Gerald S Lipshutz

Title(s)Professor-in-Residence, Surgery
SchoolMedicine
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    Other Positions
    Title(s)Professor-in-Residence, Molecular and Medical Pharmacology

    Title(s)Professor-in-Residence, Urology

    Title(s)Professor-in-Residence, Psychiatry and Biobehavioral Sciences


    Collapse Research 
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    Elucidation of the Role of the Arginase Isoforms in Normal Neuronal Development and Function
    NIH R03NS114623Feb 15, 2020 - Jan 31, 2022
    Role: Principal Investigator
    A pluripotent stem cell platform for exploring the cause and mechanism of neuronal dysfunction in arginase deficiency
    NIH R21NS114820Feb 15, 2020 - Jan 31, 2022
    Role: Principal Investigator
    Understanding the Mechanism and Preventing the Unique Neuropathology of Arginase Deficiency
    NIH R01NS110596Apr 15, 2019 - Dec 31, 2023
    Role: Principal Investigator
    Cell and Gene Replacement Strategies for Arginase Deficiency
    NIH R01NS100979Apr 1, 2017 - Feb 28, 2022
    Role: Principal Investigator
    Investigation of Neuroanatomical Alterations in Arginase Deficiency After Neonatal Gene Therapy
    NIH R03NS101682Mar 15, 2017 - Feb 29, 2020
    Role: Principal Investigator
    Development of Molecular Therapy for Carbamoyl Phosphate Synthetase Deficiency
    NIH R21NS091654Feb 1, 2015 - Jan 31, 2018
    Role: Principal Investigator
    Immunologic Aspects of In Utero or Neonatal AAV-Based Gene Therapy
    NIH R56AI108826Sep 1, 2014 - May 31, 2017
    Role: Principal Investigator
    Pathophysiology and Gene Replacement Strategies for Arginase Deficiency
    NIH R01NS071076Sep 17, 2010 - Jul 31, 2016
    Role: Principal Investigator
    The Immune Response to Viral Vector and Transgenes in the Fetus
    NIH K08HD057555Sep 27, 2007 - Aug 31, 2013
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Targeted deletion of PAC1 receptors in retinal neurons enhances neuron loss and axonopathy in a model of multiple sclerosis and optic neuritis. Neurobiol Dis. 2021 Oct 02; 160:105524. Van C, Condro MC, Ko HH, Hoang AQ, Zhu R, Lov K, Ricaflanca PT, Diep AL, Nguyen NNM, Lipshutz GS, MacKenzie-Graham A, Waschek JA. PMID: 34610465.
      View in: PubMed   Mentions:    Fields:    
    2. CPS1: Looking at an ancient enzyme in a modern light. Mol Genet Metab. 2020 11; 131(3):289-298. Nitzahn M, Lipshutz GS. PMID: 33317798.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    3. Split AAV-Mediated Gene Therapy Restores Ureagenesis in a Murine Model of Carbamoyl Phosphate Synthetase 1 Deficiency. Mol Ther. 2020 07 08; 28(7):1717-1730. Nitzahn M, Allegri G, Khoja S, Truong B, Makris G, Häberle J, Lipshutz GS. PMID: 32359471.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    4. Lipid nanoparticle-targeted mRNA therapy as a treatment for the inherited metabolic liver disorder arginase deficiency. Proc Natl Acad Sci U S A. 2019 10 15; 116(42):21150-21159. Truong B, Allegri G, Liu XB, Burke KE, Zhu X, Cederbaum SD, Häberle J, Martini PGV, Lipshutz GS. PMID: 31501335.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    5. Factors predicting kidney delayed graft function among recipients of simultaneous liver-kidney transplantation: A single-center experience. Clin Transplant. 2019 06; 33(6):e13569. Korayem IM, Agopian VG, Lunsford KE, Gritsch HA, Veale JL, Lipshutz GS, Yersiz H, Serrone CL, Kaldas FM, Farmer DG, Bunnapradist S, Danovitch GM, Busuttil RW, Zarrinpar A. PMID: 31006141.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. A constitutive knockout of murine carbamoyl phosphate synthetase 1 results in death with marked hyperglutaminemia and hyperammonemia. J Inherit Metab Dis. 2019 11; 42(6):1044-1053. Khoja S, Nitzahn M, Truong B, Lambert J, Willis B, Allegri G, Rüfenacht V, Häberle J, Lipshutz GS. PMID: 30835861.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    7. Human hepatocyte transplantation corrects the inherited metabolic liver disorder arginase deficiency in mice. Mol Genet Metab. 2018 06; 124(2):114-123. Angarita SAK, Truong B, Khoja S, Nitzahn M, Rajbhandari AK, Zhuravka I, Duarte S, Lin MG, Lam AK, Cederbaum SD, Lipshutz GS. PMID: 29724658.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    8. Conditional disruption of hepatic carbamoyl phosphate synthetase 1 in mice results in hyperammonemia without orotic aciduria and can be corrected by liver-directed gene therapy. Mol Genet Metab. 2018 08; 124(4):243-253. Khoja S, Nitzahn M, Hermann K, Truong B, Borzone R, Willis B, Rudd M, Palmer DJ, Ng P, Brunetti-Pierri N, Lipshutz GS. PMID: 29801986.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    9. Biopsy-proven Hepatocellular Carcinoma in a 53-year-old Woman With Arginase Deficiency. Pediatr Dev Pathol. 2017 Nov-Dec; 20(6):517-521. Koo M, Lipshutz GS, Cederbaum SD, Lassman C. PMID: 29187023.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    10. Restoring Ureagenesis in Hepatocytes by CRISPR/Cas9-mediated Genomic Addition to Arginase-deficient Induced Pluripotent Stem Cells. Mol Ther Nucleic Acids. 2016 Nov 29; 5(11):e394. Lee PC, Truong B, Vega-Crespo A, Gilmore WB, Hermann K, Angarita SA, Tang JK, Chang KM, Wininger AE, Lam AK, Schoenberg BE, Cederbaum SD, Pyle AD, Byrne JA, Lipshutz GS. PMID: 27898091.
      View in: PubMed   Mentions:
    11. New priorities: Analysis of the New Kidney Allocation System on UCLA patients transplanted from the deceased donor waitlist. Hum Immunol. 2017 Jan; 78(1):41-48. Hickey MJ, Zheng Y, Valenzuela N, Zhang Q, Krystal C, Lum E, Tsai EW, Lipshutz GS, Gritsch HA, Danovitch G, Veale J, Gjertson D, Cecka M, Reed EF. PMID: 27818166.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    12. Functional Human and Murine Tissue-Engineered Liver Is Generated from Adult Stem/Progenitor Cells. Stem Cells Transl Med. 2017 01; 6(1):238-248. Mavila N, Trecartin A, Spurrier R, Xiao Y, Hou X, James D, Fu X, Truong B, Wang C, Lipshutz GS, Wang KS, Grikscheit TC. PMID: 28170183.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    13. Investigating the functionality of an OCT4-short response element in human induced pluripotent stem cells. Mol Ther Methods Clin Dev. 2016; 3:16050. Vega-Crespo A, Truong B, Hermann KJ, Awe JP, Chang KM, Lee PC, Schoenberg BE, Wu L, Byrne JA, Lipshutz GS. PMID: 27500178.
      View in: PubMed   Mentions:
    14. Augmentation of transgene-encoded protein after neonatal injection of adeno-associated virus improves hepatic copy number without immune responses. Pediatr Res. 2015 Sep; 78(3):239-246. Tai DS, Hu C, Kim EH, Lipshutz GS. PMID: 26042522.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    15. Optimizing HLA matching in a highly sensitized pediatric patient using ABO-incompatible and paired exchange kidney transplantation. Pediatr Nephrol. 2015 May; 30(5):855-8. Nayak AB, Ettenger RB, McGuire S, Lipshutz GS, Reed EF, Veale J, Tsai EW. PMID: 25750074.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    16. Autologous islet transplantation with remote islet isolation after pancreas resection for chronic pancreatitis. JAMA Surg. 2015 Feb; 150(2):118-24. Tai DS, Shen N, Szot GL, Posselt A, Feduska NJ, Habashy A, Clerkin B, Core E, Busuttil RW, Hines OJ, Reber HA, Lipshutz GS. PMID: 25494212.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    17. Myocyte-mediated arginase expression controls hyperargininemia but not hyperammonemia in arginase-deficient mice. Mol Ther. 2014 Oct; 22(10):1792-802. Hu C, Kasten J, Park H, Bhargava R, Tai DS, Grody WW, Nguyen QG, Hauschka SD, Cederbaum SD, Lipshutz GS. PMID: 24888478.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    18. Lethal phenotype in conditional late-onset arginase 1 deficiency in the mouse. Mol Genet Metab. 2013 Nov; 110(3):222-30. Kasten J, Hu C, Bhargava R, Park H, Tai D, Byrne JA, Marescau B, De Deyn PP, Schlichting L, Grody WW, Cederbaum SD, Lipshutz GS. PMID: 23920045.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    19. Kidney paired donation in the presence of donor-specific antibodies. Kidney Int. 2013 Nov; 84(5):1009-16. Blumberg JM, Gritsch HA, Reed EF, Cecka JM, Lipshutz GS, Danovitch GM, McGuire S, Gjertson DW, Veale JL. PMID: 23715120.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    20. Low rates of short- and long-term graft loss after kidney-pancreas transplant from a single center. JAMA Surg. 2013 Apr; 148(4):368-73. Tai DS, Hong J, Busuttil RW, Lipshutz GS. PMID: 23715937.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    21. Long-term survival of the juvenile lethal arginase-deficient mouse with AAV gene therapy. Mol Ther. 2012 Oct; 20(10):1844-51. Lee EK, Hu C, Bhargava R, Rozengurt N, Stout D, Grody WW, Cederbaum SD, Lipshutz GS. PMID: 22760543.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    22. Improvement in short-term pancreas transplant outcome by targeted antimicrobial therapy and refined donor selection. Am Surg. 2011 Oct; 77(10):1407-11. Schnickel GT, Busuttil RW, Lipshutz GS. PMID: 22127100.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    23. Liver transplantation using organ donation after cardiac death: a clinical predictive index for graft failure-free survival. Arch Surg. 2011 Sep; 146(9):1017-23. Hong JC, Yersiz H, Kositamongkol P, Xia VW, Kaldas FM, Petrowsky H, Farmer DG, Lipshutz G, Markovic D, Hiatt JR, Busuttil RW. PMID: 21930997.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    24. ABO blood type-incompatible kidney transplantation and access to organs. Arch Surg. 2011 Apr; 146(4):453-8. Lipshutz GS, McGuire S, Zhu Q, Ziman A, Davis R, Goldfinger D, Reed EF, Wilkinson AH, Danovitch GM, Pham PT. PMID: 21502455.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    25. Neonatal helper-dependent adenoviral vector gene therapy mediates correction of hemophilia A and tolerance to human factor VIII. Proc Natl Acad Sci U S A. 2011 Feb 01; 108(5):2082-7. Hu C, Cela RG, Suzuki M, Lee B, Lipshutz GS. PMID: 21245323.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    26. RH10 provides superior transgene expression in mice when compared with natural AAV serotypes for neonatal gene therapy. J Gene Med. 2010 Sep; 12(9):766-78. Hu C, Busuttil RW, Lipshutz GS. PMID: 20821747.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    27. YSPSL (rPSGL-Ig) for improvement of early renal allograft function: a double-blind, placebo-controlled, multi-center Phase IIa study. Clin Transplant. 2011 Jul-Aug; 25(4):523-33. Gaber AO, Mulgaonkar S, Kahan BD, Woodle ES, Alloway R, Bajjoka I, Jensik S, Klintmalm GB, Patton PR, Wiseman A, Lipshutz G, Kupiec-Weglinski J, Gaber LW, Katz E, Irish W, Squiers EC, Hemmerich S. PMID: 20573162.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCTClinical Trials
    28. The evolving role of alemtuzumab (Campath-1H) in renal transplantation. Drug Des Devel Ther. 2009 Sep 21; 3:41-9. Pham PT, Lipshutz GS, Pham PT, Kawahji J, Singer JS, Pham PC. PMID: 19920920.
      View in: PubMed   Mentions: 2     Fields:    
    29. Short-term correction of arginase deficiency in a neonatal murine model with a helper-dependent adenoviral vector. Mol Ther. 2009 Jul; 17(7):1155-63. Gau CL, Rosenblatt RA, Cerullo V, Lay FD, Dow AC, Livesay J, Brunetti-Pierri N, Lee B, Cederbaum SD, Grody WW, Lipshutz GS. PMID: 19367256.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    30. Death from metastatic donor-derived ovarian cancer in a male kidney transplant recipient. Am J Transplant. 2009 Feb; 9(2):428-32. Lipshutz GS, Mihara N, Wong R, Wallace WD, Allen-Auerbach M, Dorigo O, Rao PN, Pham PC, Pham PT. PMID: 19178417.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    31. Transplant tourism in the United States: a single-center experience. Clin J Am Soc Nephrol. 2008 Nov; 3(6):1820-8. Gill J, Madhira BR, Gjertson D, Lipshutz G, Cecka JM, Pham PT, Wilkinson A, Bunnapradist S, Danovitch GM. PMID: 18922987.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    32. CMV otitis: a rare presentation in an adult transplant recipient. Transplantation. 2008 Jun 27; 85(12):1870-71. Lipshutz GS, Dow AC, Pham PC, Pham PT. PMID: 18580487.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    33. Evaluation of gene promoters for liver expression by hydrodynamic gene transfer. J Surg Res. 2008 Jul; 148(1):60-6. Nguyen AT, Dow AC, Kupiec-Weglinski J, Busuttil RW, Lipshutz GS. PMID: 18570932.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    34. Thrombotic microangiopathy following pancreas after kidney transplants. Clin Transplant. 2008 Mar-Apr; 22(2):236-41. Lipshutz GS, Pham PC, Ghobrial MR, Wallace WD, Miller JM, Pham PT. PMID: 18339145.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    35. Outcomes of dual adult kidney transplants in the United States: an analysis of the OPTN/UNOS database. Transplantation. 2008 Jan 15; 85(1):62-8. Gill J, Cho YW, Danovitch GM, Wilkinson A, Lipshutz G, Pham PT, Gill JS, Shah T, Bunnapradist S. PMID: 18192913.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    36. New onset diabetes mellitus after solid organ transplantation. Endocrinol Metab Clin North Am. 2007 Dec; 36(4):873-90; vii. Pham PT, Pham PC, Lipshutz GS, Wilkinson AH. PMID: 17983926.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    37. Pancreas-kidney and pancreas transplantation for the treatment of diabetes mellitus. Endocrinol Metab Clin North Am. 2007 Dec; 36(4):1015-38; x. Lipshutz GS, Wilkinson AH. PMID: 17983934.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    38. Liver transplantation for HELLP syndrome. Am Surg. 2007 Oct; 73(10):1013-6. Zarrinpar A, Farmer DG, Ghobrial RM, Lipshutz GS, Gu Y, Hiatt JR, Busuttil RW. PMID: 17983071.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    39. Liver transplantation in those of advancing age: the case for transplantation. Liver Transpl. 2007 Oct; 13(10):1355-7. Lipshutz GS, Busuttil RW. PMID: 17902139.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    40. Liver transplantation criteria for hepatocellular carcinoma should be expanded: a 22-year experience with 467 patients at UCLA. Ann Surg. 2007 Sep; 246(3):502-9; discussion 509-11. Duffy JP, Vardanian A, Benjamin E, Watson M, Farmer DG, Ghobrial RM, Lipshutz G, Yersiz H, Lu DS, Lassman C, Tong MJ, Hiatt JR, Busuttil RW. PMID: 17717454.
      View in: PubMed   Mentions: 113     Fields:    Translation:Humans
    41. Outcome of liver transplantation in septuagenarians: a single-center experience. Arch Surg. 2007 Aug; 142(8):775-81; discussion 781-4. Lipshutz GS, Hiatt J, Ghobrial RM, Farmer DG, Martinez MM, Yersiz H, Gornbein J, Busuttil RW. PMID: 17709732.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    42. Portocaval hemitransposition in pediatric liver transplant recipients: a single-center experience. Liver Transpl. 2006 Jul; 12(7):1097-103. Lipshutz GS, Patel S, Hiatt JR, Yersiz H, Farmer DG, McDiarmid SV, Ghobrial RM, Busuttil RW. PMID: 16799947.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    43. Optimal utilization of donor grafts with extended criteria: a single-center experience in over 1000 liver transplants. Ann Surg. 2006 Jun; 243(6):748-53; discussion 753-5. Cameron AM, Ghobrial RM, Yersiz H, Farmer DG, Lipshutz GS, Gordon SA, Zimmerman M, Hong J, Collins TE, Gornbein J, Amersi F, Weaver M, Cao C, Chen T, Hiatt JR, Busuttil RW. PMID: 16772778.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    44. Gene therapy in liver ischemia and reperfusion injury. Curr Pharm Des. 2006; 12(23):2969-75. Ke B, Lipshutz GS, Kupiec-Weglinski JW. PMID: 16918425.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    45. Analysis of long-term outcomes of 3200 liver transplantations over two decades: a single-center experience. Ann Surg. 2005 Jun; 241(6):905-16; discussion 916-8. Busuttil RW, Farmer DG, Yersiz H, Hiatt JR, McDiarmid SV, Goldstein LI, Saab S, Han S, Durazo F, Weaver M, Cao C, Chen T, Lipshutz GS, Holt C, Gordon S, Gornbein J, Amersi F, Ghobrial RM. PMID: 15912040.
      View in: PubMed   Mentions: 69     Fields:    Translation:Humans
    46. BKV in simultaneous pancreas-kidney transplant recipients: a leading cause of renal graft loss in first 2 years post-transplant. Am J Transplant. 2005 Feb; 5(2):366-73. Lipshutz GS, Mahanty H, Feng S, Hirose R, Stock PG, Kang SM, Posselt AM, Freise CE. PMID: 15643997.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    47. BK nephropathy in kidney transplant recipients treated with a calcineurin inhibitor-free immunosuppression regimen. Am J Transplant. 2004 Dec; 4(12):2132-4. Lipshutz GS, Flechner SM, Govani MV, Vincenti F. PMID: 15575919.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    48. Death from donor-transmitted malignancy despite emergency liver retransplantation. Liver Transpl. 2003 Oct; 9(10):1102-7. Lipshutz GS, Baxter-Lowe LA, Nguyen T, Jones KD, Ascher NL, Feng S. PMID: 14526407.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
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