Alexander Hoffmann
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Title(s) | Professor, MIMG |
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School | Medicine |
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Address | 611 Charles E. Young Drive, Ea 162 Los Angeles CA 90024
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Phone | 3107949925 |
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vCard | Download vCard |
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Research Bibliographic
Altmetrics Details
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media.
(Note that publications are often cited in additional ways that are not shown here.)
Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
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Click a Field or Translation tag to filter the publications.
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Quantifying information accumulation encoded in the dynamics of biochemical signaling. Nat Commun. 2021 02 24; 12(1):1272.
Tang Y, Adelaja A, Ye FX, Deeds E, Wollman R, Hoffmann A. PMID: 33627672.
View in: PubMed Mentions: Fields: Translation: HumansCells
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An incoherent feedforward loop interprets NF?B/RelA dynamics to determine TNF-induced necroptosis decisions. Mol Syst Biol. 2020 Dec; 16(12):e9677.
Oliver Metzig M, Tang Y, Mitchell S, Taylor B, Foreman R, Wollman R, Hoffmann A. PMID: 33314666.
View in: PubMed Mentions: Fields:
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Dissecting the Regulatory Strategies of NF-κB RelA Target Genes in the Inflammatory Response Reveals Differential Transactivation Logics. Cell Rep. 2020 02 25; 30(8):2758-2775.e6.
Ngo KA, Kishimoto K, Davis-Turak J, Pimplaskar A, Cheng Z, Spreafico R, Chen EY, Tam A, Ghosh G, Mitchell S, Hoffmann A. PMID: 32101750.
View in: PubMed Mentions: 2 Fields:
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Gene Regulatory Strategies that Decode the Duration of NF?B Dynamics Contribute to LPS- versus TNF-Specific Gene Expression. Cell Syst. 2020 02 26; 10(2):169-182.e5.
Sen S, Cheng Z, Sheu KM, Chen YH, Hoffmann A. PMID: 31972132.
View in: PubMed Mentions: 3 Fields:
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Stimulus-specificity in the Responses of Immune Sentinel Cells. Curr Opin Syst Biol. 2019 Dec; 18:53-61.
Sheu K, Luecke S, Hoffmann A. PMID: 32864512.
View in: PubMed Mentions:
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Identifying determinants of persistent MRSA bacteremia using mathematical modeling. PLoS Comput Biol. 2019 07; 15(7):e1007087.
Mikkaichi T, Yeaman MR, Hoffmann A. PMID: 31295255.
View in: PubMed Mentions: 2 Fields: Translation: HumansCells
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Signaling Crosstalk Mechanisms That May Fine-Tune Pathogen-Responsive NF?B. Front Immunol. 2019; 10:433.
Adelaja A, Hoffmann A. PMID: 31312197.
View in: PubMed Mentions: 3 Fields: Translation: HumansAnimalsCells
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An NF?B Activity Calculator to Delineate Signaling Crosstalk: Type I and II Interferons Enhance NF?B via Distinct Mechanisms. Front Immunol. 2019; 10:1425.
Mitchell S, Mercado EL, Adelaja A, Ho JQ, Cheng QJ, Ghosh G, Hoffmann A. PMID: 31293585.
View in: PubMed Mentions: 1 Fields: Translation: AnimalsCells
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Substrate complex competition is a regulatory motif that allows NF?B RelA to license but not amplify NF?B RelB. Proc Natl Acad Sci U S A. 2019 05 21; 116(21):10592-10597.
Mitchell S, Hoffmann A. PMID: 31048505.
View in: PubMed Mentions: Fields: Translation: Cells
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Sequential conditioning-stimulation reveals distinct gene- and stimulus-specific effects of Type I and II IFN on human macrophage functions. Sci Rep. 2019 03 27; 9(1):5288.
Cheng Q, Behzadi F, Sen S, Ohta S, Spreafico R, Teles R, Modlin RL, Hoffmann A. PMID: 30918279.
View in: PubMed Mentions: 3 Fields: Translation: HumansCells
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A Regulatory Circuit Controlling the Dynamics of NF?B cRel Transitions B Cells from Proliferation to Plasma Cell Differentiation. Immunity. 2019 03 19; 50(3):616-628.e6.
Roy K, Mitchell S, Liu Y, Ohta S, Lin YS, Metzig MO, Nutt SL, Hoffmann A. PMID: 30850343.
View in: PubMed Mentions: 9 Fields: Translation: HumansAnimalsCells
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Polypyrimidine tract-binding protein blocks miRNA-124 biogenesis to enforce its neuronal-specific expression in the mouse. Proc Natl Acad Sci U S A. 2018 11 20; 115(47):E11061-E11070.
Yeom KH, Mitchell S, Linares AJ, Zheng S, Lin CH, Wang XJ, Hoffmann A, Black DL. PMID: 30401736.
View in: PubMed Mentions: 2 Fields: Translation: AnimalsCells
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Nongenetic origins of cell-to-cell variability in B lymphocyte proliferation. Proc Natl Acad Sci U S A. 2018 03 20; 115(12):E2888-E2897.
Mitchell S, Roy K, Zangle TA, Hoffmann A. PMID: 29514960.
View in: PubMed Mentions: 10 Fields: Translation: AnimalsCells
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Deriving Quantitative Cell Biological Information from Dye-Dilution Lymphocyte Proliferation Experiments. Methods Mol Biol. 2018; 1707:81-94.
Roy K, Shokhirev MN, Mitchell S, Hoffmann A. PMID: 29388101.
View in: PubMed Mentions: Fields: Translation: HumansAnimalsCells
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Identifying Noise Sources governing cell-to-cell variability. Curr Opin Syst Biol. 2018 Apr; 8:39-45.
Mitchell S, Hoffmann A. PMID: 29623300.
View in: PubMed Mentions:
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Addressing the Digital Divide in Contemporary Biology: Lessons from Teaching UNIX. Trends Biotechnol. 2017 10; 35(10):901-903.
Mangul S, Martin LS, Hoffmann A, Pellegrini M, Eskin E. PMID: 28720283.
View in: PubMed Mentions: 5 Fields:
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Immune Response Signaling: Combinatorial and Dynamic Control. Trends Immunol. 2016 09; 37(9):570-572.
Hoffmann A. PMID: 27461000.
View in: PubMed Mentions: 5 Fields: Translation: HumansAnimalsCells
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High-Content Quantification of Single-Cell Immune Dynamics. Cell Rep. 2016 Apr 12; 15(2):411-22.
Junkin M, Kaestli AJ, Cheng Z, Jordi C, Albayrak C, Hoffmann A, Tay S. PMID: 27050527.
View in: PubMed Mentions: 27 Fields: Translation: AnimalsCells
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Signaling via the NF?B system. Wiley Interdiscip Rev Syst Biol Med. 2016 05; 8(3):227-41.
Mitchell S, Vargas J, Hoffmann A. PMID: 26990581.
View in: PubMed Mentions: 111 Fields: Translation: HumansAnimalsCells
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A stochastic spatio-temporal (SST) model to study cell-to-cell variability in HIV-1 infection. J Theor Biol. 2016 Apr 21; 395:87-96.
Cheng Z, Hoffmann A. PMID: 26860658.
View in: PubMed Mentions: Fields: Translation: HumansCells
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A multi-scale mathematical modeling framework to investigate anti-viral therapeutic opportunities in targeting HIV-1 accessory proteins. J Theor Biol. 2015 Dec 07; 386:89-104.
Suryawanshi GW, Hoffmann A. PMID: 26385832.
View in: PubMed Mentions: 1 Fields: Translation: HumansCells
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Distinct single-cell signaling characteristics are conferred by the MyD88 and TRIF pathways during TLR4 activation. Sci Signal. 2015 Jul 14; 8(385):ra69.
Cheng Z, Taylor B, Ourthiague DR, Hoffmann A. PMID: 26175492.
View in: PubMed Mentions: 34 Fields: Translation: AnimalsCells
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Training the 21st Century Immunologist. Trends Immunol. 2015 May; 36(5):283-5.
Spreafico R, Mitchell S, Hoffmann A. PMID: 25911462.
View in: PubMed Mentions: 5 Fields: Translation: Humans
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Limited specificity of IRF3 and ISGF3 in the transcriptional innate-immune response to double-stranded RNA. J Leukoc Biol. 2015 Jul; 98(1):119-28.
Ourthiague DR, Birnbaum H, Ortenlöf N, Vargas JD, Wollman R, Hoffmann A. PMID: 25896227.
View in: PubMed Mentions: 8 Fields: Translation: AnimalsCells
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Studying NF-κB signaling with mathematical models. Methods Mol Biol. 2015; 1280:647-61.
Mitchell S, Tsui R, Hoffmann A. PMID: 25736777.
View in: PubMed Mentions: 1 Fields: Translation: Cells
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MAP kinase p38a regulates type III interferon (IFN-?1) gene expression in human monocyte-derived dendritic cells in response to RNA stimulation. J Leukoc Biol. 2015 Feb; 97(2):307-20.
Jiang M, Österlund P, Fagerlund R, Rios DN, Hoffmann A, Poranen MM, Bamford DH, Julkunen I. PMID: 25473098.
View in: PubMed Mentions: 6 Fields: Translation: HumansAnimalsCells
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The dynamics of signaling as a pharmacological target. Cell. 2013 Oct 10; 155(2):448-61.
Behar M, Barken D, Werner SL, Hoffmann A. PMID: 24120141.
View in: PubMed Mentions: 54 Fields: Translation: HumansAnimalsCells
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Mechanisms establishing TLR4-responsive activation states of inflammatory response genes. PLoS Genet. 2011 Dec; 7(12):e1002401.
Escoubet-Lozach L, Benner C, Kaikkonen MU, Lozach J, Heinz S, Spann NJ, Crotti A, Stender J, Ghisletti S, Reichart D, Cheng CS, Luna R, Ludka C, Sasik R, Garcia-Bassets I, Hoffmann A, Subramaniam S, Hardiman G, Rosenfeld MG, Glass CK. PMID: 22174696.
View in: PubMed Mentions: 60 Fields: Translation: HumansAnimalsCells
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A unifying model for the selective regulation of inducible transcription by CpG islands and nucleosome remodeling. Cell. 2009 Jul 10; 138(1):114-28.
Ramirez-Carrozzi VR, Braas D, Bhatt DM, Cheng CS, Hong C, Doty KR, Black JC, Hoffmann A, Carey M, Smale ST. PMID: 19596239.
View in: PubMed Mentions: 252 Fields: Translation: HumansAnimalsCells
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Stimulus specificity of gene expression programs determined by temporal control of IKK activity. Science. 2005 Sep 16; 309(5742):1857-61.
Werner SL, Barken D, Hoffmann A. PMID: 16166517.
View in: PubMed Mentions: 215 Fields: Translation: AnimalsCells
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A c-Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation. Genes Dev. 2005 Sep 15; 19(18):2138-51.
Sanjabi S, Williams KJ, Saccani S, Zhou L, Hoffmann A, Ghosh G, Gerondakis S, Natoli G, Smale ST. PMID: 16166378.
View in: PubMed Mentions: 53 Fields: Translation: AnimalsCells
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Molecular determinants of crosstalk between nuclear receptors and toll-like receptors. Cell. 2005 Sep 09; 122(5):707-21.
Ogawa S, Lozach J, Benner C, Pascual G, Tangirala RK, Westin S, Hoffmann A, Subramaniam S, David M, Rosenfeld MG, Glass CK. PMID: 16143103.
View in: PubMed Mentions: 229 Fields: Translation: AnimalsCells
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Induction of NR4A orphan nuclear receptor expression in macrophages in response to inflammatory stimuli. J Biol Chem. 2005 Aug 12; 280(32):29256-62.
Pei L, Castrillo A, Chen M, Hoffmann A, Tontonoz P. PMID: 15964844.
View in: PubMed Mentions: 86 Fields: Translation: HumansAnimalsCells
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Unique CD40-mediated biological program in B cell activation requires both type 1 and type 2 NF-kappaB activation pathways. Proc Natl Acad Sci U S A. 2004 May 25; 101(21):8108-13.
Zarnegar B, He JQ, Oganesyan G, Hoffmann A, Baltimore D, Cheng G. PMID: 15148378.
View in: PubMed Mentions: 34 Fields: Translation: AnimalsCells
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Cooperation of multiple signaling pathways in CD40-regulated gene expression in B lymphocytes. Proc Natl Acad Sci U S A. 2002 Feb 05; 99(3):1497-502.
Dadgostar H, Zarnegar B, Hoffmann A, Qin XF, Truong U, Rao G, Baltimore D, Cheng G. PMID: 11830667.
View in: PubMed Mentions: 26 Fields: Translation: AnimalsCells
This graph shows the total number of publications by year. To see the data as text, click here.
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Year | Publications |
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2002 | 1 | 2004 | 1 | 2005 | 4 | 2009 | 1 | 2011 | 1 | 2013 | 1 | 2014 | 1 | 2015 | 5 | 2016 | 4 | 2017 | 2 | 2018 | 3 | 2019 | 7 | 2020 | 3 | 2021 | 1 |
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
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