Yousang Gwack

Title(s)Department Vice Chair, Physiology
SchoolMedicine
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    Title(s)Professor, Physiology


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    Distinctive role of ORAI3 channels in the effector T cell response
    NIH R21AI149236Jun 1, 2020 - May 31, 2022
    Role: Principal Investigator
    Mechanism underlying regulation of Ca2+ signaling in local effector T cells
    NIH R01AI146615Mar 5, 2020 - Feb 28, 2025
    Role: Principal Investigator
    Role of Orai1 trafficking in local effector T cell responses
    NIH R56AI146615Aug 1, 2019 - Mar 4, 2020
    Role: Principal Investigator
    Development of an animal model of severe neutrophilic asthma
    NIH R03AI147063Jul 1, 2019 - Jun 30, 2021
    Role: Principal Investigator
    Role of histone demethylase Kdm3C in age-associated oral and systemic inflammation
    NIH R21DE028269Sep 4, 2018 - Aug 31, 2021
    Role: Co-Principal Investigator
    The function of CRAC channels in airway inflammation
    NIH R21AI109059Jan 1, 2016 - Dec 31, 2017
    Role: Principal Investigator
    A new class of immunomodulator, CRAC channel blockers
    NIH R21AI101569Jul 1, 2012 - Jun 30, 2014
    Role: Principal Investigator
    Suppression of Immune Functions by a Peptide Blocking Function of CRAC Channels
    NIH R21AI088393May 15, 2010 - Apr 30, 2013
    Role: Principal Investigator
    Novel lymphocyte-specific Rab GTPase in T cell differentiation
    NIH R01AI083432Jul 1, 2009 - Oct 31, 2021
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Correction to: Neutrophil CRACR2A Promotes Neutrophil Recruitment in Sterile Inflammation and Ischemic Stroke. Circulation. 2025 Apr 22; 151(16):e961. Lee J, Balzraine B, Schweizer A, Kuzmanova V, Gwack Y, Razani B, Lee JM, Mosher DF, Cho J. PMID: 40258052.
      View in: PubMed   Mentions:    Fields:    
    2. Mitochondrial reactive oxygen species regulate acetyl-CoA flux between cytokine production and fatty acid synthesis in effector T cells. Cell Rep. 2025 Mar 25; 44(3):115430. Wu B, Woo JS, Hasiakos S, Pan C, Cokus S, Benincá C, Stiles L, Sun Z, Pellegrini M, Shirihai OS, Lusis AJ, Srikanth S, Gwack Y. PMID: 40088449; PMCID: PMC12007815.
      View in: PubMed   Mentions:    Fields:    
    3. Neutrophil CRACR2A Promotes Neutrophil Recruitment in Sterile Inflammation and Ischemic Stroke. Circulation. 2025 Mar 11; 151(10):696-715. Lee J, Balzraine B, Schweizer A, Kuzmanova V, Gwack Y, Razani B, Lee JM, Mosher DF, Cho J. PMID: 39601147; PMCID: PMC11893261.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    4. Distinct RORγt-dependent Th17 immune responses are required for autoimmune pathogenesis and protection against bacterial infection. Cell Rep. 2024 11 26; 43(11):114951. Zhong X, Wu H, Zhang W, Shi Y, Gwack Y, Xue HH, Sun Z. PMID: 39504243; PMCID: PMC11931457.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    5. Ncoa2 Promotes CD8+ T cell-Mediated Antitumor Immunity by Stimulating T-cell Activation via Upregulation of PGC-1α Critical for Mitochondrial Function. Cancer Immunol Res. 2023 10 04; 11(10):1414-1431. Zhong X, Wu H, Ouyang C, Zhang W, Shi Y, Wang YC, Ann DK, Gwack Y, Shang W, Sun Z. PMID: 37540802; PMCID: PMC10592187.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    6. Orai inhibition modulates pulmonary ILC2 metabolism and alleviates airway hyperreactivity in murine and humanized models. Nat Commun. 2023 09 26; 14(1):5989. Howard E, Hurrell BP, Helou DG, Shafiei-Jahani P, Hasiakos S, Painter J, Srikanth S, Gwack Y, Akbari O. PMID: 37752127; PMCID: PMC10522697.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    7. Orai3 Calcium Channel Contributes to Oral/Oropharyngeal Cancer Stemness through the Elevation of ID1 Expression. Cells. 2023 09 07; 12(18). Nguyen A, Sung Y, Lee SH, Martin CE, Srikanth S, Chen W, Kang MK, Kim RH, Park NH, Gwack Y, Kim Y, Shin KH. PMID: 37759448; PMCID: PMC10527097.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. SRC2 controls CD4+ T cell activation via stimulating c-Myc-mediated upregulation of amino acid transporter Slc7a5. Proc Natl Acad Sci U S A. 2023 05 02; 120(18):e2221352120. Zhang W, Cao X, Zhong X, Wu H, Shi Y, Feng M, Wang YC, Ann D, Gwack Y, Yuan YC, Shang W, Sun Z. PMID: 37094160; PMCID: PMC10160970.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    9. Decoupling the role of RORγt in the differentiation and effector function of TH17 cells. Sci Adv. 2022 Oct 21; 8(42):eadc9221. Zhong X, Wu H, Zhang W, Gwack Y, Shang W, Lee KO, Isakov N, He Z, Sun Z. PMID: 36269826; PMCID: PMC9586477.
      View in: PubMed   Mentions: 4     Fields:    
    10. Steroid nuclear receptor coactivator 2 controls immune tolerance by promoting induced Treg differentiation via up-regulating Nr4a2. Sci Adv. 2022 06 17; 8(24):eabn7662. Zhang W, Cao X, Zhong X, Wu H, Feng M, Gwack Y, Isakov N, Sun Z. PMID: 35704583; PMCID: PMC9200286.
      View in: PubMed   Mentions: 5     Fields:    
    11. Long-Term Ligature-Induced Periodontitis Exacerbates Development of Bisphosphonate-Related Osteonecrosis of the Jaw in Mice. J Bone Miner Res. 2022 07; 37(7):1400-1410. Williams DW, Ho K, Lenon A, Kim S, Kim T, Gwack Y, Kim RH. PMID: 35598324; PMCID: PMC9386631.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    12. Ca2+ Signaling Augmented by ORAI1 Trafficking Regulates the Pathogenic State of Effector T Cells. J Immunol. 2022 03 15; 208(6):1329-1340. Wu B, Woo JS, Sun Z, Srikanth S, Gwack Y. PMID: 35217583; PMCID: PMC8916982.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    13. Biallelic mutations in calcium release activated channel regulator 2A (CRACR2A) cause a primary immunodeficiency disorder. Elife. 2021 12 15; 10. Wu B, Rice L, Shrimpton J, Lawless D, Walker K, Carter C, McKeown L, Anwar R, Doody GM, Srikanth S, Gwack Y, Savic S. PMID: 34908525; PMCID: PMC8673834.
      View in: PubMed   Mentions: 9     Fields:    
    14. Insulin-activated store-operated Ca2+ entry via Orai1 induces podocyte actin remodeling and causes proteinuria. Nat Commun. 2021 11 11; 12(1):6537. Kim JH, Hwang KH, Dang BTN, Eom M, Kong ID, Gwack Y, Yu S, Gee HY, Birnbaumer L, Park KS, Cha SK. PMID: 34764278; PMCID: PMC8586150.
      View in: PubMed   Mentions: 14     Fields:    
    15. NKD2 mediates stimulation-dependent ORAI1 trafficking to augment Ca2+ entry in T cells. Cell Rep. 2021 08 24; 36(8):109603. Wu B, Woo JS, Vila P, Jew M, Leung J, Sun Z, Srikanth S, Gwack Y. PMID: 34433025; PMCID: PMC8435239.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    16. ORAI1 establishes resistance to SARS-CoV-2 infection by regulating tonic type I interferon signaling. bioRxiv. 2021 May 04. Wu B, Ramaiah A, Garcia G, Gwack Y, Arumugaswami V, Srikanth S. PMID: 33972946; PMCID: PMC8109209.
      View in: PubMed   Mentions:
    17. Blue light opens the ORAI1 LOC(K). Cell Calcium. 2021 05; 95:102371. Srikanth S, Gwack Y. PMID: 33626404.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    18. Calcium Signaling in T Cells and Chronic Inflammatory Disorders of the Oral Cavity. J Dent Res. 2021 07; 100(7):693-699. Hasiakos S, Gwack Y, Kang M, Nishimura I. PMID: 33541200; PMCID: PMC8221706.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    19. The short isoform of extended synaptotagmin-2 controls Ca2+ dynamics in T cells via interaction with STIM1. Sci Rep. 2020 09 02; 10(1):14433. Woo JS, Sun Z, Srikanth S, Gwack Y. PMID: 32879390; PMCID: PMC7468131.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    20. Histone Lys demethylase KDM3C demonstrates anti-inflammatory effects by suppressing NF-κB signaling and osteoclastogenesis. FASEB J. 2019 09; 33(9):10515-10527. Lee JY, Mehrazarin S, Alshaikh A, Kim S, Chen W, Lux R, Gwack Y, Kim RH, Kang MK. PMID: 31251083; PMCID: PMC6704463.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    21. Correction: CRACR2A-Mediated TCR Signaling Promotes Local Effector Th1 and Th17 Responses. J Immunol. 2019 Jul 01; 203(1):293. Woo JS, Srikanth S, Kim KD, Elsaesser H, Lu J, Pellegrini M, Brooks DG, Sun Z, Gwack Y. PMID: 31127031.
      View in: PubMed   Mentions:    Fields:    
    22. A Report of Novel STIM1 Deficiency and 6-Year Follow-Up of Two Previous Cases Associated with Mild Immunological Phenotype. J Clin Immunol. 2019 04; 39(3):249-256. Rice L, Stockdale C, Berry I, O'Riordan S, Pysden K, Anwar R, Rushambuza R, Blyth M, Srikanth S, Gwack Y, El-Sherbiny YM, Carter C, Savic S. PMID: 30949876.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    23. The Ca2+ sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum. Nat Immunol. 2019 02; 20(2):152-162. Srikanth S, Woo JS, Wu B, El-Sherbiny YM, Leung J, Chupradit K, Rice L, Seo GJ, Calmettes G, Ramakrishna C, Cantin E, An DS, Sun R, Wu TT, Jung JU, Savic S, Gwack Y. PMID: 30643259; PMCID: PMC6340781.
      View in: PubMed   Mentions: 158     Fields:    Translation:HumansAnimalsCells
    24. SRC3 Is a Cofactor for RORγt in Th17 Differentiation but Not Thymocyte Development. J Immunol. 2019 02 01; 202(3):760-769. He Z, Zhang J, Du Q, Xu J, Gwack Y, Sun Z. PMID: 30567733; PMCID: PMC6344289.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    25. CRACR2A-Mediated TCR Signaling Promotes Local Effector Th1 and Th17 Responses. J Immunol. 2018 08 15; 201(4):1174-1185. Woo JS, Srikanth S, Kim KD, Elsaesser H, Lu J, Pellegrini M, Brooks DG, Sun Z, Gwack Y. PMID: 29987160; PMCID: PMC6081249.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    26. Deletion of Orai1 leads to bone loss aggravated with aging and impairs function of osteoblast lineage cells. Bone Rep. 2018 Jun; 8:147-155. Choi H, Srikanth S, Atti E, Pirih FQ, Nervina JM, Gwack Y, Tetradis S. PMID: 29955633; PMCID: PMC6020256.
      View in: PubMed   Mentions: 9  
    27. SRC1 promotes Th17 differentiation by overriding Foxp3 suppression to stimulate RORγt activity in a PKC-θ-dependent manner. Proc Natl Acad Sci U S A. 2018 01 16; 115(3):E458-E467. Sen S, Wang F, Zhang J, He Z, Ma J, Gwack Y, Xu J, Sun Z. PMID: 29282318; PMCID: PMC5776998.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    28. Regulation of Th17 Differentiation by IKKα-Dependent and -Independent Phosphorylation of RORγt. J Immunol. 2017 08 01; 199(3):955-964. He Z, Wang F, Zhang J, Sen S, Pang Q, Luo S, Gwack Y, Sun Z. PMID: 28667162; PMCID: PMC5531059.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    29. Laminar flow downregulates Notch activity to promote lymphatic sprouting. J Clin Invest. 2017 Apr 03; 127(4):1225-1240. Choi D, Park E, Jung E, Seong YJ, Yoo J, Lee E, Hong M, Lee S, Ishida H, Burford J, Peti-Peterdi J, Adams RH, Srikanth S, Gwack Y, Chen CS, Vogel HJ, Koh CJ, Wong AK, Hong YK. PMID: 28263185; PMCID: PMC5373895.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    30. ORAI1 Activates Proliferation of Lymphatic Endothelial Cells in Response to Laminar Flow Through Krüppel-Like Factors 2 and 4. Circ Res. 2017 Apr 28; 120(9):1426-1439. Choi D, Park E, Jung E, Seong YJ, Hong M, Lee S, Burford J, Gyarmati G, Peti-Peterdi J, Srikanth S, Gwack Y, Koh CJ, Boriushkin E, Hamik A, Wong AK, Hong YK. PMID: 28167653; PMCID: PMC6300148.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    31. Immunological Disorders: Regulation of Ca2+ Signaling in T Lymphocytes. Adv Exp Med Biol. 2017; 993:397-424. Srikanth S, Woo JS, Sun Z, Gwack Y. PMID: 28900926; PMCID: PMC8957800.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    32. Ubiquitination of RORγt at Lysine 446 Limits Th17 Differentiation by Controlling Coactivator Recruitment. J Immunol. 2016 08 15; 197(4):1148-58. He Z, Wang F, Ma J, Sen S, Zhang J, Gwack Y, Zhou Y, Sun Z. PMID: 27430721; PMCID: PMC4976012.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    33. Orai1 promotes tumor progression by enhancing cancer stemness via NFAT signaling in oral/oropharyngeal squamous cell carcinoma. Oncotarget. 2016 Jul 12; 7(28):43239-43255. Lee SH, Rigas NK, Lee CR, Bang A, Srikanth S, Gwack Y, Kang MK, Kim RH, Park NH, Shin KH. PMID: 27259269; PMCID: PMC5190020.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    34. A large Rab GTPase family in a small GTPase world. Small GTPases. 2017 01 02; 8(1):43-48. Srikanth S, Woo JS, Gwack Y. PMID: 27221160; PMCID: PMC5331893.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    35. Orai1 mediates osteogenic differentiation via BMP signaling pathway in bone marrow mesenchymal stem cells. Biochem Biophys Res Commun. 2016 05 13; 473(4):1309-1314. Lee SH, Park Y, Song M, Srikanth S, Kim S, Kang MK, Gwack Y, Park NH, Kim RH, Shin KH. PMID: 27086849; PMCID: PMC4853278.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    36. A large Rab GTPase encoded by CRACR2A is a component of subsynaptic vesicles that transmit T cell activation signals. Sci Signal. 2016 Mar 22; 9(420):ra31. Srikanth S, Kim KD, Gao Y, Woo JS, Ghosh S, Calmettes G, Paz A, Abramson J, Jiang M, Gwack Y. PMID: 27016526; PMCID: PMC5013727.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    37. Junctophilin-4, a component of the endoplasmic reticulum-plasma membrane junctions, regulates Ca2+ dynamics in T cells. Proc Natl Acad Sci U S A. 2016 Mar 08; 113(10):2762-7. Woo JS, Srikanth S, Nishi M, Ping P, Takeshima H, Gwack Y. PMID: 26929330; PMCID: PMC4790987.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    38. Dental enamel cells express functional SOCE channels. Sci Rep. 2015 Oct 30; 5:15803. Nurbaeva MK, Eckstein M, Concepcion AR, Smith CE, Srikanth S, Paine ML, Gwack Y, Hubbard MJ, Feske S, Lacruz RS. PMID: 26515404; PMCID: PMC4626795.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    39. The Role of ORAI1 in the Odontogenic Differentiation of Human Dental Pulp Stem Cells. J Dent Res. 2015 Nov; 94(11):1560-7. Sohn S, Park Y, Srikanth S, Arai A, Song M, Yu B, Shin KH, Kang MK, Wang C, Gwack Y, Park NH, Kim RH. PMID: 26403672; PMCID: PMC4622325.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    40. The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4⁺ T cells. Nat Immunol. 2014 Nov; 15(11):1055-1063. Bertin S, Aoki-Nonaka Y, de Jong PR, Nohara LL, Xu H, Stanwood SR, Srikanth S, Lee J, To K, Abramson L, Yu T, Han T, Touma R, Li X, González-Navajas JM, Herdman S, Corr M, Fu G, Dong H, Gwack Y, Franco A, Jefferies WA, Raz E. PMID: 25282159; PMCID: PMC4843825.
      View in: PubMed   Mentions: 123     Fields:    Translation:HumansAnimalsCells
    41. Interplay between the oxidoreductase PDIA6 and microRNA-322 controls the response to disrupted endoplasmic reticulum calcium homeostasis. Sci Signal. 2014 Jun 10; 7(329):ra54. Groenendyk J, Peng Z, Dudek E, Fan X, Mizianty MJ, Dufey E, Urra H, Sepulveda D, Rojas-Rivera D, Lim Y, Kim DH, Baretta K, Srikanth S, Gwack Y, Ahnn J, Kaufman RJ, Lee SK, Hetz C, Kurgan L, Michalak M. PMID: 24917591; PMCID: PMC4984425.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    42. Methods to measure cytoplasmic and mitochondrial Ca(2+) concentration using Ca(2+)-sensitive dyes. Methods Enzymol. 2014; 543:1-20. Srikanth S, Kim KD, Gwack Y. PMID: 24924125.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    43. Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation. J Immunol. 2014 Jan 01; 192(1):110-22. Kim KD, Srikanth S, Tan YV, Yee MK, Jew M, Damoiseaux R, Jung ME, Shimizu S, An DS, Ribalet B, Waschek JA, Gwack Y. PMID: 24307733; PMCID: PMC3874217.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    44. Orai1-NFAT signalling pathway triggered by T cell receptor stimulation. Mol Cells. 2013 Mar; 35(3):182-94. Srikanth S, Gwack Y. PMID: 23483280; PMCID: PMC3887911.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    45. Regulation of CRAC channels by protein interactions and post-translational modification. Channels (Austin). 2013 Sep-Oct; 7(5):354-63. Srikanth S, Ribalet B, Gwack Y. PMID: 23454861; PMCID: PMC3893732.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    46. Molecular regulation of the pore component of CRAC channels, Orai1. Curr Top Membr. 2013; 71:181-207. Srikanth S, Gwack Y. PMID: 23890116.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    47. Measurement of intracellular Ca2+ concentration in single cells using ratiometric calcium dyes. Methods Mol Biol. 2013; 963:3-14. Srikanth S, Gwack Y. PMID: 23296601.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    48. Orai1, STIM1, and their associating partners. J Physiol. 2012 Sep 01; 590(17):4169-77. Srikanth S, Gwack Y. PMID: 22586216; PMCID: PMC3473276.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    49. Junctate is a Ca2+-sensing structural component of Orai1 and stromal interaction molecule 1 (STIM1). Proc Natl Acad Sci U S A. 2012 May 29; 109(22):8682-7. Srikanth S, Jew M, Kim KD, Yee MK, Abramson J, Gwack Y. PMID: 22586105; PMCID: PMC3365170.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    50. ORAI1 deficiency impairs activated T cell death and enhances T cell survival. J Immunol. 2011 Oct 01; 187(7):3620-30. Kim KD, Srikanth S, Yee MK, Mock DC, Lawson GW, Gwack Y. PMID: 21873530; PMCID: PMC3178683.
      View in: PubMed   Mentions: 44     Fields:    
    51. The third transmembrane segment of orai1 protein modulates Ca2+ release-activated Ca2+ (CRAC) channel gating and permeation properties. J Biol Chem. 2011 Oct 07; 286(40):35318-28. Srikanth S, Yee MK, Gwack Y, Ribalet B. PMID: 21865174; PMCID: PMC3186358.
      View in: PubMed   Mentions: 18     Fields:    
    52. Protein kinase D orchestrates the activation of DRAK2 in response to TCR-induced Ca2+ influx and mitochondrial reactive oxygen generation. J Immunol. 2011 Jan 15; 186(2):940-50. Newton RH, Leverrier S, Srikanth S, Gwack Y, Cahalan MD, Walsh CM. PMID: 21148796; PMCID: PMC3133617.
      View in: PubMed   Mentions: 11     Fields:    
    53. A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells. Nat Cell Biol. 2010 May; 12(5):436-46. Srikanth S, Jung HJ, Kim KD, Souda P, Whitelegge J, Gwack Y. PMID: 20418871; PMCID: PMC2875865.
      View in: PubMed   Mentions: 106     Fields:    
    54. The intracellular loop of Orai1 plays a central role in fast inactivation of Ca2+ release-activated Ca2+ channels. J Biol Chem. 2010 Feb 12; 285(7):5066-75. Srikanth S, Jung HJ, Ribalet B, Gwack Y. PMID: 20007711; PMCID: PMC2836109.
      View in: PubMed   Mentions: 36     Fields:    
    55. Viral Bcl-2-mediated evasion of autophagy aids chronic infection of gammaherpesvirus 68. PLoS Pathog. 2009 Oct; 5(10):e1000609. E X, Hwang S, Oh S, Lee JS, Jeong JH, Gwack Y, Kowalik TF, Sun R, Jung JU, Liang C. PMID: 19816569; PMCID: PMC2752191.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    56. Hair loss and defective T- and B-cell function in mice lacking ORAI1. Mol Cell Biol. 2008 Sep; 28(17):5209-22. Gwack Y, Srikanth S, Oh-Hora M, Hogan PG, Lamperti ED, Yamashita M, Gelinas C, Neems DS, Sasaki Y, Feske S, Prakriya M, Rajewsky K, Rao A. PMID: 18591248; PMCID: PMC2519726.
      View in: PubMed   Mentions: 136     Fields:    
    57. Dynamic movement of the calcium sensor STIM1 and the calcium channel Orai1 in activated T-cells: puncta and distal caps. Mol Biol Cell. 2008 Jul; 19(7):2802-17. Barr VA, Bernot KM, Srikanth S, Gwack Y, Balagopalan L, Regan CK, Helman DJ, Sommers CL, Oh-Hora M, Rao A, Samelson LE. PMID: 18448669; PMCID: PMC2441672.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansCells
    58. Signalling to transcription: store-operated Ca2+ entry and NFAT activation in lymphocytes. Cell Calcium. 2007 Aug; 42(2):145-56. Gwack Y, Feske S, Srikanth S, Hogan PG, Rao A. PMID: 17572487.
      View in: PubMed   Mentions: 125     Fields:    Translation:HumansAnimalsCells
    59. Biochemical and functional characterization of Orai proteins. J Biol Chem. 2007 Jun 01; 282(22):16232-43. Gwack Y, Srikanth S, Feske S, Cruz-Guilloty F, Oh-hora M, Neems DS, Hogan PG, Rao A. PMID: 17293345.
      View in: PubMed   Mentions: 144     Fields:    Translation:HumansAnimalsCells
    60. Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated calcium influx. Evidence for similarities in store-operated and calcium release-activated calcium channel components. J Biol Chem. 2007 Mar 23; 282(12):9105-16. Ong HL, Cheng KT, Liu X, Bandyopadhyay BC, Paria BC, Soboloff J, Pani B, Gwack Y, Srikanth S, Singh BB, Gill DL, Gill D, Ambudkar IS. PMID: 17224452; PMCID: PMC3309402.
      View in: PubMed   Mentions: 130     Fields:    
    61. Orai1 is an essential pore subunit of the CRAC channel. Nature. 2006 Sep 14; 443(7108):230-3. Prakriya M, Feske S, Gwack Y, Srikanth S, Rao A, Hogan PG. PMID: 16921383.
      View in: PubMed   Mentions: 495     Fields:    Translation:HumansCells
    62. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature. 2006 May 11; 441(7090):179-85. Feske S, Gwack Y, Prakriya M, Srikanth S, Puppel SH, Tanasa B, Hogan PG, Lewis RS, Daly M, Rao A. PMID: 16582901.
      View in: PubMed   Mentions: 845     Fields:    Translation:HumansAnimalsCells
    63. A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT. Nature. 2006 Jun 01; 441(7093):646-50. Gwack Y, Sharma S, Nardone J, Tanasa B, Iuga A, Srikanth S, Okamura H, Bolton D, Feske S, Hogan PG, Rao A. PMID: 16511445.
      View in: PubMed   Mentions: 141     Fields:    Translation:AnimalsCells
    64. Activation of CD21 and CD23 gene expression by Kaposi's sarcoma-associated herpesvirus RTA. J Virol. 2005 Apr; 79(8):4651-63. Chang H, Gwack Y, Kingston D, Souvlis J, Liang X, Means RE, Cesarman E, Hutt-Fletcher L, Jung JU. PMID: 15795251; PMCID: PMC1069543.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    65. Modulation of T-cell receptor signal transduction by herpesvirus signaling adaptor protein. Mol Cell Biol. 2004 Jun; 24(12):5369-82. Lee SH, Chung YH, Cho NH, Gwack Y, Feng P, Jung JU. PMID: 15169900; PMCID: PMC419894.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    66. Poly(ADP-ribose) polymerase 1 and Ste20-like kinase hKFC act as transcriptional repressors for gamma-2 herpesvirus lytic replication. Mol Cell Biol. 2003 Nov; 23(22):8282-94. Gwack Y, Nakamura H, Lee SH, Souvlis J, Yustein JT, Gygi S, Kung HJ, Jung JU. PMID: 14585985; PMCID: PMC262387.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    67. Global changes in Kaposi's sarcoma-associated virus gene expression patterns following expression of a tetracycline-inducible Rta transactivator. J Virol. 2003 Apr; 77(7):4205-20. Nakamura H, Lu M, Gwack Y, Souvlis J, Zeichner SL, Jung JU. PMID: 12634378; PMCID: PMC150665.
      View in: PubMed   Mentions: 187     Fields:    Translation:HumansCells
    68. Principal role of TRAP/mediator and SWI/SNF complexes in Kaposi's sarcoma-associated herpesvirus RTA-mediated lytic reactivation. Mol Cell Biol. 2003 Mar; 23(6):2055-67. Gwack Y, Baek HJ, Nakamura H, Lee SH, Meisterernst M, Roeder RG, Jung JU. PMID: 12612078; PMCID: PMC149486.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansCells
    69. Kaposi's sarcoma-associated herpesvirus K8 protein interacts with hSNF5. J Gen Virol. 2003 Mar; 84(Pt 3):665-676. Hwang S, Lee D, Gwack Y, Min H, Choe J. PMID: 12604819.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    70. Kaposi's sarcoma-associated herpesvirus open reading frame (ORF) 50 transactivates K8 and ORF57 promoters via heterogeneous response elements. Mol Cells. 2002 Oct 31; 14(2):185-91. Byun H, Gwack Y, Hwang S, Choe J. PMID: 12442889.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    71. Functional dissection of latency-associated nuclear antigen 1 of Kaposi's sarcoma-associated herpesvirus involved in latent DNA replication and transcription of terminal repeats of the viral genome. J Virol. 2002 Oct; 76(20):10320-31. Lim C, Sohn H, Lee D, Gwack Y, Choe J. PMID: 12239308; PMCID: PMC136563.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansCells
    72. Kaposi's Sarcoma-associated herpesvirus open reading frame 50 stimulates the transcriptional activity of STAT3. J Biol Chem. 2002 Feb 22; 277(8):6438-42. Gwack Y, Hwang S, Lim C, Won YS, Lee CH, Choe J. PMID: 11741976.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    73. The Kaposi's sarcoma-associated herpesvirus K8 protein interacts with CREB-binding protein (CBP) and represses CBP-mediated transcription. J Virol. 2001 Oct; 75(19):9509-16. Hwang S, Gwack Y, Byun H, Lim C, Choe J. PMID: 11533213; PMCID: PMC114518.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    74. Kaposi's sarcoma-associated herpesvirus open reading frame 50 represses p53-induced transcriptional activity and apoptosis. J Virol. 2001 Jul; 75(13):6245-8. Gwack Y, Hwang S, Byun H, Lim C, Kim JW, Choi EJ, Choe J. PMID: 11390631; PMCID: PMC114345.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    75. The transcriptional activity of cAMP response element-binding protein-binding protein is modulated by the latency associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus. J Biol Chem. 2001 Aug 17; 276(33):31016-22. Lim C, Gwack Y, Hwang S, Kim S, Choe J. PMID: 11425857.
      View in: PubMed   Mentions: 65     Fields:    Translation:Cells
    76. CREB-binding protein and histone deacetylase regulate the transcriptional activity of Kaposi's sarcoma-associated herpesvirus open reading frame 50. J Virol. 2001 Feb; 75(4):1909-17. Gwack Y, Byun H, Hwang S, Lim C, Choe J. PMID: 11160690; PMCID: PMC115137.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansCells
    77. The K-bZIP protein from Kaposi's sarcoma-associated herpesvirus interacts with p53 and represses its transcriptional activity. J Virol. 2000 Dec; 74(24):11977-82. Park J, Seo T, Hwang S, Lee D, Gwack Y, Choe J. PMID: 11090200; PMCID: PMC112483.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    78. Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) binds ATF4/CREB2 and inhibits its transcriptional activation activity. J Gen Virol. 2000 Nov; 81(Pt 11):2645-2652. Lim C, Sohn H, Gwack Y, Choe J. PMID: 11038375.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    79. RNA-Stimulated ATPase and RNA helicase activities and RNA binding domain of hepatitis G virus nonstructural protein 3. J Virol. 1999 Apr; 73(4):2909-15. Gwack Y, Yoo H, Song I, Choe J, Han JH. PMID: 10074139; PMCID: PMC104049.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    80. Mutational analysis of the hepatitis C virus RNA helicase. J Virol. 1997 Dec; 71(12):9400-9. Kim DW, Kim J, Gwack Y, Han JH, Choe J. PMID: 9371600; PMCID: PMC230244.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    81. DNA helicase activity of the hepatitis C virus nonstructural protein 3. Eur J Biochem. 1997 Nov 15; 250(1):47-54. Gwack Y, Kim DW, Han JH, Choe J. PMID: 9431989.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    82. Towards defining a minimal functional domain for NTPase and RNA helicase activities of the hepatitis C virus NS3 protein. Virus Res. 1997 May; 49(1):17-25. Kim DW, Gwack Y, Han JH, Choe J. PMID: 9178493.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    83. Characterization of RNA binding activity and RNA helicase activity of the hepatitis C virus NS3 protein. Biochem Biophys Res Commun. 1996 Aug 14; 225(2):654-9. Gwack Y, Kim DW, Han JH, Choe J. PMID: 8753814.
      View in: PubMed   Mentions: 36     Fields:    Translation:Cells
    84. C-terminal domain of the hepatitis C virus NS3 protein contains an RNA helicase activity. Biochem Biophys Res Commun. 1995 Oct 04; 215(1):160-6. Kim DW, Gwack Y, Han JH, Choe J. PMID: 7575585.
      View in: PubMed   Mentions: 87     Fields:    Translation:Cells
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