Frank U Alber

Title(s)Professor, MIMG
SchoolMedicine
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    Collapse Overview 
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    Our laboratory investigates the significance of spatial genome organization in governing gene expression, DNA replication, and cell differentiation. Our primary aim is to integrate genomics and microscopy data to gain a comprehensive understanding of the fundamental principles underlying chromosome folding and the allocation of genomic regions in relation to nuclear bodies. Additionally, we are actively developing techniques to map the spatial distributions of the proteome within the cell cytoplasm at a molecular level. This endeavor allows us to delve into the molecular architecture of subcellular compartments and track their dynamic alterations during the regulation of cellular processes

    Collapse Biography 
    Collapse education and training
    ETH Zürich, Zürich, SwitzerlandPhD
    Rockefeller University, New YorkPostdoc
    UCSF, San FranciscoPostdoc
    Collapse awards and honors
    PEW Charitable Trust2009  - 2012PEW Biomedical Research Scholar
    Alfred P. Sloan Foundation2009  - 2011Sloan Research Fellowship
    Arnold and Mabel Beckman Foundation2012  - 2016Beckman Young Investigator Award (BYI)
    NationalScience Foundation2012  - 2017NSF Career Development Award

    Collapse Research 
    Collapse Featured Publications
    Collapse research activities and funding
    Integrating imaging and multi-omics data to infer single-cell 3D genome structures
    NIH R01GM162977Mar 15, 2026 - Feb 28, 2030
    Role: Principal Investigator
    Multiscale Analyses of 4D Nucleome Structure and Function by Comprehensive Multimodal Data Integration
    NIH UM1HG011593Sep 22, 2020 - Jun 30, 2025
    Role: Co-Principal Investigator
    Mapping the 3D Genome Landscape
    NIH U54DK107981Sep 30, 2015 - Jul 31, 2021
    Role: Co-Principal Investigator
    Computational Methods Towards the Spatio-Temporal Organization of the Proteome
    NIH R01GM096089Sep 30, 2011 - Aug 31, 2018
    Role: Principal Investigator
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