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Alice Soragni

Title(s)Associate Professor-in-residence, Orthopaedic Surgery
SchoolMedicine
ORCID ORCID Icon0000-0002-6634-2885 Additional info
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Advancing preclinical biology for Ewing Sarcoma: an international effort. Mol Cancer Ther. 2025 Sep 05. Dela Cruz FS, Stewart EA, Surdez D, Daley JD, Soragni A, Tomazou EM, Alvarez-Perez J, Feinberg TY, Amatruda JF, Ganapathi SS, Ohm JE, Heske CM, Cohen-Gogo S, Pesic D, Nash JO, Shlien A, Roundhill EA, Burchill SA, Crompton BD, Lawlor ER, Loeb DM, Delattre O, Mora J, Scotlandi K, Reed DR, Grohar PJ, Grünewald TGP, Kovar H, Bailey KM. PMID: 40911901.
      View in: PubMed   Mentions:    Fields:    
    2. Patient-derived organoids reveal hypoxia-driven plasticity and therapeutic vulnerabilities in pheochromocytomas and paragangliomas. bioRxiv. 2025 Aug 23. Wang X, Calucho M, Estrada-Zuniga CM, Noureen M, Gonzalez-Cantu H, Mossuto S, Levi JN, Landry B, Guo Q, Rutherford KA, Cheng ZM, Sannajust A, Raghunathan S, Balaji S, da Conceicao VN, Norris S, Munawar SY, Nguyen HT, De Rosa J, Tomlinson G, Wu JX, Yeh MW, Livhits MJ, Vaidya A, Powers J, Lechan R, Tischler A, Zhang M, Graham P, Jimenez C, Peitzsch M, Bechmann N, Eisenhofer G, Ding Y, Kitano M, Soragni A, Dahia PLM. PMID: 40894599; PMCID: PMC12393577.
      View in: PubMed   Mentions:
    3. Targeting SUMO2 reverses aberrant epigenetic rewiring driven by SS18::SSX fusion oncoproteins and impairs sarcomagenesis. EMBO J. 2025 Sep; 44(18):4984-5004. Iyer R, Deshpande A, Pedgaonkar A, Bala PA, Kim T, Brien GL, Finlay D, Vuori K, Soragni A, Wetterstein HI, Murad R, Deshpande AJ. PMID: 40804185; PMCID: PMC12436642.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. New Approaches to Investigate Novel Agents in Ewing Sarcoma: A Report From the Children's Oncology Group Bone Tumor Committee. Pediatr Blood Cancer. 2025 Oct; 72(10):e31917. Daley JD, Whiteway SL, Heske CM, Dela Cruz FS, Whittle SB, Cohen-Gogo S, Collier AB, Gupta A, Ohm J, Clark A, Soragni A, Lawlor E, Setty B, Grohar PJ, Janeway K, Reed DR, Slotkin EK, Bailey KM. PMID: 40879325.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Prioritization of novel agents for further investigation in pediatric non-rhabdomyosarcoma soft tissue sarcomas: A report from the Children's Oncology Group. Eur J Cancer. 2025 Aug 26; 226:115600. Crane JN, Douglass DP, Oberoi S, Collins NB, Gupta A, Metts JL, Avutu V, Dela Cruz FS, Davis JL, Federman NC, Hiniker SM, Laetsch TW, Linardic CM, Navid F, Saab R, Shulman DS, Shern JF, Soragni A, Stewart EA, Terezakis S, Weigel BJ, Weiss AR. PMID: 40651390; PMCID: PMC12409922.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Acquired resistance in cancer: towards targeted therapeutic strategies. Nat Rev Cancer. 2025 Jun 03. Soragni A, Knudsen ES, O'Connor TN, Tognon CE, Tyner JW, Gini B, Kim D, Bivona TG, Zang X, Witkiewicz AK, Goodrich DW, Jiang D, Gammon ST, Willey CD, Boutros PC, Sandulache VC, Osman AA, Myers JN, Mehla K, Singh PK, Chan KS, Gao H, Marathe H, National Cancer Institute (NCI) Acquired Resistance to Therapy Network (ARTNet). PMID: 40461793.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    7. Genetically Defined Organoid Models Reveal Mechanisms Driving Squamous Cell Neoplastic Evolution and Identify Potential Therapeutic Vulnerabilities. bioRxiv. 2025 Jan 22. Zhao H, Park YM, Zheng Y, Mao Q, Collet C, Hu B, Zhou T, Lin L, Wong S, Pan Y, Monreal AV, Sinha UK, Sedghizadeh P, Soragni A, Lin DC. PMID: 39896470; PMCID: PMC11785044.
      View in: PubMed   Mentions:
    8. SUMO2 Inhibition Reverses Aberrant Epigenetic Rewiring Driven by Synovial Sarcoma Fusion Oncoproteins and Impairs Sarcomagenesis. bioRxiv. 2024 Sep 25. Iyer R, Deshpande A, Pedgaonkar A, Bala PA, Kim T, Brien GL, Finlay D, Vuori K, Soragni A, Murad R, Deshpande AJ. PMID: 39386552; PMCID: PMC11463515.
      View in: PubMed   Mentions:
    9. The landscape of drug sensitivity and resistance in sarcoma. Cell Stem Cell. 2024 Oct 03; 31(10):1524-1542.e4. Al Shihabi A, Tebon PJ, Nguyen HTL, Chantharasamee J, Sartini S, Davarifar A, Jensen AY, Diaz-Infante M, Cox H, Gonzalez AE, Norris S, Sperry J, Nakashima J, Tavanaie N, Winata H, Fitz-Gibbon ST, Yamaguchi TN, Jeong JH, Dry S, Singh AS, Chmielowski B, Crompton JG, Kalbasi AK, Eilber FC, Hornicek F, Bernthal NM, Nelson SD, Boutros PC, Federman NC, Yanagawa J, Soragni A. PMID: 39305899; PMCID: PMC12318355.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    10. Mutant p53 Misfolding and Aggregation Precedes Transformation into High-Grade Serous Ovarian Carcinoma. bioRxiv. 2024 Sep 18. Sartini S, Omholt L, Moatamed NA, Soragni A. PMID: 39345467; PMCID: PMC11430093.
      View in: PubMed   Mentions:
    11. Roadmap for the next generation of Children's Oncology Group rhabdomyosarcoma trials. Cancer. 2024 Nov 15; 130(22):3785-3796. Metts JL, Aye JM, Crane JN, Oberoi S, Balis FM, Bhatia S, Bona K, Carleton B, Dasgupta R, Dela Cruz FS, Greenzang KA, Kaufman JL, Linardic CM, Parsons SK, Robertson-Tessi M, Rudzinski ER, Soragni A, Stewart E, Weigel BJ, Wolden SL, Weiss AR, Venkatramani R, Heske CM. PMID: 38941509; PMCID: PMC11511643.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    12. A platform for rapid patient-derived cutaneous neurofibroma organoid establishment and screening. Cell Rep Methods. 2024 May 20; 4(5):100772. Nguyen HTL, Kohl E, Bade J, Eng SE, Tosevska A, Al Shihabi A, Tebon PJ, Hong JJ, Dry S, Boutros PC, Panossian A, Gosline SJC, Soragni A. PMID: 38744290; PMCID: PMC11133839.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    13. Membrane damage by MBP-1 is mediated by pore formation and amplified by mtDNA. Cell Rep. 2024 04 23; 43(4):114084. Gigon L, Müller P, Haenni B, Iacovache I, Barbo M, Gosheva G, Yousefi S, Soragni A, von Ballmoos C, Zuber B, Simon HU. PMID: 38583154.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    14. Drug screening at single-organoid resolution via bioprinting and interferometry. Nat Commun. 2023 06 06; 14(1):3168. Tebon PJ, Wang B, Markowitz AL, Davarifar A, Tsai BL, Krawczuk P, Gonzalez AE, Sartini S, Murray GF, Nguyen HTL, Tavanaie N, Nguyen TL, Boutros PC, Teitell MA, Soragni A. PMID: 37280220; PMCID: PMC10244450.
      View in: PubMed   Mentions: 41     Fields:    Translation:Humans
    15. Organoids. Nat Rev Methods Primers. 2022; 2. Zhao Z, Chen X, Dowbaj AM, Sljukic A, Bratlie K, Lin L, Fong ELS, Balachander GM, Chen Z, Soragni A, Huch M, Zeng YA, Wang Q, Yu H. PMID: 37325195; PMCID: PMC10270325.
      View in: PubMed   Mentions: 307  
    16. Personalized chordoma organoids for drug discovery studies. Sci Adv. 2022 02 18; 8(7):eabl3674. Al Shihabi A, Davarifar A, Nguyen HTL, Tavanaie N, Nelson SD, Yanagawa J, Federman N, Bernthal N, Hornicek F, Soragni A. PMID: 35171675; PMCID: PMC8849332.
      View in: PubMed   Mentions: 45     Fields:    Translation:Humans
    17. Cervical organoids go viral. Cell Stem Cell. 2021 08 05; 28(8):1337-1338. Sartini S, Soragni A. PMID: 34358436.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    18. Patient-Derived Tumor Organoid Rings for Histologic Characterization and High-Throughput Screening. STAR Protoc. 2020 09 18; 1(2). Nguyen HTL, Soragni A. PMID: 33043307; PMCID: PMC7546514.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    19. Of scientists and tweets. Nat Rev Cancer. 2019 09; 19(9):479-480. Soragni A, Maitra A. PMID: 31253855.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    20. A simple high-throughput approach identifies actionable drug sensitivities in patient-derived tumor organoids. Commun Biol. 2019; 2:78. Phan N, Hong JJ, Tofig B, Mapua M, Elashoff D, Moatamed NA, Huang J, Memarzadeh S, Damoiseaux R, Soragni A. PMID: 30820473; PMCID: PMC6389967.
      View in: PubMed   Mentions: 139  Translation:Humans
    21. Journal clubs in the time of preprints. Elife. 2018 06 11; 7. Avasthi P, Soragni A, Bembenek JN. PMID: 29889024; PMCID: PMC5995539.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    22. A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas. Cancer Cell. 2016 Jan 11; 29(1):90-103. Soragni A, Janzen DM, Johnson LM, Lindgren AG, Thai-Quynh Nguyen A, Tiourin E, Soriaga AB, Lu J, Jiang L, Faull KF, Pellegrini M, Memarzadeh S, Eisenberg DS. PMID: 26748848; PMCID: PMC4733364.
      View in: PubMed   Mentions: 176     Fields:    Translation:HumansAnimalsCells
    23. Toxicity of eosinophil MBP is repressed by intracellular crystallization and promoted by extracellular aggregation. Mol Cell. 2015 Mar 19; 57(6):1011-1021. Soragni A, Yousefi S, Stoeckle C, Soriaga AB, Sawaya MR, Kozlowski E, Schmid I, Radonjic-Hoesli S, Boutet S, Williams GJ, Messerschmidt M, Seibert MM, Cascio D, Zatsepin NA, Burghammer M, Riekel C, Colletier JP, Riek R, Eisenberg DS, Simon HU. PMID: 25728769; PMCID: PMC4904734.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    24. Superresolution imaging of amyloid fibrils with binding-activated probes. ACS Chem Neurosci. 2013 Jul 17; 4(7):1057-61. Ries J, Udayar V, Soragni A, Hornemann S, Nilsson KP, Riek R, Hock C, Ewers H, Aguzzi AA, Rajendran L. PMID: 23594172; PMCID: PMC3715833.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    25. On-surface aggregation of α-synuclein at nanomolar concentrations results in two distinct growth mechanisms. ACS Chem Neurosci. 2013 Mar 20; 4(3):408-17. Rabe M, Soragni A, Reynolds NP, Verdes D, Liverani E, Riek R, Seeger S. PMID: 23509977; PMCID: PMC3605820.
      View in: PubMed   Mentions: 25     Fields:    Translation:Cells
    26. Mechanism of membrane interaction and disruption by α-synuclein. J Am Chem Soc. 2011 Dec 07; 133(48):19366-75. Reynolds NP, Soragni A, Rabe M, Verdes D, Liverani E, Handschin S, Riek R, Seeger S. PMID: 21978222.
      View in: PubMed   Mentions: 107     Fields:    Translation:Cells
    27. The amyloid-Congo red interface at atomic resolution. Angew Chem Int Ed Engl. 2011 Jun 20; 50(26):5956-60. Schütz AK, Soragni A, Hornemann S, Aguzzi A, Ernst M, Böckmann A, Meier BH. PMID: 21591034.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    28. In vivo demonstration that alpha-synuclein oligomers are toxic. Proc Natl Acad Sci U S A. 2011 Mar 08; 108(10):4194-9. Winner B, Jappelli R, Maji SK, Desplats PA, Boyer L, Aigner S, Hetzer C, Loher T, Vilar M, Campioni S, Tzitzilonis C, Soragni A, Jessberger S, Mira H, Consiglio A, Pham E, Masliah E, Gage FH, Riek R. PMID: 21325059; PMCID: PMC3053976.
      View in: PubMed   Mentions: 727     Fields:    Translation:AnimalsCells
    29. Structural similarity between the prion domain of HET-s and a homologue can explain amyloid cross-seeding in spite of limited sequence identity. J Mol Biol. 2010 Sep 17; 402(2):311-25. Wasmer C, Zimmer A, Sabaté R, Soragni A, Saupe SJ, Ritter C, Meier BH. PMID: 20600104.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    30. The mechanism of prion inhibition by HET-S. Mol Cell. 2010 Jun 25; 38(6):889-99. Greenwald J, Buhtz C, Ritter C, Kwiatkowski W, Choe S, Maddelein ML, Ness F, Cescau S, Soragni A, Leitz D, Saupe SJ, Riek R. PMID: 20620958; PMCID: PMC3507513.
      View in: PubMed   Mentions: 49     Fields:    Translation:Cells
    31. A combined solid-state NMR and MD characterization of the stability and dynamics of the HET-s(218-289) prion in its amyloid conformation. Chembiochem. 2009 Jul 06; 10(10):1657-65. Lange A, Gattin Z, Van Melckebeke H, Wasmer C, Soragni A, van Gunsteren WF, Meier BH. PMID: 19504509.
      View in: PubMed   Mentions: 17     Fields:    
    32. Structural characterization of binding of Cu(II) to tau protein. Biochemistry. 2008 Oct 14; 47(41):10841-51. Soragni A, Zambelli B, Mukrasch MD, Biernat J, Jeganathan S, Griesinger C, Ciurli S, Mandelkow E, Zweckstetter M. PMID: 18803399.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    33. Infectious and noninfectious amyloids of the HET-s(218-289) prion have different NMR spectra. Angew Chem Int Ed Engl. 2008; 47(31):5839-41. Wasmer C, Soragni A, Sabaté R, Lange A, Riek R, Meier BH. PMID: 18548467.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    34. Solution structure of selenoprotein W and NMR analysis of its interaction with 14-3-3 proteins. J Biol Chem. 2007 Dec 21; 282(51):37036-44. Aachmann FL, Fomenko DE, Soragni A, Gladyshev VN, Dikiy A. PMID: 17928294.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    35. In vitro analysis of protein-operator interactions of the NikR and fur metal-responsive regulators of coregulated genes in Helicobacter pylori. J Bacteriol. 2005 Nov; 187(22):7703-15. Delany I, Ieva R, Soragni A, Hilleringmann M, Rappuoli R, Scarlato V. PMID: 16267295; PMCID: PMC1280292.
      View in: PubMed   Mentions: 46     Fields:    Translation:Cells
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