Man Hing Li

Title(s)Associate Professor, MIMG
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    Collapse Biography 
    Collapse Education and Training
    University of California, Irvine, IrvineB.S.03/2006Biological Sciences
    University of Washington, Seattle, SeattlePh.D.04/2011Microbiology
    The Rockefeller University, New York08/2017Virology

    Collapse Overview 
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    The host innate immune response is the first line of defense against viral infections. Cytosolic sensors in the host cell recognize the incoming virus and stimulate the production of types I and III interferons (IFNs) with direct antiviral activities. The same or neighboring cell binds secreted IFNs and triggers the JAK/STAT signaling pathway resulting in the expression of a wide array of IFN-stimulated genes (ISGs). Many of these ISGs target different steps of the viral life cycle, but only some of them have been characterized. A main focus of the Li Lab is to elucidate the mechanisms of antiviral IFNs and ISGs using molecular biology, biochemistry, genome-wide approaches, and stem cell culture systems. We are studying the host and viral determinants that modulate viral infections in the presence of antiviral ISGs in different cell contexts using arthropod-borne alphaviruses as our model system. Several projects in the lab focus on the mechanism of zinc finger antiviral protein (ZAP), a broad-spectrum antiviral ISG that inhibits a broad range of viruses, and how it synergizes with its co-factor, the host E3 ubiquitin ligase TRIM25. Understanding the antiviral mechanisms of ISGs not only will shed light on how the host distinguishes between self and non-self, but it will also uncover viral antagonism strategies of the host innate immune response that drive increased viral virulence and pathogenesis.
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    Collapse Research Activities and Funding
    The Role of Viral Fragments in Long-Term Cardiovascular Sequelae of COVID-19
    American Heart Association 966662Apr 1, 2022 - Mar 31, 2025
    Role: Co-Investigator
    Functional analysis of host and viral determinants for ZAP inhibition
    NIH R01AI158704Apr 1, 2021 - Mar 31, 2026
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Moiré Pattern Controlled Phonon Polarizer Based on Twisted Graphene. Adv Mater. 2024 Jun; 36(24):e2312176. Qin Z, Dai L, Li M, Li S, Wu H, White KE, Gani G, Weiss PS, Hu Y. PMID: 38429904; PMCID: PMC11180428.
      View in: PubMed   Mentions:    Fields:    
    2. Positive selection analyses identify a single WWE domain residue that shapes ZAP into a super restriction factor. bioRxiv. 2023 Nov 20. Huang S, Girdner J, Nguyen LP, Enard D, Li MM. PMID: 38045310; PMCID: PMC10690157.
      View in: PubMed   Mentions:
    3. Chikungunya virus glycoproteins transform macrophages into productive viral dissemination vessels. bioRxiv. 2023 May 29. Yao Z, Ramachandran S, Huang S, Jami-Alahmadi Y, Wohlschlegel JA, Li MMH. PMID: 37398144; PMCID: PMC10312455.
      View in: PubMed   Mentions:
    4. Alphavirus Evasion of Zinc Finger Antiviral Protein (ZAP) Correlates with CpG Suppression in a Specific Viral nsP2 Gene Sequence. Viruses. 2023 03 24; 15(4). Nguyen LP, Aldana KS, Yang E, Yao Z, Li MMH. PMID: 37112813; PMCID: PMC10145277.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    5. Elucidation of TRIM25 ubiquitination targets involved in diverse cellular and antiviral processes. PLoS Pathog. 2022 09; 18(9):e1010743. Yang E, Huang S, Jami-Alahmadi Y, McInerney GM, Wohlschlegel JA, Li MMH. PMID: 36067236; PMCID: PMC9481182.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    6. The Role of ZAP and TRIM25 RNA Binding in Restricting Viral Translation. Front Cell Infect Microbiol. 2022; 12:886929. Yang E, Nguyen LP, Wisherop CA, Kan RL, Li MMH. PMID: 35800389; PMCID: PMC9253567.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    7. Intrinsic antiviral immunity of barrier cells revealed by an iPSC-derived blood-brain barrier cellular model. Cell Rep. 2022 05 31; 39(9):110885. Cheng Y, Medina A, Yao Z, Basu M, Natekar JP, Lang J, Sanchez E, Nkembo MB, Xu C, Qian X, Nguyen PTT, Wen Z, Song H, Ming GL, Kumar M, Brinton MA, Li MMH, Tang H. PMID: 35649379; PMCID: PMC9230077.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    8. A CRISPR Activation Screen Identifies an Atypical Rho GTPase That Enhances Zika Viral Entry. Viruses. 2021 10 20; 13(11). Luu AP, Yao Z, Ramachandran S, Azzopardi SA, Miles LA, Schneider WM, Hoffmann HH, Bozzacco L, Garcia G, Gong D, Damoiseaux R, Tang H, Morizono K, Rudin CM, Sun R, Arumugaswami V, Poirier JT, MacDonald MR, Rice CM, Li MMH. PMID: 34834920; PMCID: PMC8623001.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    9. All About the RNA: Interferon-Stimulated Genes That Interfere With Viral RNA Processes. Front Immunol. 2020; 11:605024. Yang E, Li MMH. PMID: 33362792; PMCID: PMC7756014.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    10. Hippo Signaling Pathway Has a Critical Role in Zika Virus Replication and in the Pathogenesis of Neuroinflammation. Am J Pathol. 2020 04; 190(4):844-861. Garcia G, Paul S, Beshara S, Ramanujan VK, Ramaiah A, Nielsen-Saines K, Li MMH, French SW, Morizono K, Kumar A, Arumugaswami V. PMID: 32035058; PMCID: PMC7163250.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    11. Characterization of Novel Splice Variants of Zinc Finger Antiviral Protein (ZAP). J Virol. 2019 09 15; 93(18). Li MMH, Aguilar EG, Michailidis E, Pabon J, Park P, Wu X, de Jong YP, Schneider WM, Molina H, Rice CM, MacDonald MR. PMID: 31118263; PMCID: PMC6714797.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    12. ZAP's stress granule localization is correlated with its antiviral activity and induced by virus replication. PLoS Pathog. 2019 05; 15(5):e1007798. Law LMJ, Razooky BS, Li MMH, You S, Jurado A, Rice CM, MacDonald MR. PMID: 31116799; PMCID: PMC6548403.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    13. Intrinsic Immunity Shapes Viral Resistance of Stem Cells. Cell. 2018 01 25; 172(3):423-438.e25. Wu X, Dao Thi VL, Huang Y, Billerbeck E, Saha D, Hoffmann HH, Wang Y, Silva LAV, Sarbanes S, Sun T, Andrus L, Yu Y, Quirk C, Li M, MacDonald MR, Schneider WM, An X, Rosenberg BR, Rice CM. PMID: 29249360; PMCID: PMC5786493.
      View in: PubMed   Mentions: 192     Fields:    Translation:HumansAnimalsCells
    14. TRIM25 Enhances the Antiviral Action of Zinc-Finger Antiviral Protein (ZAP). PLoS Pathog. 2017 01; 13(1):e1006145. Li MM, Lau Z, Cheung P, Aguilar EG, Schneider WM, Bozzacco L, Molina H, Buehler E, Takaoka A, Rice CM, Felsenfeld DP, MacDonald MR. PMID: 28060952; PMCID: PMC5245905.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansAnimalsCells
    15. Interferon regulatory factor 2 protects mice from lethal viral neuroinvasion. J Exp Med. 2016 12 12; 213(13):2931-2947. Li MM, Bozzacco L, Hoffmann HH, Breton G, Loschko J, Xiao JW, Monette S, Rice CM, MacDonald MR. PMID: 27899441; PMCID: PMC5154937.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    16. Sindbis Virus Can Exploit a Host Antiviral Protein To Evade Immune Surveillance. J Virol. 2016 Nov 15; 90(22):10247-10258. Wang X, Li MMH, Zhao J, Li S, MacDonald MR, Rice CM, Gao X, Gao G. PMID: 27581990; PMCID: PMC5105660.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    17. Polyamines: Small Molecules with a Big Role in Promoting Virus Infection. Cell Host Microbe. 2016 08 10; 20(2):123-4. Li MM, MacDonald MR. PMID: 27512896.
      View in: PubMed   Mentions: 13     Fields:    
    18. Chaperone-Assisted Protein Folding Is Critical for Yellow Fever Virus NS3/4A Cleavage and Replication. J Virol. 2016 Jan 06; 90(6):3212-28. Bozzacco L, Yi Z, Andreo U, Conklin CR, Li MM, Rice CM, MacDonald MR. PMID: 26739057; PMCID: PMC4810624.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    19. To translate, or not to translate: viral and host mRNA regulation by interferon-stimulated genes. Trends Cell Biol. 2015 Jun; 25(6):320-9. Li MM, MacDonald MR, Rice CM. PMID: 25748385; PMCID: PMC4441850.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    20. Prenylome profiling reveals S-farnesylation is crucial for membrane targeting and antiviral activity of ZAP long-isoform. Proc Natl Acad Sci U S A. 2013 Jul 02; 110(27):11085-90. Charron G, Li MM, MacDonald MR, Hang HC. PMID: 23776219; PMCID: PMC3703996.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    21. Multiple interferon stimulated genes synergize with the zinc finger antiviral protein to mediate anti-alphavirus activity. PLoS One. 2012; 7(5):e37398. Karki S, Li MM, Schoggins JW, Tian S, Rice CM, MacDonald MR. PMID: 22615998; PMCID: PMC3353916.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    22. Polymorphism in human APOBEC3H affects a phenotype dominant for subcellular localization and antiviral activity. J Virol. 2011 Aug; 85(16):8197-207. Li MM, Emerman M. PMID: 21653666; PMCID: PMC3147987.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    23. The range of human APOBEC3H sensitivity to lentiviral Vif proteins. J Virol. 2010 Jan; 84(1):88-95. Li MM, Wu LI, Emerman M. PMID: 19828612; PMCID: PMC2798431.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    24. Antiretroelement activity of APOBEC3H was lost twice in recent human evolution. Cell Host Microbe. 2008 Sep 11; 4(3):249-59. OhAinle M, Kerns JA, Li MM, Malik HS, Emerman M. PMID: 18779051; PMCID: PMC2608726.
      View in: PubMed   Mentions: 138     Fields:    Translation:HumansAnimalsCells
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