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Gwack Yousang

Title(s)Associate Professor, Physiology
Phone310-794-2003
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    Collapse Research 
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    Role of Orai1 trafficking in local effector T cell responses
    NIH/NIAID R56AI146615Aug 1, 2019 - Jul 31, 2020
    Role: Principal Investigator
    Development of an animal model of severe neutrophilic asthma
    NIH/NIAID R03AI147063Jul 1, 2019 - Jun 30, 2021
    Role: Principal Investigator
    Role of histone demethylase Kdm3C in age-associated oral and systemic inflammation
    NIH/NIDCR R21DE028269Sep 4, 2018 - Aug 31, 2020
    Role: Co-Principal Investigator
    The function of CRAC channels in airway inflammation
    NIH/NIAID R21AI109059Jan 1, 2016 - Dec 31, 2017
    Role: Principal Investigator
    A new class of immunomodulator, CRAC channel blockers
    NIH/NIAID R21AI101569Jul 1, 2012 - Jun 30, 2014
    Role: Principal Investigator
    Suppression of Immune Functions by a Peptide Blocking Function of CRAC Channels
    NIH/NIAID R21AI088393May 15, 2010 - Apr 30, 2013
    Role: Principal Investigator
    Novel lymphocyte-specific Rab GTPase in T cell differentiation
    NIH/NIAID R01AI083432Jul 1, 2009 - Oct 31, 2020
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Lee JY, Mehrazarin S, Alshaikh A, Kim S, Chen W, Lux R, Gwack Y, Kim RH, Kang MK. Histone Lys demethylase KDM3C demonstrates anti-inflammatory effects by suppressing NF-?B signaling and osteoclastogenesis. FASEB J. 2019 Sep; 33(9):10515-10527. PMID: 31251083.
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    2. Woo JS, Srikanth S, Kim KD, Elsaesser H, Lu J, Pellegrini M, Brooks DG, Sun Z, Gwack Y. Correction: CRACR2A-Mediated TCR Signaling Promotes Local Effector Th1 and Th17 Responses. J Immunol. 2019 Jul 01; 203(1):293. PMID: 31127031.
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    3. Rice L, Stockdale C, Berry I, O'Riordan S, Pysden K, Anwar R, Rushambuza R, Blyth M, Srikanth S, Gwack Y, El-Sherbiny YM, Carter C, Savic S. A Report of Novel STIM1 Deficiency and 6-Year Follow-Up of Two Previous Cases Associated with Mild Immunological Phenotype. J Clin Immunol. 2019 Apr; 39(3):249-256. PMID: 30949876.
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    4. Srikanth S, Woo JS, Wu B, El-Sherbiny YM, Leung J, Chupradit K, Rice L, Seo GJ, Calmettes G, Ramakrishna C, Cantin E, An DS, Sun R, Wu TT, Jung JU, Savic S, Gwack Y. The Ca2+ sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum. Nat Immunol. 2019 02; 20(2):152-162. PMID: 30643259.
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    5. He Z, Zhang J, Du Q, Xu J, Gwack Y, Sun Z. SRC3 Is a Cofactor for ROR?t in Th17 Differentiation but Not Thymocyte Development. J Immunol. 2019 02 01; 202(3):760-769. PMID: 30567733.
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    6. Woo JS, Srikanth S, Kim KD, Elsaesser H, Lu J, Pellegrini M, Brooks DG, Sun Z, Gwack Y. CRACR2A-Mediated TCR Signaling Promotes Local Effector Th1 and Th17 Responses. J Immunol. 2018 08 15; 201(4):1174-1185. PMID: 29987160.
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    7. Choi H, Srikanth S, Atti E, Pirih FQ, Nervina JM, Gwack Y, Tetradis S. Deletion of Orai1 leads to bone loss aggravated with aging and impairs function of osteoblast lineage cells. Bone Rep. 2018 Jun; 8:147-155. PMID: 29955633.
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    8. Sen S, Wang F, Zhang J, He Z, Ma J, Gwack Y, Xu J, Sun Z. SRC1 promotes Th17 differentiation by overriding Foxp3 suppression to stimulate ROR?t activity in a PKC-?-dependent manner. Proc Natl Acad Sci U S A. 2018 01 16; 115(3):E458-E467. PMID: 29282318.
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    9. He Z, Wang F, Zhang J, Sen S, Pang Q, Luo S, Gwack Y, Sun Z. Regulation of Th17 Differentiation by IKKa-Dependent and -Independent Phosphorylation of ROR?t. J Immunol. 2017 08 01; 199(3):955-964. PMID: 28667162.
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    10. Choi D, Park E, Jung E, Seong YJ, Yoo J, Lee E, Hong M, Lee S, Ishida H, Burford J, Peti-Peterdi J, Adams RH, Srikanth S, Gwack Y, Chen CS, Vogel HJ, Koh CJ, Wong AK, Hong YK. Laminar flow downregulates Notch activity to promote lymphatic sprouting. J Clin Invest. 2017 Apr 03; 127(4):1225-1240. PMID: 28263185.
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    11. Choi D, Park E, Jung E, Seong YJ, Hong M, Lee S, Burford J, Gyarmati G, Peti-Peterdi J, Srikanth S, Gwack Y, Koh CJ, Boriushkin E, Hamik A, Wong AK, Hong YK. ORAI1 Activates Proliferation of Lymphatic Endothelial Cells in Response to Laminar Flow Through Krüppel-Like Factors 2 and 4. Circ Res. 2017 Apr 28; 120(9):1426-1439. PMID: 28167653.
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    12. Srikanth S, Woo JS, Sun Z, Gwack Y. Immunological Disorders: Regulation of Ca2+ Signaling in T Lymphocytes. Adv Exp Med Biol. 2017; 993:397-424. PMID: 28900926.
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    13. He Z, Wang F, Ma J, Sen S, Zhang J, Gwack Y, Zhou Y, Sun Z. Ubiquitination of ROR?t at Lysine 446 Limits Th17 Differentiation by Controlling Coactivator Recruitment. J Immunol. 2016 08 15; 197(4):1148-58. PMID: 27430721.
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    14. Lee SH, Rigas NK, Lee CR, Bang A, Srikanth S, Gwack Y, Kang MK, Kim RH, Park NH, Shin KH. Orai1 promotes tumor progression by enhancing cancer stemness via NFAT signaling in oral/oropharyngeal squamous cell carcinoma. Oncotarget. 2016 Jul 12; 7(28):43239-43255. PMID: 27259269.
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    15. Srikanth S, Woo JS, Gwack Y. A large Rab GTPase family in a small GTPase world. Small GTPases. 2017 01 02; 8(1):43-48. PMID: 27221160.
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    16. Lee SH, Park Y, Song M, Srikanth S, Kim S, Kang MK, Gwack Y, Park NH, Kim RH, Shin KH. Orai1 mediates osteogenic differentiation via BMP signaling pathway in bone marrow mesenchymal stem cells. Biochem Biophys Res Commun. 2016 05 13; 473(4):1309-1314. PMID: 27086849.
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    17. Srikanth S, Kim KD, Gao Y, Woo JS, Ghosh S, Calmettes G, Paz A, Abramson J, Jiang M, Gwack Y. A large Rab GTPase encoded by CRACR2A is a component of subsynaptic vesicles that transmit T cell activation signals. Sci Signal. 2016 Mar 22; 9(420):ra31. PMID: 27016526.
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    18. Woo JS, Srikanth S, Nishi M, Ping P, Takeshima H, Gwack Y. Junctophilin-4, a component of the endoplasmic reticulum-plasma membrane junctions, regulates Ca2+ dynamics in T cells. Proc Natl Acad Sci U S A. 2016 Mar 08; 113(10):2762-7. PMID: 26929330.
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    19. Nurbaeva MK, Eckstein M, Concepcion AR, Smith CE, Srikanth S, Paine ML, Gwack Y, Hubbard MJ, Feske S, Lacruz RS. Dental enamel cells express functional SOCE channels. Sci Rep. 2015 Oct 30; 5:15803. PMID: 26515404.
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    20. Sohn S, Park Y, Srikanth S, Arai A, Song M, Yu B, Shin KH, Kang MK, Wang C, Gwack Y, Park NH, Kim RH. The Role of ORAI1 in the Odontogenic Differentiation of Human Dental Pulp Stem Cells. J Dent Res. 2015 Nov; 94(11):1560-7. PMID: 26403672.
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    21. Bertin S, Aoki-Nonaka Y, de Jong PR, Nohara LL, Xu H, Stanwood SR, Srikanth S, Lee J, To K, Abramson L, Yu T, Han T, Touma R, Li X, González-Navajas JM, Herdman S, Corr M, Fu G, Dong H, Gwack Y, Franco A, Jefferies WA, Raz E. The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4? T cells. Nat Immunol. 2014 Nov; 15(11):1055-1063. PMID: 25282159.
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    22. Groenendyk J, Peng Z, Dudek E, Fan X, Mizianty MJ, Dufey E, Urra H, Sepulveda D, Rojas-Rivera D, Lim Y, Kim DH, Baretta K, Srikanth S, Gwack Y, Ahnn J, Kaufman RJ, Lee SK, Hetz C, Kurgan L, Michalak M. Interplay between the oxidoreductase PDIA6 and microRNA-322 controls the response to disrupted endoplasmic reticulum calcium homeostasis. Sci Signal. 2014 Jun 10; 7(329):ra54. PMID: 24917591.
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    23. Srikanth S, Kim KD, Gwack Y. Methods to measure cytoplasmic and mitochondrial Ca(2+) concentration using Ca(2+)-sensitive dyes. Methods Enzymol. 2014; 543:1-20. PMID: 24924125.
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    24. Kim KD, Srikanth S, Tan YV, Yee MK, Jew M, Damoiseaux R, Jung ME, Shimizu S, An DS, Ribalet B, Waschek JA, Gwack Y. Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation. J Immunol. 2014 Jan 01; 192(1):110-22. PMID: 24307733.
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    25. Srikanth S, Gwack Y. Orai1-NFAT signalling pathway triggered by T cell receptor stimulation. Mol Cells. 2013 Mar; 35(3):182-94. PMID: 23483280.
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    26. Srikanth S, Ribalet B, Gwack Y. Regulation of CRAC channels by protein interactions and post-translational modification. Channels (Austin). 2013 Sep-Oct; 7(5):354-63. PMID: 23454861.
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    27. Srikanth S, Gwack Y. Molecular regulation of the pore component of CRAC channels, Orai1. Curr Top Membr. 2013; 71:181-207. PMID: 23890116.
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    28. Srikanth S, Gwack Y. Measurement of intracellular Ca2+ concentration in single cells using ratiometric calcium dyes. Methods Mol Biol. 2013; 963:3-14. PMID: 23296601.
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    29. Srikanth S, Jew M, Kim KD, Yee MK, Abramson J, Gwack Y. Junctate is a Ca2+-sensing structural component of Orai1 and stromal interaction molecule 1 (STIM1). Proc Natl Acad Sci U S A. 2012 May 29; 109(22):8682-7. PMID: 22586105.
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    30. Srikanth S, Gwack Y. Orai1, STIM1, and their associating partners. J Physiol. 2012 Sep 01; 590(17):4169-77. PMID: 22586216.
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    31. Kim KD, Srikanth S, Yee MK, Mock DC, Lawson GW, Gwack Y. ORAI1 deficiency impairs activated T cell death and enhances T cell survival. J Immunol. 2011 Oct 01; 187(7):3620-30. PMID: 21873530.
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    32. Srikanth S, Yee MK, Gwack Y, Ribalet B. The third transmembrane segment of orai1 protein modulates Ca2+ release-activated Ca2+ (CRAC) channel gating and permeation properties. J Biol Chem. 2011 Oct 07; 286(40):35318-28. PMID: 21865174.
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    33. Newton RH, Leverrier S, Srikanth S, Gwack Y, Cahalan MD, Walsh CM. Protein kinase D orchestrates the activation of DRAK2 in response to TCR-induced Ca2+ influx and mitochondrial reactive oxygen generation. J Immunol. 2011 Jan 15; 186(2):940-50. PMID: 21148796.
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    34. Srikanth S, Jung HJ, Kim KD, Souda P, Whitelegge J, Gwack Y. A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells. Nat Cell Biol. 2010 May; 12(5):436-46. PMID: 20418871.
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    35. Srikanth S, Jung HJ, Ribalet B, Gwack Y. The intracellular loop of Orai1 plays a central role in fast inactivation of Ca2+ release-activated Ca2+ channels. J Biol Chem. 2010 Feb 12; 285(7):5066-75. PMID: 20007711.
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    36. E X, Hwang S, Oh S, Lee JS, Jeong JH, Gwack Y, Kowalik TF, Sun R, Jung JU, Liang C. Viral Bcl-2-mediated evasion of autophagy aids chronic infection of gammaherpesvirus 68. PLoS Pathog. 2009 Oct; 5(10):e1000609. PMID: 19816569.
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    37. Gwack Y, Srikanth S, Oh-Hora M, Hogan PG, Lamperti ED, Yamashita M, Gelinas C, Neems DS, Sasaki Y, Feske S, Prakriya M, Rajewsky K, Rao A. Hair loss and defective T- and B-cell function in mice lacking ORAI1. Mol Cell Biol. 2008 Sep; 28(17):5209-22. PMID: 18591248.
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    38. Barr VA, Bernot KM, Srikanth S, Gwack Y, Balagopalan L, Regan CK, Helman DJ, Sommers CL, Oh-Hora M, Rao A, Samelson LE. Dynamic movement of the calcium sensor STIM1 and the calcium channel Orai1 in activated T-cells: puncta and distal caps. Mol Biol Cell. 2008 Jul; 19(7):2802-17. PMID: 18448669.
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    39. Gwack Y, Feske S, Srikanth S, Hogan PG, Rao A. Signalling to transcription: store-operated Ca2+ entry and NFAT activation in lymphocytes. Cell Calcium. 2007 Aug; 42(2):145-56. PMID: 17572487.
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    40. Gwack Y, Srikanth S, Feske S, Cruz-Guilloty F, Oh-hora M, Neems DS, Hogan PG, Rao A. Biochemical and functional characterization of Orai proteins. J Biol Chem. 2007 Jun 01; 282(22):16232-43. PMID: 17293345.
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    41. Ong HL, Cheng KT, Liu X, Bandyopadhyay BC, Paria BC, Soboloff J, Pani B, Gwack Y, Srikanth S, Singh BB, Gill DL, Gill D, Ambudkar IS. Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated calcium influx. Evidence for similarities in store-operated and calcium release-activated calcium channel components. J Biol Chem. 2007 Mar 23; 282(12):9105-16. PMID: 17224452.
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    42. Prakriya M, Feske S, Gwack Y, Srikanth S, Rao A, Hogan PG. Orai1 is an essential pore subunit of the CRAC channel. Nature. 2006 Sep 14; 443(7108):230-3. PMID: 16921383.
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    43. Feske S, Gwack Y, Prakriya M, Srikanth S, Puppel SH, Tanasa B, Hogan PG, Lewis RS, Daly M, Rao A. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature. 2006 May 11; 441(7090):179-85. PMID: 16582901.
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    44. Gwack Y, Sharma S, Nardone J, Tanasa B, Iuga A, Srikanth S, Okamura H, Bolton D, Feske S, Hogan PG, Rao A. A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT. Nature. 2006 Jun 01; 441(7093):646-50. PMID: 16511445.
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    45. Chang H, Gwack Y, Kingston D, Souvlis J, Liang X, Means RE, Cesarman E, Hutt-Fletcher L, Jung JU. Activation of CD21 and CD23 gene expression by Kaposi's sarcoma-associated herpesvirus RTA. J Virol. 2005 Apr; 79(8):4651-63. PMID: 15795251.
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    46. Lee SH, Chung YH, Cho NH, Gwack Y, Feng P, Jung JU. Modulation of T-cell receptor signal transduction by herpesvirus signaling adaptor protein. Mol Cell Biol. 2004 Jun; 24(12):5369-82. PMID: 15169900.
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    47. Gwack Y, Nakamura H, Lee SH, Souvlis J, Yustein JT, Gygi S, Kung HJ, Jung JU. Poly(ADP-ribose) polymerase 1 and Ste20-like kinase hKFC act as transcriptional repressors for gamma-2 herpesvirus lytic replication. Mol Cell Biol. 2003 Nov; 23(22):8282-94. PMID: 14585985.
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    48. Nakamura H, Lu M, Gwack Y, Souvlis J, Zeichner SL, Jung JU. Global changes in Kaposi's sarcoma-associated virus gene expression patterns following expression of a tetracycline-inducible Rta transactivator. J Virol. 2003 Apr; 77(7):4205-20. PMID: 12634378.
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    49. Gwack Y, Baek HJ, Nakamura H, Lee SH, Meisterernst M, Roeder RG, Jung JU. Principal role of TRAP/mediator and SWI/SNF complexes in Kaposi's sarcoma-associated herpesvirus RTA-mediated lytic reactivation. Mol Cell Biol. 2003 Mar; 23(6):2055-67. PMID: 12612078.
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    50. Hwang S, Lee D, Gwack Y, Min H, Choe J. Kaposi's sarcoma-associated herpesvirus K8 protein interacts with hSNF5. J Gen Virol. 2003 Mar; 84(Pt 3):665-76. PMID: 12604819.
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    51. Byun H, Gwack Y, Hwang S, Choe J. Kaposi's sarcoma-associated herpesvirus open reading frame (ORF) 50 transactivates K8 and ORF57 promoters via heterogeneous response elements. Mol Cells. 2002 Oct 31; 14(2):185-91. PMID: 12442889.
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    52. Lim C, Sohn H, Lee D, Gwack Y, Choe J. Functional dissection of latency-associated nuclear antigen 1 of Kaposi's sarcoma-associated herpesvirus involved in latent DNA replication and transcription of terminal repeats of the viral genome. J Virol. 2002 Oct; 76(20):10320-31. PMID: 12239308.
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    53. Gwack Y, Hwang S, Lim C, Won YS, Lee CH, Choe J. Kaposi's Sarcoma-associated herpesvirus open reading frame 50 stimulates the transcriptional activity of STAT3. J Biol Chem. 2002 Feb 22; 277(8):6438-42. PMID: 11741976.
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    54. Hwang S, Gwack Y, Byun H, Lim C, Choe J. The Kaposi's sarcoma-associated herpesvirus K8 protein interacts with CREB-binding protein (CBP) and represses CBP-mediated transcription. J Virol. 2001 Oct; 75(19):9509-16. PMID: 11533213.
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    55. Gwack Y, Hwang S, Byun H, Lim C, Kim JW, Choi EJ, Choe J. Kaposi's sarcoma-associated herpesvirus open reading frame 50 represses p53-induced transcriptional activity and apoptosis. J Virol. 2001 Jul; 75(13):6245-8. PMID: 11390631.
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    56. Lim C, Gwack Y, Hwang S, Kim S, Choe J. The transcriptional activity of cAMP response element-binding protein-binding protein is modulated by the latency associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus. J Biol Chem. 2001 Aug 17; 276(33):31016-22. PMID: 11425857.
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    57. Gwack Y, Byun H, Hwang S, Lim C, Choe J. CREB-binding protein and histone deacetylase regulate the transcriptional activity of Kaposi's sarcoma-associated herpesvirus open reading frame 50. J Virol. 2001 Feb; 75(4):1909-17. PMID: 11160690.
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    58. Park J, Seo T, Hwang S, Lee D, Gwack Y, Choe J. The K-bZIP protein from Kaposi's sarcoma-associated herpesvirus interacts with p53 and represses its transcriptional activity. J Virol. 2000 Dec; 74(24):11977-82. PMID: 11090200.
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    59. Lim C, Sohn H, Gwack Y, Choe J. Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) binds ATF4/CREB2 and inhibits its transcriptional activation activity. J Gen Virol. 2000 Nov; 81(Pt 11):2645-52. PMID: 11038375.
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    60. Gwack Y, Yoo H, Song I, Choe J, Han JH. RNA-Stimulated ATPase and RNA helicase activities and RNA binding domain of hepatitis G virus nonstructural protein 3. J Virol. 1999 Apr; 73(4):2909-15. PMID: 10074139.
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    61. Kim DW, Kim J, Gwack Y, Han JH, Choe J. Mutational analysis of the hepatitis C virus RNA helicase. J Virol. 1997 Dec; 71(12):9400-9. PMID: 9371600.
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    62. Gwack Y, Kim DW, Han JH, Choe J. DNA helicase activity of the hepatitis C virus nonstructural protein 3. Eur J Biochem. 1997 Nov 15; 250(1):47-54. PMID: 9431989.
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    63. Kim DW, Gwack Y, Han JH, Choe J. Towards defining a minimal functional domain for NTPase and RNA helicase activities of the hepatitis C virus NS3 protein. Virus Res. 1997 May; 49(1):17-25. PMID: 9178493.
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    64. Gwack Y, Kim DW, Han JH, Choe J. Characterization of RNA binding activity and RNA helicase activity of the hepatitis C virus NS3 protein. Biochem Biophys Res Commun. 1996 Aug 14; 225(2):654-9. PMID: 8753814.
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    65. Kim DW, Gwack Y, Han JH, Choe J. C-terminal domain of the hepatitis C virus NS3 protein contains an RNA helicase activity. Biochem Biophys Res Commun. 1995 Oct 04; 215(1):160-6. PMID: 7575585.
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