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Diane M Papazian

Title(s)Professor, Physiology
SchoolMedicine
Address760 Westwood Plaza 53-231
Los Angeles CA 90024
Phone3108255766
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    Knock-in Mice with Spinocerebellar Ataxia Type 13 Mutations in Kcnc3 (Kv3.3) Gene
    NIH/NINDS R03NS082735Mar 1, 2013 - Feb 28, 2015
    Role: Principal Investigator
    Kv3.3 K+ Channels and Neuronal Excitability in Spinocerebellar Ataxia Type 13
    NIH/NINDS R01NS058500Dec 15, 2007 - Nov 30, 2012
    Role: Principal Investigator
    Quality Control of K+ Channel Biogenesis
    NIH/NIGMS R01GM066686Sep 2, 2002 - Aug 31, 2006
    Role: Principal Investigator
    Voltage-Dependent Activation in K+ Channels
    NIH/NIGMS R01GM043459Dec 1, 1989 - Nov 30, 2015
    Role: Principal Investigator
    DNA TRANSFORMATION OF DROSOPHILA WITH THE SHAKER GENE
    NIH/NINDS F32NS007706Jul 1, 1986
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Infant and adult SCA13 mutations differentially affect Purkinje cell excitability, maturation, and viability in vivo. Elife. 2020 Jul 09; 9. Hsieh JY, Ulrich BN, Issa FA, Lin MA, Brown B, Papazian DM. PMID: 32644043.
      View in: PubMed   Mentions:    Fields:    
    2. Kv4.2 autism and epilepsy mutation enhances inactivation of closed channels but impairs access to inactivated state after opening. Proc Natl Acad Sci U S A. 2018 04 10; 115(15):E3559-E3568. Lin MA, Cannon SC, Papazian DM. PMID: 29581270.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    3. In Vivo Analysis of Potassium Channelopathies: Loose Patch Recording of Purkinje Cell Firing in Living, Awake Zebrafish. Methods Mol Biol. 2018; 1684:237-252. Hsieh JY, Papazian DM. PMID: 29058196.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    4. Rapid development of Purkinje cell excitability, functional cerebellar circuit, and afferent sensory input to cerebellum in zebrafish. Front Neural Circuits. 2014; 8:147. Hsieh JY, Ulrich B, Issa FA, Wan J, Papazian DM. PMID: 25565973.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    5. Spinocerebellar ataxia type 13 mutation that is associated with disease onset in infancy disrupts axonal pathfinding during neuronal development. Dis Model Mech. 2012 Nov; 5(6):921-9. Issa FA, Mock AF, Sagasti A, Papazian DM. PMID: 22736459.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    6. Altered Kv3.3 channel gating in early-onset spinocerebellar ataxia type 13. J Physiol. 2012 Apr 01; 590(7):1599-614. Minassian NA, Lin MC, Papazian DM. PMID: 22289912.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    7. R1 in the Shaker S4 occupies the gating charge transfer center in the resting state. J Gen Physiol. 2011 Aug; 138(2):155-63. Lin MC, Hsieh JY, Mock AF, Papazian DM. PMID: 21788609.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    8. Spinocerebellar ataxia type 13 mutant potassium channel alters neuronal excitability and causes locomotor deficits in zebrafish. J Neurosci. 2011 May 04; 31(18):6831-41. Issa FA, Mazzochi C, Mock AF, Papazian DM. PMID: 21543613.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    9. Neural circuit activity in freely behaving zebrafish (Danio rerio). J Exp Biol. 2011 Mar 15; 214(Pt 6):1028-38. Issa FA, O'Brien G, Kettunen P, Sagasti A, Glanzman DL, Papazian DM. PMID: 21346131.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    10. Functional effects of spinocerebellar ataxia type 13 mutations are conserved in zebrafish Kv3.3 channels. BMC Neurosci. 2010 Aug 16; 11:99. Mock AF, Richardson JL, Hsieh JY, Rinetti G, Papazian DM. PMID: 20712895.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    11. Transfer of ion binding site from ether-a-go-go to Shaker: Mg2+ binds to resting state to modulate channel opening. J Gen Physiol. 2010 May; 135(5):415-31. Lin MC, Abramson J, Papazian DM. PMID: 20385745.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    12. Voltage-dependent conformational changes of KVAP S4 segment in bacterial membrane environment. Channels (Austin). 2009 Sep-Oct; 3(5):356-65. Koag MC, Papazian DM. PMID: 19713752.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    13. S0, where is it? J Gen Physiol. 2008 Jun; 131(6):531-6. Papazian DM. PMID: 18474638.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    14. Differences between ion binding to eag and HERG voltage sensors contribute to differential regulation of activation and deactivation gating. Channels (Austin). 2007 Nov-Dec; 1(6):429-37. Lin MC, Papazian DM. PMID: 18690045.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    15. Distance measurements reveal a common topology of prokaryotic voltage-gated ion channels in the lipid bilayer. Proc Natl Acad Sci U S A. 2006 Oct 24; 103(43):15865-70. Richardson J, Blunck R, Ge P, Selvin PR, Bezanilla F, Papazian DM, Correa AM. PMID: 17043236.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    16. Mutations in voltage-gated potassium channel KCNC3 cause degenerative and developmental central nervous system phenotypes. Nat Genet. 2006 Apr; 38(4):447-51. Waters MF, Minassian NA, Stevanin G, Figueroa KP, Bannister JP, Nolte D, Mock AF, Evidente VG, Fee DB, Müller U, Dürr A, Brice A, Papazian DM, Pulst SM. PMID: 16501573.
      View in: PubMed   Mentions: 106     Fields:    Translation:HumansAnimalsCells
    17. Optical detection of rate-determining ion-modulated conformational changes of the ether-à-go-go K+ channel voltage sensor. Proc Natl Acad Sci U S A. 2005 Dec 20; 102(51):18718-23. Bannister JP, Chanda B, Bezanilla F, Papazian DM. PMID: 16339906.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    18. Binding site in eag voltage sensor accommodates a variety of ions and is accessible in closed channel. Biophys J. 2004 Nov; 87(5):3110-21. Silverman WR, Bannister JP, Papazian DM. PMID: 15347589.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    19. Voltage sensor mutations differentially target misfolded K+ channel subunits to proteasomal and non-proteasomal disposal pathways. FEBS Lett. 2004 Jun 18; 568(1-3):110-6. Myers MP, Khanna R, Lee EJ, Papazian DM. PMID: 15196930.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    20. BK channels: the spring between sensor and gate. Neuron. 2004 Jun 10; 42(5):699-701. Papazian DM. PMID: 15182710.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    21. Transient calnexin interaction confers long-term stability on folded K+ channel protein in the ER. J Cell Sci. 2004 Jun 15; 117(Pt 14):2897-908. Khanna R, Lee EJ, Papazian DM. PMID: 15161937.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    22. Critical assessment of a proposed model of Shaker. FEBS Lett. 2004 Apr 30; 564(3):257-63. Lainé M, Papazian DM, Roux B. PMID: 15111106.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    23. Atomic proximity between S4 segment and pore domain in Shaker potassium channels. Neuron. 2003 Jul 31; 39(3):467-81. Lainé M, Lin MC, Bannister JP, Silverman WR, Mock AF, Roux B, Papazian DM. PMID: 12895421.
      View in: PubMed   Mentions: 84     Fields:    Translation:AnimalsCells
    24. Structural basis of two-stage voltage-dependent activation in K+ channels. Proc Natl Acad Sci U S A. 2003 Mar 04; 100(5):2935-40. Silverman WR, Roux B, Papazian DM. PMID: 12606713.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    25. Structural organization of the voltage sensor in voltage-dependent potassium channels. Novartis Found Symp. 2002; 245:178-90; discussion 190-2, 261-4. Papazian DM, Silverman WR, Lin MC, Tiwari-Woodruff SK, Tang CY. PMID: 12027007.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    26. Potassium channels: some assembly required. Neuron. 1999 May; 23(1):7-10. Papazian DM. PMID: 10402187.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
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