Rhonda Renee Voskuhl

Title(s)Professor-in-Residence, Neurology
SchoolMedicine
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    Dr. Rhonda R. Voskuhl holds the Jack H. Skirball Chair for Multiple Sclerosis Research.

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    Neuroprotection in MS: A Cell-Specific and Region-Specific Transcriptomics Approach
    NIH R01NS109670Sep 30, 2018 - May 31, 2023
    Role: Principal Investigator
    Parental imprinting of the X chromosome: effects on neurodegeneration
    NIH R01NS096748Sep 1, 2016 - Jun 30, 2021
    Role: Principal Investigator
    Sex differences in the CNS during disease
    NIH R21NS071210Jun 1, 2010 - May 31, 2013
    Role: Principal Investigator
    Treatment of Multiple Sclerosis with Sex Hormones
    NIH K24NS062117Apr 1, 2008 - Mar 31, 2013
    Role: Principal Investigator
    Sex Chromosome Effects in Lupus
    NIH R21AI070306Mar 1, 2007 - Feb 28, 2009
    Role: Principal Investigator
    A Combination Trial of Copaxone plus Estriol in RRMS
    NIH R01NS051591Apr 1, 2005 - Apr 30, 2014
    Role: Principal Investigator
    Protective Effect of Pregnancy Doses of Estrogens in EAE
    NIH R01NS045443Aug 15, 2002 - Jul 31, 2006
    Role: Principal Investigator
    The Effect of Sex Chromosomes on Immune Responses
    NIH R01AI050839Feb 1, 2002 - Jan 31, 2010
    Role: Principal Investigator
    IMMUNE MECHANISMS UNDERLYING GENDER DIFFERENCES IN EAE
    NIH R01NS036680Aug 1, 1997 - May 31, 2001
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Sex differences in the neuronal transcriptome and synaptic mitochondrial function in the cerebral cortex of a multiple sclerosis model. Front Neurol. 2023; 14:1268411. Itoh N, Itoh Y, Stiles L, Voskuhl R. PMID: 38020654; PMCID: PMC10654219.
      View in: PubMed   Mentions:
    2. Estrogen receptor beta in astrocytes modulates cognitive function in mid-age female mice. Nat Commun. 2023 09 28; 14(1):6044. Itoh N, Itoh Y, Meyer CE, Suen TT, Cortez-Delgado D, Rivera Lomeli M, Wendin S, Somepalli SS, Golden LC, MacKenzie-Graham A, Voskuhl RR. PMID: 37758709; PMCID: PMC10533869.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    3. Neuroprotection in Cerebral Cortex Induced by the Pregnancy Hormone Estriol. Lab Invest. 2023 08; 103(8):100189. Meyer CE, Smith AW, Padilla-Requerey AA, Farkhondeh V, Itoh N, Itoh Y, Gao JL, Herbig PD, Nguyen Q, Ngo KH, Oberoi MR, Siddarth P, Voskuhl RR, MacKenzie-Graham A. PMID: 37245852.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    4. The X factor in neurodegeneration. J Exp Med. 2022 12 05; 219(12). Voskuhl R, Itoh Y. PMID: 36331399; PMCID: PMC9641640.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    5. Chronic experimental autoimmune encephalomyelitis is an excellent model to study neuroaxonal degeneration in multiple sclerosis. Front Mol Neurosci. 2022; 15:1024058. Voskuhl RR, MacKenzie-Graham A. PMID: 36340686; PMCID: PMC9629273.
      View in: PubMed   Mentions: 6  
    6. Decreased neurofilament light chain levels in estriol-treated multiple sclerosis. Ann Clin Transl Neurol. 2022 08; 9(8):1316-1320. Voskuhl R, Kuhle J, Siddarth P, Itoh N, Patel K, MacKenzie-Graham A. PMID: 35770318; PMCID: PMC9380170.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    7. B-Cell Depletion and COVID-19 Severity in Multiple Sclerosis: Remaining Challenges. Neurology. 2021 11 09; 97(19):885-886. Killestein J, Schoonheim MM, Voskuhl RR. PMID: 34610986.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    8. A new cell subtype that confers neuroprotection. Nat Immunol. 2020 12; 21(12):1477-1478. Voskuhl R. PMID: 33139916.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    9. Sex differences in brain atrophy in multiple sclerosis. Biol Sex Differ. 2020 08 28; 11(1):49. Voskuhl RR, Patel K, Paul F, Gold SM, Scheel M, Kuchling J, Cooper G, Asseyer S, Chien C, Brandt AU, Meyer CE, MacKenzie-Graham A. PMID: 32859258; PMCID: PMC7456053.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    10. Sex effects across the lifespan in women with multiple sclerosis. Ther Adv Neurol Disord. 2020; 13:1756286420936166. Krysko KM, Graves JS, Dobson R, Altintas A, Amato MP, Bernard J, Bonavita S, Bove R, Cavalla P, Clerico M, Corona T, Doshi A, Fragoso Y, Jacobs D, Jokubaitis V, Landi D, Llamosa G, Longbrake EE, Maillart E, Marta M, Midaglia L, Shah S, Tintore M, van der Walt A, Voskuhl R, Wang Y, Zabad RK, Zeydan B, Houtchens M, Hellwig K. PMID: 32655689; PMCID: PMC7331774.
      View in: PubMed   Mentions: 27  
    11. The effect of sex on multiple sclerosis risk and disease progression. Mult Scler. 2020 04; 26(5):554-560. Voskuhl RR. PMID: 31965884; PMCID: PMC7160019.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    12. Parent-of-origin differences in DNA methylation of X chromosome genes in T lymphocytes. Proc Natl Acad Sci U S A. 2019 Dec 26; 116(52):26779-26787. Golden LC, Itoh Y, Itoh N, Iyengar S, Coit P, Salama Y, Arnold AP, Sawalha AH, Voskuhl RR. PMID: 31822606; PMCID: PMC6936674.
      View in: PubMed   Mentions: 37     Fields:    
    13. The X-linked histone demethylase Kdm6a in CD4+ T lymphocytes modulates autoimmunity. J Clin Invest. 2019 08 12; 129(9):3852-3863. Itoh Y, Golden LC, Itoh N, Matsukawa MA, Ren E, Tse V, Arnold AP, Voskuhl RR. PMID: 31403472; PMCID: PMC6715385.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    14. The astrocyte transcriptome in EAE optic neuritis shows complement activation and reveals a sex difference in astrocytic C3 expression. Sci Rep. 2019 07 10; 9(1):10010. Tassoni A, Farkhondeh V, Itoh Y, Itoh N, Sofroniew MV, Voskuhl RR. PMID: 31292459; PMCID: PMC6620300.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    15. Gene expression in oligodendrocytes during remyelination reveals cholesterol homeostasis as a therapeutic target in multiple sclerosis. Proc Natl Acad Sci U S A. 2019 05 14; 116(20):10130-10139. Voskuhl RR, Itoh N, Tassoni A, Matsukawa MA, Ren E, Tse V, Jang E, Suen TT, Itoh Y. PMID: 31040210; PMCID: PMC6525478.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    16. Sex is a biological variable - in the brain too. Nature. 2019 04; 568(7751):171. Voskuhl R, Klein S. PMID: 30967673.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    17. Axonal damage in spinal cord is associated with gray matter atrophy in sensorimotor cortex in experimental autoimmune encephalomyelitis. Mult Scler. 2020 03; 26(3):294-303. Meyer CE, Gao JL, Cheng JY, Oberoi MR, Johnsonbaugh H, Lepore S, Kurth F, Thurston MJ, Itoh N, Patel KR, Voskuhl RR, MacKenzie-Graham A. PMID: 30843756; PMCID: PMC6957766.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    18. Enhanced GABAergic Tonic Inhibition Reduces Intrinsic Excitability of Hippocampal CA1 Pyramidal Cells in Experimental Autoimmune Encephalomyelitis. Neuroscience. 2018 12 15; 395:89-100. Kammel LG, Wei W, Jami SA, Voskuhl RR, O'Dell TJ. PMID: 30447391; PMCID: PMC6289277.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    19. Estriol-mediated neuroprotection in multiple sclerosis localized by voxel-based morphometry. Brain Behav. 2018 09; 8(9):e01086. MacKenzie-Graham A, Brook J, Kurth F, Itoh Y, Meyer C, Montag MJ, Wang HJ, Elashoff R, Voskuhl RR. PMID: 30144306; PMCID: PMC6160650.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    20. It is time to conduct phase 3 clinical trials of sex hormones in MS - Yes. Mult Scler. 2018 10; 24(11):1413-1415. Voskuhl R. PMID: 30058469; PMCID: PMC6173646.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    21. Oestrogen receptor β ligand acts on CD11c+ cells to mediate protection in experimental autoimmune encephalomyelitis. Brain. 2018 01 01; 141(1):132-147. Kim RY, Mangu D, Hoffman AS, Kavosh R, Jung E, Itoh N, Voskuhl R. PMID: 29228214; PMCID: PMC5837360.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    22. Sex chromosome contributions to sex differences in multiple sclerosis susceptibility and progression. Mult Scler. 2018 01; 24(1):22-31. Voskuhl RR, Sawalha AH, Itoh Y. PMID: 29307297; PMCID: PMC5823689.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    23. Cell-specific and region-specific transcriptomics in the multiple sclerosis model: Focus on astrocytes. Proc Natl Acad Sci U S A. 2018 01 09; 115(2):E302-E309. Itoh N, Itoh Y, Tassoni A, Ren E, Kaito M, Ohno A, Ao Y, Farkhondeh V, Johnsonbaugh H, Burda J, Sofroniew MV, Voskuhl RR. PMID: 29279367; PMCID: PMC5777065.
      View in: PubMed   Mentions: 127     Fields:    Translation:AnimalsCells
    24. Pregnancy: Effect on Multiple Sclerosis, Treatment Considerations, and Breastfeeding. Neurotherapeutics. 2017 Oct; 14(4):974-984. Voskuhl R, Momtazee C. PMID: 28766273; PMCID: PMC5722767.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    25. Cell specificity dictates similarities in gene expression in multiple sclerosis, Parkinson's disease, and Alzheimer's disease. PLoS One. 2017; 12(7):e0181349. Itoh Y, Voskuhl RR. PMID: 28715462; PMCID: PMC5513529.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    26. Speaking out about gender imbalance in invited speakers improves diversity. Nat Immunol. 2017 04 18; 18(5):475-478. Klein RS, Voskuhl R, Segal BM, Dittel BN, Lane TE, Bethea JR, Carson MJ, Colton C, Rosi S, Anderson A, Piccio L, Goverman JM, Benveniste EN, Brown MA, Tiwari-Woodruff SK, Harris TH, Cross AH. PMID: 28418385; PMCID: PMC5775963.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    27. The importance of studying sex differences in disease: The example of multiple sclerosis. J Neurosci Res. 2017 01 02; 95(1-2):633-643. Golden LC, Voskuhl R. PMID: 27870415; PMCID: PMC5825192.
      View in: PubMed   Mentions: 53     Fields:    Translation:Humans
    28. Bedside to bench to bedside research: Estrogen receptor beta ligand as a candidate neuroprotective treatment for multiple sclerosis. J Neuroimmunol. 2017 03 15; 304:63-71. Itoh N, Kim R, Peng M, DiFilippo E, Johnsonbaugh H, MacKenzie-Graham A, Voskuhl RR. PMID: 27771018; PMCID: PMC5806698.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    29. Hormone replacement in menopausal women with multiple sclerosis: Looking back, thinking forward. Neurology. 2016 10 04; 87(14):1430-1431. Voskuhl R, Patti F. PMID: 27605172.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    30. Pregnancy and multiple sclerosis: from molecular mechanisms to clinical application. Semin Immunopathol. 2016 11; 38(6):709-718. Gold SM, Voskuhl RR. PMID: 27501960.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    31. Disability-Specific Atlases of Gray Matter Loss in Relapsing-Remitting Multiple Sclerosis. JAMA Neurol. 2016 Aug 01; 73(8):944-53. MacKenzie-Graham A, Kurth F, Itoh Y, Wang HJ, Montag MJ, Elashoff R, Voskuhl RR. PMID: 27294295; PMCID: PMC6415681.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCTClinical Trials
    32. Rebound Relapses After Ceasing Another Disease-Modifying Treatment in Patients With Multiple Sclerosis: Are There Lessons to Be Learned? JAMA Neurol. 2016 07 01; 73(7):775-6. Voskuhl R. PMID: 27136400.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    33. Why use sex hormones in relapsing-remitting multiple sclerosis? - Authors' reply. Lancet Neurol. 2016 07; 15(8):790-791. Voskuhl R, Wang H, Elashoff RM. PMID: 27302354.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    34. Preclinical studies of sex differences: a clinical perspective. Biol Sex Differ. 2016; 7:7. Voskuhl R. PMID: 26807212; PMCID: PMC4722789.
      View in: PubMed   Mentions: 6     Fields:    
    35. Estriol combined with glatiramer acetate for women with relapsing-remitting multiple sclerosis: a randomised, placebo-controlled, phase 2 trial. Lancet Neurol. 2016 Jan; 15(1):35-46. Voskuhl RR, Wang H, Wu TC, Sicotte NL, Nakamura K, Kurth F, Itoh N, Bardens J, Bernard JT, Corboy JR, Cross AH, Dhib-Jalbut S, Ford CC, Frohman EM, Giesser B, Jacobs D, Kasper LH, Lynch S, Parry G, Racke MK, Reder AT, Rose J, Wingerchuk DM, MacKenzie-Graham AJ, Arnold DL, Tseng CH, Elashoff R. PMID: 26621682.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansCTClinical Trials
    36. Astrocyte CCL2 sustains immune cell infiltration in chronic experimental autoimmune encephalomyelitis. J Neuroimmunol. 2014 Sep 15; 274(1-2):53-61. Kim RY, Hoffman AS, Itoh N, Ao Y, Spence R, Sofroniew MV, Voskuhl RR. PMID: 25005117; PMCID: PMC4343306.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    37. Neuroprotective effects of testosterone treatment in men with multiple sclerosis. Neuroimage Clin. 2014; 4:454-60. Kurth F, Luders E, Sicotte NL, Gaser C, Giesser BS, Swerdloff RS, Montag MJ, Voskuhl RR, Mackenzie-Graham A. PMID: 24634831; PMCID: PMC3952353.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCTClinical Trials
    38. XY sex chromosome complement, compared with XX, in the CNS confers greater neurodegeneration during experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2014 Feb 18; 111(7):2806-11. Du S, Itoh N, Askarinam S, Hill H, Arnold AP, Voskuhl RR. PMID: 24550311; PMCID: PMC3932937.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    39. The androgen receptor as a therapeutic target for myelin repair in demyelinating diseases. Expert Rev Endocrinol Metab. 2014 Jan; 9(1):5-7. Ghandour S, Voskuhl R, Schumacher M. PMID: 30743734.
      View in: PubMed   Mentions:    Fields:    
    40. Estrogen mediates neuroprotection and anti-inflammatory effects during EAE through ERα signaling on astrocytes but not through ERβ signaling on astrocytes or neurons. J Neurosci. 2013 Jun 26; 33(26):10924-33. Spence RD, Wisdom AJ, Cao Y, Hill HM, Mongerson CR, Stapornkul B, Itoh N, Sofroniew MV, Voskuhl RR. PMID: 23804112; PMCID: PMC3693061.
      View in: PubMed   Mentions: 83     Fields:    Translation:AnimalsCells
    41. Estrogen receptor-β ligand treatment after disease onset is neuroprotective in the multiple sclerosis model. J Neurosci Res. 2013 Jul; 91(7):901-8. Wisdom AJ, Cao Y, Itoh N, Spence RD, Voskuhl RR. PMID: 23633287; PMCID: PMC4376676.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    42. Assisted reproduction technology in multiple sclerosis: giving birth to a new avenue of research in hormones and autoimmunity. Ann Neurol. 2012 Nov; 72(5):631-2. Voskuhl RR. PMID: 23280787.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    43. Therapeutic testosterone administration preserves excitatory synaptic transmission in the hippocampus during autoimmune demyelinating disease. J Neurosci. 2012 Sep 05; 32(36):12312-24. Ziehn MO, Avedisian AA, Dervin SM, Umeda EA, O'Dell TJ, Voskuhl RR. PMID: 22956822; PMCID: PMC3571760.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    44. Dynamic development of glucocorticoid resistance during autoimmune neuroinflammation. J Clin Endocrinol Metab. 2012 Aug; 97(8):E1402-10. Gold SM, Sasidhar MV, Lagishetty V, Spence RD, Umeda E, Ziehn MO, Krieger T, Schulz KH, Heesen C, Hewison M, Voskuhl RR. PMID: 22659246; PMCID: PMC3410265.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    45. The XX sex chromosome complement in mice is associated with increased spontaneous lupus compared with XY. Ann Rheum Dis. 2012 Aug; 71(8):1418-22. Sasidhar MV, Itoh N, Gold SM, Lawson GW, Voskuhl RR. PMID: 22580585; PMCID: PMC4452281.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    46. Estriol preserves synaptic transmission in the hippocampus during autoimmune demyelinating disease. Lab Invest. 2012 Aug; 92(8):1234-45. Ziehn MO, Avedisian AA, Dervin SM, O'Dell TJ, Voskuhl RR. PMID: 22525427; PMCID: PMC4343001.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    47. Sex-related factors in multiple sclerosis susceptibility and progression. Nat Rev Neurol. 2012 Mar 27; 8(5):255-63. Voskuhl RR, Gold SM. PMID: 22450508; PMCID: PMC4435786.
      View in: PubMed   Mentions: 104     Fields:    Translation:Humans
    48. Estrogen treatment prevents gray matter atrophy in experimental autoimmune encephalomyelitis. J Neurosci Res. 2012 Jul; 90(7):1310-23. MacKenzie-Graham AJ, Rinek GA, Avedisian A, Morales LB, Umeda E, Boulat B, Jacobs RE, Toga AW, Voskuhl RR. PMID: 22411609; PMCID: PMC3350614.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    49. Pregnancy: a "modifiable" risk factor in MS? Neurology. 2012 Mar 20; 78(12):846-8. Daumer M, Weinshenker BG, Voskuhl R. PMID: 22402865.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    50. Neuroprotective effects of estrogens and androgens in CNS inflammation and neurodegeneration. Front Neuroendocrinol. 2012 Jan; 33(1):105-15. Spence RD, Voskuhl RR. PMID: 22209870; PMCID: PMC3616506.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansAnimals
    51. Cortical atrophy in experimental autoimmune encephalomyelitis: in vivo imaging. Neuroimage. 2012 Mar; 60(1):95-104. MacKenzie-Graham A, Rinek GA, Avedisian A, Gold SM, Frew AJ, Aguilar C, Lin DR, Umeda E, Voskuhl RR, Alger JR. PMID: 22182769; PMCID: PMC3293104.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    52. Neuroprotection mediated through estrogen receptor-alpha in astrocytes. Proc Natl Acad Sci U S A. 2011 May 24; 108(21):8867-72. Spence RD, Hamby ME, Umeda E, Itoh N, Du S, Wisdom AJ, Cao Y, Bondar G, Lam J, Ao Y, Sandoval F, Suriany S, Sofroniew MV, Voskuhl RR. PMID: 21555578; PMCID: PMC3102368.
      View in: PubMed   Mentions: 109     Fields:    Translation:AnimalsCells
    53. Sex differences in autoimmune diseases. Biol Sex Differ. 2011 Jan 04; 2(1):1. Voskuhl R. PMID: 21208397; PMCID: PMC3022636.
      View in: PubMed   Mentions: 108     Fields:    
    54. Estrogen receptor-β ligand treatment modulates dendritic cells in the target organ during autoimmune demyelinating disease. Eur J Immunol. 2011 Jan; 41(1):140-50. Du S, Sandoval F, Trinh P, Umeda E, Voskuhl R. PMID: 21182085; PMCID: PMC3042725.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    55. An animal model of cortical and callosal pathology in multiple sclerosis. Brain Pathol. 2011 May; 21(3):263-78. Mangiardi M, Crawford DK, Xia X, Du S, Simon-Freeman R, Voskuhl RR, Tiwari-Woodruff SK. PMID: 21029240; PMCID: PMC5233755.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    56. Oestrogen receptor beta ligand: a novel treatment to enhance endogenous functional remyelination. Brain. 2010 Oct; 133(10):2999-3016. Crawford DK, Mangiardi M, Song B, Patel R, Du S, Sofroniew MV, Voskuhl RR, Tiwari-Woodruff SK. PMID: 20858739; PMCID: PMC2947430.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    57. Hippocampal CA1 atrophy and synaptic loss during experimental autoimmune encephalomyelitis, EAE. Lab Invest. 2010 May; 90(5):774-86. Ziehn MO, Avedisian AA, Tiwari-Woodruff S, Voskuhl RR. PMID: 20157291; PMCID: PMC3033772.
      View in: PubMed   Mentions: 101     Fields:    Translation:AnimalsCells
    58. Additive effects of combination treatment with anti-inflammatory and neuroprotective agents in experimental autoimmune encephalomyelitis. J Neuroimmunol. 2010 Feb 26; 219(1-2):64-74. Du S, Sandoval F, Trinh P, Voskuhl RR. PMID: 20006910; PMCID: PMC3037186.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    59. Reactive astrocytes form scar-like perivascular barriers to leukocytes during adaptive immune inflammation of the CNS. J Neurosci. 2009 Sep 16; 29(37):11511-22. Voskuhl RR, Peterson RS, Song B, Ao Y, Morales LB, Tiwari-Woodruff S, Sofroniew MV. PMID: 19759299; PMCID: PMC2768309.
      View in: PubMed   Mentions: 228     Fields:    Translation:AnimalsCells
    60. Estrogen treatment decreases matrix metalloproteinase (MMP)-9 in autoimmune demyelinating disease through estrogen receptor alpha (ERalpha). Lab Invest. 2009 Oct; 89(10):1076-83. Gold SM, Sasidhar MV, Morales LB, Du S, Sicotte NL, Tiwari-Woodruff SK, Voskuhl RR. PMID: 19668239; PMCID: PMC2753699.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    61. Purkinje cell loss in experimental autoimmune encephalomyelitis. Neuroimage. 2009 Dec; 48(4):637-51. MacKenzie-Graham A, Tiwari-Woodruff SK, Sharma G, Aguilar C, Vo KT, Strickland LV, Morales L, Fubara B, Martin M, Jacobs RE, Johnson GA, Toga AW, Voskuhl RR. PMID: 19589388; PMCID: PMC2754586.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    62. Estrogen treatment in multiple sclerosis. J Neurol Sci. 2009 Nov 15; 286(1-2):99-103. Gold SM, Voskuhl RR. PMID: 19539954; PMCID: PMC2760629.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimals
    63. Neuroprotective and anti-inflammatory effects of estrogen receptor ligand treatment in mice. J Neurol Sci. 2009 Nov 15; 286(1-2):81-5. Tiwari-Woodruff S, Voskuhl RR. PMID: 19442988; PMCID: PMC2760614.
      View in: PubMed   Mentions: 33     Fields:    Translation:Animals
    64. Estrogen and testosterone therapies in multiple sclerosis. Prog Brain Res. 2009; 175:239-51. Gold SM, Voskuhl RR. PMID: 19660660; PMCID: PMC2724009.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimals
    65. Do estroprogestinic hormones protect against chemotherapy-induced amenorrhea in multiple sclerosis? Nat Clin Pract Neurol. 2009 Jan; 5(1):18-9. Voskuhl R, Wu TC. PMID: 19030003; PMCID: PMC2670893.
      View in: PubMed   Mentions:    Fields:    
    66. Immune modulation and increased neurotrophic factor production in multiple sclerosis patients treated with testosterone. J Neuroinflammation. 2008 Jul 31; 5:32. Gold SM, Chalifoux S, Giesser BS, Voskuhl RR. PMID: 18671877; PMCID: PMC2518142.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    67. Glial reactions and degeneration of myelinated processes in spinal cord gray matter in chronic experimental autoimmune encephalomyelitis. Neuroscience. 2008 Oct 15; 156(3):586-96. Wu J, Ohlsson M, Warner EA, Loo KK, Hoang TX, Voskuhl RR, Havton LA. PMID: 18718511; PMCID: PMC2670892.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    68. A role for sex chromosome complement in the female bias in autoimmune disease. J Exp Med. 2008 May 12; 205(5):1099-108. Smith-Bouvier DL, Divekar AA, Sasidhar M, Du S, Tiwari-Woodruff SK, King JK, Arnold AP, Singh RR, Voskuhl RR. PMID: 18443225; PMCID: PMC2373842.
      View in: PubMed   Mentions: 180     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    69. Differential neuroprotective and antiinflammatory effects of estrogen receptor (ER)alpha and ERbeta ligand treatment. Proc Natl Acad Sci U S A. 2007 Sep 11; 104(37):14813-8. Tiwari-Woodruff S, Morales LB, Lee R, Voskuhl RR. PMID: 17785421; PMCID: PMC1976208.
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    70. Testosterone treatment in multiple sclerosis: a pilot study. Arch Neurol. 2007 May; 64(5):683-8. Sicotte NL, Giesser BS, Tandon V, Klutch R, Steiner B, Drain AE, Shattuck DW, Hull L, Wang HJ, Elashoff RM, Swerdloff RS, Voskuhl RR. PMID: 17502467.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansCTClinical Trials
    71. A female preponderance for chemically induced lupus in SJL/J mice. Clin Immunol. 2007 Jan; 122(1):101-7. Smith DL, Dong X, Du S, Oh M, Singh RR, Voskuhl RR. PMID: 17084107; PMCID: PMC2291542.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    72. Testosterone replacement therapy for the treatment of neurological and neuropsychiatric disorders. Curr Opin Investig Drugs. 2006 Jul; 7(7):625-30. Gold SM, Voskuhl RR. PMID: 16869115.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    73. Cerebellar cortical atrophy in experimental autoimmune encephalomyelitis. Neuroimage. 2006 Sep; 32(3):1016-23. MacKenzie-Graham A, Tinsley MR, Shah KP, Aguilar C, Strickland LV, Boline J, Martin M, Morales L, Shattuck DW, Jacobs RE, Voskuhl RR, Toga AW. PMID: 16806982.
      View in: PubMed   Mentions: 33     Fields:    Translation:Animals
    74. Treatment with an estrogen receptor alpha ligand is neuroprotective in experimental autoimmune encephalomyelitis. J Neurosci. 2006 Jun 21; 26(25):6823-33. Morales LB, Loo KK, Liu HB, Peterson C, Tiwari-Woodruff S, Voskuhl RR. PMID: 16793889; PMCID: PMC6673842.
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    75. A yin-yang effect between sex chromosome complement and sex hormones on the immune response. Endocrinology. 2005 Aug; 146(8):3280-5. Palaszynski KM, Smith DL, Kamrava S, Burgoyne PS, Arnold AP, Voskuhl RR. PMID: 15905317.
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    76. Method to detect functional estrogen receptor expression using estrogen receptor probing compound. J Immunoassay Immunochem. 2005; 26(4):295-301. Liu H, Ding Y, Voskuhl RR. PMID: 16153014.
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    77. Estriol treatment ameliorates disease in males with experimental autoimmune encephalomyelitis: implications for multiple sclerosis. J Neuroimmunol. 2004 Apr; 149(1-2):84-9. Palaszynski KM, Liu H, Loo KK, Voskuhl RR. PMID: 15020068.
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    78. Dysregulation of IL-10 and IL-12p40 in secondary progressive multiple sclerosis. J Neuroimmunol. 2004 Jan; 146(1-2):209-15. Soldan SS, Alvarez Retuerto AI, Sicotte NL, Voskuhl RR. PMID: 14698865.
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    79. Androgens are protective in experimental autoimmune encephalomyelitis: implications for multiple sclerosis. J Neuroimmunol. 2004 Jan; 146(1-2):144-52. Palaszynski KM, Loo KK, Ashouri JF, Liu HB, Voskuhl RR. PMID: 14698857.
      View in: PubMed   Mentions: 65     Fields:    Translation:Animals
    80. Estrogen receptor alpha mediates estrogen's immune protection in autoimmune disease. J Immunol. 2003 Dec 15; 171(12):6936-40. Liu HB, Loo KK, Palaszynski K, Ashouri J, Lubahn DB, Voskuhl RR. PMID: 14662901.
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    81. Immune modulation in multiple sclerosis patients treated with the pregnancy hormone estriol. J Immunol. 2003 Dec 01; 171(11):6267-74. Soldan SS, Alvarez Retuerto AI, Sicotte NL, Voskuhl RR. PMID: 14634144.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansCellsCTClinical Trials
    82. Comparison of multiple sclerosis lesions at 1.5 and 3.0 Tesla. Invest Radiol. 2003 Jul; 38(7):423-7. Sicotte NL, Voskuhl RR, Bouvier S, Klutch R, Cohen MS, Mazziotta JC. PMID: 12821856.
      View in: PubMed   Mentions: 46     Fields:    Translation:Humans
    83. Hormone-based therapies in MS. Int MS J. 2003 Jun; 10(2):60-6. Voskuhl RR. PMID: 14561384.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    84. Experimental autoimmune encephalomyelitis relapses are reduced in heterozygous golli MBP knockout mice. J Neuroimmunol. 2003 Jun; 139(1-2):44-50. Voskuhl RR, Pribyl TM, Kampf K, Handley V, Liu HB, Feng J, Campagnoni CW, Soldan SS, Messing A, Campagnoni AT. PMID: 12799019.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    85. Gender issues and multiple sclerosis. Curr Neurol Neurosci Rep. 2002 May; 2(3):277-86. Voskuhl RR. PMID: 11937007.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    86. Onset of multiple sclerosis associated with anti-TNF therapy. Neurology. 2001 Nov 27; 57(10):1885-8. Sicotte NL, Voskuhl RR. PMID: 11723281.
      View in: PubMed   Mentions: 95     Fields:    Translation:Humans
    87. "Classic" myelin basic proteins are expressed in lymphoid tissue macrophages. J Neuroimmunol. 2001 May 01; 116(1):83-93. Liu H, MacKenzie-Graham AJ, Palaszynski K, Liva S, Voskuhl RR. PMID: 11311333.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    88. Mice resistant to experimental autoimmune encephalomyelitis have increased thymic expression of myelin basic protein and increased MBP specific T cell tolerance. J Neuroimmunol. 2001 Apr 02; 115(1-2):118-26. Liu H, MacKenzie-Graham AJ, Kim S, Voskuhl RR. PMID: 11282161.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    89. Decreased IL-12 production underlies the decreased ability of male lymph node cells to induce experimental autoimmune encephalomyelitis. J Immunol. 1999 May 01; 162(9):5561-8. Kim S, Voskuhl RR. PMID: 10228038.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCellsPHPublic Health
    90. Estriol ameliorates autoimmune demyelinating disease: implications for multiple sclerosis. Neurology. 1999 Apr 12; 52(6):1230-8. Kim S, Liva SM, Dalal MA, Verity MA, Voskuhl RR. PMID: 10214749.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    91. Temporal kinetics and cellular phenotype of TNF p55/p75 receptors in experimental allergic encephalomyelitis. J Neuroimmunol. 1999 Mar 01; 95(1-2):19-34. Kahn MA, Dopp JM, Liva S, MacKenzie-Graham AJ, Chang R, Huang A, Nazarian R, Dell'Albani P, Condorelli D, Voskuhl RR, de Vellis J. PMID: 10229112.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    92. Myelin protein expression in lymphoid tissues: implications for peripheral tolerance. Immunol Rev. 1998 Aug; 164:81-92. Voskuhl RR. PMID: 9795766.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    93. Antisense knockdown of inducible nitric oxide synthase inhibits induction of experimental autoimmune encephalomyelitis in SJL/J mice. J Immunol. 1998 Mar 15; 160(6):2560-4. Ding M, Zhang M, Wong JL, Rogers NE, Ignarro LJ, Voskuhl RR. PMID: 9510151.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    94. Myelin protein expression is increased in lymph nodes of mice with relapsing experimental autoimmune encephalomyelitis. J Immunol. 1997 Nov 01; 159(9):4602-10. MacKenzie-Graham AJ, Pribyl TM, Kim S, Porter VR, Campagnoni AT, Voskuhl RR. PMID: 9379062.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    95. Gender differences of inducible nitric oxide production in SJL/J mice with experimental autoimmune encephalomyelitis. J Neuroimmunol. 1997 Jul; 77(1):99-106. Ding M, Wong JL, Rogers NE, Ignarro LJ, Voskuhl RR. PMID: 9209274.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    96. Testosterone therapy ameliorates experimental autoimmune encephalomyelitis and induces a T helper 2 bias in the autoantigen-specific T lymphocyte response. J Immunol. 1997 Jul 01; 159(1):3-6. Dalal M, Kim S, Voskuhl RR. PMID: 9200430.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    97. Multiple sclerosis: re-expression of a developmental gene in chronic lesions correlates with remyelination. Ann Neurol. 1997 Jun; 41(6):797-805. Capello E, Voskuhl RR, McFarland HF, Raine CS. PMID: 9189041.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    98. Exon 2 containing myelin basic protein (MBP) transcripts are expressed in lesions of experimental allergic encephalomyelitis (EAE). J Neuroimmunol. 1997 Jan; 72(1):21-5. Nagasato K, Farris RW, Dubois-Dalcq M, Voskuhl RR. PMID: 9003242; PMCID: PMC7112849.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    99. Antisense blockade of inducible nitric oxide synthase in glial cells derived from adult SJL mice. Neurosci Lett. 1996 Dec 13; 220(2):89-92. Ding M, Zhang M, Wong JL, Voskuhl RR, Ellison GW. PMID: 8981480.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    100. Epitope spreading occurs in active but not passive EAE induced by myelin basic protein. J Neuroimmunol. 1996 Nov; 70(2):103-11. Voskuhl RR, Farris RW, Nagasato K, McFarland HF, Dalcq MD. PMID: 8898718.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCellsPHPublic Health
    101. Human T lymphocytes specific for the immunodominant 83-99 epitope of myelin basic protein: recognition of golli MBP HOG 7. J Neurosci Res. 1996 Sep 15; 45(6):820-8. Tranquill LR, Skinner E, Campagnoni C, Vergelli M, Hemmer B, Muraro P, Martin R, McFarland HF, Campagnoni AT, Voskuhl RR. PMID: 8892094.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    102. Strain-related differences in the ability of T lymphocytes to recognize proteins encoded by the golli-myelin basic protein gene. J Neuroimmunol. 1996 Aug; 68(1-2):121-9. Pitchekian-Halabi H, Campagnoni CW, Skinner E, Kampf K, Campagnoni AT, Voskuhl RR. PMID: 8784268.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    103. Gender differences in autoimmune demyelination in the mouse: implications for multiple sclerosis. Ann Neurol. 1996 Jun; 39(6):724-33. Voskuhl RR, Pitchekian-Halabi H, MacKenzie-Graham A, McFarland HF, Raine CS. PMID: 8651644.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    104. DR2/DQw1 inheritance and haplotype sharing in affected siblings from multiple sclerosis families. Ann Neurol. 1996 Jun; 39(6):804-7. Voskuhl RR, Goldstein AM, Simonis T, Davey RJ, McFarland HF. PMID: 8651654.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    105. Purification of immunologically active recombinant 21.5 kDa isoform of human myelin basic protein. Mol Immunol. 1995 Oct; 32(14-15):1131-41. Nye SH, Pelfrey CM, Burkwit JJ, Voskuhl RR, Lenardo MJ, Mueller JP. PMID: 8544862.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    106. Diversity of T-cell receptor V alpha, V beta, and CDR3 expression by myelin basic protein-specific human T-cell clones. Neurology. 1995 Oct; 45(10):1919-22. Richert JR, Robinson ED, Camphausen K, Martin R, Voskuhl RR, Faerber MA, McFarland HF, Hurley CK. PMID: 7477993.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    107. T-cell receptor alpha and beta CDR3 expression by myelin basic protein-specific human T-cell clones. Ann N Y Acad Sci. 1995 Jul 07; 756:317-8. Richert JR, Robinson ED, Camphausen K, Hastings E, Martin R, Voskuhl R, McFarland HF. PMID: 7544080.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    108. HLA restriction and TCR usage of T lymphocytes specific for a novel candidate autoantigen, X2 MBP, in multiple sclerosis. J Immunol. 1994 Nov 15; 153(10):4834-44. Voskuhl RR, Robinson ED, Segal BM, Tranquill L, Camphausen K, Albert PS, Richert JR, McFarland HF. PMID: 7525716.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    109. Experimental allergic encephalomyelitis induced by the peptide encoded by exon 2 of the MBP gene, a peptide implicated in remyelination. J Neuroimmunol. 1994 Apr; 51(1):7-19. Segal BM, Raine CS, McFarlin DE, Voskuhl RR, McFarland HF. PMID: 7512579; PMCID: PMC7119711.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    110. Myelin basic protein-specific T-cell responses in identical twins discordant or concordant for multiple sclerosis. Ann Neurol. 1993 Oct; 34(4):524-35. Martin R, Voskuhl R, Flerlage M, McFarlin DE, McFarland HF. PMID: 7692808.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    111. A novel candidate autoantigen in a multiplex family with multiple sclerosis: prevalence of T-lymphocytes specific for an MBP epitope unique to myelination. J Neuroimmunol. 1993 Jul; 46(1-2):137-44. Voskuhl RR, McFarlin DE, Tranquill LR, Deibler G, Stone R, Maloni H, McFarland HF. PMID: 7689584; PMCID: PMC7119790.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    112. A functional basis for the association of HLA class II genes and susceptibility to multiple sclerosis: cellular immune responses to myelin basic protein in a multiplex family. J Neuroimmunol. 1993 Feb; 42(2):199-207. Voskuhl RR, Martin R, McFarland HF. PMID: 7679119.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    113. T-lymphocyte recognition of a portion of myelin basic protein encoded by an exon expressed during myelination. J Neuroimmunol. 1993 Feb; 42(2):187-91. Voskuhl RR, McFarlin DE, Stone R, McFarland HF. PMID: 7679118; PMCID: PMC7119506.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    114. T helper 1 (Th1) functional phenotype of human myelin basic protein-specific T lymphocytes. Autoimmunity. 1993; 15(2):137-43. Voskuhl RR, Martin R, Bergman C, Dalal M, Ruddle NH, McFarland HF. PMID: 7692995.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    115. HTLV-I-specific cytotoxic T lymphocytes in the cerebrospinal fluid of patients with HTLV-I-associated neurological disease. Ann Neurol. 1992 Nov; 32(5):651-7. Jacobson S, McFarlin DE, Robinson S, Voskuhl R, Martin R, Brewah A, Newell AJ, Koenig S. PMID: 1449245.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
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