Jing Huang

Title(s)Professor, Molecular and Medical Pharmacology
SchoolMedicine
Emailjinghuang@mednet.ucla.edu
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    Collapse Research 
    Collapse Research Activities and Funding
    Identifying molecular targets and biological signatures of CAM natural products
    NIH R01AT006889Aug 1, 2011 - Jun 30, 2018
    Role: Co-Principal Investigator
    A Novel Method for Identifying the Molecular Targets of Bioactive Food Components
    NIH R21CA149774Feb 3, 2010 - Jan 31, 2013
    Role: Principal Investigator
    Exploiting TOR Signaling for Cancer Drug Discovery
    NIH R01CA124974May 1, 2007 - Feb 28, 2013
    Role: Principal Investigator
    A Mixed-Bait-Strategy for Protein Interactome Mapping
    NIH R21HG003729Sep 1, 2006 - Aug 31, 2009
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Stimulation of Hair Growth by Small Molecules that Activate Autophagy. Cell Rep. 2019 06 18; 27(12):3413-3421.e3. Chai M, Jiang M, Vergnes L, Fu X, de Barros SC, Doan NB, Huang W, Chu J, Jiao J, Herschman H, Crooks GM, Reue K, Huang J. PMID: 31216464.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    2. α-Ketoglutarate Accelerates the Initial Differentiation of Primed Human Pluripotent Stem Cells. Cell Metab. 2016 09 13; 24(3):485-493. TeSlaa T, Chaikovsky AC, Lipchina I, Escobar SL, Hochedlinger K, Huang J, Graeber TG, Braas D, Teitell MA. PMID: 27476976; PMCID: PMC5023506.
      View in: PubMed   Mentions: 136     Fields:    Translation:HumansCells
    3. 2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling. Cell Metab. 2015 Sep 01; 22(3):508-15. Fu X, Chin RM, Vergnes L, Hwang H, Deng G, Xing Y, Pai MY, Li S, Ta L, Fazlollahi F, Chen C, Prins RM, Teitell MA, Nathanson DA, Lai A, Faull KF, Jiang M, Clarke SG, Cloughesy TF, Graeber TG, Braas D, Christofk HR, Jung ME, Reue K, Huang J. PMID: 26190651; PMCID: PMC4663076.
      View in: PubMed   Mentions: 124     Fields:    Translation:HumansAnimalsCells
    4. Identification and characterization of β-sitosterol target proteins. Bioorg Med Chem Lett. 2015 Nov 01; 25(21):4976-4979. Lomenick B, Shi H, Huang J, Chen C. PMID: 25804720; PMCID: PMC4567552.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    5. Drug affinity responsive target stability (DARTS) for small-molecule target identification. Methods Mol Biol. 2015; 1263:287-98. Pai MY, Lomenick B, Hwang H, Schiestl R, McBride W, Loo JA, Huang J. PMID: 25618353; PMCID: PMC4442491.
      View in: PubMed   Mentions: 101     Fields:    Translation:Cells
    6. The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature. 2014 Jun 19; 510(7505):397-401. Chin RM, Fu X, Pai MY, Vergnes L, Hwang H, Deng G, Diep S, Lomenick B, Meli VS, Monsalve GC, Hu E, Whelan SA, Wang JX, Jung G, Solis GM, Fazlollahi F, Kaweeteerawat C, Quach A, Nili M, Krall AS, Godwin HA, Chang HR, Faull KF, Guo F, Jiang M, Trauger SA, Saghatelian A, Braas D, Christofk HR, Clarke CF, Teitell MA, Petrascheck M, Reue K, Jung ME, Frand AR, Huang J. PMID: 24828042; PMCID: PMC4263271.
      View in: PubMed   Mentions: 268     Fields:    Translation:HumansAnimalsCells
    7. Tracking drugs. N Engl J Med. 2013 Sep 19; 369(12):1168-9. Huang J. PMID: 24047067.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    8. High-throughput screen identifies disulfiram as a potential therapeutic for triple-negative breast cancer cells: interaction with IQ motif-containing factors. Cell Cycle. 2013 Sep 15; 12(18):3013-24. Robinson TJ, Pai M, Liu JC, Vizeacoumar F, Sun T, Egan SE, Datti A, Huang J, Zacksenhaus E. PMID: 23974104; PMCID: PMC3875676.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    9. The Chemistry and Biology of Nakiterpiosin - C-nor-D-Homosteroids. Synlett. 2012 Oct; 16(23):2298-2310. Gao S, Wang Q, Wang G, Lomenick B, Liu J, Fan CW, Deng LW, Huang J, Lum L, Chen C. PMID: 23226922; PMCID: PMC3515072.
      View in: PubMed   Mentions: 4  
    10. Target identification using drug affinity responsive target stability (DARTS). Curr Protoc Chem Biol. 2011 Dec 01; 3(4):163-180. Lomenick B, Jung G, Wohlschlegel JA, Huang J. PMID: 22229126; PMCID: PMC3251962.
      View in: PubMed   Mentions: 77     Fields:    
    11. A molecular screening approach to identify and characterize inhibitors of glioblastoma stem cells. Mol Cancer Ther. 2011 Oct; 10(10):1818-28. Visnyei K, Onodera H, Damoiseaux R, Saigusa K, Petrosyan S, De Vries D, Ferrari D, Saxe J, Panosyan EH, Masterman-Smith M, Mottahedeh J, Bradley KA, Huang J, Sabatti C, Nakano I, Kornblum HI. PMID: 21859839; PMCID: PMC3191241.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    12. mTOR signaling, function, novel inhibitors, and therapeutic targets. J Nucl Med. 2011 Apr; 52(4):497-500. Watanabe R, Wei L, Huang J. PMID: 21421716.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansCells
    13. Identification of direct protein targets of small molecules. ACS Chem Biol. 2011 Jan 21; 6(1):34-46. Lomenick B, Olsen RW, Huang J. PMID: 21077692; PMCID: PMC3031183.
      View in: PubMed   Mentions: 97     Fields:    Translation:Cells
    14. Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase. Nat Biotechnol. 2010 Jul; 28(7):738-42. Aghajan M, Jonai N, Flick K, Fu F, Luo M, Cai X, Ouni I, Pierce N, Tang X, Lomenick B, Damoiseaux R, Hao R, Del Moral PM, Verma R, Li Y, Li C, Houk KN, Jung ME, Zheng N, Huang L, Deshaies RJ, Kaiser P, Huang J. PMID: 20581845; PMCID: PMC2902569.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansCells
    15. Target identification using drug affinity responsive target stability (DARTS). Proc Natl Acad Sci U S A. 2009 Dec 22; 106(51):21984-9. Lomenick B, Hao R, Jonai N, Chin RM, Aghajan M, Warburton S, Wang J, Wu RP, Gomez F, Loo JA, Wohlschlegel JA, Vondriska TM, Pelletier J, Herschman HR, Clardy J, Clarke CF, Huang J. PMID: 19995983; PMCID: PMC2789755.
      View in: PubMed   Mentions: 329     Fields:    Translation:Cells
    16. Post-translational regulation of Oct4 transcriptional activity. PLoS One. 2009; 4(2):e4467. Saxe JP, Tomilin A, Schöler HR, Plath K, Huang J. PMID: 19221599; PMCID: PMC2637973.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    17. Protein kinase substrate identification on functional protein arrays. BMC Biotechnol. 2008 Feb 28; 8:22. Meng L, Michaud GA, Merkel JS, Zhou F, Huang J, Mattoon DR, Schweitzer B. PMID: 18307815; PMCID: PMC2270825.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    18. A phenotypic small-molecule screen identifies an orphan ligand-receptor pair that regulates neural stem cell differentiation. Chem Biol. 2007 Sep; 14(9):1019-30. Saxe JP, Wu H, Kelly TK, Phelps ME, Sun YE, Kornblum HI, Huang J. PMID: 17884634; PMCID: PMC2758915.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    19. Amiodarone and bepridil inhibit anthrax toxin entry into host cells. Antimicrob Agents Chemother. 2007 Jul; 51(7):2403-11. Sanchez AM, Thomas D, Gillespie EJ, Damoiseaux R, Rogers J, Saxe JP, Huang J, Manchester M, Bradley KA. PMID: 17485504; PMCID: PMC1913235.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    20. A yeast two-hybrid smart-pool-array system for protein-interaction mapping. Nat Methods. 2007 May; 4(5):405-7. Jin F, Avramova L, Huang J, Hazbun T. PMID: 17450148; PMCID: PMC2771206.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    21. Composite synthetic lethal identification of membrane traffic inhibitors. Proc Natl Acad Sci U S A. 2007 Apr 10; 104(15):6235-40. Duncan MC, Ho DG, Huang J, Jung ME, Payne GS. PMID: 17404221; PMCID: PMC1851079.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    22. Cell-based chemical genetic screen identifies damnacanthal as an inhibitor of HIV-1 Vpr induced cell death. Biochem Biophys Res Commun. 2006 Sep 29; 348(3):1101-6. Kamata M, Wu RP, An DS, Saxe JP, Damoiseaux R, Phelps ME, Huang J, Chen IS. PMID: 16904642; PMCID: PMC1761125.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    23. A pooling-deconvolution strategy for biological network elucidation. Nat Methods. 2006 Mar; 3(3):183-9. Jin F, Hazbun T, Michaud GA, Salcius M, Predki PF, Fields S, Huang J. PMID: 16489335; PMCID: PMC2803036.
      View in: PubMed   Mentions: 8     Fields:    
    24. Insights into TOR function and rapamycin response: chemical genomic profiling by using a high-density cell array method. Proc Natl Acad Sci U S A. 2005 May 17; 102(20):7215-20. Xie MW, Jin F, Hwang H, Hwang S, Anand V, Duncan MC, Huang J. PMID: 15883373; PMCID: PMC1091748.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    25. Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips. Proc Natl Acad Sci U S A. 2004 Nov 23; 101(47):16594-9. Huang J, Zhu H, Haggarty SJ, Spring DR, Hwang H, Jin F, Snyder M, Schreiber SL. PMID: 15539461; PMCID: PMC527135.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    26. Molecular imaging of drug-modulated protein-protein interactions in living subjects. Cancer Res. 2004 Mar 15; 64(6):2113-9. Paulmurugan R, Massoud TF, Huang J, Gambhir SS. PMID: 15026351; PMCID: PMC4154786.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    27. Novel functions of the phosphatidylinositol metabolic pathway discovered by a chemical genomics screen with wortmannin. Proc Natl Acad Sci U S A. 2003 Mar 18; 100(6):3345-50. Zewail A, Xie MW, Xing Y, Lin L, Zhang PF, Zou W, Saxe JP, Huang J. PMID: 12615994; PMCID: PMC152295.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    28. Intramolecular regulation of MyoD activation domain conformation and function. Mol Cell Biol. 1998 Sep; 18(9):5478-84. Huang J, Weintraub H, Kedes L. PMID: 9710631; PMCID: PMC109132.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    29. A yeast genetic system for selecting small molecule inhibitors of protein-protein interactions in nanodroplets. Proc Natl Acad Sci U S A. 1997 Dec 09; 94(25):13396-401. Huang J, Schreiber SL. PMID: 9391035; PMCID: PMC28315.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    30. Molecular mechanisms of myogenic coactivation by p300: direct interaction with the activation domain of MyoD and with the MADS box of MEF2C. Mol Cell Biol. 1997 Feb; 17(2):1010-26. Sartorelli V, Huang J, Hamamori Y, Kedes L. PMID: 9001254; PMCID: PMC231826.
      View in: PubMed   Mentions: 127     Fields:    Translation:HumansAnimalsCells
    31. Differences between MyoD DNA binding and activation site requirements revealed by functional random sequence selection. Mol Cell Biol. 1996 Jul; 16(7):3893-900. Huang J, Blackwell TK, Kedes L, Weintraub H. PMID: 8668207; PMCID: PMC231386.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    32. Binding of myc proteins to canonical and noncanonical DNA sequences. Mol Cell Biol. 1993 Sep; 13(9):5216-24. Blackwell TK, Huang J, Ma A, Kretzner L, Alt FW, Eisenman RN, Weintraub H. PMID: 8395000; PMCID: PMC360210.
      View in: PubMed   Mentions: 148     Fields:    Translation:AnimalsCells
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