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Shehla Pervin

Title(s)Associate Professor-in-Residence, Obstetrics and Gynecology
SchoolMedicine
Phone(310) 490-4630
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    Collapse Research 
    Collapse Research Activities and Funding
    Beige Adipocytes and African American Breast Tumors
    NIH/NCI SC1CA232319Jul 6, 2018 - Jun 30, 2022
    Role: Principal Investigator
    Targeting pERK1/2 in Human Mammary Cancer Stem Cells
    NIH/NCI SC1CA165865Jul 11, 2011 - Jun 30, 2016
    Role: Principal Investigator
    Drew National High School Student Summer Research Apprentice Program
    NIH/NIDDK R25DK078384Aug 1, 2009 - May 21, 2011
    Role: Co-Principal Investigator
    p38 MAP Kinase and Akt Interaction in HUVEC
    NIH/NICHD R03HD053888Jun 1, 2007 - May 31, 2009
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Singh R, Pervin S, Lee SJ, Kuo A, Grijalva V, David J, Vergnes L, Reddy ST. Metabolic profiling of follistatin overexpression: a novel therapeutic strategy for metabolic diseases. Diabetes Metab Syndr Obes. 2018; 11:65-84. PMID: 29618935.
      View in: PubMed
    2. Pervin S, Singh V, Tucker A, Collazo J, Singh R. Modulation of transforming growth factor-ß/follistatin signaling and white adipose browning: therapeutic implications for obesity related disorders. Horm Mol Biol Clin Investig. 2017 Sep 09; 31(2). PMID: 28888087.
      View in: PubMed
    3. Singh R, Braga M, Reddy ST, Lee SJ, Parveen M, Grijalva V, Vergnes L, Pervin S. Follistatin Targets Distinct Pathways To Promote Brown Adipocyte Characteristics in Brown and White Adipose Tissues. Endocrinology. 2017 05 01; 158(5):1217-1230. PMID: 28324027.
      View in: PubMed
    4. Howard CB, McDowell R, Feleke K, Deer E, Stamps S, Thames E, Singh V, Pervin S. Chemotherapeutic Vulnerability of Triple-negative Breast Cancer Cell-derived Tumors to Pretreatment with Vernonia amygdalina Aqueous Extracts. Anticancer Res. 2016 Aug; 36(8):3933-43. PMID: 27466496.
      View in: PubMed
    5. Martinez L, Thames E, Kim J, Chaudhuri G, Singh R, Pervin S. Increased sensitivity of African American triple negative breast cancer cells to nitric oxide-induced mitochondria-mediated apoptosis. BMC Cancer. 2016 07 29; 16:559. PMID: 27473585.
      View in: PubMed
    6. Howard CB, Johnson WK, Pervin S, Izevbigie EB. Recent perspectives on the anticancer properties of aqueous extracts of Nigerian Vernonia amygdalina. Botanics. 2015; 5:65-76. PMID: 27226742.
      View in: PubMed
    7. Singh R, Parveen M, Basgen JM, Fazel S, Meshesha MF, Thames EC, Moore B, Martinez L, Howard CB, Vergnes L, Reue K, Pervin S. Increased Expression of Beige/Brown Adipose Markers from Host and Breast Cancer Cells Influence Xenograft Formation in Mice. Mol Cancer Res. 2016 Jan; 14(1):78-92. PMID: 26464213.
      View in: PubMed
    8. Singh R, Braga M, Pervin S. Regulation of brown adipocyte metabolism by myostatin/follistatin signaling. Front Cell Dev Biol. 2014; 2:60. PMID: 25364764.
      View in: PubMed
    9. Braga M, Reddy ST, Vergnes L, Pervin S, Grijalva V, Stout D, David J, Li X, Tomasian V, Reid CB, Norris KC, Devaskar SU, Reue K, Singh R. Follistatin promotes adipocyte differentiation, browning, and energy metabolism. J Lipid Res. 2014 Mar; 55(3):375-84. PMID: 24443561.
      View in: PubMed
    10. Singh R, Avliyakulov NK, Braga M, Haykinson MJ, Martinez L, Singh V, Parveen M, Chaudhuri G, Pervin S. Proteomic identification of mitochondrial targets of arginase in human breast cancer. PLoS One. 2013; 8(11):e79242. PMID: 24223914.
      View in: PubMed
    11. Braga M, Pervin S, Norris K, Bhasin S, Singh R. Inhibition of in vitro and in vivo brown fat differentiation program by myostatin. Obesity (Silver Spring). 2013 Jun; 21(6):1180-8. PMID: 23868854.
      View in: PubMed
    12. Pervin S, Tran L, Urman R, Braga M, Parveen M, Li SA, Chaudhuri G, Singh R. Oxidative stress specifically downregulates survivin to promote breast tumour formation. Br J Cancer. 2013 Mar 05; 108(4):848-58. PMID: 23403820.
      View in: PubMed
    13. Pervin S, Hewison M, Braga M, Tran L, Chun R, Karam A, Chaudhuri G, Norris K, Singh R. Down-regulation of vitamin D receptor in mammospheres: implications for vitamin D resistance in breast cancer and potential for combination therapy. PLoS One. 2013; 8(1):e53287. PMID: 23341935.
      View in: PubMed
    14. Braga M, Bhasin S, Jasuja R, Pervin S, Singh R. Testosterone inhibits transforming growth factor-ß signaling during myogenic differentiation and proliferation of mouse satellite cells: potential role of follistatin in mediating testosterone action. Mol Cell Endocrinol. 2012 Mar 05; 350(1):39-52. PMID: 22138414.
      View in: PubMed
    15. Pervin S, Tran A, Tran L, Urman R, Braga M, Chaudhuri G, Singh R. Reduced association of anti-apoptotic protein Mcl-1 with E3 ligase Mule increases the stability of Mcl-1 in breast cancer cells. Br J Cancer. 2011 Jul 26; 105(3):428-37. PMID: 21730980.
      View in: PubMed
    16. Pervin S, Chaudhuri G, Singh R. NO to breast: when, why and why not? Curr Pharm Des. 2010; 16(4):451-62. PMID: 20236074.
      View in: PubMed
    17. Miranda-Carboni GA, Krum SA, Yee K, Nava M, Deng QE, Pervin S, Collado-Hidalgo A, Galic Z, Zack JA, Nakayama K, Nakayama KI, Lane TF. A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors. Genes Dev. 2008 Nov 15; 22(22):3121-34. PMID: 19056892.
      View in: PubMed
    18. Singh R, Bhasin S, Braga M, Artaza JN, Pervin S, Taylor WE, Krishnan V, Sinha SK, Rajavashisth TB, Jasuja R. Regulation of myogenic differentiation by androgens: cross talk between androgen receptor/ beta-catenin and follistatin/transforming growth factor-beta signaling pathways. Endocrinology. 2009 Mar; 150(3):1259-68. PMID: 18948405.
      View in: PubMed
    19. Pervin S, Tran AH, Zekavati S, Fukuto JM, Singh R, Chaudhuri G. Increased susceptibility of breast cancer cells to stress mediated inhibition of protein synthesis. Cancer Res. 2008 Jun 15; 68(12):4862-74. PMID: 18559534.
      View in: PubMed
    20. Pervin S, Singh R, Chaudhuri G. Nitric oxide, N omega-hydroxy-L-arginine and breast cancer. Nitric Oxide. 2008 Sep; 19(2):103-6. PMID: 18474257.
      View in: PubMed
    21. Pervin S, Singh R, Hernandez E, Wu G, Chaudhuri G. Nitric oxide in physiologic concentrations targets the translational machinery to increase the proliferation of human breast cancer cells: involvement of mammalian target of rapamycin/eIF4E pathway. Cancer Res. 2007 Jan 01; 67(1):289-99. PMID: 17210710.
      View in: PubMed
    22. Pervin S, Singh R, Freije WA, Chaudhuri G. MKP-1-induced dephosphorylation of extracellular signal-regulated kinase is essential for triggering nitric oxide-induced apoptosis in human breast cancer cell lines: implications in breast cancer. Cancer Res. 2003 Dec 15; 63(24):8853-60. PMID: 14695202.
      View in: PubMed
    23. Pervin S, Singh R, Chaudhuri G. Nitric-oxide-induced Bax integration into the mitochondrial membrane commits MDA-MB-468 cells to apoptosis: essential role of Akt. Cancer Res. 2003 Sep 01; 63(17):5470-9. PMID: 14500383.
      View in: PubMed
    24. Singh R, Pervin S, Chaudhuri G. Caspase-8-mediated BID cleavage and release of mitochondrial cytochrome c during Nomega-hydroxy-L-arginine-induced apoptosis in MDA-MB-468 cells. Antagonistic effects of L-ornithine. J Biol Chem. 2002 Oct 04; 277(40):37630-6. PMID: 12145284.
      View in: PubMed
    25. Singh R, Pervin S, Wu G, Chaudhuri G. Activation of caspase-3 activity and apoptosis in MDA-MB-468 cells by N(omega)-hydroxy-L-arginine, an inhibitor of arginase, is not solely dependent on reduction in intracellular polyamines. Carcinogenesis. 2001 Nov; 22(11):1863-9. PMID: 11698350.
      View in: PubMed
    26. Pervin S, Singh R, Gau CL, Edamatsu H, Tamanoi F, Chaudhuri G. Potentiation of nitric oxide-induced apoptosis of MDA-MB-468 cells by farnesyltransferase inhibitor: implications in breast cancer. Cancer Res. 2001 Jun 15; 61(12):4701-6. PMID: 11406540.
      View in: PubMed
    27. Pervin S, Singh R, Chaudhuri G. Nitric oxide-induced cytostasis and cell cycle arrest of a human breast cancer cell line (MDA-MB-231): potential role of cyclin D1. Proc Natl Acad Sci U S A. 2001 Mar 13; 98(6):3583-8. PMID: 11248121.
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    28. Singh R, Pervin S, Karimi A, Cederbaum S, Chaudhuri G. Arginase activity in human breast cancer cell lines: N(omega)-hydroxy-L-arginine selectively inhibits cell proliferation and induces apoptosis in MDA-MB-468 cells. Cancer Res. 2000 Jun 15; 60(12):3305-12. PMID: 10866325.
      View in: PubMed
    29. Singh R, Pervin S, Shryne J, Gorski R, Chaudhuri G. Castration increases and androgens decrease nitric oxide synthase activity in the brain: physiologic implications. Proc Natl Acad Sci U S A. 2000 Mar 28; 97(7):3672-7. PMID: 10725371.
      View in: PubMed
    30. Nathan L, Pervin S, Singh R, Rosenfeld M, Chaudhuri G. Estradiol inhibits leukocyte adhesion and transendothelial migration in rabbits in vivo : possible mechanisms for gender differences in atherosclerosis. Circ Res. 1999 Aug 20; 85(4):377-85. PMID: 10455066.
      View in: PubMed
    31. Pervin S, Singh R, Rosenfeld ME, Navab M, Chaudhuri G, Nathan L. Estradiol suppresses MCP-1 expression In vivo : implications for atherosclerosis. Arterioscler Thromb Vasc Biol. 1998 Oct; 18(10):1575-82. PMID: 9763529.
      View in: PubMed
    32. Zhang RS, Guth PH, Scremin OU, Singh R, Pervin S, Chaudhuri G. Regulation of endometrial blood flow in ovariectomized rats: assessment of the role of nitric oxide. Am J Physiol. 1997 10; 273(4):H2009-17. PMID: 9362273.
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    33. Singh R, Pervin S, Rogers NE, Ignarro LJ, Chaudhuri G. Evidence for the presence of an unusual nitric oxide- and citrulline-producing enzyme in rat kidney. Biochem Biophys Res Commun. 1997 Mar 27; 232(3):672-7. PMID: 9126334.
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    34. Pervin S, Chakraborty M, Bhattacharya-Chatterjee M, Zeytin H, Foon KA, Chatterjee SK. Induction of antitumor immunity by an anti-idiotype antibody mimicking carcinoembryonic antigen. Cancer Res. 1997 Feb 15; 57(4):728-34. PMID: 9044852.
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    35. Buga GM, Singh R, Pervin S, Rogers NE, Schmitz DA, Jenkinson CP, Cederbaum SD, Ignarro LJ. Arginase activity in endothelial cells: inhibition by NG-hydroxy-L-arginine during high-output NO production. Am J Physiol. 1996 Nov; 271(5 Pt 2):H1988-98. PMID: 8945918.
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