Irene Chen

Photo of Irene Chen
Title(s)Professor, Chemical And Biomolecular Engineering
SchoolHenry Samueli School of Engineering and Applied Science
ORCID ORCID Icon0000-0001-6040-7927 Additional info
vCardDownload vCard
    Other Positions
    Title(s)Professor, Chemistry and Biochemistry


    Collapse Overview 
    Collapse overview
    Irene A. Chen is a Professor in the Department of Chemical and Biomolecular Engineering at the University of California, Los Angeles. Her laboratory studies life-like biochemical systems to understand their fundamental properties and address emerging challenges in biotechnology and infectious disease.

    Collapse Biography 
    Collapse education and training
    Harvard University, Cambridge, MAAB1999Chemistry
    Harvard Medical School, Boston, MAMD2007Medicine, Health Sciences and Technology
    Harvard University, Cambridge, MAPhD2007Biophysics
    Harvard University, Cambridge, MAFellow2013Systems Biology
    Collapse awards and honors
    2018  - 2023Camille Dreyfus Teacher-Scholar Award
    2013  - 2023Simons Investigator, Collaboration on the Origins of Life
    2016  - 2021NIH New Innovator Award
    2014  - 2017Searle Scholar Award

    Collapse Research 
    Collapse research activities and funding
    Development of a safer, more effective formulation of Polymyxin B for treatment of E. coli Infection
    NIH R43AI191983Aug 10, 2026 - Jul 30, 2028
    Role: Co-Principal Investigator
    Phage-inspired engineering and evolution
    NIH R35GM148249Sep 15, 2023 - Aug 31, 2028
    Role: Principal Investigator
    Understanding how bacteriophages affect wound ecologies and developing new tools to harness bacteria-phage interactions
    NIH DP2GM123457Sep 30, 2016 - May 31, 2021
    Role: Principal Investigator

    Collapse Featured Content 

    Collapse Bibliographic 
    Collapse publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Circulating cholesterol fuels SARS-CoV-2 replication via ORF3a. EMBO Rep. 2026 Sep 11. Hayashi JM, Taha TY, Chen IP, Suryawanshi RK, Swaney DL, McCavitt-Malvido M, Montano M, Syed AM, Khalid MM, Simoneau CR, Chen PY, Leon KE, Tsou CL, Stevenson E, Gordon M, Chaplin NR, Jorgens DM, Wang Z, Puschnik AS, Doudna JA, Krogan NJ, Ott M. PMID: 42728375.
      View in: PubMed   Mentions:
    2. Halictine-II as a Potential Broad-Spectrum Antifungal and Antibacterial Agent. Pharmaceuticals (Basel). 2026 Sep 01; 19(9). Zhang N, Kutach M, Hsieh L, Vexler S, Chen IA. PMID: 42797425.
      View in: PubMed   Mentions:
    3. Coronavirus protein interaction mapping in bat and human cells reveals network rewiring governing immune evasion and zoonotic potential. Cell Host Microbe. 2026 Jun 10; 34(6):1100-1117.e13. Batra J, Rutkowska M, Zhou Y, Ye C, Adavikolanu R, Young JM, Anand D, Verma S, Parthasarathy H, Gordon M, Malpotra S, Cupic A, Kehrer T, Dos Santos M, Benjamin R, Moen JM, Winters DM, Caval V, Rojc A, Mena I, Aslam S, Martinez-Romero C, Viñas IC, Khalil Z, Farrugia K, Villalón-Letelier F, Banerjee A, Tussia-Cohen D, Diallo A, Maji S, Muralidharan M, Foussard H, Chen IP, Fuchs R, San Felipe CJ, Zuliani-Alvarez L, Choudhury P, Obernier K, Gracias S, Suryawanshi RK, Bonaventure B, Ibáñez C, Johnson JR, Juste J, Pache L, Stroud RM, Verba KA, Fraser JS, van Bakel H, Taha TY, Ott M, Hagai T, Jouvenet N, Demeret C, Polacco BJ, Swaney DL, Echeverria I, Bouhaddou M, Eckhardt M, Malik HS, Martinez-Sobrido L, Miorin L, García-Sastre A, Krogan NJ. PMID: 42134328; PMCID: PMC13286030.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Regulation of virion production by the ORF8 signal peptide across SARS-CoV-2 variants. bioRxiv. 2026 Feb 03. Khalid MM, Chen IP, Soveg FS, Taha TY, Tabata T, Suryawanshi RK, Syed AM, Ciling A, McCavitt-Malvido M, Schulze-Gahmen U, Hayashi J, Kim IJ, Fong SW, Batra J, Kumar GR, Renia L, Ng LF, Krogan NJ, Doudna JA, Verdin E, Ott M. PMID: 41676649; PMCID: PMC12889891.
      View in: PubMed   Mentions:
    5. Silver Nanoparticles Templated by the M13 Phage Exhibit High Antibacterial Activity against Gram-Negative Pathogens and a Reduced Rate of Bacterial Resistance In Vitro. Langmuir. 2025 12 09; 41(48):32270-32284. Bagchi D, Adhikari A, McCarthy K, Kang D, Chen Y, Chen IA. PMID: 41307449; PMCID: PMC12874522.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    6. Metagenome-inspired libraries to engineer phage M13 for targeted killing of Gram-negative bacterial species. Nucleic Acids Res. 2025 Sep 23; 53(18). Yang Y, Kang D, Mihalache B, Vexler S, Jain S, Peng H, Annabi N, Yang S, Chen IA. PMID: 41020500; PMCID: PMC12477597.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    7. A Synthetic Phage-Peptide Conjugate as a Potent Antibacterial Agent for Pseudomonas aeruginosa Infections. ACS Cent Sci. 2025 Sep 24; 11(9):1715-1735. Yang Y, Vexler S, Jordan MC, Abbondante S, Kang D, Peng H, Marshall M, Naini BV, Jain S, Lai YC, Annabi N, Roos KP, Pearlman E, Chen IA. PMID: 41019108; PMCID: PMC12464783.
      View in: PubMed   Mentions:
    8. Biosourced Functional Hydroxybenzoate-co-Lactide Polymers with Antimicrobial Activity. J Am Chem Soc. 2025 06 04; 147(22):19230-19238. Salas-Ambrosio P, Vexler S, P Sivasankaran R, Vlahakis N, Lai RS, Johnson C, Baas-Maynard SI, Min DS, Lower H, Doyle AG, Tang Y, Rodriguez JA, Chen IA, Read de Alaniz J, Maynard HD. PMID: 40380948; PMCID: PMC12147117.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    9. Real-Time in Vivo Bacterial Imaging by Computed Tomography and Fluorescence Using Phage-Gold Nanorod Bioconjugates as Contrast Agents. ACS Biomater Sci Eng. 2025 Jun 09; 11(6):3297-3306. Peng H, Vexler S, Xu S, Chen IA. PMID: 40340326; PMCID: PMC12152831.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    10. EasyDIVER + : An Advanced Tool for Analyzing High Throughput Sequencing Data from In Vitro Evolution of Nucleic Acids or Amino Acids. J Mol Evol. 2025 04; 93(2):229-237. Blanco C, Tee A, Sharma P, Newton MS, Lee KH, Erickson SE, Seelig B, Chen IA. PMID: 40186644; PMCID: PMC12006205.
      View in: PubMed   Mentions:
    11. Enhanced RNA replication and pathogenesis in recent SARS-CoV-2 variants harboring the L260F mutation in NSP6. PLoS Pathog. 2025 03; 21(3):e1013020. Taha TY, Ezzatpour S, Hayashi JM, Ye C, Zapatero-Belinchón FJ, Rosecrans JA, Kimmerly GR, Chen IP, Walcott K, Kurianowicz A, Jorgens DM, Chaplin NR, Choi A, Buchholz DW, Sahler J, Hilt ZT, Imbiakha B, Vagi-Szmola C, Montano M, Stevenson E, Gordon M, Swaney DL, Krogan NJ, Whittaker GR, Martinez-Sobrido L, Aguilar HC, Ott M. PMID: 40163530; PMCID: PMC11981139.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    12. Antibody-Nanoparticle Conjugates in Therapy: Combining the Best of Two Worlds. Small. 2025 04; 21(15):e2409635. Adhikari A, Chen IA. PMID: 40051146; PMCID: PMC12001320.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    13. Sparse Bayesian Group Factor Model for Feature Interactions in Multiple Count Tables Data. J Am Stat Assoc. 2025; 120(550):723-726. Zhang S, Shen Y, Chen IA, Lee J. PMID: 40678201; PMCID: PMC12266606.
      View in: PubMed   Mentions:
    14. Intellectual frameworks to understand complex biochemical systems at the origin of life. Nat Chem. 2025 01; 17(1):11-19. Seelig B, Chen IA. PMID: 39762573.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    15. Engineering Phages to Fight Multidrug-Resistant Bacteria. Chem Rev. 2025 01 22; 125(2):933-971. Peng H, Chen IA, Qimron U. PMID: 39680919; PMCID: PMC11758799.
      View in: PubMed   Mentions:
    16. Confronting risks of mirror life. Science. 2024 12 20; 386(6728):1351-1353. Adamala KP, Agashe D, Belkaid Y, Bittencourt DMC, Cai Y, Chang MW, Chen IA, Church GM, Cooper VS, Davis MM, Devaraj NK, Endy D, Esvelt KM, Glass JI, Hand TW, Inglesby TV, Isaacs FJ, James WG, Jones JDG, Kay MS, Lenski RE, Liu C, Medzhitov R, Nicotra ML, Oehm SB, Pannu J, Relman DA, Schwille P, Smith JA, Suga H, Szostak JW, Talbot NJ, Tiedje JM, Venter JC, Winter G, Zhang W, Zhu X, Zuber MT. PMID: 39666824.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    17. SARS-CoV-2 evolution balances conflicting roles of N protein phosphorylation. PLoS Pathog. 2024 11; 20(11):e1012741. Syed AM, Ciling A, Chen IP, Carlson CR, Adly AN, Martin HS, Taha TY, Khalid MM, Price N, Bouhaddou M, Ummadi MR, Moen JM, Krogan NJ, Morgan DO, Ott M, Doudna JA. PMID: 39571001; PMCID: PMC11620656.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    18. Protocells by spontaneous reaction of cysteine with short-chain thioesters. Nat Chem. 2025 01; 17(1):148-155. Cho CJ, An T, Lai YC, Vázquez-Salazar A, Fracassi A, Brea RJ, Chen IA, Devaraj NK. PMID: 39478161; PMCID: PMC12161135.
      View in: PubMed   Mentions: 8     Fields:    
    19. Prebiotic chiral transfer from self-aminoacylating ribozymes may favor either handedness. Nat Commun. 2024 09 12; 15(1):7980. Kenchel J, Vázquez-Salazar A, Wells R, Brunton K, Janzen E, Schultz KM, Liu Z, Li W, Parker ET, Dworkin JP, Chen IA. PMID: 39266567; PMCID: PMC11393417.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    20. De novo-designed minibinders expand the synthetic biology sensing repertoire. bioRxiv. 2024 Aug 29. Weinberg ZY, Soliman SS, Kim MS, Shah DH, Chen IP, Ott M, Lim WA, El-Samad H. PMID: 38293112; PMCID: PMC10827046.
      View in: PubMed   Mentions:
    21. Protocell Effects on RNA Folding, Function, and Evolution. Acc Chem Res. 2024 08 06; 57(15):2058-2066. Saha R, Choi JA, Chen IA. PMID: 39005057; PMCID: PMC11308369.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    22. NF-κB inhibitor alpha controls SARS-CoV-2 infection in ACE2-overexpressing human airway organoids. Sci Rep. 2024 07 04; 14(1):15351. Simoneau CR, Chen PY, Xing GK, Hayashi JM, Chen IP, Khalid MM, Meyers NL, Taha TY, Leon KE, Suryawanshi RK, McCavitt-Malvido M, Ashuach T, Fontaine KA, Rodriguez L, Joehnk B, Walcott K, Vasudevan S, Fang X, Maishan M, Schultz S, Roose JP, Matthay MA, Sil A, Arjomandi M, Yosef N, Ott M. PMID: 38961189; PMCID: PMC11222426.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    23. Fitness Landscapes and Evolution of Catalytic RNA. Annu Rev Biophys. 2024 07; 53(1):109-125. Saha R, Vázquez-Salazar A, Nandy A, Chen IA. PMID: 39013026.
      View in: PubMed   Mentions: 3     Fields:    
    24. RNA life on the edge of catastrophe. Proc Natl Acad Sci U S A. 2024 Mar 26; 121(13):e2402649121. Chen IA. PMID: 38478681; PMCID: PMC10990123.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    25. Visualization of Engineered M13 Phages Bound to Bacterial Targets by Transmission Electron Microscopy. Methods Mol Biol. 2024; 2793:175-183. Yang Y, Chen IA. PMID: 38526731; PMCID: PMC11296667.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    26. Preparation of Bioconjugates of Chimeric M13 Phage and Gold Nanorods. Methods Mol Biol. 2024; 2793:131-141. Peng H, Chen IA. PMID: 38526728; PMCID: PMC11371271.
      View in: PubMed   Mentions:
    27. Pharmacokinetics and Biodistribution of Phages and their Current Applications in Antimicrobial Therapy. Adv Ther (Weinh). 2024 Mar; 7(3). Kang D, Bagchi D, Chen IA. PMID: 38933919; PMCID: PMC11198966.
      View in: PubMed   Mentions: 11  
    28. Effect of montmorillonite K10 clay on RNA structure and function. Biophys J. 2024 02 20; 123(4):451-463. Saha R, Kao WL, Malady B, Heng X, Chen IA. PMID: 37924206; PMCID: PMC10912936.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    29. Previous exposure to Spike-providing parental strains confers neutralizing immunity to XBB lineage and other SARS-CoV-2 recombinants in the context of vaccination. Emerg Microbes Infect. 2023 Dec; 12(2):2270071. Suryawanshi RK, Taha TY, McCavitt-Malvido M, Silva I, Khalid MM, Syed AM, Chen IP, Saldhi P, Sreekumar B, Montano M, Foresythe K, Tabata T, Kumar GR, Sotomayor-Gonzalez A, Servellita V, Gliwa A, Nguyen J, Kojima N, Arellanor T, Bussanich A, Hess V, Shacreaw M, Lopez L, Brobeck M, Turner F, Wang Y, Ghazarian S, Davis G, Rodriguez D, Doudna J, Spraggon L, Chiu CY, Ott M. PMID: 37869789; PMCID: PMC10619466.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCellsPHPublic Health
    30. Post-acute immunological and behavioral sequelae in mice after Omicron infection. bioRxiv. 2023 Oct 04. Ma T, Suryawanshi RK, Miller SR, Ly KK, Thomas R, Elphick N, Yin K, Luo X, Kaliss N, Chen IP, Montano M, Sreekumar B, Standker L, Münch J, Heath Damron F, Palop JJ, Ott M, Roan NR. PMID: 37333294; PMCID: PMC10274741.
      View in: PubMed   Mentions:
    31. A single inactivating amino acid change in the SARS-CoV-2 NSP3 Mac1 domain attenuates viral replication in vivo. PLoS Pathog. 2023 08; 19(8):e1011614. Taha TY, Suryawanshi RK, Chen IP, Correy GJ, McCavitt-Malvido M, O'Leary PC, Jogalekar MP, Diolaiti ME, Kimmerly GR, Tsou CL, Gascon R, Montano M, Martinez-Sobrido L, Krogan NJ, Ashworth A, Fraser JS, Ott M. PMID: 37651466; PMCID: PMC10499221.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    32. Discovering pathways through ribozyme fitness landscapes using information theoretic quantification of epistasis. RNA. 2023 11; 29(11):1644-1657. Charest N, Shen Y, Lai YC, Chen IA, Shea JE. PMID: 37580126; PMCID: PMC10578471.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    33. Rapid assembly of SARS-CoV-2 genomes reveals attenuation of the Omicron BA.1 variant through NSP6. Nat Commun. 2023 04 21; 14(1):2308. Taha TY, Chen IP, Hayashi JM, Tabata T, Walcott K, Kimmerly GR, Syed AM, Ciling A, Suryawanshi RK, Martin HS, Bach BH, Tsou CL, Montano M, Khalid MM, Sreekumar BK, Renuka Kumar G, Wyman S, Doudna JA, Ott M. PMID: 37085489; PMCID: PMC10120482.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    34. Caffeine and Cationic Copolymers with Antimicrobial Properties. ACS Bio Med Chem Au. 2023 Apr 19; 3(2):189-200. Salas-Ambrosio P, Vexler S, P S R, Chen IA, Maynard HD. PMID: 37096032; PMCID: PMC10119941.
      View in: PubMed   Mentions: 7  
    35. Effects of Preservation and Propagation Methodology on Microcosms Derived from the Oral Microbiome. Microorganisms. 2022 Oct 29; 10(11). Zhou B, Mobberley J, Shi K, Chen IA. PMID: 36363738; PMCID: PMC9693135.
      View in: PubMed   Mentions: 3  
    36. SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein. PLoS Pathog. 2022 09; 18(9):e1010811. Walter M, Chen IP, Vallejo-Gracia A, Kim IJ, Bielska O, Lam VL, Hayashi JM, Cruz A, Shah S, Soveg FW, Gross JD, Krogan NJ, Jerome KR, Schilling B, Ott M, Verdin E. PMID: 36095012; PMCID: PMC9499238.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    37. Modulation of α-Synuclein Aggregation In Vitro by a DNA Aptamer. Biochemistry. 2022 09 06; 61(17):1757-1765. Tran CH, Saha R, Blanco C, Bagchi D, Chen IA. PMID: 35994742; PMCID: PMC9454088.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    38. Omicron mutations enhance infectivity and reduce antibody neutralization of SARS-CoV-2 virus-like particles. Proc Natl Acad Sci U S A. 2022 08 02; 119(31):e2200592119. Syed AM, Ciling A, Taha TY, Chen IP, Khalid MM, Sreekumar B, Chen PY, Kumar GR, Suryawanshi R, Silva I, Milbes B, Kojima N, Hess V, Shacreaw M, Lopez L, Brobeck M, Turner F, Spraggon L, Tabata T, Ott M, Doudna JA. PMID: 35858386; PMCID: PMC9351483.
      View in: PubMed   Mentions: 131     Fields:    Translation:HumansCells
    39. Viral E protein neutralizes BET protein-mediated post-entry antagonism of SARS-CoV-2. Cell Rep. 2022 07 19; 40(3):111088. Chen IP, Longbotham JE, McMahon S, Suryawanshi RK, Khalid MM, Taha TY, Tabata T, Hayashi JM, Soveg FW, Carlson-Stevermer J, Gupta M, Zhang MY, Lam VL, Li Y, Yu Z, Titus EW, Diallo A, Oki J, Holden K, Krogan N, Fujimori DG, Ott M. PMID: 35839775; PMCID: PMC9234021.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    40. Emergent properties as by-products of prebiotic evolution of aminoacylation ribozymes. Nat Commun. 2022 06 25; 13(1):3631. Janzen E, Shen Y, Vázquez-Salazar A, Liu Z, Blanco C, Kenchel J, Chen IA. PMID: 35752631; PMCID: PMC9233669.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    41. In vitro evolution: From monsters to mobs. Curr Biol. 2022 06 20; 32(12):R580-R583. Vázquez-Salazar A, Chen IA. PMID: 35728532.
      View in: PubMed   Mentions:    Fields:    
    42. Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination. Nature. 2022 07; 607(7918):351-355. Suryawanshi RK, Chen IP, Ma T, Syed AM, Brazer N, Saldhi P, Simoneau CR, Ciling A, Khalid MM, Sreekumar B, Chen PY, Kumar GR, Montano M, Gascon R, Tsou CL, Garcia-Knight MA, Sotomayor-Gonzalez A, Servellita V, Gliwa A, Nguyen J, Silva I, Milbes B, Kojima N, Hess V, Shacreaw M, Lopez L, Brobeck M, Turner F, Soveg FW, George AF, Fang X, Maishan M, Matthay M, Morris MK, Wadford D, Hanson C, Greene WC, Andino R, Spraggon L, Roan NR, Chiu CY, Doudna JA, Ott M. PMID: 35584773; PMCID: PMC9279157.
      View in: PubMed   Mentions: 140     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    43. The Chronic Wound Phageome: Phage Diversity and Associations with Wounds and Healing Outcomes. Microbiol Spectr. 2022 06 29; 10(3):e0277721. Verbanic S, Deacon JM, Chen IA. PMID: 35435739; PMCID: PMC9248897.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    44. Treatment of Wound Infections in a Mouse Model Using Zn2+-Releasing Phage Bound to Gold Nanorods. ACS Nano. 2022 03 22; 16(3):4756-4774. Peng H, Rossetto D, Mansy SS, Jordan MC, Roos KP, Chen IA. PMID: 35239330; PMCID: PMC8981316.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    45. Omicron mutations enhance infectivity and reduce antibody neutralization of SARS-CoV-2 virus-like particles. medRxiv. 2022 Jan 02. Syed AM, Ciling A, Khalid MM, Sreekumar B, Chen PY, Kumar GR, Silva I, Milbes B, Kojima N, Hess V, Shacreaw M, Lopez L, Brobeck M, Turner F, Spraggon L, Taha TY, Tabata T, Chen IP, Ott M, Doudna JA. PMID: 34981067; PMCID: PMC8722610.
      View in: PubMed   Mentions:
    46. Vesicle encapsulation stabilizes intermolecular association and structure formation of functional RNA and DNA. Curr Biol. 2022 01 10; 32(1):86-96.e6. Peng H, Lelievre A, Landenfeld K, Müller S, Chen IA. PMID: 34762821; PMCID: PMC8752491.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    47. Rapid assessment of SARS-CoV-2-evolved variants using virus-like particles. Science. 2021 Dec 24; 374(6575):1626-1632. Syed AM, Taha TY, Tabata T, Chen IP, Ciling A, Khalid MM, Sreekumar B, Chen PY, Hayashi JM, Soczek KM, Ott M, Doudna JA. PMID: 34735219; PMCID: PMC9005165.
      View in: PubMed   Mentions: 212     Fields:    Translation:HumansAnimalsCells
    48. PacBio sequencing output increased through uniform and directional fivefold concatenation. Sci Rep. 2021 09 10; 11(1):18065. Kanwar N, Blanco C, Chen IA, Seelig B. PMID: 34508117; PMCID: PMC8433307.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    49. Kinetic sequencing (k-Seq) as a massively parallel assay for ribozyme kinetics: utility and critical parameters. Nucleic Acids Res. 2021 07 09; 49(12):e67. Shen Y, Pressman A, Janzen E, Chen IA. PMID: 33772580; PMCID: PMC8559535.
      View in: PubMed   Mentions: 14     Fields:    
    50. Self-cleaving ribozymes: substrate specificity and synthetic biology applications. RSC Chem Biol. 2021 Oct 07; 2(5):1370-1383. Peng H, Latifi B, Müller S, Lupták A, Chen IA. PMID: 34704043; PMCID: PMC8495972.
      View in: PubMed   Mentions: 27  
    51. Encapsulation of ribozymes inside model protocells leads to faster evolutionary adaptation. Proc Natl Acad Sci U S A. 2021 05 25; 118(21). Lai YC, Liu Z, Chen IA. PMID: 34001592; PMCID: PMC8166191.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    52. Phage engineering and the evolutionary arms race. Curr Opin Biotechnol. 2021 04; 68:23-29. Peng H, Chen IA. PMID: 33113495; PMCID: PMC8062571.
      View in: PubMed   Mentions: 28     Fields:    Translation:Cells
    53. EasyDIVER: A Pipeline for Assembling and Counting High-Throughput Sequencing Data from In Vitro Evolution of Nucleic Acids or Peptides. J Mol Evol. 2020 08; 88(6):477-481. Blanco C, Verbanic S, Seelig B, Chen IA. PMID: 32529275; PMCID: PMC7324411.
      View in: PubMed   Mentions: 11     Fields:    
    54. Protocells. Curr Biol. 2020 05 18; 30(10):R482-R485. Lai YC, Chen IA. PMID: 32428486.
      View in: PubMed   Mentions: 9     Fields:    
    55. Chimeric Phage Nanoparticles for Rapid Characterization of Bacterial Pathogens: Detection in Complex Biological Samples and Determination of Antibiotic Sensitivity. ACS Sens. 2020 05 22; 5(5):1491-1499. Peng H, Borg RE, Nguyen ABN, Chen IA. PMID: 32314570; PMCID: PMC7266372.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    56. Microbial predictors of healing and short-term effect of debridement on the microbiome of chronic wounds. NPJ Biofilms Microbiomes. 2020 05 01; 6(1):21. Verbanic S, Shen Y, Lee J, Deacon JM, Chen IA. PMID: 32358500; PMCID: PMC7195478.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansCells
    57. Promiscuous Ribozymes and Their Proposed Role in Prebiotic Evolution. Chem Rev. 2020 06 10; 120(11):4879-4897. Janzen E, Blanco C, Peng H, Kenchel J, Chen IA. PMID: 32011135; PMCID: PMC7291351.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    58. High throughput sequencing of in vitro selections of mRNA-displayed peptides: data analysis and applications. Phys Chem Chem Phys. 2020 Mar 28; 22(12):6492-6506. Blanco C, Verbanic S, Seelig B, Chen IA. PMID: 31967131; PMCID: PMC8219182.
      View in: PubMed   Mentions: 7     Fields:    
    59. Controlled phage therapy by photothermal ablation of specific bacterial species using gold nanorods targeted by chimeric phages. Proc Natl Acad Sci U S A. 2020 01 28; 117(4):1951-1961. Peng H, Borg RE, Dow LP, Pruitt BL, Chen IA. PMID: 31932441; PMCID: PMC6994977.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    60. Improved single-swab sample preparation for recovering bacterial and phage DNA from human skin and wound microbiomes. BMC Microbiol. 2019 09 05; 19(1):214. Verbanic S, Kim CY, Deacon JM, Chen IA. PMID: 31488062; PMCID: PMC6729076.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    61. From soup to peptides. Nat Chem. 2019 09; 11(9):763-764. Pascal R, Chen IA. PMID: 31406322.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    62. Effect of UV Radiation on Fluorescent RNA Aptamers' Functional and Templating Ability. Chembiochem. 2019 10 15; 20(20):2609-2617. Saha R, Chen IA. PMID: 31125512; PMCID: PMC6899979.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    63. Therapeutic Ligands Antagonize Estrogen Receptor Function by Impairing Its Mobility. Cell. 2019 08 08; 178(4):949-963.e18. Guan J, Zhou W, Hafner M, Blake RA, Chalouni C, Chen IP, De Bruyn T, Giltnane JM, Hartman SJ, Heidersbach A, Houtman R, Ingalla E, Kategaya L, Kleinheinz T, Li J, Martin SE, Modrusan Z, Nannini M, Oeh J, Ubhayakar S, Wang X, Wertz IE, Young A, Yu M, Sampath D, Hager JH, Friedman LS, Daemen A, Metcalfe C. PMID: 31353221.
      View in: PubMed   Mentions: 102     Fields:    Translation:HumansAnimalsCells
    64. Phage therapy administered noninvasively could be effective in thin tubes subject to episodic flow despite washout: a simulation study. Phys Biol. 2019 07 22; 16(5):054001. Blanco C, Chen IA. PMID: 31266001; PMCID: PMC6771420.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    65. Mapping a Systematic Ribozyme Fitness Landscape Reveals a Frustrated Evolutionary Network for Self-Aminoacylating RNA. J Am Chem Soc. 2019 04 17; 141(15):6213-6223. Pressman AD, Liu Z, Janzen E, Blanco C, Müller UF, Joyce GF, Pascal R, Chen IA. PMID: 30912655; PMCID: PMC6548421.
      View in: PubMed   Mentions: 58     Fields:    Translation:Cells
    66. Molecular Fitness Landscapes from High-Coverage Sequence Profiling. Annu Rev Biophys. 2019 05 06; 48:1-18. Blanco C, Janzen E, Pressman A, Saha R, Chen IA. PMID: 30601678.
      View in: PubMed   Mentions: 25     Fields:    
    67. Rapid Colorimetric Detection of Bacterial Species through the Capture of Gold Nanoparticles by Chimeric Phages. ACS Nano. 2019 02 26; 13(2):1244-1252. Peng H, Chen IA. PMID: 30586498; PMCID: PMC6396317.
      View in: PubMed   Mentions: 69     Fields:    Translation:Cells
    68. Lipid vesicles chaperone an encapsulated RNA aptamer. Nat Commun. 2018 06 13; 9(1):2313. Saha R, Verbanic S, Chen IA. PMID: 29899431; PMCID: PMC5998061.
      View in: PubMed   Mentions: 27     Fields:    Translation:Cells
    69. Analysis of Evolutionarily Independent Protein-RNA Complexes Yields a Criterion to Evaluate the Relevance of Prebiotic Scenarios. Curr Biol. 2018 02 19; 28(4):526-537.e5. Blanco C, Bayas M, Yan F, Chen IA. PMID: 29398222.
      View in: PubMed   Mentions: 26     Fields:    
    70. Analysis of in vitro evolution reveals the underlying distribution of catalytic activity among random sequences. Nucleic Acids Res. 2017 10 13; 45(18):10922. Pressman A, Moretti JE, Campbell GW, Müller UF, Chen IA. PMID: 28981710; PMCID: PMC5737358.
      View in: PubMed   Mentions: 3     Fields:    
    71. Analysis of in vitro evolution reveals the underlying distribution of catalytic activity among random sequences. Nucleic Acids Res. 2017 08 21; 45(14):8167-8179. Pressman A, Moretti JE, Campbell GW, Müller UF, Chen IA. PMID: 28645146; PMCID: PMC5737207.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    72. From underwear to non-equilibrium thermodynamics: physical chemistry informs the origin of life. Phys Chem Chem Phys. 2016 07 27; 18(30):20005-6. Chen IA, de Vries MS. PMID: 27388780.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    73. Computational analysis of fitness landscapes and evolutionary networks from in vitro evolution experiments. Methods. 2016 08 15; 106:86-96. Xulvi-Brunet R, Campbell GW, Rajamani S, Jiménez JI, Chen IA. PMID: 27211010; PMCID: PMC12054381.
      View in: PubMed   Mentions: 5     Fields:    
    74. Origin of Life: Protocells Red in Tooth and Claw. Curr Biol. 2015 Dec 21; 25(24):R1175-7. Saha R, Chen IA. PMID: 26702654.
      View in: PubMed   Mentions: 7     Fields:    
    75. The RNA World as a Model System to Study the Origin of Life. Curr Biol. 2015 Oct 05; 25(19):R953-63. Pressman A, Blanco C, Chen IA. PMID: 26439358.
      View in: PubMed   Mentions: 66     Fields:    
    76. Prebiotic chemistry: Replicating towards complexity. Nat Chem. 2015 Mar; 7(3):191-2. Chen IA. PMID: 25698324.
      View in: PubMed   Mentions: 2     Fields:    
    77. Molecular crowding and early evolution. Orig Life Evol Biosph. 2014 Dec; 44(4):319-24. Saha R, Pohorille A, Chen IA. PMID: 25585804.
      View in: PubMed   Mentions: 25     Fields:    
    78. Experimental fitness landscapes to understand the molecular evolution of RNA-based life. Curr Opin Chem Biol. 2014 Oct; 22:35-9. Athavale SS, Spicer B, Chen IA. PMID: 25270912.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    79. Genetic drift suppresses bacterial conjugation in spatially structured populations. Biophys J. 2014 Feb 18; 106(4):944-54. Freese PD, Korolev KS, Jiménez JI, Chen IA. PMID: 24559997; PMCID: PMC3944618.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    80. The paradox of dual roles in the RNA world: resolving the conflict between stable folding and templating ability. J Mol Evol. 2013 Sep; 77(3):55-63. Ivica NA, Obermayer B, Campbell GW, Rajamani S, Gerland U, Chen IA. PMID: 24078151; PMCID: PMC12051476.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    81. Comprehensive experimental fitness landscape and evolutionary network for small RNA. Proc Natl Acad Sci U S A. 2013 Sep 10; 110(37):14984-9. Jiménez JI, Xulvi-Brunet R, Campbell GW, Turk-MacLeod R, Chen IA. PMID: 23980164; PMCID: PMC3773786.
      View in: PubMed   Mentions: 78     Fields:    
    82. Selection for replicases in protocells. PLoS Comput Biol. 2013; 9(5):e1003051. Bianconi G, Zhao K, Chen IA, Nowak MA. PMID: 23671413; PMCID: PMC3649988.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    83. A population-based experimental model for protein evolution: effects of mutation rate and selection stringency on evolutionary outcomes. Biochemistry. 2013 Feb 26; 52(8):1490-9. Leconte AM, Dickinson BC, Yang DD, Chen IA, Allen B, Liu DR. PMID: 23360105; PMCID: PMC3641671.
      View in: PubMed   Mentions: 29     Fields:    Translation:Cells
    84. Cascade of reduced speed and accuracy after errors in enzyme-free copying of nucleic acid sequences. J Am Chem Soc. 2013 Jan 09; 135(1):354-66. Leu K, Kervio E, Obermayer B, Turk-MacLeod RM, Yuan C, Luevano JM, Chen E, Gerland U, Richert C, Chen IA. PMID: 23259600; PMCID: PMC3557965.
      View in: PubMed   Mentions: 33     Fields:    Translation:Cells
    85. Spontaneous network formation among cooperative RNA replicators. Nature. 2012 Nov 01; 491(7422):72-7. Vaidya N, Manapat ML, Chen IA, Xulvi-Brunet R, Hayden EJ, Lehman N. PMID: 23075853.
      View in: PubMed   Mentions: 146     Fields:    Translation:Cells
    86. From prelife to life: how chemical kinetics become evolutionary dynamics. Acc Chem Res. 2012 Dec 18; 45(12):2088-96. Chen IA, Nowak MA. PMID: 22335792; PMCID: PMC4610729.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    87. Prebiotically plausible mechanisms increase compositional diversity of nucleic acid sequences. Nucleic Acids Res. 2012 May; 40(10):4711-22. Derr J, Manapat ML, Rajamani S, Leu K, Xulvi-Brunet R, Joseph I, Nowak MA, Chen IA. PMID: 22319215; PMCID: PMC3378899.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    88. The prebiotic evolutionary advantage of transferring genetic information from RNA to DNA. Nucleic Acids Res. 2011 Oct; 39(18):8135-47. Leu K, Obermayer B, Rajamani S, Gerland U, Chen IA. PMID: 21724606; PMCID: PMC3185426.
      View in: PubMed   Mentions: 38     Fields:    Translation:Cells
    89. Inhibition of bacterial conjugation by phage M13 and its protein g3p: quantitative analysis and model. PLoS One. 2011; 6(5):e19991. Lin A, Jimenez J, Derr J, Vera P, Manapat ML, Esvelt KM, Villanueva L, Liu DR, Chen IA. PMID: 21637841; PMCID: PMC3102678.
      View in: PubMed   Mentions: 52     Fields:    Translation:Cells
    90. Quadruplet codons: one small step for a ribosome, one giant leap for proteins: an expanded genetic code could address fundamental questions about algorithmic information, biological function, and the origins of life. Bioessays. 2010 Aug; 32(8):650-4. Chen IA, Schindlinger M. PMID: 20658702; PMCID: PMC3133615.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    91. From self-assembled vesicles to protocells. Cold Spring Harb Perspect Biol. 2010 Jul; 2(7):a002170. Chen IA, Walde P. PMID: 20519344; PMCID: PMC2890201.
      View in: PubMed   Mentions: 84     Fields:    Translation:Cells
    92. Effect of stalling after mismatches on the error catastrophe in nonenzymatic nucleic acid replication. J Am Chem Soc. 2010 Apr 28; 132(16):5880-5. Rajamani S, Ichida JK, Antal T, Treco DA, Leu K, Nowak MA, Szostak JW, Chen IA. PMID: 20359213; PMCID: PMC2857888.
      View in: PubMed   Mentions: 60     Fields:    Translation:Cells
    93. The basic reproductive ratio of life. J Theor Biol. 2010 Apr 07; 263(3):317-27. Manapat ML, Chen IA, Nowak MA. PMID: 20034501; PMCID: PMC2827768.
      View in: PubMed   Mentions: 8     Fields:    
    94. Cell division: breaking up is easy to do. Curr Biol. 2009 Apr 28; 19(8):R327-8. Chen IA. PMID: 19409280.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    95. GE Prize-winning essay. The emergence of cells during the origin of life. Science. 2006 Dec 08; 314(5805):1558-9. Chen IA. PMID: 17158315.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    96. Shrink-wrap vesicles. Langmuir. 2005 Dec 20; 21(26):12124-9. Fujikawa SM, Chen IA, Szostak JW. PMID: 16342983; PMCID: PMC2548281.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    97. RNA catalysis in model protocell vesicles. J Am Chem Soc. 2005 Sep 28; 127(38):13213-9. Chen IA, Salehi-Ashtiani K, Szostak JW. PMID: 16173749; PMCID: PMC5072289.
      View in: PubMed   Mentions: 99     Fields:    Translation:Cells
    98. The emergence of competition between model protocells. Science. 2004 Sep 03; 305(5689):1474-6. Chen IA, Roberts RW, Szostak JW. PMID: 15353806; PMCID: PMC4484590.
      View in: PubMed   Mentions: 141     Fields:    Translation:Cells
    99. A kinetic study of the growth of fatty acid vesicles. Biophys J. 2004 Aug; 87(2):988-98. Chen IA, Szostak JW. PMID: 15298905; PMCID: PMC1304506.
      View in: PubMed   Mentions: 74     Fields:    
    100. Membrane growth can generate a transmembrane pH gradient in fatty acid vesicles. Proc Natl Acad Sci U S A. 2004 May 25; 101(21):7965-70. Chen IA, Szostak JW. PMID: 15148394; PMCID: PMC419540.
      View in: PubMed   Mentions: 57     Fields:    Translation:Cells
    101. A strategically positioned cation is crucial for efficient catalysis by chorismate mutase. J Biol Chem. 2000 Nov 24; 275(47):36832-8. Kast P, Grisostomi C, Chen IA, Li S, Krengel U, Xue Y, Hilvert D. PMID: 10960481.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    Irene's Networks
    Concepts (272)
    Derived automatically from this person's publications.
    Explore
    _
    Co-Authors (37)
    People in Profiles who have published with this person.
    Explore
    _
    Similar People (60)
    People who share similar concepts with this person.
    Explore
    _

    UCLA Profiles is managed by the UCSF Clinical and Translational Science Institute (CTSI), part of the Clinical and Translational Science Award program funded by the National Center for Advancing Translational Sciences (Grant Number UL1 TR000004) at the National Institutes of Health (NIH).
    This site is running Profiles RNS version UCSF-v3.1.0-40-gb10dcd06 on PROFILES-PWEB04. We use cookies to operate our website. We also use cookies to analyze our site’s performance and improve your experience on our site. For more information about how we use cookies, please see our Website Terms of Use.

    Copyright © The Regents of the University of California