Roxana Radu

Title(s)Assistant Professor-in-Residence, Ophthalmology
ORCID ORCID Icon0000-0002-5064-6403 Additional info
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    Dr. Roxana A. Radu holds the Vernon O. Underwood Family Chair in Ophthalmology.

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    The Role of Complement in Recessive Stargardt Disease
    NIH R01EY025002Aug 1, 2015 - Jul 31, 2021
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. CAR-T cell therapy targeting surface expression of TYRP1 to treat cutaneous and rare melanoma subtypes. Nat Commun. 2024 Feb 09; 15(1):1244. Jilani S, Saco JD, Mugarza E, Pujol-Morcillo A, Chokry J, Ng C, Abril-Rodriguez G, Berger-Manerio D, Pant A, Hu J, Gupta R, Vega-Crespo A, Baselga-Carretero I, Chen JM, Shin DS, Scumpia P, Radu RA, Chen Y, Ribas A, Puig-Saus C. PMID: 38336975; PMCID: PMC10858182.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    2. Membrane Attack Complex Mediates Retinal Pigment Epithelium Cell Death in Stargardt Macular Degeneration. Cells. 2022 Nov 02; 11(21). Ng ESY, Kady N, Hu J, Dave A, Jiang Z, Pei J, Gorin MB, Matynia A, Radu RA. PMID: 36359858; PMCID: PMC9655712.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    3. Dawn and dusk peaks of outer segment phagocytosis, and visual cycle function require Rab28. FASEB J. 2022 05; 36(5):e22309. Moran AL, Carter SP, Kaylor JJ, Jiang Z, Broekman S, Dillon ET, Gómez Sánchez A, Minhas SK, van Wijk E, Radu RA, Travis GH, Carey M, Blacque OE, Kennedy BN. PMID: 35471581; PMCID: PMC9322422.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    4. Assessing Variant Causality and Severity Using Retinal Pigment Epithelial Cells Derived from Stargardt Disease Patients. Transl Vis Sci Technol. 2022 03 02; 11(3):33. Matynia A, Wang J, Kim S, Li Y, Dimashkie A, Jiang Z, Hu J, Strom SP, Radu RA, Chen R, Gorin MB. PMID: 35348597; PMCID: PMC8976924.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    5. Reproducibility of the Rod Photoreceptor Response Depends Critically on the Concentration of the Phosphodiesterase Effector Enzyme. J Neurosci. 2022 03 16; 42(11):2180-2189. Morshedian A, Sendek G, Ng SY, Boyd K, Radu RA, Liu M, Artemyev NO, Sampath AP, Fain GL. PMID: 35091503; PMCID: PMC8936574.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    6. Lipofuscin causes atypical necroptosis through lysosomal membrane permeabilization. Proc Natl Acad Sci U S A. 2021 11 23; 118(47). Pan C, Banerjee K, Lehmann GL, Almeida D, Hajjar KA, Benedicto I, Jiang Z, Radu RA, Thompson DH, Rodriguez-Boulan E, Nociari MM. PMID: 34782457; PMCID: PMC8617501.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    7. Evidence of complement dysregulation in outer retina of Stargardt disease donor eyes. Redox Biol. 2020 10; 37:101787. Hu J, Pauer GJ, Hagstrom SA, Bok D, DeBenedictis MJ, Bonilha VL, Hollyfield JG, Radu RA. PMID: 33214125; PMCID: PMC7767765.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    8. Geographic Atrophy: Confocal Scanning Laser Ophthalmoscopy, Histology, and Inflammation in the Region of Expanding Lesions. Invest Ophthalmol Vis Sci. 2020 07 01; 61(8):15. Bonilha VL, Bell BA, Hu J, Milliner C, Pauer GJ, Hagstrom SA, Radu RA, Hollyfield JG. PMID: 32658960; PMCID: PMC7425718.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    9. Fundus autofluorescence, spectral-domain optical coherence tomography, and histology correlations in a Stargardt disease mouse model. FASEB J. 2020 03; 34(3):3693-3714. Fang Y, Tschulakow A, Taubitz T, Illing B, Biesemeier A, Julien-Schraermeyer S, Radu RA, Jiang Z, Schraermeyer U. PMID: 31989709.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    10. LXRs regulate features of age-related macular degeneration and may be a potential therapeutic target. JCI Insight. 2020 01 16; 5(1). Choudhary M, Ismail EN, Yao PL, Tayyari F, Radu RA, Nusinowitz S, Boulton ME, Apte RS, Ruberti JW, Handa JT, Tontonoz P, Malek G. PMID: 31829999; PMCID: PMC7030875.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    11. Vitamin A Metabolism by Dendritic Cells Triggers an Antimicrobial Response against Mycobacterium tuberculosis. mSphere. 2019 06 05; 4(3). Kim EW, De Leon A, Jiang Z, Radu RA, Martineau AR, Chan ED, Bai X, Su WL, Montoya DJ, Modlin RL, Liu PT. PMID: 31167948; PMCID: PMC6553556.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    12. Light-Driven Regeneration of Cone Visual Pigments through a Mechanism Involving RGR Opsin in Müller Glial Cells. Neuron. 2019 06 19; 102(6):1172-1183.e5. Morshedian A, Kaylor JJ, Ng SY, Tsan A, Frederiksen R, Xu T, Yuan L, Sampath AP, Radu RA, Fain GL, Travis GH. PMID: 31056353; PMCID: PMC6586478.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    13. Abnormal mTORC1 signaling leads to retinal pigment epithelium degeneration. Theranostics. 2019; 9(4):1170-1180. Huang J, Gu S, Chen M, Zhang SJ, Jiang Z, Chen X, Jiang C, Liu G, Radu RA, Sun X, Vollrath D, Du J, Yan B, Zhao C. PMID: 30867823; PMCID: PMC6401408.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    14. An AAV Dual Vector Strategy Ameliorates the Stargardt Phenotype in Adult Abca4-/- Mice. Hum Gene Ther. 2019 05; 30(5):590-600. McClements ME, Barnard AR, Singh MS, Charbel Issa P, Jiang Z, Radu RA, MacLaren RE. PMID: 30381971; PMCID: PMC6909730.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    15. Expression of ABCA4 in the retinal pigment epithelium and its implications for Stargardt macular degeneration. Proc Natl Acad Sci U S A. 2018 11 20; 115(47):E11120-E11127. Lenis TL, Hu J, Ng SY, Jiang Z, Sarfare S, Lloyd MB, Esposito NJ, Samuel W, Jaworski C, Bok D, Finnemann SC, Radeke MJ, Redmond TM, Travis GH, Radu RA. PMID: 30397118; PMCID: PMC6255167.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    16. Peropsin modulates transit of vitamin A from retina to retinal pigment epithelium. J Biol Chem. 2017 12 29; 292(52):21407-21416. Cook JD, Ng SY, Lloyd M, Eddington S, Sun H, Nathans J, Bok D, Radu RA, Travis GH. PMID: 29109151; PMCID: PMC5766940.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    17. Complement modulation in the retinal pigment epithelium rescues photoreceptor degeneration in a mouse model of Stargardt disease. Proc Natl Acad Sci U S A. 2017 04 11; 114(15):3987-3992. Lenis TL, Sarfare S, Jiang Z, Lloyd MB, Bok D, Radu RA. PMID: 28348233; PMCID: PMC5393232.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    18. Monoallelic ABCA4 Mutations Appear Insufficient to Cause Retinopathy: A Quantitative Autofluorescence Study. Invest Ophthalmol Vis Sci. 2015 Dec; 56(13):8179-86. Müller PL, Gliem M, Mangold E, Bolz HJ, Finger RP, McGuinness M, Betz C, Jiang Z, Weber BH, MacLaren RE, Holz FG, Radu RA, Charbel Issa P. PMID: 26720470; PMCID: PMC5110240.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    19. Diacylglycerol O-acyltransferase type-1 synthesizes retinyl esters in the retina and retinal pigment epithelium. PLoS One. 2015; 10(5):e0125921. Kaylor JJ, Radu RA, Bischoff N, Makshanoff J, Hu J, Lloyd M, Eddington S, Bianconi T, Bok D, Travis GH. PMID: 25974161; PMCID: PMC4431840.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    20. Localization of complement factor H gene expression and protein distribution in the mouse outer retina. Mol Vis. 2015; 21:110-23. Smit-McBride Z, Oltjen SL, Radu RA, Estep J, Nguyen AT, Gong Q, Hjelmeland LM. PMID: 25684976; PMCID: PMC4323684.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    21. Cholesterol-mediated activation of acid sphingomyelinase disrupts autophagy in the retinal pigment epithelium. Mol Biol Cell. 2015 Jan 01; 26(1):1-14. Toops KA, Tan LX, Jiang Z, Radu RA, Lakkaraju A. PMID: 25378587; PMCID: PMC4279221.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    22. Beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium. Proc Natl Acad Sci U S A. 2014 Apr 08; 111(14):E1402-8. Nociari MM, Lehmann GL, Perez Bay AE, Radu RA, Jiang Z, Goicochea S, Schreiner R, Warren JD, Shan J, Adam de Beaumais S, Ménand M, Sollogoub M, Maxfield FR, Rodriguez-Boulan E. PMID: 24706818; PMCID: PMC3986126.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    23. Bisretinoid-mediated complement activation on retinal pigment epithelial cells is dependent on complement factor H haplotype. J Biol Chem. 2014 Mar 28; 289(13):9113-20. Radu RA, Hu J, Jiang Z, Bok D. PMID: 24550392; PMCID: PMC3979386.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    24. Fundus autofluorescence in the Abca4(-/-) mouse model of Stargardt disease--correlation with accumulation of A2E, retinal function, and histology. Invest Ophthalmol Vis Sci. 2013 Aug 19; 54(8):5602-12. Charbel Issa P, Barnard AR, Singh MS, Carter E, Jiang Z, Radu RA, Schraermeyer U, MacLaren RE. PMID: 23761084; PMCID: PMC3747716.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    25. Retinoid content, visual responses, and ocular morphology are compromised in the retinas of mice lacking the retinol-binding protein receptor, STRA6. Invest Ophthalmol Vis Sci. 2012 May 17; 53(6):3027-39. Ruiz A, Mark M, Jacobs H, Klopfenstein M, Hu J, Lloyd M, Habib S, Tosha C, Radu RA, Ghyselinck NB, Nusinowitz S, Bok D. PMID: 22467576; PMCID: PMC3378086.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    26. Autosomal recessive retinitis pigmentosa due to ABCA4 mutations: clinical, pathologic, and molecular characterization. Invest Ophthalmol Vis Sci. 2012 Apr 18; 53(4):1883-94. Mullins RF, Kuehn MH, Radu RA, Enriquez GS, East JS, Schindler EI, Travis GH, Stone EM. PMID: 22395892; PMCID: PMC3995570.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    27. The Usher 1B protein, MYO7A, is required for normal localization and function of the visual retinoid cycle enzyme, RPE65. Hum Mol Genet. 2011 Jul 01; 20(13):2560-70. Lopes VS, Gibbs D, Libby RT, Aleman TS, Welch DL, Lillo C, Jacobson SG, Radu RA, Steel KP, Williams DS. PMID: 21493626; PMCID: PMC3110002.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    28. Complement system dysregulation and inflammation in the retinal pigment epithelium of a mouse model for Stargardt macular degeneration. J Biol Chem. 2011 May 27; 286(21):18593-601. Radu RA, Hu J, Yuan Q, Welch DL, Makshanoff J, Lloyd M, McMullen S, Travis GH, Bok D. PMID: 21464132; PMCID: PMC3099675.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    29. Flow of energy in the outer retina in darkness and in light. Proc Natl Acad Sci U S A. 2010 May 11; 107(19):8599-604. Linton JD, Holzhausen LC, Babai N, Song H, Miyagishima KJ, Stearns GW, Lindsay K, Wei J, Chertov AO, Peters TA, Caffe R, Pluk H, Seeliger MW, Tanimoto N, Fong K, Bolton L, Kuok DL, Sweet IR, Bartoletti TM, Radu RA, Travis GH, Zagotta WN, Townes-Anderson E, Parker E, Van der Zee CE, Sampath AP, Sokolov M, Thoreson WB, Hurley JB. PMID: 20445106; PMCID: PMC2889335.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    30. The role of interphotoreceptor retinoid-binding protein on the translocation of visual retinoids and function of cone photoreceptors. J Neurosci. 2009 Feb 04; 29(5):1486-95. Jin M, Li S, Nusinowitz S, Lloyd M, Hu J, Radu RA, Bok D, Travis GH. PMID: 19193895; PMCID: PMC2680234.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    31. Accelerated accumulation of lipofuscin pigments in the RPE of a mouse model for ABCA4-mediated retinal dystrophies following Vitamin A supplementation. Invest Ophthalmol Vis Sci. 2008 Sep; 49(9):3821-9. Radu RA, Yuan Q, Hu J, Peng JH, Lloyd M, Nusinowitz S, Bok D, Travis GH. PMID: 18515570; PMCID: PMC2851626.
      View in: PubMed   Mentions: 87     Fields:    Translation:Animals
    32. Retinal pigment epithelium-retinal G protein receptor-opsin mediates light-dependent translocation of all-trans-retinyl esters for synthesis of visual chromophore in retinal pigment epithelial cells. J Biol Chem. 2008 Jul 11; 283(28):19730-8. Radu RA, Hu J, Peng J, Bok D, Mata NL, Travis GH. PMID: 18474598; PMCID: PMC2443657.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    33. A novel form of transducin-dependent retinal degeneration: accelerated retinal degeneration in the absence of rod transducin. Invest Ophthalmol Vis Sci. 2007 Dec; 48(12):5445-53. Brill E, Malanson KM, Radu RA, Boukharov NV, Wang Z, Chung HY, Lloyd MB, Bok D, Travis GH, Obin M, Lem J. PMID: 18055791; PMCID: PMC2248236.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    34. Enhanced accumulation of A2E in individuals homozygous or heterozygous for mutations in BEST1 (VMD2). Exp Eye Res. 2007 Jul; 85(1):34-43. Bakall B, Radu RA, Stanton JB, Burke JM, McKay BS, Wadelius C, Mullins RF, Stone EM, Travis GH, Marmorstein AD. PMID: 17477921.
      View in: PubMed   Mentions: 45     Fields:    Translation:Humans
    35. Characterization of native retinal fluorophores involved in biosynthesis of A2E and lipofuscin-associated retinopathies. J Biol Chem. 2006 Jun 30; 281(26):18112-9. Bui TV, Han Y, Radu RA, Travis GH, Mata NL. PMID: 16638746.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    36. Reductions in serum vitamin A arrest accumulation of toxic retinal fluorophores: a potential therapy for treatment of lipofuscin-based retinal diseases. Invest Ophthalmol Vis Sci. 2005 Dec; 46(12):4393-401. Radu RA, Han Y, Bui TV, Nusinowitz S, Bok D, Lichter J, Widder K, Travis GH, Mata NL. PMID: 16303925.
      View in: PubMed   Mentions: 99     Fields:    Translation:Animals
    37. Chicken retinas contain a retinoid isomerase activity that catalyzes the direct conversion of all-trans-retinol to 11-cis-retinol. Biochemistry. 2005 Sep 06; 44(35):11715-21. Mata NL, Ruiz A, Radu RA, Bui TV, Travis GH. PMID: 16128572; PMCID: PMC2851629.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    38. Light exposure stimulates formation of A2E oxiranes in a mouse model of Stargardt's macular degeneration. Proc Natl Acad Sci U S A. 2004 Apr 20; 101(16):5928-33. Radu RA, Mata NL, Bagla A, Travis GH. PMID: 15067110; PMCID: PMC395900.
      View in: PubMed   Mentions: 73     Fields:    Translation:Animals
    39. Isotretinoin treatment inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration. Novartis Found Symp. 2004; 255:51-63; discussion 63-7, 177-8. Radu RA, Mata NL, Nusinowitz S, Liu X, Travis GH. PMID: 14750596.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    40. Rpe65 is a retinyl ester binding protein that presents insoluble substrate to the isomerase in retinal pigment epithelial cells. J Biol Chem. 2004 Jan 02; 279(1):635-43. Mata NL, Moghrabi WN, Lee JS, Bui TV, Radu RA, Horwitz J, Travis GH. PMID: 14532273.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    41. Treatment with isotretinoin inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration. Proc Natl Acad Sci U S A. 2003 Apr 15; 100(8):4742-7. Radu RA, Mata NL, Nusinowitz S, Liu X, Sieving PA, Travis GH. PMID: 12671074; PMCID: PMC153626.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansAnimalsCells
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