Joshua Trachtenberg

Title(s)	Professor, Neurobiology
School	Medicine
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Overview

My lab is interested in understanding how our earliest sensory experiences pattern synaptic connections in the cortex and how this, in turn, shapes the function of neural circuitry. We explore this in the visual system, including primary visual cortex, higher visual cortical regions, superior colliculus, amygdala, and thalamus. Vision is the primary sense we use to evaluate social structures, individual faces, threats, and rewards. Our goal is to understand the molecular and cellular mechanisms by which early experiences instruct synpatic connectivity, network connectivity, and network function in cortical circuits. We also wish to understand how these experiential changes shape behavior. Our work employs sophisticated imaging and molecular techniques, including longitudinal multi-photon imaging of genetically encoded calcium indicators that are expressed in specific cell types, and single cell transcriptomics.

Research

Research Activities and Funding

Disinhibition and experience-dependent visual plasticity
NIH R01EY027407Jun 1, 2017 - May 31, 2021
Role: Co-Principal Investigator

Inhibitory Regulation of Neural Circuit Plasticity in Visual Cortex
NIH R01EY023871Sep 1, 2013 - Aug 31, 2023
Role: Principal Investigator

Imaging PTEN-induced changes in adult cortical structure and function in vivo
NIH R01MH082935Apr 1, 2010 - Jan 31, 2013
Role: Principal Investigator

Imaging Synaptic Plasticity in the Visual Cortex in Vivo
NIH R01EY016052Dec 1, 2004 - Sep 30, 2013
Role: Principal Investigator

PLASMINOGEN ACTIVATORS AND VISUAL CORTICAL DEVELOPMENT
NIH F32EY006824Aug 4, 1997
Role: Principal Investigator

Gene Targeting Approaches to Learning and Memory Studies
NIH U01AG013622Jul 25, 1995 - Mar 31, 2007
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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The Development of Receptive Field Tuning Properties in Mouse Binocular Primary Visual Cortex. J Neurosci. 2022 04 27; 42(17):3546-3556. Tan L, Ringach DL, Trachtenberg JT. PMID: 35296547; PMCID: PMC9053846.

View in: PubMed Mentions: Fields:
Neu Neurology
Translation:Animals Cells
Vision-dependent specification of cell types and function in the developing cortex. Cell. 2022 01 20; 185(2):311-327.e24. Cheng S, Butrus S, Tan L, Xu R, Sagireddy S, Trachtenberg JT, Shekhar K, Zipursky SL. PMID: 35063073; PMCID: PMC8813006.

View in: PubMed Mentions: 2 Fields:
Cel Cell Biology
Translation:Animals Cells
Vision is required for the formation of binocular neurons prior to the classical critical period. Curr Biol. 2021 10 11; 31(19):4305-4313.e5. Tan L, Ringach DL, Zipursky SL, Trachtenberg JT. PMID: 34411526; PMCID: PMC8511080.

View in: PubMed Mentions: 3 Fields:
Bio Biology
Translation:Cells
Vision Changes the Cellular Composition of Binocular Circuitry during the Critical Period. Neuron. 2020 11 25; 108(4):735-747.e6. Tan L, Tring E, Ringach DL, Zipursky SL, Trachtenberg JT. PMID: 33091339; PMCID: PMC7704707.

View in: PubMed Mentions: 9 Fields:
Neu Neurology
Translation:Animals Cells
State-Dependent Subnetworks of Parvalbumin-Expressing Interneurons in Neocortex. Cell Rep. 2019 02 26; 26(9):2282-2288.e3. Garcia-Junco-Clemente P, Tring E, Ringach DL, Trachtenberg JT. PMID: 30811979; PMCID: PMC6407626.

View in: PubMed Mentions: 10 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Animals Cells
Neuromodulatory control of localized dendritic spiking in critical period cortex. Nature. 2019 03; 567(7746):100-104. Yaeger CE, Ringach DL, Trachtenberg JT. PMID: 30787434; PMCID: PMC6405296.

View in: PubMed Mentions: 26 Fields:
Sci Science
Translation:Animals Cells
Local tuning biases in mouse primary visual cortex. J Neurophysiol. 2018 07 01; 120(1):274-280. Jimenez LO, Tring E, Trachtenberg JT, Ringach DL. PMID: 29668380; PMCID: PMC6093950.

View in: PubMed Mentions: 8 Fields:
Neu Neurology Phy Physiology
Translation:Animals Cells
Hotspots of dendritic spine turnover facilitate clustered spine addition and learning and memory. Nat Commun. 2018 01 29; 9(1):422. Frank AC, Huang S, Zhou M, Gdalyahu A, Kastellakis G, Silva TK, Lu E, Wen X, Poirazi P, Trachtenberg JT, Silva AJ. PMID: 29379017; PMCID: PMC5789055.

View in: PubMed Mentions: 59 Fields:
Bio Biology Sci Science
Translation:Animals Cells
An inhibitory pull-push circuit in frontal cortex. Nat Neurosci. 2017 Mar; 20(3):389-392. Garcia-Junco-Clemente P, Ikrar T, Tring E, Xu X, Ringach DL, Trachtenberg JT. PMID: 28114295; PMCID: PMC5967235.

View in: PubMed Mentions: 30 Fields:
Neu Neurology
Translation:Animals Cells
Pten and EphB4 regulate the establishment of perisomatic inhibition in mouse visual cortex. Nat Commun. 2016 09 09; 7:12829. Baohan A, Ikrar T, Tring E, Xu X, Trachtenberg JT. PMID: 27611660; PMCID: PMC5023968.

View in: PubMed Mentions: 6 Fields:
Bio Biology Sci Science
Translation:Animals Cells
Spatial clustering of tuning in mouse primary visual cortex. Nat Commun. 2016 08 02; 7:12270. Ringach DL, Mineault PJ, Tring E, Olivas ND, Garcia-Junco-Clemente P, Trachtenberg JT. PMID: 27481398; PMCID: PMC4974656.

View in: PubMed Mentions: 41 Fields:
Bio Biology Sci Science
Translation:Animals Cells
Enhanced Spatial Resolution During Locomotion and Heightened Attention in Mouse Primary Visual Cortex. J Neurosci. 2016 06 15; 36(24):6382-92. Mineault PJ, Tring E, Trachtenberg JT, Ringach DL. PMID: 27307228; PMCID: PMC4909779.

View in: PubMed Mentions: 49 Fields:
Neu Neurology
Translation:Animals Cells
Parvalbumin Interneurons: All Forest, No Trees. Neuron. 2015 Jul 15; 87(2):247-8. Trachtenberg JT. PMID: 26182410; PMCID: PMC6075815.

View in: PubMed Mentions: 5 Fields:
Neu Neurology
Translation:Animals Cells
Competition, inhibition, and critical periods of cortical plasticity. Curr Opin Neurobiol. 2015 Dec; 35:44-8. Trachtenberg JT. PMID: 26126153; PMCID: PMC5479701.

View in: PubMed Mentions: 18 Fields:
Bio Biology Neu Neurology
Translation:Humans Animals
Correction: The Autism Related Protein Contactin-Associated Protein-Like 2 (CNTNAP2) Stabilizes New Spines: An In Vivo Mouse Study. PLoS One. 2015; 10(5):e0129638. Gdalyahu A, Lazaro M, Penagarikano O, Golshani P, Trachtenberg JT, Geschwind DH. PMID: 26024526; PMCID: PMC4449228.

View in: PubMed Mentions: Fields:
Med Medicine (General)Sci Science
The Autism Related Protein Contactin-Associated Protein-Like 2 (CNTNAP2) Stabilizes New Spines: An In Vivo Mouse Study. PLoS One. 2015; 10(5):e0125633. Gdalyahu A, Lazaro M, Penagarikano O, Golshani P, Trachtenberg JT, Geschwind DH, Gescwind DH. PMID: 25951243; PMCID: PMC4423902.

View in: PubMed Mentions: 35 Fields:
Med Medicine (General)Sci Science
Translation:Animals Cells
Encoding and storage of spatial information in the retrosplenial cortex. Proc Natl Acad Sci U S A. 2014 Jun 10; 111(23):8661-6. Czajkowski R, Jayaprakash B, Wiltgen B, Rogerson T, Guzman-Karlsson MC, Barth AL, Trachtenberg JT, Silva AJ. PMID: 24912150; PMCID: PMC4060653.

View in: PubMed Mentions: 74 Fields:
Sci Science
Translation:Animals Cells
Overexpression of calcium-activated potassium channels underlies cortical dysfunction in a model of PTEN-associated autism. Proc Natl Acad Sci U S A. 2013 Nov 05; 110(45):18297-302. Garcia-Junco-Clemente P, Chow DK, Tring E, Lazaro MT, Trachtenberg JT, Golshani P. PMID: 24145404; PMCID: PMC3831440.

View in: PubMed Mentions: 13 Fields:
Sci Science
Translation:Humans Animals
A disinhibitory microcircuit initiates critical-period plasticity in the visual cortex. Nature. 2013 Sep 26; 501(7468):543-6. Kuhlman SJ, Olivas ND, Tring E, Ikrar T, Xu X, Trachtenberg JT. PMID: 23975100; PMCID: PMC3962838.

View in: PubMed Mentions: 195 Fields:
Sci Science
Translation:Animals Cells
Associative fear learning enhances sparse network coding in primary sensory cortex. Neuron. 2012 Jul 12; 75(1):121-32. Gdalyahu A, Tring E, Polack PO, Gruver R, Golshani P, Fanselow MS, Silva AJ, Trachtenberg JT. PMID: 22794266; PMCID: PMC3398404.

View in: PubMed Mentions: 43 Fields:
Neu Neurology
Translation:Animals
Pattern and not magnitude of neural activity determines dendritic spine stability in awake mice. Nat Neurosci. 2012 Jun 17; 15(7):949-51. Wyatt RM, Tring E, Trachtenberg JT. PMID: 22706266; PMCID: PMC3386353.

View in: PubMed Mentions: 13 Fields:
Neu Neurology
Translation:Animals Cells
Imaging neocortical neurons through a chronic cranial window. Cold Spring Harb Protoc. 2012 Jun 01; 2012(6):694-701. Holtmaat A, de Paola V, Wilbrecht L, Trachtenberg JT, Svoboda K, Portera-Cailliau C. PMID: 22661440.

View in: PubMed Mentions: 22 Fields:
Cli Clinical Laboratory Techniques
Translation:Animals Cells
Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities, and core autism-related deficits. Cell. 2011 Sep 30; 147(1):235-46. Peñagarikano O, Abrahams BS, Herman EI, Winden KD, Gdalyahu A, Dong H, Sonnenblick LI, Gruver R, Almajano J, Bragin A, Golshani P, Trachtenberg JT, Peles E, Geschwind DH. PMID: 21962519; PMCID: PMC3390029.

View in: PubMed Mentions: 439 Fields:
Cel Cell Biology
Translation:Humans Animals Cells
Fast-spiking interneurons have an initial orientation bias that is lost with vision. Nat Neurosci. 2011 Jul 12; 14(9):1121-3. Kuhlman SJ, Tring E, Trachtenberg JT. PMID: 21750548; PMCID: PMC3164933.

View in: PubMed Mentions: 59 Fields:
Neu Neurology
Translation:Animals Cells
The refinement of ipsilateral eye retinotopic maps is increased by removing the dominant contralateral eye in adult mice. PLoS One. 2010 Mar 29; 5(3):e9925. Smith SL, Trachtenberg JT. PMID: 20369001; PMCID: PMC2848025.

View in: PubMed Mentions: 5 Fields:
Med Medicine (General)Sci Science
Translation:Animals Cells
MDL constrained 3-D grayscale skeletonization algorithm for automated extraction of dendrites and spines from fluorescence confocal images. Neuroinformatics. 2009 Dec; 7(4):213-32. Yuan X, Trachtenberg JT, Potter SM, Roysam B. PMID: 20012509; PMCID: PMC2844542.

View in: PubMed Mentions: 26 Fields:
Med Medical Informatics Neu Neurology
Translation:Cells
Delta-catenin is required for the maintenance of neural structure and function in mature cortex in vivo. Neuron. 2009 Nov 12; 64(3):320-7. Matter C, Pribadi M, Liu X, Trachtenberg JT. PMID: 19914181; PMCID: PMC2840037.

View in: PubMed Mentions: 45 Fields:
Neu Neurology
Translation:Animals Cells
Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window. Nat Protoc. 2009; 4(8):1128-44. Holtmaat A, Bonhoeffer T, Chow DK, Chuckowree J, De Paola V, Hofer SB, Hübener M, Keck T, Knott G, Lee WC, Mostany R, Mrsic-Flogel TD, Nedivi E, Portera-Cailliau C, Svoboda K, Trachtenberg JT, Wilbrecht L. PMID: 19617885; PMCID: PMC3072839.

View in: PubMed Mentions: 474 Fields:
Cli Clinical Laboratory Techniques Sci Science
Translation:Animals Cells
A protocol for preparing GFP-labeled neurons previously imaged in vivo and in slice preparations for light and electron microscopic analysis. Nat Protoc. 2009; 4(8):1145-56. Knott GW, Holtmaat A, Trachtenberg JT, Svoboda K, Welker E. PMID: 19617886.

View in: PubMed Mentions: 35 Fields:
Cli Clinical Laboratory Techniques Sci Science
Translation:Animals Cells
Laminar and compartmental regulation of dendritic growth in mature cortex. Nat Neurosci. 2009 Feb; 12(2):116-8. Chow DK, Groszer M, Pribadi M, Machniki M, Carmichael ST, Liu X, Trachtenberg JT. PMID: 19151711; PMCID: PMC2842592.

View in: PubMed Mentions: 60 Fields:
Neu Neurology
Translation:Humans Animals Cells
Ipsilateral eye cortical maps are uniquely sensitive to binocular plasticity. J Neurophysiol. 2009 Feb; 101(2):855-61. Faguet J, Maranhao B, Smith SL, Trachtenberg JT. PMID: 19052109; PMCID: PMC2657065.

View in: PubMed Mentions: 16 Fields:
Neu Neurology Phy Physiology
Translation:Animals
Long-term, high-resolution imaging in the neocortex in vivo. CSH Protoc. 2008 Jan 01; 2008:pdb.prot4902. Chen BE, Trachtenberg JT, Holtmaat AJ, Svoboda K. PMID: 21356671.

View in: PubMed Mentions: 2
Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice. Proc Natl Acad Sci U S A. 2007 Nov 13; 104(46):18280-5. Li W, Zhou Y, Jentsch JD, Brown RA, Tian X, Ehninger D, Hennah W, Peltonen L, Lönnqvist J, Huttunen MO, Kaprio J, Trachtenberg JT, Silva AJ, Cannon TD. PMID: 17984054; PMCID: PMC2084334.

View in: PubMed Mentions: 102 Fields:
Sci Science
Translation:Animals
Regulation of the intermediate filament protein nestin at rodent neuromuscular junctions by innervation and activity. J Neurosci. 2007 May 30; 27(22):5948-57. Kang H, Tian L, Son YJ, Zuo Y, Procaccino D, Love F, Hayworth C, Trachtenberg J, Mikesh M, Sutton L, Ponomareva O, Mignone J, Enikolopov G, Rimer M, Thompson W. PMID: 17537965; PMCID: PMC6672248.

View in: PubMed Mentions: 27 Fields:
Neu Neurology
Translation:Animals Cells
Experience-dependent binocular competition in the visual cortex begins at eye opening. Nat Neurosci. 2007 Mar; 10(3):370-5. Smith SL, Trachtenberg JT. PMID: 17293862.

View in: PubMed Mentions: 85 Fields:
Neu Neurology
Translation:Animals Cells
Transient and persistent dendritic spines in the neocortex in vivo. Neuron. 2005 Jan 20; 45(2):279-91. Holtmaat AJ, Trachtenberg JT, Wilbrecht L, Shepherd GM, Zhang X, Knott GW, Svoboda K. PMID: 15664179.

View in: PubMed Mentions: 500 Fields:
Neu Neurology
Translation:Animals Cells
Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex. Nature. 2002 Dec 19-26; 420(6917):788-94. Trachtenberg JT, Chen BE, Knott GW, Feng G, Sanes JR, Welker E, Svoboda K. PMID: 12490942.

View in: PubMed Mentions: 721 Fields:
Sci Science
Translation:Animals Cells