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Gabriel H Travis

Title(s)Professor, Ophthalmology
SchoolMedicine
Address760 Westwood Plaza 2-132
Los Angeles CA 90024
Phone72673
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    Other Positions
    Title(s)Professor, Biological Chemistry


    Collapse Research 
    Collapse Research Activities and Funding
    Mechanisms for Light-driven Chromophore Synthesis by Müller Cells to Regenerate Cone Opsin and Maintain Cone Sensitivity
    NIH R01EY024379Sep 1, 2015 - Dec 31, 2024
    Role: Principal Investigator
    Biochemical and Genetic Analysis of the Visual Cycle
    NIH R01EY015844Sep 9, 2005 - Jul 31, 2011
    Role: Principal Investigator
    The Role of Muller Cells in Visual Pigment Regeneration
    NIH R01EY011713Mar 1, 1997 - Jun 30, 2018
    Role: Principal Investigator
    FUNCTION /INTERACTION OF RDS/PERIPHERIN IN PHOTORECEPTOR
    NIH R01EY008043May 1, 1989 - Aug 31, 1989
    Role: Principal Investigator
    MOLECULAR CHARACTERIZATION OF THE HIPPOCAMPUS &CEREBRUM
    NIH K08NS000918Aug 1, 1985 - Jul 31, 1990
    Role: Principal Investigator
    Vision Science Training Program
    NIH T32EY007026Jul 1, 1975 - Sep 29, 2016
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Rod photoreceptors avoid saturation in bright light by the movement of the G protein transducin. J Neurosci. 2021 Feb 15. Frederiksen R, Morshedian A, Tripathy SA, Xu T, Travis GH, Fain GL, Sampath AP. PMID: 33593858.
      View in: PubMed   Mentions:    Fields:    
    2. Light-Driven Regeneration of Cone Visual Pigments through a Mechanism Involving RGR Opsin in Müller Glial Cells. Neuron. 2019 06 19; 102(6):1172-1183.e5. Morshedian A, Kaylor JJ, Ng SY, Tsan A, Frederiksen R, Xu T, Yuan L, Sampath AP, Radu RA, Fain GL, Travis GH. PMID: 31056353.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    3. Expression of ABCA4 in the retinal pigment epithelium and its implications for Stargardt macular degeneration. Proc Natl Acad Sci U S A. 2018 11 20; 115(47):E11120-E11127. Lenis TL, Hu J, Ng SY, Jiang Z, Sarfare S, Lloyd MB, Esposito NJ, Samuel W, Jaworski C, Bok D, Finnemann SC, Radeke MJ, Redmond TM, Travis GH, Radu RA. PMID: 30397118.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    4. Peropsin modulates transit of vitamin A from retina to retinal pigment epithelium. J Biol Chem. 2017 12 29; 292(52):21407-21416. Cook JD, Ng SY, Lloyd M, Eddington S, Sun H, Nathans J, Bok D, Radu RA, Travis GH. PMID: 29109151.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    5. Blue light regenerates functional visual pigments in mammals through a retinyl-phospholipid intermediate. Nat Commun. 2017 05 04; 8(1):16. Kaylor JJ, Xu T, Ingram NT, Tsan A, Hakobyan H, Fain GL, Travis GH. PMID: 28473692.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    6. Receptor interacting protein kinase-mediated necrosis contributes to cone and rod photoreceptor degeneration in the retina lacking interphotoreceptor retinoid-binding protein. J Neurosci. 2013 Oct 30; 33(44):17458-68. Sato K, Li S, Gordon WC, He J, Liou GI, Hill JM, Travis GH, Bazan NG, Jin M. PMID: 24174679.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    7. Identification of DES1 as a vitamin A isomerase in Müller glial cells of the retina. Nat Chem Biol. 2013 Jan; 9(1):30-6. Kaylor JJ, Yuan Q, Cook J, Sarfare S, Makshanoff J, Miu A, Kim A, Kim P, Habib S, Roybal CN, Xu T, Nusinowitz S, Travis GH. PMID: 23143414.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    8. Complement system dysregulation and inflammation in the retinal pigment epithelium of a mouse model for Stargardt macular degeneration. J Biol Chem. 2011 May 27; 286(21):18593-601. Radu RA, Hu J, Yuan Q, Welch DL, Makshanoff J, Lloyd M, McMullen S, Travis GH, Bok D. PMID: 21464132.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    9. Molecular signature of primary retinal pigment epithelium and stem-cell-derived RPE cells. Hum Mol Genet. 2010 Nov 01; 19(21):4229-38. Liao JL, Yu J, Huang K, Hu J, Diemer T, Ma Z, Dvash T, Yang XJ, Travis GH, Williams DS, Bok D, Fan G. PMID: 20709808.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansCells
    10. Analysis of the retinoid isomerase activities in the retinal pigment epithelium and retina. Methods Mol Biol. 2010; 652:329-39. Travis GH, Kaylor J, Yuan Q. PMID: 20552438.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    11. Rpe65 isomerase associates with membranes through an electrostatic interaction with acidic phospholipid headgroups. J Biol Chem. 2010 Jan 08; 285(2):988-99. Yuan Q, Kaylor JJ, Miu A, Bassilian S, Whitelegge JP, Travis GH. PMID: 19892706.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    12. Accelerated accumulation of lipofuscin pigments in the RPE of a mouse model for ABCA4-mediated retinal dystrophies following Vitamin A supplementation. Invest Ophthalmol Vis Sci. 2008 Sep; 49(9):3821-9. Radu RA, Yuan Q, Hu J, Peng JH, Lloyd M, Nusinowitz S, Bok D, Travis GH. PMID: 18515570.
      View in: PubMed   Mentions: 68     Fields:    Translation:Animals
    13. Role of LRAT on the retinoid isomerase activity and membrane association of Rpe65. J Biol Chem. 2007 Jul 20; 282(29):20915-24. Jin M, Yuan Q, Li S, Travis GH. PMID: 17504753.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    14. Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents. Annu Rev Pharmacol Toxicol. 2007; 47:469-512. Travis GH, Golczak M, Moise AR, Palczewski K. PMID: 16968212.
      View in: PubMed   Mentions: 204     Fields:    Translation:HumansAnimalsCells
    15. Characterization of native retinal fluorophores involved in biosynthesis of A2E and lipofuscin-associated retinopathies. J Biol Chem. 2006 Jun 30; 281(26):18112-9. Bui TV, Han Y, Radu RA, Travis GH, Mata NL. PMID: 16638746.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    16. Reductions in serum vitamin A arrest accumulation of toxic retinal fluorophores: a potential therapy for treatment of lipofuscin-based retinal diseases. Invest Ophthalmol Vis Sci. 2005 Dec; 46(12):4393-401. Radu RA, Han Y, Bui TV, Nusinowitz S, Bok D, Lichter J, Widder K, Travis GH, Mata NL. PMID: 16303925.
      View in: PubMed   Mentions: 75     Fields:    Translation:Animals
    17. Rpe65 is the retinoid isomerase in bovine retinal pigment epithelium. Cell. 2005 Aug 12; 122(3):449-59. Jin M, Li S, Moghrabi WN, Sun H, Travis GH. PMID: 16096063.
      View in: PubMed   Mentions: 196     Fields:    Translation:HumansAnimalsCells
    18. Acyl CoA:retinol acyltransferase (ARAT) activity is present in bovine retinal pigment epithelium. Exp Eye Res. 2006 Jan; 82(1):111-21. Kaschula CH, Jin MH, Desmond-Smith NS, Travis GH. PMID: 16054134.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    19. DISCO! Dissociation of cone opsins: the fast and noisy life of cones explained. Neuron. 2005 Jun 16; 46(6):840-2. Travis GH. PMID: 15953411.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    20. Light exposure stimulates formation of A2E oxiranes in a mouse model of Stargardt's macular degeneration. Proc Natl Acad Sci U S A. 2004 Apr 20; 101(16):5928-33. Radu RA, Mata NL, Bagla A, Travis GH. PMID: 15067110.
      View in: PubMed   Mentions: 58     Fields:    Translation:Animals
    21. Isotretinoin treatment inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration. Novartis Found Symp. 2004; 255:51-63; discussion 63-7, 177-8. Radu RA, Mata NL, Nusinowitz S, Liu X, Travis GH. PMID: 14750596.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    22. Rpe65 is a retinyl ester binding protein that presents insoluble substrate to the isomerase in retinal pigment epithelial cells. J Biol Chem. 2004 Jan 02; 279(1):635-43. Mata NL, Moghrabi WN, Lee JS, Bui TV, Radu RA, Horwitz J, Travis GH. PMID: 14532273.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    23. Treatment with isotretinoin inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration. Proc Natl Acad Sci U S A. 2003 Apr 15; 100(8):4742-7. Radu RA, Mata NL, Nusinowitz S, Liu X, Sieving PA, Travis GH. PMID: 12671074.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    24. Isomerization and oxidation of vitamin a in cone-dominant retinas: a novel pathway for visual-pigment regeneration in daylight. Neuron. 2002 Sep 26; 36(1):69-80. Mata NL, Radu RA, Clemmons RC, Travis GH. PMID: 12367507.
      View in: PubMed   Mentions: 146     Fields:    Translation:AnimalsCells
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