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Papazian, Diane M

Title(s)Professor, Physiology
Phone3108255766
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    Knock-in Mice with Spinocerebellar Ataxia Type 13 Mutations in Kcnc3 (Kv3.3) Gene
    NIH/NINDS R03NS082735Mar 1, 2013 - Feb 28, 2015
    Role: Principal Investigator
    Kv3.3 K+ Channels and Neuronal Excitability in Spinocerebellar Ataxia Type 13
    NIH/NINDS R01NS058500Dec 15, 2007 - Nov 30, 2012
    Role: Principal Investigator
    Quality Control of K+ Channel Biogenesis
    NIH/NIGMS R01GM066686Sep 2, 2002 - Aug 31, 2006
    Role: Principal Investigator
    Voltage-Dependent Activation in K+ Channels
    NIH/NIGMS R01GM043459Dec 1, 1989 - Nov 30, 2015
    Role: Principal Investigator
    DNA TRANSFORMATION OF DROSOPHILA WITH THE SHAKER GENE
    NIH/NINDS F32NS007706Jul 1, 1986
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Lin MA, Cannon SC, Papazian DM. Kv4.2 autism and epilepsy mutation enhances inactivation of closed channels but impairs access to inactivated state after opening. Proc Natl Acad Sci U S A. 2018 04 10; 115(15):E3559-E3568. PMID: 29581270.
      View in: PubMed
    2. Hsieh JY, Papazian DM. In Vivo Analysis of Potassium Channelopathies: Loose Patch Recording of Purkinje Cell Firing in Living, Awake Zebrafish. Methods Mol Biol. 2018; 1684:237-252. PMID: 29058196.
      View in: PubMed
    3. Hsieh JY, Ulrich B, Issa FA, Wan J, Papazian DM. Rapid development of Purkinje cell excitability, functional cerebellar circuit, and afferent sensory input to cerebellum in zebrafish. Front Neural Circuits. 2014; 8:147. PMID: 25565973.
      View in: PubMed
    4. Issa FA, Mock AF, Sagasti A, Papazian DM. Spinocerebellar ataxia type 13 mutation that is associated with disease onset in infancy disrupts axonal pathfinding during neuronal development. Dis Model Mech. 2012 Nov; 5(6):921-9. PMID: 22736459.
      View in: PubMed
    5. Minassian NA, Lin MC, Papazian DM. Altered Kv3.3 channel gating in early-onset spinocerebellar ataxia type 13. J Physiol. 2012 Apr 01; 590(7):1599-614. PMID: 22289912.
      View in: PubMed
    6. Lin MC, Hsieh JY, Mock AF, Papazian DM. R1 in the Shaker S4 occupies the gating charge transfer center in the resting state. J Gen Physiol. 2011 Aug; 138(2):155-63. PMID: 21788609.
      View in: PubMed
    7. Issa FA, Mazzochi C, Mock AF, Papazian DM. Spinocerebellar ataxia type 13 mutant potassium channel alters neuronal excitability and causes locomotor deficits in zebrafish. J Neurosci. 2011 May 04; 31(18):6831-41. PMID: 21543613.
      View in: PubMed
    8. Issa FA, O'Brien G, Kettunen P, Sagasti A, Glanzman DL, Papazian DM. Neural circuit activity in freely behaving zebrafish (Danio rerio). J Exp Biol. 2011 Mar 15; 214(Pt 6):1028-38. PMID: 21346131.
      View in: PubMed
    9. Mock AF, Richardson JL, Hsieh JY, Rinetti G, Papazian DM. Functional effects of spinocerebellar ataxia type 13 mutations are conserved in zebrafish Kv3.3 channels. BMC Neurosci. 2010 Aug 16; 11:99. PMID: 20712895.
      View in: PubMed
    10. Lin MC, Abramson J, Papazian DM. Transfer of ion binding site from ether-a-go-go to Shaker: Mg2+ binds to resting state to modulate channel opening. J Gen Physiol. 2010 May; 135(5):415-31. PMID: 20385745.
      View in: PubMed
    11. Koag MC, Papazian DM. Voltage-dependent conformational changes of KVAP S4 segment in bacterial membrane environment. Channels (Austin). 2009 Sep-Oct; 3(5):356-65. PMID: 19713752.
      View in: PubMed
    12. Papazian DM. S0, where is it? J Gen Physiol. 2008 Jun; 131(6):531-6. PMID: 18474638.
      View in: PubMed
    13. Lin MC, Papazian DM. Differences between ion binding to eag and HERG voltage sensors contribute to differential regulation of activation and deactivation gating. Channels (Austin). 2007 Nov-Dec; 1(6):429-37. PMID: 18690045.
      View in: PubMed
    14. Richardson J, Blunck R, Ge P, Selvin PR, Bezanilla F, Papazian DM, Correa AM. Distance measurements reveal a common topology of prokaryotic voltage-gated ion channels in the lipid bilayer. Proc Natl Acad Sci U S A. 2006 Oct 24; 103(43):15865-70. PMID: 17043236.
      View in: PubMed
    15. Waters MF, Minassian NA, Stevanin G, Figueroa KP, Bannister JP, Nolte D, Mock AF, Evidente VG, Fee DB, Müller U, Dürr A, Brice A, Papazian DM, Pulst SM. Mutations in voltage-gated potassium channel KCNC3 cause degenerative and developmental central nervous system phenotypes. Nat Genet. 2006 Apr; 38(4):447-51. PMID: 16501573.
      View in: PubMed
    16. Bannister JP, Chanda B, Bezanilla F, Papazian DM. Optical detection of rate-determining ion-modulated conformational changes of the ether-à-go-go K+ channel voltage sensor. Proc Natl Acad Sci U S A. 2005 Dec 20; 102(51):18718-23. PMID: 16339906.
      View in: PubMed
    17. Silverman WR, Bannister JP, Papazian DM. Binding site in eag voltage sensor accommodates a variety of ions and is accessible in closed channel. Biophys J. 2004 Nov; 87(5):3110-21. PMID: 15347589.
      View in: PubMed
    18. Myers MP, Khanna R, Lee EJ, Papazian DM. Voltage sensor mutations differentially target misfolded K+ channel subunits to proteasomal and non-proteasomal disposal pathways. FEBS Lett. 2004 Jun 18; 568(1-3):110-6. PMID: 15196930.
      View in: PubMed
    19. Papazian DM. BK channels: the spring between sensor and gate. Neuron. 2004 Jun 10; 42(5):699-701. PMID: 15182710.
      View in: PubMed
    20. Khanna R, Lee EJ, Papazian DM. Transient calnexin interaction confers long-term stability on folded K+ channel protein in the ER. J Cell Sci. 2004 Jun 15; 117(Pt 14):2897-908. PMID: 15161937.
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    21. Lainé M, Papazian DM, Roux B. Critical assessment of a proposed model of Shaker. FEBS Lett. 2004 Apr 30; 564(3):257-63. PMID: 15111106.
      View in: PubMed
    22. Lainé M, Lin MC, Bannister JP, Silverman WR, Mock AF, Roux B, Papazian DM. Atomic proximity between S4 segment and pore domain in Shaker potassium channels. Neuron. 2003 Jul 31; 39(3):467-81. PMID: 12895421.
      View in: PubMed
    23. Silverman WR, Roux B, Papazian DM. Structural basis of two-stage voltage-dependent activation in K+ channels. Proc Natl Acad Sci U S A. 2003 Mar 04; 100(5):2935-40. PMID: 12606713.
      View in: PubMed
    24. Papazian DM, Silverman WR, Lin MC, Tiwari-Woodruff SK, Tang CY. Structural organization of the voltage sensor in voltage-dependent potassium channels. Novartis Found Symp. 2002; 245:178-90; discussion 190-2, 261-4. PMID: 12027007.
      View in: PubMed
    25. Papazian DM. Potassium channels: some assembly required. Neuron. 1999 May; 23(1):7-10. PMID: 10402187.
      View in: PubMed