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Stephen Caldwell Cannon

Title(s)Professor, Physiology
SchoolMedicine
Address760 Westwood Plaza 53-231
Los Angeles CA 90024
Phone310-825-5882
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    Disease Pathogenesis and Modification for CaV1.1-Associated Hypokalemic Periodic
    NIH/NIAMS R01AR063182Jul 1, 2012 - Jun 30, 2022
    Role: Principal Investigator
    Molecular Physiology of Myotonia and Periodic Paralysis
    NIH/NIAMS R37AR042703Mar 10, 1994 - Sep 27, 2011
    Role: Principal Investigator
    Molecular Physiology of Neuromusclar Diseases
    NIH/NIAMS R01AR042703Mar 10, 1994 - Mar 31, 2008
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A role for external Ca2+ in maintaining muscle contractility in periodic paralysis. J Gen Physiol. 2020 07 06; 152(7). Cannon SC. PMID: 32463879.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    2. Further evidence for shared genetic susceptibility in both sporadic and Thyrotoxic periodic paralysis. J Neurol Sci. 2020 05 15; 412:116794. Cannon SC. PMID: 32229026.
      View in: PubMed   Mentions:    Fields:    
    3. Corrigendum: Myotonic Myopathy With Secondary Joint and Skeletal Anomalies From the c.2386C>G, p.L796V Mutation in SCN4A. Front Neurol. 2020; 11:181. Elia N, Nault T, McMillan HJ, Graham GE, Huang L, Cannon SC. PMID: 32265824.
      View in: PubMed   Mentions:
    4. Myotonic Myopathy With Secondary Joint and Skeletal Anomalies From the c.2386C>G, p.L769V Mutation in SCN4A. Front Neurol. 2020; 11:77. Elia N, Nault T, McMillan HJ, Graham GE, Huang L, Cannon SC. PMID: 32117035.
      View in: PubMed   Mentions:
    5. A highly-selective chloride microelectrode based on a mercuracarborand anion carrier. Sci Rep. 2019 12 11; 9(1):18860. DiFranco M, Quinonez M, Dziedzic RM, Spokoyny AM, Cannon SC. PMID: 31827130.
      View in: PubMed   Mentions:    Fields:    
    6. A four-electrode method to study dynamics of ion activity and transport in skeletal muscle fibers. J Gen Physiol. 2019 09 02; 151(9):1146-1155. Heiny JA, Cannon SC, DiFranco M. PMID: 31320390.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    7. Myasthenic congenital myopathy from recessive mutations at a single residue in NaV1.4. Neurology. 2019 03 26; 92(13):e1405-e1415. Elia N, Palmio J, Castañeda MS, Shieh PB, Quinonez M, Suominen T, Hanna MG, Männikkö R, Udd B, Cannon SC. PMID: 30824560.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    8. Recovery from acidosis is a robust trigger for loss of force in murine hypokalemic periodic paralysis. J Gen Physiol. 2019 04 01; 151(4):555-566. Mi W, Wu F, Quinonez M, DiFranco M, Cannon SC. PMID: 30733232.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    9. Skeletal muscle channelopathy: a new risk for sudden infant death syndrome. Lancet. 2018 04 14; 391(10129):1457-1458. Cannon SC. PMID: 29605428.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Kv4.2 autism and epilepsy mutation enhances inactivation of closed channels but impairs access to inactivated state after opening. Proc Natl Acad Sci U S A. 2018 04 10; 115(15):E3559-E3568. Lin MA, Cannon SC, Papazian DM. PMID: 29581270.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    11. Stac3 enhances expression of human CaV1.1 in Xenopus oocytes and reveals gating pore currents in HypoPP mutant channels. J Gen Physiol. 2018 03 05; 150(3):475-489. Wu F, Quinonez M, DiFranco M, Cannon SC. PMID: 29386226.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    12. Sodium Channelopathies of Skeletal Muscle. Handb Exp Pharmacol. 2018; 246:309-330. Cannon SC. PMID: 28939973.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    13. An atypical CaV1.1 mutation reveals a common mechanism for hypokalemic periodic paralysis. J Gen Physiol. 2017 12 04; 149(12):1061-1064. Cannon SC. PMID: 29138267.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    14. Mind the magnesium, in dantrolene suppression of malignant hyperthermia. Proc Natl Acad Sci U S A. 2017 05 02; 114(18):4576-4578. Cannon SC. PMID: 28442565.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    15. Mice with an NaV1.4 sodium channel null allele have latent myasthenia, without susceptibility to periodic paralysis. Brain. 2016 06; 139(Pt 6):1688-99. Wu F, Mi W, Fu Y, Struyk A, Cannon SC. PMID: 27048647.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    16. When all is lost…a severe myopathy with hypotonia from sodium channel mutations. Brain. 2016 Mar; 139(Pt 3):642-4. Cannon SC. PMID: 26917582.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    17. Channelopathies of skeletal muscle excitability. Compr Physiol. 2015 Apr; 5(2):761-90. Cannon SC. PMID: 25880512.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    18. Disrupted coupling of gating charge displacement to Na+ current activation for DIIS4 mutations in hypokalemic periodic paralysis. J Gen Physiol. 2014 Aug; 144(2):137-45. Mi W, Rybalchenko V, Cannon SC. PMID: 25024265.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    19. Beneficial effects of bumetanide in a CaV1.1-R528H mouse model of hypokalaemic periodic paralysis. Brain. 2013 Dec; 136(Pt 12):3766-74. Wu F, Mi W, Cannon SC. PMID: 24142145.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    20. Bumetanide prevents transient decreases in muscle force in murine hypokalemic periodic paralysis. Neurology. 2013 Mar 19; 80(12):1110-6. Wu F, Mi W, Cannon SC. PMID: 23427324.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    21. A calcium channel mutant mouse model of hypokalemic periodic paralysis. J Clin Invest. 2012 Dec; 122(12):4580-91. Wu F, Mi W, Hernández-Ochoa EO, Burns DK, Fu Y, Gray HF, Struyk AF, Schneider MF, Cannon SC. PMID: 23187123.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    22. A sodium channel knockin mutant (NaV1.4-R669H) mouse model of hypokalemic periodic paralysis. J Clin Invest. 2011 Oct; 121(10):4082-94. Wu F, Mi W, Burns DK, Fu Y, Gray HF, Struyk AF, Cannon SC. PMID: 21881211.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimals
    23. The common missense mutation D489N in TRIM32 causing limb girdle muscular dystrophy 2H leads to loss of the mutated protein in knock-in mice resulting in a Trim32-null phenotype. Hum Mol Genet. 2011 Oct 15; 20(20):3925-32. Kudryashova E, Struyk A, Mokhonova E, Cannon SC, Spencer MJ. PMID: 21775502.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    24. Identification and functional characterization of Kir2.6 mutations associated with non-familial hypokalemic periodic paralysis. J Biol Chem. 2011 Aug 05; 286(31):27425-35. Cheng CJ, Lin SH, Lo YF, Yang SS, Hsu YJ, Cannon SC, Huang CL. PMID: 21665951.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    25. Leaky sodium channels from voltage sensor mutations in periodic paralysis, but not paramyotonia. Neurology. 2011 May 10; 76(19):1635-41. Francis DG, Rybalchenko V, Struyk A, Cannon SC. PMID: 21490317.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    26. Voltage-sensor mutations in channelopathies of skeletal muscle. J Physiol. 2010 Jun 01; 588(Pt 11):1887-95. Cannon SC. PMID: 20156847.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    27. Sodium channels gone wild: resurgent current from neuronal and muscle channelopathies. J Clin Invest. 2010 Jan; 120(1):80-3. Cannon SC, Bean BP. PMID: 20038809.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    28. Getting a charge out of periodic paralysis? Neurology. 2009 May 05; 72(18):1540-1. Cannon SC. PMID: 19414720.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    29. Gating pore currents in DIIS4 mutations of NaV1.4 associated with periodic paralysis: saturation of ion flux and implications for disease pathogenesis. J Gen Physiol. 2008 Oct; 132(4):447-64. Struyk AF, Markin VS, Francis D, Cannon SC. PMID: 18824591.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    30. Targeted mutation of mouse skeletal muscle sodium channel produces myotonia and potassium-sensitive weakness. J Clin Invest. 2008 Apr; 118(4):1437-49. Hayward LJ, Kim JS, Lee MY, Zhou H, Kim JW, Misra K, Salajegheh M, Wu FF, Matsuda C, Reid V, Cros D, Hoffman EP, Renaud JM, Cannon SC, Brown RH. PMID: 18317596.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    31. Paradoxical depolarization of BA2+- treated muscle exposed to low extracellular K+: insights into resting potential abnormalities in hypokalemic paralysis. Muscle Nerve. 2008 Mar; 37(3):326-37. Struyk AF, Cannon SC. PMID: 18041053.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    32. Cold-induced defects of sodium channel gating in atypical periodic paralysis plus myotonia. Neurology. 2008 Mar 04; 70(10):755-61. Webb J, Cannon SC. PMID: 17898326.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    33. A Na+ channel mutation linked to hypokalemic periodic paralysis exposes a proton-selective gating pore. J Gen Physiol. 2007 Jul; 130(1):11-20. Struyk AF, Cannon SC. PMID: 17591984.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansAnimalsCells
    34. Pathomechanisms in channelopathies of skeletal muscle and brain. Annu Rev Neurosci. 2006; 29:387-415. Cannon SC. PMID: 16776591.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimals
    35. A C-terminal skeletal muscle sodium channel mutation associated with myotonia disrupts fast inactivation. J Physiol. 2005 Jun 01; 565(Pt 2):371-80. Wu FF, Gordon E, Hoffman EP, Cannon SC. PMID: 15774523.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    36. Slow inactivation does not block the aqueous accessibility to the outer pore of voltage-gated Na channels. J Gen Physiol. 2002 Oct; 120(4):509-16. Struyk AF, Cannon SC. PMID: 12356853.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    37. An expanding view for the molecular basis of familial periodic paralysis. Neuromuscul Disord. 2002 Aug; 12(6):533-43. Cannon SC. PMID: 12117476.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
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