Ramin Salehi-Rad

Title(s)	HS Assistant Clinical Professor, Medicine
School	Medicine
ORCID	0000-0003-1543-5421
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Overview

Dr. Salehi-Rad is a physician scientist engaged in clinical and translational research in lung cancer. Dr. Salehi-Rad’s research primarily focuses on improving our understanding of the tumor microenvironment and mechanisms through which tumors evade host immune responses. Additionally, Dr. Salehi-Rad’s lab is actively exploring the development of novel gene-modified dendritic cell cancer vaccines as a strategy for overcoming resistance to immunotherapy. As a Pulmonologist, Dr. Salehi-Rad specializes in early detection of lung cancer. He is an active participant in the national consortia in lung cancer, including the NCI Human Tumor Atlas Network (HTAN) and Early Detection Research Network (EDRN) as well as the Stand-Up-To-Cancer (SU2C) Lung Cancer Interception Dream Team.

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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Characteristics of a CCL21-gene modified dendritic cell vaccine utilized for a clinical trial in non-small cell lung cancer. Mol Cancer Ther. 2024 Nov 19. Oh MS, Dumitras C, Salehi-Rad R, Tran LM, Krysan K, Lim RJ, Jing Z, Tappuni S, Lisberg A, Garon EB, Dubinett SM, Liu B. PMID: 39559833.

View in: PubMed Mentions: Fields:
Ant Antineoplastic Agents
Hyper-Interferon Sensitive influenza induces adaptive immune responses and overcomes resistance to anti-PD-1 in murine non-small cell lung cancer. Cancer Immunol Res. 2024 Sep 26. Du Y, Salehi-Rad R, Zhang TH, Crosson WP, Abascal J, Chen D, Shi Y, Jiang H, Tseng YW, Ma X, Hong M, Wang S, Wang X, Tang K, Hu S, Li Y, Ni S, Cai Y, Tappuni S, Shen Y, Liu B, Sun R. PMID: 39325056.

View in: PubMed Mentions: Fields:
All Allergy and Immunology Neo Neoplasms
Premalignant Progression in the Lung: Knowledge Gaps and Novel Opportunities for Interception of Non-Small Cell Lung Cancer. An Official American Thoracic Society Research Statement. Am J Respir Crit Care Med. 2024 Sep 01; 210(5):548-571. Moghaddam SJ, Savai R, Salehi-Rad R, Sengupta S, Kammer MN, Massion P, Beane JE, Ostrin EJ, Priolo C, Tennis MA, Stabile LP, Bauer AK, Sears CR, Szabo E, Rivera MP, Powell CA, Kadara H, Jenkins BJ, Dubinett SM, Houghton AM, Kim CF, Keith RL. PMID: 39115548; PMCID: PMC11389570.

View in: PubMed Mentions: Fields:
Cri Critical Care Pul Pulmonary Medicine
Translation:Humans
CXCL9/10-engineered dendritic cells promote T cell activation and enhance immune checkpoint blockade for lung cancer. Cell Rep Med. 2024 Apr 16; 5(4):101479. Lim RJ, Salehi-Rad R, Tran LM, Oh MS, Dumitras C, Crosson WP, Li R, Patel TS, Man S, Yean CE, Abascal J, Huang Z, Ong SL, Krysan K, Dubinett SM, Liu B. PMID: 38518770; PMCID: PMC11031384.

View in: PubMed Mentions: 3 Fields:
Med Medicine (General)
Translation:Humans Animals Cells
IgM N-glycosylation correlates with COVID-19 severity and rate of complement deposition. Nat Commun. 2024 Jan 09; 15(1):404. Haslund-Gourley BS, Woloszczuk K, Hou J, Connors J, Cusimano G, Bell M, Taramangalam B, Fourati S, Mege N, Bernui M, Altman MC, Krammer F, van Bakel H, IMPACC Network, Maecker HT, Rouphael N, Diray-Arce J, Wigdahl B, Kutzler MA, Cairns CB, Haddad EK, Comunale MA. PMID: 38195739; PMCID: PMC10776791.

View in: PubMed Mentions: 5 Fields:
Bio Biology Sci Science
Translation:Humans Cells
Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study. Nat Commun. 2024 Jan 03; 15(1):216. Ozonoff A, Jayavelu ND, Liu S, Melamed E, Milliren CE, Qi J, Geng LN, McComsey GA, Cairns CB, Baden LR, Schaenman J, Shaw AC, Samaha H, Seyfert-Margolis V, Krammer F, Rosen LB, Steen H, Syphurs C, Dandekar R, Shannon CP, Sekaly RP, Ehrlich LIR, Corry DB, Kheradmand F, Atkinson MA, Brakenridge SC, Higuita NIA, Metcalf JP, Hough CL, Messer WB, Pulendran B, Nadeau KC, Davis MM, Sesma AF, Simon V, van Bakel H, Kim-Schulze S, Hafler DA, Levy O, Kraft M, Bime C, Haddad EK, Calfee CS, Erle DJ, Langelier CR, Eckalbar W, Bosinger SE, IMPACC Network, Peters B, Kleinstein SH, Reed EF, Augustine AD, Diray-Arce J, Maecker HT, Altman MC, Montgomery RR, Becker PM, Rouphael N. PMID: 38172101; PMCID: PMC10764789.

View in: PubMed Mentions: 12 Fields:
Bio Biology Sci Science
Translation:Humans Cells
Host-Microbe Multi-omic Profiling Identifies a Unique Program of COVID-19 Inflammatory Dysregulation in Solid Organ Transplant Recipients. Res Sq. 2023 Dec 20. Langelier C, Pickering H, Schaenman J, Phan H, Maguire C, Tsitsiklis A, Rouphael N, Higuita N, Atkinson M, Breckenridge S, Fung M, Messer W, IMPACC Network, Salehi-Rad R, Altman M, Becker P, Bosinger S, Eckalbar W, Hoch A, Jayavelu N, Kim-Schulze S, Jenkins M, Kleinstein S, Krammer F, Maecker H, Ozonoff A, Diray-Arce J, Shaw A, Baden L, Levy O, Reed E. PMID: 38196658; PMCID: PMC10775393.

View in: PubMed Mentions:
Dendritic Cell Vaccination in Non-Small Cell Lung Cancer: Remodeling the Tumor Immune Microenvironment. Cells. 2023 10 04; 12(19). Abascal J, Oh MS, Liclican EL, Dubinett SM, Salehi-Rad R, Liu B. PMID: 37830618; PMCID: PMC10571973.

View in: PubMed Mentions: 4 Fields:
Bio Biophysics Cel Cell Biology Mol Molecular Biology
Translation:Humans Cells PHPublic Health
Single-Cell Characterization of Pulmonary Nodules Implicates Suppression of Immunosurveillance across Early Stages of Lung Adenocarcinoma. Cancer Res. 2023 10 02; 83(19):3305-3319. Yanagawa J, Tran LM, Salehi-Rad R, Lim RJ, Dumitras C, Fung E, Wallace WD, Prosper AE, Fishbein G, Shea C, Hong R, Kahangi B, Deng JJ, Gower AC, Liu B, Campbell JD, Mazzilli SA, Beane JE, Kadara H, Lenburg ME, Spira AE, Aberle DR, Krysan K, Dubinett SM. PMID: 37477508; PMCID: PMC10544016.

View in: PubMed Mentions: 5 Fields:
Neo Neoplasms
Translation:Humans
CCL21-DC in situ vaccination in murine NSCLC overcomes resistance to immunotherapy and generates systemic tumor-specific immunity. J Immunother Cancer. 2023 09; 11(9). Salehi-Rad R, Lim RJ, Du Y, Tran LM, Li R, Ong SL, Ling Huang Z, Dumitras C, Zhang T, Park SJ, Crosson W, Kahangi B, Abascal J, Seet C, Oh M, Shabihkhani M, Paul M, Krysan K, Lisberg AE, Garon EB, Liu B, Dubinett SM. PMID: 37730274; PMCID: PMC10510892.

View in: PubMed Mentions: 2 Fields:
Neo Neoplasms The Therapeutics
Translation:Humans Animals
Eosinophil recovery in hospitalized COVID-19 patients is associated with lower rates of ICU admission and in-hospital mortality: An observational cohort analysis. Respir Med Res. 2023 Nov; 84:101031. Yan PD, Markovic D, Hixson RY, Shover CM, Buhr RG, Salehi-Rad R, LeMaster B, Tashkin DP, Fulcher JA, Barjaktarevic IZ. PMID: 37647739; PMCID: PMC10232929.

View in: PubMed Mentions: 1 Fields:
Pul Pulmonary Medicine
Translation:Humans Cells
Multi-omic longitudinal study reveals immune correlates of clinical course among hospitalized COVID-19 patients. Cell Rep Med. 2023 06 20; 4(6):101079. Diray-Arce J, Fourati S, Doni Jayavelu N, Patel R, Maguire C, Chang AC, Dandekar R, Qi J, Lee BH, van Zalm P, Schroeder A, Chen E, Konstorum A, Brito A, Gygi JP, Kho A, Chen J, Pawar S, Gonzalez-Reiche AS, Hoch A, Milliren CE, Overton JA, Westendorf K, IMPACC Network, Cairns CB, Rouphael N, Bosinger SE, Kim-Schulze S, Krammer F, Rosen L, Grubaugh ND, van Bakel H, Wilson M, Rajan J, Steen H, Eckalbar W, Cotsapas C, Langelier CR, Levy O, Altman MC, Maecker H, Montgomery RR, Haddad EK, Sekaly RP, Esserman D, Ozonoff A, Becker PM, Augustine AD, Guan L, Peters B, Kleinstein SH. PMID: 37327781; PMCID: PMC10203880.

View in: PubMed Mentions: 16 Fields:
Med Medicine (General)
Translation:Humans Cells
Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: Results from the IMPACC study. EBioMedicine. 2022 Sep; 83:104208. Ozonoff A, Schaenman J, Jayavelu ND, Milliren CE, Calfee CS, Cairns CB, Kraft M, Baden LR, Shaw AC, Krammer F, van Bakel H, Esserman DA, Liu S, Sesma AF, Simon V, Hafler DA, Montgomery RR, Kleinstein SH, Levy O, Bime C, Haddad EK, Erle DJ, Pulendran B, Nadeau KC, Davis MM, Hough CL, Messer WB, Higuita NIA, Metcalf JP, Atkinson MA, Brakenridge SC, Corry D, Kheradmand F, Ehrlich LIR, Melamed E, McComsey GA, Sekaly R, Diray-Arce J, Peters B, Augustine AD, Reed EF, Altman MC, Becker PM, Rouphael N, IMPACC study group members. PMID: 35952496; PMCID: PMC9359694.

View in: PubMed Mentions: 29 Fields:
Gen Genetics Med Medicine (General)
Translation:Humans Cells
Predictors of Invasiveness in Adenocarcinoma of Lung with Lepidic Growth Pattern. Med Sci (Basel). 2022 06 22; 10(3). Young TJ, Salehi-Rad R, Ronaghi R, Yanagawa J, Shahrouki P, Villegas BE, Cone B, Fishbein GA, Wallace WD, Abtin F, Barjaktarevic I. PMID: 35893116; PMCID: PMC9326548.

View in: PubMed Mentions: 2 Fields:
Med Medicine (General)
Translation:Humans
Genotoxic Treatment Enhances Immune Response in a Genetic Model of Lung Cancer. Cancers (Basel). 2021 Jul 18; 13(14). Saggese P, Martinez CA, Tran LM, Lim R, Dumitras C, Grogan T, Elashoff D, Ramin SR, Dubinett SM, Liu B, Scafoglio C. PMID: 34298808; PMCID: PMC8307650.

View in: PubMed Mentions: 1
Inhibition of Granulocytic Myeloid-Derived Suppressor Cells Overcomes Resistance to Immune Checkpoint Inhibition in LKB1-Deficient Non-Small Cell Lung Cancer. Cancer Res. 2021 06 15; 81(12):3295-3308. Li R, Salehi-Rad R, Crosson W, Momcilovic M, Lim RJ, Ong SL, Huang ZL, Zhang T, Abascal J, Dumitras C, Jing Z, Park SJ, Krysan K, Shackelford DB, Tran LM, Liu B, Dubinett SM. PMID: 33853830; PMCID: PMC8776246.

View in: PubMed Mentions: 42 Fields:
Neo Neoplasms
Translation:Humans Animals Cells
Novel Kras-mutant murine models of non-small cell lung cancer possessing co-occurring oncogenic mutations and increased tumor mutational burden. Cancer Immunol Immunother. 2021 Aug; 70(8):2389-2400. Salehi-Rad R, Li R, Tran LM, Lim RJ, Abascal J, Momcilovic M, Park SJ, Ong SL, Shabihkhani M, Huang ZL, Paul M, Shackelford DB, Krysan K, Liu B, Dubinett SM. PMID: 33507343; PMCID: PMC8289771.

View in: PubMed Mentions: 10 Fields:
All Allergy and Immunology Neo Neoplasms The Therapeutics
Translation:Animals Cells
Occult Colonic Perforation in a Patient With Coronavirus Disease 2019 After Interleukin-6 Receptor Antagonist Therapy. Open Forum Infect Dis. 2020 Nov; 7(11):ofaa424. Schwab K, Hamidi S, Chung A, Lim RJ, Khanlou N, Hoesterey D, Dumitras C, Adeyiga OB, Phan-Tang M, Wang TS, Saggar R, Goldstein J, Belperio JA, Dubinett SM, Kim JT, Salehi-Rad R. PMID: 33204749; PMCID: PMC7543619.

View in: PubMed Mentions: 4
The Biology of Lung Cancer: Development of More Effective Methods for Prevention, Diagnosis, and Treatment. Clin Chest Med. 2020 03; 41(1):25-38. Salehi-Rad R, Li R, Paul MK, Dubinett SM, Liu B. PMID: 32008627.

View in: PubMed Mentions: 33 Fields:
Pul Pulmonary Medicine
Translation:Humans
Chronic IL-1β-induced inflammation regulates epithelial-to-mesenchymal transition memory phenotypes via epigenetic modifications in non-small cell lung cancer. Sci Rep. 2020 01 15; 10(1):377. Li R, Ong SL, Tran LM, Jing Z, Liu B, Park SJ, Huang ZL, Walser TC, Heinrich EL, Lee G, Salehi-Rad R, Crosson WP, Pagano PC, Paul MK, Xu S, Herschman H, Krysan K, Dubinett S. PMID: 31941995; PMCID: PMC6962381.

View in: PubMed Mentions: 43 Fields:
Sci Science
Translation:Humans Cells
The Immune Contexture Associates with the Genomic Landscape in Lung Adenomatous Premalignancy. Cancer Res. 2019 Oct 01; 79(19):5022-5033. Krysan K, Tran LM, Grimes BS, Fishbein GA, Seki A, Gardner BK, Walser TC, Salehi-Rad R, Yanagawa J, Lee JM, Sharma S, Aberle DR, Spira AE, Elashoff DA, Wallace WD, Fishbein MC, Dubinett SM. PMID: 31142513; PMCID: PMC6774823.

View in: PubMed Mentions: 30 Fields:
Neo Neoplasms
Translation:Humans
Understanding the mechanisms of immune-evasion by lung cancer in the context of chronic inflammation in emphysema. J Thorac Dis. 2019 Feb; 11(2):382-385. Salehi-Rad R, Dubinett SM. PMID: 30962980; PMCID: PMC6409254.

View in: PubMed Mentions: 3
Understanding the Hurdles in Lung Cancer Immunotherapy in the Context of Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2018 10 01; 198(7):835-837. Salehi-Rad R, Dubinett SM. PMID: 29589957.

View in: PubMed Mentions: Fields:
Cri Critical Care Pul Pulmonary Medicine
Translation:Humans Cells
Treating the Intestine with Oral ApoA-I Mimetic Tg6F Reduces Tumor Burden in Mouse Models of Metastatic Lung Cancer. Sci Rep. 2018 06 13; 8(1):9032. Chattopadhyay A, Yang X, Mukherjee P, Sulaiman D, Fogelman HR, Grijalva V, Dubinett S, Wasler TC, Paul MK, Salehi-Rad R, Mack JJ, Iruela-Arispe ML, Navab M, Fogelman AM, Reddy ST. PMID: 29899427; PMCID: PMC5998131.

View in: PubMed Mentions: 20 Fields:
Sci Science
Translation:Animals Cells
Phase I Trial of Intratumoral Injection of CCL21 Gene-Modified Dendritic Cells in Lung Cancer Elicits Tumor-Specific Immune Responses and CD8+ T-cell Infiltration. Clin Cancer Res. 2017 Aug 15; 23(16):4556-4568. Lee JM, Lee MH, Garon E, Goldman JW, Salehi-Rad R, Baratelli FE, Schaue D, Wang G, Rosen F, Yanagawa J, Walser TC, Lin Y, Park SJ, Adams S, Marincola FM, Tumeh PC, Abtin F, Suh R, Reckamp KL, Lee G, Wallace WD, Lee S, Zeng G, Elashoff DA, Sharma S, Dubinett SM. PMID: 28468947; PMCID: PMC5599263.

View in: PubMed Mentions: 109 Fields:
Neo Neoplasms
Translation:Humans Cells CTClinical Trials
Dipyrone approach toward the synthesis of the cytotoxic natural product auripyrone A. Tetrahedron letters. 2010; 38(51):4931-4933. Jung ME, Salehi-Rad R. View Publication.
Total synthesis of auripyrone B using a non-aldol aldol-cuprate opening process. Org Lett. 2010 Jun 18; 12(12):2872-5. Jung ME, Chaumontet M, Salehi-Rad R. PMID: 20499854; PMCID: PMC4099051.

View in: PubMed Mentions: 4 Fields:
Bio Biochemistry
Translation:Cells
Total synthesis of auripyrone A using a tandem non-aldol aldol/Paterson aldol process as a key step. Angew Chem Int Ed Engl. 2009; 48(46):8766-9. Jung ME, Salehi-Rad R. PMID: 19824033; PMCID: PMC3523744.

View in: PubMed Mentions: 7 Fields:
Che Chemistry
Translation:Cells