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Sternini, Catia

Title(s)Professor-in-Residence, Medicine
SchoolDigestive Diseases
Phone56526
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    Other Positions
    Title(s)Professor-in-Residence, Neurobiology


    Collapse Research 
    Collapse Research Activities and Funding
    Extragustatory Functions of Bitter Taste Receptors
    NIH/NIDDK R01DK098447Apr 15, 2015 - Mar 31, 2019
    Role: Principal Investigator
    Mu opioid receptor function in the enteric nervous system
    NIH/NIDDK R01DK054155Feb 15, 2010 - Jun 30, 2013
    Role: Principal Investigator
    Chemosensing in the Gastrointestinal Tract
    NIH/NIDDK R01DK079155Sep 15, 2009 - Jun 30, 2012
    Role: Principal Investigator
    ROLE OF GALANIN RECEPTORS IN GASTROINTESTINAL MOTILITY
    NIH/NIDDK R01DK057037Sep 1, 2000 - Sep 30, 2008
    Role: Principal Investigator
    Mu Opioid Receptor Function in the Enteric Nervous System
    NIH/NIDDK R56DK054155Jan 1, 1998 - Aug 31, 2015
    Role: Principal Investigator
    SENSORY AFFERENT INNERVATION OF THE DIGESTIVE SYSTEM
    NIH/NIDDK R01DK040469Aug 1, 1988 - Jul 31, 1992
    Role: Principal Investigator
    ORGANIZATION AND EXPRESSION OF CGRP IN THE PANCREAS
    NIH/NIDDK R01DK038752Jun 15, 1987 - May 31, 1994
    Role: Principal Investigator
    GASTRIC NEUROPEPTIDASES/PEPTIDE RECEPTOR INTERACTIONS
    NIH/NIDDK R01DK035740Aug 1, 1985 - Jul 31, 2004
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Boschetti E, Malagelada C, Accarino A, Malagelada JR, Cogliandro RF, Gori A, Bonora E, Giancola F, Bianco F, Tugnoli V, Clavenzani P, Azpiroz F, Stanghellini V, Sternini C, De Giorgio R. Enteric neuron density correlates with clinical features of severe gut dysmotility. Am J Physiol Gastrointest Liver Physiol. 2019 Dec 01; 317(6):G793-G801. PMID: 31545923.
      View in: PubMed
    2. Dothel G, Chang L, Shih W, Barbaro MR, Cremon C, Stanghellini V, De Ponti F, Mayer EA, Barbara G, Sternini C. µ-opioid receptor, ß-endorphin, and cannabinoid receptor-2 are increased in the colonic mucosa of irritable bowel syndrome patients. Neurogastroenterol Motil. 2019 11; 31(11):e13688. PMID: 31336406.
      View in: PubMed
    3. Boschetti E, Accarino A, Malagelada C, Malagelada JR, Cogliandro RF, Gori A, Tugnoli V, Giancola F, Bianco F, Bonora E, Clavenzani P, Volta U, Caio G, Sternini C, Stanghellini V, Azpiroz F, De Giorgio R. Gut epithelial and vascular barrier abnormalities in patients with chronic intestinal pseudo-obstruction. Neurogastroenterol Motil. 2019 08; 31(8):e13652. PMID: 31144425.
      View in: PubMed
    4. Galligan JJ, Sternini C. Insights into the Role of Opioid Receptors in the GI Tract: Experimental Evidence and Therapeutic Relevance. Handb Exp Pharmacol. 2017; 239:363-378. PMID: 28204957.
      View in: PubMed
    5. De Giorgio R, Mazzoni M, Vallorani C, Latorre R, Bombardi C, Bacci ML, Forni M, Falconi M, Sternini C, Clavenzani P. Correction: Regulation of a-Transducin and a-Gustducin Expression by a High Protein Diet in the Pig Gastrointestinal Tract. PLoS One. 2016; 11(3):e0152647. PMID: 27010316.
      View in: PubMed
    6. Bianco F, Bonora E, Natarajan D, Vargiolu M, Thapar N, Torresan F, Giancola F, Boschetti E, Volta U, Bazzoli F, Mazzoni M, Seri M, Clavenzani P, Stanghellini V, Sternini C, De Giorgio R. Prucalopride exerts neuroprotection in human enteric neurons. Am J Physiol Gastrointest Liver Physiol. 2016 05 15; 310(10):G768-75. PMID: 26893157.
      View in: PubMed
    7. De Giorgio R, Mazzoni M, Vallorani C, Latorre R, Bombardi C, Bacci ML, Forni M, Falconi M, Sternini C, Clavenzani P. Regulation of a-Transducin and a-Gustducin Expression by a High Protein Diet in the Pig Gastrointestinal Tract. PLoS One. 2016; 11(2):e0148954. PMID: 26871573.
      View in: PubMed
    8. Latorre R, Huynh J, Mazzoni M, Gupta A, Bonora E, Clavenzani P, Chang L, Mayer EA, De Giorgio R, Sternini C. Expression of the Bitter Taste Receptor, T2R38, in Enteroendocrine Cells of the Colonic Mucosa of Overweight/Obese vs. Lean Subjects. PLoS One. 2016; 11(2):e0147468. PMID: 26866366.
      View in: PubMed
    9. Duraffourd C, Kumala E, Anselmi L, Brecha NC, Sternini C. Opioid-induced mitogen-activated protein kinase signaling in rat enteric neurons following chronic morphine treatment. PLoS One. 2014; 9(10):e110230. PMID: 25302800.
      View in: PubMed
    10. Vegezzi G, Anselmi L, Huynh J, Barocelli E, Rozengurt E, Raybould H, Sternini C. Diet-induced regulation of bitter taste receptor subtypes in the mouse gastrointestinal tract. PLoS One. 2014; 9(9):e107732. PMID: 25238152.
      View in: PubMed
    11. Sternini C. In search of a role for carbonation: is this a good or bad taste? Gastroenterology. 2013 Sep; 145(3):500-3. PMID: 23891610.
      View in: PubMed
    12. Latorre R, Mazzoni M, De Giorgio R, Vallorani C, Bonaldo A, Gatta PP, Corinaldesi R, Ruggeri E, Bernardini C, Chiocchetti R, Sternini C, Clavenzani P. Enteroendocrine profile of a-transducin immunoreactive cells in the gastrointestinal tract of the European sea bass (Dicentrarchus labrax). Fish Physiol Biochem. 2013 Dec; 39(6):1555-65. PMID: 23748963.
      View in: PubMed
    13. Anselmi L, Jaramillo I, Palacios M, Huynh J, Sternini C. Ligand-induced µ opioid receptor internalization in enteric neurons following chronic treatment with the opiate fentanyl. J Neurosci Res. 2013 Jun; 91(6):854-60. PMID: 23553842.
      View in: PubMed
    14. Mazzoni M, De Giorgio R, Latorre R, Vallorani C, Bosi P, Trevisi P, Barbara G, Stanghellini V, Corinaldesi R, Forni M, Faussone-Pellegrini MS, Sternini C, Clavenzani P. Expression and regulation of a-transducin in the pig gastrointestinal tract. J Cell Mol Med. 2013 Apr; 17(4):466-74. PMID: 23414137.
      View in: PubMed
    15. Anselmi L, Huynh J, Vegezzi G, Sternini C. Effects of methylnaltrexone on guinea pig gastrointestinal motility. Naunyn Schmiedebergs Arch Pharmacol. 2013 Apr; 386(4):279-86. PMID: 23361094.
      View in: PubMed
    16. Saccani F, Anselmi L, Jaramillo I, Bertoni S, Barocelli E, Sternini C. Protective role of µ opioid receptor activation in intestinal inflammation induced by mesenteric ischemia/reperfusion in mice. J Neurosci Res. 2012 Nov; 90(11):2146-53. PMID: 22806643.
      View in: PubMed
    17. Patierno S, Anselmi L, Jaramillo I, Scott D, Garcia R, Sternini C. Morphine induces µ opioid receptor endocytosis in guinea pig enteric neurons following prolonged receptor activation. Gastroenterology. 2011 Feb; 140(2):618-26. PMID: 21070774.
      View in: PubMed
    18. Young SH, Rey O, Sternini C, Rozengurt E. Amino acid sensing by enteroendocrine STC-1 cells: role of the Na+-coupled neutral amino acid transporter 2. Am J Physiol Cell Physiol. 2010 Jun; 298(6):C1401-13. PMID: 20219951.
      View in: PubMed
    19. Anselmi L, Stella SL, Brecha NC, Sternini C. Galanin inhibition of voltage-dependent Ca(2+) influx in rat cultured myenteric neurons is mediated by galanin receptor 1. J Neurosci Res. 2009 Apr; 87(5):1107-14. PMID: 19006083.
      View in: PubMed
    20. Hao S, Dulake M, Espero E, Sternini C, Raybould HE, Rinaman L. Central Fos expression and conditioned flavor avoidance in rats following intragastric administration of bitter taste receptor ligands. Am J Physiol Regul Integr Comp Physiol. 2009 Mar; 296(3):R528-36. PMID: 19073908.
      View in: PubMed
    21. Sternini C, Anselmi L, Rozengurt E. Enteroendocrine cells: a site of 'taste' in gastrointestinal chemosensing. Curr Opin Endocrinol Diabetes Obes. 2008 Feb; 15(1):73-8. PMID: 18185066.
      View in: PubMed
    22. Rozengurt E, Sternini C. Taste receptor signaling in the mammalian gut. Curr Opin Pharmacol. 2007 Dec; 7(6):557-62. PMID: 18024184.
      View in: PubMed
    23. Hao S, Sternini C, Raybould HE. Role of CCK1 and Y2 receptors in activation of hindbrain neurons induced by intragastric administration of bitter taste receptor ligands. Am J Physiol Regul Integr Comp Physiol. 2008 Jan; 294(1):R33-8. PMID: 18003792.
      View in: PubMed
    24. Kimura T, Koya RC, Anselmi L, Sternini C, Wang HJ, Comin-Anduix B, Prins RM, Faure-Kumar E, Rozengurt N, Cui Y, Kasahara N, Stripecke R. Lentiviral vectors with CMV or MHCII promoters administered in vivo: immune reactivity versus persistence of expression. Mol Ther. 2007 Jul; 15(7):1390-9. PMID: 17505480.
      View in: PubMed
    25. Sternini C. Taste receptors in the gastrointestinal tract. IV. Functional implications of bitter taste receptors in gastrointestinal chemosensing. Am J Physiol Gastrointest Liver Physiol. 2007 Feb; 292(2):G457-61. PMID: 17095755.
      View in: PubMed
    26. Cattaruzza F, Cenac N, Barocelli E, Impicciatore M, Hyun E, Vergnolle N, Sternini C. Protective effect of proteinase-activated receptor 2 activation on motility impairment and tissue damage induced by intestinal ischemia/reperfusion in rodents. Am J Pathol. 2006 Jul; 169(1):177-88. PMID: 16816371.
      View in: PubMed
    27. Freeman SL, Glatzle J, Robin CS, Valdellon M, Sternini C, Sharp JW, Raybould HE. Ligand-induced 5-HT3 receptor internalization in enteric neurons in rat ileum. Gastroenterology. 2006 Jul; 131(1):97-107. PMID: 16831594.
      View in: PubMed
    28. Rozengurt N, Wu SV, Chen MC, Huang C, Sternini C, Rozengurt E. Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon. Am J Physiol Gastrointest Liver Physiol. 2006 Nov; 291(5):G792-802. PMID: 16728727.
      View in: PubMed
    29. Bradesi S, Kokkotou E, Simeonidis S, Patierno S, Ennes HS, Mittal Y, McRoberts JA, Ohning G, McLean P, Marvizon JC, Sternini C, Pothoulakis C, Mayer EA. The role of neurokinin 1 receptors in the maintenance of visceral hyperalgesia induced by repeated stress in rats. Gastroenterology. 2006 May; 130(6):1729-42. PMID: 16697737.
      View in: PubMed
    30. Tonini M, Vicini R, Cervio E, De Ponti F, De Giorgio R, Barbara G, Stanghellini V, Dellabianca A, Sternini C. 5-HT7 receptors modulate peristalsis and accommodation in the guinea pig ileum. Gastroenterology. 2005 Nov; 129(5):1557-66. PMID: 16285955.
      View in: PubMed
    31. Cottrell GS, Roosterman D, Marvizon JC, Song B, Wick E, Pikios S, Wong H, Berthelier C, Tang Y, Sternini C, Bunnett NW, Grady EF. Localization of calcitonin receptor-like receptor and receptor activity modifying protein 1 in enteric neurons, dorsal root ganglia, and the spinal cord of the rat. J Comp Neurol. 2005 Sep 26; 490(3):239-55. PMID: 16082677.
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    32. Anselmi L, Stella SL, Lakhter A, Hirano A, Tonini M, Sternini C. Galanin receptors in the rat gastrointestinal tract. Neuropeptides. 2005 Jun; 39(3):349-52. PMID: 16044511.
      View in: PubMed
    33. Patierno S, Zellalem W, Ho A, Parsons CG, Lloyd KC, Tonini M, Sternini C. N-methyl-D-aspartate receptors mediate endogenous opioid release in enteric neurons after abdominal surgery. Gastroenterology. 2005 Jun; 128(7):2009-19. PMID: 15940633.
      View in: PubMed
    34. Anselmi L, Lakhter A, Hirano AA, Tonini M, Sternini C. Expression of galanin receptor messenger RNAs in different regions of the rat gastrointestinal tract. Peptides. 2005 May; 26(5):815-9. PMID: 15808911.
      View in: PubMed
    35. Lu YC, Sternini C, Rozengurt E, Zhukova E. Release of transgenic human insulin from gastric g cells: a novel approach for the amelioration of diabetes. Endocrinology. 2005 Jun; 146(6):2610-9. PMID: 15731364.
      View in: PubMed
    36. Sternini C, Patierno S, Selmer IS, Kirchgessner A. The opioid system in the gastrointestinal tract. Neurogastroenterol Motil. 2004 Oct; 16 Suppl 2:3-16. PMID: 15357847.
      View in: PubMed
    37. Sternini C, Anselmi L, Guerrini S, Cervio E, Pham T, Balestra B, Vicini R, Baiardi P, D'agostino GL, Tonini M. Role of galanin receptor 1 in peristaltic activity in the guinea pig ileum. Neuroscience. 2004; 125(1):103-12. PMID: 15051149.
      View in: PubMed
    38. Ho A, Lievore A, Patierno S, Kohlmeier SE, Tonini M, Sternini C. Neurochemically distinct classes of myenteric neurons express the mu-opioid receptor in the guinea pig ileum. J Comp Neurol. 2003 Apr 14; 458(4):404-11. PMID: 12619074.
      View in: PubMed
    39. Raybould HE, Glatzle J, Robin C, Meyer JH, Phan T, Wong H, Sternini C. Expression of 5-HT3 receptors by extrinsic duodenal afferents contribute to intestinal inhibition of gastric emptying. Am J Physiol Gastrointest Liver Physiol. 2003 Mar; 284(3):G367-72. PMID: 12409280.
      View in: PubMed
    40. Pham T, Guerrini S, Wong H, Reeve J, Sternini C. Distribution of galanin receptor 1 immunoreactivity in the rat stomach and small intestine. J Comp Neurol. 2002 Aug 26; 450(3):292-302. PMID: 12209857.
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    41. Glatzle J, Sternini C, Robin C, Zittel TT, Wong H, Reeve JR, Raybould HE. Expression of 5-HT3 receptors in the rat gastrointestinal tract. Gastroenterology. 2002 Jul; 123(1):217-26. PMID: 12105850.
      View in: PubMed
    42. Salvioli B, Bovara M, Barbara G, De Ponti F, Stanghellini V, Tonini M, Guerrini S, Cremon C, Degli Esposti M, Koumandou M, Corinaldesi R, Sternini C, De Giorgio R. Neurology and neuropathology of the pancreatic innervation. JOP. 2002 Mar; 3(2):26-33. PMID: 11884764.
      View in: PubMed
    43. Sternini C. Receptors and transmission in the brain-gut axis: potential for novel therapies. III. Mu-opioid receptors in the enteric nervous system. Am J Physiol Gastrointest Liver Physiol. 2001 Jul; 281(1):G8-15. PMID: 11408250.
      View in: PubMed
    44. Sternini C, Brecha NC, Minnis J, D'Agostino G, Balestra B, Fiori E, Tonini M. Role of agonist-dependent receptor internalization in the regulation of mu opioid receptors. Neuroscience. 2000; 98(2):233-41. PMID: 10854754.
      View in: PubMed
    45. Sternini C, Wong H, Pham T, De Giorgio R, Miller LJ, Kuntz SM, Reeve JR, Walsh JH, Raybould HE. Expression of cholecystokinin A receptors in neurons innervating the rat stomach and intestine. Gastroenterology. 1999 Nov; 117(5):1136-46. PMID: 10535877.
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    46. Sternini C, Wong H, Wu SV, de Giorgio R, Yang M, Reeve J, Brecha NC, Walsh JH. Somatostatin 2A receptor is expressed by enteric neurons, and by interstitial cells of Cajal and enterochromaffin-like cells of the gastrointestinal tract. J Comp Neurol. 1997 Sep 29; 386(3):396-408. PMID: 9303425.
      View in: PubMed