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Juan Enrique Rozengurt

Title(s)Professor, Medicine
SchoolMedicine
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    Collapse Overview 
    Collapse overview
    Juan Enrique Rozengurt DVM, Ph.D., AGAF, holds the Ronald S. Hirshberg Chair in Translational Pancreatic Cancer Research.

    Collapse Research 
    Collapse research activities and funding
    Targeting YAP with statins to prevent antibody-mediated transplant rejection
    NIH R21AI156592Dec 18, 2020 - Nov 30, 2022
    Role: Co-Principal Investigator
    Identification of the growth-promoting PKD/YAP axis as a novel target for the statins in intestinal epithelial cells.
    NIH I01BX003801Jul 1, 2018 - Jun 30, 2022
    Role: Principal Investigator
    PKD1 Signaling and Crosstalk Mechanisms in Intestinal Epithelial Cell Regulation
    NIH R01DK100405Sep 1, 2014 - Jul 31, 2020
    Role: Principal Investigator
    Calcium-sensing receptor signaling in the regulation of colonic epithelial cells
    NIH I01BX001473Apr 1, 2012 - Mar 31, 2016
    Role: Principal Investigator
    Targeting crosstalk between insulin and Gq signaling systems in pancreatic cancer
    NIH R21CA137292May 1, 2009 - Apr 30, 2012
    Role: Principal Investigator
    The International Symposium on Regulatory Peptides
    NIH R13DK083177Sep 15, 2008 - Aug 31, 2009
    Role: Principal Investigator
    GI PEPTIDE SIGNALING THROUGH TYROSINE PHOSPHORYLATION
    NIH R01DK056930Dec 1, 1999 - May 31, 2012
    Role: Principal Investigator
    Gastrointestinal Peptide Signaling through PKC/PKD
    NIH R01DK055003Mar 1, 1999 - May 31, 2014
    Role: Principal Investigator
    CURE: Digestive Diseases Research Center
    NIH P30DK041301Jan 15, 1990 - Nov 30, 2020
    Role: Principal Investigator
    HORMONAL STIMULATION &INHIBITION OF GASTRIC SECRETION
    NIH R01DK017294Feb 15, 1977 - Nov 30, 2004
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Protein Kinase D1 (PKD1) Signaling Induces Growth-Promoting Effects in Murine Enteroids. Cell Mol Gastroenterol Hepatol. 2020; 10(2):430-433.e9. Shimizu Y, Sinnett-Smith J, Tenggara M, Martin MG, Rozengurt E. PMID: 32234448; PMCID: PMC7371955.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    2. Protein kinase D1 (PKD1) phosphorylation on Ser203 by type I p21-activated kinase (PAK) regulates PKD1 localization. J Biol Chem. 2017 06 09; 292(23):9523-9539. Chang JK, Ni Y, Han L, Sinnett-Smith J, Jacamo R, Rey O, Young SH, Rozengurt E. PMID: 28408623; PMCID: PMC5465480.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    3. Insulin Receptor and GPCR Crosstalk Stimulates YAP via PI3K and PKD in Pancreatic Cancer Cells. Mol Cancer Res. 2017 07; 15(7):929-941. Hao F, Xu Q, Zhao Y, Stevens JV, Young SH, Sinnett-Smith J, Rozengurt E. PMID: 28360038; PMCID: PMC5645013.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    4. Biphasic Regulation of Yes-associated Protein (YAP) Cellular Localization, Phosphorylation, and Activity by G Protein-coupled Receptor Agonists in Intestinal Epithelial Cells: A NOVEL ROLE FOR PROTEIN KINASE D (PKD). J Biol Chem. 2016 08 19; 291(34):17988-8005. Wang J, Sinnett-Smith J, Stevens JV, Young SH, Rozengurt E. PMID: 27369082; PMCID: PMC5016186.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    5. Positive cross talk between protein kinase D and β-catenin in intestinal epithelial cells: impact on β-catenin nuclear localization and phosphorylation at Ser552. Am J Physiol Cell Physiol. 2016 Apr 01; 310(7):C542-57. Wang J, Han L, Sinnett-Smith J, Han LL, Stevens JV, Rozengurt N, Young SH, Rozengurt E. PMID: 26739494; PMCID: PMC4824155.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    6. Intracellular Ca(2+) oscillations generated via the extracellular Ca(2+)-sensing receptor (CaSR) in response to extracellular Ca(2+) or L-phenylalanine: Impact of the highly conservative mutation Ser170Thr. Biochem Biophys Res Commun. 2015 Nov 06; 467(1):1-6. Young SH, Rey O, Rozengurt E. PMID: 26431875; PMCID: PMC4613767.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    7. Dual PI3K/mTOR Inhibitors Induce Rapid Overactivation of the MEK/ERK Pathway in Human Pancreatic Cancer Cells through Suppression of mTORC2. Mol Cancer Ther. 2015 Apr; 14(4):1014-23. Soares HP, Ming M, Mellon M, Young SH, Han L, Sinnet-Smith J, Rozengurt E. PMID: 25673820; PMCID: PMC4394038.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    8. Suppression of feedback loops mediated by PI3K/mTOR induces multiple overactivation of compensatory pathways: an unintended consequence leading to drug resistance. Mol Cancer Ther. 2014 Nov; 13(11):2477-88. Rozengurt E, Soares HP, Sinnet-Smith J. PMID: 25323681; PMCID: PMC4222988.
      View in: PubMed   Mentions: 163     Fields:    Translation:HumansAnimalsCells
    9. Protein kinase D1 mediates class IIa histone deacetylase phosphorylation and nuclear extrusion in intestinal epithelial cells: role in mitogenic signaling. Am J Physiol Cell Physiol. 2014 May 15; 306(10):C961-71. Sinnett-Smith J, Ni Y, Wang J, Ming M, Young SH, Rozengurt E. PMID: 24647541; PMCID: PMC4024715.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    10. Protein kinase D signaling: multiple biological functions in health and disease. Physiology (Bethesda). 2011 Feb; 26(1):23-33. Rozengurt E. PMID: 21357900; PMCID: PMC4381749.
      View in: PubMed   Mentions: 148     Fields:    Translation:HumansAnimalsCells
    11. Crosstalk between insulin/insulin-like growth factor-1 receptors and G protein-coupled receptor signaling systems: a novel target for the antidiabetic drug metformin in pancreatic cancer. Clin Cancer Res. 2010 May 01; 16(9):2505-11. Rozengurt E, Sinnett-Smith J, Kisfalvi K. PMID: 20388847; PMCID: PMC2862089.
      View in: PubMed   Mentions: 128     Fields:    Translation:HumansAnimalsCells
    12. Protein kinase D mediates mitogenic signaling by Gq-coupled receptors through protein kinase C-independent regulation of activation loop Ser744 and Ser748 phosphorylation. J Biol Chem. 2009 May 15; 284(20):13434-13445. Sinnett-Smith J, Jacamo R, Kui R, Wang YM, Young SH, Rey O, Waldron RT, Rozengurt E. PMID: 19289471; PMCID: PMC2679443.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    13. Mitogenic signaling pathways induced by G protein-coupled receptors. J Cell Physiol. 2007 Dec; 213(3):589-602. Rozengurt E. PMID: 17786953.
      View in: PubMed   Mentions: 227     Fields:    Translation:HumansAnimalsCells
    14. Taste receptor signaling in the mammalian gut. Curr Opin Pharmacol. 2007 Dec; 7(6):557-62. Rozengurt E, Sternini C. PMID: 18024184; PMCID: PMC2753238.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    15. Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon. Am J Physiol Gastrointest Liver Physiol. 2006 Nov; 291(5):G792-802. Rozengurt N, Wu SV, Chen MC, Huang C, Sternini C, Rozengurt E. PMID: 16728727.
      View in: PubMed   Mentions: 117     Fields:    Translation:HumansCells
    16. Taste receptors in the gastrointestinal tract. I. Bitter taste receptors and alpha-gustducin in the mammalian gut. Am J Physiol Gastrointest Liver Physiol. 2006 Aug; 291(2):G171-7. Rozengurt E. PMID: 16710053.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimalsCells
    17. Protein kinase D signaling. J Biol Chem. 2005 Apr 08; 280(14):13205-8. Rozengurt E, Rey O, Waldron RT. PMID: 15701647.
      View in: PubMed   Mentions: 220     Fields:    Translation:HumansAnimalsCells
    18. Neuropeptides as growth factors for normal and cancerous cells. Trends Endocrinol Metab. 2002 Apr; 13(3):128-34. Rozengurt E. PMID: 11893527.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    19. Gastrointestinal peptide signalling in health and disease. Eur J Surg Suppl. 2002; (587):23-38. Rozengurt E, Guha S, Sinnett-Smith J. PMID: 16144198.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    20. Gastrin, CCK, signaling, and cancer. Annu Rev Physiol. 2001; 63:49-76. Rozengurt E, Walsh JH. PMID: 11181948.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    21. Changes in circulating lymphocytes induced by the administration of ACTH in cocks. Acta Physiol Lat Am. 1968; 18(1):82-7. Rozengurt JE, Fretz N, Capaul EG. PMID: 4298602.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    22. Changes in circulating lymphocytes induced by the administration of ACTH in cocks. Acta Physiol Lat Am. 1968; 18(1):74-9. Rozengurt JE, Fretz N, Capaul EG. PMID: 4298722.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
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