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Lipshutz Gerald

Title(s)Member, CTSI
SchoolCTSI
Phone310-267-3590
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    Other Positions
    Title(s)Professor In-Residence, Surgery

    Title(s)Professor In-Residence, Endocrinology Diabetes and Hypertension

    Title(s)Professor In-Residence, Molecular & Medical Pharmacology

    Title(s)Member, Liver Transplantation

    Title(s)Member, Molecular Pharmacology GPB Home Area

    Title(s)Member, Pfleger Liver Institute

    Title(s)Member, Tumor Immunology Program at the Jonsson Comprehensive Cancer Center (JCCC)


    Collapse Research 
    Collapse Research Activities and Funding
    Understanding the Mechanism and Preventing the Unique Neuropathology of Arginase Deficiency
    NIH/NINDS R01NS110596Apr 15, 2019 - Dec 31, 2023
    Role: Principal Investigator
    Cell and Gene Replacement Strategies for Arginase Deficiency
    NIH/NINDS R01NS100979Apr 1, 2017 - Feb 28, 2022
    Role: Principal Investigator
    Investigation of Neuroanatomical Alterations in Arginase Deficiency After Neonatal Gene Therapy
    NIH/NINDS R03NS101682Mar 15, 2017 - Feb 28, 2019
    Role: Principal Investigator
    Development of Molecular Therapy for Carbamoyl Phosphate Synthetase Deficiency
    NIH/NINDS R21NS091654Feb 1, 2015 - Jan 31, 2017
    Role: Principal Investigator
    Immunologic Aspects of In Utero or Neonatal AAV-Based Gene Therapy
    NIH/NIAID R56AI108826Sep 1, 2014 - Aug 31, 2015
    Role: Principal Investigator
    Pathophysiology and Gene Replacement Strategies for Arginase Deficiency
    NIH/NINDS R01NS071076Sep 17, 2010 - Jul 31, 2015
    Role: Principal Investigator
    The Immune Response to Viral Vector and Transgenes in the Fetus
    NIH/NICHD K08HD057555Sep 27, 2007 - Aug 31, 2013
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Truong B, Allegri G, Liu XB, Burke KE, Zhu X, Cederbaum SD, Häberle J, Martini PGV, Lipshutz GS. Lipid nanoparticle-targeted mRNA therapy as a treatment for the inherited metabolic liver disorder arginase deficiency. Proc Natl Acad Sci U S A. 2019 Oct 15; 116(42):21150-21159. PMID: 31501335.
      View in: PubMed
    2. Liu XB, Haney JR, Cantero G, Lambert JR, Otero-Garcia M, Truong B, Gropman A, Cobos I, Cederbaum SD, Lipshutz GS. Hepatic arginase deficiency fosters dysmyelination during postnatal CNS development. JCI Insight. 2019 Sep 05; 4(17). PMID: 31484827.
      View in: PubMed
    3. Korayem IM, Agopian VG, Lunsford KE, Gritsch HA, Veale JL, Lipshutz GS, Yersiz H, Serrone CL, Kaldas FM, Farmer DG, Bunnapradist S, Danovitch GM, Busuttil RW, Zarrinpar A. Factors predicting kidney delayed graft function among recipients of simultaneous liver-kidney transplantation: A single-center experience. Clin Transplant. 2019 Jun; 33(6):e13569. PMID: 31006141.
      View in: PubMed
    4. Soria LR, Nitzahn M, De Angelis A, Khoja S, Attanasio S, Annunziata P, Palmer DJ, Ng P, Lipshutz GS, Brunetti-Pierri N. Hepatic glutamine synthetase augmentation enhances ammonia detoxification. J Inherit Metab Dis. 2019 Nov; 42(6):1128-1135. PMID: 30724386.
      View in: PubMed
    5. Khoja S, Nitzahn M, Truong B, Lambert J, Willis B, Allegri G, Rüfenacht V, Häberle J, Lipshutz GS. A constitutive knockout of murine carbamoyl phosphate synthetase 1 results in death with marked hyperglutaminemia and hyperammonemia. J Inherit Metab Dis. 2019 Nov; 42(6):1044-1053. PMID: 30835861.
      View in: PubMed
    6. Angarita SAK, Truong B, Khoja S, Nitzahn M, Rajbhandari AK, Zhuravka I, Duarte S, Lin MG, Lam AK, Cederbaum SD, Lipshutz GS. Human hepatocyte transplantation corrects the inherited metabolic liver disorder arginase deficiency in mice. Mol Genet Metab. 2018 06; 124(2):114-123. PMID: 29724658.
      View in: PubMed
    7. Khoja S, Nitzahn M, Hermann K, Truong B, Borzone R, Willis B, Rudd M, Palmer DJ, Ng P, Brunetti-Pierri N, Lipshutz GS. Conditional disruption of hepatic carbamoyl phosphate synthetase 1 in mice results in hyperammonemia without orotic aciduria and can be corrected by liver-directed gene therapy. Mol Genet Metab. 2018 08; 124(4):243-253. PMID: 29801986.
      View in: PubMed
    8. Salas JR, Chen BY, Wong A, Duarte S, Angarita SAK, Lipshutz GS, Witte ON, Clark PM. Noninvasive Imaging of Drug-Induced Liver Injury with 18F-DFA PET. J Nucl Med. 2018 08; 59(8):1308-1315. PMID: 29496991.
      View in: PubMed
    9. Koo M, Lipshutz GS, Cederbaum SD, Lassman C. Biopsy-proven Hepatocellular Carcinoma in a 53-year-old Woman With Arginase Deficiency. Pediatr Dev Pathol. 2017 Nov-Dec; 20(6):517-521. PMID: 29187023.
      View in: PubMed
    10. Lee PC, Truong B, Vega-Crespo A, Gilmore WB, Hermann K, Angarita SA, Tang JK, Chang KM, Wininger AE, Lam AK, Schoenberg BE, Cederbaum SD, Pyle AD, Byrne JA, Lipshutz GS. Restoring Ureagenesis in Hepatocytes by CRISPR/Cas9-mediated Genomic Addition to Arginase-deficient Induced Pluripotent Stem Cells. Mol Ther Nucleic Acids. 2016 Nov 29; 5(11):e394. PMID: 27898091.
      View in: PubMed
    11. Hickey MJ, Zheng Y, Valenzuela N, Zhang Q, Krystal C, Lum E, Tsai EW, Lipshutz GS, Gritsch HA, Danovitch G, Veale J, Gjertson D, Cecka M, Reed EF. New priorities: Analysis of the New Kidney Allocation System on UCLA patients transplanted from the deceased donor waitlist. Hum Immunol. 2017 Jan; 78(1):41-48. PMID: 27818166.
      View in: PubMed
    12. Mavila N, Trecartin A, Spurrier R, Xiao Y, Hou X, James D, Fu X, Truong B, Wang C, Lipshutz GS, Wang KS, Grikscheit TC. Functional Human and Murine Tissue-Engineered Liver Is Generated from Adult Stem/Progenitor Cells. Stem Cells Transl Med. 2017 01; 6(1):238-248. PMID: 28170183.
      View in: PubMed
    13. Vega-Crespo A, Truong B, Hermann KJ, Awe JP, Chang KM, Lee PC, Schoenberg BE, Wu L, Byrne JA, Lipshutz GS. Investigating the functionality of an OCT4-short response element in human induced pluripotent stem cells. Mol Ther Methods Clin Dev. 2016; 3:16050. PMID: 27500178.
      View in: PubMed
    14. Cantero G, Liu XB, Mervis RF, Lazaro MT, Cederbaum SD, Golshani P, Lipshutz GS. Rescue of the Functional Alterations of Motor Cortical Circuits in Arginase Deficiency by Neonatal Gene Therapy. J Neurosci. 2016 06 22; 36(25):6680-90. PMID: 27335400.
      View in: PubMed
    15. Liu Y, Du J, Choi JS, Chen KJ, Hou S, Yan M, Lin WY, Chen KS, Ro T, Lipshutz GS, Wu L, Shi L, Lu Y, Tseng HR, Wang H. A High-Throughput Platform for Formulating and Screening Multifunctional Nanoparticles Capable of Simultaneous Delivery of Genes and Transcription Factors. Angew Chem Int Ed Engl. 2016 Jan 04; 55(1):169-73. PMID: 26768819.
      View in: PubMed
    16. Tai DS, Hu C, Kim EH, Lipshutz GS. Augmentation of transgene-encoded protein after neonatal injection of adeno-associated virus improves hepatic copy number without immune responses. Pediatr Res. 2015 Sep; 78(3):239-246. PMID: 26042522.
      View in: PubMed
    17. Nayak AB, Ettenger RB, McGuire S, Lipshutz GS, Reed EF, Veale J, Tsai EW. Optimizing HLA matching in a highly sensitized pediatric patient using ABO-incompatible and paired exchange kidney transplantation. Pediatr Nephrol. 2015 May; 30(5):855-8. PMID: 25750074.
      View in: PubMed
    18. Tai DS, Shen N, Szot GL, Posselt A, Feduska NJ, Habashy A, Clerkin B, Core E, Busuttil RW, Hines OJ, Reber HA, Lipshutz GS. Autologous islet transplantation with remote islet isolation after pancreas resection for chronic pancreatitis. JAMA Surg. 2015 Feb; 150(2):118-24. PMID: 25494212.
      View in: PubMed
    19. Hu C, Kasten J, Park H, Bhargava R, Tai DS, Grody WW, Nguyen QG, Hauschka SD, Cederbaum SD, Lipshutz GS. Myocyte-mediated arginase expression controls hyperargininemia but not hyperammonemia in arginase-deficient mice. Mol Ther. 2014 Oct; 22(10):1792-802. PMID: 24888478.
      View in: PubMed
    20. Awe JP, Lee PC, Ramathal C, Vega-Crespo A, Durruthy-Durruthy J, Cooper A, Karumbayaram S, Lowry WE, Clark AT, Zack JA, Sebastiano V, Kohn DB, Pyle AD, Martin MG, Lipshutz GS, Phelps PE, Pera RA, Byrne JA. Generation and characterization of transgene-free human induced pluripotent stem cells and conversion to putative clinical-grade status. Stem Cell Res Ther. 2013 Jul 26; 4(4):87. PMID: 23890092.
      View in: PubMed
    21. Kasten J, Hu C, Bhargava R, Park H, Tai D, Byrne JA, Marescau B, De Deyn PP, Schlichting L, Grody WW, Cederbaum SD, Lipshutz GS. Lethal phenotype in conditional late-onset arginase 1 deficiency in the mouse. Mol Genet Metab. 2013 Nov; 110(3):222-30. PMID: 23920045.
      View in: PubMed
    22. Blumberg JM, Gritsch HA, Reed EF, Cecka JM, Lipshutz GS, Danovitch GM, McGuire S, Gjertson DW, Veale JL. Kidney paired donation in the presence of donor-specific antibodies. Kidney Int. 2013 Nov; 84(5):1009-16. PMID: 23715120.
      View in: PubMed
    23. Tai DS, Hong J, Busuttil RW, Lipshutz GS. Low rates of short- and long-term graft loss after kidney-pancreas transplant from a single center. JAMA Surg. 2013 Apr; 148(4):368-73. PMID: 23715937.
      View in: PubMed
    24. Lee EK, Hu C, Bhargava R, Rozengurt N, Stout D, Grody WW, Cederbaum SD, Lipshutz GS. Long-term survival of the juvenile lethal arginase-deficient mouse with AAV gene therapy. Mol Ther. 2012 Oct; 20(10):1844-51. PMID: 22760543.
      View in: PubMed
    25. Schnickel GT, Busuttil RW, Lipshutz GS. Improvement in short-term pancreas transplant outcome by targeted antimicrobial therapy and refined donor selection. Am Surg. 2011 Oct; 77(10):1407-11. PMID: 22127100.
      View in: PubMed
    26. Hong JC, Yersiz H, Kositamongkol P, Xia VW, Kaldas FM, Petrowsky H, Farmer DG, Lipshutz G, Markovic D, Hiatt JR, Busuttil RW. Liver transplantation using organ donation after cardiac death: a clinical predictive index for graft failure-free survival. Arch Surg. 2011 Sep; 146(9):1017-23. PMID: 21930997.
      View in: PubMed
    27. Lipshutz GS, McGuire S, Zhu Q, Ziman A, Davis R, Goldfinger D, Reed EF, Wilkinson AH, Danovitch GM, Pham PT. ABO blood type-incompatible kidney transplantation and access to organs. Arch Surg. 2011 Apr; 146(4):453-8. PMID: 21502455.
      View in: PubMed
    28. Hu C, Cela RG, Suzuki M, Lee B, Lipshutz GS. Neonatal helper-dependent adenoviral vector gene therapy mediates correction of hemophilia A and tolerance to human factor VIII. Proc Natl Acad Sci U S A. 2011 Feb 01; 108(5):2082-7. PMID: 21245323.
      View in: PubMed
    29. Hu C, Busuttil RW, Lipshutz GS. RH10 provides superior transgene expression in mice when compared with natural AAV serotypes for neonatal gene therapy. J Gene Med. 2010 Sep; 12(9):766-78. PMID: 20821747.
      View in: PubMed
    30. Gaber AO, Mulgaonkar S, Kahan BD, Woodle ES, Alloway R, Bajjoka I, Jensik S, Klintmalm GB, Patton PR, Wiseman A, Lipshutz G, Kupiec-Weglinski J, Gaber LW, Katz E, Irish W, Squiers EC, Hemmerich S. YSPSL (rPSGL-Ig) for improvement of early renal allograft function: a double-blind, placebo-controlled, multi-center Phase IIa study. Clin Transplant. 2011 Jul-Aug; 25(4):523-33. PMID: 20573162.
      View in: PubMed
    31. Pham PT, Lipshutz GS, Pham PT, Kawahji J, Singer JS, Pham PC. The evolving role of alemtuzumab (Campath-1H) in renal transplantation. Drug Des Devel Ther. 2009 Sep 21; 3:41-9. PMID: 19920920.
      View in: PubMed
    32. Gau CL, Rosenblatt RA, Cerullo V, Lay FD, Dow AC, Livesay J, Brunetti-Pierri N, Lee B, Cederbaum SD, Grody WW, Lipshutz GS. Short-term correction of arginase deficiency in a neonatal murine model with a helper-dependent adenoviral vector. Mol Ther. 2009 Jul; 17(7):1155-63. PMID: 19367256.
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    33. Lipshutz GS, Mihara N, Wong R, Wallace WD, Allen-Auerbach M, Dorigo O, Rao PN, Pham PC, Pham PT. Death from metastatic donor-derived ovarian cancer in a male kidney transplant recipient. Am J Transplant. 2009 Feb; 9(2):428-32. PMID: 19178417.
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    34. Gill J, Madhira BR, Gjertson D, Lipshutz G, Cecka JM, Pham PT, Wilkinson A, Bunnapradist S, Danovitch GM. Transplant tourism in the United States: a single-center experience. Clin J Am Soc Nephrol. 2008 Nov; 3(6):1820-8. PMID: 18922987.
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    35. Lipshutz GS, Dow AC, Pham PC, Pham PT. CMV otitis: a rare presentation in an adult transplant recipient. Transplantation. 2008 Jun 27; 85(12):1870-71. PMID: 18580487.
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    36. Nguyen AT, Dow AC, Kupiec-Weglinski J, Busuttil RW, Lipshutz GS. Evaluation of gene promoters for liver expression by hydrodynamic gene transfer. J Surg Res. 2008 Jul; 148(1):60-6. PMID: 18570932.
      View in: PubMed
    37. Lipshutz GS, Pham PC, Ghobrial MR, Wallace WD, Miller JM, Pham PT. Thrombotic microangiopathy following pancreas after kidney transplants. Clin Transplant. 2008 Mar-Apr; 22(2):236-41. PMID: 18339145.
      View in: PubMed
    38. Gill J, Cho YW, Danovitch GM, Wilkinson A, Lipshutz G, Pham PT, Gill JS, Shah T, Bunnapradist S. Outcomes of dual adult kidney transplants in the United States: an analysis of the OPTN/UNOS database. Transplantation. 2008 Jan 15; 85(1):62-8. PMID: 18192913.
      View in: PubMed
    39. Pham PT, Pham PC, Lipshutz GS, Wilkinson AH. New onset diabetes mellitus after solid organ transplantation. Endocrinol Metab Clin North Am. 2007 Dec; 36(4):873-90; vii. PMID: 17983926.
      View in: PubMed
    40. Lipshutz GS, Wilkinson AH. Pancreas-kidney and pancreas transplantation for the treatment of diabetes mellitus. Endocrinol Metab Clin North Am. 2007 Dec; 36(4):1015-38; x. PMID: 17983934.
      View in: PubMed
    41. Mahanty HD, Posselt AM, Lipshutz GS, Schneider DB, Freise CE. Catheter-directed therapy for DVT after pancreas transplantation. Clin Transplant. 2007 Nov-Dec; 21(6):748-54. PMID: 17988269.
      View in: PubMed
    42. Zarrinpar A, Farmer DG, Ghobrial RM, Lipshutz GS, Gu Y, Hiatt JR, Busuttil RW. Liver transplantation for HELLP syndrome. Am Surg. 2007 Oct; 73(10):1013-6. PMID: 17983071.
      View in: PubMed
    43. Lipshutz GS, Busuttil RW. Liver transplantation in those of advancing age: the case for transplantation. Liver Transpl. 2007 Oct; 13(10):1355-7. PMID: 17902139.
      View in: PubMed
    44. Duffy JP, Vardanian A, Benjamin E, Watson M, Farmer DG, Ghobrial RM, Lipshutz G, Yersiz H, Lu DS, Lassman C, Tong MJ, Hiatt JR, Busuttil RW. Liver transplantation criteria for hepatocellular carcinoma should be expanded: a 22-year experience with 467 patients at UCLA. Ann Surg. 2007 Sep; 246(3):502-9; discussion 509-11. PMID: 17717454.
      View in: PubMed
    45. Lipshutz GS, Hiatt J, Ghobrial RM, Farmer DG, Martinez MM, Yersiz H, Gornbein J, Busuttil RW. Outcome of liver transplantation in septuagenarians: a single-center experience. Arch Surg. 2007 Aug; 142(8):775-81; discussion 781-4. PMID: 17709732.
      View in: PubMed
    46. Lipshutz GS, Patel S, Hiatt JR, Yersiz H, Farmer DG, McDiarmid SV, Ghobrial RM, Busuttil RW. Portocaval hemitransposition in pediatric liver transplant recipients: a single-center experience. Liver Transpl. 2006 Jul; 12(7):1097-103. PMID: 16799947.
      View in: PubMed
    47. Cameron AM, Ghobrial RM, Yersiz H, Farmer DG, Lipshutz GS, Gordon SA, Zimmerman M, Hong J, Collins TE, Gornbein J, Amersi F, Weaver M, Cao C, Chen T, Hiatt JR, Busuttil RW. Optimal utilization of donor grafts with extended criteria: a single-center experience in over 1000 liver transplants. Ann Surg. 2006 Jun; 243(6):748-53; discussion 753-5. PMID: 16772778.
      View in: PubMed
    48. Ke B, Lipshutz GS, Kupiec-Weglinski JW. Gene therapy in liver ischemia and reperfusion injury. Curr Pharm Des. 2006; 12(23):2969-75. PMID: 16918425.
      View in: PubMed
    49. Busuttil RW, Farmer DG, Yersiz H, Hiatt JR, McDiarmid SV, Goldstein LI, Saab S, Han S, Durazo F, Weaver M, Cao C, Chen T, Lipshutz GS, Holt C, Gordon S, Gornbein J, Amersi F, Ghobrial RM. Analysis of long-term outcomes of 3200 liver transplantations over two decades: a single-center experience. Ann Surg. 2005 Jun; 241(6):905-16; discussion 916-8. PMID: 15912040.
      View in: PubMed
    50. Lipshutz GS, Mahanty H, Feng S, Hirose R, Stock PG, Kang SM, Posselt AM, Freise CE. BKV in simultaneous pancreas-kidney transplant recipients: a leading cause of renal graft loss in first 2 years post-transplant. Am J Transplant. 2005 Feb; 5(2):366-73. PMID: 15643997.
      View in: PubMed
    51. Lipshutz GS, Flechner SM, Govani MV, Vincenti F. BK nephropathy in kidney transplant recipients treated with a calcineurin inhibitor-free immunosuppression regimen. Am J Transplant. 2004 Dec; 4(12):2132-4. PMID: 15575919.
      View in: PubMed
    52. Lipshutz GS, Baxter-Lowe LA, Nguyen T, Jones KD, Ascher NL, Feng S. Death from donor-transmitted malignancy despite emergency liver retransplantation. Liver Transpl. 2003 Oct; 9(10):1102-7. PMID: 14526407.
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    53. Brennan TV, Lipshutz GS, Posselt AM, Horn JK. Congenital cleft spleen with CT scan appearance of high-grade splenic laceration after blunt abdominal trauma. J Emerg Med. 2003 Aug; 25(2):139-42. PMID: 12901998.
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    54. Lipshutz GS, Titre D, Brindle M, Bisconte AR, Contag CH, Gaensler KM. Comparison of gene expression after intraperitoneal delivery of AAV2 or AAV5 in utero. Mol Ther. 2003 Jul; 8(1):90-8. PMID: 12842432.
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    55. Lipshutz GS, Brennan TV, Warren RS. Thorotrast-induced liver neoplasia: a collective review. J Am Coll Surg. 2002 Nov; 195(5):713-8. PMID: 12437262.
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    56. Brennan TV, Lipshutz GS, Gibbs VC, Norton JA. Total mesenteric excision in the treatment of rectal carcinoma: methods and outcomes. Surg Oncol. 2002 May; 10(4):171-6. PMID: 12020671.
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