Alexander Hoffmann

Title(s)Professor, MIMG
SchoolMedicine
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    Collapse Biography 
    Collapse Education and Training
    Cambridge University, Cambridge, EnglandBA06/1988Physics
    Rockefeller University, New York, NYPhD06/1994Biochemistry
    Massachusetts Institute of Technology, Cambridge, MApostdoc01/1998HIV, control of latency
    California Institute of Technology, Pasadena, CApostdoc05/2003NFkB, Systems Immunology

    Collapse Overview 
    Collapse Overview
    The Hoffmann laboratory focuses on the signaling systems that control innate and adaptive immunity. A central theme is that signaling network dynamics determine biological specificity. We have contributed to an understanding of how NFκB and IRF signaling dynamics are regulated, how these are altered during cell differentiation and in human disease contexts, and how rational drug targeting strategies may be applied to correct misregulation. A wide range of experimental work in animals and cell culture, at single-molecule to genome-wide scales, is coordinated with computational modeling. The laboratory currently has three biological foci: 1) macrophages: how their functions are regulated in a stimulus-specific and context-dependent manner, and how prior history of exposure may be harnessed for innate immune training; 2) B-cells: how the intra-cellular molecular regulatory networks control fate decisions of cell death and cell division, and how inter-cellular networks in the germinal center generate the antibody repertoire in response to vaccination; 3) hematopoiesis: how signaling pathways inside and between cells regulate population dynamics via cell fate decisions of cell division, cell death, and differentiation.

    Collapse Research 
    Collapse Research Activities and Funding
    Bruins in Genomics: Dental, Oral & Craniofacial Research Training Program (BIG DOC)
    NIH R25DE030117Jan 15, 2021 - Dec 31, 2025
    Role: Co-Principal Investigator
    The NFkB System in Dendritic Cells
    NIH R01AI127867Apr 3, 2018 - Mar 31, 2023
    Role: Principal Investigator
    Cell decision underlying B-cell immune responses
    NIH R01AI132731Feb 1, 2018 - Jan 31, 2023
    Role: Principal Investigator
    Coordinated dynamic regulation and function of IRF transcription factors
    NIH R01AI132835Jun 20, 2017 - May 31, 2022
    Role: Principal Investigator
    Roles of RelB in tuning inflammatory and innate immune responses
    NIH R21AI128646Dec 19, 2016 - Nov 30, 2019
    Role: Principal Investigator
    NFkB Signaling in Macrophages
    NIH R01AI127864Nov 17, 2016 - Oct 31, 2021
    Role: Principal Investigator
    Understanding dynamical coding by NFkB
    NIH R01GM117134Feb 15, 2016 - Jan 31, 2021
    Role: Principal Investigator
    NGS Data Analysis Skills for the Biosciences Pipeline
    NIH R25EB022364Sep 30, 2015 - Jun 30, 2019
    Role: Principal Investigator
    Ribonomics of Gene Regulation to predict Innate Immune Responses
    NIH U01HG007912Jan 5, 2015 - Nov 30, 2018
    Role: Principal Investigator
    Epigenomic control of RNA splicing
    NIH R01ES024995Sep 5, 2014 - Aug 31, 2017
    Role: Co-Principal Investigator
    San Diego Center for Systems Biology: From Maps to Models
    NIH P50GM085764Sep 18, 2010 - May 31, 2019
    Role: Co-Principal Investigator
    Delays and variability in single-cell NFkB signaling
    NIH R01GM089976May 1, 2010 - Apr 30, 2015
    Role: Co-Principal Investigator
    The NF-kB signaling system as a regulator of B-cell activation
    NIH R01AI083453Dec 15, 2009 - Nov 30, 2014
    Role: Principal Investigator
    IKK:Biophysical basis of dynamic regulation
    NIH R01CA141722Jul 1, 2009 - May 31, 2015
    Role: Co-Principal Investigator
    NFkB during TLR signaling in macrophages
    NIH R01GM071573Jul 1, 2004 - Apr 30, 2014
    Role: Principal Investigator
    Graduate Training Program in Bioinformatics
    NIH T32GM008806Jul 1, 2001 - Jun 30, 2021
    Role: Co-Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Virtually the Same? Evaluating the Effectiveness of Remote Undergraduate Research Experiences. CBE Life Sci Educ. 2023 06; 22(2):ar25. Hess RA, Erickson OA, Cole RB, Isaacs JM, Alvarez-Clare S, Arnold J, Augustus-Wallace A, Ayoob JC, Berkowitz A, Branchaw J, Burgio KR, Cannon CH, Ceballos RM, Cohen CS, Coller H, Disney J, Doze VA, Eggers MJ, Ferguson EL, Gray JJ, Greenberg JT, Hoffmann A, Jensen-Ryan D, Kao RM, Keene AC, Kowalko JE, Lopez SA, Mathis C, Minkara M, Murren CJ, Ondrechen MJ, Ordo?ez P, Osano A, Padilla-Crespo E, Palchoudhury S, Qin H, Ram?rez-Lugo J, Reithel J, Shaw CA, Smith A, Smith RJ, Tsien F, Dolan EL. PMID: 37058442.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    2. Tonic TNF conditioning of macrophages safeguards stimulus-specific inflammatory responses. EMBO Rep. 2023 May 22; e55986. Luecke S, Adelaja A, Guo X, Sen S, Spreafico R, Singh A, Liu Y, Taylor B, Diaz J, Cheng Q, Hoffmann A. PMID: 37212045.
      View in: PubMed   Mentions:    Fields:    
    3. The bridge towards a more stable and active side-on-peroxido (Cu2II(µ-η2:η2-O2)) complex as a tyrosinase model system. Faraday Discuss. 2023 May 03. Dalhoff R, Schmidt R, Steeb L, Rabatinova K, Witte M, Teeuwen S, Benjamaâ S, Hüppe H, Hoffmann A, Herres-Pawlis S. PMID: 37132380.
      View in: PubMed   Mentions:    Fields:    
    4. A Multitool for Circular Economy - Fast Ring-Opening Polymerization and Chemical Recycling of (Bio)polyesters Using a Single Aliphatic Guanidine Carboxy Zinc Catalyst. ChemSusChem. 2023 Apr 11; e202300192. Fuchs M, Sch?fer PM, Wagner W, Krumm I, Walbeck M, Dietrich R, Hoffmann A, Herres-Pawlis S. PMID: 37041114.
      View in: PubMed   Mentions:    Fields:    
    5. A stimulus-contingent positive feedback loop enables IFN-� dose-dependent activation of pro-inflammatory genes. Mol Syst Biol. 2023 Mar 17; e11294. Wilder CL, Lefaudeux D, Mathenge R, Kishimoto K, Zuniga Munoz A, Nguyen MA, Meyer AS, Cheng QJ, Hoffmann A. PMID: 36929731.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    6. The NF-?B multidimer system model: A knowledge base to explore diverse biological contexts. Sci Signal. 2023 03 14; 16(776):eabo2838. Mitchell S, Tsui R, Tan ZC, Pack A, Hoffmann A. PMID: 36917644.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    7. Triflate vs Acetonitrile: Understanding the Iron(II)-Based Coordination Chemistry of Tri(quinolin-8-yl)amine. Inorg Chem. 2023 Mar 20; 62(11):4435-4455. H?ppe HM, Iffland-M?hlhaus L, Heck J, Eilers M, Gildenast H, Sch?nfeld S, D?rrmann A, Hoffmann A, Weber B, Apfel UP, Herres-Pawlis S. PMID: 36888965.
      View in: PubMed   Mentions:    Fields:    
    8. A biochemical necroptosis model explains cell-type-specific responses to cell death cues. Biophys J. 2023 03 07; 122(5):817-834. Ildefonso GV, Oliver Metzig M, Hoffmann A, Harris LA, Lopez CF. PMID: 36710493; PMCID: PMC10027451.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Quantifying stimulus-response specificity to probe the functional state of macrophages. Cell Syst. 2023 03 15; 14(3):180-195.e5. Sheu KM, Guru AA, Hoffmann A. PMID: 36657439; PMCID: PMC10023480.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    10. Open Loop Recycling - Guanidine Iron(II) Polymerization Catalyst for the Depolymerization of Polylactide. Chem Asian J. 2023 Mar 01; 18(5):e202201195. Burkart L, Eith A, Hoffmann A, Herres-Pawlis S. PMID: 36577118.
      View in: PubMed   Mentions:    Fields:    
    11. Comparative analysis of oral and intravenous iron therapy in rat models of inflammatory anemia and iron deficiency. Haematologica. 2023 01 01; 108(1):135-149. De Souza LV, Hoffmann A, Fischer C, Petzer V, Asshoff M, Theurl I, Tymoszuk P, Seifert M, Brigo N, Hilbe R, Demetz E, Von Raffay L, Berger S, Barros-Pinkelnig M, Weiss G. PMID: 35796011; PMCID: PMC9827174.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    12. Kinetics of mRNA nuclear export regulate innate immune response gene expression. Nat Commun. 2022 Nov 23; 13(1):7197. Lefaudeux D, Sen S, Jiang K, Hoffmann A, UCLA Ribonomics Group. PMID: 36424375; PMCID: PMC9691726.
      View in: PubMed   Mentions:    Fields:    
    13. NF?B pathway dysregulation due to reduced RelB expression leads to severe autoimmune disorders and declining immunity. J Autoimmun. 2022 Nov 16; 102946. Sharfe N, Dalal I, Naghdi Z, Lefaudeux D, Vong L, Dadi H, Navarro H, Tasher D, Ovadia A, Zangen T, Ater D, Ngan B, Hoffmann A, Roifman CM. PMID: 36402602.
      View in: PubMed   Mentions:    Fields:    
    14. Availability of Ferritin-Bound Iron to Enterobacteriaceae. Int J Mol Sci. 2022 Oct 28; 23(21). Gehrer CM, Hoffmann A, Hilbe R, Grubwieser P, Mitterstiller AM, Talasz H, Fang FC, Meyron-Holtz EG, Atkinson SH, Weiss G, Nairz M. PMID: 36361875; PMCID: PMC9657528.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    15. TUCAN: A molecular identifier and descriptor applicable to the whole periodic table from hydrogen to oganesson. J Cheminform. 2022 Sep 28; 14(1):66. Brammer JC, Blanke G, Kellner C, Hoffmann A, Herres-Pawlis S, Schatzschneider U. PMID: 36171627; PMCID: PMC9520877.
      View in: PubMed   Mentions: 3  
    16. Formate complexes of tri- and tetravalent titanium supported by a tris(phenolato)amine ligand. Dalton Trans. 2022 Sep 26; 51(37):14345-14351. Okumura A, Ghana P, Fink F, Schmidt R, Hoffmann A, Spaniol TP, Herres-Pawlis S, Okuda J. PMID: 36069600.
      View in: PubMed   Mentions:    Fields:    
    17. Understanding the structure-activity relationship and performance of highly active novel ATRP catalysts. Dalton Trans. 2022 Sep 13; 51(35):13272-13287. Kr?ckert KW, Garg F, Heinz MV, Lange J, Sim?es PP, Schmidt R, Bienemann O, Hoffmann A, Herres-Pawlis S. PMID: 35983714.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    18. Effective Ligand Design: Zinc Complexes with Guanidine Hydroquinoline Ligands for Fast Lactide Polymerization and Chemical Recycling. ChemSusChem. 2022 Sep 20; 15(18):e202201603. Hermann A, Becker T, Sch?fer MA, Hoffmann A, Herres-Pawlis S. PMID: 36048139.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    19. Author Correction: I?Ba is required for full transcriptional induction of some NF?B-regulated genes in response to TNF in MCF-7 cells. NPJ Syst Biol Appl. 2022 Aug 04; 8(1):26. Ando M, Magi S, Seki M, Suzuki Y, Kasukawa T, Lefaudeux D, Hoffmann A, Okada M. PMID: 35927293; PMCID: PMC9352786.
      View in: PubMed   Mentions:    Fields:    
    20. Effective Ligand Design: Zinc Complexes with Guanidine Hydroquinoline Ligands for Fast Lactide Polymerization and Chemical Recycling. ChemSusChem. 2022 Sep 20; 15(18):e202201075. Hermann A, Becker T, Sch?fer MA, Hoffmann A, Herres-Pawlis S. PMID: 35803895.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    21. Quantifying information of intracellular signaling: progress with machine learning. Rep Prog Phys. 2022 07 12; 85(8). Tang Y, Hoffmann A. PMID: 35724636; PMCID: PMC9507437.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    22. Stochastic models of nucleosome dynamics reveal regulatory rules of stimulus-induced epigenome remodeling. Cell Rep. 2022 07 12; 40(2):111076. Kim J, Sheu KM, Cheng QJ, Hoffmann A, Enciso G. PMID: 35830792; PMCID: PMC10074953.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    23. Manipulating electron transfer - the influence of substituents on novel copper guanidine quinolinyl complexes. Chem Sci. 2022 Jul 20; 13(28):8274-8288. Heck J, Metz F, Buchenau S, Teubner M, Grimm-Lebsanft B, Spaniol TP, Hoffmann A, R?bhausen MA, Herres-Pawlis S. PMID: 35919707; PMCID: PMC9297705.
      View in: PubMed   Mentions:
    24. DMT1 Protects Macrophages from Salmonella Infection by Controlling Cellular Iron Turnover and Lipocalin 2 Expression. Int J Mol Sci. 2022 Jun 17; 23(12). Grander M, Hoffmann A, Seifert M, Demetz E, Grubwieser P, Pfeifhofer-Obermair C, Haschka D, Weiss G. PMID: 35743233; PMCID: PMC9223531.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    25. Geometrical benchmarking and analysis of redox potentials of copper(I/II) guanidine-quinoline complexes: Comparison of semi-empirical tight-binding and DFT methods and the challenge of describing the entatic state (part III). J Comput Chem. 2022 May 31. Ra?pe-Lange L, Hoffmann A, Gertig C, Heck J, Leonhard K, Herres-Pawlis S. PMID: 35640228.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    26. Bruins-in-Genomics: Evaluation of the impact of a UCLA undergraduate summer program in computational biology on participating students. PLoS One. 2022; 17(5):e0268861. Coller HA, Beggs S, Andrews S, Maloy J, Chiu A, Sankararaman S, Pellegrini M, Freimer N, Johnson T, Papp J, Eskin E, Hoffmann A. PMID: 35622842; PMCID: PMC9140266.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    27. Airway Epithelial Cells Differentially Adapt Their Iron Metabolism to Infection With Klebsiella pneumoniae and Escherichia coli In Vitro. Front Cell Infect Microbiol. 2022; 12:875543. Grubwieser P, Hoffmann A, Hilbe R, Seifert M, Sonnweber T, B?ck N, Theurl I, Weiss G, Nairz M. PMID: 35663465; PMCID: PMC9157649.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    28. From Antibody Repertoires to Cell-Cell Interactions to Molecular Networks: Bridging Scales in the Germinal Center. Front Immunol. 2022; 13:898078. Vaidehi Narayanan H, Hoffmann A. PMID: 35603162; PMCID: PMC9114758.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    29. Functional Hallmarks of Healthy Macrophage Responses: Their Regulatory Basis and Disease Relevance. Annu Rev Immunol. 2022 04 26; 40:295-321. Sheu KM, Hoffmann A. PMID: 35471841; PMCID: PMC10074967.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    30. Controlling Cancer Cell Death Types to Optimize Anti-Tumor Immunity. Biomedicines. 2022 Apr 22; 10(5). Oliver Metzig M, Hoffmann A. PMID: 35625711; PMCID: PMC9138898.
      View in: PubMed   Mentions:
    31. Guanidine Carboxy Zinc Complexes for the Chemical Recycling of Renewable Polyesters. Chempluschem. 2022 05; 87(5):e202200029. Fuchs M, Walbeck M, Jagla E, Hoffmann A, Herres-Pawlis S. PMID: 35333458.
      View in: PubMed   Mentions: 1  
    32. "How Do We Do This at a Distance?!" A Descriptive Study of Remote Undergraduate Research Programs during COVID-19. CBE Life Sci Educ. 2022 03; 21(1):ar1. Erickson OA, Cole RB, Isaacs JM, Alvarez-Clare S, Arnold J, Augustus-Wallace A, Ayoob JC, Berkowitz A, Branchaw J, Burgio KR, Cannon CH, Ceballos RM, Cohen CS, Coller H, Disney J, Doze VA, Eggers MJ, Farina S, Ferguson EL, Gray JJ, Greenberg JT, Hoffmann A, Jensen-Ryan D, Kao RM, Keene AC, Kowalko JE, Lopez SA, Mathis C, Minkara M, Murren CJ, Ondrechen MJ, Ordoñez P, Osano A, Padilla-Crespo E, Palchoudhury S, Qin H, Ramírez-Lugo J, Reithel J, Shaw CA, Smith A, Smith R, Summers AP, Tsien F, Dolan EL. PMID: 34978923; PMCID: PMC9250374.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCellsPHPublic Health
    33. Pathogenic TNF-α drives peripheral nerve inflammation in an Aire-deficient model of autoimmunity. Proc Natl Acad Sci U S A. 2022 01 25; 119(4). Wang Y, Guo L, Yin X, McCarthy EC, Cheng MI, Hoang AT, Chen HC, Patel AY, Allard Trout D, Xu E, Yakobian N, Hugo W, Howard JF, Sheu KM, Hoffmann A, Lechner MG, Su MA. PMID: 35058362; PMCID: PMC8795502.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    34. Cell-specific expression of Hfe determines the outcome of Salmonella enterica serovar Typhimurium infection in mice Haematologica. 2021 12 01; 106(12):3149-3161. Nairz M, Metzendorf C, Vujic-Spasic M, Mitterstiller AM, Schroll A, Haschka D, Hoffmann A, Von Raffay L, Sparla R, Huck CW, Talasz H, Moser PL, Muckenthaler MU, Weiss G. PMID: 33054105; PMCID: PMC8634192.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    35. IκBα is required for full transcriptional induction of some NFκB-regulated genes in response to TNF in MCF-7 cells. NPJ Syst Biol Appl. 2021 12 01; 7(1):42. Ando M, Magi S, Seki M, Suzuki Y, Kasukawa T, Lefaudeux D, Hoffmann A, Okada M. PMID: 34853340; PMCID: PMC8636565.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    36. Acute and Chronic Changes in Gene Expression After CMV DNAemia in Kidney Transplant Recipients. Front Immunol. 2021; 12:750659. Ahn R, Schaenman J, Qian Z, Pickering H, Groysberg V, Rossetti M, Llamas M, Hoffmann A, Gjertson D, Deng M, Bunnapradist S, Reed EF, CMV Systems Immunobiology Group. PMID: 34867983; PMCID: PMC8634678.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    37. NK and CD8+ T cell phenotypes predict onset and control of CMV viremia after kidney transplant. JCI Insight. 2021 11 08; 6(21). Pickering H, Sen S, Arakawa-Hoyt J, Ishiyama K, Sun Y, Parmar R, Ahn RS, Sunga G, Llamas M, Hoffmann A, Deng M, Bunnapradist S, Schaenman JM, Gjertson DW, Rossetti M, Lanier LL, Reed EF, CMV Systems Immunobiology Group. PMID: 34609965; PMCID: PMC8663544.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    38. Stimulus-specific responses in innate immunity: Multilayered regulatory circuits. Immunity. 2021 09 14; 54(9):1915-1932. Luecke S, Sheu KM, Hoffmann A. PMID: 34525335; PMCID: PMC8452151.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    39. Baseline iron status and presence of anaemia determine the course of systemic Salmonella infection following oral iron supplementation in mice. EBioMedicine. 2021 Sep; 71:103568. Hoffmann A, Haschka D, Valente de Souza L, Tymoszuk P, Seifert M, von Raffay L, Hilbe R, Petzer V, Moser PL, Nairz M, Weiss G. PMID: 34488018; PMCID: PMC8426537.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    40. Active in Sleep: Iron Guanidine Catalyst Performs ROP on Dormant Side of ATRP. Angew Chem Int Ed Engl. 2021 09 27; 60(40):21795-21800. Rittinghaus RD, Karabulut A, Hoffmann A, Herres-Pawlis S. PMID: 34270162; PMCID: PMC8518923.
      View in: PubMed   Mentions: 3     Fields:    
    41. Pharmacological Targeting of BMP6-SMAD Mediated Hepcidin Expression Does Not Improve the Outcome of Systemic Infections With Intra-Or Extracellular Gram-Negative Bacteria in Mice. Front Cell Infect Microbiol. 2021; 11:705087. Hoffmann A, de Souza LV, Seifert M, von Raffay L, Haschka D, Grubwieser P, Grander M, Mitterstiller AM, Nairz M, Poli M, Weiss G. PMID: 34368018; PMCID: PMC8342937.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    42. Influence of the amine donor on hybrid guanidine-stabilized Bis(�-oxido) dicopper(III) complexes and their tyrosinase-like oxygenation activity towards polycyclic aromatic alcohols. J Inorg Biochem. 2021 11; 224:111541. Paul M, Teubner M, Grimm-Lebsanft B, Buchenau S, Hoffmann A, R?bhausen M, Herres-Pawlis S. PMID: 34416481.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    43. Identifying the combinatorial control of signal-dependent transcription factors. PLoS Comput Biol. 2021 06; 17(6):e1009095. Wang N, Lefaudeux D, Mazumder A, Li JJ, Hoffmann A. PMID: 34166361; PMCID: PMC8263068.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    44. NF-κB dynamics determine the stimulus specificity of epigenomic reprogramming in macrophages. Science. 2021 06 18; 372(6548):1349-1353. Cheng QJ, Ohta S, Sheu KM, Spreafico R, Adelaja A, Taylor B, Hoffmann A. PMID: 34140389; PMCID: PMC8489855.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    45. Melanoma dedifferentiation induced by IFN-γ epigenetic remodeling in response to anti-PD-1 therapy. J Clin Invest. 2021 06 15; 131(12). Kim YJ, Sheu KM, Tsoi J, Abril-Rodriguez G, Medina E, Grasso CS, Torrejon DY, Champhekar AS, Litchfield K, Swanton C, Speiser DE, Scumpia PO, Hoffmann A, Graeber TG, Puig-Saus C, Ribas A. PMID: 33914706; PMCID: PMC8203459.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    46. Six distinct NFκB signaling codons convey discrete information to distinguish stimuli and enable appropriate macrophage responses. Immunity. 2021 05 11; 54(5):916-930.e7. Adelaja A, Taylor B, Sheu KM, Liu Y, Luecke S, Hoffmann A. PMID: 33979588; PMCID: PMC8184127.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    47. A new generation of terminal copper nitrenes and their application in aromatic C-H amination reactions. Dalton Trans. 2021 May 21; 50(19):6444-6462. Thomas F, Oster M, Sch?n F, G?bgen KC, Amarouch B, Steden D, Hoffmann A, Herres-Pawlis S. PMID: 33908532.
      View in: PubMed   Mentions:    Fields:    
    48. High Dose IFN-β Activates GAF to Enhance Expression of ISGF3 Target Genes in MLE12 Epithelial Cells. Front Immunol. 2021; 12:651254. Kishimoto K, Wilder CL, Buchanan J, Nguyen M, Okeke C, Hoffmann A, Cheng QJ. PMID: 33897699; PMCID: PMC8062733.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    49. Human DNA methylation signatures differentiate persistent from resolving MRSA bacteremia. Proc Natl Acad Sci U S A. 2021 03 09; 118(10). Chang YL, Rossetti M, Gjertson DW, Rubbi L, Thompson M, Montoya DJ, Morselli M, Ruffin F, Hoffmann A, Pellegrini M, Fowler VG, Yeaman MR, Reed EF, with the MRSA Systems Immunology Group. PMID: 33649198; PMCID: PMC7958259.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    50. Quantifying information accumulation encoded in the dynamics of biochemical signaling. Nat Commun. 2021 02 24; 12(1):1272. Tang Y, Adelaja A, Ye FX, Deeds E, Wollman R, Hoffmann A. PMID: 33627672; PMCID: PMC7904837.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    51. Room temperature stable multitalent: highly reactive and versatile copper guanidine complexes in oxygenation reactions. J Biol Inorg Chem. 2021 05; 26(2-3):249-263. Paul M, Hoffmann A, Herres-Pawlis S. PMID: 33595752; PMCID: PMC8068697.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    52. NF-κB responds to absolute differences in cytokine concentrations. Sci Signal. 2021 01 19; 14(666). Son M, Wang AG, Tu HL, Metzig MO, Patel P, Husain K, Lin J, Murugan A, Hoffmann A, Tay S. PMID: 34211635; PMCID: PMC8244746.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    53. Iron in immune cell function and host defense. Semin Cell Dev Biol. 2021 07; 115:27-36. Haschka D, Hoffmann A, Weiss G. PMID: 33386235.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    54. An incoherent feedforward loop interprets NFκB/RelA dynamics to determine TNF-induced necroptosis decisions. Mol Syst Biol. 2020 12; 16(12):e9677. Oliver Metzig M, Tang Y, Mitchell S, Taylor B, Foreman R, Wollman R, Hoffmann A. PMID: 33314666; PMCID: PMC7734648.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    55. Impact of bacterial infections on erythropoiesis. Expert Rev Anti Infect Ther. 2021 05; 19(5):619-633. Valente de Souza L, Hoffmann A, Weiss G. PMID: 33092423.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    56. Next Generation of Zinc Bisguanidine Polymerization Catalysts towards Highly Crystalline, Biodegradable Polyesters. Angew Chem Int Ed Engl. 2020 11 23; 59(48):21778-21784. Hermann A, Hill S, Metz A, Heck J, Hoffmann A, Hartmann L, Herres-Pawlis S. PMID: 32954634; PMCID: PMC7814670.
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    57. Interplay of Spin Crossover and Coordination-Induced Spin State Switch for Iron Bis(pyrazolyl)methanes in Solution. Inorg Chem. 2020 Oct 19; 59(20):15343-15354. Keisers K, H?ppe HM, Iffland-M?hlhaus L, Hoffmann A, G?bel C, Apfel UP, Weber B, Herres-Pawlis S. PMID: 33002361.
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    58. A fully human anti-BMP6 antibody reduces the need for erythropoietin in rodent models of the anemia of chronic disease. Blood. 2020 08 27; 136(9):1080-1090. Petzer V, Tymoszuk P, Asshoff M, Carvalho J, Papworth J, Deantonio C, Bayliss L, Wake MS, Seifert M, Brigo N, Valente de Souza L, Hilbe R, Grubwieser P, Demetz E, Dichtl S, Volani C, Berger S, B?hm F, Hoffmann A, Pfeifhofer-Obermair C, von Raffay L, Sopper S, Arndt S, Bosserhoff A, Kautz L, Perrier P, Nairz M, Wolf D, Weiss G, Germaschewski V, Theurl I. PMID: 32438400; PMCID: PMC7453149.
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    59. IκBα Nuclear Export Enables 4-1BB-Induced cRel Activation and IL-2 Production to Promote CD8 T Cell Immunity. J Immunol. 2020 09 15; 205(6):1540-1553. Lisiero DN, Cheng Z, Tejera MM, Neldner BT, Warrick JW, Wuerzberger-Davis SM, Hoffmann A, Suresh M, Miyamoto S. PMID: 32817348; PMCID: PMC7484350.
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    60. Enhanced catalytic activity of copper complexes in microgels for aerobic oxidation of benzyl alcohols. Chem Commun (Camb). 2020 May 27; 56(42):5601-5604. Sch?fer D, Fink F, Kleinschmidt D, Keisers K, Thomas F, Hoffmann A, Pich A, Herres-Pawlis S. PMID: 32355940.
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    61. Exceptional Substrate Diversity in Oxygenation Reactions Catalyzed by a Bis(�-oxo) Copper Complex. Chemistry. 2020 Jun 18; 26(34):7556-7562. Paul M, Teubner M, Grimm-Lebsanft B, Golchert C, Meiners Y, Senft L, Keisers K, Liebh?user P, R?sener T, Biebl F, Buchenau S, Naumova M, Murzin V, Krug R, Hoffmann A, Pietruszka J, Ivanovic-Burmazovic I, R?bhausen M, Herres-Pawlis S. PMID: 32104930; PMCID: PMC7317579.
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    62. Dissecting the Regulatory Strategies of NF-κB RelA Target Genes in the Inflammatory Response Reveals Differential Transactivation Logics. Cell Rep. 2020 02 25; 30(8):2758-2775.e6. Ngo KA, Kishimoto K, Davis-Turak J, Pimplaskar A, Cheng Z, Spreafico R, Chen EY, Tam A, Ghosh G, Mitchell S, Hoffmann A. PMID: 32101750; PMCID: PMC7061728.
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    63. Gene Regulatory Strategies that Decode the Duration of NFκB Dynamics Contribute to LPS- versus TNF-Specific Gene Expression. Cell Syst. 2020 02 26; 10(2):169-182.e5. Sen S, Cheng Z, Sheu KM, Chen YH, Hoffmann A. PMID: 31972132; PMCID: PMC7047529.
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    64. Undiscovered Potential: Ge Catalysts for Lactide Polymerization. Chemistry. 2020 Jan 02; 26(1):212-221. Rittinghaus RD, Tremmel J, Ru?icka A, Conrads C, Albrecht P, Hoffmann A, Ksiazkiewicz AN, Pich A, Jambor R, Herres-Pawlis S. PMID: 31587400; PMCID: PMC6972987.
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    65. Stimulus-specificity in the Responses of Immune Sentinel Cells. Curr Opin Syst Biol. 2019 Dec; 18:53-61. Sheu K, Luecke S, Hoffmann A. PMID: 32864512; PMCID: PMC7450653.
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    66. Identifying determinants of persistent MRSA bacteremia using mathematical modeling. PLoS Comput Biol. 2019 07; 15(7):e1007087. Mikkaichi T, Yeaman MR, Hoffmann A, MRSA Systems Immunobiology Group. PMID: 31295255; PMCID: PMC6622483.
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    67. Signaling Crosstalk Mechanisms That May Fine-Tune Pathogen-Responsive NFκB. Front Immunol. 2019; 10:433. Adelaja A, Hoffmann A. PMID: 31312197; PMCID: PMC6614373.
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    68. An NFκB Activity Calculator to Delineate Signaling Crosstalk: Type I and II Interferons Enhance NFκB via Distinct Mechanisms. Front Immunol. 2019; 10:1425. Mitchell S, Mercado EL, Adelaja A, Ho JQ, Cheng QJ, Ghosh G, Hoffmann A. PMID: 31293585; PMCID: PMC6604663.
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    69. Dual oxidase/oxygenase reactivity and resonance Raman spectra of {Cu3O2} moiety with perfluoro-t-butoxide ligands. Dalton Trans. 2019 May 21; 48(20):6899-6909. Brazeau SEN, Norwine EE, Hannigan SF, Orth N, Ivanovic-Burmazovic I, Rukser D, Biebl F, Grimm-Lebsanft B, Praedel G, Teubner M, R?bhausen M, Liebh?user P, R?sener T, Stanek J, Hoffmann A, Herres-Pawlis S, Doerrer LH. PMID: 31038147.
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    70. Tuning a robust system: N,O zinc guanidine catalysts for the ROP of lactide. Dalton Trans. 2019 May 07; 48(18):6071-6082. Sch?fer PM, McKeown P, Fuchs M, Rittinghaus RD, Hermann A, Henkel J, Seidel S, Roitzheim C, Ksiazkiewicz AN, Hoffmann A, Pich A, Jones MD, Herres-Pawlis S. PMID: 30758389.
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    71. Substrate complex competition is a regulatory motif that allows NFκB RelA to license but not amplify NFκB RelB. Proc Natl Acad Sci U S A. 2019 05 21; 116(21):10592-10597. Mitchell S, Hoffmann A. PMID: 31048505; PMCID: PMC6535030.
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    72. Sequential conditioning-stimulation reveals distinct gene- and stimulus-specific effects of Type I and II IFN on human macrophage functions. Sci Rep. 2019 03 27; 9(1):5288. Cheng Q, Behzadi F, Sen S, Ohta S, Spreafico R, Teles R, Modlin RL, Hoffmann A. PMID: 30918279; PMCID: PMC6437173.
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    73. New Kids in Lactide Polymerization: Highly Active and Robust Iron Guanidine Complexes as Superior Catalysts. ChemSusChem. 2019 May 21; 12(10):2161-2165. Rittinghaus RD, Sch?fer PM, Albrecht P, Conrads C, Hoffmann A, Ksiazkiewicz AN, Bienemann O, Pich A, Herres-Pawlis S. PMID: 30811863.
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    74. A Regulatory Circuit Controlling the Dynamics of NFκB cRel Transitions B Cells from Proliferation to Plasma Cell Differentiation. Immunity. 2019 03 19; 50(3):616-628.e6. Roy K, Mitchell S, Liu Y, Ohta S, Lin YS, Metzig MO, Nutt SL, Hoffmann A. PMID: 30850343; PMCID: PMC6955201.
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    75. Mathematical modeling identifies potential gene structure determinants of co-transcriptional control of alternative pre-mRNA splicing. Nucleic Acids Res. 2019 Feb 20; 47(3):1602-1603. Davis-Turak J, Johnson TL, Hoffmann A. PMID: 30649426; PMCID: PMC6379712.
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    76. Dopamine Is a Siderophore-Like Iron Chelator That Promotes Salmonella enterica Serovar Typhimurium Virulence in Mice. mBio. 2019 02 05; 10(1). Dichtl S, Demetz E, Haschka D, Tymoszuk P, Petzer V, Nairz M, Seifert M, Hoffmann A, Brigo N, Würzner R, Theurl I, Karlinsey JE, Fang FC, Weiss G. PMID: 30723125; PMCID: PMC6428752.
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    77. Mathematical modeling identifies potential gene structure determinants of co-transcriptional control of alternative pre-mRNA splicing. Nucleic Acids Res. 2018 11 16; 46(20):10598-10607. Davis-Turak J, Johnson TL, Hoffmann A. PMID: 30272246; PMCID: PMC6237756.
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    78. Polypyrimidine tract-binding protein blocks miRNA-124 biogenesis to enforce its neuronal-specific expression in the mouse. Proc Natl Acad Sci U S A. 2018 11 20; 115(47):E11061-E11070. Yeom KH, Mitchell S, Linares AJ, Zheng S, Lin CH, Wang XJ, Hoffmann A, Black DL. PMID: 30401736; PMCID: PMC6255174.
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    79. Designed To React: Terminal Copper Nitrenes and Their Application in Catalytic C-H Aminations. Angew Chem Int Ed Engl. 2018 Jul 16; 57(29):9154-9159. Moegling J, Hoffmann A, Thomas F, Orth N, Liebh?user P, Herber U, Rampmaier R, Stanek J, Fink G, Ivanovic-Burmazovic I, Herres-Pawlis S. PMID: 29734490.
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    80. Nongenetic origins of cell-to-cell variability in B lymphocyte proliferation. Proc Natl Acad Sci U S A. 2018 03 20; 115(12):E2888-E2897. Mitchell S, Roy K, Zangle TA, Hoffmann A. PMID: 29514960; PMCID: PMC5866559.
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    81. Rational Syntheses and Serendipity: Complexes [LSnPtCl2 (SMe2 )]2 , [{LSnPtCl(SMe2 )}2 SnCl2 ], [(LSn)3 (PtCl2 )(PtClSnCl){LSn(Cl)OH}], and [O(SnCl)2 (SnL)2 ] with L=MeN(CH2 CMe2 O)2. Chemistry. 2018 Apr 11; 24(21):5551-5561. Z?ller T, Dietz C, Winter F, P?ttgen R, Gorelsky SI, Hoffmann A, Herres-Pawlis S, Jurkschat K. PMID: 29383765.
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    82. Deriving Quantitative Cell Biological Information from Dye-Dilution Lymphocyte Proliferation Experiments. Methods Mol Biol. 2018; 1707:81-94. Roy K, Shokhirev MN, Mitchell S, Hoffmann A. PMID: 29388101; PMCID: PMC8363314.
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    83. Identifying Noise Sources governing cell-to-cell variability. Curr Opin Syst Biol. 2018 Apr; 8:39-45. Mitchell S, Hoffmann A. PMID: 29623300; PMCID: PMC5879788.
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    84. Corrigendum: Highly Active N,O Zinc Guanidine Catalysts for the Ring-Opening Polymerization of Lactide. ChemSusChem. 2017 12 08; 10(23):4799. Sch?fer PM, Fuchs M, Ohligschl?ger A, Rittinghaus R, McKeown P, Akin E, Schmidt M, Hoffmann A, Liauw MA, Jones MD, Herres-Pawlis S. PMID: 29218842.
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    85. Copper Guanidinoquinoline Complexes as Entatic State Models of Electron-Transfer Proteins. Chemistry. 2017 Nov 07; 23(62):15738-15745. Stanek J, Sackers N, Fink F, Paul M, Peters L, Grunzke R, Hoffmann A, Herres-Pawlis S. PMID: 28850743.
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    86. Highly Active N,O Zinc Guanidine Catalysts for the Ring-Opening Polymerization of Lactide. ChemSusChem. 2017 09 22; 10(18):3547-3556. Sch?fer PM, Fuchs M, Ohligschl?ger A, Rittinghaus R, McKeown P, Akin E, Schmidt M, Hoffmann A, Liauw MA, Jones MD, Herres-Pawlis S. PMID: 28779508.
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    87. Addressing the Digital Divide in Contemporary Biology: Lessons from Teaching UNIX. Trends Biotechnol. 2017 10; 35(10):901-903. Mangul S, Martin LS, Hoffmann A, Pellegrini M, Eskin E. PMID: 28720283.
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    88. Record Broken: A Copper Peroxide Complex with Enhanced Stability and Faster Hydroxylation Catalysis. Chemistry. 2017 Sep 07; 23(50):12171-12183. Liebh?user P, Keisers K, Hoffmann A, Schnappinger T, Sommer I, Thoma A, Wilfer C, Schoch R, St?hrenberg K, Bauer M, D?rr M, Ivanovic-Burmazovic I, Herres-Pawlis S. PMID: 28425134.
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    89. On the Way to a Trisanionic {Cu3 O2 } Core for Oxidase Catalysis: Evidence of an Asymmetric Trinuclear Precursor Stabilized by Perfluoropinacolate Ligands. Chemistry. 2017 Jun 16; 23(34):8212-8224. Hannigan SF, Arnoff AI, Neville SE, Lum JS, Golen JA, Rheingold AL, Orth N, Ivanovic-Burmazovic I, Liebhäuser P, Rösener T, Stanek J, Hoffmann A, Herres-Pawlis S, Doerrer LH. PMID: 28236333.
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    90. Exhaustion-associated regulatory regions in CD8+ tumor-infiltrating T cells. Proc Natl Acad Sci U S A. 2017 03 28; 114(13):E2776-E2785. Mognol GP, Spreafico R, Wong V, Scott-Browne JP, Togher S, Hoffmann A, Hogan PG, Rao A, Trifari S. PMID: 28283662; PMCID: PMC5380094.
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    91. Iterative Modeling Reveals Evidence of Sequential Transcriptional Control Mechanisms. Cell Syst. 2017 03 22; 4(3):330-343.e5. Cheng CS, Behar MS, Suryawanshi GW, Feldman KE, Spreafico R, Hoffmann A. PMID: 28237795; PMCID: PMC5434763.
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    92. Functional importance of stripping in NFκB signaling revealed by a stripping-impaired IκBα mutant. Proc Natl Acad Sci U S A. 2017 02 21; 114(8):1916-1921. Dembinski HE, Wismer K, Vargas JD, Suryawanshi GW, Kern N, Kroon G, Dyson HJ, Hoffmann A, Komives EA. PMID: 28167786; PMCID: PMC5338396.
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    93. Early cytokine signatures of ischemia/reperfusion injury in human orthotopic liver transplantation. JCI Insight. 2016 12 08; 1(20):e89679. Sosa RA, Zarrinpar A, Rossetti M, Lassman CR, Naini BV, Datta N, Rao P, Harre N, Zheng Y, Spreafico R, Hoffmann A, Busuttil RW, Gjertson DW, Zhai Y, Kupiec-Weglinski JW, Reed EF. PMID: 27942590; PMCID: PMC5135282.
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    94. Experimental and Theoretical High-Energy-Resolution X-ray Absorption Spectroscopy: Implications for the Investigation of the Entatic State. Inorg Chem. 2016 Nov 21; 55(22):11694-11706. Vollmers NJ, M?ller P, Hoffmann A, Herres-Pawlis S, Rohrm?ller M, Schmidt WG, Gerstmann U, Bauer M. PMID: 27813403.
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    95. Oscillation dynamics underlie functional switching of NF-κB for B-cell activation. NPJ Syst Biol Appl. 2016; 2:16024. Inoue K, Shinohara H, Behar M, Yumoto N, Tanaka G, Hoffmann A, Aihara K, Okada-Hatakeyama M. PMID: 28725478; PMCID: PMC5516862.
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    96. Multi-level meta-workflows: new concept for regularly occurring tasks in quantum chemistry. J Cheminform. 2016; 8:58. Arshad J, Hoffmann A, Gesing S, Grunzke R, Kr?ger J, Kiss T, Herres-Pawlis S, Terstyanszky G. PMID: 27818709; PMCID: PMC5073744.
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    97. Homolytic, Heterolytic, Mesolytic - As You Like It: Steering the Cleavage of a HC(sp3 )-C(sp3 )H Bond in Bis(1H-2,1-benzazaborole) Derivatives. Chemistry. 2016 Oct 17; 22(43):15340-15349. Hejda M, Lycka A, Mikysek T, Jambor R, Ru?icka A, Vinkl?rek J, Wilfer C, Hoffmann A, Herres-Pawlis S, Dost?l L. PMID: 27619080.
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    98. A Comprehensive Study of Copper Guanidine Quinoline Complexes: Predicting the Activity of Catalysts in ATRP with DFT. Chemistry. 2016 Sep 12; 22(38):13550-62. R?sener T, Bienemann O, Sigl K, Schopp N, Schnitter F, Fl?rke U, Hoffmann A, D?ring A, Kuckling D, Herres-Pawlis S. PMID: 27505859.
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    99. A miR-155-Peli1-c-Rel pathway controls the generation and function of T follicular helper cells. J Exp Med. 2016 08 22; 213(9):1901-19. Liu WH, Kang SG, Huang Z, Wu CJ, Jin HY, Maine CJ, Liu Y, Shepherd J, Sabouri-Ghomi M, Gonzalez-Martin A, Xu S, Hoffmann A, Zheng Y, Lu LF, Xiao N, Fu G, Xiao C. PMID: 27481129; PMCID: PMC4995083.
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    100. Immune Response Signaling: Combinatorial and Dynamic Control. Trends Immunol. 2016 09; 37(9):570-572. Hoffmann A. PMID: 27461000; PMCID: PMC5003693.
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    101. High-Content Quantification of Single-Cell Immune Dynamics. Cell Rep. 2016 Apr 12; 15(2):411-22. Junkin M, Kaestli AJ, Cheng Z, Jordi C, Albayrak C, Hoffmann A, Tay S. PMID: 27050527; PMCID: PMC4835544.
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    102. Signaling via the NFκB system. Wiley Interdiscip Rev Syst Biol Med. 2016 05; 8(3):227-41. Mitchell S, Vargas J, Hoffmann A. PMID: 26990581; PMCID: PMC8363188.
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    103. The REGγ-proteasome forms a regulatory circuit with IκBɛ and NFκB in experimental colitis. Nat Commun. 2016 Feb 22; 7:10761. Xu J, Zhou L, Ji L, Chen F, Fortmann K, Zhang K, Liu Q, Li K, Wang W, Wang H, Xie W, Wang Q, Liu J, Zheng B, Zhang P, Huang S, Shi T, Zhang B, Dang Y, Chen J, O'Malley BW, Moses RE, Wang P, Li L, Xiao J, Hoffmann A, Li X. PMID: 26899380; PMCID: PMC4764899.
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    104. A stochastic spatio-temporal (SST) model to study cell-to-cell variability in HIV-1 infection. J Theor Biol. 2016 Apr 21; 395:87-96. Cheng Z, Hoffmann A. PMID: 26860658.
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    105. B-cell survival and development controlled by the coordination of NF-κB family members RelB and cRel. Blood. 2016 Mar 10; 127(10):1276-86. Almaden JV, Liu YC, Yang E, Otero DC, Birnbaum H, Davis-Turak J, Asagiri M, David M, Goldrath AW, Hoffmann A. PMID: 26773039; PMCID: PMC4786837.
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    106. Formation of hybrid guanidine-stabilized bis(�-oxo)dicopper cores in solution: Electronic and steric perturbations. Eur J Inorg Chem. 2015 Nov; 2015(32):5426-5436. Herres-Pawlis S, Haase R, Verma P, Hoffmann A, Kang P, Stack TD. PMID: 27990098; PMCID: PMC5158105.
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    108. A multi-scale mathematical modeling framework to investigate anti-viral therapeutic opportunities in targeting HIV-1 accessory proteins. J Theor Biol. 2015 Dec 07; 386:89-104. Suryawanshi GW, Hoffmann A. PMID: 26385832; PMCID: PMC4685255.
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    109. Anatomy of a negative feedback loop: the case of IκBα. J R Soc Interface. 2015 Sep 06; 12(110):0262. Fagerlund R, Behar M, Fortmann KT, Lin YE, Vargas JD, Hoffmann A. PMID: 26311312; PMCID: PMC4614452.
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    111. Distinct single-cell signaling characteristics are conferred by the MyD88 and TRIF pathways during TLR4 activation. Sci Signal. 2015 Jul 14; 8(385):ra69. Cheng Z, Taylor B, Ourthiague DR, Hoffmann A. PMID: 26175492; PMCID: PMC6764925.
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    112. The Cu2O2 torture track for a real-life system: [Cu2(btmgp)2O2](2+) oxo and peroxo species in density functional calculations. J Comput Chem. 2015 Aug 15; 36(22):1672-85. Rohrm?ller M, Hoffmann A, Thierfelder C, Herres-Pawlis S, Schmidt WG. PMID: 26153244.
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    114. Training the 21st Century Immunologist. Trends Immunol. 2015 May; 36(5):283-5. Spreafico R, Mitchell S, Hoffmann A. PMID: 25911462.
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    115. Limited specificity of IRF3 and ISGF3 in the transcriptional innate-immune response to double-stranded RNA. J Leukoc Biol. 2015 Jul; 98(1):119-28. Ourthiague DR, Birnbaum H, Ortenlöf N, Vargas JD, Wollman R, Hoffmann A. PMID: 25896227; PMCID: PMC4467169.
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    116. Less is more: three-coordinate c,n-chelated distannynes and digermynes. Chemistry. 2015 May 18; 21(21):7820-9. Nov?k M, Bou?ka M, Dost?l L, Ru?icka A, Hoffmann A, Herres-Pawlis S, Jambor R. PMID: 25877759.
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    117. Regulation and Function of the Caspase-1 in an Inflammatory Microenvironment. J Invest Dermatol. 2015 Aug; 135(8):2012-2020. Lee DJ, Du F, Chen SW, Nakasaki M, Rana I, Shih VFS, Hoffmann A, Jamora C. PMID: 25815426; PMCID: PMC4504759.
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    118. A multi-scale approach reveals that NF-κB cRel enforces a B-cell decision to divide. Mol Syst Biol. 2015 Feb 13; 11(1):783. Shokhirev MN, Almaden J, Davis-Turak J, Birnbaum HA, Russell TM, Vargas JA, Hoffmann A. PMID: 25680807; PMCID: PMC4358656.
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    119. Antimony(III) and bismuth(III) amides containing pendant N-donor groups--a combined experimental and theoretical study. Dalton Trans. 2015 Jan 07; 44(1):395-400. Vr?nov? I, Jambor R, Ru?icka A, Hoffmann A, Herres-Pawlis S, Dost?l L. PMID: 25385247.
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    121. Considering the kinetics of mRNA synthesis in the analysis of the genome and epigenome reveals determinants of co-transcriptional splicing. Nucleic Acids Res. 2015 Jan; 43(2):699-707. Davis-Turak JC, Allison K, Shokhirev MN, Ponomarenko P, Tsimring LS, Glass CK, Johnson TL, Hoffmann A. PMID: 25541195; PMCID: PMC4333389.
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    122. Systems biology. Accurate information transmission through dynamic biochemical signaling networks. Science. 2014 Dec 12; 346(6215):1370-3. Selimkhanov J, Taylor B, Yao J, Pilko A, Albeck J, Hoffmann A, Tsimring L, Wollman R. PMID: 25504722; PMCID: PMC4813785.
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    123. A pathway switch directs BAFF signaling to distinct NFκB transcription factors in maturing and proliferating B cells. Cell Rep. 2014 Dec 24; 9(6):2098-111. Almaden JV, Tsui R, Liu YC, Birnbaum H, Shokhirev MN, Ngo KA, Davis-Turak JC, Otero D, Basak S, Rickert RC, Hoffmann A. PMID: 25497099; PMCID: PMC4889572.
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    124. MAP kinase p38α regulates type III interferon (IFN-λ1) gene expression in human monocyte-derived dendritic cells in response to RNA stimulation. J Leukoc Biol. 2015 Feb; 97(2):307-20. Jiang M, Österlund P, Fagerlund R, Rios DN, Hoffmann A, Poranen MM, Bamford DH, Julkunen I. PMID: 25473098.
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    125. Network dynamics determine the autocrine and paracrine signaling functions of TNF. Genes Dev. 2014 Oct 01; 28(19):2120-33. Caldwell AB, Cheng Z, Vargas JD, Birnbaum HA, Hoffmann A. PMID: 25274725; PMCID: PMC4180974.
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    126. Geometrical and optical benchmarking of copper(II) guanidine-quinoline complexes: insights from TD-DFT and many-body perturbation theory (part II). J Comput Chem. 2014 Nov 05; 35(29):2146-61. Hoffmann A, Rohrm?ller M, Jesser A, dos Santos Vieira I, Schmidt WG, Herres-Pawlis S. PMID: 25255876.
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    127. Insights into the influence of dispersion correction in the theoretical treatment of guanidine-quinoline copper(I) complexes. J Comput Chem. 2014 Oct 15; 35(27):1943-50. Hoffmann A, Grunzke R, Herres-Pawlis S. PMID: 25124719.
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    128. Performance studies on distributed virtual screening. Biomed Res Int. 2014; 2014:624024. Krüger J, Grunzke R, Herres-Pawlis S, Hoffmann A, de la Garza L, Kohlbacher O, Nagel WE, Gesing S. PMID: 25032219; PMCID: PMC4083208.
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    129. Positive feedback within a kinase signaling complex functions as a switch mechanism for NF-κB activation. Science. 2014 May 16; 344(6185):760-4. Shinohara H, Behar M, Inoue K, Hiroshima M, Yasuda T, Nagashima T, Kimura S, Sanjo H, Maeda S, Yumoto N, Ki S, Akira S, Sako Y, Hoffmann A, Kurosaki T, Okada-Hatakeyama M. PMID: 24833394.
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    130. IκBε is a key regulator of B cell expansion by providing negative feedback on cRel and RelA in a stimulus-specific manner. J Immunol. 2014 Apr 01; 192(7):3121-32. Alves BN, Tsui R, Almaden J, Shokhirev MN, Davis-Turak J, Fujimoto J, Birnbaum H, Ponomarenko J, Hoffmann A. PMID: 24591377; PMCID: PMC3965642.
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    131. Hiking on the potential energy surface of a functional tyrosinase model--implications of singlet, broken-symmetry and triplet description. Chem Commun (Camb). 2014 Jan 14; 50(4):403-5. Hoffmann A, Herres-Pawlis S. PMID: 24212127.
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    132. Cross-talk between aryl hydrocarbon receptor and the inflammatory response: a role for nuclear factor-κB. J Biol Chem. 2014 Jan 17; 289(3):1866-75. Vogel CF, Khan EM, Leung PS, Gershwin ME, Chang WL, Wu D, Haarmann-Stemmann T, Hoffmann A, Denison MS. PMID: 24302727; PMCID: PMC3894361.
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    133. Catching an entatic state--a pair of copper complexes. Angew Chem Int Ed Engl. 2014 Jan 03; 53(1):299-304. Hoffmann A, Binder S, Jesser A, Haase R, Fl?rke U, Gnida M, Salomone Stagni M, Meyer-Klaucke W, Lebsanft B, Gr?nig LE, Schneider S, Hashemi M, Goos A, Wetzel A, R?bhausen M, Herres-Pawlis S. PMID: 24375742.
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    134. The dynamics of signaling as a pharmacological target. Cell. 2013 Oct 10; 155(2):448-61. Behar M, Barken D, Werner SL, Hoffmann A. PMID: 24120141; PMCID: PMC3856316.
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    135. Ex vivo innate immune cytokine signature of enhanced risk of relapsing brucellosis. PLoS Negl Trop Dis. 2013; 7(9):e2424. Feldman KE, Loriaux PM, Saito M, Tuero I, Villaverde H, Siva T, Gotuzzo E, Gilman RH, Hoffmann A, Vinetz JM. PMID: 24040434; PMCID: PMC3764229.
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    136. Analysis of the RelA:CBP/p300 interaction reveals its involvement in NF-κB-driven transcription. PLoS Biol. 2013 Sep; 11(9):e1001647. Mukherjee SP, Behar M, Birnbaum HA, Hoffmann A, Wright PE, Ghosh G. PMID: 24019758; PMCID: PMC3760798.
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    137. Chromatin-bound IκBα regulates a subset of polycomb target genes in differentiation and cancer. Cancer Cell. 2013 Aug 12; 24(2):151-66. Mulero MC, Ferres-Marco D, Islam A, Margalef P, Pecoraro M, Toll A, Drechsel N, Charneco C, Davis S, Bellora N, Gallardo F, López-Arribillaga E, Asensio-Juan E, Rodilla V, González J, Iglesias M, Shih V, Mar Albà M, Di Croce L, Hoffmann A, Miyamoto S, Villà-Freixa J, López-Bigas N, Keyes WM, Domínguez M, Bigas A, Espinosa L. PMID: 23850221; PMCID: PMC3962677.
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    138. Tunable signal processing through a kinase control cycle: the IKK signaling node. Biophys J. 2013 Jul 02; 105(1):231-41. Behar M, Hoffmann A. PMID: 23823243; PMCID: PMC3699752.
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    139. Dual delayed feedback provides sensitivity and robustness to the NF-κB signaling module. PLoS Comput Biol. 2013; 9(6):e1003112. Longo DM, Selimkhanov J, Kearns JD, Hasty J, Hoffmann A, Tsimring LS. PMID: 23825938; PMCID: PMC3694842.
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    140. FlowMax: A Computational Tool for Maximum Likelihood Deconvolution of CFSE Time Courses. PLoS One. 2013; 8(6):e67620. Shokhirev MN, Hoffmann A. PMID: 23826329; PMCID: PMC3694893.
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    141. A structural basis for IκB kinase 2 activation via oligomerization-dependent trans auto-phosphorylation. PLoS Biol. 2013; 11(6):e1001581. Polley S, Huang DB, Hauenstein AV, Fusco AJ, Zhong X, Vu D, Schröfelbauer B, Kim Y, Hoffmann A, Verma IM, Ghosh G, Huxford T. PMID: 23776406; PMCID: PMC3678999.
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    142. Catalytic phenol hydroxylation with dioxygen: extension of the tyrosinase mechanism beyond the protein matrix. Angew Chem Int Ed Engl. 2013 May 10; 52(20):5398-401. Hoffmann A, Citek C, Binder S, Goos A, R?bhausen M, Troeppner O, Ivanovic-Burmazovic I, Wasinger EC, Stack TD, Herres-Pawlis S. PMID: 23609983; PMCID: PMC3814313.
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    143. A protein turnover signaling motif controls the stimulus-sensitivity of stress response pathways. PLoS Comput Biol. 2013; 9(2):e1002932. Loriaux PM, Hoffmann A. PMID: 23468615; PMCID: PMC3585401.
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    144. Characterizing the relationship between steady state and response using analytical expressions for the steady states of mass action models. PLoS Comput Biol. 2013; 9(2):e1002901. Loriaux PM, Tesler G, Hoffmann A. PMID: 23509437; PMCID: PMC3585464.
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    145. ER stress activates NF-κB by integrating functions of basal IKK activity, IRE1 and PERK. PLoS One. 2012; 7(10):e45078. Tam AB, Mercado EL, Hoffmann A, Niwa M. PMID: 23110043; PMCID: PMC3482226.
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    146. Control of RelB during dendritic cell activation integrates canonical and noncanonical NF-κB pathways. Nat Immunol. 2012 Dec; 13(12):1162-70. Shih VF, Davis-Turak J, Macal M, Huang JQ, Ponomarenko J, Kearns JD, Yu T, Fagerlund R, Asagiri M, Zuniga EI, Hoffmann A. PMID: 23086447; PMCID: PMC3634611.
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    147. The transcriptional specificity of NF-κB dimers is coded within the κB DNA response elements. Cell Rep. 2012 Oct 25; 2(4):824-39. Wang VY, Huang W, Asagiri M, Spann N, Hoffmann A, Glass C, Ghosh G. PMID: 23063365; PMCID: PMC4167904.
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    148. NEMO ensures signaling specificity of the pleiotropic IKKβ by directing its kinase activity toward IκBα. Mol Cell. 2012 Jul 13; 47(1):111-21. Schröfelbauer B, Polley S, Behar M, Ghosh G, Hoffmann A. PMID: 22633953; PMCID: PMC3398199.
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    149. Paternal RLIM/Rnf12 is a survival factor for milk-producing alveolar cells. Cell. 2012 Apr 27; 149(3):630-41. Jiao B, Ma H, Shokhirev MN, Drung A, Yang Q, Shin J, Lu S, Byron M, Kalantry S, Mercurio AM, Lawrence JB, Hoffmann A, Bach I. PMID: 22541433; PMCID: PMC3342660.
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    150. Lessons from mathematically modeling the NF-κB pathway. Immunol Rev. 2012 Mar; 246(1):221-38. Basak S, Behar M, Hoffmann A. PMID: 22435558; PMCID: PMC3343698.
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    151. A framework for modeling the relationship between cellular steady-state and stimulus-responsiveness. Methods Cell Biol. 2012; 110:81-109. Loriaux PM, Hoffmann A. PMID: 22482946; PMCID: PMC5763568.
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    152. Mechanisms establishing TLR4-responsive activation states of inflammatory response genes. PLoS Genet. 2011 Dec; 7(12):e1002401. Escoubet-Lozach L, Benner C, Kaikkonen MU, Lozach J, Heinz S, Spann NJ, Crotti A, Stender J, Ghisletti S, Reichart D, Cheng CS, Luna R, Ludka C, Sasik R, Garcia-Bassets I, Hoffmann A, Subramaniam S, Hardiman G, Rosenfeld MG, Glass CK. PMID: 22174696; PMCID: PMC3234212.
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    153. NF-κB–inducing kinase plays an essential T cell–intrinsic role in graft-versus-host disease and lethal autoimmunity in mice. J Clin Invest. 2011 Dec; 121(12):4775-86. Murray SE, Polesso F, Rowe AM, Basak S, Koguchi Y, Toren KG, Hoffmann A, Parker DC. PMID: 22045568; PMCID: PMC3223068.
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    154. How do pleiotropic kinase hubs mediate specific signaling by TNFR superfamily members? Immunol Rev. 2011 Nov; 244(1):29-43. Schröfelbauer B, Hoffmann A. PMID: 22017429; PMCID: PMC3357464.
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    155. The specificity of innate immune responses is enforced by repression of interferon response elements by NF-κB p50. Sci Signal. 2011 Feb 22; 4(161):ra11. Cheng CS, Feldman KE, Lee J, Verma S, Huang DB, Huynh K, Chang M, Ponomarenko JV, Sun SC, Benedict CA, Ghosh G, Hoffmann A. PMID: 21343618; PMCID: PMC3096068.
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    156. Nuclear export of the NF-κB inhibitor IκBα is required for proper B cell and secondary lymphoid tissue formation. Immunity. 2011 Feb 25; 34(2):188-200. Wuerzberger-Davis SM, Chen Y, Yang DT, Kearns JD, Bates PW, Lynch C, Ladell NC, Yu M, Podd A, Zeng H, Huang TT, Wen R, Hoffmann A, Wang D, Miyamoto S. PMID: 21333553; PMCID: PMC3111750.
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    157. NF-κB potentiates caspase independent hydrogen peroxide induced cell death. PLoS One. 2011 Feb 15; 6(2):e16815. Ho JQ, Asagiri M, Hoffmann A, Ghosh G. PMID: 21347231; PMCID: PMC3039651.
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    158. Understanding the logic of IκB:NF-κB regulation in structural terms. Curr Top Microbiol Immunol. 2011; 349:1-24. Huxford T, Hoffmann A, Ghosh G. PMID: 20845107.
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    159. A single NFκB system for both canonical and non-canonical signaling. Cell Res. 2011 Jan; 21(1):86-102. Shih VF, Tsui R, Caldwell A, Hoffmann A. PMID: 21102550; PMCID: PMC3193412.
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    160. Systems biology of cellular rhythms: from cacophony to symphony. Curr Opin Genet Dev. 2010 Dec; 20(6):571-3. Hasty J, Hoffmann A, Golden S. PMID: 21036033; PMCID: PMC4734115.
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    161. Understanding the temporal codes of intra-cellular signals. Curr Opin Genet Dev. 2010 Dec; 20(6):684-93. Behar M, Hoffmann A. PMID: 20956081; PMCID: PMC2982931.
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    162. IkappaBbeta acts to inhibit and activate gene expression during the inflammatory response. Nature. 2010 Aug 26; 466(7310):1115-9. Rao P, Hayden MS, Long M, Scott ML, West AP, Zhang D, Oeckinghaus A, Lynch C, Hoffmann A, Baltimore D, Ghosh S. PMID: 20740013; PMCID: PMC2946371.
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    163. Defective regulation of CXCR2 facilitates neutrophil release from bone marrow causing spontaneous inflammation in severely NF-kappa B-deficient mice. J Immunol. 2010 Jul 01; 185(1):670-8. von Vietinghoff S, Asagiri M, Azar D, Hoffmann A, Ley K. PMID: 20519647; PMCID: PMC2891140.
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    164. Differential activation and antagonistic function of HIF-{alpha} isoforms in macrophages are essential for NO homeostasis. Genes Dev. 2010 Mar 01; 24(5):491-501. Takeda N, O'Dea EL, Doedens A, Kim JW, Weidemann A, Stockmann C, Asagiri M, Simon MC, Hoffmann A, Johnson RS. PMID: 20194441; PMCID: PMC2827844.
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    165. The regulatory logic of the NF-kappaB signaling system. Cold Spring Harb Perspect Biol. 2010 Jan; 2(1):a000216. O'Dea E, Hoffmann A. PMID: 20182598; PMCID: PMC2827908.
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    166. Kinetic enhancement of NF-kappaBxDNA dissociation by IkappaBalpha. Proc Natl Acad Sci U S A. 2009 Nov 17; 106(46):19328-33. Bergqvist S, Alverdi V, Mengel B, Hoffmann A, Ghosh G, Komives EA. PMID: 19887633; PMCID: PMC2780789.
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    167. Coherent activation of a synthetic mammalian gene network. Syst Synth Biol. 2010 Mar; 4(1):15-23. Longo DM, Hoffmann A, Tsimring LS, Hasty J. PMID: 19757189; PMCID: PMC2816225.
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    168. A unifying model for the selective regulation of inducible transcription by CpG islands and nucleosome remodeling. Cell. 2009 Jul 10; 138(1):114-28. Ramirez-Carrozzi VR, Braas D, Bhatt DM, Cheng CS, Hong C, Doty KR, Black JC, Hoffmann A, Carey M, Smale ST. PMID: 19596239; PMCID: PMC2712736.
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    169. NF-κB signaling. Wiley Interdiscip Rev Syst Biol Med. 2009 Jul-Aug; 1(1):107-115. O'Dea E, Hoffmann A. PMID: 20151024; PMCID: PMC2819170.
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    170. The Nfkb1 and Nfkb2 proteins p105 and p100 function as the core of high-molecular-weight heterogeneous complexes. Mol Cell. 2009 Jun 12; 34(5):591-602. Savinova OV, Hoffmann A, Ghosh G. PMID: 19524538; PMCID: PMC4167889.
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    171. Kinetic control of negative feedback regulators of NF-kappaB/RelA determines their pathogen- and cytokine-receptor signaling specificity. Proc Natl Acad Sci U S A. 2009 Jun 16; 106(24):9619-24. Shih VF, Kearns JD, Basak S, Savinova OV, Ghosh G, Hoffmann A. PMID: 19487661; PMCID: PMC2701028.
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    172. Of elections and cell-death decisions. Mol Cell. 2009 May 15; 34(3):257-8. Loriaux P, Hoffmann A. PMID: 19450524; PMCID: PMC3703440.
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    173. Antigen-mediated T cell expansion regulated by parallel pathways of death. Proc Natl Acad Sci U S A. 2008 Nov 11; 105(45):17463-8. Ch'en IL, Beisner DR, Degterev A, Lynch C, Yuan J, Hoffmann A, Hedrick SM. PMID: 18981423; PMCID: PMC2582294.
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    174. Integrating computational and biochemical studies to explore mechanisms in NF-{kappa}B signaling. J Biol Chem. 2009 Feb 27; 284(9):5439-43. Kearns JD, Hoffmann A. PMID: 18940809; PMCID: PMC2645808.
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    175. Encoding NF-kappaB temporal control in response to TNF: distinct roles for the negative regulators IkappaBalpha and A20. Genes Dev. 2008 Aug 01; 22(15):2093-101. Werner SL, Kearns JD, Zadorozhnaya V, Lynch C, O'Dea E, Boldin MP, Ma A, Baltimore D, Hoffmann A. PMID: 18676814; PMCID: PMC2492747.
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    176. UV as an amplifier rather than inducer of NF-kappaB activity. Mol Cell. 2008 Jun 06; 30(5):632-41. O'Dea EL, Kearns JD, Hoffmann A. PMID: 18538661; PMCID: PMC2682114.
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    177. Crosstalk via the NF-kappaB signaling system. Cytokine Growth Factor Rev. 2008 Jun-Aug; 19(3-4):187-97. Basak S, Hoffmann A. PMID: 18515173; PMCID: PMC2675004.
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    178. Understanding NF-kappaB signaling via mathematical modeling. Mol Syst Biol. 2008; 4:192. Cheong R, Hoffmann A, Levchenko A. PMID: 18463616; PMCID: PMC2424295.
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    179. Epigenetic control: slow and global, nimble and local. Genes Dev. 2008 May 01; 22(9):1110-4. Cheng CS, Johnson TL, Hoffmann A. PMID: 18451102; PMCID: PMC2732403.
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    180. Negative regulation of constitutive NF-kappaB and JNK signaling by PKN1-mediated phosphorylation of TRAF1. Genes Cells. 2008 May; 13(5):509-20. Kato T, Gotoh Y, Hoffmann A, Ono Y. PMID: 18429822.
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    181. NF-kappaB dictates the degradation pathway of IkappaBalpha. EMBO J. 2008 May 07; 27(9):1357-67. Mathes E, O'Dea EL, Hoffmann A, Ghosh G. PMID: 18401342; PMCID: PMC2374849.
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    182. Stabilization of RelB requires multidomain interactions with p100/p52. J Biol Chem. 2008 May 02; 283(18):12324-32. Fusco AJ, Savinova OV, Talwar R, Kearns JD, Hoffmann A, Ghosh G. PMID: 18321863; PMCID: PMC2431000.
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    183. Generation and activation of multiple dimeric transcription factors within the NF-kappaB signaling system. Mol Cell Biol. 2008 May; 28(10):3139-50. Basak S, Shih VF, Hoffmann A. PMID: 18299388; PMCID: PMC2423155.
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    184. NF-kappaB as a determinant of distinct cell death pathways. Methods Enzymol. 2008; 446:175-87. Ch'en IL, Hedrick SM, Hoffmann A. PMID: 18603122.
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    185. A homeostatic model of IkappaB metabolism to control constitutive NF-kappaB activity. Mol Syst Biol. 2007; 3:111. O'Dea EL, Barken D, Peralta RQ, Tran KT, Werner SL, Kearns JD, Levchenko A, Hoffmann A. PMID: 17486138; PMCID: PMC2673708.
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    186. Inflammatory tales of liver cancer. Cancer Cell. 2007 Feb; 11(2):99-101. Hoffmann A, Xia Y, Verma IM. PMID: 17292819.
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    187. A fourth IkappaB protein within the NF-kappaB signaling module. Cell. 2007 Jan 26; 128(2):369-81. Basak S, Kim H, Kearns JD, Tergaonkar V, O'Dea E, Werner SL, Benedict CA, Ware CF, Ghosh G, Verma IM, Hoffmann A. PMID: 17254973; PMCID: PMC1831796.
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    188. IkappaBepsilon provides negative feedback to control NF-kappaB oscillations, signaling dynamics, and inflammatory gene expression. J Cell Biol. 2006 Jun 05; 173(5):659-64. Kearns JD, Basak S, Werner SL, Huang CS, Hoffmann A. PMID: 16735576; PMCID: PMC2063883.
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    189. Circuitry of nuclear factor kappaB signaling. Immunol Rev. 2006 Apr; 210:171-86. Hoffmann A, Baltimore D. PMID: 16623771.
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    190. Transient IkappaB kinase activity mediates temporal NF-kappaB dynamics in response to a wide range of tumor necrosis factor-alpha doses. J Biol Chem. 2006 Feb 03; 281(5):2945-50. Cheong R, Bergmann A, Werner SL, Regal J, Hoffmann A, Levchenko A. PMID: 16321974.
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    191. Coordination between NF-kappaB family members p50 and p52 is essential for mediating LTbetaR signals in the development and organization of secondary lymphoid tissues. Blood. 2006 Feb 01; 107(3):1048-55. Lo JC, Basak S, James ES, Quiambo RS, Kinsella MC, Alegre ML, Weih F, Franzoso G, Hoffmann A, Fu YX. PMID: 16195333; PMCID: PMC1895903.
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    192. Immortalized fibroblasts from NF-kappaB RelA knockout mice show phenotypic heterogeneity and maintain increased sensitivity to tumor necrosis factor alpha after transformation by v-Ras. Oncogene. 2005 Sep 29; 24(43):6574-83. Gapuzan ME, Schmah O, Pollock AD, Hoffmann A, Gilmore TD. PMID: 16027734.
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    193. Stimulus specificity of gene expression programs determined by temporal control of IKK activity. Science. 2005 Sep 16; 309(5742):1857-61. Werner SL, Barken D, Hoffmann A. PMID: 16166517.
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    194. Cutting edge: innate immunity conferred by B cells is regulated by caspase-8. J Immunol. 2005 Sep 15; 175(6):3469-73. Beisner DR, Ch'en IL, Kolla RV, Hoffmann A, Hedrick SM. PMID: 16148088.
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    195. A c-Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation. Genes Dev. 2005 Sep 15; 19(18):2138-51. Sanjabi S, Williams KJ, Saccani S, Zhou L, Hoffmann A, Ghosh G, Gerondakis S, Natoli G, Smale ST. PMID: 16166378; PMCID: PMC1221885.
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    196. Molecular determinants of crosstalk between nuclear receptors and toll-like receptors. Cell. 2005 Sep 09; 122(5):707-21. Ogawa S, Lozach J, Benner C, Pascual G, Tangirala RK, Westin S, Hoffmann A, Subramaniam S, David M, Rosenfeld MG, Glass CK. PMID: 16143103; PMCID: PMC1430687.
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    197. Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulators. Immunity. 2005 Sep; 23(3):319-29. Park JM, Greten FR, Wong A, Westrick RJ, Arthur JS, Otsu K, Hoffmann A, Montminy M, Karin M. PMID: 16169504.
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    198. Initiation and termination of NF-kappaB signaling by the intracellular protozoan parasite Toxoplasma gondii. J Cell Sci. 2005 Aug 01; 118(Pt 15):3501-8. Shapira S, Harb OS, Margarit J, Matrajt M, Han J, Hoffmann A, Freedman B, May MJ, Roos DS, Hunter CA. PMID: 16079291.
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    199. Induction of NR4A orphan nuclear receptor expression in macrophages in response to inflammatory stimuli. J Biol Chem. 2005 Aug 12; 280(32):29256-62. Pei L, Castrillo A, Chen M, Hoffmann A, Tontonoz P. PMID: 15964844.
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    200. Comment on "Oscillations in NF-kappaB signaling control the dynamics of gene expression". Science. 2005 Apr 01; 308(5718):52; author reply 52. Barken D, Wang CJ, Kearns J, Cheong R, Hoffmann A, Levchenko A. PMID: 15802586; PMCID: PMC2821939.
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    201. One nucleotide in a kappaB site can determine cofactor specificity for NF-kappaB dimers. Cell. 2004 Aug 20; 118(4):453-64. Leung TH, Hoffmann A, Baltimore D. PMID: 15315758.
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    202. Unique CD40-mediated biological program in B cell activation requires both type 1 and type 2 NF-kappaB activation pathways. Proc Natl Acad Sci U S A. 2004 May 25; 101(21):8108-13. Zarnegar B, He JQ, Oganesyan G, Hoffmann A, Baltimore D, Cheng G. PMID: 15148378; PMCID: PMC419565.
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    203. Genetic analysis of NF-kappaB/Rel transcription factors defines functional specificities. EMBO J. 2003 Oct 15; 22(20):5530-9. Hoffmann A, Leung TH, Baltimore D. PMID: 14532125; PMCID: PMC213788.
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    204. CK2 Is a C-Terminal IkappaB Kinase Responsible for NF-kappaB Activation during the UV Response. Mol Cell. 2003 Oct; 12(4):829-39. Kato T, Delhase M, Hoffmann A, Karin M. PMID: 14580335.
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    205. The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation. Science. 2002 Nov 08; 298(5596):1241-5. Hoffmann A, Levchenko A, Scott ML, Baltimore D. PMID: 12424381.
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    206. Cooperation of multiple signaling pathways in CD40-regulated gene expression in B lymphocytes. Proc Natl Acad Sci U S A. 2002 Feb 05; 99(3):1497-502. Dadgostar H, Zarnegar B, Hoffmann A, Qin XF, Truong U, Rao G, Baltimore D, Cheng G. PMID: 11830667; PMCID: PMC122219.
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