Hui Sun

Title(s)Professor, Physiology
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    Title(s)Professor, Ophthalmology

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    Collapse Awards and Honors
    Howard Hughes Medical Institute2009  - 2015Howard Hughes Medical Institute Early Career Scientist Award
    Ellison Medical Foundation2006  - 2010Ellison Medical Foundation New Scholar Award
    E. Matilda Ziegler Foundation2005  - 2008E. Matilda Ziegler Foundation Award
    UCLA2005  - 2005Gerald Oppenheimer Family Foundation Award
    Ruth and Milton Steinbach Foundation2004  - 2007Ruth and Milton Steinbach Award
    UCLA2004  - 2004Stein-Oppenheimer Endowment Award
    Karl Kirchgessner Foundation2003  - 2003Karl Kirchgessner Foundation Award
    Johns Hopkins University1998  - 1998Alicia Showalter Reynolds Research Prize

    Collapse Overview 
    Collapse Overview
    Dr. Sun's lab has focused on the discovery, mechanistic study and identifying small molecule modulators of novel membrane receptors that play important roles in physiology and diseases. To achieve these goals, several new techniques have been developed by his lab. The first major discovery is the membrane receptor that mediates cellular uptake of vitamin A, a chemical essential for human survival. This receptor is expressed in blood-organ barriers and eluded identification for more than 30 years. Another discovery is the signaling receptor for the most potent endogenous inhibitor of angiogenesis. This receptor is highly specifically expressed in pathogenic blood vessels including tumor blood vessels. By developing a novel fluorescence-based technique, his team and collaborators identified potent chemical compounds that target this receptor to specifically kill tumor blood vessels to lead to effective tumor killing in vivo. In the past few years, his lab also developed a novel technique to screen for receptor-activating antibodies and successfully identified antibody drug candidates of this receptor after large-scale screening 10 billion human antibody clones in collaboration with scientists within and outside of UCLA.

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Regulatory mechanism for the transmembrane receptor that mediates bidirectional vitamin A transport. Proc Natl Acad Sci U S A. 2020 05 05; 117(18):9857-9864. Zhong M, Kawaguchi R, Costabile B, Tang Y, Hu J, Cheng G, Kassai M, Ribalet B, Mancia F, Bok D, Sun H. PMID: 32300017; PMCID: PMC7211970.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    2. Peropsin modulates transit of vitamin A from retina to retinal pigment epithelium. J Biol Chem. 2017 12 29; 292(52):21407-21416. Cook JD, Ng SY, Lloyd M, Eddington S, Sun H, Nathans J, Bok D, Radu RA, Travis GH. PMID: 29109151; PMCID: PMC5766940.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    3. Vitamin A Transport Mechanism of the Multitransmembrane Cell-Surface Receptor STRA6. Membranes (Basel). 2015 Aug 28; 5(3):425-53. Kawaguchi R, Zhong M, Kassai M, Ter-Stepanian M, Sun H. PMID: 26343735; PMCID: PMC4584289.
      View in: PubMed   Mentions: 31  
    4. A genetic clog in the vitamin A transport machinery. Cell. 2015 Apr 23; 161(3):435-437. Zhong M, Sun H. PMID: 25910203.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    5. Identification of PLXDC1 and PLXDC2 as the transmembrane receptors for the multifunctional factor PEDF. Elife. 2014 Dec 23; 3:e05401. Cheng G, Zhong M, Kawaguchi R, Kassai M, Al-Ubaidi M, Deng J, Ter-Stepanian M, Sun H. PMID: 25535841; PMCID: PMC4303762.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    6. Real-time analyses of retinol transport by the membrane receptor of plasma retinol binding protein. J Vis Exp. 2013 Jan 28; (71):e50169. Kawaguchi R, Zhong M, Sun H. PMID: 23407361; PMCID: PMC3582664.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    7. STRA6-catalyzed vitamin A influx, efflux, and exchange. J Membr Biol. 2012 Nov; 245(11):731-45. Kawaguchi R, Zhong M, Kassai M, Ter-Stepanian M, Sun H. PMID: 22815070; PMCID: PMC3770467.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    8. Receptor-mediated cellular uptake mechanism that couples to intracellular storage. ACS Chem Biol. 2011 Oct 21; 6(10):1041-51. Kawaguchi R, Yu J, Ter-Stepanian M, Zhong M, Cheng G, Yuan Q, Jin M, Travis GH, Ong D, Sun H. PMID: 21774515; PMCID: PMC3199320.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    9. Techniques to study specific cell-surface receptor-mediated cellular vitamin A uptake. Methods Mol Biol. 2010; 652:341-61. Kawaguchi R, Sun H. PMID: 20552439; PMCID: PMC3907174.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    10. An essential ligand-binding domain in the membrane receptor for retinol-binding protein revealed by large-scale mutagenesis and a human polymorphism. J Biol Chem. 2008 May 30; 283(22):15160-8. Kawaguchi R, Yu J, Wiita P, Honda J, Sun H. PMID: 18387951; PMCID: PMC2397481.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    11. Biochemical analysis of a common human polymorphism associated with age-related macular degeneration. Biochemistry. 2007 Jul 17; 46(28):8451-61. Yu J, Wiita P, Kawaguchi R, Honda J, Jorgensen A, Zhang K, Fischetti VA, Sun H. PMID: 17580967.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    12. A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A. Science. 2007 Feb 09; 315(5813):820-5. Kawaguchi R, Yu J, Honda J, Hu J, Whitelegge J, Ping P, Wiita P, Bok D, Sun H. PMID: 17255476.
      View in: PubMed   Mentions: 353     Fields:    Translation:HumansAnimalsCells
    13. A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration. Science. 2006 Nov 10; 314(5801):992-3. Yang Z, Camp NJ, Sun H, Tong Z, Gibbs D, Cameron DJ, Chen H, Zhao Y, Pearson E, Li X, Chien J, Dewan A, Harmon J, Bernstein PS, Shridhar V, Zabriskie NA, Hoh J, Howes K, Zhang K. PMID: 17053109.
      View in: PubMed   Mentions: 323     Fields:    Translation:HumansCells
    14. Rpe65 is the retinoid isomerase in bovine retinal pigment epithelium. Cell. 2005 Aug 12; 122(3):449-59. Jin M, Li S, Moghrabi WN, Sun H, Travis GH. PMID: 16096063; PMCID: PMC2748856.
      View in: PubMed   Mentions: 226     Fields:    Translation:HumansAnimalsCells
    15. Structure-function analysis of the bestrophin family of anion channels. J Biol Chem. 2003 Oct 17; 278(42):41114-25. Tsunenari T, Sun H, Williams J, Cahill H, Smallwood P, Yau KW, Nathans J. PMID: 12907679; PMCID: PMC2885917.
      View in: PubMed   Mentions: 113     Fields:    Translation:HumansAnimalsCells
    16. The vitelliform macular dystrophy protein defines a new family of chloride channels. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):4008-13. Sun H, Tsunenari T, Yau KW, Nathans J. PMID: 11904445; PMCID: PMC122639.
      View in: PubMed   Mentions: 203     Fields:    Translation:HumansAnimalsCells
    17. The challenge of macular degeneration. Sci Am. 2001 Oct; 285(4):68-75. Sun H, Nathans J. PMID: 11570044.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    18. Biochemical defects in ABCR protein variants associated with human retinopathies. Nat Genet. 2000 Oct; 26(2):242-6. Sun H, Smallwood PM, Nathans J. PMID: 11017087.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansCells
    19. Retinal stimulates ATP hydrolysis by purified and reconstituted ABCR, the photoreceptor-specific ATP-binding cassette transporter responsible for Stargardt disease. J Biol Chem. 1999 Mar 19; 274(12):8269-81. Sun H, Molday RS, Nathans J. PMID: 10075733.
      View in: PubMed   Mentions: 130     Fields:    Translation:AnimalsCells
    20. Crx, a novel Otx-like paired-homeodomain protein, binds to and transactivates photoreceptor cell-specific genes. Neuron. 1997 Nov; 19(5):1017-30. Chen S, Wang QL, Nie Z, Sun H, Lennon G, Copeland NG, Gilbert DJ, Jenkins NA, Zack DJ. PMID: 9390516.
      View in: PubMed   Mentions: 247     Fields:    Translation:HumansAnimalsCells
    21. Mechanisms of spectral tuning in the mouse green cone pigment. Proc Natl Acad Sci U S A. 1997 Aug 05; 94(16):8860-5. Sun H, Macke JP, Nathans J. PMID: 9238068; PMCID: PMC23167.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    22. A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy. Nat Genet. 1997 Mar; 15(3):236-46. Allikmets R, Singh N, Sun H, Shroyer NF, Hutchinson A, Chidambaram A, Gerrard B, Baird L, Stauffer D, Peiffer A, Rattner A, Smallwood P, Li Y, Anderson KL, Lewis RA, Nathans J, Leppert M, Dean M, Lupski JR. PMID: 9054934.
      View in: PubMed   Mentions: 478     Fields:    Translation:HumansAnimalsCells
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