Profiles

At the G.O. Discovery Lab directed by Sanaz Memarzadeh, we are on a mission to help patients with gynecologic cancers. Our research is focused on two understudied and aggressive epithelial gynecologic cancers that affect thousands of women each year: ovarian and endometrial carcinomas. Making discoveries that will improve treatment of these diseases and potentially save lives is the ultimate goal of our work.

In the G.O. Discovery Laboratory, we are taking a multifaceted approach, collaborating with other leading scientists to solve complex challenges. See below how we are working to make discoveries that may improve the lives of patients diagnosed with gynecologic cancers.

• Explore unique cell types in ovarian and endometrial cancers causing relapse of disease and chemo resistance.
• High throughput drug screening and testing drug combinations using disease in a dish model to overcome ovarian cancer platinum resistance.
• Targeting therapy resistant ovarian cancers with cell-based immunotherapies using novel off the shelf immune cells such as iNKT and super charge NK cells.
• Development of physiologically relevant in vivo disease models with patient derived xenografts as a powerful platform for testing novel therapeutics.
• Defining the cellular lineage and therapeutic targets in ovarian and uterine carcinosarcomas