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Yousang Gwack

Title(s)Professor, Physiology
SchoolMedicine
Address760 Westwood Plaza 53-231
Los Angeles CA 90024
Phone3107942003
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    Distinctive role of ORAI3 channels in the effector T cell response
    NIH/NIAID R21AI149236Jun 1, 2020 - May 31, 2022
    Role: Principal Investigator
    Mechanism underlying regulation of Ca2+ signaling in local effector T cells
    NIH/NIAID R01AI146615Mar 5, 2020 - Feb 28, 2025
    Role: Principal Investigator
    Role of Orai1 trafficking in local effector T cell responses
    NIH/NIAID R56AI146615Aug 1, 2019 - Jul 31, 2020
    Role: Principal Investigator
    Development of an animal model of severe neutrophilic asthma
    NIH/NIAID R03AI147063Jul 1, 2019 - Jun 30, 2021
    Role: Principal Investigator
    Role of histone demethylase Kdm3C in age-associated oral and systemic inflammation
    NIH/NIDCR R21DE028269Sep 4, 2018 - Aug 31, 2020
    Role: Co-Principal Investigator
    The function of CRAC channels in airway inflammation
    NIH/NIAID R21AI109059Jan 1, 2016 - Dec 31, 2017
    Role: Principal Investigator
    A new class of immunomodulator, CRAC channel blockers
    NIH/NIAID R21AI101569Jul 1, 2012 - Jun 30, 2014
    Role: Principal Investigator
    Suppression of Immune Functions by a Peptide Blocking Function of CRAC Channels
    NIH/NIAID R21AI088393May 15, 2010 - Apr 30, 2013
    Role: Principal Investigator
    Novel lymphocyte-specific Rab GTPase in T cell differentiation
    NIH/NIAID R01AI083432Jul 1, 2009 - Oct 31, 2020
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The short isoform of extended synaptotagmin-2 controls Ca2+ dynamics in T cells via interaction with STIM1. Sci Rep. 2020 09 02; 10(1):14433. Woo JS, Sun Z, Srikanth S, Gwack Y. PMID: 32879390.
      View in: PubMed   Mentions:    Fields:    
    2. Histone Lys demethylase KDM3C demonstrates anti-inflammatory effects by suppressing NF-κB signaling and osteoclastogenesis. FASEB J. 2019 09; 33(9):10515-10527. Lee JY, Mehrazarin S, Alshaikh A, Kim S, Chen W, Lux R, Gwack Y, Kim RH, Kang MK. PMID: 31251083.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    3. Correction: CRACR2A-Mediated TCR Signaling Promotes Local Effector Th1 and Th17 Responses. J Immunol. 2019 Jul 01; 203(1):293. Woo JS, Srikanth S, Kim KD, Elsaesser H, Lu J, Pellegrini M, Brooks DG, Sun Z, Gwack Y. PMID: 31127031.
      View in: PubMed   Mentions:    Fields:    
    4. A Report of Novel STIM1 Deficiency and 6-Year Follow-Up of Two Previous Cases Associated with Mild Immunological Phenotype. J Clin Immunol. 2019 04; 39(3):249-256. Rice L, Stockdale C, Berry I, O'Riordan S, Pysden K, Anwar R, Rushambuza R, Blyth M, Srikanth S, Gwack Y, El-Sherbiny YM, Carter C, Savic S. PMID: 30949876.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    5. The Ca2+ sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum. Nat Immunol. 2019 02; 20(2):152-162. Srikanth S, Woo JS, Wu B, El-Sherbiny YM, Leung J, Chupradit K, Rice L, Seo GJ, Calmettes G, Ramakrishna C, Cantin E, An DS, Sun R, Wu TT, Jung JU, Savic S, Gwack Y. PMID: 30643259.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    6. CRACR2A-Mediated TCR Signaling Promotes Local Effector Th1 and Th17 Responses. J Immunol. 2018 08 15; 201(4):1174-1185. Woo JS, Srikanth S, Kim KD, Elsaesser H, Lu J, Pellegrini M, Brooks DG, Sun Z, Gwack Y. PMID: 29987160.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    7. Deletion of Orai1 leads to bone loss aggravated with aging and impairs function of osteoblast lineage cells. Bone Rep. 2018 Jun; 8:147-155. Choi H, Srikanth S, Atti E, Pirih FQ, Nervina JM, Gwack Y, Tetradis S. PMID: 29955633.
      View in: PubMed   Mentions:
    8. Laminar flow downregulates Notch activity to promote lymphatic sprouting. J Clin Invest. 2017 Apr 03; 127(4):1225-1240. Choi D, Park E, Jung E, Seong YJ, Yoo J, Lee E, Hong M, Lee S, Ishida H, Burford J, Peti-Peterdi J, Adams RH, Srikanth S, Gwack Y, Chen CS, Vogel HJ, Koh CJ, Wong AK, Hong YK. PMID: 28263185.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    9. ORAI1 Activates Proliferation of Lymphatic Endothelial Cells in Response to Laminar Flow Through Krüppel-Like Factors 2 and 4. Circ Res. 2017 Apr 28; 120(9):1426-1439. Choi D, Park E, Jung E, Seong YJ, Hong M, Lee S, Burford J, Gyarmati G, Peti-Peterdi J, Srikanth S, Gwack Y, Koh CJ, Boriushkin E, Hamik A, Wong AK, Hong YK. PMID: 28167653.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    10. Immunological Disorders: Regulation of Ca2+ Signaling in T Lymphocytes. Adv Exp Med Biol. 2017; 993:397-424. Srikanth S, Woo JS, Sun Z, Gwack Y. PMID: 28900926.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    11. Orai1 promotes tumor progression by enhancing cancer stemness via NFAT signaling in oral/oropharyngeal squamous cell carcinoma. Oncotarget. 2016 Jul 12; 7(28):43239-43255. Lee SH, Rigas NK, Lee CR, Bang A, Srikanth S, Gwack Y, Kang MK, Kim RH, Park NH, Shin KH. PMID: 27259269.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    12. A large Rab GTPase family in a small GTPase world. Small GTPases. 2017 01 02; 8(1):43-48. Srikanth S, Woo JS, Gwack Y. PMID: 27221160.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    13. Orai1 mediates osteogenic differentiation via BMP signaling pathway in bone marrow mesenchymal stem cells. Biochem Biophys Res Commun. 2016 05 13; 473(4):1309-1314. Lee SH, Park Y, Song M, Srikanth S, Kim S, Kang MK, Gwack Y, Park NH, Kim RH, Shin KH. PMID: 27086849.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    14. A large Rab GTPase encoded by CRACR2A is a component of subsynaptic vesicles that transmit T cell activation signals. Sci Signal. 2016 Mar 22; 9(420):ra31. Srikanth S, Kim KD, Gao Y, Woo JS, Ghosh S, Calmettes G, Paz A, Abramson J, Jiang M, Gwack Y. PMID: 27016526.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    15. Junctophilin-4, a component of the endoplasmic reticulum-plasma membrane junctions, regulates Ca2+ dynamics in T cells. Proc Natl Acad Sci U S A. 2016 Mar 08; 113(10):2762-7. Woo JS, Srikanth S, Nishi M, Ping P, Takeshima H, Gwack Y. PMID: 26929330.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    16. Dental enamel cells express functional SOCE channels. Sci Rep. 2015 Oct 30; 5:15803. Nurbaeva MK, Eckstein M, Concepcion AR, Smith CE, Srikanth S, Paine ML, Gwack Y, Hubbard MJ, Feske S, Lacruz RS. PMID: 26515404.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    17. The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4? T cells. Nat Immunol. 2014 Nov; 15(11):1055-1063. Bertin S, Aoki-Nonaka Y, de Jong PR, Nohara LL, Xu H, Stanwood SR, Srikanth S, Lee J, To K, Abramson L, Yu T, Han T, Touma R, Li X, González-Navajas JM, Herdman S, Corr M, Fu G, Dong H, Gwack Y, Franco A, Jefferies WA, Raz E. PMID: 25282159.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    18. Interplay between the oxidoreductase PDIA6 and microRNA-322 controls the response to disrupted endoplasmic reticulum calcium homeostasis. Sci Signal. 2014 Jun 10; 7(329):ra54. Groenendyk J, Peng Z, Dudek E, Fan X, Mizianty MJ, Dufey E, Urra H, Sepulveda D, Rojas-Rivera D, Lim Y, Kim DH, Baretta K, Srikanth S, Gwack Y, Ahnn J, Kaufman RJ, Lee SK, Hetz C, Kurgan L, Michalak M. PMID: 24917591.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    19. Methods to measure cytoplasmic and mitochondrial Ca(2+) concentration using Ca(2+)-sensitive dyes. Methods Enzymol. 2014; 543:1-20. Srikanth S, Kim KD, Gwack Y. PMID: 24924125.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    20. Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation. J Immunol. 2014 Jan 01; 192(1):110-22. Kim KD, Srikanth S, Tan YV, Yee MK, Jew M, Damoiseaux R, Jung ME, Shimizu S, An DS, Ribalet B, Waschek JA, Gwack Y. PMID: 24307733.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    21. Orai1-NFAT signalling pathway triggered by T cell receptor stimulation. Mol Cells. 2013 Mar; 35(3):182-94. Srikanth S, Gwack Y. PMID: 23483280.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    22. Regulation of CRAC channels by protein interactions and post-translational modification. Channels (Austin). 2013 Sep-Oct; 7(5):354-63. Srikanth S, Ribalet B, Gwack Y. PMID: 23454861.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    23. Measurement of intracellular Ca2+ concentration in single cells using ratiometric calcium dyes. Methods Mol Biol. 2013; 963:3-14. Srikanth S, Gwack Y. PMID: 23296601.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    24. Molecular regulation of the pore component of CRAC channels, Orai1. Curr Top Membr. 2013; 71:181-207. Srikanth S, Gwack Y. PMID: 23890116.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    25. Orai1, STIM1, and their associating partners. J Physiol. 2012 Sep 01; 590(17):4169-77. Srikanth S, Gwack Y. PMID: 22586216.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    26. Junctate is a Ca2+-sensing structural component of Orai1 and stromal interaction molecule 1 (STIM1). Proc Natl Acad Sci U S A. 2012 May 29; 109(22):8682-7. Srikanth S, Jew M, Kim KD, Yee MK, Abramson J, Gwack Y. PMID: 22586105.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    27. ORAI1 deficiency impairs activated T cell death and enhances T cell survival. J Immunol. 2011 Oct 01; 187(7):3620-30. Kim KD, Srikanth S, Yee MK, Mock DC, Lawson GW, Gwack Y. PMID: 21873530.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    28. The third transmembrane segment of orai1 protein modulates Ca2+ release-activated Ca2+ (CRAC) channel gating and permeation properties. J Biol Chem. 2011 Oct 07; 286(40):35318-28. Srikanth S, Yee MK, Gwack Y, Ribalet B. PMID: 21865174.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    29. Protein kinase D orchestrates the activation of DRAK2 in response to TCR-induced Ca2+ influx and mitochondrial reactive oxygen generation. J Immunol. 2011 Jan 15; 186(2):940-50. Newton RH, Leverrier S, Srikanth S, Gwack Y, Cahalan MD, Walsh CM. PMID: 21148796.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    30. A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells. Nat Cell Biol. 2010 May; 12(5):436-46. Srikanth S, Jung HJ, Kim KD, Souda P, Whitelegge J, Gwack Y. PMID: 20418871.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansCells
    31. The intracellular loop of Orai1 plays a central role in fast inactivation of Ca2+ release-activated Ca2+ channels. J Biol Chem. 2010 Feb 12; 285(7):5066-75. Srikanth S, Jung HJ, Ribalet B, Gwack Y. PMID: 20007711.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    32. Hair loss and defective T- and B-cell function in mice lacking ORAI1. Mol Cell Biol. 2008 Sep; 28(17):5209-22. Gwack Y, Srikanth S, Oh-Hora M, Hogan PG, Lamperti ED, Yamashita M, Gelinas C, Neems DS, Sasaki Y, Feske S, Prakriya M, Rajewsky K, Rao A. PMID: 18591248.
      View in: PubMed   Mentions: 135     Fields:    Translation:AnimalsCells
    33. Dynamic movement of the calcium sensor STIM1 and the calcium channel Orai1 in activated T-cells: puncta and distal caps. Mol Biol Cell. 2008 Jul; 19(7):2802-17. Barr VA, Bernot KM, Srikanth S, Gwack Y, Balagopalan L, Regan CK, Helman DJ, Sommers CL, Oh-Hora M, Rao A, Samelson LE. PMID: 18448669.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansCells
    34. Signalling to transcription: store-operated Ca2+ entry and NFAT activation in lymphocytes. Cell Calcium. 2007 Aug; 42(2):145-56. Gwack Y, Feske S, Srikanth S, Hogan PG, Rao A. PMID: 17572487.
      View in: PubMed   Mentions: 118     Fields:    Translation:HumansAnimalsCells
    35. Biochemical and functional characterization of Orai proteins. J Biol Chem. 2007 Jun 01; 282(22):16232-43. Gwack Y, Srikanth S, Feske S, Cruz-Guilloty F, Oh-hora M, Neems DS, Hogan PG, Rao A. PMID: 17293345.
      View in: PubMed   Mentions: 170     Fields:    Translation:HumansAnimalsCells
    36. Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated calcium influx. Evidence for similarities in store-operated and calcium release-activated calcium channel components. J Biol Chem. 2007 Mar 23; 282(12):9105-16. Ong HL, Cheng KT, Liu X, Bandyopadhyay BC, Paria BC, Soboloff J, Pani B, Gwack Y, Srikanth S, Singh BB, Gill DL, Gill D, Ambudkar IS. PMID: 17224452.
      View in: PubMed   Mentions: 148     Fields:    Translation:HumansAnimalsCells
    37. Orai1 is an essential pore subunit of the CRAC channel. Nature. 2006 Sep 14; 443(7108):230-3. Prakriya M, Feske S, Gwack Y, Srikanth S, Rao A, Hogan PG. PMID: 16921383.
      View in: PubMed   Mentions: 511     Fields:    Translation:HumansCells
    38. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature. 2006 May 11; 441(7090):179-85. Feske S, Gwack Y, Prakriya M, Srikanth S, Puppel SH, Tanasa B, Hogan PG, Lewis RS, Daly M, Rao A. PMID: 16582901.
      View in: PubMed   Mentions: 836     Fields:    Translation:HumansAnimalsCells
    39. A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT. Nature. 2006 Jun 01; 441(7093):646-50. Gwack Y, Sharma S, Nardone J, Tanasa B, Iuga A, Srikanth S, Okamura H, Bolton D, Feske S, Hogan PG, Rao A. PMID: 16511445.
      View in: PubMed   Mentions: 144     Fields:    Translation:AnimalsCells
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