Jose Alfonso Rodriguez

Title(s)Associate Professor, Chemistry and Biochemistry
SchoolCollege of Letters and Science
ORCID ORCID Icon0000-0002-0248-4964 Additional info
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    Collapse Biography 
    Collapse Education and Training
    UCLA, Los AngelesPhD2012Molecular Biology

    Collapse Overview 
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    Collapse Research 
    Collapse Research Activities and Funding
    Micro Electron Diffraction of Toxic and/or Infectious Macromolecular Nanoassemblies
    NIH R35GM128867Aug 1, 2018 - Jul 31, 2023
    Role: Principal Investigator
    Development of a broad spectrum therapeutic against New World hemorrhagic fevers
    NIH R21AI135851May 4, 2018 - Apr 30, 2021
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. AlphaFold-assisted structure determination of a bacterial protein of unknown function using X-ray and electron crystallography. Acta Crystallogr D Struct Biol. 2024 Apr 01. Miller JE, Agdanowski MP, Dolinsky JL, Sawaya MR, Cascio D, Rodriguez JA, Yeates TO. PMID: 38451205.
      View in: PubMed   Mentions:
    2. Crystallization-Induced Flower-like Superstructures via Peptoid Helix Assembly. ACS Macro Lett. 2024 Mar 26; 423-428. Yang KC, Rivera Mirabal DM, Garcia RV, Vlahakis NW, Nguyen PH, Mengel SD, Mecklenburg M, Rodriguez JA, Shell MS, Hawker CJ, Segalman RA. PMID: 38529829.
      View in: PubMed   Mentions:    Fields:    
    3. The structural line between prion and "prion-like": Insights from prion protein and tau. Curr Opin Neurobiol. 2024 Mar 14; 86:102857. Glynn C, Rodriguez JA, Hyman BT. PMID: 38489865.
      View in: PubMed   Mentions:    Fields:    
    4. Cryo-EM structure of a human LECT2 amyloid fibril reveals a network of polar ladders at its core. Structure. 2023 11 02; 31(11):1386-1393.e3. Richards LS, Flores MD, Zink S, Schibrowsky NA, Sawaya MR, Rodriguez JA. PMID: 37657439.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    5. Beyond MicroED: Ab Initio Structure Elucidation using 4D-STEM. Microsc Microanal. 2023 Jul 22; 29(Supplement_1):309-310. Saha A, Pattison A, Mecklenburg M, Brewster A, Ercius P, Rodriguez JA. PMID: 37613469.
      View in: PubMed   Mentions:    Fields:    
    6. Fragment-Based Ab Initio Phasing of Peptidic Nanocrystals by MicroED. ACS Bio Med Chem Au. 2023 Apr 19; 3(2):201-210. Richards LS, Flores MD, Millán C, Glynn C, Zee CT, Sawaya MR, Gallagher-Jones M, Borges RJ, Usón I, Rodriguez JA. PMID: 37096030; PMCID: PMC10119933.
      View in: PubMed   Mentions: 2  
    7. Cryo-EM Structure of a Human LECT2 Amyloid Fibril Reveals a Network of Polar Ladders at its Core. bioRxiv. 2023 Feb 11. Richards LS, Flores MD, Zink S, Schibrowsky NA, Sawaya MR, Rodriguez JA. PMID: 36798409; PMCID: PMC9934627.
      View in: PubMed   Mentions:
    8. Structural consequences of sequence variation in mammalian prion β2α2 loop segments. Front Neurosci. 2022; 16:960322. Glynn C, Hernandez E, Gallagher-Jones M, Miao J, Sigurdson CJ, Rodriguez JA. PMID: 36389229; PMCID: PMC9645039.
      View in: PubMed   Mentions:
    9. The expanding amyloid family: Structure, stability, function, and pathogenesis. Cell. 2021 09 16; 184(19):4857-4873. Sawaya MR, Hughes MP, Rodriguez JA, Riek R, Eisenberg DS. PMID: 34534463; PMCID: PMC8772536.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    10. Antibody-Based Inhibition of Pathogenic New World Hemorrhagic Fever Mammarenaviruses by Steric Occlusion of the Human Transferrin Receptor 1 Apical Domain. J Virol. 2021 08 10; 95(17):e0186820. Ferrero S, Flores MD, Short C, Vazquez CA, Clark LE, Ziegenbein J, Zink S, Fuentes D, Payes C, Batto MV, Collazo M, García CC, Abraham J, Cordo SM, Rodriguez JA, Helguera G. PMID: 34132574; PMCID: PMC8354235.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    11. Ab Initio Determination of Peptide Structures by MicroED. Methods Mol Biol. 2021; 2215:329-348. Zee CT, Saha A, Sawaya MR, Rodriguez JA. PMID: 33368013; PMCID: PMC8726681.
      View in: PubMed   Mentions: 3     Fields:    
    12. Structures from the Mesophase: MicroED Targets Crystals Extracted from LCP. Structure. 2020 10 06; 28(10):1084-1086. Gallagher-Jones M, Rodriguez JA. PMID: 33027690.
      View in: PubMed   Mentions:    Fields:    
    13. Fragment-based determination of a proteinase K structure from MicroED data using ARCIMBOLDO_SHREDDER. Acta Crystallogr D Struct Biol. 2020 Aug 01; 76(Pt 8):703-712. Richards LS, Millán C, Miao J, Martynowycz MW, Sawaya MR, Gonen T, Borges RJ, Usón I, Rodriguez JA. PMID: 32744252; PMCID: PMC7397493.
      View in: PubMed   Mentions: 6  Translation:Cells
    14. Advances in methods for atomic resolution macromolecular structure determination. F1000Res. 2020; 9. Thompson MC, Yeates TO, Rodriguez JA. PMID: 32676184; PMCID: PMC7333361.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    15. Cryo-EM structure of a human prion fibril with a hydrophobic, protease-resistant core. Nat Struct Mol Biol. 2020 05; 27(5):417-423. Glynn C, Sawaya MR, Ge P, Gallagher-Jones M, Short CW, Bowman R, Apostol M, Zhou ZH, Eisenberg DS, Rodriguez JA. PMID: 32284600; PMCID: PMC7338044.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimals
    16. Atomic structures determined from digitally defined nanocrystalline regions. IUCrJ. 2020 May 01; 7(Pt 3):490-499. Gallagher-Jones M, Bustillo KC, Ophus C, Richards LS, Ciston J, Lee S, Minor AM, Rodriguez JA. PMID: 32431832; PMCID: PMC7201287.
      View in: PubMed   Mentions: 1     Fields:    
    17. Structure-based inhibitors of amyloid beta core suggest a common interface with tau. Elife. 2019 10 15; 8. Griner SL, Seidler P, Bowler J, Murray KA, Yang TP, Sahay S, Sawaya MR, Cascio D, Rodriguez JA, Philipp S, Sosna J, Glabe CG, Gonen T, Eisenberg DS. PMID: 31612856; PMCID: PMC6850776.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    18. Data-driven challenges and opportunities in crystallography. Emerg Top Life Sci. 2019 Aug 16; 3(4):423-432. Glynn C, Rodriguez JA. PMID: 33523208; PMCID: PMC7289006.
      View in: PubMed   Mentions: 1     Fields:    
    19. Homochiral and racemic MicroED structures of a peptide repeat from the ice-nucleation protein InaZ. IUCrJ. 2019 Mar 01; 6(Pt 2):197-205. Zee CT, Glynn C, Gallagher-Jones M, Miao J, Santiago CG, Cascio D, Gonen T, Sawaya MR, Rodriguez JA. PMID: 30867917; PMCID: PMC6400192.
      View in: PubMed   Mentions: 9     Fields:    
    20. Nanoscale mosaicity revealed in peptide microcrystals by scanning electron nanodiffraction. Commun Biol. 2019; 2:26. Gallagher-Jones M, Ophus C, Bustillo KC, Boyer DR, Panova O, Glynn C, Zee CT, Ciston J, Mancia KC, Minor AM, Rodriguez JA. PMID: 30675524; PMCID: PMC6338664.
      View in: PubMed   Mentions: 14  
    21. The CryoEM Method MicroED as a Powerful Tool for Small Molecule Structure Determination. ACS Cent Sci. 2018 Nov 28; 4(11):1587-1592. Jones CG, Martynowycz MW, Hattne J, Fulton TJ, Stoltz BM, Rodriguez JA, Nelson HM, Gonen T. PMID: 30555912; PMCID: PMC6276044.
      View in: PubMed   Mentions: 124  
    22. Single-shot 3D coherent diffractive imaging of core-shell nanoparticles with elemental specificity. Sci Rep. 2018 05 29; 8(1):8284. Pryor A, Rana A, Xu R, Rodriguez JA, Yang Y, Gallagher-Jones M, Jiang H, Kanhaiya K, Nathanson M, Park J, Kim S, Kim S, Nam D, Yue Y, Fan J, Sun Z, Zhang B, Gardner DF, Dias CSB, Joti Y, Hatsui T, Kameshima T, Inubushi Y, Tono K, Lee JY, Yabashi M, Song C, Ishikawa T, Kapteyn HC, Murnane MM, Heinz H, Miao J. PMID: 29844398; PMCID: PMC5974371.
      View in: PubMed   Mentions: 3     Fields:    
    23. Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation. Nat Struct Mol Biol. 2018 06; 25(6):463-471. Guenther EL, Cao Q, Trinh H, Lu J, Sawaya MR, Cascio D, Boyer DR, Rodriguez JA, Hughes MP, Eisenberg DS. PMID: 29786080; PMCID: PMC5990464.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansCells
    24. Analysis of Global and Site-Specific Radiation Damage in Cryo-EM. Structure. 2018 05 01; 26(5):759-766.e4. Hattne J, Shi D, Glynn C, Zee CT, Gallagher-Jones M, Martynowycz MW, Rodriguez JA, Gonen T. PMID: 29706530; PMCID: PMC6333475.
      View in: PubMed   Mentions: 84     Fields:    
    25. Atomic structures of low-complexity protein segments reveal kinked β sheets that assemble networks. Science. 2018 02 09; 359(6376):698-701. Hughes MP, Sawaya MR, Boyer DR, Goldschmidt L, Rodriguez JA, Cascio D, Chong L, Gonen T, Eisenberg DS. PMID: 29439243; PMCID: PMC6192703.
      View in: PubMed   Mentions: 195     Fields:    Translation:HumansCells
    26. Sub-ångström cryo-EM structure of a prion protofibril reveals a polar clasp. Nat Struct Mol Biol. 2018 02; 25(2):131-134. Gallagher-Jones M, Glynn C, Boyer DR, Martynowycz MW, Hernandez E, Miao J, Zee CT, Novikova IV, Goldschmidt L, McFarlane HT, Helguera GF, Evans JE, Sawaya MR, Cascio D, Eisenberg DS, Gonen T, Rodriguez JA. PMID: 29335561; PMCID: PMC6170007.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    27. Common fibrillar spines of amyloid-β and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors. J Biol Chem. 2018 02 23; 293(8):2888-2902. Krotee P, Griner SL, Sawaya MR, Cascio D, Rodriguez JA, Shi D, Philipp S, Murray K, Saelices L, Lee J, Seidler P, Glabe CG, Jiang L, Gonen T, Eisenberg DS. PMID: 29282295; PMCID: PMC5827424.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    28. Microbial Community and Biochemical Dynamics of Biological Soil Crusts across a Gradient of Surface Coverage in the Central Mojave Desert. Front Microbiol. 2017; 8:1974. Mogul R, Vaishampayan P, Bashir M, McKay CP, Schubert K, Bornaccorsi R, Gomez E, Tharayil S, Payton G, Capra J, Andaya J, Bacon L, Bargoma E, Black D, Boos K, Brant M, Chabot M, Chau D, Cisneros J, Chu G, Curnutt J, DiMizio J, Engelbrecht C, Gott C, Harnoto R, Hovanesian R, Johnson S, Lavergne B, Martinez G, Mans P, Morales E, Oei A, Peplow G, Piaget R, Ponce N, Renteria E, Rodriguez V, Rodriguez J, Santander M, Sarmiento K, Scheppelmann A, Schroter G, Sexton D, Stephenson J, Symer K, Russo-Tait T, Weigel B, Wilhelm MB. PMID: 29109701; PMCID: PMC5660283.
      View in: PubMed   Mentions: 12  
    29. GENFIRE: A generalized Fourier iterative reconstruction algorithm for high-resolution 3D imaging. Sci Rep. 2017 09 05; 7(1):10409. Pryor A, Yang Y, Rana A, Gallagher-Jones M, Zhou J, Lo YH, Melinte G, Chiu W, Rodriguez JA, Miao J. PMID: 28874736; PMCID: PMC5585178.
      View in: PubMed   Mentions: 24     Fields:    
    30. Toward the Atomic Structure of PrPSc. Cold Spring Harb Perspect Biol. 2017 Sep 01; 9(9). Rodriguez JA, Jiang L, Eisenberg DS. PMID: 28096267; PMCID: PMC5585850.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    31. Taking the measure of MicroED. Curr Opin Struct Biol. 2017 10; 46:79-86. Rodriguez JA, Eisenberg DS, Gonen T. PMID: 28648726; PMCID: PMC5683914.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    32. Atomic structures of fibrillar segments of hIAPP suggest tightly mated β-sheets are important for cytotoxicity. Elife. 2017 01 03; 6. Krotee P, Rodriguez JA, Sawaya MR, Cascio D, Reyes FE, Shi D, Hattne J, Nannenga BL, Oskarsson ME, Philipp S, Griner S, Jiang L, Glabe CG, Westermark GT, Gonen T, Eisenberg DS. PMID: 28045370; PMCID: PMC5207774.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    33. De novo phasing with X-ray laser reveals mosquito larvicide BinAB structure. Nature. 2016 11 03; 539(7627):43-47. Colletier JP, Sawaya MR, Gingery M, Rodriguez JA, Cascio D, Brewster AS, Michels-Clark T, Hice RH, Coquelle N, Boutet S, Williams GJ, Messerschmidt M, DePonte DP, Sierra RG, Laksmono H, Koglin JE, Hunter MS, Park HW, Uervirojnangkoorn M, Bideshi DK, Brunger AT, Federici BA, Sauter NK, Eisenberg DS. PMID: 27680699; PMCID: PMC5161637.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    34. Structure of the toxic core of α-synuclein from invisible crystals. Nature. 2015 Sep 24; 525(7570):486-90. Rodriguez JA, Ivanova MI, Sawaya MR, Cascio D, Reyes FE, Shi D, Sangwan S, Guenther EL, Johnson LM, Zhang M, Jiang L, Arbing MA, Nannenga BL, Hattne J, Whitelegge J, Brewster AS, Messerschmidt M, Boutet S, Sauter NK, Gonen T, Eisenberg DS. PMID: 26352473; PMCID: PMC4791177.
      View in: PubMed   Mentions: 271     Fields:    Translation:HumansCells
    35. Three-dimensional coherent X-ray diffractive imaging of whole frozen-hydrated cells. IUCrJ. 2015 Sep 01; 2(Pt 5):575-83. Rodriguez JA, Xu R, Chen CC, Huang Z, Jiang H, Chen AL, Raines KS, Pryor A, Nam D, Wiegart L, Song C, Madsen A, Chushkin Y, Zontone F, Bradley PJ, Miao J. PMID: 26306199; PMCID: PMC4547825.
      View in: PubMed   Mentions: 22     Fields:    
    36. Accessible atomic structures from sub-micron protein crystals. Acta Crystallogr A Found Adv. 2015 Jul; 71(Pt 4):351-2. Rodriguez JA. PMID: 26131893.
      View in: PubMed   Mentions:    Fields:    
    37. Single-shot three-dimensional structure determination of nanocrystals with femtosecond X-ray free-electron laser pulses. Nat Commun. 2014 Jun 05; 5:4061. Xu R, Jiang H, Song C, Rodriguez JA, Huang Z, Chen CC, Nam D, Park J, Gallagher-Jones M, Kim S, Kim S, Suzuki A, Takayama Y, Oroguchi T, Takahashi Y, Fan J, Zou Y, Hatsui T, Inubushi Y, Kameshima T, Yonekura K, Tono K, Togashi T, Sato T, Yamamoto M, Nakasako M, Yabashi M, Ishikawa T, Miao J. PMID: 24898682.
      View in: PubMed   Mentions: 31     Fields:    
    38. Phasing tiny crystals. IUCrJ. 2014 Jan 01; 1(Pt 1):3-4. Miao J, Rodriguez JA. PMID: 25075313; PMCID: PMC4104970.
      View in: PubMed   Mentions: 1     Fields:    
    39. Oversampling smoothness: an effective algorithm for phase retrieval of noisy diffraction intensities. J Appl Crystallogr. 2013 Apr 01; 46(Pt 2):312-318. Rodriguez JA, Xu R, Chen CC, Zou Y, Miao J. PMID: 23596339; PMCID: PMC3627409.
      View in: PubMed   Mentions: 21  
    40. The transferrin receptor part I: Biology and targeting with cytotoxic antibodies for the treatment of cancer. Clin Immunol. 2006 Nov; 121(2):144-58. Daniels TR, Delgado T, Rodriguez JA, Helguera G, Penichet ML. PMID: 16904380.
      View in: PubMed   Mentions: 232     Fields:    Translation:HumansAnimalsCells
    41. Molecular events contributing to cell death in malignant human hematopoietic cells elicited by an IgG3-avidin fusion protein targeting the transferrin receptor. Blood. 2006 Oct 15; 108(8):2745-54. Ng PP, Helguera G, Daniels TR, Lomas SZ, Rodriguez JA, Schiller G, Bonavida B, Morrison SL, Penichet ML. PMID: 16804109; PMCID: PMC1895578.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
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