Allan Mackenzie-Graham

Title(s)	Associate Professor-in-Residence, Neurology
School	Medicine
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Research

Research Activities and Funding

The Mechanism of Gray Matter Atrophy in Experimental Autoimmune Encephalomyelitis
NIH R21NS121806Apr 1, 2021 - Sep 30, 2022
Role: Principal Investigator

Coupling neuroimaging with CLARITY and single cell genomics to dissect sex differences in the developing brain
NIH R01HD100298Apr 1, 2020 - Jan 31, 2025
Role: Co-Principal Investigator

Discriminating sex chromosome and hormonal effects on brain sexual dimorphisms
NIH R21HD090637Sep 1, 2017 - Aug 31, 2020
Role: Co-Principal Investigator

Bringing CLARITY to EAE
NIH R01NS086981Mar 1, 2015 - Feb 29, 2020
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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Mouse Brain Extractor: Brain segmentation of mouse MRI using global positional encoding and SwinUNETR. bioRxiv. 2024 Sep 08. Kim Y, Hrncir H, Meyer CE, Tabbaa M, Moats RA, Levitt P, Harris NG, MacKenzie-Graham A, Shattuck DW. PMID: 39282435; PMCID: PMC11398355.

View in: PubMed Mentions:
Estrogen receptor beta in astrocytes modulates cognitive function in mid-age female mice. Nat Commun. 2023 09 28; 14(1):6044. Itoh N, Itoh Y, Meyer CE, Suen TT, Cortez-Delgado D, Rivera Lomeli M, Wendin S, Somepalli SS, Golden LC, MacKenzie-Graham A, Voskuhl RR. PMID: 37758709; PMCID: PMC10533869.

View in: PubMed Mentions: 7 Fields:
Bio Biology Sci Science
Translation:Animals Cells
Neuroprotection in Cerebral Cortex Induced by the Pregnancy Hormone Estriol. Lab Invest. 2023 08; 103(8):100189. Meyer CE, Smith AW, Padilla-Requerey AA, Farkhondeh V, Itoh N, Itoh Y, Gao JL, Herbig PD, Nguyen Q, Ngo KH, Oberoi MR, Siddarth P, Voskuhl RR, MacKenzie-Graham A. PMID: 37245852.

View in: PubMed Mentions: 4 Fields:
Cli Clinical Laboratory Techniques Pat Pathology
Translation:Animals
Overexpression of VIPR2 in mice results in microencephaly with paradoxical increased white matter volume. Exp Neurol. 2023 04; 362:114339. Ago Y, Van C, Condro MC, Hrncir H, Diep AL, Rajbhandari AK, Fanselow MS, Hashimoto H, MacKenzie-Graham AJ, Waschek JA. PMID: 36717013.

View in: PubMed Mentions: 1 Fields:
Neu Neurology
Translation:Humans Animals
A Cross-Species Neuroimaging Study of Sex Chromosome Dosage Effects on Human and Mouse Brain Anatomy. J Neurosci. 2023 02 22; 43(8):1321-1333. Guma E, Beauchamp A, Liu S, Levitis E, Clasen LS, Torres E, Blumenthal J, Lalonde F, Qiu LR, Hrncir H, MacKenzie-Graham A, Yang X, Arnold AP, Lerch JP, Raznahan A. PMID: 36631267; PMCID: PMC9987571.

View in: PubMed Mentions: 6 Fields:
Neu Neurology
Translation:Humans Animals Cells
Chronic experimental autoimmune encephalomyelitis is an excellent model to study neuroaxonal degeneration in multiple sclerosis. Front Mol Neurosci. 2022; 15:1024058. Voskuhl RR, MacKenzie-Graham A. PMID: 36340686; PMCID: PMC9629273.

View in: PubMed Mentions: 9
Decreased neurofilament light chain levels in estriol-treated multiple sclerosis. Ann Clin Transl Neurol. 2022 08; 9(8):1316-1320. Voskuhl R, Kuhle J, Siddarth P, Itoh N, Patel K, MacKenzie-Graham A. PMID: 35770318; PMCID: PMC9380170.

View in: PubMed Mentions: 7 Fields:
Neu Neurology
Translation:Humans Cells
Targeted deletion of PAC1 receptors in retinal neurons enhances neuron loss and axonopathy in a model of multiple sclerosis and optic neuritis. Neurobiol Dis. 2021 12; 160:105524. Van C, Condro MC, Ko HH, Hoang AQ, Zhu R, Lov K, Ricaflanca PT, Diep AL, Nguyen NNM, Lipshutz GS, MacKenzie-Graham A, Waschek JA. PMID: 34610465.

View in: PubMed Mentions: 8 Fields:
Neu Neurology
Translation:Animals Cells
Sex differences in brain atrophy in multiple sclerosis. Biol Sex Differ. 2020 08 28; 11(1):49. Voskuhl RR, Patel K, Paul F, Gold SM, Scheel M, Kuchling J, Cooper G, Asseyer S, Chien C, Brandt AU, Meyer CE, MacKenzie-Graham A. PMID: 32859258; PMCID: PMC7456053.

View in: PubMed Mentions: 42 Fields:
Phy Physiology
Translation:Humans
Ischemic axonal injury up-regulates MARK4 in cortical neurons and primes tau phosphorylation and aggregation. Acta Neuropathol Commun. 2019 08 20; 7(1):135. Hayden EY, Putman J, Nunez S, Shin WS, Oberoi M, Charreton M, Dutta S, Li Z, Komuro Y, Joy MT, Bitan G, MacKenzie-Graham A, Jiang L, Hinman JD. PMID: 31429800; PMCID: PMC6700776.

View in: PubMed Mentions: 10 Fields:
Neu Neurology
Translation:Humans Animals Cells
Axonal damage in spinal cord is associated with gray matter atrophy in sensorimotor cortex in experimental autoimmune encephalomyelitis. Mult Scler. 2020 03; 26(3):294-303. Meyer CE, Gao JL, Cheng JY, Oberoi MR, Johnsonbaugh H, Lepore S, Kurth F, Thurston MJ, Itoh N, Patel KR, Voskuhl RR, MacKenzie-Graham A. PMID: 30843756; PMCID: PMC6957766.

View in: PubMed Mentions: 8 Fields:
Neu Neurology
Translation:Animals
Estriol-mediated neuroprotection in multiple sclerosis localized by voxel-based morphometry. Brain Behav. 2018 09; 8(9):e01086. MacKenzie-Graham A, Brook J, Kurth F, Itoh Y, Meyer C, Montag MJ, Wang HJ, Elashoff R, Voskuhl RR. PMID: 30144306; PMCID: PMC6160650.

View in: PubMed Mentions: 15 Fields:
Beh Behavioral Sciences Bra Brain
Translation:Humans
In vivo magnetic resonance images reveal neuroanatomical sex differences through the application of voxel-based morphometry in C57BL/6 mice. Neuroimage. 2017 12; 163:197-205. Meyer CE, Kurth F, Lepore S, Gao JL, Johnsonbaugh H, Oberoi MR, Sawiak SJ, MacKenzie-Graham A. PMID: 28923275; PMCID: PMC5716897.

View in: PubMed Mentions: 18 Fields:
Dia Diagnostic Imaging
Translation:Animals
Enhancing image quality in cleared tissue with adaptive optics. J Biomed Opt. 2016 12 01; 21(12):121508. Reinig MR, Novak SW, Tao X, Bentolila LA, Roberts DG, MacKenzie-Graham A, Godshalk SE, Raven MA, Knowles DW, Kubby J. PMID: 27735018; PMCID: PMC5997003.

View in: PubMed Mentions: 1 Fields:
Bio Biomedical Engineering Oph Ophthalmology
Translation:Animals Cells
Bedside to bench to bedside research: Estrogen receptor beta ligand as a candidate neuroprotective treatment for multiple sclerosis. J Neuroimmunol. 2017 03 15; 304:63-71. Itoh N, Kim R, Peng M, DiFilippo E, Johnsonbaugh H, MacKenzie-Graham A, Voskuhl RR. PMID: 27771018; PMCID: PMC5806698.

View in: PubMed Mentions: 20 Fields:
All Allergy and Immunology Neu Neurology
Translation:Animals
Disability-Specific Atlases of Gray Matter Loss in Relapsing-Remitting Multiple Sclerosis. JAMA Neurol. 2016 Aug 01; 73(8):944-53. MacKenzie-Graham A, Kurth F, Itoh Y, Wang HJ, Montag MJ, Elashoff R, Voskuhl RR. PMID: 27294295; PMCID: PMC6415681.

View in: PubMed Mentions: 15 Fields:
Neu Neurology
Translation:Humans CTClinical Trials
Optical Clearing of the Mouse Central Nervous System Using Passive CLARITY. J Vis Exp. 2016 06 30; (112). Roberts DG, Johnsonbaugh HB, Spence RD, MacKenzie-Graham A. PMID: 27404319; PMCID: PMC4993291.

View in: PubMed Mentions: 10 Fields:
Bio Biology Med Medicine (General)
Translation:Animals
Estriol combined with glatiramer acetate for women with relapsing-remitting multiple sclerosis: a randomised, placebo-controlled, phase 2 trial. Lancet Neurol. 2016 Jan; 15(1):35-46. Voskuhl RR, Wang H, Wu TC, Sicotte NL, Nakamura K, Kurth F, Itoh N, Bardens J, Bernard JT, Corboy JR, Cross AH, Dhib-Jalbut S, Ford CC, Frohman EM, Giesser B, Jacobs D, Kasper LH, Lynch S, Parry G, Racke MK, Reder AT, Rose J, Wingerchuk DM, MacKenzie-Graham AJ, Arnold DL, Tseng CH, Elashoff R. PMID: 26621682.

View in: PubMed Mentions: 85 Fields:
Neu Neurology
Translation:Humans CTClinical Trials
Bringing CLARITY to gray matter atrophy. Neuroimage. 2014 Nov 01; 101:625-32. Spence RD, Kurth F, Itoh N, Mongerson CR, Wailes SH, Peng MS, MacKenzie-Graham AJ. PMID: 25038439; PMCID: PMC4437539.

View in: PubMed Mentions: 21 Fields:
Dia Diagnostic Imaging
Translation:Animals
Shifting brain asymmetry: the link between meditation and structural lateralization. Soc Cogn Affect Neurosci. 2015 Jan; 10(1):55-61. Kurth F, MacKenzie-Graham A, Toga AW, Luders E. PMID: 24643652; PMCID: PMC4994843.

View in: PubMed Mentions: 20 Fields:
Neu Neurology Soc Social Sciences
Translation:Humans
Neuroprotective effects of testosterone treatment in men with multiple sclerosis. Neuroimage Clin. 2014; 4:454-60. Kurth F, Luders E, Sicotte NL, Gaser C, Giesser BS, Swerdloff RS, Montag MJ, Voskuhl RR, Mackenzie-Graham A. PMID: 24634831; PMCID: PMC3952353.

View in: PubMed Mentions: 52 Fields:
Dia Diagnostic Imaging Neu Neurology
Translation:Humans CTClinical Trials
In vivo vs. ex vivo Magnetic Resonance Imaging In Mice. Front Neuroinform. 2012; 6:19. Mackenzie-Graham A. PMID: 22629243; PMCID: PMC3354346.

View in: PubMed Mentions: 1
Estrogen treatment prevents gray matter atrophy in experimental autoimmune encephalomyelitis. J Neurosci Res. 2012 Jul; 90(7):1310-23. MacKenzie-Graham AJ, Rinek GA, Avedisian A, Morales LB, Umeda E, Boulat B, Jacobs RE, Toga AW, Voskuhl RR. PMID: 22411609; PMCID: PMC3350614.

View in: PubMed Mentions: 15 Fields:
Neu Neurology
Translation:Animals
Cortical atrophy in experimental autoimmune encephalomyelitis: in vivo imaging. Neuroimage. 2012 Mar; 60(1):95-104. MacKenzie-Graham A, Rinek GA, Avedisian A, Gold SM, Frew AJ, Aguilar C, Lin DR, Umeda E, Voskuhl RR, Alger JR. PMID: 22182769; PMCID: PMC3293104.

View in: PubMed Mentions: 28 Fields:
Dia Diagnostic Imaging
Translation:Animals
Efficient, Distributed and Interactive Neuroimaging Data Analysis Using the LONI Pipeline. Front Neuroinform. 2009; 3:22. Dinov ID, Van Horn JD, Lozev KM, Magsipoc R, Petrosyan P, Liu Z, Mackenzie-Graham A, Eggert P, Parker DS, Toga AW. PMID: 19649168; PMCID: PMC2718780.

View in: PubMed Mentions: 91
Purkinje cell loss in experimental autoimmune encephalomyelitis. Neuroimage. 2009 Dec; 48(4):637-51. MacKenzie-Graham A, Tiwari-Woodruff SK, Sharma G, Aguilar C, Vo KT, Strickland LV, Morales L, Fubara B, Martin M, Jacobs RE, Johnson GA, Toga AW, Voskuhl RR. PMID: 19589388; PMCID: PMC2754586.

View in: PubMed Mentions: 52 Fields:
Dia Diagnostic Imaging
Translation:Animals Cells
Provenance in neuroimaging. Neuroimage. 2008 Aug 01; 42(1):178-95. Mackenzie-Graham AJ, Van Horn JD, Woods RP, Crawford KL, Toga AW. PMID: 18519166; PMCID: PMC2664747.

View in: PubMed Mentions: 34 Fields:
Dia Diagnostic Imaging
Brain atlases and neuroanatomic imaging. Methods Mol Biol. 2007; 401:183-94. MacKenzie-Graham A, Boline J, Toga AW. PMID: 18368367.

View in: PubMed Mentions: 7 Fields:
Mol Molecular Biology
Translation:Humans Animals
Multimodal, multidimensional models of mouse brain. Epilepsia. 2007; 48 Suppl 4:75-81. Mackenzie-Graham AJ, Lee EF, Dinov ID, Yuan H, Jacobs RE, Toga AW. PMID: 17767578; PMCID: PMC3192853.

View in: PubMed Mentions: 9 Fields:
Bra Brain Neu Neurology
Translation:Animals
Cerebellar cortical atrophy in experimental autoimmune encephalomyelitis. Neuroimage. 2006 Sep; 32(3):1016-23. MacKenzie-Graham A, Tinsley MR, Shah KP, Aguilar C, Strickland LV, Boline J, Martin M, Morales L, Shattuck DW, Jacobs RE, Voskuhl RR, Toga AW. PMID: 16806982.

View in: PubMed Mentions: 34 Fields:
Dia Diagnostic Imaging
Translation:Animals
LONI visualization environment. J Digit Imaging. 2006 Jun; 19(2):148-58. Dinov ID, Valentino D, Shin BC, Konstantinidis F, Hu G, MacKenzie-Graham A, Lee EF, Shattuck D, Ma J, Schwartz C, Toga AW. PMID: 16598642; PMCID: PMC3045182.

View in: PubMed Mentions: 10 Fields:
Dia Diagnostic Imaging Med Medical Informatics Rad Radiology
Translation:Humans
A multimodal, multidimensional atlas of the C57BL/6J mouse brain. J Anat. 2004 Feb; 204(2):93-102. MacKenzie-Graham A, Lee EF, Dinov ID, Bota M, Shattuck DW, Ruffins S, Yuan H, Konstantinidis F, Pitiot A, Ding Y, Hu G, Jacobs RE, Toga AW. PMID: 15032916; PMCID: PMC1571243.

View in: PubMed Mentions: 92 Fields:
Ana Anatomy
Translation:Animals
The informatics of a C57BL/6J mouse brain atlas. Neuroinformatics. 2003; 1(4):397-410. MacKenzie-Graham A, Jones ES, Shattuck DW, Dinov ID, Bota M, Toga AW. PMID: 15043223.

View in: PubMed Mentions: 25 Fields:
Med Medical Informatics Neu Neurology
Translation:Animals
"Classic" myelin basic proteins are expressed in lymphoid tissue macrophages. J Neuroimmunol. 2001 May 01; 116(1):83-93. Liu H, MacKenzie-Graham AJ, Palaszynski K, Liva S, Voskuhl RR. PMID: 11311333.

View in: PubMed Mentions: 10 Fields:
All Allergy and Immunology Neu Neurology
Translation:Animals Cells
Mice resistant to experimental autoimmune encephalomyelitis have increased thymic expression of myelin basic protein and increased MBP specific T cell tolerance. J Neuroimmunol. 2001 Apr 02; 115(1-2):118-26. Liu H, MacKenzie-Graham AJ, Kim S, Voskuhl RR. PMID: 11282161.

View in: PubMed Mentions: 6 Fields:
All Allergy and Immunology Neu Neurology
Translation:Animals Cells
Temporal kinetics and cellular phenotype of TNF p55/p75 receptors in experimental allergic encephalomyelitis. J Neuroimmunol. 1999 Mar 01; 95(1-2):19-34. Kahn MA, Dopp JM, Liva S, MacKenzie-Graham AJ, Chang R, Huang A, Nazarian R, Dell'Albani P, Condorelli D, Voskuhl RR, de Vellis J. PMID: 10229112.

View in: PubMed Mentions: 3 Fields:
All Allergy and Immunology Neu Neurology
Translation:Animals Cells
Myelin protein expression is increased in lymph nodes of mice with relapsing experimental autoimmune encephalomyelitis. J Immunol. 1997 Nov 01; 159(9):4602-10. MacKenzie-Graham AJ, Pribyl TM, Kim S, Porter VR, Campagnoni AT, Voskuhl RR. PMID: 9379062.

View in: PubMed Mentions: 6 Fields:
All Allergy and Immunology
Translation:Animals Cells
Inducible nitric oxide synthase and nitric oxide production by oligodendrocytes. J Neurosci Res. 1997 May 15; 48(4):372-84. Merrill JE, Murphy SP, Mitrovic B, Mackenzie-Graham A, Dopp JC, Ding M, Griscavage J, Ignarro LJ, Lowenstein CJ. PMID: 9169863.

View in: PubMed Mentions: 14 Fields:
Neu Neurology
Translation:Animals Cells
Differential expression, cytokine modulation, and specific functions of type-1 and type-2 tumor necrosis factor receptors in rat glia. J Neuroimmunol. 1997 May; 75(1-2):104-12. Dopp JM, Mackenzie-Graham A, Otero GC, Merrill JE. PMID: 9143243.

View in: PubMed Mentions: 76 Fields:
All Allergy and Immunology Neu Neurology
Translation:Humans Animals Cells
Gender differences in autoimmune demyelination in the mouse: implications for multiple sclerosis. Ann Neurol. 1996 Jun; 39(6):724-33. Voskuhl RR, Pitchekian-Halabi H, MacKenzie-Graham A, McFarland HF, Raine CS. PMID: 8651644.

View in: PubMed Mentions: 36 Fields:
Neu Neurology
Translation:Humans Animals Cells
The role of nitric oxide in glial pathology. Ann N Y Acad Sci. 1994 Nov 17; 738:436-46. Mitrovic B, St Pierre BA, Mackenzie-Graham AJ, Merrill JE. PMID: 7832453.

View in: PubMed Mentions: 3 Fields:
Sci Science
Translation:Humans Animals Cells
Differential sensitivity to nitric oxide in immortalized, cloned murine oligodendrocyte cell lines. Dev Neurosci. 1994; 16(3-4):162-71. Mackenzie-Graham AJ, Mitrovic B, Smoll A, Merrill JE. PMID: 7535681.

View in: PubMed Mentions: 5 Fields:
Neu Neurology
Translation:Animals Cells