Sanaz Memarzadeh

Title(s)Professor, Obstetrics and Gynecology
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    Collapse Biography 
    Collapse Awards and Honors
    Los Angeles County Board of Supervisors Recognition for ovarian cancer research and awareness
    West Hollywood City CouncilCertificate of Recognition for outstanding service and accomplishments in ovarian cancer research
    2022  - 2023Los Angeles Top Doctors
    2020  - 2023Super Doctors of California
    UCLA STAR Program  - 2023Distinguished Alumni

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    Collapse Overview
    At the G.O. Discovery Lab directed by Sanaz Memarzadeh, we are on a mission to help patients with gynecologic cancers. Our research is focused on two understudied and aggressive epithelial gynecologic cancers that affect thousands of women each year: ovarian and endometrial carcinomas. Making discoveries that will improve treatment of these diseases and potentially save lives is the ultimate goal of our work.

    In the G.O. Discovery Laboratory, we are taking a multifaceted approach, collaborating with other leading scientists to solve complex challenges. Explore below how we are working to make discoveries that may improve the lives of patients diagnosed with gynecologic cancers.

    Collapse Research 
    Collapse Research Activities and Funding
    Exploring Super Charged NK Cells as a Novel Cell-Based Immune Therapy in Targeting Platinum Resistant Ovarian Cancers
    VA-ORD Jul 1, 2024 - Jun 30, 2028
    Tracking and Reactivating Humoral Immunity Through Systems Serology
    The Mark Foundation For Cancer Research 20230235Jan 1, 2024 - Dec 31, 2025
    Role: Co-Investigator
    Targeting Unique Vulnerabilities in Neuroendocrine-like Ovarian Cancer Cells
    VA-ORD 1I0BX006019-01A2Jul 1, 2023 - Jun 30, 2027
    Role: Principal Investigator
    Combating Ovarian Cancer Using Stem Cell-Engineered Off-The-Shelf CAR-iNKT Cells
    CIRM DISC2-13505Aug 1, 2022 - Jul 31, 2024
    Role: Co-Investigator
    Reactivating p53 Function with a Novel Structure-Based Peptide as a Therapeutic Approach for Overcoming Platinum Resistance
    VA-ORD 5I01BX004651Jan 1, 2020 - Jun 30, 2024
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Percutaneous interstitial brachytherapy ablation for targeting oligometastatic gynecologic cancers. Brachytherapy. 2024 Mar 06. Lai TS, Francoeur A, Manrriquez E, Venkat P, Chang A, Douek M, Bahrami S, Raman SS, Memarzadeh S. PMID: 38453533.
      View in: PubMed   Mentions:    Fields:    
    2. [68Ga]Ga-FAPI-46 PET in a Borderline Ovarian Tumor. J Nucl Med. 2024 Jan 11. Unterrainer LM, Memarzadeh S, Moatamed NA, Benz MR, Czernin J, Calais J. PMID: 38212069.
      View in: PubMed   Mentions:    Fields:    
    3. Profiling ovarian cancer tumor and microenvironment during disease progression for cell-based immunotherapy design. iScience. 2023 Oct 20; 26(10):107952. Li YR, Ochoa CJ, Zhu Y, Kramer A, Wilson M, Fang Y, Chen Y, Singh T, Di Bernardo G, Zhu E, Lee D, Moatamed NA, Bando J, Zhou JJ, Memarzadeh S, Yang L. PMID: 37810241; PMCID: PMC10558812.
      View in: PubMed   Mentions: 1  
    4. Androgen receptor and its correlation with estrogen and progesterone receptors, aimed for identification of cases for future anti-androgen therapy in endometrial cancers. PLoS One. 2023; 18(9):e0291361. Moatamed NA, Vahdatshariatpanahi S, Gjertson DW, Sachs CR, Kang Y, Ostrzega N, Huang J, Memarzadeh S. PMID: 37725629; PMCID: PMC10508627.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Pathologic response to neoadjuvant chemotherapy in ovarian cancer and its association with outcome: A surrogate marker of survival. Gynecol Oncol. 2023 Oct; 177:173-179. Marsh LA, Kim TH, Zhang M, Kubalanza K, Treece CL, Chase D, Memarzadeh S, Salani R, Karlan B, Rao J, Konecny GE. PMID: 37716223.
      View in: PubMed   Mentions:    Fields:    
    6. Safety and efficacy of mirvetuximab soravtansine, a folate receptor alpha (FRα)-targeting antibody-drug conjugate (ADC), in combination with bevacizumab in patients with platinum-resistant ovarian cancer. Gynecol Oncol. 2023 03; 170:241-247. Gilbert L, Oaknin A, Matulonis UA, Mantia-Smaldone GM, Lim PC, Castro CM, Provencher D, Memarzadeh S, Method M, Wang J, Moore KN, O'Malley DM. PMID: 36736157.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    7. Expression of immune checkpoint regulators, programmed death-ligand 1 (PD-L1/PD-1), cytotoxic T lymphocyte antigen 4 (CTLA-4), and indolaimine-2, 3-deoxygenase (IDO) in uterine mesenchymal tumors. Diagn Pathol. 2022 Sep 14; 17(1):70. Samiei A, Gjertson DW, Memarzadeh S, Konecny GE, Moatamed NA. PMID: 36104728; PMCID: PMC9476344.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    8. Inability of ovarian cancers to upregulate their MHC-class I surface expression marks their aggressiveness and increased susceptibility to NK cell-mediated cytotoxicity. Cancer Immunol Immunother. 2022 Dec; 71(12):2929-2941. Chovatiya N, Kaur K, Huerta-Yepez S, Chen PC, Neal A, DiBernardo G, Gumrukcu S, Memarzadeh S, Jewett A. PMID: 35507102.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    9. cfTrack: A Method of Exome-Wide Mutation Analysis of Cell-free DNA to Simultaneously Monitor the Full Spectrum of Cancer Treatment Outcomes Including MRD, Recurrence, and Evolution. Clin Cancer Res. 2022 05 02; 28(9):1841-1853. Li S, Zeng W, Ni X, Zhou Y, Stackpole ML, Noor ZS, Yuan Z, Neal A, Memarzadeh S, Garon EB, Dubinett SM, Li W, Zhou XJ. PMID: 35149536; PMCID: PMC9126584.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    10. Efficacy of birinapant in combination with carboplatin in targeting platinum‑resistant epithelial ovarian cancers. Int J Oncol. 2022 Mar; 60(3). Singh T, Neal A, Dibernardo G, Raheseparian N, Moatamed NA, Memarzadeh S. PMID: 35191515; PMCID: PMC8878637.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    11. Combining ReACp53 with Carboplatin to Target High-Grade Serous Ovarian Cancers. Cancers (Basel). 2021 Nov 24; 13(23). Neal A, Lai T, Singh T, Rahseparian N, Grogan T, Elashoff D, Scott P, Pellegrini M, Memarzadeh S. PMID: 34885017; PMCID: PMC8657291.
      View in: PubMed   Mentions: 10  
    12. Management of Clitoral Melanoma Presenting as an Exophytic Clitoral Mass: A Case Report and Review of the Literature. Curr Oncol. 2021 10 21; 28(6):4264-4272. Szlachta-McGinn A, Chmielowski B, Kang Y, Raman S, Memarzadeh S. PMID: 34898540; PMCID: PMC8544559.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    13. Gynecologic tumor board: a radiologist's guide to vulvar and vaginal malignancies. Abdom Radiol (NY). 2021 12; 46(12):5669-5686. Chow L, Tsui BQ, Bahrami S, Masamed R, Memarzadeh S, Raman SS, Patel MK. PMID: 34435227; PMCID: PMC8590682.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    14. A rare case of vulvar extraskeletal myxoid chondrosarcoma: mimics and diagnostic clues. Autops Case Rep. 2021; 11:e2021322. Liou SS, Memarzadeh S, Dry SM, Graham RP, Moatamed NA. PMID: 34458187; PMCID: PMC8387072.
      View in: PubMed   Mentions:
    15. Targeting monoamine oxidase A-regulated tumor-associated macrophage polarization for cancer immunotherapy. Nat Commun. 2021 06 10; 12(1):3530. Wang YC, Wang X, Yu J, Ma F, Li Z, Zhou Y, Zeng S, Ma X, Li YR, Neal A, Huang J, To A, Clarke N, Memarzadeh S, Pellegrini M, Yang L. PMID: 34112755; PMCID: PMC8192781.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    16. Image-Guided Percutaneous Thermal Ablation of Oligometastatic Ovarian and Non-Ovarian Gynecologic Tumors. J Vasc Interv Radiol. 2021 05; 32(5):729-738. Yuan F, Wei SH, Konecny GE, Memarzadeh S, Suh RD, Sayre J, Lu DS, Raman SS. PMID: 33608192.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    17. Matched sequential tumor molecular profiling in solid malignancies may impact clinical practice. Cancer Genet. 2021 04; 252-253:73-79. Lai TS, Manrriquez E, Neal A, Memarzadeh S. PMID: 33434795.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    18. Exploring the Potential of Drug Response Assays for Precision Medicine in Ovarian Cancer. Int J Mol Sci. 2020 Dec 30; 22(1). Singh T, Neal AS, Moatamed NA, Memarzadeh S. PMID: 33396714; PMCID: PMC7794771.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    19. The uterine pathological features associated with sentinel lymph node metastasis in endometrial carcinomas. PLoS One. 2020; 15(11):e0242772. Kang Y, Kim TH, Gjertson DW, Cohen JG, Memarzadeh S, Moatamed NA. PMID: 33232380; PMCID: PMC7685478.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    20. 68Ga-FAPi-46 diffuse bilateral breast uptake in a patient with cervical cancer after hormonal stimulation. Eur J Nucl Med Mol Imaging. 2021 03; 48(3):924-926. Sonni I, Lee-Felker S, Memarzadeh S, Quinn MM, Mona CE, Lückerath K, Czernin J, Calais J. PMID: 32651662.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    21. An asymptomatic anterior vaginal wall endometrioma, a rare manifestation of endometriosis: A case report. Case Rep Womens Health. 2020 Jul; 27:e00210. Dilday EA, Lewis MS, Vahidi K, Memarzadeh S. PMID: 32551235; PMCID: PMC7287488.
      View in: PubMed   Mentions: 1  
    22. Expression of Stromal Progesterone Receptor and Differential Methylation Patterns in the Endometrium May Correlate with Response to Progesterone Therapy in Endometrial Complex Atypical Hyperplasia. Reprod Sci. 2020 09; 27(9):1778-1790. Neal AS, Nunez M, Lai T, Tosevska A, Morselli M, Amneus M, Zakhour M, Moatamed NA, Pellegrini M, Memarzadeh S. PMID: 32124398; PMCID: PMC7395059.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    23. A simple high-throughput approach identifies actionable drug sensitivities in patient-derived tumor organoids. Commun Biol. 2019; 2:78. Phan N, Hong JJ, Tofig B, Mapua M, Elashoff D, Moatamed NA, Huang J, Memarzadeh S, Damoiseaux R, Soragni A. PMID: 30820473; PMCID: PMC6389967.
      View in: PubMed   Mentions: 101  Translation:Humans
    24. Propagating Humanized BLT Mice for the Study of Human Immunology and Immunotherapy. Stem Cells Dev. 2016 12 15; 25(24):1863-1873. Smith DJ, Lin LJ, Moon H, Pham AT, Wang X, Liu S, Ji S, Rezek V, Shimizu S, Ruiz M, Lam J, Janzen DM, Memarzadeh S, Kohn DB, Zack JA, Kitchen SG, An DS, Yang L. PMID: 27608727; PMCID: PMC5165681.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    25. A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas. Cancer Cell. 2016 Jan 11; 29(1):90-103. Soragni A, Janzen DM, Johnson LM, Lindgren AG, Thai-Quynh Nguyen A, Tiourin E, Soriaga AB, Lu J, Jiang L, Faull KF, Pellegrini M, Memarzadeh S, Eisenberg DS. PMID: 26748848; PMCID: PMC4733364.
      View in: PubMed   Mentions: 151     Fields:    Translation:HumansAnimalsCells
    26. Tubal Ligation Induces Quiescence in the Epithelia of the Fallopian Tube Fimbria. Reprod Sci. 2015 Oct; 22(10):1262-71. Tiourin E, Velasco VS, Rosales MA, Sullivan PS, Janzen DM, Memarzadeh S. PMID: 25736327; PMCID: PMC5933088.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    27. Low levels of circulating estrogen sensitize PTEN-null endometrial tumors to PARP inhibition in vivo. Mol Cancer Ther. 2013 Dec; 12(12):2917-28. Janzen DM, Paik DY, Rosales MA, Yep B, Cheng D, Witte ON, Kayadibi H, Ryan CM, Jung ME, Faull K, Memarzadeh S. PMID: 24222661; PMCID: PMC3904550.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    28. Progesterone receptor signaling in the microenvironment of endometrial cancer influences its response to hormonal therapy. Cancer Res. 2013 Aug 01; 73(15):4697-710. Janzen DM, Rosales MA, Paik DY, Lee DS, Smith DA, Witte ON, Iruela-Arispe ML, Memarzadeh S. PMID: 23744837; PMCID: PMC3752407.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    29. Estrogen and progesterone together expand murine endometrial epithelial progenitor cells. Stem Cells. 2013 Apr; 31(4):808-22. Janzen DM, Cheng D, Schafenacker AM, Paik DY, Goldstein AS, Witte ON, Jaroszewicz A, Pellegrini M, Memarzadeh S. PMID: 23341289; PMCID: PMC3774116.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    30. Stem-like epithelial cells are concentrated in the distal end of the fallopian tube: a site for injury and serous cancer initiation. Stem Cells. 2012 Nov; 30(11):2487-97. Paik DY, Janzen DM, Schafenacker AM, Velasco VS, Shung MS, Cheng D, Huang J, Witte ON, Memarzadeh S. PMID: 22911892; PMCID: PMC4442093.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansCells
    31. Collaboration of Kras and androgen receptor signaling stimulates EZH2 expression and tumor-propagating cells in prostate cancer. Cancer Res. 2012 Sep 15; 72(18):4672-81. Cai H, Memarzadeh S, Stoyanova T, Beharry Z, Kraft AS, Witte ON. PMID: 22805308; PMCID: PMC3445707.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    32. Role of autonomous androgen receptor signaling in prostate cancer initiation is dichotomous and depends on the oncogenic signal. Proc Natl Acad Sci U S A. 2011 May 10; 108(19):7962-7. Memarzadeh S, Cai H, Janzen DM, Xin L, Lukacs R, Riedinger M, Zong Y, DeGendt K, Verhoeven G, Huang J, Witte ON. PMID: 21518863; PMCID: PMC3093518.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    33. Differential transformation capacity of Src family kinases during the initiation of prostate cancer. Proc Natl Acad Sci U S A. 2011 Apr 19; 108(16):6579-84. Cai H, Smith DA, Memarzadeh S, Lowell CA, Cooper JA, Witte ON. PMID: 21464326; PMCID: PMC3080985.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimals
    34. Bmi-1 is a crucial regulator of prostate stem cell self-renewal and malignant transformation. Cell Stem Cell. 2010 Dec 03; 7(6):682-93. Lukacs RU, Memarzadeh S, Wu H, Witte ON. PMID: 21112563; PMCID: PMC3019762.
      View in: PubMed   Mentions: 154     Fields:    Translation:AnimalsCells
    35. Cell-autonomous activation of the PI3-kinase pathway initiates endometrial cancer from adult uterine epithelium. Proc Natl Acad Sci U S A. 2010 Oct 05; 107(40):17298-303. Memarzadeh S, Zong Y, Janzen DM, Goldstein AS, Cheng D, Kurita T, Schafenacker AM, Huang J, Witte ON. PMID: 20855612; PMCID: PMC2951427.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    36. Basal epithelial stem cells are efficient targets for prostate cancer initiation. Proc Natl Acad Sci U S A. 2010 Feb 09; 107(6):2610-5. Lawson DA, Zong Y, Memarzadeh S, Xin L, Huang J, Witte ON. PMID: 20133806; PMCID: PMC2823887.
      View in: PubMed   Mentions: 152     Fields:    Translation:HumansAnimalsCells
    37. Non-Peutz-Jeghers syndrome associated ovarian sex cord tumor with annular tubules: a case report. Fertil Steril. 2009 Oct; 92(4):1497.e5-1497.e8. Nosov V, Park S, Rao J, Memarzadeh S. PMID: 19703688.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    38. Enhanced paracrine FGF10 expression promotes formation of multifocal prostate adenocarcinoma and an increase in epithelial androgen receptor. Cancer Cell. 2007 Dec; 12(6):572-85. Memarzadeh S, Xin L, Mulholland DJ, Mansukhani A, Wu H, Teitell MA, Witte ON. PMID: 18068633; PMCID: PMC2931420.
      View in: PubMed   Mentions: 105     Fields:    Translation:AnimalsCells
    39. Lymphovascular and perineural invasion in the parametria: a prognostic factor for early-stage cervical cancer. Obstet Gynecol. 2003 Sep; 102(3):612-9. Memarzadeh S, Natarajan S, Dandade DP, Ostrzega N, Saber PA, Busuttil A, Lentz SE, Berek JS. PMID: 12962952.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    40. Expression of colony-stimulating factor 1 receptor during prostate development and prostate cancer progression. Proc Natl Acad Sci U S A. 2002 Oct 29; 99(22):14404-9. Ide H, Seligson DB, Memarzadeh S, Xin L, Horvath S, Dubey P, Flick MB, Kacinski BM, Palotie A, Witte ON. PMID: 12381783; PMCID: PMC137896.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    41. Urokinase plasminogen activator receptor: Prognostic biomarker for endometrial cancer. Proc Natl Acad Sci U S A. 2002 Aug 06; 99(16):10647-52. Memarzadeh S, Kozak KR, Chang L, Natarajan S, Shintaku P, Reddy ST, Farias-Eisner R, Memarzedeh S. PMID: 12130664; PMCID: PMC125001.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
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