Allan Mackenzie-Graham

Title(s)Associate Professor-in-Residence, Neurology
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    The Mechanism of Gray Matter Atrophy in Experimental Autoimmune Encephalomyelitis
    NIH R21NS121806Apr 1, 2021 - Sep 30, 2022
    Role: Principal Investigator
    Coupling neuroimaging with CLARITY and single cell genomics to dissect sex differences in the developing brain
    NIH R01HD100298Apr 1, 2020 - Jan 31, 2025
    Role: Co-Principal Investigator
    Discriminating sex chromosome and hormonal effects on brain sexual dimorphisms
    NIH R21HD090637Sep 1, 2017 - Aug 31, 2020
    Role: Co-Principal Investigator
    Bringing CLARITY to EAE
    NIH R01NS086981Mar 1, 2015 - Feb 29, 2020
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Estrogen receptor beta in astrocytes modulates cognitive function in mid-age female mice. Nat Commun. 2023 09 28; 14(1):6044. Itoh N, Itoh Y, Meyer CE, Suen TT, Cortez-Delgado D, Rivera Lomeli M, Wendin S, Somepalli SS, Golden LC, MacKenzie-Graham A, Voskuhl RR. PMID: 37758709; PMCID: PMC10533869.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    2. Neuroprotection in Cerebral Cortex Induced by the Pregnancy Hormone Estriol. Lab Invest. 2023 08; 103(8):100189. Meyer CE, Smith AW, Padilla-Requerey AA, Farkhondeh V, Itoh N, Itoh Y, Gao JL, Herbig PD, Nguyen Q, Ngo KH, Oberoi MR, Siddarth P, Voskuhl RR, MacKenzie-Graham A. PMID: 37245852.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    3. Overexpression of VIPR2 in mice results in microencephaly with paradoxical increased white matter volume. Exp Neurol. 2023 04; 362:114339. Ago Y, Van C, Condro MC, Hrncir H, Diep AL, Rajbhandari AK, Fanselow MS, Hashimoto H, MacKenzie-Graham AJ, Waschek JA. PMID: 36717013.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    4. A Cross-Species Neuroimaging Study of Sex Chromosome Dosage Effects on Human and Mouse Brain Anatomy. J Neurosci. 2023 02 22; 43(8):1321-1333. Guma E, Beauchamp A, Liu S, Levitis E, Clasen LS, Torres E, Blumenthal J, Lalonde F, Qiu LR, Hrncir H, MacKenzie-Graham A, Yang X, Arnold AP, Lerch JP, Raznahan A. PMID: 36631267; PMCID: PMC9987571.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    5. Chronic experimental autoimmune encephalomyelitis is an excellent model to study neuroaxonal degeneration in multiple sclerosis. Front Mol Neurosci. 2022; 15:1024058. Voskuhl RR, MacKenzie-Graham A. PMID: 36340686; PMCID: PMC9629273.
      View in: PubMed   Mentions: 6  
    6. Decreased neurofilament light chain levels in estriol-treated multiple sclerosis. Ann Clin Transl Neurol. 2022 08; 9(8):1316-1320. Voskuhl R, Kuhle J, Siddarth P, Itoh N, Patel K, MacKenzie-Graham A. PMID: 35770318; PMCID: PMC9380170.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    7. Targeted deletion of PAC1 receptors in retinal neurons enhances neuron loss and axonopathy in a model of multiple sclerosis and optic neuritis. Neurobiol Dis. 2021 12; 160:105524. Van C, Condro MC, Ko HH, Hoang AQ, Zhu R, Lov K, Ricaflanca PT, Diep AL, Nguyen NNM, Lipshutz GS, MacKenzie-Graham A, Waschek JA. PMID: 34610465.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    8. Sex differences in brain atrophy in multiple sclerosis. Biol Sex Differ. 2020 08 28; 11(1):49. Voskuhl RR, Patel K, Paul F, Gold SM, Scheel M, Kuchling J, Cooper G, Asseyer S, Chien C, Brandt AU, Meyer CE, MacKenzie-Graham A. PMID: 32859258; PMCID: PMC7456053.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    9. Ischemic axonal injury up-regulates MARK4 in cortical neurons and primes tau phosphorylation and aggregation. Acta Neuropathol Commun. 2019 08 20; 7(1):135. Hayden EY, Putman J, Nunez S, Shin WS, Oberoi M, Charreton M, Dutta S, Li Z, Komuro Y, Joy MT, Bitan G, MacKenzie-Graham A, Jiang L, Hinman JD. PMID: 31429800; PMCID: PMC6700776.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    10. Axonal damage in spinal cord is associated with gray matter atrophy in sensorimotor cortex in experimental autoimmune encephalomyelitis. Mult Scler. 2020 03; 26(3):294-303. Meyer CE, Gao JL, Cheng JY, Oberoi MR, Johnsonbaugh H, Lepore S, Kurth F, Thurston MJ, Itoh N, Patel KR, Voskuhl RR, MacKenzie-Graham A. PMID: 30843756; PMCID: PMC6957766.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    11. Estriol-mediated neuroprotection in multiple sclerosis localized by voxel-based morphometry. Brain Behav. 2018 09; 8(9):e01086. MacKenzie-Graham A, Brook J, Kurth F, Itoh Y, Meyer C, Montag MJ, Wang HJ, Elashoff R, Voskuhl RR. PMID: 30144306; PMCID: PMC6160650.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    12. In vivo magnetic resonance images reveal neuroanatomical sex differences through the application of voxel-based morphometry in C57BL/6 mice. Neuroimage. 2017 12; 163:197-205. Meyer CE, Kurth F, Lepore S, Gao JL, Johnsonbaugh H, Oberoi MR, Sawiak SJ, MacKenzie-Graham A. PMID: 28923275; PMCID: PMC5716897.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    13. Enhancing image quality in cleared tissue with adaptive optics. J Biomed Opt. 2016 12 01; 21(12):121508. Reinig MR, Novak SW, Tao X, Bentolila LA, Roberts DG, MacKenzie-Graham A, Godshalk SE, Raven MA, Knowles DW, Kubby J. PMID: 27735018; PMCID: PMC5997003.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    14. Bedside to bench to bedside research: Estrogen receptor beta ligand as a candidate neuroprotective treatment for multiple sclerosis. J Neuroimmunol. 2017 03 15; 304:63-71. Itoh N, Kim R, Peng M, DiFilippo E, Johnsonbaugh H, MacKenzie-Graham A, Voskuhl RR. PMID: 27771018; PMCID: PMC5806698.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    15. Disability-Specific Atlases of Gray Matter Loss in Relapsing-Remitting Multiple Sclerosis. JAMA Neurol. 2016 Aug 01; 73(8):944-53. MacKenzie-Graham A, Kurth F, Itoh Y, Wang HJ, Montag MJ, Elashoff R, Voskuhl RR. PMID: 27294295; PMCID: PMC6415681.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCTClinical Trials
    16. Optical Clearing of the Mouse Central Nervous System Using Passive CLARITY. J Vis Exp. 2016 06 30; (112). Roberts DG, Johnsonbaugh HB, Spence RD, MacKenzie-Graham A. PMID: 27404319; PMCID: PMC4993291.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    17. Estriol combined with glatiramer acetate for women with relapsing-remitting multiple sclerosis: a randomised, placebo-controlled, phase 2 trial. Lancet Neurol. 2016 Jan; 15(1):35-46. Voskuhl RR, Wang H, Wu TC, Sicotte NL, Nakamura K, Kurth F, Itoh N, Bardens J, Bernard JT, Corboy JR, Cross AH, Dhib-Jalbut S, Ford CC, Frohman EM, Giesser B, Jacobs D, Kasper LH, Lynch S, Parry G, Racke MK, Reder AT, Rose J, Wingerchuk DM, MacKenzie-Graham AJ, Arnold DL, Tseng CH, Elashoff R. PMID: 26621682.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansCTClinical Trials
    18. Bringing CLARITY to gray matter atrophy. Neuroimage. 2014 Nov 01; 101:625-32. Spence RD, Kurth F, Itoh N, Mongerson CR, Wailes SH, Peng MS, MacKenzie-Graham AJ. PMID: 25038439; PMCID: PMC4437539.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    19. Shifting brain asymmetry: the link between meditation and structural lateralization. Soc Cogn Affect Neurosci. 2015 Jan; 10(1):55-61. Kurth F, MacKenzie-Graham A, Toga AW, Luders E. PMID: 24643652; PMCID: PMC4994843.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    20. Neuroprotective effects of testosterone treatment in men with multiple sclerosis. Neuroimage Clin. 2014; 4:454-60. Kurth F, Luders E, Sicotte NL, Gaser C, Giesser BS, Swerdloff RS, Montag MJ, Voskuhl RR, Mackenzie-Graham A. PMID: 24634831; PMCID: PMC3952353.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCTClinical Trials
    21. In vivo vs. ex vivo Magnetic Resonance Imaging In Mice. Front Neuroinform. 2012; 6:19. Mackenzie-Graham A. PMID: 22629243; PMCID: PMC3354346.
      View in: PubMed   Mentions: 1  
    22. Estrogen treatment prevents gray matter atrophy in experimental autoimmune encephalomyelitis. J Neurosci Res. 2012 Jul; 90(7):1310-23. MacKenzie-Graham AJ, Rinek GA, Avedisian A, Morales LB, Umeda E, Boulat B, Jacobs RE, Toga AW, Voskuhl RR. PMID: 22411609; PMCID: PMC3350614.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    23. Cortical atrophy in experimental autoimmune encephalomyelitis: in vivo imaging. Neuroimage. 2012 Mar; 60(1):95-104. MacKenzie-Graham A, Rinek GA, Avedisian A, Gold SM, Frew AJ, Aguilar C, Lin DR, Umeda E, Voskuhl RR, Alger JR. PMID: 22182769; PMCID: PMC3293104.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    24. Efficient, Distributed and Interactive Neuroimaging Data Analysis Using the LONI Pipeline. Front Neuroinform. 2009; 3:22. Dinov ID, Van Horn JD, Lozev KM, Magsipoc R, Petrosyan P, Liu Z, Mackenzie-Graham A, Eggert P, Parker DS, Toga AW. PMID: 19649168; PMCID: PMC2718780.
      View in: PubMed   Mentions: 90  
    25. Purkinje cell loss in experimental autoimmune encephalomyelitis. Neuroimage. 2009 Dec; 48(4):637-51. MacKenzie-Graham A, Tiwari-Woodruff SK, Sharma G, Aguilar C, Vo KT, Strickland LV, Morales L, Fubara B, Martin M, Jacobs RE, Johnson GA, Toga AW, Voskuhl RR. PMID: 19589388; PMCID: PMC2754586.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    26. Provenance in neuroimaging. Neuroimage. 2008 Aug 01; 42(1):178-95. Mackenzie-Graham AJ, Van Horn JD, Woods RP, Crawford KL, Toga AW. PMID: 18519166; PMCID: PMC2664747.
      View in: PubMed   Mentions: 34     Fields:    
    27. Brain atlases and neuroanatomic imaging. Methods Mol Biol. 2007; 401:183-94. MacKenzie-Graham A, Boline J, Toga AW. PMID: 18368367.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    28. Multimodal, multidimensional models of mouse brain. Epilepsia. 2007; 48 Suppl 4:75-81. Mackenzie-Graham AJ, Lee EF, Dinov ID, Yuan H, Jacobs RE, Toga AW. PMID: 17767578; PMCID: PMC3192853.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    29. Cerebellar cortical atrophy in experimental autoimmune encephalomyelitis. Neuroimage. 2006 Sep; 32(3):1016-23. MacKenzie-Graham A, Tinsley MR, Shah KP, Aguilar C, Strickland LV, Boline J, Martin M, Morales L, Shattuck DW, Jacobs RE, Voskuhl RR, Toga AW. PMID: 16806982.
      View in: PubMed   Mentions: 34     Fields:    Translation:Animals
    30. LONI visualization environment. J Digit Imaging. 2006 Jun; 19(2):148-58. Dinov ID, Valentino D, Shin BC, Konstantinidis F, Hu G, MacKenzie-Graham A, Lee EF, Shattuck D, Ma J, Schwartz C, Toga AW. PMID: 16598642; PMCID: PMC3045182.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    31. A multimodal, multidimensional atlas of the C57BL/6J mouse brain. J Anat. 2004 Feb; 204(2):93-102. MacKenzie-Graham A, Lee EF, Dinov ID, Bota M, Shattuck DW, Ruffins S, Yuan H, Konstantinidis F, Pitiot A, Ding Y, Hu G, Jacobs RE, Toga AW. PMID: 15032916; PMCID: PMC1571243.
      View in: PubMed   Mentions: 91     Fields:    Translation:Animals
    32. The informatics of a C57BL/6J mouse brain atlas. Neuroinformatics. 2003; 1(4):397-410. MacKenzie-Graham A, Jones ES, Shattuck DW, Dinov ID, Bota M, Toga AW. PMID: 15043223.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    33. "Classic" myelin basic proteins are expressed in lymphoid tissue macrophages. J Neuroimmunol. 2001 May 01; 116(1):83-93. Liu H, MacKenzie-Graham AJ, Palaszynski K, Liva S, Voskuhl RR. PMID: 11311333.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    34. Mice resistant to experimental autoimmune encephalomyelitis have increased thymic expression of myelin basic protein and increased MBP specific T cell tolerance. J Neuroimmunol. 2001 Apr 02; 115(1-2):118-26. Liu H, MacKenzie-Graham AJ, Kim S, Voskuhl RR. PMID: 11282161.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    35. Temporal kinetics and cellular phenotype of TNF p55/p75 receptors in experimental allergic encephalomyelitis. J Neuroimmunol. 1999 Mar 01; 95(1-2):19-34. Kahn MA, Dopp JM, Liva S, MacKenzie-Graham AJ, Chang R, Huang A, Nazarian R, Dell'Albani P, Condorelli D, Voskuhl RR, de Vellis J. PMID: 10229112.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    36. Myelin protein expression is increased in lymph nodes of mice with relapsing experimental autoimmune encephalomyelitis. J Immunol. 1997 Nov 01; 159(9):4602-10. MacKenzie-Graham AJ, Pribyl TM, Kim S, Porter VR, Campagnoni AT, Voskuhl RR. PMID: 9379062.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    37. Inducible nitric oxide synthase and nitric oxide production by oligodendrocytes. J Neurosci Res. 1997 May 15; 48(4):372-84. Merrill JE, Murphy SP, Mitrovic B, Mackenzie-Graham A, Dopp JC, Ding M, Griscavage J, Ignarro LJ, Lowenstein CJ. PMID: 9169863.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    38. Differential expression, cytokine modulation, and specific functions of type-1 and type-2 tumor necrosis factor receptors in rat glia. J Neuroimmunol. 1997 May; 75(1-2):104-12. Dopp JM, Mackenzie-Graham A, Otero GC, Merrill JE. PMID: 9143243.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    39. Gender differences in autoimmune demyelination in the mouse: implications for multiple sclerosis. Ann Neurol. 1996 Jun; 39(6):724-33. Voskuhl RR, Pitchekian-Halabi H, MacKenzie-Graham A, McFarland HF, Raine CS. PMID: 8651644.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    40. The role of nitric oxide in glial pathology. Ann N Y Acad Sci. 1994 Nov 17; 738:436-46. Mitrovic B, St Pierre BA, Mackenzie-Graham AJ, Merrill JE. PMID: 7832453.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    41. Differential sensitivity to nitric oxide in immortalized, cloned murine oligodendrocyte cell lines. Dev Neurosci. 1994; 16(3-4):162-71. Mackenzie-Graham AJ, Mitrovic B, Smoll A, Merrill JE. PMID: 7535681.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
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