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Jing Wen

Title(s)Assistant Adjunct Professor, MIMG
SchoolMedicine
ORCID ORCID Icon0000-0002-6127-6276 Additional info
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    Collapse Biography 
    Collapse education and training
    Dalian University of Technology, Dalian, ChinaB.S.2006Chemical Engineering
    Tianjin University, Tianjin, ChinaPh.D2011Biomedical Engineering
    University of California Los Angeles , Los AngelesPostdoctoral Fellow2016Immunotherapy and gene therapy for HIV
    University of California Los Angeles, Los AngelesProject Scientist 2020Immunotherapy for infectious disease and tumor

    Collapse Overview 
    Collapse overview
    The development of biologics, including protein and gene agents, represents a major advancement towards better therapeutics with high potency and specificity. Their broader adoption, however, has been limited by factors such as undesired biodistribution, low stability, and immunogenicity. The Wen lab focuses on developing advanced biologics through nano-encapsulation and molecule-architecture design that mitigate such limitations, leading to various therapeutics for viral infection, central nervous system diseases (e.g., brain tumor, systemic tumor with brain metastases, and spinal cord injury), and cancers via immune modulation and other pathways.

    Collapse Research 
    Collapse research activities and funding
    Efficient Delivery of Optimized Painless Nerve Growth Factors to the Central Nervous System to Treat Spinal Cord Injuries
    NIH R01NS140655Sep 9, 2025 - Jul 31, 2030
    Role: Sub-award PI
    Improved delivery of bNAbs for targeting CNS infection in infants
    NIH R01NS137919Sep 18, 2024 - Aug 31, 2029
    Role: Principal Investigator
    IIBR Instrumentation: Optomagnetic twisting cytometry (OMTC) for high throghpout mapping of viscoelastic properties of live tissues
    NSF DBI-2345571Jul 1, 2024 - Jun 30, 2027
    Role: Co-principal Investigator
    An antioxidant enzyme to suppress hyperinflammation induced by SARS-CoV-2
    NIH R56AI163386Aug 18, 2022 - Aug 17, 2023
    Role: Principal Investigator
    Pediatric Adolescent Virus Elimination (PAVE) Martin Delaney Collaboratory
    NIH UM1AI164566Aug 16, 2021 - Apr 30, 2026
    Role: Co-Investigator
    Define the effects and mechanism of THC and CBD on IFN-I mediated inflammation and immune dysfunction during HIV infection
    NIH R01DA052841Sep 30, 2020 - Jul 31, 2025
    Role: Co-Investigator
    Targeting delivery of mAbs to CNS metastases
    NIH R01CA253215Aug 1, 2020 - Apr 30, 2025
    Role: Principal Investigator
    (Attack)2: Genetic engineering of cellular and humoral immunity to cure HIV
    NIH U19AI149504May 7, 2020 - Apr 30, 2025
    Role: Co-Investigator
    In Vivo Gene Editing for HIV-1 Cure
    NIH R01AI145038Feb 11, 2019 - Jan 31, 2024
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Potentiating Chemo-Immunotherapy via a Programmable Nanocapsule-Hydrogel Platform for Sequential Tumor Microenvironment Remodeling. Adv Mater. 2026 Feb 01; e22016. Qin X, Wang Y, Feng Y, Yuan H, Tang L, Li F, Cao Z, Chen G, Zhang M, Wen J, Liu C, Lu Y. PMID: 41622807.
      View in: PubMed   Mentions:
    2. A proimmunotoxin nanodrug targeting AIDS-associated non-Hodgkin lymphoma. J Control Release. 2026 Jan 25; 392:114661. Chen S, Qi T, Peng H, Kimura E, Zhang X, Kranz E, Cao Z, Wang Z, Chen W, Ancheta LR, Lappi DA, Chiou PY, Lu Y, Daniels-Wells TR, Penichet ML, Wen J. PMID: 41592623.
      View in: PubMed   Mentions:
    3. Combination Treatment of Rituximab and Therapeutic Vaccines Affords Superior Tumor Suppression and Relapse Prevention for Non-Hodgkin Lymphoma. Adv Mater. 2025 Jul; 37(26):e2502372. Qi T, Guo J, Cao Z, Chen S, Kimura E, Li X, Kranz E, Guo X, Chen W, Wang Z, Wang CY, Lu Y, Wen J. PMID: 40214308; PMCID: PMC12227277.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Large-scale acoustic single cell trapping and selective releasing. Lab Chip. 2025 Mar 11; 25(6):1537-1551. Zhang X, Smith J, Zhou AC, Duong JT, Qi T, Chen S, Lin YJ, Gill A, Lo CH, Lin NYC, Wen J, Lu Y, Chiou PY. PMID: 39901861; PMCID: PMC12335873.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    5. Excision of HIV-1 Provirus in Human Primary Cells with Nanocapsuled TALEN Proteins. ACS Appl Bio Mater. 2025 Feb 17; 8(2):1227-1239. Zhao M, Wen J, Chen ISY, Liu J, Lu Y. PMID: 39889258; PMCID: PMC11892523.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    6. A Multi-Enzyme Nanocascade to Target Disease-Relevant Metabolites. Small. 2025 Jan; 21(2):e2408481. Cao Z, Ren J, Yang A, Wang Z, Love M, Chen W, Yuan X, Guo X, Chen I, Lu Y, Wen J. PMID: 39498716; PMCID: PMC11750155.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    7. Innovative Formulation Platform: Paving the Way for Superior Protein Therapeutics with Enhanced Efficacy and Broadened Applications. Adv Mater. 2024 Oct; 36(41):e2403116. Cao Z, Liu C, Wen J, Lu Y. PMID: 38819929; PMCID: PMC11571700.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    8. Lactate oxidase nanocapsules boost T cell immunity and efficacy of cancer immunotherapy. Sci Transl Med. 2023 10 11; 15(717):eadd2712. Cao Z, Xu D, Harding J, Chen W, Liu X, Wang Z, Wang L, Qi T, Chen S, Guo X, Chen ISY, Guo J, Lu Y, Wen J. PMID: 37820006; PMCID: PMC10720694.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    9. Efficacy of Antibodies Targeting TfR1 in Xenograft Mouse Models of AIDS-Related Non-Hodgkin Lymphoma. Cancers (Basel). 2023 Mar 17; 15(6). Daniels-Wells TR, Candelaria PV, Kranz E, Wen J, Wang L, Kamata M, Almagro JC, Martínez-Maza O, Penichet ML. PMID: 36980702; PMCID: PMC10046321.
      View in: PubMed   Mentions: 3  
    10. Rapid prototyping of functional acoustic devices using laser manufacturing. Lab Chip. 2022 11 08; 22(22):4327-4334. Zhang X, Son R, Lin YJ, Gill A, Chen S, Qi T, Choi D, Wen J, Lu Y, Lin NYC, Chiou PY. PMID: 36285690; PMCID: PMC10122935.
      View in: PubMed   Mentions: 2     Fields:    
    11. Reactive oxygen species associated immunoregulation post influenza virus infection. Front Immunol. 2022; 13:927593. Wang L, Cao Z, Wang Z, Guo J, Wen J. PMID: 35967412; PMCID: PMC9373727.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    12. Targeted Nanocarrier Delivery of RNA Therapeutics to Control HIV Infection. Pharmaceutics. 2022 Jun 26; 14(7). Agbosu EE, Ledger S, Kelleher AD, Wen J, Ahlenstiel CL. PMID: 35890248; PMCID: PMC9324444.
      View in: PubMed   Mentions: 1  
    13. Real-Time Quantification of Cell Internalization Kinetics by Bioluminescent Probes. Methods Mol Biol. 2022; 2525:93-107. Castillo R, Wu D, Cao Z, Yan R, Fajardo K, Ren J, Lu Y, Wen J. PMID: 35836062.
      View in: PubMed   Mentions:    Fields:    
    14. Enzyme Therapeutic for Ischemia and Reperfusion Injury in Organ Transplantation. Adv Mater. 2022 Jan; 34(1):e2105670. Yan R, Ren J, Wen J, Cao Z, Wu D, Qin M, Xu D, Castillo R, Li F, Wang F, Gan Z, Liu C, Wei P, Lu Y. PMID: 34617335.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    15. Improved delivery of broadly neutralizing antibodies by nanocapsules suppresses SHIV infection in the CNS of infant rhesus macaques. PLoS Pathog. 2021 07; 17(7):e1009738. Wen J, Cheever T, Wang L, Wu D, Reed J, Mascola J, Chen X, Liu C, Pegu A, Sacha JB, Lu Y, Haigwood NL, Chen ISY. PMID: 34283885; PMCID: PMC8323878.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    16. Nanoencapsulated rituximab mediates superior cellular immunity against metastatic B-cell lymphoma in a complement competent humanized mouse model. J Immunother Cancer. 2021 02; 9(2). Wen J, Wang L, Ren J, Kranz E, Chen S, Wu D, Kanazawa T, Chen I, Lu Y, Kamata M. PMID: 33593826; PMCID: PMC7888328.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    17. An Antioxidant Enzyme Therapeutic for COVID-19. Adv Mater. 2020 Oct; 32(43):e2004901. Qin M, Cao Z, Wen J, Yu Q, Liu C, Wang F, Zhang J, Yang F, Li Y, Fishbein G, Yan S, Xu B, Hou Y, Ning Z, Nie K, Jiang N, Liu Z, Wu J, Yu Y, Li H, Zheng H, Li J, Jin W, Pang S, Wang S, Chen J, Gan Z, He Z, Lu Y. PMID: 32924219.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    18. The clonal repopulation of HSPC gene modified with anti-HIV-1 RNAi is not affected by preexisting HIV-1 infection. Sci Adv. 2020 07; 6(30):eaay9206. Suryawanshi GW, Khamaikawin W, Wen J, Shimizu S, Arokium H, Xie Y, Wang E, Kim S, Choi H, Zhang C, Yu H, Presson AP, Kim N, An DS, Chen ISY, Kim S. PMID: 32766447; PMCID: PMC7385479.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    19. Enhanced Delivery of Rituximab Into Brain and Lymph Nodes Using Timed-Release Nanocapsules in Non-Human Primates. Front Immunol. 2019; 10:3132. Qin M, Wang L, Wu D, Williams CK, Xu D, Kranz E, Guo Q, Guan J, Vinters HV, Lee Y, Xie Y, Luo Y, Sun G, Sun X, He Z, Lu Y, Kamata M, Wen J, Chen ISY. PMID: 32047498; PMCID: PMC6996053.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    20. Real-Time Quantification of Cell Internalization Kinetics by Functionalized Bioluminescent Nanoprobes. Adv Mater. 2019 Sep; 31(39):e1902469. Wu D, Yang Y, Xu P, Xu D, Liu Y, Castillo R, Yan R, Ren J, Zhou G, Liu C, Qin M, Du J, Hou L, Chen I, Kang C, Jin L, Wen J, Chen W, Lu Y. PMID: 31402525.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    21. Sustained delivery and molecular targeting of a therapeutic monoclonal antibody to metastases in the central nervous system of mice. Nat Biomed Eng. 2019 09; 3(9):706-716. Wen J, Wu D, Qin M, Liu C, Wang L, Xu D, Vinters HV, Liu Y, Kranz E, Guan X, Sun G, Sun X, Lee Y, Martinez-Maza O, Widney D, Lu Y, Chen ISY, Kamata M. PMID: 31384008; PMCID: PMC6736720.
      View in: PubMed   Mentions: 32     Fields:    Translation:Animals
    22. Efficient Delivery of Nerve Growth Factors to the Central Nervous System for Neural Regeneration. Adv Mater. 2019 Aug; 31(33):e1900727. Xu D, Wu D, Qin M, Nih LR, Liu C, Cao Z, Ren J, Chen X, He Z, Yu W, Guan J, Duan S, Liu F, Liu X, Li J, Harley D, Xu B, Hou L, Chen ISY, Wen J, Chen W, Pourtaheri S, Lu Y. PMID: 31125138.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    23. A Bioinspired Platform for Effective Delivery of Protein Therapeutics to the Central Nervous System. Adv Mater. 2019 May; 31(18):e1807557. Wu D, Qin M, Xu D, Wang L, Liu C, Ren J, Zhou G, Chen C, Yang F, Li Y, Zhao Y, Huang R, Pourtaheri S, Kang C, Kamata M, Chen ISY, He Z, Wen J, Chen W, Lu Y. PMID: 30803073; PMCID: PMC6701476.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    24. Systemic Delivery of Monoclonal Antibodies to the Central Nervous System for Brain Tumor Therapy. Adv Mater. 2019 May; 31(19):e1805697. Han L, Liu C, Qi H, Zhou J, Wen J, Wu D, Xu D, Qin M, Ren J, Wang Q, Long L, Liu Y, Chen I, Yuan X, Lu Y, Kang C. PMID: 30773720.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    25. Modeling Anti-HIV-1 HSPC-Based Gene Therapy in Humanized Mice Previously Infected with HIV-1. Mol Ther Methods Clin Dev. 2018 Jun 15; 9:23-32. Khamaikawin W, Shimizu S, Kamata M, Cortado R, Jung Y, Lam J, Wen J, Kim P, Xie Y, Kim S, Arokium H, Presson AP, Chen ISY, An DS. PMID: 29322065; PMCID: PMC5751878.
      View in: PubMed   Mentions: 11  
    26. Purging Exhausted Virus-Specific CD8 T Cell Phenotypes by Somatic Cell Reprogramming. AIDS Res Hum Retroviruses. 2017 Nov; 33(S1):S59-S69. Chan J, Kim PY, Kranz E, Nagaoka Y, Lee Y, Wen J, Elsaesser HJ, Qin M, Brooks DG, Ringpis GE, Chen ISY, Kamata M. PMID: 29140111; PMCID: PMC5684681.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    27. An intracellular protein delivery platform based on glutathione-responsive protein nanocapsules. Chem Commun (Camb). 2016 Nov 15; 52(93):13608-13611. Li J, Zhang L, Liu Y, Wen J, Wu D, Xu D, Segura T, Jin J, Lu Y, Wang H. PMID: 27808287.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    28. Growth-Factor Nanocapsules That Enable Tunable Controlled Release for Bone Regeneration. ACS Nano. 2016 08 23; 10(8):7362-9. Tian H, Du J, Wen J, Liu Y, Montgomery SR, Scott TP, Aghdasi B, Xiong C, Suzuki A, Hayashi T, Ruangchainikom M, Phan K, Weintraub G, Raed A, Murray SS, Daubs MD, Yang X, Yuan XB, Wang JC, Lu Y. PMID: 27227573.
      View in: PubMed   Mentions: 15     Fields:    
    29. Specific Elimination of Latently HIV-1 Infected Cells Using HIV-1 Protease-Sensitive Toxin Nanocapsules. PLoS One. 2016; 11(4):e0151572. Wen J, Yan M, Liu Y, Li J, Xie Y, Lu Y, Kamata M, Chen IS. PMID: 27049645; PMCID: PMC4822841.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    30. Modulation of Gene Expression by Polymer Nanocapsule Delivery of DNA Cassettes Encoding Small RNAs. PLoS One. 2015; 10(6):e0127986. Yan M, Wen J, Liang M, Lu Y, Kamata M, Chen IS. PMID: 26035832; PMCID: PMC4452785.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    31. Efficient delivery of therapeutic miRNA nanocapsules for tumor suppression. Adv Mater. 2015 Jan 14; 27(2):292-7. Liu C, Wen J, Meng Y, Zhang K, Zhu J, Ren Y, Qian X, Yuan X, Lu Y, Kang C. PMID: 25400269.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    32. Single siRNA nanocapsules for enhanced RNAi delivery. J Am Chem Soc. 2012 Aug 22; 134(33):13542-5. Yan M, Liang M, Wen J, Liu Y, Lu Y, Chen IS. PMID: 22866878; PMCID: PMC4318836.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    33. Controlled protein delivery based on enzyme-responsive nanocapsules. Adv Mater. 2011 Oct 18; 23(39):4549-53. Wen J, Anderson SM, Du J, Yan M, Wang J, Shen M, Lu Y, Segura T. PMID: 21910141; PMCID: PMC3263975.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    34. High-performance supercapacitors based on intertwined CNT/V2O5 nanowire nanocomposites. Adv Mater. 2011 Feb 08; 23(6):791-5. Chen Z, Augustyn V, Wen J, Zhang Y, Shen M, Dunn B, Lu Y. PMID: 21287644.
      View in: PubMed   Mentions: 33     Fields:    
    35. Single-crystal-like titania mesocages. Angew Chem Int Ed Engl. 2011 Feb 01; 50(5):1105-8. Bian Z, Zhu J, Wen J, Cao F, Huo Y, Qian X, Cao Y, Shen M, Li H, Lu Y. PMID: 21268205.
      View in: PubMed   Mentions: 3     Fields:    
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