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Cannon, Stephen Caldwell

Title(s)Professor, Physiology
Phone310-825-5882
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    Collapse Research 
    Collapse Research Activities and Funding
    Disease Pathogenesis and Modification for CaV1.1-Associated Hypokalemic Periodic
    NIH/NIAMS R01AR063182Jul 1, 2012 - Jun 30, 2022
    Role: Principal Investigator
    Molecular Physiology of Myotonia and Periodic Paralysis
    NIH/NIAMS R37AR042703Mar 10, 1994 - Sep 27, 2011
    Role: Principal Investigator
    Molecular Physiology of Neuromusclar Diseases
    NIH/NIAMS R01AR042703Mar 10, 1994 - Mar 31, 2008
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Cannon SC. Further evidence for shared genetic susceptibility in both sporadic and Thyrotoxic periodic paralysis. J Neurol Sci. 2020 Mar 20; 116794. PMID: 32229026.
      View in: PubMed
    2. Elia N, Nault T, McMillan HJ, Graham GE, Huang L, Cannon SC. Corrigendum: Myotonic Myopathy With Secondary Joint and Skeletal Anomalies From the c.2386C>G, p.L796V Mutation in SCN4A. Front Neurol. 2020; 11:181. PMID: 32265824.
      View in: PubMed
    3. Elia N, Nault T, McMillan HJ, Graham GE, Huang L, Cannon SC. Myotonic Myopathy With Secondary Joint and Skeletal Anomalies From the c.2386C>G, p.L769V Mutation in SCN4A. Front Neurol. 2020; 11:77. PMID: 32117035.
      View in: PubMed
    4. DiFranco M, Quinonez M, Dziedzic RM, Spokoyny AM, Cannon SC. A highly-selective chloride microelectrode based on a mercuracarborand anion carrier. Sci Rep. 2019 Dec 11; 9(1):18860. PMID: 31827130.
      View in: PubMed
    5. Heiny JA, Cannon SC, DiFranco M. A four-electrode method to study dynamics of ion activity and transport in skeletal muscle fibers. J Gen Physiol. 2019 Sep 02; 151(9):1146-1155. PMID: 31320390.
      View in: PubMed
    6. Elia N, Palmio J, Castañeda MS, Shieh PB, Quinonez M, Suominen T, Hanna MG, Männikkö R, Udd B, Cannon SC. Myasthenic congenital myopathy from recessive mutations at a single residue in NaV1.4. Neurology. 2019 03 26; 92(13):e1405-e1415. PMID: 30824560.
      View in: PubMed
    7. Mi W, Wu F, Quinonez M, DiFranco M, Cannon SC. Recovery from acidosis is a robust trigger for loss of force in murine hypokalemic periodic paralysis. J Gen Physiol. 2019 04 01; 151(4):555-566. PMID: 30733232.
      View in: PubMed
    8. Cannon SC. Skeletal muscle channelopathy: a new risk for sudden infant death syndrome. Lancet. 2018 04 14; 391(10129):1457-1458. PMID: 29605428.
      View in: PubMed
    9. Lin MA, Cannon SC, Papazian DM. Kv4.2 autism and epilepsy mutation enhances inactivation of closed channels but impairs access to inactivated state after opening. Proc Natl Acad Sci U S A. 2018 04 10; 115(15):E3559-E3568. PMID: 29581270.
      View in: PubMed
    10. Wu F, Quinonez M, DiFranco M, Cannon SC. Stac3 enhances expression of human CaV1.1 in Xenopus oocytes and reveals gating pore currents in HypoPP mutant channels. J Gen Physiol. 2018 03 05; 150(3):475-489. PMID: 29386226.
      View in: PubMed
    11. Cannon SC. Sodium Channelopathies of Skeletal Muscle. Handb Exp Pharmacol. 2018; 246:309-330. PMID: 28939973.
      View in: PubMed
    12. Cannon SC. An atypical CaV1.1 mutation reveals a common mechanism for hypokalemic periodic paralysis. J Gen Physiol. 2017 12 04; 149(12):1061-1064. PMID: 29138267.
      View in: PubMed
    13. Cannon SC. Mind the magnesium, in dantrolene suppression of malignant hyperthermia. Proc Natl Acad Sci U S A. 2017 05 02; 114(18):4576-4578. PMID: 28442565.
      View in: PubMed
    14. Wu F, Mi W, Fu Y, Struyk A, Cannon SC. Mice with an NaV1.4 sodium channel null allele have latent myasthenia, without susceptibility to periodic paralysis. Brain. 2016 06; 139(Pt 6):1688-99. PMID: 27048647.
      View in: PubMed
    15. Cannon SC. When all is lost…a severe myopathy with hypotonia from sodium channel mutations. Brain. 2016 Mar; 139(Pt 3):642-4. PMID: 26917582.
      View in: PubMed
    16. Cannon SC. Channelopathies of skeletal muscle excitability. Compr Physiol. 2015 Apr; 5(2):761-90. PMID: 25880512.
      View in: PubMed
    17. Mi W, Rybalchenko V, Cannon SC. Disrupted coupling of gating charge displacement to Na+ current activation for DIIS4 mutations in hypokalemic periodic paralysis. J Gen Physiol. 2014 Aug; 144(2):137-45. PMID: 25024265.
      View in: PubMed
    18. Wu F, Mi W, Cannon SC. Beneficial effects of bumetanide in a CaV1.1-R528H mouse model of hypokalaemic periodic paralysis. Brain. 2013 Dec; 136(Pt 12):3766-74. PMID: 24142145.
      View in: PubMed
    19. Wu F, Mi W, Cannon SC. Bumetanide prevents transient decreases in muscle force in murine hypokalemic periodic paralysis. Neurology. 2013 Mar 19; 80(12):1110-6. PMID: 23427324.
      View in: PubMed
    20. Wu F, Mi W, Hernández-Ochoa EO, Burns DK, Fu Y, Gray HF, Struyk AF, Schneider MF, Cannon SC. A calcium channel mutant mouse model of hypokalemic periodic paralysis. J Clin Invest. 2012 Dec; 122(12):4580-91. PMID: 23187123.
      View in: PubMed
    21. Wu F, Mi W, Burns DK, Fu Y, Gray HF, Struyk AF, Cannon SC. A sodium channel knockin mutant (NaV1.4-R669H) mouse model of hypokalemic periodic paralysis. J Clin Invest. 2011 Oct; 121(10):4082-94. PMID: 21881211.
      View in: PubMed
    22. Kudryashova E, Struyk A, Mokhonova E, Cannon SC, Spencer MJ. The common missense mutation D489N in TRIM32 causing limb girdle muscular dystrophy 2H leads to loss of the mutated protein in knock-in mice resulting in a Trim32-null phenotype. Hum Mol Genet. 2011 Oct 15; 20(20):3925-32. PMID: 21775502.
      View in: PubMed
    23. Cheng CJ, Lin SH, Lo YF, Yang SS, Hsu YJ, Cannon SC, Huang CL. Identification and functional characterization of Kir2.6 mutations associated with non-familial hypokalemic periodic paralysis. J Biol Chem. 2011 Aug 05; 286(31):27425-35. PMID: 21665951.
      View in: PubMed
    24. Francis DG, Rybalchenko V, Struyk A, Cannon SC. Leaky sodium channels from voltage sensor mutations in periodic paralysis, but not paramyotonia. Neurology. 2011 May 10; 76(19):1635-41. PMID: 21490317.
      View in: PubMed
    25. Cannon SC. Voltage-sensor mutations in channelopathies of skeletal muscle. J Physiol. 2010 Jun 01; 588(Pt 11):1887-95. PMID: 20156847.
      View in: PubMed
    26. Cannon SC, Bean BP. Sodium channels gone wild: resurgent current from neuronal and muscle channelopathies. J Clin Invest. 2010 Jan; 120(1):80-3. PMID: 20038809.
      View in: PubMed
    27. Cannon SC. Getting a charge out of periodic paralysis? Neurology. 2009 May 05; 72(18):1540-1. PMID: 19414720.
      View in: PubMed
    28. Struyk AF, Markin VS, Francis D, Cannon SC. Gating pore currents in DIIS4 mutations of NaV1.4 associated with periodic paralysis: saturation of ion flux and implications for disease pathogenesis. J Gen Physiol. 2008 Oct; 132(4):447-64. PMID: 18824591.
      View in: PubMed
    29. Hayward LJ, Kim JS, Lee MY, Zhou H, Kim JW, Misra K, Salajegheh M, Wu FF, Matsuda C, Reid V, Cros D, Hoffman EP, Renaud JM, Cannon SC, Brown RH. Targeted mutation of mouse skeletal muscle sodium channel produces myotonia and potassium-sensitive weakness. J Clin Invest. 2008 Apr; 118(4):1437-49. PMID: 18317596.
      View in: PubMed
    30. Struyk AF, Cannon SC. Paradoxical depolarization of BA2+- treated muscle exposed to low extracellular K+: insights into resting potential abnormalities in hypokalemic paralysis. Muscle Nerve. 2008 Mar; 37(3):326-37. PMID: 18041053.
      View in: PubMed
    31. Webb J, Cannon SC. Cold-induced defects of sodium channel gating in atypical periodic paralysis plus myotonia. Neurology. 2008 Mar 04; 70(10):755-61. PMID: 17898326.
      View in: PubMed
    32. Struyk AF, Cannon SC. A Na+ channel mutation linked to hypokalemic periodic paralysis exposes a proton-selective gating pore. J Gen Physiol. 2007 Jul; 130(1):11-20. PMID: 17591984.
      View in: PubMed
    33. Cannon SC. Pathomechanisms in channelopathies of skeletal muscle and brain. Annu Rev Neurosci. 2006; 29:387-415. PMID: 16776591.
      View in: PubMed
    34. Wu FF, Gordon E, Hoffman EP, Cannon SC. A C-terminal skeletal muscle sodium channel mutation associated with myotonia disrupts fast inactivation. J Physiol. 2005 Jun 01; 565(Pt 2):371-80. PMID: 15774523.
      View in: PubMed
    35. Struyk AF, Cannon SC. Slow inactivation does not block the aqueous accessibility to the outer pore of voltage-gated Na channels. J Gen Physiol. 2002 Oct; 120(4):509-16. PMID: 12356853.
      View in: PubMed
    36. Cannon SC. An expanding view for the molecular basis of familial periodic paralysis. Neuromuscul Disord. 2002 Aug; 12(6):533-43. PMID: 12117476.
      View in: PubMed