Jaydutt V Vadgama

Title(s)Professor-in-Residence, Medicine
SchoolMedicine
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    Collapse Biography 
    Collapse Education and Training
    University of East London, London, EnglandB.Sc.1975Biochemistry/Physiology
    University of London, Chelsea College, London, EnglandPh.D. 1981Biochemistry
    University of Michigan, Ann Arbor, MIPost-doctoral FellowshipBiological Chemistry

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    Collapse Overview
    Dr. Vadgama is the Vice President for Research and Health Affairs at Charles R. Drew University of Medicine and Science (CDU). He is a Full Professor of Medicine at CDU and the UCLA David Geffen School of Medicine in the Department(s) of Internal Medicine. Dr. Vadgama has provided significant leadership in growing and sustaining research at CDU over the last two decades. Dr. Vadgama has several additional administrative responsibilities that include Chair of the Institutional Space Committee, Chair of the Ph.D. Planning Committee, establishing the Intellectual Property/Patent Committee at CDU, Institutional Official for IACUC, and chairing several Task Force committees.
    Leadership Experience: Dr. Vadgama continues to serve as Division Chief, Center Director, Vice President, member of the President’s Executive Team, and the Provost’s Team in addition to several additional executive roles. He has over 30 years of direct experience in Academia and Research with a strong understanding of the processes, policies, and procedures necessary to attain academic excellence. He provides significant support and leadership to students, faculty, the Academic Senate, division chiefs, department chairs, deans, provosts, and the University president on matters relevant to research, academic processes, challenges, and growth. Under Dr. Vadgama’s leadership, CDU has set the foundation for establishing a Precision Medicine program's infrastructure to bring genomic-level diagnosis to the translational investigation. He continues to work with faculty, students, and staff to strengthen clinical, basic, and translational research/programs, integrate them with academic programs across campus and develop strong partnerships with UCLA, Cedars, and other institutions. Dr. Vadgama serves on the senior leadership team of the UCLA CTSI Program. At the University president and deans' request, he has represented the University at several national forums on cancer and health disparities. He serves in an advisory capacity to the president and the Executive Team for directing research initiatives at CDU in partnership with other institutions.
    Strength in Diversity: Dr. Vadgama has over 25 years of experience working at Historically Black College and University (HBCU) and Hispanic Serving Institution (HSI). In 1992/3, he was recruited to Charles R. Drew University of Medicine and Science as Director of Laboratory Research and Development to develop Biomedical Sciences research infrastructure that supported underrepresented and underserved undergraduate students, graduate students, medical residents, clinical fellows, postdoctoral fellows, and faculty. Also, during these last 27 years and prior, he has had extensive experience working with underrepresented and under-resourced communities in South Los Angeles and neighboring communities. Dr. Vadgama states: “It continues to be an honor and privilege to be able to make differences in the day to day lives of our students, faculty, staff, and community partners.”
    Translational Cancer Research Experience: Dr. Vadgama has extensive experience in conducting oncology research that integrates clinical, basic, and community-based research. The outcome of these efforts has resulted in the development of translational cancer research at CDU. Research programs in his division focus on 1) genetics and epigenetics; 2) identification of cellular/molecular markers and novel genes for early detection, prevention, and management of breast, colorectal cancer, and prostate cancers; 3) mechanisms associated with bone metastasis from breast cancer; 4) role of mismatch repair proteins and microsatellite instability in colorectal cancer in minority populations; 5) identification and characterization of normal and cancer stem cells in breast and prostate cancers that contribute to drug resistance; 6) cancer outreach and prevention studies. 7) Dr. Vadgama and his research team are making significant


    Impact on understanding how social and epigenomic factors associated with social determinants of health in underserved and under-resourced communities impact health outcomes, focusing on cancer health disparities. Specifically, his team has identified that comorbidities such as Obesity, Diabetes, and Hypertension play a significant role in cancer health disparities.
    He has been a recipient of numerous extramural grants. Recent examples include 1) Identification of novel biomarkers associated with risk for bone metastasis from breast cancer (NIH/NCI CA15083-25S3), and 2) Role of Mismatch Repair Proteins and Microsatellite Instability in Colorectal Cancer in African American and Hispanic patients (CA 15083-25S3). Currently, he is the principal investigator of several center grants at CDU. The CDU/UCLA Cancer Center Partnership has been funded by the National Cancer Institute (U54CA143931) since 2003, with the last renewal for $12.6M (2015-2021). The partnership supports cancer disparities research at CDU and UCLA. It supports programs that develop novel cancer health disparities research. It has developed a state-of-the-art biomarker and biospecimen repository. It provides formal training in cancer research to students, fellows, faculty, community engagement activities, and clinical research studies. In addition, Dr. Vadgama serves as PI for the Accelerating Excellence in Translational Science Center (U54MD007598), recently funded for $18.76M (2019-2025). The overall purpose of the AXIS is to better position CDU for conducting clinical and translational research, especially research focused on health disparities. In response to the COVID-19 pandemic, Dr. Vadgama and the CDU team have obtained several administrative supplements from NIH (>$950K) to study health disparities associated with COVID-19 in African American and Latinx communities in South Los Angeles. They have also obtained funding for Covid-19 Vaccine Trials with Fred Hutch Cancer Center for over $1,9M.
    Other Professional Experience: Dr. Vadgama serves as a reviewer for grants submitted to the NIH, DOD, VHA, and EPSRC. He is Editor-In-Chief of IJBS, Clinics in Oncology Journal, and serves on the editorial board of 14 journals, and an ad-hoc reviewer for 30 peer-reviewed journals. Dr. Vadgama has participated at national and international cancer meetings as chair, co-chair, invited honorary, and keynote speaker. He has also served on several community-partnered panels and conferences and honored with a Distinguished Achievement Award for Research and Community Partnership award from the Watts Area Ministers (WAM). He received the “Unsung Heroes Award” by the National Community Based Organization Network for Dedicated Service and Outstanding Accomplishments in the Field of Community-Based Public Health. In addition to serving on NIH Study Section Review Committees, Dr. Vadgama serves on several advisory boards. To name a few, The Susan G. Komen® African American Health Equity Initiative (AAHEI): AAHEI Community Advisory Board; the University of California Riverside, Center for Health Disparities; and others.

    Teaching and Training Experience: Dr. Vadgama has extensive training students, residents, and fellows in basic, clinical, and translational cancer research. The NIH has funded his training programs since 2004 and serves as a mentor and reviewer for several training programs, including the CTSI and Susan G. Komen Foundation. To date, Dr. Vadgama has mentored 59 postdoctoral and clinical fellows, 34 graduate students, 16 medical students (mostly underrepresented), 149 undergraduate students across the nation, and 35 high school students. Dr. Vadgama serves as a mentor for several funded early-stage investigators at CDU and the UCLA School of Medicine. In addition, he mentors several underrepresented trainees from schools such as CDU, UCLA, UCI, UCR, CSUDH, USC, and others.

    Collapse Research 
    Collapse Research Activities and Funding
    LOC: HIV Vaccine Trials Network
    NIH UM1AI068614Jul 2, 2020 - Nov 30, 2020
    Role: Co-Investigator
    Accelerating Excellence in Translational Science (AXIS)
    NIH U54MD007598Sep 28, 2009 - Feb 29, 2024
    Role: Principal Investigator
    Accelerating Excellence in Translational Science (AXIS)
    NIH/NIMHD U54MD007598Sep 28, 2009 - Feb 29, 2024
    Role: Principal Investigator
    CDU-UCLA Cancer Center Partnership to Eliminate Cancer Health Disparities
    NIH/NCI U54CA143931Sep 28, 2009 - Aug 31, 2021
    Role: Principal Investigator
    Charles R. Drew Student Scholar Program
    NIH R25DK067015Sep 30, 2003 - Jul 31, 2009
    Role: Principal Investigator
    Drew/UCLA Cancer Partnership Program
    NIH U56CA101599Sep 5, 2003 - Jul 31, 2010
    Role: Principal Investigator
    REGULATION OF AMINO ACID TRANSPORT IN ERYTHROID CELLS
    NIH R29DK039147Aug 1, 1987 - Nov 30, 1992
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The beacon of hope program: Co-creating effective, measurable solutions for health equity. J Natl Med Assoc. 2024 Oct 16. Pemu P, Maxwell C, Singh R, Vadgama J, Arjumand S, Armstrong L. PMID: 39414489.
      View in: PubMed   Mentions:    Fields:    
    2. Engineering of layer-by-layer acetate-coated paclitaxel loaded poly(lactide-co-glycolide) acid nanoparticles for prostate cancer therapy- in vitro. J Pharm Sci. 2024 Nov; 113(11):3375-3383. Ngo AN, Chatman KK, Douglas D, Mosley-Kellum KM, Wu K, Vadgama J. PMID: 39313154.
      View in: PubMed   Mentions:
    3. [Retracted] Slug contributes to cancer progression by direct regulation of ERα signaling pathway. Int J Oncol. 2024 Nov; 65(5). Li Y, Wu Y, Abbatiello TC, Wu WL, Kim JR, Sarkissyan M, Sarkissyan S, Chung SS, Elshimali Y, Vadgama JV. PMID: 39301628; PMCID: PMC11419408.
      View in: PubMed   Mentions:    Fields:    
    4. Retraction Note: A83-01 inhibits TGF-β-induced upregulation of Wnt3 and epithelial to mesenchymal transition in HER2-overexpressing breast cancer cells. Breast Cancer Res Treat. 2024 Jul; 206(1):213. Wu Y, Tran T, Dwabe S, Sarkissyan M, Kim J, Nava M, Clayton S, Pietras R, Farias-Eisner R, Vadgama JV. PMID: 38727890.
      View in: PubMed   Mentions:    Fields:    
    5. Inflammatory Cytokines Associated with Obesity, Type-2 Diabetes, and Hypertension Exacerbate Breast Cancer Risk in Underserved African American and Latin American Women. J Clin Med. 2024 Mar 15; 13(6). Wu Y, Karapetyan E, Dutta P, Shaheen M, Vadgama JV. PMID: 38541912; PMCID: PMC10970755.
      View in: PubMed   Mentions:
    6. Correction: Wu et al. Expression of MALAT1 Promotes Trastuzumab Resistance in HER2 Overexpressing Breast Cancers. Cancers 2020, 12, 1918. Cancers (Basel). 2024 Mar 01; 16(5). Wu Y, Sarkissyan M, Ogah O, Kim J, Vadgama JV. PMID: 38473438; PMCID: PMC10931259.
      View in: PubMed   Mentions: 1  
    7. Correction: Hamilton et al. Receptors for Insulin-Like Growth Factor-2 and Androgens as Therapeutic Targets in Triple-Negative Breast Cancer. Int. J. Mol. Sci. 2017, 18, 2305. Int J Mol Sci. 2024 Feb 23; 25(5). Hamilton N, Austin D, Márquez-Garbán D, Sanchez R, Chau B, Foos K, Wu Y, Vadgama J, Pietras R. PMID: 38474325; PMCID: PMC10921924.
      View in: PubMed   Mentions:    Fields:    
    8. Enhanced Chemoprevention of Prostate Cancer by Combining Arctigenin with Green Tea and Quercetin in Prostate-Specific Phosphatase and Tensin Homolog Knockout Mice. Biomolecules. 2024 Jan 14; 14(1). Hao Q, Henning SM, Magyar CE, Said J, Zhong J, Rettig MB, Vadgama JV, Wang P. PMID: 38254705; PMCID: PMC10813217.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    9. Proteome-wide association study and functional validation identify novel protein markers for pancreatic ductal adenocarcinoma. Gigascience. 2024 01 02; 13. Zhu J, Wu K, Liu S, Masca A, Zhong H, Yang T, Ghoneim DH, Surendran P, Liu T, Yao Q, Liu T, Fahle S, Butterworth A, Alam MA, Vadgama JV, Deng Y, Deng HW, Wu C, Wu Y, Wu L. PMID: 38608280; PMCID: PMC11010651.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    10. Correction: Dutta et al. Transcriptional Regulation of CCL2 by PARP1 Is a Driver for Invasiveness in Breast Cancer. Cancers 2020, 12, 1317. Cancers (Basel). 2023 Dec 19; 16(1). Dutta P, Paico K, Gomez G, Wu Y, Vadgama JV. PMID: 38201664; PMCID: PMC10778015.
      View in: PubMed   Mentions:
    11. Optimization of tissue microarray technique for breast cancer patients: a short communication. Ann Med Surg (Lond). 2023 Oct; 85(10):5299-5303. Harfouch RM, Al-Shehabi Z, Asaad R, Aljamali M, Issa R, Elshimali Y, Vadgama J. PMID: 37811076; PMCID: PMC10553042.
      View in: PubMed   Mentions:
    12. Advancements in small molecule drug design: A structural perspective. Drug Discov Today. 2023 10; 28(10):103730. Wu K, Karapetyan E, Schloss J, Vadgama J, Wu Y. PMID: 37536390; PMCID: PMC10543554.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    13. From Interaction to Intervention: How Mesenchymal Stem Cells Affect and Target Triple-Negative Breast Cancer. Biomedicines. 2023 Apr 15; 11(4). Wu Y, Shum HCE, Wu K, Vadgama J. PMID: 37189800; PMCID: PMC10136169.
      View in: PubMed   Mentions: 2  
    14. Advancing Cancer Research: Insights and Innovations in Pathogenesis and Targeted Therapies. J Pers Med. 2023 Feb 21; 13(3). Wu Y, Vadgama JV. PMID: 36983557; PMCID: PMC10051869.
      View in: PubMed   Mentions:
    15. Potential Therapies Targeting the Metabolic Reprogramming of Diabetes-Associated Breast Cancer. J Pers Med. 2023 Jan 14; 13(1). Shum HCE, Wu K, Vadgama J, Wu Y. PMID: 36675817; PMCID: PMC9861470.
      View in: PubMed   Mentions: 1  
    16. Genetic variants in African-American and Hispanic patients with breast cancer. Oncol Lett. 2023 Feb; 25(2):51. Dutta P, Keung MY, Wu Y, Vadgama JV. PMID: 36644153; PMCID: PMC9811638.
      View in: PubMed   Mentions: 1  
    17. CircRAD54L2 promotes triple-negative breast cancer progression by regulating the miR-888 family/PDK1 axis. Life Sci. 2023 Jan 01; 312:121128. He Q, Hao Q, Wu Y, Vadgama JV, Jiang Y. PMID: 36334805; PMCID: PMC10078949.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    18. Squalamines in Blockade of Tumor-Associated Angiogenesis and Cancer Progression. Cancers (Basel). 2022 Oct 21; 14(20). Sterling C, Márquez-Garbán D, Vadgama JV, Pietras RJ. PMID: 36291938; PMCID: PMC9601113.
      View in: PubMed   Mentions: 2  
    19. Phytochemicals in Inhibition of Prostate Cancer: Evidence from Molecular Mechanisms Studies. Biomolecules. 2022 09 16; 12(9). Hao Q, Wu Y, Vadgama JV, Wang P. PMID: 36139145; PMCID: PMC9496067.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    20. Diaporine Potentiates the Anticancer Effects of Oxaliplatin and Doxorubicin on Liver Cancer Cells. J Pers Med. 2022 Aug 16; 12(8). Tian S, Su R, Wu K, Zhou X, Vadgama JV, Wu Y. PMID: 36013267; PMCID: PMC9410505.
      View in: PubMed   Mentions: 1  
    21. ZBED2 expression enhances interferon signaling and predicts better survival of estrogen receptor-negative breast cancer patients. Cancer Commun (Lond). 2022 07; 42(7):663-667. Liu D, Hao Q, Li J, Li Q, Wang K, Geng Q, Wu Y, Vadgama JV, Wu Y. PMID: 35486908; PMCID: PMC9257990.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    22. Roles of Protein Disulfide Isomerase in Breast Cancer. Cancers (Basel). 2022 Jan 31; 14(3). Yang S, Jackson C, Karapetyan E, Dutta P, Kermah D, Wu Y, Wu Y, Schloss J, Vadgama JV. PMID: 35159012; PMCID: PMC8833603.
      View in: PubMed   Mentions: 7  
    23. Tumor-Derived Exosomes in Tumor-Induced Immune Suppression. Int J Mol Sci. 2022 Jan 27; 23(3). Hao Q, Wu Y, Wu Y, Wang P, Vadgama JV. PMID: 35163380; PMCID: PMC8836190.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    24. A Novel Metabolic Reprogramming Strategy for the Treatment of Diabetes-Associated Breast Cancer. Adv Sci (Weinh). 2022 02; 9(6):e2102303. Hao Q, Huang Z, Li Q, Liu D, Wang P, Wang K, Li J, Cao W, Deng W, Wu K, Su R, Liu Z, Vadgama J, Wu Y. PMID: 35023320; PMCID: PMC8867195.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    25. Elevated Baseline Serum PD-L1 Level May Predict Poor Outcomes from Breast Cancer in African-American and Hispanic Women. J Clin Med. 2022 Jan 06; 11(2). Wu Y, Dutta P, Clayton S, McCloud A, Vadgama JV. PMID: 35053979; PMCID: PMC8779890.
      View in: PubMed   Mentions: 1  
    26. Wild-Type TP53 Predicts Poor Prognosis in Patients with Gastric Cancer. J Cancer Sci Clin Ther. 2021 Mar 18; 5(1):134-153. Deng W, Hao Q, Vadgama J, Wu Y. PMID: 34950877; PMCID: PMC8694034.
      View in: PubMed   Mentions: 5  
    27. Basal-like breast cancer with low TGFβ and high TNFα pathway activity is rich in activated memory CD4 T cells and has a good prognosis. Int J Biol Sci. 2021; 17(3):670-682. Liu D, Vadgama J, Wu Y. PMID: 33767579; PMCID: PMC7975701.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    28. Endometriosis: A Malignant Fingerprint. J Cancer Res Ther Oncol. 2020 Apr; 8(2). DeAngelo C, Tarasiewicz MB, Strother A, Taggart H, Gray C, Shanahan M, Glowacki C, Khandalavala J, Talaska E, Kinnan A, Coté JJ, Edwards AP, Harper-Harrison G, Casey MJ, Hirai TL, Schultz S, Stines L, Vora R, Boudreau D, Burgart J, Shama M, Watson T, Strasheim L, Thompson R, Lawlor R, Joyce K, Magnuson CM, Driano J, Elger B, Lentino A, Driscoll M, Tidwell E, Sharma A, Walker SR, Jones G, Sharma P, Stessman H, Wu Y, Vadgama J, Chase D, Conrad L, Reddy ST, Farias-Eisner R. PMID: 33644256; PMCID: PMC7909468.
      View in: PubMed   Mentions: 3  
    29. Comp34 displays potent preclinical antitumor efficacy in triple-negative breast cancer via inhibition of NUDT3-AS4, a novel oncogenic long noncoding RNA. Cell Death Dis. 2020 12 11; 11(12):1052. Hao Q, Wang P, Dutta P, Chung S, Li Q, Wang K, Li J, Cao W, Deng W, Geng Q, Schrode K, Shaheen M, Wu K, Zhu D, Chen QH, Chen G, Elshimali Y, Vadgama J, Wu Y. PMID: 33311440; PMCID: PMC7733521.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    30. Nicotine Synergizes with High-Fat Diet to Induce an Anti-Inflammatory Microenvironment to Promote Breast Tumor Growth. Mediators Inflamm. 2020; 2020:5239419. Jimenez T, Friedman T, Vadgama J, Singh V, Tucker A, Collazo J, Sinha S, Hikim AS, Singh R, Pervin S. PMID: 33414685; PMCID: PMC7752272.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    31. Expression of MALAT1 Promotes Trastuzumab Resistance in HER2 Overexpressing Breast Cancers. Cancers (Basel). 2020 Jul 16; 12(7). Wu Y, Sarkissyan M, Ogah O, Kim J, Vadgama JV. PMID: 32708561; PMCID: PMC7409266.
      View in: PubMed   Mentions: 12  
    32. CCL2/CCR2 signaling in cancer pathogenesis. Cell Commun Signal. 2020 05 29; 18(1):82. Hao Q, Vadgama JV, Wang P. PMID: 32471499; PMCID: PMC7257158.
      View in: PubMed   Mentions: 117     Fields:    Translation:HumansAnimals
    33. EMP2 Is a Novel Regulator of Stemness in Breast Cancer Cells. Mol Cancer Ther. 2020 08; 19(8):1682-1695. Dillard C, Kiyohara M, Mah V, McDermott SP, Bazzoun D, Tsui J, Chan AM, Haddad G, Pellegrini M, Chang YL, Elshimali Y, Wu Y, Vadgama JV, Kim SR, Goodglick L, Law SM, Patel DD, Dhawan P, O'Brien NA, Gordon LK, Braun J, Lazar G, Wicha MS, Wadehra M. PMID: 32451329; PMCID: PMC7415657.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    34. Transcriptional Regulation of CCL2 by PARP1 Is a Driver for Invasiveness in Breast Cancer. Cancers (Basel). 2020 May 21; 12(5). Dutta P, Paico K, Gomez G, Wu Y, Vadgama JV. PMID: 32455851; PMCID: PMC7281677.
      View in: PubMed   Mentions: 9  
    35. Response of Breast Cancer Cells to PARP Inhibitors Is Independent of BRCA Status. J Clin Med. 2020 Mar 30; 9(4). Keung MY, Wu Y, Badar F, Vadgama JV. PMID: 32235451; PMCID: PMC7231148.
      View in: PubMed   Mentions: 48  
    36. The role of PPM1D in cancer and advances in studies of its inhibitors. Biomed Pharmacother. 2020 May; 125:109956. Deng W, Li J, Dorrah K, Jimenez-Tapia D, Arriaga B, Hao Q, Cao W, Gao Z, Vadgama J, Wu Y. PMID: 32006900; PMCID: PMC7080581.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    37. Arctigenin inhibits prostate tumor growth in high-fat diet fed mice through dual actions on adipose tissue and tumor. Sci Rep. 2020 Jan 29; 10(1):1403. Hao Q, Diaz T, Verduzco ADR, Magyar CE, Zhong J, Elshimali Y, Rettig MB, Henning SM, Vadgama JV, Wang P. PMID: 31996731; PMCID: PMC6989655.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    38. Bovine HDL and Dual Domain HDL-Mimetic Peptides Inhibit Tumor Development in Mice. J Cancer Res Ther Oncol. 2020; 8(1). Su F, Gm A, Palgunachari MN, White CR, Stessman H, Wu Y, Vadgama J, Pietras R, Nguyen D, Reddy ST, Farias-Eisner R. PMID: 32462055; PMCID: PMC7252215.
      View in: PubMed   Mentions: 4  
    39. PP2Cδ inhibits p300-mediated p53 acetylation via ATM/BRCA1 pathway to impede DNA damage response in breast cancer. Sci Adv. 2019 10; 5(10):eaaw8417. Li Q, Hao Q, Cao W, Li J, Wu K, Elshimali Y, Zhu D, Chen QH, Chen G, Pollack JR, Vadgama J, Wu Y. PMID: 31663018; PMCID: PMC6795508.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    40. A novel curcumin analog inhibits canonical and non-canonical functions of telomerase through STAT3 and NF-κB inactivation in colorectal cancer cells. Oncotarget. 2019 Jul 16; 10(44):4516-4531. Chung SS, Dutta P, Chard N, Wu Y, Chen QH, Chen G, Vadgama J. PMID: 31360301; PMCID: PMC6642039.
      View in: PubMed   Mentions: 17     Fields:    
    41. PARP Inhibitors as a Therapeutic Agent for Homologous Recombination Deficiency in Breast Cancers. J Clin Med. 2019 Mar 30; 8(4). Keung MYT, Wu Y, Vadgama JV. PMID: 30934991; PMCID: PMC6517993.
      View in: PubMed   Mentions: 71  
    42. Utilization of NGS technologies to investigate transcriptomic and epigenomic mechanisms in trastuzumab resistance. Sci Rep. 2019 03 26; 9(1):5141. Nava M, Dutta P, Farias-Eisner R, Vadgama JV, Wu Y. PMID: 30914750; PMCID: PMC6435657.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    43. A review of the effects of healthcare disparities on the experience and survival of ovarian cancer patients of different racial and ethnic backgrounds. J Cancer Metastasis Treat. 2019; 5. Kaufman M, Cruz A, Thompson J, Reddy S, Bansal N, Cohen JG, Wu Y, Vadgama J, Farias-Eisner R. PMID: 31236478; PMCID: PMC6590085.
      View in: PubMed   Mentions: 6  
    44. AMP-activated protein kinase: a potential therapeutic target for triple-negative breast cancer. Breast Cancer Res. 2019 02 21; 21(1):29. Cao W, Li J, Hao Q, Vadgama JV, Wu Y. PMID: 30791936; PMCID: PMC6385460.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    45. The Research Centers in Minority Institutions (RCMI) Translational Research Network: Building and Sustaining Capacity for Multi-Site Basic Biomedical, Clinical and Behavioral Research. Ethn Dis. 2019; 29(Suppl 1):135-144. Ofili EO, Tchounwou PB, Fernandez-Repollet E, Yanagihara R, Akintobi TH, Lee JE, Malouhi M, Garner ST, Hayes TT, Baker AR, Dent AL, Abdelrahim M, Rollins L, Chang SP, Sy A, Hernandez BY, Bullard PL, Noel RJ, Shiramizu B, Hedges JR, Berry MJ, Bond VC, Lima MF, Mokuau N, Kirken RA, Cruz-Correa M, Sarpong DF, Vadgama J, Yates C, Kahn SA, Soliman KF, Perry G, Pezzano M, Luciano CA, Barnett ME, Oyekan A, Kumar D, Norris KC, RCMI Investigators and RTRN Team Members. PMID: 30906162; PMCID: PMC6428183.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    46. Transcriptomic and ChIP-sequence interrogation of EGFR signaling in HER2+ breast cancer cells reveals a dynamic chromatin landscape and S100 genes as targets. BMC Med Genomics. 2019 02 08; 12(1):32. Nava M, Dutta P, Zemke NR, Farias-Eisner R, Vadgama JV, Wu Y. PMID: 30736768; PMCID: PMC6368760.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    47. Celecoxib in breast cancer prevention and therapy. Cancer Manag Res. 2018; 10:4653-4667. Li J, Hao Q, Cao W, Vadgama JV, Wu Y. PMID: 30464589; PMCID: PMC6208493.
      View in: PubMed   Mentions: 30  
    48. Estrogen receptor-beta is a potential target for triple negative breast cancer treatment. Oncotarget. 2018 Sep 21; 9(74):33912-33930. Austin D, Hamilton N, Elshimali Y, Pietras R, Wu Y, Vadgama J. PMID: 30338035; PMCID: PMC6188058.
      View in: PubMed   Mentions: 29     Fields:    
    49. Combination of resveratrol and 5-flurouracil enhanced anti-telomerase activity and apoptosis by inhibiting STAT3 and Akt signaling pathways in human colorectal cancer cells. Oncotarget. 2018 Aug 31; 9(68):32943-32957. Chung SS, Dutta P, Austin D, Wang P, Awad A, Vadgama JV. PMID: 30250641; PMCID: PMC6152483.
      View in: PubMed   Mentions: 30     Fields:    
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    57. GROα overexpression drives cell migration and invasion in triple negative breast cancer cells. Oncol Rep. 2017 Jul; 38(1):21-30. Bhat K, Sarkissyan M, Wu Y, Vadgama JV. PMID: 28560447; PMCID: PMC5492847.
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    61. Aberrant Phosphorylation of SMAD4 Thr277-Mediated USP9x-SMAD4 Interaction by Free Fatty Acids Promotes Breast Cancer Metastasis. Cancer Res. 2017 03 15; 77(6):1383-1394. Wu Y, Yu X, Yi X, Wu K, Dwabe S, Atefi M, Elshimali Y, Kemp KT, Bhat K, Haro J, Sarkissyan M, Vadgama JV. PMID: 28115363; PMCID: PMC5354968.
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    63. Long-term exposure of MCF-7 breast cancer cells to ethanol stimulates oncogenic features. Int J Oncol. 2017 Jan; 50(1):49-65. Gelfand R, Vernet D, Bruhn KW, Sarkissyan S, Heber D, Vadgama JV, Gonzalez-Cadavid NF. PMID: 27959387; PMCID: PMC5182011.
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    68. Diabetes-associated dysregulated cytokines and cancer. Integr Cancer Sci Ther. 2016 Feb; 3(1):370-378. Wu Y, Liu Y, Dong Y, Vadgama J. PMID: 29930868; PMCID: PMC6007890.
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    71. Understanding Perceived Benefit of Early Cancer Detection: Community-Partnered Research with African American Women in South Los Angeles. J Womens Health (Larchmt). 2015 Sep; 24(9):755-61. Bazargan M, Lucas-Wright A, Jones L, Vargas R, Vadgama JV, Evers-Manly S, Maxwell AE. PMID: 26131760; PMCID: PMC4589099.
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    72. Combined inhibition of glycolysis and AMPK induces synergistic breast cancer cell killing. Breast Cancer Res Treat. 2015 Jun; 151(3):529-39. Wu Y, Sarkissyan M, Mcghee E, Lee S, Vadgama JV. PMID: 25975952; PMCID: PMC4668274.
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    73. Biologic roles of estrogen receptor-β and insulin-like growth factor-2 in triple-negative breast cancer. Biomed Res Int. 2015; 2015:925703. Hamilton N, Márquez-Garbán D, Mah V, Fernando G, Elshimali Y, Garbán H, Elashoff D, Vadgama J, Goodglick L, Pietras R. PMID: 25874233; PMCID: PMC4385615.
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    77. Curcumin and epigallocatechin gallate inhibit the cancer stem cell phenotype via down-regulation of STAT3-NFκB signaling. Anticancer Res. 2015 Jan; 35(1):39-46. Chung SS, Vadgama JV. PMID: 25550533; PMCID: PMC4290892.
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    86. Constitutive activation of STAT3 signaling regulates hTERT and promotes stem cell-like traits in human breast cancer cells. PLoS One. 2013; 8(12):e83971. Chung SS, Aroh C, Vadgama JV. PMID: 24386318; PMCID: PMC3875492.
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    88. Triple negative breast tumors in African-American and Hispanic/Latina women are high in CD44+, low in CD24+, and have loss of PTEN. PLoS One. 2013; 8(10):e78259. Wu Y, Sarkissyan M, Elshimali Y, Vadgama JV. PMID: 24167614; PMCID: PMC3805609.
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    91. Genomic and functional characterizations of phosphodiesterase subtype 4D in human cancers. Proc Natl Acad Sci U S A. 2013 Apr 09; 110(15):6109-14. Lin DC, Xu L, Ding LW, Sharma A, Liu LZ, Yang H, Tan P, Vadgama J, Karlan BY, Lester J, Urban N, Schummer M, Doan N, Said JW, Sun H, Walsh M, Thomas CJ, Patel P, Yin D, Chan D, Koeffler HP. PMID: 23536305; PMCID: PMC3625360.
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    92. Vitamin D receptor gene polymorphisms and prognosis of breast cancer among African-American and Hispanic women. PLoS One. 2013; 8(3):e57967. Mishra DK, Wu Y, Sarkissyan M, Sarkissyan S, Chen Z, Shang X, Ong M, Heber D, Koeffler HP, Vadgama JV. PMID: 23554871; PMCID: PMC3595235.
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    94. Expression of Wnt3 activates Wnt/β-catenin pathway and promotes EMT-like phenotype in trastuzumab-resistant HER2-overexpressing breast cancer cells. Mol Cancer Res. 2012 Dec; 10(12):1597-606. Wu Y, Ginther C, Kim J, Mosher N, Chung S, Slamon D, Vadgama JV. PMID: 23071104; PMCID: PMC3732195.
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    97. Expression of connective tissue growth factor (CTGF/CCN2) in breast cancer cells is associated with increased migration and angiogenesis. Int J Oncol. 2011 Jun; 38(6):1741-7. Chien W, O'Kelly J, Lu D, Leiter A, Sohn J, Yin D, Karlan B, Vadgama J, Lyons KM, Koeffler HP. PMID: 21455569; PMCID: PMC3711677.
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    99. Connective tissue growth factor associated with oncogenic activities and drug resistance in glioblastoma multiforme. Int J Cancer. 2010 Nov 15; 127(10):2257-67. Yin D, Chen W, O'Kelly J, Lu D, Ham M, Doan NB, Xie D, Wang C, Vadgama J, Said JW, Black KL, Koeffler HP. PMID: 20162579; PMCID: PMC2946420.
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    101. Caspase 8 and maspin are downregulated in breast cancer cells due to CpG site promoter methylation. BMC Cancer. 2010 Feb 04; 10:32. Wu Y, Alvarez M, Slamon DJ, Koeffler P, Vadgama JV. PMID: 20132554; PMCID: PMC2824712.
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    102. Global methylation pattern of genes in androgen-sensitive and androgen-independent prostate cancer cells. Mol Cancer Ther. 2010 Jan; 9(1):33-45. Mishra DK, Chen Z, Wu Y, Sarkissyan M, Koeffler HP, Vadgama JV. PMID: 20053773; PMCID: PMC2806502.
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    103. Role of caspases in 5-FU and selenium-induced growth inhibition of colorectal cancer cells. Anticancer Res. 2008 Nov-Dec; 28(6A):3579-92. Thant AA, Wu Y, Lee J, Mishra DK, Garcia H, Koeffler HP, Vadgama JV. PMID: 19189638; PMCID: PMC3771536.
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    104. Clinical significance of Akt and HER2/neu overexpression in African-American and Latina women with breast cancer. Breast Cancer Res. 2008; 10(1):R3. Wu Y, Mohamed H, Chillar R, Ali I, Clayton S, Slamon D, Vadgama JV. PMID: 18184439; PMCID: PMC2374954.
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    105. Clinical significance of incidental colorectal wall thickening on computed tomography scan in African-American and Hispanic patients. Dig Dis Sci. 2007 Nov; 52(11):3159-64. Padda M, Vadgama J, Sandhu P, Dev A, Giannikopoulos I. PMID: 17404851.
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    106. Taxol induced apoptosis regulates amino acid transport in breast cancer cells. Apoptosis. 2007 Mar; 12(3):593-612. Wu Y, Shen D, Chen Z, Clayton S, Vadgama JV. PMID: 17195090.
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    107. Insulin-like growth factor I differentially regulates the expression of HIRF1/hCAF1 and BTG1 genes in human MCF-7 breast cancer cells. Int J Mol Med. 2006 Jul; 18(1):129-39. Vadgama JV, Scuric Z, Chakrabarti R, Marzo E, Shen D, Wu Y. PMID: 16786164.
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    108. Novel Gemini-vitamin D3 analog inhibits tumor cell growth and modulates the Akt/mTOR signaling pathway. J Steroid Biochem Mol Biol. 2006 Aug; 100(4-5):107-16. O'Kelly J, Uskokovic M, Lemp N, Vadgama J, Koeffler HP. PMID: 16777406.
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    123. Elevated basal cytosolic calcium attenuates IGF-I stimulation of protein synthesis in cardiomyocytes of rats with chronic renal failure. Journal of the American Society of Nephrology. 1999; (10):84-92. Qing DP, Ding H, Vadgama JV, Wu Y, Kopple JD.
    124. Accumulation of albumin in renal cytosol of hamsters treated with estradiol and in estrogen-induced hamster kidney tumors. Int J Oncol. 1998 Nov; 13(5):1087-91. Bhat HK, Vadgama JV, Liehr JG. PMID: 9772304.
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    125. Amino Acid Transport in Keloid Fibroblast. Investigative Dermatology. 1995. Vadgama JV, Chang KC, Franklin KM, Kelly AP.
    126. Role of Glutamine in Regulating Glutamine Transport & Globin Gene Expression in Human Erythroleukemia Cells K562. 3rd International Congress on Amino Acids, Peptides, & Analogues. Amino Acids. 1993; 203(5). Vadgama JV, Chang K, Chang B, Lin HJ.
    127. Lysosomal transport of small molecules. Biochem Med Metab Biol. 1992 Dec; 48(3):179-93. Chou HF, Vadgama J, Jonas AJ. PMID: 1476786.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    128. Absorption of amino acids from the human mouth. Amino Acids. 1992 Oct; 3(3):271-86. Vadgama JV, Evered DF. PMID: 24193127.
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    129. Lysosomal sulfate transport. Pathophysiology of Lysosomal Transport. 1992; 133-154. Vadgama JV, Jonas AJ.
    130. Characterization of threonine transport into a kidney epithelial cell line (BSC-1). Evidence for the presence of Na(+)-independent system asc [corrected]. J Biol Chem. 1991 Aug 15; 266(23):15042-7. Kuhlmann MK, Vadgama JV. PMID: 1907970.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    131. Characteristics of taurine transport in rat liver lysosomes. J Cell Physiol. 1991 Jun; 147(3):447-54. Vadgama JV, Chang K, Kopple JD, Idriss JM, Jonas AJ. PMID: 2066365.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    132. Differential expression of amino acid transport systems A and ASC during erythroleukemia cell differentiation. Am J Physiol. 1991 Mar; 260(3 Pt 1):C392-9. Vadgama JV, Chan MN, Wu JM. PMID: 1900666.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    133. Nutritional and Metabolic Implications of Acute Renal Failure. Renal Nutrition. 1991; 58-64. Brunori G, Leiserowitz M, Shamir E, Kuhlmann M, Vadgama JV, Kopple JD.
    134. Design of simple devices to measure solute fluxes and binding in monolayer cell cultures. Methods Enzymol. 1989; 171:133-44. Vadgama JV. PMID: 2593839.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    135. Characterization of amino acid transport during erythroid cell differentiation. J Biol Chem. 1987 Sep 25; 262(27):13273-84. Vadgama JV, Castro M, Christensen HN. PMID: 3654612.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    136. A new Na+-independent transport system for dipolar amino acids apparently corresponding to systems persisting after erythrocyte maturation in some mammalian genotypes. Ann N Y Acad Sci. 1985; 456:454-6. Vadgama JV, Christensen HN. PMID: 3937471.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    137. Naming plan for membrane transport systems for amino acids. Neurochem Res. 1984 Dec; 9(12):1757-8. Christensen HN. PMID: 6531071.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    138. Amino acid transport systems. Nature. 1984 Sep 27-Oct 3; 311(5984):308. Bannai S, Christensen HN, Vadgama JV, Ellory JC, Englesberg E, Guidotti GG, Gazzola GC, Kilberg MS, Lajtha A, Sacktor B, et al. PMID: 6482960.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    139. Wide distribution of pH-dependent service of transport system ASC for both anionic and zwitterionic amino acids. J Biol Chem. 1984 Mar 25; 259(6):3648-52. Vadgama JV, Christensen HN. PMID: 6423635.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    140. Synthesis and transport applications of 3-aminobicyclo[3.2.1] octane-3-carboxylic acids. J Med Chem. 1983 Oct; 26(10):1374-8. Christensen HN, Handlogten ME, Vadgama JV, de la Cuesta E, Ballesteros P, Trigo GG, Avendaño C. PMID: 6413692.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    141. Comparison of system N in fetal hepatocytes and in related cell lines. J Biol Chem. 1983 May 25; 258(10):6422-9. Vadgama JV, Christensen HN. PMID: 6304040.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    142. Absorption of homocitrulline from the gastrointestinal tract. Br J Nutr. 1983 Jan; 49(1):35-42. Evered DF, Vadgama JV. PMID: 6821687.
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    143. Changes in Amino Acid Transport Systems on Maturation and Transformation of Rat Hepatocytes. Isolation, Characterization, and Use of Hepatocytes. 1983; 217-226. Christensen HN, Makowske M, Vadgama JV.
    144. Absorption of amino acids from the human buccal cavity. Biochem Soc Trans. 1981 Feb; 9(1):132-3. Evered DF, Vadgama JV. PMID: 7215641.
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