Xianjie Yang

Title(s)Professor-in-Residence, Ophthalmology
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    Collapse Education and Training
    Harvard Medical School , Boston, Mass, USAPostdoc1995Molecular Neuroscience
    Harvard University, Cambridge, Mass, USAPostdoc1989Developmental Biology
    Cornell University, Ithaca, New York, USPhD1988Biochemistry, Cell and Molecular Biology
    Peking Normal University, Beijing, ChinaBS1981Biology
    Collapse Awards and Honors
    Helen Hay Whitney Foundation1988  - 1991Postdoctoral Fellowship
    Medical Foundation/King Turst1991  - 1992Postdoctoral Fellowship
    NIH1992  - 1994Postdoctoral Fellowship
    Foundation Fighting Blindness1996  - 2000Career Development Award
    March of Dimes Foundation1998  - 2000Basil O'Connor Starter Award
    Karl Kirchgessner Foundation1999  - 2002Research Awards
    Foundation Fighting Blindness2002  - 2003Dolly Green Special Scholar Award
    University of California Los Angeles2012Ernest G. Herman Chair in Ophthalmology
    University of California Los Angeles2022Undergraduate Mentor Award

    Collapse Overview 
    Collapse Overview
    Dr. Xian-Jie Yang is a molecular biologist whose research interests are the development and repair of the neural retina. The Yang laboratory uses broad research approaches including genetically engineered mice and viral vector-mediated gene delivery to study regulatory mechanisms involved in retinal progenitor proliferation and differentiation. In NIH funded research, the Yang laboratory has investigated cellular mechanism and signaling pathways impact retinal neuron survival using genetic models in conjunction with molecular and biochemical analyses. A primary focus is on retinal metabolism during development, degeneration, and regeneration. In recent years, the Yang laboratory has also successfully derived induced pluripotent stem cells (iPSCs), established 3D retinal organoid cultures from human pluripotent stem cells, and developed methods to enhance retinal ganglion cell production. Current research funded by the California Institute of Regenerative Medicine (CIRM) aims at developing a gene therapy for dominant optic atrophy using stem cell-based disease models.

    Complete List of Published Work in MyBibliography:

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Ciliary neurotrophic factor-mediated neuroprotection involves enhanced glycolysis and anabolism in degenerating mouse retinas. Nat Commun. 2022 11 17; 13(1):7037. Do Rhee K, Wang Y, Ten Hoeve J, Stiles L, Nguyen TTT, Zhang X, Vergnes L, Reue K, Shirihai O, Bok D, Yang XJ. PMID: 36396639; PMCID: PMC9672129.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    2. Single Cell Transcriptomic Analyses Reveal the Impact of bHLH Factors on Human Retinal Organoid Development. Front Cell Dev Biol. 2021; 9:653305. Zhang X, Mandric I, Nguyen KH, Nguyen TTT, Pellegrini M, Grove JCR, Barnes S, Yang XJ. PMID: 34055784; PMCID: PMC8155690.
      View in: PubMed   Mentions: 6  
    3. Generation of a homozygous LRP2 knockout human embryonic stem cell line (FDCHDPe010-A-56) by CRISPR/Cas9 system. Stem Cell Res. 2021 05; 53:102342. You J, Cheng Y, Yang XJ, Chen L. PMID: 33878707; PMCID: PMC9303849.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Impacts of ciliary neurotrophic factor on the retinal transcriptome in a mouse model of photoreceptor degeneration. Sci Rep. 2020 04 20; 10(1):6593. Wang Y, Rhee KD, Pellegrini M, Yang XJ. PMID: 32313077; PMCID: PMC7171121.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    5. Single-Cell RNA Sequencing of hESC-Derived 3D Retinal Organoids Reveals Novel Genes Regulating RPC Commitment in Early Human Retinogenesis. Stem Cell Reports. 2019 10 08; 13(4):747-760. Mao X, An Q, Xi H, Yang XJ, Zhang X, Yuan S, Wang J, Hu Y, Liu Q, Fan G. PMID: 31543471; PMCID: PMC6829752.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    6. Generation of an integration-free induced pluripotent stem cell line (FDEENTi003-A) from a patient with pathological myopia. Stem Cell Res. 2019 08; 39:101495. Bai X, Yang XJ, Chen L. PMID: 31376721; PMCID: PMC7077977.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    7. Establishment of an induced pluripotent stem cell line (FDEENTi002-A) from a patient with Best's disease carrying c.888C > A mutation in BEST1 gene. Stem Cell Res. 2019 07; 38:101459. Bai X, Yang XJ, Chen L. PMID: 31146250; PMCID: PMC7156156.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    8. Establishment of an induced pluripotent stem cell line (FDEENTi001-A) from a patient with pathological myopia. Stem Cell Res. 2019 01; 34:101369. Bai X, Yang X, Cheng Y, Chen L. PMID: 30611020; PMCID: PMC6441353.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    9. Elevated expression of human bHLH factor ATOH7 accelerates cell cycle progression of progenitors and enhances production of avian retinal ganglion cells. Sci Rep. 2018 05 01; 8(1):6823. Zhang XM, Hashimoto T, Tang R, Yang XJ. PMID: 29717171; PMCID: PMC5931526.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    10. Müller glial cell-dependent regeneration of the neural retina: An overview across vertebrate model systems. Dev Dyn. 2016 07; 245(7):727-38. Hamon A, Roger JE, Yang XJ, Perron M. PMID: 26661417; PMCID: PMC4900950.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    11. AAV-mediated and pharmacological induction of Hsp70 expression stimulates survival of retinal ganglion cells following axonal injury. Gene Ther. 2015 Feb; 22(2):138-45. Kwong JM, Gu L, Nassiri N, Bekerman V, Kumar-Singh R, Rhee KD, Yang XJ, Hauswirth WW, Caprioli J, Piri N. PMID: 25427613; PMCID: PMC4320032.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    12. Differentiation of retinal ganglion cells and photoreceptor precursors from mouse induced pluripotent stem cells carrying an Atoh7/Math5 lineage reporter. PLoS One. 2014; 9(11):e112175. Xie BB, Zhang XM, Hashimoto T, Tien AH, Chen A, Ge J, Yang XJ. PMID: 25401462; PMCID: PMC4234374.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    13. CNTF-mediated protection of photoreceptors requires initial activation of the cytokine receptor gp130 in Müller glial cells. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):E4520-9. Rhee KD, Nusinowitz S, Chao K, Yu F, Bok D, Yang XJ. PMID: 24191003; PMCID: PMC3839707.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    14. Dnmt1-dependent DNA methylation is essential for photoreceptor terminal differentiation and retinal neuron survival. Cell Death Dis. 2012 Nov 22; 3:e427. Rhee KD, Yu J, Zhao CY, Fan G, Yang XJ. PMID: 23171847; PMCID: PMC3542601.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    15. Transfection of primary embryonic chicken retinal cells using cationic lipid. Methods Mol Biol. 2012; 884:183-92. Hsieh YW, Yang XJ. PMID: 22688706; PMCID: PMC6472892.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    16. PTEN regulates retinal interneuron morphogenesis and synaptic layer formation. Mol Cell Neurosci. 2012 Feb; 49(2):171-83. Sakagami K, Chen B, Nusinowitz S, Wu H, Yang XJ. PMID: 22155156; PMCID: PMC3278565.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    17. Molecular signature of primary retinal pigment epithelium and stem-cell-derived RPE cells. Hum Mol Genet. 2010 Nov 01; 19(21):4229-38. Liao JL, Yu J, Huang K, Hu J, Diemer T, Ma Z, Dvash T, Yang XJ, Travis GH, Williams DS, Bok D, Fan G. PMID: 20709808; PMCID: PMC3115666.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansCells
    18. Function and mechanism of CNTF/LIF signaling in retinogenesis. Adv Exp Med Biol. 2010; 664:647-54. Rhee KD, Yang XJ. PMID: 20238069; PMCID: PMC3234160.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    19. Dynamic Pax6 expression during the neurogenic cell cycle influences proliferation and cell fate choices of retinal progenitors. Neural Dev. 2009 Aug 17; 4:32. Hsieh YW, Yang XJ. PMID: 19686589; PMCID: PMC2741438.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    20. Distinct effects of Hedgehog signaling on neuronal fate specification and cell cycle progression in the embryonic mouse retina. J Neurosci. 2009 May 27; 29(21):6932-44. Sakagami K, Gan L, Yang XJ. PMID: 19474320; PMCID: PMC2715855.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    21. Role of the immune modulator programmed cell death-1 during development and apoptosis of mouse retinal ganglion cells. Invest Ophthalmol Vis Sci. 2009 Oct; 50(10):4941-8. Chen L, Sham CW, Chan AM, Francisco LM, Wu Y, Mareninov S, Sharpe AH, Freeman GJ, Yang XJ, Braun J, Gordon LK. PMID: 19420345; PMCID: PMC3222380.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    22. Molecular and cellular alterations induced by sustained expression of ciliary neurotrophic factor in a mouse model of retinitis pigmentosa. Invest Ophthalmol Vis Sci. 2007 Mar; 48(3):1389-400. Rhee KD, Ruiz A, Duncan JL, Hauswirth WW, Lavail MM, Bok D, Yang XJ. PMID: 17325188; PMCID: PMC7147570.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    23. Lentiviral gene replacement therapy of retinas in a mouse model for Usher syndrome type 1B. Gene Ther. 2007 Apr; 14(7):584-94. Hashimoto T, Gibbs D, Lillo C, Azarian SM, Legacki E, Zhang XM, Yang XJ, Williams DS. PMID: 17268537; PMCID: PMC9307148.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    24. VEGF activates divergent intracellular signaling components to regulate retinal progenitor cell proliferation and neuronal differentiation. Development. 2006 Jun; 133(11):2201-10. Hashimoto T, Zhang XM, Chen BY, Yang XJ. PMID: 16672338; PMCID: PMC7060787.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    25. Cytokine-induced activation of signal transducer and activator of transcription in photoreceptor precursors regulates rod differentiation in the developing mouse retina. J Neurosci. 2004 Nov 03; 24(44):9779-88. Rhee KD, Goureau O, Chen S, Yang XJ. PMID: 15525763; PMCID: PMC6730236.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    26. Roles of cell-extrinsic growth factors in vertebrate eye pattern formation and retinogenesis. Semin Cell Dev Biol. 2004 Feb; 15(1):91-103. Yang XJ. PMID: 15036212; PMCID: PMC7048382.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    27. Ciliary neurotrophic factor promotes muller glia differentiation from the postnatal retinal progenitor pool. Dev Neurosci. 2004; 26(5-6):359-70. Goureau O, Rhee KD, Yang XJ. PMID: 15855765; PMCID: PMC7050730.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    28. Expression of cytokine signal transduction components in the postnatal mouse retina. Mol Vis. 2003 Dec 16; 9:715-22. Rhee KD, Yang XJ. PMID: 14685141; PMCID: PMC7048383.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    29. Elovl4 mRNA distribution in the developing mouse retina and phylogenetic conservation of Elovl4 genes. Mol Vis. 2003 Jul 03; 9:301-7. Zhang XM, Yang Z, Karan G, Hashimoto T, Baehr W, Yang XJ, Zhang K. PMID: 12847421; PMCID: PMC7048384.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    30. Expression of the Flk1 receptor and its ligand VEGF in the developing chick central nervous system. Gene Expr Patterns. 2003 Mar; 3(1):109-13. Hashimoto T, Zhang XM, Yang XJ. PMID: 12609612; PMCID: PMC7048375.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    31. Retrovirus-mediated gene expression during chick visual system development. Methods. 2002 Dec; 28(4):396-401. Yang XJ. PMID: 12507457; PMCID: PMC7048385.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    32. The homeobox gene Six3 is a potential regulator of anterior segment formation in the chick eye. Dev Biol. 2002 Aug 15; 248(2):265-80. Hsieh YW, Zhang XM, Lin E, Oliver G, Yang XJ. PMID: 12167403; PMCID: PMC7048386.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    33. Temporal and spatial effects of Sonic hedgehog signaling in chick eye morphogenesis. Dev Biol. 2001 May 15; 233(2):271-90. Zhang XM, Yang XJ. PMID: 11336495; PMCID: PMC7048387.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    34. Regulation of retinal ganglion cell production by Sonic hedgehog. Development. 2001 Mar; 128(6):943-57. Zhang XM, Yang XJ. PMID: 11222148; PMCID: PMC7048390.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    35. In situ hybridization. Methods Mol Med. 2001; 47:45-69. Yang XJ. PMID: 21394578.
      View in: PubMed   Mentions: 2     Fields:    
    36. Preparation of recombinant retroviruses. Methods Mol Med. 2001; 47:171-90. Yang XJ. PMID: 21394585.
      View in: PubMed   Mentions: 2     Fields:    
    37. Increased expression of osteonectin/SPARC mRNA and protein in age-related human cataracts and spatial expression in the normal human lens. Mol Vis. 2000 Apr 05; 6:24-9. Kantorow M, Huang Q, Yang XJ, Sage EH, Magabo KS, Miller KM, Horwitz J. PMID: 10756178; PMCID: PMC2831409.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    38. Sonic hedgehog-mediated ventralization disrupts formation of the midbrain-hindbrain junction in the chick embryo. Dev Neurosci. 2000; 22(3):207-16. Zhang XM, Lin E, Yang XJ. PMID: 10894984.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    39. Postmitotic cells fated to become rod photoreceptors can be respecified by CNTF treatment of the retina. Development. 1997 Mar; 124(5):1055-67. Ezzeddine ZD, Yang X, DeChiara T, Yancopoulos G, Cepko CL. PMID: 9056780.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    40. Flk-1, a receptor for vascular endothelial growth factor (VEGF), is expressed by retinal progenitor cells. J Neurosci. 1996 Oct 01; 16(19):6089-99. Yang X, Cepko CL. PMID: 8815891; PMCID: PMC6579183.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    41. Cell fate determination in the vertebrate retina. Proc Natl Acad Sci U S A. 1996 Jan 23; 93(2):589-95. Cepko CL, Austin CP, Yang X, Alexiades M, Ezzeddine D. PMID: 8570600; PMCID: PMC40096.
      View in: PubMed   Mentions: 346     Fields:    Translation:AnimalsCells
    42. Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase. Cell. 1993 Jul 30; 74(2):237-44. Argetsinger LS, Campbell GS, Yang X, Witthuhn BA, Silvennoinen O, Ihle JN, Carter-Su C. PMID: 8343952.
      View in: PubMed   Mentions: 192     Fields:    Translation:AnimalsCells
    43. Molecular cloning of the murine JAK1 protein tyrosine kinase and its expression in the mouse central nervous system. J Neurosci. 1993 Jul; 13(7):3006-17. Yang X, Chung D, Cepko CL. PMID: 8331382; PMCID: PMC6576690.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    44. Specificity and mechanism of antitermination by Q proteins of bacteriophages lambda and 82. J Mol Biol. 1989 Dec 05; 210(3):453-60. Yang XJ, Goliger JA, Roberts JW. PMID: 2559206.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    45. Gene Q antiterminator proteins of Escherichia coli phages 82 and lambda suppress pausing by RNA polymerase at a rho-dependent terminator and at other sites. Proc Natl Acad Sci U S A. 1989 Jul; 86(14):5301-5. Yang XJ, Roberts JW. PMID: 2526335; PMCID: PMC297609.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    46. Early transcribed sequences affect termination efficiency of Escherichia coli RNA polymerase. J Mol Biol. 1989 Jan 20; 205(2):331-41. Goliger JA, Yang XJ, Guo HC, Roberts JW. PMID: 2467004.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    47. Transcription antitermination by phage lambda gene Q protein requires a DNA segment spanning the RNA start site. Genes Dev. 1987 May; 1(3):217-26. Yang XJ, Hart CM, Grayhack EJ, Roberts JW. PMID: 2960589.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    48. Phage lambda gene Q antiterminator recognizes RNA polymerase near the promoter and accelerates it through a pause site. Cell. 1985 Aug; 42(1):259-69. Grayhack EJ, Yang XJ, Lau LF, Roberts JW. PMID: 2990726.
      View in: PubMed   Mentions: 58     Fields:    Translation:Cells
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