Marta Epeldegui

Title(s)	Associate Professor-in-Residence, Obstetrics and Gynecology
School	Medicine
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Research

Research Activities and Funding

The Role of Follicular CD8+ T Cells in Pathogenesis of AIDS-NHL.
NIH R01CA228157Aug 1, 2019 - Jul 31, 2024
Role: Principal Investigator

PDL1 expression on B cells: a potential marker of pre-tumor cells in AIDS-NHL
NIH R21CA220475Jul 1, 2017 - May 31, 2020
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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Predictive Value of Serum Biomarkers for Response of Limited-Stage AIDS-Associated Kaposi Sarcoma to Antiretroviral Therapy With or Without Concomitant Chemotherapy in Resource-Limited Settings. J Acquir Immune Defic Syndr. 2023 10 01; 94(2):165-173. Epeldegui M, Chang D, Lee J, Magpantay LI, Borok M, Bukuru A, Busakhala N, Godfrey C, Hosseinipour MC, Kang M, Kanyama C, Langat D, Mngqibisa R, Mwelase N, Nyirenda M, Samaneka W, Hoagland B, Campbell TB, Martínez-Maza O, Krown SE, A5264/AMC-067 team. PMID: 37368929; PMCID: PMC10527582.

View in: PubMed Mentions: Fields:
Acq Acquired Immunodeficiency Synd
Translation:Humans
Extracellular vesicles as biomarkers for AIDS-associated non-Hodgkin lymphoma risk. Front Immunol. 2023; 14:1259007. Martínez LE, Magpantay LI, Guo Y, Hegde P, Detels R, Hussain SK, Epeldegui M. PMID: 37809067; PMCID: PMC10556683.

View in: PubMed Mentions: Fields:
All Allergy and Immunology
Translation:Humans Cells
Circulating markers of microbial translocation and host response to bacteria with risk of colorectal cancer: a prospective, nested case-control study in men. EBioMedicine. 2023 May; 91:104566. Shi M, Zong X, Hur J, Birmann BM, Martinez-Maza O, Epeldegui M, Chan AT, Giovannucci EL, Cao Y. PMID: 37075493; PMCID: PMC10131057.

View in: PubMed Mentions: 3 Fields:
Gen Genetics Med Medicine (General)
Translation:Humans Cells
Immunization of Mice with Virus-Like Vesicles of Kaposi Sarcoma-Associated Herpesvirus Reveals a Role for Antibodies Targeting ORF4 in Activating Complement-Mediated Neutralization. J Virol. 2023 02 28; 97(2):e0160022. Lam AK, Roshan R, Miley W, Labo N, Zhen J, Kurland AP, Cheng C, Huang H, Teng PL, Harelson C, Gong D, Tam YK, Radu CG, Epeldegui M, Johnson JR, Zhou ZH, Whitby D, Wu TT. PMID: 36757205; PMCID: PMC9972917.

View in: PubMed Mentions: Fields:
Vir Virology
Translation:Humans Animals Cells PHPublic Health
Characterization of T Follicular Helper Cells and T Follicular Regulatory Cells in HIV-Infected and Sero-Negative Individuals. Cells. 2023 01 12; 12(2). Salvatore B, Resop RS, Gordon BR, Epeldegui M, Martinez-Maza O, Comin-Anduix B, Lam A, Wu TT, Uittenbogaart CH. PMID: 36672230; PMCID: PMC9856637.

View in: PubMed Mentions: Fields:
Bio Biophysics Cel Cell Biology Mol Molecular Biology
Translation:Humans Cells
Follicular CD8+ T Cells Are Elevated in HIV Infection and Induce PD-L1 on B Cells. J Immunol. 2023 01 01; 210(1):33-39. Martínez LE, Ibarrondo J, Guo Y, Penichet ML, Epeldegui M. PMID: 36445393; PMCID: PMC9840893.

View in: PubMed Mentions: 2 Fields:
All Allergy and Immunology
Translation:Humans Cells
Plasma extracellular vesicles bearing PD-L1, CD40, CD40L or TNF-RII are significantly reduced after treatment of AIDS-NHL. Sci Rep. 2022 06 02; 12(1):9185. Martínez LE, Lensing S, Chang D, Magpantay LI, Mitsuyasu R, Ambinder RF, Sparano JA, Martínez-Maza O, Epeldegui M. PMID: 35655072; PMCID: PMC9163074.

View in: PubMed Mentions: 2 Fields:
Sci Science
Translation:Humans Cells
Comparative outcomes for mature T-cell and NK/T-cell lymphomas in people with and without HIV and to AIDS-defining lymphomas. Blood Adv. 2022 03 08; 6(5):1420-1431. Koh MJ, Merrill MH, Koh MJ, Stuver R, Alonso CD, Foss FM, Mayor AM, Gill J, Epeldegui M, Cachay E, Thorne JE, Silverberg MJ, Horberg MA, Althoff KN, Nijhawan AE, McGinnis KA, Lee JS, Rabkin CS, Napravnik S, Li J, Castilho JL, Shen C, Jain S. PMID: 35026839; PMCID: PMC8905704.

View in: PubMed Mentions: Fields:
Hem Hematology
Translation:Humans Cells
HIV-infection and cocaine use regulate semen extracellular vesicles proteome and miRNAome in a manner that mediates strategic monocyte haptotaxis governed by miR-128 network. Cell Mol Life Sci. 2021 Dec 22; 79(1):5. Kaddour H, Kopcho S, Lyu Y, Shouman N, Paromov V, Pratap S, Dash C, Kim EY, Martinson J, McKay H, Epeldegui M, Margolick JB, Stapleton JT, Okeoma CM. PMID: 34936021; PMCID: PMC9134786.

View in: PubMed Mentions: 3 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Humans Cells
CloneRetriever: An Automated Algorithm to Identify Clonal B and T Cell Gene Rearrangements by Next-Generation Sequencing for the Diagnosis of Lymphoid Malignancies. Clin Chem. 2021 11 01; 67(11):1524-1533. Halper-Stromberg E, McCall CM, Haley LM, Lin MT, Vogt S, Gocke CD, Eshleman JR, Stevens W, Martinson NA, Epeldegui M, Holdhoff M, Bettegowda C, Glantz MJ, Ambinder RF, Xian RR. PMID: 34491318; PMCID: PMC8965457.

View in: PubMed Mentions: Fields:
Che Chemistry
Translation:Humans
Lymphoma-Associated Biomarkers Are Increased in Current Smokers in Twin Pairs Discordant for Smoking. Cancers (Basel). 2021 Oct 27; 13(21). Wang J, Conti DV, Epeldegui M, Ollikainen M, Tyndale RF, Hwang AE, Magpantay L, Mack TM, Martinez-Maza O, Kaprio J, Cozen W. PMID: 34771561; PMCID: PMC8582438.

View in: PubMed Mentions:
Host characteristics associated with serologic inflammatory biomarkers in women. Cytokine. 2022 01; 149:155726. Wang SS, Zhong C, Epeldegui M, Nunes S, Magpantay L, DeHart JC, Hurley S, Goldberg D, Martinez E, Lacey JV, Martinez-Maza O, Reynolds P. PMID: 34666235; PMCID: PMC8680201.

View in: PubMed Mentions: 1 Fields:
All Allergy and Immunology
Translation:Humans Cells
Targeting TfR1 with the ch128.1/IgG1 Antibody Inhibits EBV-driven Lymphomagenesis in Immunosuppressed Mice Bearing EBV+ Human Primary B-cells. Mol Cancer Ther. 2021 09; 20(9):1592-1602. Martínez LE, Daniels-Wells TR, Guo Y, Magpantay LI, Candelaria PV, Penichet ML, Martínez-Maza O, Epeldegui M. PMID: 34158342; PMCID: PMC8419068.

View in: PubMed Mentions: 3 Fields:
Ant Antineoplastic Agents
Translation:Humans Animals Cells
Immune Activation and Microbial Translocation as Prognostic Biomarkers for AIDS-Related Non-Hodgkin Lymphoma in the AMC-034 Study. Clin Cancer Res. 2021 08 15; 27(16):4642-4651. Martínez LE, Lensing S, Chang D, Magpantay LI, Mitsuyasu R, Ambinder RF, Sparano JA, Martínez-Maza O, Epeldegui M. PMID: 34131000; PMCID: PMC8364886.

View in: PubMed Mentions: 4 Fields:
Neo Neoplasms
Translation:Humans
Self-Reported Cannabis Use and Markers of Inflammation in Men Who Have Sex With Men With and Without HIV. Cannabis Cannabinoid Res. 2021 04; 6(2):165-173. Krsak M, Wada NI, Plankey MW, Kinney GL, Epeldegui M, Okafor CN, Friedman MR, Palella FJ, Erlandson KM. PMID: 33912681; PMCID: PMC8064959.

View in: PubMed Mentions: 3 Fields:
Pha Pharmacology Psy Psychopharmacology
Translation:Humans Animals
Gut permeability, inflammation, and bone density across the menopause transition. JCI Insight. 2020 01 30; 5(2). Shieh A, Epeldegui M, Karlamangla AS, Greendale GA. PMID: 31830000; PMCID: PMC7098720.

View in: PubMed Mentions: 21 Fields:
Med Medicine (General)
Translation:Humans
Author Correction: Elevated numbers of PD-L1 expressing B cells are associated with the development of AIDS-NHL. Sci Rep. 2020 Jan 15; 10(1):748. Epeldegui M, Conti DV, Guo Y, Cozen W, Penichet ML, Martínez-Maza O. PMID: 31937870; PMCID: PMC6960160.

View in: PubMed Mentions: Fields:
Sci Science
The Role of Microbial Translocation and Immune Activation in AIDS-Associated Non-Hodgkin Lymphoma Pathogenesis: What Have We Learned? Crit Rev Immunol. 2020; 40(1):41-51. Epeldegui M, Hussain SK. PMID: 32421978; PMCID: PMC7241309.

View in: PubMed Mentions: 4 Fields:
All Allergy and Immunology
Translation:Humans Animals Cells
Elevated numbers of PD-L1 expressing B cells are associated with the development of AIDS-NHL. Sci Rep. 2019 06 28; 9(1):9371. Epeldegui M, Conti DV, Guo Y, Cozen W, Penichet ML, Martínez-Maza O. PMID: 31253857; PMCID: PMC6599055.

View in: PubMed Mentions: 12 Fields:
Sci Science
A prospective study of serum microbial translocation biomarkers and risk of AIDS-related non-Hodgkin lymphoma. AIDS. 2018 04 24; 32(7):945-954. Epeldegui M, Magpantay L, Guo Y, Halec G, Cumberland WG, Yen PK, Macatangay B, Margolick JB, Rositch AF, Wolinsky S, Martinez-Maza O, Hussain SK. PMID: 29424776; PMCID: PMC5869109.

View in: PubMed Mentions: 16 Fields:
Acq Acquired Immunodeficiency Synd
Translation:Humans
Urbanization and anticoagulant poisons promote immune dysfunction in bobcats. Proc Biol Sci. 2018 01 31; 285(1871). Serieys LEK, Lea AJ, Epeldegui M, Armenta TC, Moriarty J, VandeWoude S, Carver S, Foley J, Wayne RK, Riley SPD, Uittenbogaart CH. PMID: 29343604; PMCID: PMC5805946.

View in: PubMed Mentions: 14 Fields:
Bio Biology
Translation:Animals
Predictive Value of Cytokines and Immune Activation Biomarkers in AIDS-Related Non-Hodgkin Lymphoma Treated with Rituximab plus Infusional EPOCH (AMC-034 trial). Clin Cancer Res. 2016 Jan 15; 22(2):328-36. Epeldegui M, Lee JY, Martínez AC, Widney DP, Magpantay LI, Regidor D, Mitsuyasu R, Sparano JA, Ambinder RF, Martínez-Maza O. PMID: 26384320; PMCID: PMC4715998.

View in: PubMed Mentions: 10 Fields:
Neo Neoplasms
Translation:Humans CTClinical Trials
Immune Activation: Contribution to AIDS-Associated Non-Hodgkin Lymphoma. For Immunopathol Dis Therap. 2015; 6(1-2):79-90. Epeldegui M, Martínez-Maza O. PMID: 28702272; PMCID: PMC5502768.

View in: PubMed Mentions: 5
BST2/Tetherin is constitutively expressed on human thymocytes with the phenotype and function of Treg cells. Eur J Immunol. 2015 Mar; 45(3):728-37. Epeldegui M, Blom B, Uittenbogaart CH. PMID: 25408362; PMCID: PMC4361012.

View in: PubMed Mentions: 5 Fields:
All Allergy and Immunology
Translation:Humans Cells CTClinical Trials
TLR2-activated B cells are phenotypically similar to the abnormal circulating B cells seen preceding the diagnosis of AIDS-related NHL diagnosis. J Acquir Immune Defic Syndr. 2013 Oct 01; 64(2):204-10. Guo Y, Siewe B, Epeldegui M, Detels R, Landay AL, Martínez-Maza O. PMID: 23722608; PMCID: PMC3778065.

View in: PubMed Mentions: 5 Fields:
Acq Acquired Immunodeficiency Synd
Translation:Humans Cells
IFN-α is constitutively expressed in the human thymus, but not in peripheral lymphoid organs. PLoS One. 2011; 6(8):e24252. Colantonio AD, Epeldegui M, Jesiak M, Jachimowski L, Blom B, Uittenbogaart CH. PMID: 21904619; PMCID: PMC3164161.

View in: PubMed Mentions: 23 Fields:
Med Medicine (General)Sci Science
Translation:Humans Cells
HIV-associated immune dysfunction and viral infection: role in the pathogenesis of AIDS-related lymphoma. Immunol Res. 2010 Dec; 48(1-3):72-83. Epeldegui M, Vendrame E, Martínez-Maza O. PMID: 20717742; PMCID: PMC3640300.

View in: PubMed Mentions: 49 Fields:
All Allergy and Immunology
Translation:Humans Animals Cells
CD40 ligand (CD154) incorporated into HIV virions induces activation-induced cytidine deaminase (AID) expression in human B lymphocytes. PLoS One. 2010 Jul 06; 5(7):e11448. Epeldegui M, Thapa DR, De la Cruz J, Kitchen S, Zack JA, Martínez-Maza O. PMID: 20625427; PMCID: PMC2897846.

View in: PubMed Mentions: 38 Fields:
Med Medicine (General)Sci Science
Translation:Humans Cells
Elevated expression of activation induced cytidine deaminase in peripheral blood mononuclear cells precedes AIDS-NHL diagnosis. AIDS. 2007 Nov 12; 21(17):2265-70. Epeldegui M, Breen EC, Hung YP, Boscardin WJ, Detels R, Martínez-Maza O. PMID: 18090274.

View in: PubMed Mentions: 27 Fields:
Acq Acquired Immunodeficiency Synd
Translation:Humans Cells
Pathogenesis of AIDS lymphoma: role of oncogenic viruses and B cell activation-associated molecular lesions. Curr Opin Oncol. 2006 Sep; 18(5):444-8. Epeldegui M, Widney DP, Martínez-Maza O. PMID: 16894291.

View in: PubMed Mentions: 40 Fields:
Neo Neoplasms
Translation:Humans Cells
Infection of human B cells with Epstein-Barr virus results in the expression of somatic hypermutation-inducing molecules and in the accrual of oncogene mutations. Mol Immunol. 2007 Feb; 44(5):934-42. Epeldegui M, Hung YP, McQuay A, Ambinder RF, Martínez-Maza O. PMID: 16730063.

View in: PubMed Mentions: 36 Fields:
All Allergy and Immunology Mol Molecular Biology
Translation:Humans Cells
Elevated serum soluble CD30 precedes the development of AIDS-associated non-Hodgkin's B cell lymphoma. Tumour Biol. 2006; 27(4):187-94. Breen EC, Fatahi S, Epeldegui M, Boscardin WJ, Detels R, Martínez-Maza O. PMID: 16651853.

View in: PubMed Mentions: 32 Fields:
Neo Neoplasms
Translation:Humans
Elevated levels of soluble CD44 precede the development of AIDS-associated non-Hodgkin's B-cell lymphoma. AIDS. 2005 Oct 14; 19(15):1711-2. Breen EC, Epeldegui M, Boscardin WJ, Widney DP, Detels R, Martínez-Maza O. PMID: 16184051.

View in: PubMed Mentions: 13 Fields:
Acq Acquired Immunodeficiency Synd
Translation:Humans
High exogenous homocysteine modifies eye development in early chick embryos. Birth Defects Res A Clin Mol Teratol. 2003 Jan; 67(1):35-40. Maestro de las Casas C, Epeldegui M, Tudela C, Varela-Moreiras G, Pérez-Miguelsanz J. PMID: 12749382.

View in: PubMed Mentions: 6 Fields:
Ter Teratology
Translation:Animals