Alice Soragni

Title(s)	Associate Professor-in-residence, Orthopaedic Surgery
School	Medicine
ORCID	0000-0002-6634-2885
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Overview

Websites

	Posts on Bluesky @soragnilab
	Soragni Lab Website

In The News

	UCLA Researchers Develop Organoid-Based Platform to Personalize Sarcoma Treatment (09/25/2024)
	The future of precision cancer therapy might be to try everything (02/14/2024)
	Improving organoid analysis with new developmental approaches (06/06/2023)
	Organoids open fresh paths to biomedical advances (12/14/2022)
	High-Throughput Technologies: Exploring Advances and Key Applications (11/09/2022)
	Developing organoids: an interview with Alice Soragni on 3D biology at the interface of cancer biology and protein aggregation (09/02/2021)
	Covid-19 has shuttered scientific labs. It could put a generation of researchers at risk (05/04/2020)
	Tumor Organoids Hold Promise for Personalizing Cancer Therapy (07/15/2019)
	Tumor ‘organoids’ may speed cancer treatment (12/17/2018)

ORNG Applications

Clinical Trials

Featured Publications

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

Altmetrics Details

PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Genetically Defined Organoid Models Reveal Mechanisms Driving Squamous Cell Neoplastic Evolution and Identify Potential Therapeutic Vulnerabilities. bioRxiv. 2025 Jan 22. Zhao H, Park YM, Zheng Y, Mao Q, Collet C, Hu B, Zhou T, Lin L, Wong S, Pan Y, Monreal AV, Sinha UK, Sedghizadeh P, Soragni A, Lin DC. PMID: 39896470; PMCID: PMC11785044.

View in: PubMed Mentions:
SUMO2 Inhibition Reverses Aberrant Epigenetic Rewiring Driven by Synovial Sarcoma Fusion Oncoproteins and Impairs Sarcomagenesis. bioRxiv. 2024 Sep 25. Iyer R, Deshpande A, Pedgaonkar A, Bala PA, Kim T, Brien GL, Finlay D, Vuori K, Soragni A, Murad R, Deshpande AJ. PMID: 39386552; PMCID: PMC11463515.

View in: PubMed Mentions:
The landscape of drug sensitivity and resistance in sarcoma. Cell Stem Cell. 2024 Oct 03; 31(10):1524-1542.e4. Al Shihabi A, Tebon PJ, Nguyen HTL, Chantharasamee J, Sartini S, Davarifar A, Jensen AY, Diaz-Infante M, Cox H, Gonzalez AE, Norris S, Sperry J, Nakashima J, Tavanaie N, Winata H, Fitz-Gibbon ST, Yamaguchi TN, Jeong JH, Dry S, Singh AS, Chmielowski B, Crompton JG, Kalbasi AK, Eilber FC, Hornicek F, Bernthal NM, Nelson SD, Boutros PC, Federman NC, Yanagawa J, Soragni A. PMID: 39305899.

View in: PubMed Mentions: 2 Fields:
Cel Cell Biology
Translation:Humans
Mutant p53 Misfolding and Aggregation Precedes Transformation into High-Grade Serous Ovarian Carcinoma. bioRxiv. 2024 Sep 18. Sartini S, Omholt L, Moatamed NA, Soragni A. PMID: 39345467; PMCID: PMC11430093.

View in: PubMed Mentions:
Roadmap for the next generation of Children's Oncology Group rhabdomyosarcoma trials. Cancer. 2024 Nov 15; 130(22):3785-3796. Metts JL, Aye JM, Crane JN, Oberoi S, Balis FM, Bhatia S, Bona K, Carleton B, Dasgupta R, Dela Cruz FS, Greenzang KA, Kaufman JL, Linardic CM, Parsons SK, Robertson-Tessi M, Rudzinski ER, Soragni A, Stewart E, Weigel BJ, Wolden SL, Weiss AR, Venkatramani R, Heske CM. PMID: 38941509; PMCID: PMC11511643.

View in: PubMed Mentions: Fields:
Neo Neoplasms
Translation:Humans
A platform for rapid patient-derived cutaneous neurofibroma organoid establishment and screening. Cell Rep Methods. 2024 May 20; 4(5):100772. Nguyen HTL, Kohl E, Bade J, Eng SE, Tosevska A, Al Shihabi A, Tebon PJ, Hong JJ, Dry S, Boutros PC, Panossian A, Gosline SJC, Soragni A. PMID: 38744290; PMCID: PMC11133839.

View in: PubMed Mentions: Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Humans
Membrane damage by MBP-1 is mediated by pore formation and amplified by mtDNA. Cell Rep. 2024 04 23; 43(4):114084. Gigon L, Müller P, Haenni B, Iacovache I, Barbo M, Gosheva G, Yousefi S, Soragni A, von Ballmoos C, Zuber B, Simon HU. PMID: 38583154.

View in: PubMed Mentions: 1 Fields:
Cel Cell Biology Mol Molecular Biology
Drug screening at single-organoid resolution via bioprinting and interferometry. Nat Commun. 2023 06 06; 14(1):3168. Tebon PJ, Wang B, Markowitz AL, Davarifar A, Tsai BL, Krawczuk P, Gonzalez AE, Sartini S, Murray GF, Nguyen HTL, Tavanaie N, Nguyen TL, Boutros PC, Teitell MA, Soragni A. PMID: 37280220; PMCID: PMC10244450.

View in: PubMed Mentions: 16 Fields:
Bio Biology Sci Science
Translation:Humans
Organoids. Nat Rev Methods Primers. 2022; 2. Zhao Z, Chen X, Dowbaj AM, Sljukic A, Bratlie K, Lin L, Fong ELS, Balachander GM, Chen Z, Soragni A, Huch M, Zeng YA, Wang Q, Yu H. PMID: 37325195; PMCID: PMC10270325.

View in: PubMed Mentions: 168
Personalized chordoma organoids for drug discovery studies. Sci Adv. 2022 02 18; 8(7):eabl3674. Al Shihabi A, Davarifar A, Nguyen HTL, Tavanaie N, Nelson SD, Yanagawa J, Federman N, Bernthal N, Hornicek F, Soragni A. PMID: 35171675; PMCID: PMC8849332.

View in: PubMed Mentions: 26 Fields:
Sci Science
Translation:Humans
Cervical organoids go viral. Cell Stem Cell. 2021 08 05; 28(8):1337-1338. Sartini S, Soragni A. PMID: 34358436.

View in: PubMed Mentions: 1 Fields:
Cel Cell Biology
Translation:Humans
Patient-Derived Tumor Organoid Rings for Histologic Characterization and High-Throughput Screening. STAR Protoc. 2020 09 18; 1(2). Nguyen HTL, Soragni A. PMID: 33043307; PMCID: PMC7546514.

View in: PubMed Mentions: 11 Fields:
Bio Biology Sci Science
Translation:Humans Cells
Of scientists and tweets. Nat Rev Cancer. 2019 09; 19(9):479-480. Soragni A, Maitra A. PMID: 31253855.

View in: PubMed Mentions: 4 Fields:
Neo Neoplasms
Translation:Humans
A simple high-throughput approach identifies actionable drug sensitivities in patient-derived tumor organoids. Commun Biol. 2019; 2:78. Phan N, Hong JJ, Tofig B, Mapua M, Elashoff D, Moatamed NA, Huang J, Memarzadeh S, Damoiseaux R, Soragni A. PMID: 30820473; PMCID: PMC6389967.

View in: PubMed Mentions: 121 Translation:Humans
Journal clubs in the time of preprints. Elife. 2018 06 11; 7. Avasthi P, Soragni A, Bembenek JN. PMID: 29889024; PMCID: PMC5995539.

View in: PubMed Mentions: 3 Fields:
Bio Biology
Translation:Humans
A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas. Cancer Cell. 2016 Jan 11; 29(1):90-103. Soragni A, Janzen DM, Johnson LM, Lindgren AG, Thai-Quynh Nguyen A, Tiourin E, Soriaga AB, Lu J, Jiang L, Faull KF, Pellegrini M, Memarzadeh S, Eisenberg DS. PMID: 26748848; PMCID: PMC4733364.

View in: PubMed Mentions: 163 Fields:
Neo Neoplasms
Translation:Humans Animals Cells
Toxicity of eosinophil MBP is repressed by intracellular crystallization and promoted by extracellular aggregation. Mol Cell. 2015 Mar 19; 57(6):1011-1021. Soragni A, Yousefi S, Stoeckle C, Soriaga AB, Sawaya MR, Kozlowski E, Schmid I, Radonjic-Hoesli S, Boutet S, Williams GJ, Messerschmidt M, Seibert MM, Cascio D, Zatsepin NA, Burghammer M, Riekel C, Colletier JP, Riek R, Eisenberg DS, Simon HU. PMID: 25728769; PMCID: PMC4904734.

View in: PubMed Mentions: 50 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Humans Animals Cells
Superresolution imaging of amyloid fibrils with binding-activated probes. ACS Chem Neurosci. 2013 Jul 17; 4(7):1057-61. Ries J, Udayar V, Soragni A, Hornemann S, Nilsson KP, Riek R, Hock C, Ewers H, Aguzzi AA, Rajendran L. PMID: 23594172; PMCID: PMC3715833.

View in: PubMed Mentions: 29 Fields:
Neu Neurology
Translation:Humans
On-surface aggregation of α-synuclein at nanomolar concentrations results in two distinct growth mechanisms. ACS Chem Neurosci. 2013 Mar 20; 4(3):408-17. Rabe M, Soragni A, Reynolds NP, Verdes D, Liverani E, Riek R, Seeger S. PMID: 23509977; PMCID: PMC3605820.

View in: PubMed Mentions: 23 Fields:
Neu Neurology
Translation:Cells
Mechanism of membrane interaction and disruption by α-synuclein. J Am Chem Soc. 2011 Dec 07; 133(48):19366-75. Reynolds NP, Soragni A, Rabe M, Verdes D, Liverani E, Handschin S, Riek R, Seeger S. PMID: 21978222.

View in: PubMed Mentions: 98 Fields:
Che Chemistry
Translation:Cells
The amyloid-Congo red interface at atomic resolution. Angew Chem Int Ed Engl. 2011 Jun 20; 50(26):5956-60. Schütz AK, Soragni A, Hornemann S, Aguzzi A, Ernst M, Böckmann A, Meier BH. PMID: 21591034.

View in: PubMed Mentions: 57 Fields:
Che Chemistry
Translation:Animals Cells
In vivo demonstration that alpha-synuclein oligomers are toxic. Proc Natl Acad Sci U S A. 2011 Mar 08; 108(10):4194-9. Winner B, Jappelli R, Maji SK, Desplats PA, Boyer L, Aigner S, Hetzer C, Loher T, Vilar M, Campioni S, Tzitzilonis C, Soragni A, Jessberger S, Mira H, Consiglio A, Pham E, Masliah E, Gage FH, Riek R. PMID: 21325059; PMCID: PMC3053976.

View in: PubMed Mentions: 671 Fields:
Sci Science
Translation:Animals Cells
Structural similarity between the prion domain of HET-s and a homologue can explain amyloid cross-seeding in spite of limited sequence identity. J Mol Biol. 2010 Sep 17; 402(2):311-25. Wasmer C, Zimmer A, Sabaté R, Soragni A, Saupe SJ, Ritter C, Meier BH. PMID: 20600104.

View in: PubMed Mentions: 20 Fields:
Mol Molecular Biology
Translation:Animals Cells
The mechanism of prion inhibition by HET-S. Mol Cell. 2010 Jun 25; 38(6):889-99. Greenwald J, Buhtz C, Ritter C, Kwiatkowski W, Choe S, Maddelein ML, Ness F, Cescau S, Soragni A, Leitz D, Saupe SJ, Riek R. PMID: 20620958; PMCID: PMC3507513.

View in: PubMed Mentions: 44 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Cells
A combined solid-state NMR and MD characterization of the stability and dynamics of the HET-s(218-289) prion in its amyloid conformation. Chembiochem. 2009 Jul 06; 10(10):1657-65. Lange A, Gattin Z, Van Melckebeke H, Wasmer C, Soragni A, van Gunsteren WF, Meier BH. PMID: 19504509.

View in: PubMed Mentions: 16 Fields:
Bio Biochemistry
Structural characterization of binding of Cu(II) to tau protein. Biochemistry. 2008 Oct 14; 47(41):10841-51. Soragni A, Zambelli B, Mukrasch MD, Biernat J, Jeganathan S, Griesinger C, Ciurli S, Mandelkow E, Zweckstetter M. PMID: 18803399.

View in: PubMed Mentions: 31 Fields:
Bio Biochemistry
Translation:Humans Cells
Infectious and noninfectious amyloids of the HET-s(218-289) prion have different NMR spectra. Angew Chem Int Ed Engl. 2008; 47(31):5839-41. Wasmer C, Soragni A, Sabaté R, Lange A, Riek R, Meier BH. PMID: 18548467.

View in: PubMed Mentions: 18 Fields:
Che Chemistry
Translation:Cells
Solution structure of selenoprotein W and NMR analysis of its interaction with 14-3-3 proteins. J Biol Chem. 2007 Dec 21; 282(51):37036-44. Aachmann FL, Fomenko DE, Soragni A, Gladyshev VN, Dikiy A. PMID: 17928294.

View in: PubMed Mentions: 20 Fields:
Bio Biochemistry
Translation:Animals Cells
In vitro analysis of protein-operator interactions of the NikR and fur metal-responsive regulators of coregulated genes in Helicobacter pylori. J Bacteriol. 2005 Nov; 187(22):7703-15. Delany I, Ieva R, Soragni A, Hilleringmann M, Rappuoli R, Scarlato V. PMID: 16267295; PMCID: PMC1280292.

View in: PubMed Mentions: 45 Fields:
Bac Bacteriology
Translation:Cells