Peter John Bradley

Title(s)Professor, MIMG
SchoolMedicine
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    An unnatural amino acid system for capturing protein-protein interactions in Toxoplasma gondii
    NIH R21AI135661Jan 15, 2019 - Dec 31, 2020
    Role: Principal Investigator
    Functional Analysis of Novel Components of the Toxoplasma Inner Membrane Complex
    NIH R01AI123360Aug 1, 2017 - Jul 31, 2021
    Role: Principal Investigator
    Novel Dense Granule Protein Function in the Chronic Toxoplasma Infection
    NIH R21AI125106Feb 10, 2016 - Jan 31, 2019
    Role: Principal Investigator
    Reconstitution of Plasmodium Export in Toxoplasma
    NIH R03AI101749May 1, 2012 - Apr 30, 2015
    Role: Principal Investigator
    Novel rhoptry effector proteins in Toxoplasma host-pathogen interaction
    NIH R21AI098070Feb 15, 2012 - Jan 31, 2015
    Role: Principal Investigator
    The Role of Toxoplasma Rhoptries in Host Cell Infection
    NIH R01AI064616Dec 15, 2005 - Jan 31, 2018
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Multivalent Interactions Drive the Toxoplasma AC9:AC10:ERK7 Complex To Concentrate ERK7 in the Apical Cap. mBio. 2022 Feb 08; e0286421. Back PS, O'Shaughnessy WJ, Moon AS, Dewangan PS, Reese ML, Bradley PJ. PMID: 35130732; PMCID: PMC8822341.
      View in: PubMed   Mentions: 1     Fields:    
    2. Efficient Gene Knockout and Knockdown Systems in Neospora caninum Enable Rapid Discovery and Functional Assessment of Novel Proteins. mSphere. 2022 02 23; 7(1):e0089621. Mineo TWP, Chern JH, Thind AC, Mota CM, Nadipuram SM, Torres JA, Bradley PJ. PMID: 35019667; PMCID: PMC8754167.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    3. A Novel Toxoplasma Inner Membrane Complex Suture-Associated Protein Regulates Suture Protein Targeting and Colocalizes with Membrane Trafficking Machinery. mBio. 2021 10 26; 12(5):e0245521. Chern JH, Pasquarelli RR, Moon AS, Chen AL, Sha J, Wohlschlegel JA, Bradley PJ. PMID: 34634933; PMCID: PMC8510555.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    4. Identification and Molecular Dissection of IMC32, a Conserved Toxoplasma Inner Membrane Complex Protein That Is Essential for Parasite Replication. mBio. 2021 02 16; 12(1). Torres JA, Pasquarelli RR, Back PS, Moon AS, Bradley PJ. PMID: 33593973; PMCID: PMC8545131.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    5. Ancient MAPK ERK7 is regulated by an unusual inhibitory scaffold required for Toxoplasma apical complex biogenesis. Proc Natl Acad Sci U S A. 2020 06 02; 117(22):12164-12173. Back PS, O'Shaughnessy WJ, Moon AS, Dewangan PS, Hu X, Sha J, Wohlschlegel JA, Bradley PJ, Reese ML. PMID: 32409604; PMCID: PMC7275706.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    6. Proximity biotinylation reveals novel secreted dense granule proteins of Toxoplasma gondii bradyzoites. PLoS One. 2020; 15(5):e0232552. Nadipuram SM, Thind AC, Rayatpisheh S, Wohlschlegel JA, Bradley PJ. PMID: 32374791; PMCID: PMC7202600.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    7. Using BioID for the Identification of Interacting and Proximal Proteins in Subcellular Compartments in Toxoplasma gondii. Methods Mol Biol. 2020; 2071:323-346. Bradley PJ, Rayatpisheh S, Wohlschlegel JA, Nadipuram SM. PMID: 31758461.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    8. A photoactivatable crosslinking system reveals protein interactions in the Toxoplasma gondii inner membrane complex. PLoS Biol. 2019 10; 17(10):e3000475. Choi CP, Moon AS, Back PS, Jami-Alahmadi Y, Vashisht AA, Wohlschlegel JA, Bradley PJ. PMID: 31584943; PMCID: PMC6795473.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    9. A lipid-binding protein mediates rhoptry discharge and invasion in Plasmodium falciparum and Toxoplasma gondii parasites. Nat Commun. 2019 09 06; 10(1):4041. Suarez C, Lentini G, Ramaswamy R, Maynadier M, Aquilini E, Berry-Sterkers L, Cipriano M, Chen AL, Bradley P, Striepen B, Boulanger MJ, Lebrun M. PMID: 31492901; PMCID: PMC6731292.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    10. Corrigendum: Neospora Caninum Activates p38 MAPK as an Evasion Mechanism against Innate Immunity. Front Microbiol. 2019; 10:548. Mota CM, Oliveira ACM, Davoli-Ferreira M, Silva MV, Santiago FM, Nadipuram SM, Vashisht AA, Wohlschlegel JA, Bradley PJ, Silva JS, Mineo JR, Mineo TWP. PMID: 30972042; PMCID: PMC6444170.
      View in: PubMed   Mentions: 1  
    11. Retraction Note: New molecular tools in Neospora caninum for studying apicomplexan parasite proteins. Sci Rep. 2018 07 13; 8(1):10964. Mota CM, Chen AL, Wang K, Nadipuram S, Vashisht AA, Wohlschlegel JA, Mineo TWP, Bradley PJ. PMID: 30006618; PMCID: PMC6045672.
      View in: PubMed   Mentions:    Fields:    
    12. New molecular tools in Neospora caninum for studying apicomplexan parasite proteins. Sci Rep. 2017 06 19; 7(1):3768. Mota CM, Chen AL, Wang K, Nadipuram S, Vashisht AA, Wohlschlegel JA, Mineo TWP, Bradley PJ. PMID: 28630403; PMCID: PMC5476669.
      View in: PubMed   Mentions: 1     Fields:    
    13. Novel insights into the composition and function of the Toxoplasma IMC sutures. Cell Microbiol. 2017 04; 19(4). Chen AL, Moon AS, Bell HN, Huang AS, Vashisht AA, Toh JY, Lin AH, Nadipuram SM, Kim EW, Choi CP, Wohlschlegel JA, Bradley PJ. PMID: 27696623; PMCID: PMC5909696.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    14. Neospora caninum Activates p38 MAPK as an Evasion Mechanism against Innate Immunity. Front Microbiol. 2016; 7:1456. Mota CM, Oliveira AC, Davoli-Ferreira M, Silva MV, Santiago FM, Nadipuram SM, Vashisht AA, Wohlschlegel JA, Bradley PJ, Silva JS, Mineo JR, Mineo TW. PMID: 27679624; PMCID: PMC5020094.
      View in: PubMed   Mentions: 17  
    15. In Vivo Biotinylation of the Toxoplasma Parasitophorous Vacuole Reveals Novel Dense Granule Proteins Important for Parasite Growth and Pathogenesis. mBio. 2016 08 02; 7(4). Nadipuram SM, Kim EW, Vashisht AA, Lin AH, Bell HN, Coppens I, Wohlschlegel JA, Bradley PJ. PMID: 27486190; PMCID: PMC4981711.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    16. The Rhoptry Pseudokinase ROP54 Modulates Toxoplasma gondii Virulence and Host GBP2 Loading. mSphere. 2016 Mar-Apr; 1(2). Kim EW, Nadipuram SM, Tetlow AL, Barshop WD, Liu PT, Wohlschlegel JA, Bradley PJ. PMID: 27303719; PMCID: PMC4863586.
      View in: PubMed   Mentions: 12     Fields:    
    17. Identification of Novel O-Linked Glycosylated Toxoplasma Proteins by Vicia villosa Lectin Chromatography. PLoS One. 2016; 11(3):e0150561. Wang K, Peng ED, Huang AS, Xia D, Vermont SJ, Lentini G, Lebrun M, Wastling JM, Bradley PJ. PMID: 26950937; PMCID: PMC4780768.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    18. The Ubiquitin Proteome of Toxoplasma gondii Reveals Roles for Protein Ubiquitination in Cell-Cycle Transitions. Cell Host Microbe. 2015 Nov 11; 18(5):621-33. Silmon de Monerri NC, Yakubu RR, Chen AL, Bradley PJ, Nieves E, Weiss LM, Kim K. PMID: 26567513; PMCID: PMC4968887.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    19. Three-dimensional coherent X-ray diffractive imaging of whole frozen-hydrated cells. IUCrJ. 2015 Sep 01; 2(Pt 5):575-83. Rodriguez JA, Xu R, Chen CC, Huang Z, Jiang H, Chen AL, Raines KS, Pryor A, Nam D, Wiegart L, Song C, Madsen A, Chushkin Y, Zontone F, Bradley PJ, Miao J. PMID: 26306199; PMCID: PMC4547825.
      View in: PubMed   Mentions: 21  
    20. The Toxoplasma Dense Granule Proteins GRA17 and GRA23 Mediate the Movement of Small Molecules between the Host and the Parasitophorous Vacuole. Cell Host Microbe. 2015 May 13; 17(5):642-52. Gold DA, Kaplan AD, Lis A, Bett GC, Rosowski EE, Cirelli KM, Bougdour A, Sidik SM, Beck JR, Lourido S, Egea PF, Bradley PJ, Hakimi MA, Rasmusson RL, Saeij JP. PMID: 25974303; PMCID: PMC4435723.
      View in: PubMed   Mentions: 105     Fields:    Translation:AnimalsCells
    21. Novel components of the Toxoplasma inner membrane complex revealed by BioID. mBio. 2015 Feb 17; 6(1):e02357-14. Chen AL, Kim EW, Toh JY, Vashisht AA, Rashoff AQ, Van C, Huang AS, Moon AS, Bell HN, Bentolila LA, Wohlschlegel JA, Bradley PJ. PMID: 25691595; PMCID: PMC4337574.
      View in: PubMed   Mentions: 81     Fields:    Translation:AnimalsCells
    22. The inner membrane complex sub-compartment proteins critical for replication of the apicomplexan parasite Toxoplasma gondii adopt a pleckstrin homology fold. J Biol Chem. 2014 May 16; 289(20):13962-73. Tonkin ML, Beck JR, Bradley PJ, Boulanger MJ. PMID: 24675080; PMCID: PMC4022867.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    23. RON5 is critical for organization and function of the Toxoplasma moving junction complex. PLoS Pathog. 2014 Mar; 10(3):e1004025. Beck JR, Chen AL, Kim EW, Bradley PJ. PMID: 24651769; PMCID: PMC3961375.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    24. Small-molecule inhibition of a depalmitoylase enhances Toxoplasma host-cell invasion. Nat Chem Biol. 2013 Oct; 9(10):651-6. Child MA, Hall CI, Beck JR, Ofori LO, Albrow VE, Garland M, Bowyer PW, Bradley PJ, Powers JC, Boothroyd JC, Weerapana E, Bogyo M. PMID: 23934245; PMCID: PMC3832678.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    25. A SAS-6-like protein suggests that the Toxoplasma conoid complex evolved from flagellar components. Eukaryot Cell. 2013 Jul; 12(7):1009-19. de Leon JC, Scheumann N, Beatty W, Beck JR, Tran JQ, Yau C, Bradley PJ, Gull K, Wickstead B, Morrissette NS. PMID: 23687115; PMCID: PMC3697468.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    26. A Toxoplasma palmitoyl acyl transferase and the palmitoylated armadillo repeat protein TgARO govern apical rhoptry tethering and reveal a critical role for the rhoptries in host cell invasion but not egress. PLoS Pathog. 2013 Feb; 9(2):e1003162. Beck JR, Fung C, Straub KW, Coppens I, Vashisht AA, Wohlschlegel JA, Bradley PJ. PMID: 23408890; PMCID: PMC3567180.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    27. Purification, crystallization and preliminary X-ray diffraction analysis of inner membrane complex (IMC) subcompartment protein 1 (ISP1) from Toxoplasma gondii. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jul 01; 68(Pt 7):832-4. Tonkin ML, Brown S, Beck JR, Bradley PJ, Boulanger MJ. PMID: 22750877; PMCID: PMC3388934.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    28. Toxoplasma ISP4 is a central IMC sub-compartment protein whose localization depends on palmitoylation but not myristoylation. Mol Biochem Parasitol. 2012 Aug; 184(2):99-108. Fung C, Beck JR, Robertson SD, Gubbels MJ, Bradley PJ. PMID: 22659420; PMCID: PMC3383393.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    29. Cytoskeleton assembly in Toxoplasma gondii cell division. Int Rev Cell Mol Biol. 2012; 298:1-31. Anderson-White B, Beck JR, Chen CT, Meissner M, Bradley PJ, Gubbels MJ. PMID: 22878103; PMCID: PMC4066374.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    30. Molecular dissection of novel trafficking and processing of the Toxoplasma gondii rhoptry metalloprotease toxolysin-1. Traffic. 2012 Feb; 13(2):292-304. Hajagos BE, Turetzky JM, Peng ED, Cheng SJ, Ryan CM, Souda P, Whitelegge JP, Lebrun M, Dubremetz JF, Bradley PJ. PMID: 22035499; PMCID: PMC3375832.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    31. Identification of potential serodiagnostic and subunit vaccine antigens by antibody profiling of toxoplasmosis cases in Turkey. Mol Cell Proteomics. 2011 Jul; 10(7):M110.006916. Liang L, Döskaya M, Juarez S, Caner A, Jasinskas A, Tan X, Hajagos BE, Bradley PJ, Korkmaz M, Gürüz Y, Felgner PL, Davies DH. PMID: 21512035; PMCID: PMC3134070.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    32. Identification of novel proteins in Neospora caninum using an organelle purification and monoclonal antibody approach. PLoS One. 2011 Apr 04; 6(4):e18383. Sohn CS, Cheng TT, Drummond ML, Peng ED, Vermont SJ, Xia D, Cheng SJ, Wastling JM, Bradley PJ. PMID: 21483743; PMCID: PMC3070720.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    33. The moving junction protein RON8 facilitates firm attachment and host cell invasion in Toxoplasma gondii. PLoS Pathog. 2011 Mar; 7(3):e1002007. Straub KW, Peng ED, Hajagos BE, Tyler JS, Bradley PJ. PMID: 21423671; PMCID: PMC3053350.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    34. A novel family of Toxoplasma IMC proteins displays a hierarchical organization and functions in coordinating parasite division. PLoS Pathog. 2010 Sep 09; 6(9):e1001094. Beck JR, Rodriguez-Fernandez IA, de Leon JC, Huynh MH, Carruthers VB, Morrissette NS, Bradley PJ. PMID: 20844581; PMCID: PMC2936552.
      View in: PubMed   Mentions: 118     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    35. Processing and secretion of ROP13: A unique Toxoplasma effector protein. Int J Parasitol. 2010 Aug 01; 40(9):1037-44. Turetzky JM, Chu DK, Hajagos BE, Bradley PJ. PMID: 20359481; PMCID: PMC2918400.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    36. A dynamin is required for the biogenesis of secretory organelles in Toxoplasma gondii. Curr Biol. 2009 Feb 24; 19(4):277-86. Breinich MS, Ferguson DJ, Foth BJ, van Dooren GG, Lebrun M, Quon DV, Striepen B, Bradley PJ, Frischknecht F, Carruthers VB, Meissner M. PMID: 19217293; PMCID: PMC3941470.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    37. Novel components of the Apicomplexan moving junction reveal conserved and coccidia-restricted elements. Cell Microbiol. 2009 Apr; 11(4):590-603. Straub KW, Cheng SJ, Sohn CS, Bradley PJ. PMID: 19134112; PMCID: PMC2798130.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    38. Intervacuolar transport and unique topology of GRA14, a novel dense granule protein in Toxoplasma gondii. Infect Immun. 2008 Nov; 76(11):4865-75. Rome ME, Beck JR, Turetzky JM, Webster P, Bradley PJ. PMID: 18765740; PMCID: PMC2573327.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    39. A thioredoxin family protein of the apicoplast periphery identifies abundant candidate transport vesicles in Toxoplasma gondii. Eukaryot Cell. 2008 Sep; 7(9):1518-29. DeRocher AE, Coppens I, Karnataki A, Gilbert LA, Rome ME, Feagin JE, Bradley PJ, Parsons M. PMID: 18586952; PMCID: PMC2547066.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    40. Rhoptries: an arsenal of secreted virulence factors. Curr Opin Microbiol. 2007 Dec; 10(6):582-7. Bradley PJ, Sibley LD. PMID: 17997128; PMCID: PMC2682365.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    41. Toxoplasma gondii targets a protein phosphatase 2C to the nuclei of infected host cells. Eukaryot Cell. 2007 Jan; 6(1):73-83. Gilbert LA, Ravindran S, Turetzky JM, Boothroyd JC, Bradley PJ. PMID: 17085638; PMCID: PMC1800361.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    42. The rhoptry neck protein RON4 re-localizes at the moving junction during Toxoplasma gondii invasion. Cell Microbiol. 2005 Dec; 7(12):1823-33. Lebrun M, Michelin A, El Hajj H, Poncet J, Bradley PJ, Vial H, Dubremetz JF. PMID: 16309467.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansAnimalsCells
    43. Identification of the moving junction complex of Toxoplasma gondii: a collaboration between distinct secretory organelles. PLoS Pathog. 2005 Oct; 1(2):e17. Alexander DL, Mital J, Ward GE, Bradley P, Boothroyd JC. PMID: 16244709; PMCID: PMC1262624.
      View in: PubMed   Mentions: 173     Fields:    Translation:AnimalsCells
    44. Proteomic analysis of rhoptry organelles reveals many novel constituents for host-parasite interactions in Toxoplasma gondii. J Biol Chem. 2005 Oct 07; 280(40):34245-58. Bradley PJ, Ward C, Cheng SJ, Alexander DL, Coller S, Coombs GH, Dunn JD, Ferguson DJ, Sanderson SJ, Wastling JM, Boothroyd JC. PMID: 16002398.
      View in: PubMed   Mentions: 176     Fields:    Translation:AnimalsCells
    45. A GFP-based motif-trap reveals a novel mechanism of targeting for the Toxoplasma ROP4 protein. Mol Biochem Parasitol. 2004 Sep; 137(1):111-20. Bradley PJ, Li N, Boothroyd JC. PMID: 15279957.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    46. Unprocessed Toxoplasma ROP1 is effectively targeted and secreted into the nascent parasitophorous vacuole. Mol Biochem Parasitol. 2002 Nov-Dec; 125(1-2):189-93. Bradley PJ, Hsieh CL, Boothroyd JC. PMID: 12467986.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
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