Juan Enrique Rozengurt

Title(s)Professor, Medicine
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    Juan Enrique Rozengurt DVM, Ph.D., AGAF, holds the Ronald S. Hirshberg Chair in Translational Pancreatic Cancer Research.

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    Targeting YAP with statins to prevent antibody-mediated transplant rejection
    NIH R21AI156592Dec 18, 2020 - Nov 30, 2022
    Role: Co-Principal Investigator
    Identification of the growth-promoting PKD/YAP axis as a novel target for the statins in intestinal epithelial cells.
    NIH I01BX003801Jul 1, 2018 - Jun 30, 2022
    Role: Principal Investigator
    PKD1 Signaling and Crosstalk Mechanisms in Intestinal Epithelial Cell Regulation
    NIH R01DK100405Sep 1, 2014 - Jul 31, 2020
    Role: Principal Investigator
    Calcium-sensing receptor signaling in the regulation of colonic epithelial cells
    NIH I01BX001473Apr 1, 2012 - Mar 31, 2016
    Role: Principal Investigator
    Targeting crosstalk between insulin and Gq signaling systems in pancreatic cancer
    NIH R21CA137292May 1, 2009 - Apr 30, 2012
    Role: Principal Investigator
    The International Symposium on Regulatory Peptides
    NIH R13DK083177Sep 15, 2008 - Aug 31, 2009
    Role: Principal Investigator
    NIH R01DK056930Dec 1, 1999 - May 31, 2012
    Role: Principal Investigator
    Gastrointestinal Peptide Signaling through PKC/PKD
    NIH R01DK055003Mar 1, 1999 - May 31, 2014
    Role: Principal Investigator
    CURE: Digestive Diseases Research Center
    NIH P30DK041301Jan 15, 1990 - Nov 30, 2020
    Role: Principal Investigator
    NIH R01DK017294Feb 15, 1977 - Nov 30, 2004
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Suppression of feedback loops mediated by PI3K/mTOR induces multiple overactivation of compensatory pathways: an unintended consequence leading to drug resistance. Mol Cancer Ther. 2014 Nov; 13(11):2477-88. Rozengurt E, Soares HP, Sinnet-Smith J. PMID: 25323681; PMCID: PMC4222988.
      View in: PubMed   Mentions: 136     Fields:    Translation:HumansAnimalsCells
    2. Protein kinase D signaling: multiple biological functions in health and disease. Physiology (Bethesda). 2011 Feb; 26(1):23-33. Rozengurt E. PMID: 21357900; PMCID: PMC4381749.
      View in: PubMed   Mentions: 136     Fields:    Translation:HumansAnimalsCells
    3. Crosstalk between insulin/insulin-like growth factor-1 receptors and G protein-coupled receptor signaling systems: a novel target for the antidiabetic drug metformin in pancreatic cancer. Clin Cancer Res. 2010 May 01; 16(9):2505-11. Rozengurt E, Sinnett-Smith J, Kisfalvi K. PMID: 20388847; PMCID: PMC2862089.
      View in: PubMed   Mentions: 117     Fields:    Translation:HumansAnimalsCells
    4. Mitogenic signaling pathways induced by G protein-coupled receptors. J Cell Physiol. 2007 Dec; 213(3):589-602. Rozengurt E. PMID: 17786953.
      View in: PubMed   Mentions: 221     Fields:    Translation:HumansAnimalsCells
    5. Taste receptor signaling in the mammalian gut. Curr Opin Pharmacol. 2007 Dec; 7(6):557-62. Rozengurt E, Sternini C. PMID: 18024184; PMCID: PMC2753238.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    6. Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon. Am J Physiol Gastrointest Liver Physiol. 2006 Nov; 291(5):G792-802. Rozengurt N, Wu SV, Chen MC, Huang C, Sternini C, Rozengurt E. PMID: 16728727.
      View in: PubMed   Mentions: 111     Fields:    Translation:HumansCells
    7. Taste receptors in the gastrointestinal tract. I. Bitter taste receptors and alpha-gustducin in the mammalian gut. Am J Physiol Gastrointest Liver Physiol. 2006 Aug; 291(2):G171-7. Rozengurt E. PMID: 16710053.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    8. Protein kinase D signaling. J Biol Chem. 2005 Apr 08; 280(14):13205-8. Rozengurt E, Rey O, Waldron RT. PMID: 15701647.
      View in: PubMed   Mentions: 212     Fields:    Translation:HumansAnimalsCells
    9. Neuropeptides as growth factors for normal and cancerous cells. Trends Endocrinol Metab. 2002 Apr; 13(3):128-34. Rozengurt E. PMID: 11893527.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    10. Gastrointestinal peptide signalling in health and disease. Eur J Surg Suppl. 2002; (587):23-38. Rozengurt E, Guha S, Sinnett-Smith J. PMID: 16144198.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    11. Gastrin, CCK, signaling, and cancer. Annu Rev Physiol. 2001; 63:49-76. Rozengurt E, Walsh JH. PMID: 11181948.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    12. Changes in circulating lymphocytes induced by the administration of ACTH in cocks. Acta Physiol Lat Am. 1968; 18(1):82-7. Rozengurt JE, Fretz N, Capaul EG. PMID: 4298602.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    13. Changes in circulating lymphocytes induced by the administration of ACTH in cocks. Acta Physiol Lat Am. 1968; 18(1):74-9. Rozengurt JE, Fretz N, Capaul EG. PMID: 4298722.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
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