | 2 | 2009 | 1 | 2010 | 2 | 2011 | 2 | 2012 | 2 | 2013 | 5 | 2014 | 3 | 2015 | 1 | 2016 | 5 | 2017 | 3 | 2018 | 2 | 2019 | 4 | 2020 | 1 |
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
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