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Madhuri Wadehra

Title(s)Associate Adjunct Professor, Pathology and Laboratory Medicine
SchoolMedicine
Address760 Westwood Plaza A3-251
Los Angeles CA 90024
Phone56653
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    Collapse Research 
    Collapse Research Activities and Funding
    Targeting EMP2 for the treatment of triple negative breast cancer with novel anti-EMP2 Granzyme B immunoconjugates
    NIH/NCI R21CA234642Jul 1, 2019 - Jun 30, 2021
    Role: Principal Investigator
    Using EMP2 for Image Guided Drug Delivery for Breast Cancer
    NIH/NCI R01CA163971Jul 9, 2012 - Apr 30, 2017
    Role: Principal Investigator
    Targeting EMP2 in Endometrial Cancer
    NIH/NCI R21CA131756May 24, 2009 - Apr 30, 2012
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. EMP2 Is a Novel Regulator of Stemness in Breast Cancer Cells. Mol Cancer Ther. 2020 Aug; 19(8):1682-1695. Dillard C, Kiyohara M, Mah V, McDermott SP, Bazzoun D, Tsui J, Chan AM, Haddad G, Pellegrini M, Chang YL, Elshimali Y, Wu Y, Vadgama JV, Kim SR, Goodglick L, Law SM, Patel DD, Dhawan P, O'Brien NA, Gordon LK, Braun J, Lazar G, Wicha MS, Wadehra M. PMID: 32451329.
      View in: PubMed   Mentions:    Fields:    
    2. Epithelial Membrane Protein 2 (EMP2) Promotes VEGF-Induced Pathological Neovascularization in Murine Oxygen-Induced Retinopathy. Invest Ophthalmol Vis Sci. 2020 02 07; 61(2):3. Sun M, Wadehra M, Casero D, Lin MC, Aguirre B, Parikh S, Matynia A, Gordon L, Chu A. PMID: 32031575.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    3. Identification of epithelial membrane protein 2 (EMP2) as a molecular marker and correlate for angiogenesis in meningioma. J Neurooncol. 2020 Mar; 147(1):15-24. Patel KS, Kejriwal S, Sun MM, Thammachantha S, Duong C, Chan A, Cherian N, Romiyo P, Gordon LK, Yong W, Wadehra M, Yang I. PMID: 31981014.
      View in: PubMed   Mentions:    Fields:    
    4. Gene-environment regulatory circuits of right ventricular pathology in tetralogy of fallot. J Mol Med (Berl). 2019 12; 97(12):1711-1722. Zhao Y, Kang X, Gao F, Guzman A, Lau RP, Biniwale R, Wadehra M, Reemtsen B, Garg M, Halnon N, Quintero-Rivera F, Van Arsdell G, Coppola G, Nelson SF, Touma M. PMID: 31834445.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. Aldehyde dehydrogenase isoforms and inflammatory cell populations are differentially expressed in term human placentas affected by intrauterine growth restriction. Placenta. 2019 06; 81:9-17. Chu A, Najafzadeh P, Sullivan P, Cone B, Elshimali R, Shakeri H, Janzen C, Mah V, Wadehra M. PMID: 31138432.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    6. The Placental Transcriptome in Late Gestational Hypoxia Resulting in Murine Intrauterine Growth Restriction Parallels Increased Risk of Adult Cardiometabolic Disease. Sci Rep. 2019 02 04; 9(1):1243. Chu A, Casero D, Thamotharan S, Wadehra M, Cosi A, Devaskar SU. PMID: 30718791.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    7. Epithelial Membrane Protein-2 (EMP2) Antibody Blockade Reduces Corneal Neovascularization in an In Vivo Model. Invest Ophthalmol Vis Sci. 2019 01 02; 60(1):245-254. Sun MM, Chan AM, Law SM, Duarte S, Diaz-Aguilar D, Wadehra M, Gordon LK. PMID: 30646013.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    8. Tissue microarray analysis for epithelial membrane protein-2 as a novel biomarker for gliomas. Brain Tumor Pathol. 2018 Jan; 35(1):1-9. Chung LK, Pelargos PE, Chan AM, Demos JV, Lagman C, Sheppard JP, Nguyen T, Chang YL, Hojat SA, Prins RM, Liau LM, Nghiemphu L, Lai A, Cloughesy TF, Yong WH, Gordon LK, Wadehra M, Yang I. PMID: 28887715.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    9. Epithelial membrane protein 2: Molecular interactions and clinical implications. J Clin Neurosci. 2017 Oct; 44:84-88. Chung LK, Bhatt NS, Lagman C, Pelargos PE, Qin Y, Gordon LK, Wadehra M, Yang I. PMID: 28720310.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    10. EMP2 is a novel therapeutic target for endometrial cancer stem cells. Oncogene. 2017 10 19; 36(42):5793-5807. Kiyohara MH, Dillard C, Tsui J, Kim SR, Lu J, Sachdev D, Goodglick L, Tong M, Torous VF, Aryasomayajula C, Wang W, Najafzadeh P, Gordon LK, Braun J, McDermott S, Wicha MS, Wadehra M. PMID: 28604744.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    11. Epithelial membrane protein-2 (EMP2) promotes angiogenesis in glioblastoma multiforme. J Neurooncol. 2017 Aug; 134(1):29-40. Qin Y, Takahashi M, Sheets K, Soto H, Tsui J, Pelargos P, Antonios JP, Kasahara N, Yang I, Prins RM, Braun J, Gordon LK, Wadehra M. PMID: 28597184.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    12. Epithelial membrane protein 2 (EMP2) deficiency alters placental angiogenesis, mimicking features of human placental insufficiency. J Pathol. 2017 06; 242(2):246-259. Williams CJ, Chu A, Jefferson WN, Casero D, Sudhakar D, Khurana N, Hogue CP, Aryasomayajula C, Patel P, Sullivan P, Padilla-Banks E, Mohandessi S, Janzen C, Wadehra M. PMID: 28295343.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    13. Gestational food restriction decreases placental interleukin-10 expression and markers of autophagy and endoplasmic reticulum stress in murine intrauterine growth restriction. Nutr Res. 2016 10; 36(10):1055-1067. Chu A, Thamotharan S, Ganguly A, Wadehra M, Pellegrini M, Devaskar SU. PMID: 27865347.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    14. Imaging of Angiotropism/Vascular Co-Option in a Murine Model of Brain Melanoma: Implications for Melanoma Progression along Extravascular Pathways. Sci Rep. 2016 Apr 06; 6:23834. Bentolila LA, Prakash R, Mihic-Probst D, Wadehra M, Kleinman HK, Carmichael TS, Péault B, Barnhill RL, Lugassy C. PMID: 27048955.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    15. Regulation of FAK Activity by Tetraspan Proteins: Potential Clinical Implications in Cancer. Crit Rev Oncog. 2015; 20(5-6):391-405. Qin Y, Mohandessi S, Gordon L, Wadehra M. PMID: 27279237.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    16. Review of the GAS3 Family of Proteins and their Relevance to Cancer. Crit Rev Oncog. 2015; 20(5-6):435-47. Ashki N, Gordon L, Wadehra M. PMID: 27279240.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    17. Angiotropism, pericytic mimicry and extravascular migratory metastasis in melanoma: an alternative to intravascular cancer dissemination. Cancer Microenviron. 2014 Dec; 7(3):139-52. Lugassy C, Zadran S, Bentolila LA, Wadehra M, Prakash R, Carmichael ST, Kleinman HK, Péault B, Larue L, Barnhill RL. PMID: 25304454.
      View in: PubMed   Mentions:
    18. Peroxynitrite upregulates angiogenic factors VEGF-A, BFGF, and HIF-1a in human corneal limbal epithelial cells. Invest Ophthalmol Vis Sci. 2014 Mar 19; 55(3):1637-46. Ashki N, Chan AM, Qin Y, Wang W, Kiyohara M, Lin L, Braun J, Wadehra M, Gordon LK. PMID: 24398102.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    19. Epithelial membrane protein-2 (EMP2) activates Src protein and is a novel therapeutic target for glioblastoma. J Biol Chem. 2014 May 16; 289(20):13974-85. Qin Y, Fu M, Takahashi M, Iwanami A, Kuga D, Rao RG, Sudhakar D, Huang T, Kiyohara M, Torres K, Dillard C, Inagaki A, Kasahara N, Goodglick L, Braun J, Mischel PS, Gordon LK, Wadehra M. PMID: 24644285.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    20. Rationale and preclinical efficacy of a novel anti-EMP2 antibody for the treatment of invasive breast cancer. Mol Cancer Ther. 2014 Apr; 13(4):902-15. Fu M, Maresh EL, Helguera GF, Kiyohara M, Qin Y, Ashki N, Daniels-Wells TR, Aziz N, Gordon LK, Braun J, Elshimali Y, Soslow RA, Penichet ML, Goodglick L, Wadehra M. PMID: 24448822.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    21. Could pericytic mimicry represent another type of melanoma cell plasticity with embryonic properties? Pigment Cell Melanoma Res. 2013 Sep; 26(5):746-54. Lugassy C, Péault B, Wadehra M, Kleinman HK, Barnhill RL. PMID: 23789776.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    22. Epithelial membrane protein 2 controls VEGF expression in ARPE-19 cells. Invest Ophthalmol Vis Sci. 2013 Mar 28; 54(3):2367-72. Morales SA, Telander DG, Leon D, Forward K, Braun J, Wadehra M, Gordon LK. PMID: 23439602.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    23. Positron emission tomography imaging of endometrial cancer using engineered anti-EMP2 antibody fragments. Mol Imaging Biol. 2013 Feb; 15(1):68-78. Fu M, Brewer S, Olafsen T, Wu AM, Gordon LK, Said J, Braun J, Wadehra M. PMID: 22585360.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    24. EMP2 regulates angiogenesis in endometrial cancer cells through induction of VEGF. Oncogene. 2013 Nov 14; 32(46):5369-76. Gordon LK, Kiyohara M, Fu M, Braun J, Dhawan P, Chan A, Goodglick L, Wadehra M. PMID: 23334331.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    25. Pilot study on "pericytic mimicry" and potential embryonic/stem cell properties of angiotropic melanoma cells interacting with the abluminal vascular surface. Cancer Microenviron. 2013 Apr; 6(1):19-29. Lugassy C, Wadehra M, Li X, Corselli M, Akhavan D, Binder SW, Péault B, Cochran AJ, Mischel PS, Kleinman HK, Barnhill RL. PMID: 23275074.
      View in: PubMed   Mentions:
    26. Anti-EMP2 diabody blocks epithelial membrane protein 2 (EMP2) and FAK mediated collagen gel contraction in ARPE-19 cells. Exp Eye Res. 2012 Sep; 102:10-6. Morales SA, Telander DG, Mareninov S, Nagy A, Wadehra M, Braun J, Gordon LK. PMID: 22728127.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    27. Expression of thyroid transcription factor-1 in normal endometrium is associated with risk of endometrial cancer development. Mod Pathol. 2012 Aug; 25(8):1140-8. Sullivan PS, Maresh EL, Seligson DB, Habeeb O, Wadehra M, Goodglick L, Dorigo O. PMID: 22460811.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    28. Rewiring integrin-mediated signaling and cellular response with the peripheral myelin protein 22 and epithelial membrane protein 2 components of the tetraspan web. Invest Ophthalmol Vis Sci. 2011 Jul 23; 52(8):5465-72. Morales SA, Telander D, Notterpek L, Wadehra M, Braun J, Gordon LK. PMID: 21421883.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    29. Epithelial membrane protein-2 promotes endometrial tumor formation through activation of FAK and Src. PLoS One. 2011; 6(5):e19945. Fu M, Rao R, Sudhakar D, Hogue CP, Rutta Z, Morales S, Gordon LK, Braun J, Goodglick L, Wadehra M. PMID: 21637765.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    30. Peripheral myelin protein-22 (PMP22) modulates alpha 6 integrin expression in the human endometrium. Reprod Biol Endocrinol. 2011 Apr 25; 9:56. Rao RG, Sudhakar D, Hogue CP, Amici S, Gordon LK, Braun J, Notterpek L, Goodglick L, Wadehra M. PMID: 21518455.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    31. Epithelial membrane protein-2 expression is an early predictor of endometrial cancer development. Cancer. 2010 Oct 15; 116(20):4718-26. Habeeb O, Goodglick L, Soslow RA, Rao RG, Gordon LK, Schirripa O, Horvath S, Braun J, Seligson DB, Wadehra M. PMID: 20578181.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    32. Epithelial membrane protein-2 is a novel therapeutic target in ovarian cancer. Clin Cancer Res. 2010 Aug 01; 16(15):3954-63. Fu M, Maresh EL, Soslow RA, Alavi M, Mah V, Zhou Q, Iasonos A, Goodglick L, Gordon LK, Braun J, Wadehra M. PMID: 20670949.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    33. Functional consequences of interactions between FAK and epithelial membrane protein 2 (EMP2). Invest Ophthalmol Vis Sci. 2009 Oct; 50(10):4949-56. Morales SA, Mareninov S, Coulam P, Wadehra M, Goodglick L, Braun J, Gordon LK. PMID: 19494199.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    34. Blockade of epithelial membrane protein 2 (EMP2) abrogates infection of Chlamydia muridarum murine genital infection model. FEMS Immunol Med Microbiol. 2009 Mar; 55(2):240-9. Shimazaki K, Chan AM, Moniz RJ, Wadehra M, Nagy A, Coulam CP, Mareninov S, Lepin EM, Wu AM, Kelly KA, Braun J, Gordon LK. PMID: 19159428.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    35. Diabodies targeting epithelial membrane protein 2 reduce tumorigenicity of human endometrial cancer cell lines. Clin Cancer Res. 2008 Nov 15; 14(22):7367-77. Shimazaki K, Lepin EJ, Wei B, Nagy AK, Coulam CP, Mareninov S, Fu M, Wu AM, Marks JD, Braun J, Gordon LK, Wadehra M. PMID: 19010852.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    36. FAK activation and the role of epithelial membrane protein 2 (EMP2) in collagen gel contraction. Invest Ophthalmol Vis Sci. 2009 Jan; 50(1):462-9. Morales SA, Mareninov S, Wadehra M, Zhang L, Goodglick L, Braun J, Gordon LK. PMID: 18469192.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    37. Steroid hormone regulation of EMP2 expression and localization in the endometrium. Reprod Biol Endocrinol. 2008 Apr 09; 6:15. Wadehra M, Mainigi M, Morales SA, Rao RG, Gordon LK, Williams CJ, Braun J. PMID: 18400107.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    38. Collagen gel contraction by ARPE-19 cells is mediated by a FAK-Src dependent pathway. Exp Eye Res. 2007 Dec; 85(6):790-8. Morales SA, Mareninov S, Prasad P, Wadehra M, Braun J, Gordon LK. PMID: 17915217.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    39. The tetraspan protein EMP2 regulates expression of caveolin-1. J Biol Chem. 2007 Sep 07; 282(36):26542-51. Forbes A, Wadehra M, Mareninov S, Morales S, Shimazaki K, Gordon LK, Braun J. PMID: 17609206.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    40. Epithelial membrane protein 2 modulates infectivity of Chlamydia muridarum (MoPn). Microbes Infect. 2007 Jul; 9(8):1003-10. Shimazaki K, Wadehra M, Forbes A, Chan AM, Goodglick L, Kelly KA, Braun J, Gordon LK. PMID: 17544801.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    41. Expression of epithelial membrane protein-2 is associated with endometrial adenocarcinoma of unfavorable outcome. Cancer. 2006 Jul 01; 107(1):90-8. Wadehra M, Natarajan S, Seligson DB, Williams CJ, Hummer AJ, Hedvat C, Braun J, Soslow RA. PMID: 16736513.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    42. Knockdown of the tetraspan protein epithelial membrane protein-2 inhibits implantation in the mouse. Dev Biol. 2006 Apr 15; 292(2):430-41. Wadehra M, Dayal M, Mainigi M, Ord T, Iyer R, Braun J, Williams CJ. PMID: 16487956.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    43. Epithelial membrane protein-2 regulates surface expression of alphavbeta3 integrin in the endometrium. Dev Biol. 2005 Nov 15; 287(2):336-45. Wadehra M, Forbes A, Pushkarna N, Goodglick L, Gordon LK, Williams CJ, Braun J. PMID: 16216233.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    44. Identification of genes differentially expressed in rat alveolar type I cells. Am J Respir Cell Mol Biol. 2004 Sep; 31(3):309-16. Dahlin K, Mager EM, Allen L, Tigue Z, Goodglick L, Wadehra M, Dobbs L. PMID: 15205179.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    45. The tetraspan protein EMP2 modulates the surface expression of caveolins and glycosylphosphatidyl inositol-linked proteins. Mol Biol Cell. 2004 May; 15(5):2073-83. Wadehra M, Goodglick L, Braun J. PMID: 14978215.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    46. The tetraspan protein EMP2 increases surface expression of class I major histocompatibility complex proteins and susceptibility to CTL-mediated cell death. Clin Immunol. 2003 May; 107(2):129-36. Wadehra M, Su H, Gordon LK, Goodglick L, Braun J. PMID: 12763482.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    47. Epithelial membrane protein-2 is expressed in discrete anatomical regions of the eye. Exp Mol Pathol. 2003 Apr; 74(2):106-12. Wadehra M, Sulur GG, Braun J, Gordon LK, Goodglick L. PMID: 12710941.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    48. The tetraspan protein epithelial membrane protein-2 interacts with beta1 integrins and regulates adhesion. J Biol Chem. 2002 Oct 25; 277(43):41094-100. Wadehra M, Iyer R, Goodglick L, Braun J. PMID: 12189152.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    49. One-step RT-PCR for screening microdissected tissue samples. Biotechniques. 2002 Feb; 32(2):242, 244, 246, 248. Wadehra M, Braun J, Goodglick L. PMID: 11848395.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    50. Epithelial membrane protein 2, a 4-transmembrane protein that suppresses B-cell lymphoma tumorigenicity. Blood. 2001 Jun 15; 97(12):3890-5. Wang CX, Wadehra M, Fisk BC, Goodglick L, Braun J. PMID: 11389031.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    51. Overexpression of murine fizzy-related (fzr) increases natural killer cell-mediated cell death and suppresses tumor growth. Blood. 2000 Jul 01; 96(1):259-63. Wang CX, Fisk BC, Wadehra M, Su H, Braun J. PMID: 10891459.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
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