Manuel L Penichet

Title(s)Professor, Surgery
SchoolMedicine
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    Other Positions
    Title(s)Professor, MIMG


    Collapse Research 
    Collapse Research Activities and Funding
    A Novel Strategy Targeting TfR1 for the Prevention/Treatment of AIDS-related NHL
    NIH R01CA196266Jan 1, 2016 - Dec 31, 2020
    Role: Principal Investigator
    (PQC3) Immunological Basis of Health Disparities in Multiple Myeloma
    NIH R21CA193953May 1, 2015 - Apr 30, 2018
    Role: Principal Investigator
    A Novel Anti-HER2/neu IgE for Breast Cancer Therapy
    NIH R01CA181115Sep 1, 2014 - Aug 31, 2021
    Role: Principal Investigator
    Novel Nanopolymers to Inhibit Angiogenesis and Increase the Anti-tumor Immunity
    NIH R01CA136841Aug 5, 2010 - May 31, 2015
    Role: Principal Investigator
    Development of an anti-PSA IgE to treat prostate cancer
    NIH R41CA137881May 1, 2009 - Jul 31, 2010
    Role: Co-Principal Investigator
    Anti-TfR IgG3-Av: A New Drug Against Multiple Myeloma
    NIH R01CA107023Dec 20, 2004 - Nov 30, 2010
    Role: Principal Investigator
    Universal Vectors for the Therapy of Cancer
    NIH K01CA086915Apr 1, 2001 - Mar 31, 2007
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Efficacy of Antibodies Targeting TfR1 in Xenograft Mouse Models of AIDS-Related Non-Hodgkin Lymphoma. Cancers (Basel). 2023 Mar 17; 15(6). Daniels-Wells TR, Candelaria PV, Kranz E, Wen J, Wang L, Kamata M, Almagro JC, Martínez-Maza O, Penichet ML. PMID: 36980702; PMCID: PMC10046321.
      View in: PubMed   Mentions:
    2. Follicular CD8+ T Cells Are Elevated in HIV Infection and Induce PD-L1 on B Cells. J Immunol. 2023 01 01; 210(1):33-39. Martínez LE, Ibarrondo J, Guo Y, Penichet ML, Epeldegui M. PMID: 36445393; PMCID: PMC9840893.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Two novel piperidones induce apoptosis and antiproliferative effects on human prostate and lymphoma cancer cell lines. Invest New Drugs. 2022 Oct; 40(5):905-921. Swain RM, Contreras L, Varela-Ramirez A, Hossain M, Das U, Valenzuela CA, Penichet ML, Dimmock JR, Aguilera RJ. PMID: 35793039; PMCID: PMC9896656.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Identification of a Unique Cytotoxic Thieno[2,3-c]Pyrazole Derivative with Potent and Selective Anticancer Effects In Vitro. Biology (Basel). 2022 Jun 18; 11(6). Hess JD, Macias LH, Gutierrez DA, Moran-Santibanez K, Contreras L, Medina S, Villanueva PJ, Kirken RA, Varela-Ramirez A, Penichet ML, Aguilera RJ. PMID: 35741451; PMCID: PMC9219615.
      View in: PubMed   Mentions: 1  
    5. Combination Therapy of an Antibody Specific for Transferrin Receptor 1 (ch128.1/IgG1) With Bortezomib or Lenalidomide Results in Increased Survival in an In Vivo Model of Human Multiple Myeloma: A Brief Communication. J Immunother. 2022 06 01; 45(5):227-230. Candelaria PV, Nava M, Martínez-Maza O, Daniels-Wells TR, Penichet ML. PMID: 35467582; PMCID: PMC9153518.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    6. Host receptor-targeted therapeutic approach to counter pathogenic New World mammarenavirus infections. Nat Commun. 2022 01 28; 13(1):558. Hickerson BT, Daniels-Wells TR, Payes C, Clark LE, Candelaria PV, Bailey KW, Sefing EJ, Zink S, Ziegenbein J, Abraham J, Helguera G, Penichet ML, Gowen BB. PMID: 35091550; PMCID: PMC8799657.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    7. IgE-Based Therapeutic Combination Enhances Antitumor Response in Preclinical Models of Pancreatic Cancer. Mol Cancer Ther. 2021 12; 20(12):2457-2468. Markov SD, Caffrey TC, O'Connell KA, Grunkemeyer JA, Shin S, Hanson R, Patil PP, Shukla SK, Gonzalez D, Crawford AJ, Vance KE, Huang Y, Eberle KC, Radhakrishnan P, Grandgenett PM, Singh PK, Madiyalakan R, Daniels-Wells TR, Penichet ML, Nicodemus CF, Poole JA, Jaffee EM, Hollingsworth MA, Mehla K. PMID: 34625505; PMCID: PMC8762606.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    8. Targeting TfR1 with the ch128.1/IgG1 Antibody Inhibits EBV-driven Lymphomagenesis in Immunosuppressed Mice Bearing EBV+ Human Primary B-cells. Mol Cancer Ther. 2021 09; 20(9):1592-1602. Martínez LE, Daniels-Wells TR, Guo Y, Magpantay LI, Candelaria PV, Penichet ML, Martínez-Maza O, Epeldegui M. PMID: 34158342; PMCID: PMC8419068.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    9. Antibodies Targeting the Transferrin Receptor 1 (TfR1) as Direct Anti-cancer Agents. Front Immunol. 2021; 12:607692. Candelaria PV, Leoh LS, Penichet ML, Daniels-Wells TR. PMID: 33815364; PMCID: PMC8010148.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    10. Author Correction: Blood-brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy. Nat Commun. 2020 Nov 26; 11(1):6170. Galstyan A, Markman JL, Shatalova ES, Chiechi A, Korman AJ, Patil R, Klymyshyn D, Tourtellotte WG, Israel LL, Braubach O, Ljubimov VA, Mashouf LA, Ramesh A, Grodzinski ZB, Penichet ML, Black KL, Holler E, Sun T, Ding H, Ljubimov AV, Ljubimova JY. PMID: 33243989; PMCID: PMC7692458.
      View in: PubMed   Mentions: 3     Fields:    
    11. Immunogenicity and antitumor efficacy of a novel human PD-1 B-cell vaccine (PD1-Vaxx) and combination immunotherapy with dual trastuzumab/pertuzumab-like HER-2 B-cell epitope vaccines (B-Vaxx) in a syngeneic mouse model. Oncoimmunology. 2020 10 01; 9(1):1818437. Kaumaya PTP, Guo L, Overholser J, Penichet ML, Bekaii-Saab T. PMID: 33117602; PMCID: PMC7553530.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    12. Type I interferon underlies severe disease associated with Junín virus infection in mice. Elife. 2020 05 26; 9. Hickerson BT, Sefing EJ, Bailey KW, Van Wettere AJ, Penichet ML, Gowen BB. PMID: 32452770; PMCID: PMC7297529.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    13. An IgG1 Version of the Anti-transferrin Receptor 1 Antibody ch128.1 Shows Significant Antitumor Activity Against Different Xenograft Models of Multiple Myeloma: A Brief Communication. J Immunother. 2020 Feb/Mar; 43(2):48-52. Daniels-Wells TR, Candelaria PV, Leoh LS, Nava M, Martínez-Maza O, Penichet ML. PMID: 31693515; PMCID: PMC7002290.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    14. Author Correction: Blood-brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy. Nat Commun. 2020 Jan 30; 11(1):701. Galstyan A, Markman JL, Shatalova ES, Chiechi A, Korman AJ, Patil R, Klymyshyn D, Tourtellotte WG, Israel LL, Braubach O, Ljubimov VA, Mashouf LA, Ramesh A, Grodzinski ZB, Penichet ML, Black KL, Holler E, Sun T, Ding H, Ljubimov AV, Ljubimova JY. PMID: 32001685; PMCID: PMC6992611.
      View in: PubMed   Mentions:    Fields:    
    15. Author Correction: Elevated numbers of PD-L1 expressing B cells are associated with the development of AIDS-NHL. Sci Rep. 2020 Jan 15; 10(1):748. Epeldegui M, Conti DV, Guo Y, Cozen W, Penichet ML, Martínez-Maza O. PMID: 31937870; PMCID: PMC6960160.
      View in: PubMed   Mentions:    Fields:    
    16. Blood-brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy. Nat Commun. 2019 08 28; 10(1):3850. Galstyan A, Markman JL, Shatalova ES, Chiechi A, Korman AJ, Patil R, Klymyshyn D, Tourtellotte WG, Israel LL, Braubach O, Ljubimov VA, Mashouf LA, Ramesh A, Grodzinski ZB, Penichet ML, Black KL, Holler E, Sun T, Ding H, Ljubimov AV, Ljubimova JY. PMID: 31462642; PMCID: PMC6713723.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansAnimalsCells
    17. Elevated numbers of PD-L1 expressing B cells are associated with the development of AIDS-NHL. Sci Rep. 2019 06 28; 9(1):9371. Epeldegui M, Conti DV, Guo Y, Cozen W, Penichet ML, Martínez-Maza O. PMID: 31253857; PMCID: PMC6599055.
      View in: PubMed   Mentions: 11     Fields:    
    18. Amino acid residues involved in the heparin-binding activity of murine IL-12 in the context of an antibody-cytokine fusion protein. Cytokine. 2019 08; 120:220-226. Luria-Pérez R, Candelaria PV, Daniels-Wells TR, Rodríguez JA, Helguera G, Penichet ML. PMID: 31121497; PMCID: PMC7007190.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    19. AllergoOncology: Microbiota in allergy and cancer-A European Academy for Allergy and Clinical Immunology position paper. Allergy. 2019 06; 74(6):1037-1051. Untersmayr E, Bax HJ, Bergmann C, Bianchini R, Cozen W, Gould HJ, Hartmann K, Josephs DH, Levi-Schaffer F, Penichet ML, O'Mahony L, Poli A, Redegeld FA, Roth-Walter F, Turner MC, Vangelista L, Karagiannis SN, Jensen-Jarolim E. PMID: 30636005; PMCID: PMC6563061.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    20. Human Mast Cells From Adipose Tissue Target and Induce Apoptosis of Breast Cancer Cells. Front Immunol. 2019; 10:138. Plotkin JD, Elias MG, Fereydouni M, Daniels-Wells TR, Dellinger AL, Penichet ML, Kepley CL. PMID: 30833944; PMCID: PMC6387946.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    21. Blockade of a Laminin-411-Notch Axis with CRISPR/Cas9 or a Nanobioconjugate Inhibits Glioblastoma Growth through Tumor-Microenvironment Cross-talk. Cancer Res. 2019 03 15; 79(6):1239-1251. Sun T, Patil R, Galstyan A, Klymyshyn D, Ding H, Chesnokova A, Cavenee WK, Furnari FB, Ljubimov VA, Shatalova ES, Wagner S, Li D, Mamelak AN, Bannykh SI, Patil CG, Rudnick JD, Hu J, Grodzinski ZB, Rekechenetskiy A, Falahatian V, Lyubimov AV, Chen YL, Leoh LS, Daniels-Wells TR, Penichet ML, Holler E, Ljubimov AV, Black KL, Ljubimova JY. PMID: 30659021; PMCID: PMC6625517.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    22. Efficacy and Mechanism of Antitumor Activity of an Antibody Targeting Transferrin Receptor 1 in Mouse Models of Human Multiple Myeloma. J Immunol. 2018 05 15; 200(10):3485-3494. Leoh LS, Kim YK, Candelaria PV, Martínez-Maza O, Daniels-Wells TR, Penichet ML. PMID: 29654211; PMCID: PMC6042853.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    23. Virus-like particle display of HER2 induces potent anti-cancer responses. Oncoimmunology. 2018; 7(3):e1408749. Palladini A, Thrane S, Janitzek CM, Pihl J, Clemmensen SB, de Jongh WA, Clausen TM, Nicoletti G, Landuzzi L, Penichet ML, Balboni T, Ianzano ML, Giusti V, Theander TG, Nielsen MA, Salanti A, Lollini PL, Nanni P, Sander AF. PMID: 29399414; PMCID: PMC5790387.
      View in: PubMed   Mentions: 49     Fields:    
    24. Progress and Challenges in the Design and Clinical Development of Antibodies for Cancer Therapy. Front Immunol. 2017; 8:1751. Almagro JC, Daniels-Wells TR, Perez-Tapia SM, Penichet ML. PMID: 29379493; PMCID: PMC5770808.
      View in: PubMed   Mentions: 66     Fields:    
    25. Corrigendum to "Insights into the effector functions of human IgG3 in the context of an antibody targeting transferrin receptor 1" [Mol. Immunol. 67 (2015) 407-415]. Mol Immunol. 2016 12; 80:101. Leoh LS, Daniels-Wells TR, Martínez-Maza O, Penichet ML. PMID: 27838011.
      View in: PubMed   Mentions:    Fields:    
    26. Cytotoxic Properties of a DEPTOR-mTOR Inhibitor in Multiple Myeloma Cells. Cancer Res. 2016 10 01; 76(19):5822-5831. Shi Y, Daniels-Wells TR, Frost P, Lee J, Finn RS, Bardeleben C, Penichet ML, Jung ME, Gera J, Lichtenstein A. PMID: 27530328; PMCID: PMC5100807.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    27. Transferrin receptor 1: a target for antibody-mediated cancer therapy. Immunotherapy. 2016 09; 8(9):991-4. Daniels-Wells TR, Penichet ML. PMID: 27373880.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    28. Breast cancers from black women exhibit higher numbers of immunosuppressive macrophages with proliferative activity and of crown-like structures associated with lower survival compared to non-black Latinas and Caucasians. Breast Cancer Res Treat. 2016 07; 158(1):113-126. Koru-Sengul T, Santander AM, Miao F, Sanchez LG, Jorda M, Glück S, Ince TA, Nadji M, Chen Z, Penichet ML, Cleary MP, Torroella-Kouri M. PMID: 27283835; PMCID: PMC5129629.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    29. Efficacy of an Anti-transferrin Receptor 1 Antibody Against AIDS-related Non-Hodgkin Lymphoma: A Brief Communication. J Immunother. 2015 Oct; 38(8):307-10. Daniels-Wells TR, Widney DP, Leoh LS, Martínez-Maza O, Penichet ML. PMID: 26325374; PMCID: PMC4592199.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    30. Insights into the effector functions of human IgG3 in the context of an antibody targeting transferrin receptor 1. Mol Immunol. 2015 Oct; 67(2 Pt B):407-15. Leoh LS, Daniels-Wells TR, Martínez-Maza O, Penichet ML. PMID: 26232328; PMCID: PMC4636009.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    31. Non-invasive gene targeting to the fetal brain after intravenous administration and transplacental transfer of plasmid DNA using PEGylated immunoliposomes. J Drug Target. 2016; 24(1):58-67. Cornford EM, Hyman S, Cornford ME, Chytrova G, Rhee J, Suzuki T, Yamagata T, Yamakawa K, Penichet ML, Pardridge WM. PMID: 26133964.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    32. IgE immunotherapy against cancer. Curr Top Microbiol Immunol. 2015; 388:109-49. Leoh LS, Daniels-Wells TR, Penichet ML. PMID: 25553797; PMCID: PMC4452505.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsPHPublic Health
    33. Vaccines against human HER2 prevent mammary carcinoma in mice transgenic for human HER2. Breast Cancer Res. 2014 Jan 23; 16(1):R10. De Giovanni C, Nicoletti G, Quaglino E, Landuzzi L, Palladini A, Ianzano ML, Dall'Ora M, Grosso V, Ranieri D, Laranga R, Croci S, Amici A, Penichet ML, Iezzi M, Cavallo F, Nanni P, Lollini PL. PMID: 24451168; PMCID: PMC3979148.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    34. Rationale and preclinical efficacy of a novel anti-EMP2 antibody for the treatment of invasive breast cancer. Mol Cancer Ther. 2014 Apr; 13(4):902-15. Fu M, Maresh EL, Helguera GF, Kiyohara M, Qin Y, Ashki N, Daniels-Wells TR, Aziz N, Gordon LK, Braun J, Elshimali Y, Soslow RA, Penichet ML, Goodglick L, Wadehra M. PMID: 24448822; PMCID: PMC4034757.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    35. Gene delivery in malignant B cells using the combination of lentiviruses conjugated to anti-transferrin receptor antibodies and an immunoglobulin promoter. J Gene Med. 2014 Jan-Feb; 16(1-2):11-27. Leoh LS, Morizono K, Kershaw KM, Chen IS, Penichet ML, Daniels-Wells TR. PMID: 24436117; PMCID: PMC4051223.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    36. Levels of murine, but not human, CXCL13 are greatly elevated in NOD-SCID mice bearing the AIDS-associated Burkitt lymphoma cell line, 2F7. PLoS One. 2013; 8(8):e72414. Widney DP, Olafsen T, Wu AM, Kitchen CM, Said JW, Smith JB, Peña G, Magpantay LI, Penichet ML, Martinez-Maza O. PMID: 23936541; PMCID: PMC3732224.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    37. Polymalic acid nanobioconjugate for simultaneous immunostimulation and inhibition of tumor growth in HER2/neu-positive breast cancer. J Control Release. 2013 Nov 10; 171(3):322-9. Ding H, Helguera G, Rodríguez JA, Markman J, Luria-Pérez R, Gangalum P, Portilla-Arias J, Inoue S, Daniels-Wells TR, Black K, Holler E, Penichet ML, Ljubimova JY. PMID: 23770212; PMCID: PMC3971991.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    38. A novel IgE antibody targeting the prostate-specific antigen as a potential prostate cancer therapy. BMC Cancer. 2013 Apr 17; 13:195. Daniels-Wells TR, Helguera G, Leuchter RK, Quintero R, Kozman M, Rodríguez JA, Ortiz-Sánchez E, Martínez-Maza O, Schultes BC, Nicodemus CF, Penichet ML. PMID: 23594731; PMCID: PMC3651304.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    39. Iron in multiple myeloma. Crit Rev Oncog. 2013; 18(5):449-61. VanderWall K, Daniels-Wells TR, Penichet M, Lichtenstein A. PMID: 23879589; PMCID: PMC3741338.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    40. Insights into the mechanism of cell death induced by saporin delivered into cancer cells by an antibody fusion protein targeting the transferrin receptor 1. Toxicol In Vitro. 2013 Feb; 27(1):220-31. Daniels-Wells TR, Helguera G, Rodríguez JA, Leoh LS, Erb MA, Diamante G, Casero D, Pellegrini M, Martínez-Maza O, Penichet ML. PMID: 23085102; PMCID: PMC3513587.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    41. Pomegranate juice and specific components inhibit cell and molecular processes critical for metastasis of breast cancer. Breast Cancer Res Treat. 2012 Dec; 136(3):647-58. Rocha A, Wang L, Penichet M, Martins-Green M. PMID: 23065001.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    42. TRAF6 activation in multiple myeloma: a potential therapeutic target. Clin Lymphoma Myeloma Leuk. 2012 Jun; 12(3):155-63. Liu H, Tamashiro S, Baritaki S, Penichet M, Yu Y, Chen H, Berenson J, Bonavida B. PMID: 22440007; PMCID: PMC3799862.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    43. An antibody recognizing the apical domain of human transferrin receptor 1 efficiently inhibits the entry of all new world hemorrhagic Fever arenaviruses. J Virol. 2012 Apr; 86(7):4024-8. Helguera G, Jemielity S, Abraham J, Cordo SM, Martinez MG, Rodríguez JA, Bregni C, Wang JJ, Farzan M, Penichet ML, Candurra NA, Choe H. PMID: 22278244; PMCID: PMC3302512.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    44. Animal models for IgE-meditated cancer immunotherapy. Cancer Immunol Immunother. 2012 Sep; 61(9):1535-46. Daniels TR, Martínez-Maza O, Penichet ML. PMID: 22193986; PMCID: PMC3718027.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    45. Targeting HER2/neu with a fully human IgE to harness the allergic reaction against cancer cells. Cancer Immunol Immunother. 2012 Jul; 61(7):991-1003. Daniels TR, Leuchter RK, Quintero R, Helguera G, Rodríguez JA, Martínez-Maza O, Schultes BC, Nicodemus CF, Penichet ML. PMID: 22127364; PMCID: PMC3719406.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    46. The vitamin E analog, alpha-tocopheryloxyacetic acid enhances the anti-tumor activity of trastuzumab against HER2/neu-expressing breast cancer. BMC Cancer. 2011 Nov 02; 11:471. Hahn T, Bradley-Dunlop DJ, Hurley LH, Von-Hoff D, Gately S, Mary DL, Lu H, Penichet ML, Besselsen DG, Cole BB, Meeuwsen T, Walker E, Akporiaye ET. PMID: 22044845; PMCID: PMC3217981.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    47. Lethal iron deprivation induced by non-neutralizing antibodies targeting transferrin receptor 1 in malignant B cells. Leuk Lymphoma. 2011 Nov; 52(11):2169-78. Rodríguez JA, Luria-Pérez R, López-Valdés HE, Casero D, Daniels TR, Patel S, Avila D, Leuchter R, So S, Ortiz-Sánchez E, Bonavida B, Martínez-Maza O, Charles AC, Pellegrini M, Helguera G, Penichet ML. PMID: 21870996; PMCID: PMC3732792.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    48. The transferrin receptor and the targeted delivery of therapeutic agents against cancer. Biochim Biophys Acta. 2012 Mar; 1820(3):291-317. Daniels TR, Bernabeu E, Rodríguez JA, Patel S, Kozman M, Chiappetta DA, Holler E, Ljubimova JY, Helguera G, Penichet ML. PMID: 21851850; PMCID: PMC3500658.
      View in: PubMed   Mentions: 227     Fields:    Translation:Humans
    49. An antibody-based multifaceted approach targeting the human transferrin receptor for the treatment of B-cell malignancies. J Immunother. 2011 Jul-Aug; 34(6):500-8. Daniels TR, Ortiz-Sánchez E, Luria-Pérez R, Quintero R, Helguera G, Bonavida B, Martínez-Maza O, Penichet ML. PMID: 21654517; PMCID: PMC3717268.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    50. Unique Pattern of Overexpression of Raf-1 Kinase Inhibitory Protein in Its Inactivated Phosphorylated Form in Human Multiple Myeloma. For Immunopathol Dis Therap. 2011 Apr 01; 2(2). Baritaki S, Huerta-Yepez S, Cabrava-Haimandez MD, Sensi M, Canevari S, Libra M, Penichet M, Chen H, Berenson JR, Bonavida B. PMID: 24286018; PMCID: PMC3839863.
      View in: PubMed   Mentions: 12  
    51. Visualization and quantification of cytotoxicity mediated by antibodies using imaging flow cytometry. J Immunol Methods. 2011 May 31; 368(1-2):54-63. Helguera G, Rodríguez JA, Luria-Pérez R, Henery S, Catterton P, Bregni C, George TC, Martínez-Maza O, Penichet ML. PMID: 21420412.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    52. Polymalic acid-based nanobiopolymer provides efficient systemic breast cancer treatment by inhibiting both HER2/neu receptor synthesis and activity. Cancer Res. 2011 Feb 15; 71(4):1454-64. Inoue S, Ding H, Portilla-Arias J, Hu J, Konda B, Fujita M, Espinoza A, Suhane S, Riley M, Gates M, Patil R, Penichet ML, Ljubimov AV, Black KL, Holler E, Ljubimova JY. PMID: 21303974; PMCID: PMC3428373.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    53. Decreased survival of human breast cancer cells expressing HER2/neu on in vitro incubation with an anti-HER2/neu antibody fused to C5a or C5a desArg. Mol Cancer Ther. 2010 Aug; 9(8):2175-85. Fuenmayor J, Perez-Vazquez K, Perez-Witzke D, Penichet ML, Montano RF. PMID: 20682652.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    54. The effect of Chlamydophila pneumoniae Major Outer Membrane Protein (MOMP) on macrophage and T cell-mediated immune responses. Immunobiology. 2011 Jan-Feb; 216(1-2):152-63. Bermudez-Fajardo A, Stark AK, El-Kadri R, Penichet ML, Hölzle K, Wittenbrink MM, Hölzle L, Oviedo-Orta E. PMID: 20637522.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    55. Inhibition of NF-kappaB and Akt pathways by an antibody-avidin fusion protein sensitizes malignant B-cells to cisplatin-induced apoptosis. Int J Oncol. 2010 May; 36(5):1299-307. Suzuki E, Daniels TR, Helguera G, Penichet ML, Umezawa K, Bonavida B. PMID: 20372806; PMCID: PMC3732793.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    56. Propulsion of African trypanosomes is driven by bihelical waves with alternating chirality separated by kinks. Proc Natl Acad Sci U S A. 2009 Nov 17; 106(46):19322-7. Rodríguez JA, Lopez MA, Thayer MC, Zhao Y, Oberholzer M, Chang DD, Kisalu NK, Penichet ML, Helguera G, Bruinsma R, Hill KL, Miao J. PMID: 19880745; PMCID: PMC2780783.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    57. A versatile targeting system with lentiviral vectors bearing the biotin-adaptor peptide. J Gene Med. 2009 Aug; 11(8):655-63. Morizono K, Xie Y, Helguera G, Daniels TR, Lane TF, Penichet ML, Chen IS. PMID: 19455593; PMCID: PMC2834590.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    58. Leptin-signaling inhibition results in efficient anti-tumor activity in estrogen receptor positive or negative breast cancer. Breast Cancer Res. 2009; 11(3):R36. Rene Gonzalez R, Watters A, Xu Y, Singh UP, Mann DR, Rueda BR, Penichet ML. PMID: 19531256; PMCID: PMC2716504.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    59. Characterisation of an engineered trastuzumab IgE antibody and effector cell mechanisms targeting HER2/neu-positive tumour cells. Cancer Immunol Immunother. 2009 Jun; 58(6):915-30. Karagiannis P, Singer J, Hunt J, Gan SK, Rudman SM, Mechtcheriakova D, Knittelfelder R, Daniels TR, Hobson PS, Beavil AJ, Spicer J, Nestle FO, Penichet ML, Gould HJ, Jensen-Jarolim E, Karagiannis SN. PMID: 18941743; PMCID: PMC3017872.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    60. Recombinant polymeric IgG anti-Rh: a novel strategy for development of direct agglutinating reagents. J Immunol Methods. 2009 Jan 01; 340(1):1-10. Montano RF, Penichet ML, Blackall DP, Morrison SL, Chintalacharuvu KR. PMID: 18848836.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    61. Antibody-cytokine fusion proteins: applications in cancer therapy. Expert Opin Biol Ther. 2008 May; 8(5):609-32. Ortiz-Sánchez E, Helguera G, Daniels TR, Penichet ML. PMID: 18407765; PMCID: PMC4535341.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    62. Inhibition of Yin Yang 1-dependent repressor activity of DR5 transcription and expression by the novel proteasome inhibitor NPI-0052 contributes to its TRAIL-enhanced apoptosis in cancer cells. J Immunol. 2008 May 01; 180(9):6199-210. Baritaki S, Suzuki E, Umezawa K, Spandidos DA, Berenson J, Daniels TR, Penichet ML, Jazirehi AR, Palladino M, Bonavida B. PMID: 18424742; PMCID: PMC3747671.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    63. A chaperone protein-enriched tumor cell lysate vaccine generates protective humoral immunity in a mouse breast cancer model. Mol Cancer Ther. 2008 Mar; 7(3):721-9. Li G, Andreansky S, Helguera G, Sepassi M, Janikashvili N, Cantrell J, Lacasse CL, Larmonier N, Penichet ML, Katsanis E. PMID: 18347157.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    64. Antigen-induced immunomodulation in the pathogenesis of atherosclerosis. Clin Dev Immunol. 2008; 2008:723539. Milioti N, Bermudez-Fajardo A, Penichet ML, Oviedo-Orta E. PMID: 18551190; PMCID: PMC2423423.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    65. Conjugation of an anti transferrin receptor IgG3-avidin fusion protein with biotinylated saporin results in significant enhancement of its cytotoxicity against malignant hematopoietic cells. Mol Cancer Ther. 2007 Nov; 6(11):2995-3008. Daniels TR, Ng PP, Delgado T, Lynch MR, Schiller G, Helguera G, Penichet ML. PMID: 18025284.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    66. Binding specificity and internalization properties of an antibody-avidin fusion protein targeting the human transferrin receptor. J Control Release. 2007 Dec 04; 124(1-2):35-42. Rodríguez JA, Helguera G, Daniels TR, Neacato II, López-Valdés HE, Charles AC, Penichet ML. PMID: 17884229.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    67. Brain tumor tandem targeting using a combination of monoclonal antibodies attached to biopoly(beta-L-malic acid). J Control Release. 2007 Oct 08; 122(3):356-63. Fujita M, Lee BS, Khazenzon NM, Penichet ML, Wawrowsky KA, Patil R, Ding H, Holler E, Black KL, Ljubimova JY. PMID: 17630012; PMCID: PMC2394675.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    68. Long-term immunity elicited by antibody-cytokine fusion proteins protects against sequential challenge with murine mammary and colon malignancies. Cancer Immunol Immunother. 2007 Sep; 56(9):1507-12. Helguera G, Rodríguez JA, Daniels TR, Penichet ML. PMID: 17310381.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    69. Targeting aurora kinases as therapy in multiple myeloma. Blood. 2007 May 01; 109(9):3915-21. Shi Y, Reiman T, Li W, Maxwell CA, Sen S, Pilarski L, Daniels TR, Penichet ML, Feldman R, Lichtenstein A. PMID: 17213289; PMCID: PMC1874561.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCellsCTClinical Trials
    70. The transferrin receptor part II: targeted delivery of therapeutic agents into cancer cells. Clin Immunol. 2006 Nov; 121(2):159-76. Daniels TR, Delgado T, Helguera G, Penichet ML. PMID: 16920030.
      View in: PubMed   Mentions: 157     Fields:    Translation:Humans
    71. The transferrin receptor part I: Biology and targeting with cytotoxic antibodies for the treatment of cancer. Clin Immunol. 2006 Nov; 121(2):144-58. Daniels TR, Delgado T, Rodriguez JA, Helguera G, Penichet ML. PMID: 16904380.
      View in: PubMed   Mentions: 228     Fields:    Translation:HumansAnimalsCells
    72. Molecular events contributing to cell death in malignant human hematopoietic cells elicited by an IgG3-avidin fusion protein targeting the transferrin receptor. Blood. 2006 Oct 15; 108(8):2745-54. Ng PP, Helguera G, Daniels TR, Lomas SZ, Rodriguez JA, Schiller G, Bonavida B, Morrison SL, Penichet ML. PMID: 16804109; PMCID: PMC1895578.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    73. Cytokines fused to antibodies and their combinations as therapeutic agents against different peritoneal HER2/neu expressing tumors. Mol Cancer Ther. 2006 Apr; 5(4):1029-40. Helguera G, Rodríguez JA, Penichet ML. PMID: 16648575.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    74. Anti-HER2/neu IgG3-(IL-2) and anti-HER2/neu IgG3-(GM-CSF) promote HER2/neu processing and presentation by dendritic cells: implications in immunotherapy and vaccination strategies. Mol Immunol. 2006 Feb; 43(6):667-76. Dela Cruz JS, Trinh KR, Chen HW, Ribas A, Morrison SL, Penichet ML. PMID: 15908002.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCellsPHPublic Health
    75. Insights into the mechanism of anti-tumor immunity in mice vaccinated with the human HER2/neu extracellular domain plus anti-HER2/neu IgG3-(IL-2) or anti-HER2/neu IgG3-(GM-CSF) fusion protein. Vaccine. 2005 Sep 15; 23(39):4793-803. Dela Cruz JS, Morrison SL, Penichet ML. PMID: 15967544.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    76. Vaccination with novel combinations of anti-HER2/neu cytokines fusion proteins and soluble protein antigen elicits a protective immune response against HER2/neu expressing tumors. Vaccine. 2006 Jan 16; 24(3):304-16. Helguera G, Dela Cruz JS, Lowe C, Ng PP, Trinh R, Morrison SL, Penichet ML. PMID: 16125282.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    77. Enhanced inhibition of murine tumor and human breast tumor xenografts using targeted delivery of an antibody-endostatin fusion protein. Mol Cancer Ther. 2005 Jun; 4(6):956-67. Cho HM, Rosenblatt JD, Kang YS, Iruela-Arispe ML, Morrison SL, Penichet ML, Kwon YG, Kim TW, Webster KA, Nechustan H, Shin SU. PMID: 15956253.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    78. Antibody-cytokine fusion proteins for the therapy of cancer. Methods Mol Med. 2005; 109:347-74. Helguera G, Penichet ML. PMID: 15585931.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    79. A human biotin acceptor domain allows site-specific conjugation of an enzyme to an antibody-avidin fusion protein for targeted drug delivery. Biomol Eng. 2005 Feb; 21(6):145-55. Asai T, Trinh R, Ng PP, Penichet ML, Wims LA, Morrison SL. PMID: 15748688.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    80. Protein vaccination with the HER2/neu extracellular domain plus anti-HER2/neu antibody-cytokine fusion proteins induces a protective anti-HER2/neu immune response in mice. Vaccine. 2003 Mar 28; 21(13-14):1317-26. Dela Cruz JS, Lau SY, Ramirez EM, De Giovanni C, Forni G, Morrison SL, Penichet ML. PMID: 12615426.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCellsPHPublic Health
    81. An anti-transferrin receptor-avidin fusion protein exhibits both strong proapoptotic activity and the ability to deliver various molecules into cancer cells. Proc Natl Acad Sci U S A. 2002 Aug 06; 99(16):10706-11. Ng PP, Dela Cruz JS, Sorour DN, Stinebaugh JM, Shin SU, Shin DS, Morrison SL, Penichet ML. PMID: 12149472; PMCID: PMC125019.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    82. Myeloma expression systems. J Immunol Methods. 2002 Mar 01; 261(1-2):1-20. Yoo EM, Chintalacharuvu KR, Penichet ML, Morrison SL. PMID: 11861062.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
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