Gal Bitan

Title(s)Professor-in-Residence, Neurology
SchoolMedicine
ORCID ORCID Icon0000-0001-7046-3754 Additional info
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    Collapse Biography 
    Collapse Education and Training
    The Hebrew University of Jerusalem, IsraelPhD04/1996Organic Chemistry
    Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MAPostdoc09/1999Structural Biology and protein Biochemistry
    Brigham and Women's Hospital/Harvard Medical School, Boston, MAPostdoc03/2003Protein folding and assembly
    Collapse Awards and Honors
    UCLA2005Turken Award for Alzheimer’s Disease Research
    UCLA2018Inaugural Undergraduate Faculty Mentor Award
    The MSA Coalition2021Invited Keynote Speaker of Annual Symposium
    American Society for Mass Spectrometry2021Invited Plenary Lecture Asilomar Conference on Neurodegenerative Diseases

    Collapse Overview 
    Collapse Overview
    Gal Bitan got his PhD in organic chemistry from the Hebrew University of Jerusalem, Israel. During his postdoc at Brigham and Women's Hospital/Harvard Medical School, Boston, MA, Dr. Bitan worked on pathologic self-assembly of amyloid ß-protein (Aß) and made fundamental contributions to the study of early events in the pathologic cascades that cause Alzheimer's disease, including the discovery of one of the earliest oligomers in the assembly cascade, the paranucleus. In 2004, Dr. Bitan joined UCLA where he is currently a Professor of Neurology. His research program combines basic and translational research focused on neurodegenerative proteinopathies, including Alzheimer's disease, other tauopathies, Parkinson's disease, and atypical parkinsonian disorders.
    The Bitan group has discovered small molecules called "molecular tweezers" that are broad-spectrum inhibitors of abnormal protein oligomerization and aggregation. A lead compound, CLR01, was shown to ameliorate disease phenotype and reduce toxic protein aggregates in pre-clinical models of Alzheimer's disease, Parkinson's disease, multiple system atrophy, amyotrophic lateral sclerosis, transthyretin amyloidosis, and desmin-related cardiomyopathy.
    In a different line of research, the group has been developing biomarkers in CNS-originating extracellular vesicles and has shown that such biomarkers can distinguish between Parkinson's disease and multiple system atrophy with high sensitivity and specificity using a simple blood test.
    The Bitan group is also the first to discover exophers in mammalian neurons. Exophers are new cellular compartments/extracellular vesicles previously described in C. elegans, which are thought to participate in non-cell-autonomous clearance of dysfunctional organelles and protein aggregates, in addition to other, currently unknown roles in neurophysiology.
    Collapse Websites

    Collapse Research 
    Collapse Research Activities and Funding
    Investigation of the effect of structural modifications of tau on assembly state and seeding
    NIH/NIA R01AG054000Jul 15, 2017 - May 31, 2022
    Role: Principal Investigator
    Misfolded protein clearance enhancers for Alzheimers therapy
    NIH R01AG050721Sep 15, 2015 - Apr 30, 2021
    Role: Principal Investigator
    Novel Specific Ligands for ABeta Oligomers
    NIH R21AG030709Sep 1, 2007 - May 31, 2010
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Novel avenues of tau research. Alzheimers Dement. 2024 Mar; 20(3):2240-2261. Sexton CE, Bitan G, Bowles KR, Brys M, Buée L, Maina MB, Clelland CD, Cohen AD, Crary JF, Dage JL, Diaz K, Frost B, Gan L, Goate AM, Golbe LI, Hansson O, Karch CM, Kolb HC, La Joie R, Lee SE, Matallana D, Miller BL, Onyike CU, Quiroz YT, Rexach JE, Rohrer JD, Rommel A, Sadri-Vakili G, Schindler SE, Schneider JA, Sperling RA, Teunissen CE, Weninger SC, Worley SL, Zheng H, Carrillo MC. PMID: 38170841; PMCID: PMC10984447.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    2. Recent advances and future therapy development for Alzheimer's disease and related disorders. Neural Regen Res. 2024 Sep 01; 19(9):1877-1878. Hong M, Bitan G. PMID: 38227506.
      View in: PubMed   Mentions:
    3. Characterization of Molecular Tweezer Binding on α-Synuclein with Native Top-Down Mass Spectrometry and Ion Mobility-Mass Spectrometry Reveals a Mechanism for Aggregation Inhibition. J Am Soc Mass Spectrom. 2023 Dec 06; 34(12):2739-2747. Lantz C, Lopez J, Goring AK, Zenaidee MA, Biggs K, Whitelegge JP, Ogorzalek Loo RR, Klärner FG, Schrader T, Bitan G, Loo JA. PMID: 37936057; PMCID: PMC10959575.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. IM-MS and ECD-MS/MS Provide Insight into Modulation of Amyloid Proteins Self-Assembly by Peptides and Small Molecules. J Am Soc Mass Spectrom. 2023 Oct 04; 34(10):2066-2086. Taha HB, Chawla E, Bitan G. PMID: 37607351.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    5. Biomarkers for parkinsonian disorders in CNS-originating EVs: promise and challenges. Acta Neuropathol. 2023 05; 145(5):515-540. Dutta S, Hornung S, Taha HB, Bitan G. PMID: 37012443; PMCID: PMC10071251.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    6. Toward a biomarker panel measured in CNS-originating extracellular vesicles for improved differential diagnosis of Parkinson's disease and multiple system atrophy. Transl Neurodegener. 2023 03 20; 12(1):14. Taha HB, Hornung S, Dutta S, Fenwick L, Lahgui O, Howe K, Elabed N, Del Rosario I, Wong DY, Duarte Folle A, Markovic D, Palma JA, Kang UJ, Alcalay RN, Sklerov M, Kaufmann H, Fogel BL, Bronstein JM, Ritz B, Bitan G. PMID: 36935518; PMCID: PMC10026428.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    7. Development of a Novel Electrochemiluminescence ELISA for Quantification of α-Synuclein Phosphorylated at Ser129 in Biological Samples. ACS Chem Neurosci. 2023 04 05; 14(7):1238-1248. Dutta S, Hornung S, Taha HB, Biggs K, Siddique I, Chamoun LM, Shahpasand-Kroner H, Lantz C, Herrera-Vaquero M, Stefanova N, Loo JA, Bitan G. PMID: 36920792; PMCID: PMC10080651.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    8. Editorial: Trends in biomarkers for neurodegenerative diseases: Current research and future perspectives. Front Aging Neurosci. 2023; 15:1153932. Dutta S, Sklerov M, Teunissen CE, Bitan G. PMID: 36875706; PMCID: PMC9978689.
      View in: PubMed   Mentions:
    9. Using FRET-Based Biosensor Cells to Study the Seeding Activity of Tau and α-Synuclein. Methods Mol Biol. 2023; 2551:125-145. Maina KN, Smet-Nocca C, Bitan G. PMID: 36310201; PMCID: PMC9836052.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    10. Molecular Tweezers: Supramolecular Hosts with Broad-Spectrum Biological Applications. Pharmacol Rev. 2023 03; 75(2):263-308. Shahpasand-Kroner H, Siddique I, Malik R, Linares GR, Ivanova MI, Ichida J, Weil T, Münch J, Sanchez-Garcia E, Klärner FG, Schrader T, Bitan G. PMID: 36549866; PMCID: PMC9976797.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    11. The Amyloid Inhibitor CLR01 Relieves Autophagy and Ameliorates Neuropathology in a Severe Lysosomal Storage Disease. Mol Ther. 2022 Nov 02; 30(11):3499. Monaco A, Maffia V, Sorrentino NC, Sambri I, Ezhova Y, Giuliano T, Cacace V, Nusco E, De Risi M, De Leonibus E, Schrader T, Klärner FG, Bitan G, Fraldi A. PMID: 36261045; PMCID: PMC9637752.
      View in: PubMed   Mentions:    Fields:    
    12. A minute fraction of α-synuclein in extracellular vesicles may be a major contributor to α-synuclein spreading following autophagy inhibition. Front Mol Neurosci. 2022; 15:1001382. Taha HB, Kearney B, Bitan G. PMID: 36245921; PMCID: PMC9554483.
      View in: PubMed   Mentions: 1  
    13. Editorial: Exosomes: Message in a vesicle. Front Pharmacol. 2022; 13:1018928. Dutta S, Nimse SB, Van Keuren-Jensen K, Bitan G. PMID: 36160457; PMCID: PMC9494591.
      View in: PubMed   Mentions: 1  
    14. mTOR Inhibition with Sirolimus in Multiple System Atrophy: A Randomized, Double-Blind, Placebo-Controlled Futility Trial and 1-Year Biomarker Longitudinal Analysis. Mov Disord. 2022 04; 37(4):778-789. Palma JA, Martinez J, Millar Vernetti P, Ma T, Perez MA, Zhong J, Qian Y, Dutta S, Maina KN, Siddique I, Bitan G, Ades-Aron B, Shepherd TM, Kang UJ, Kaufmann H. PMID: 35040506; PMCID: PMC9018525.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    15. Three-repeat and four-repeat tau isoforms form different oligomers. Protein Sci. 2022 03; 31(3):613-627. Shahpasand-Kroner H, Portillo J, Lantz C, Seidler PM, Sarafian N, Loo JA, Bitan G. PMID: 34902187; PMCID: PMC8862439.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    16. Aptamers targeting amyloidogenic proteins and their emerging role in neurodegenerative diseases. J Biol Chem. 2022 01; 298(1):101478. Murakami K, Izuo N, Bitan G. PMID: 34896392; PMCID: PMC8728582.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    17. Lysine-selective molecular tweezers are cell penetrant and concentrate in lysosomes. Commun Biol. 2021 09 14; 4(1):1076. Li Z, Siddique I, Hadrovic I, Kirupakaran A, Li J, Zhang Y, Klärner FG, Schrader T, Bitan G. PMID: 34521989; PMCID: PMC8440717.
      View in: PubMed   Mentions: 4  Translation:HumansAnimalsCells
    18. α-Synuclein in blood exosomes immunoprecipitated using neuronal and oligodendroglial markers distinguishes Parkinson's disease from multiple system atrophy. Acta Neuropathol. 2021 09; 142(3):495-511. Dutta S, Hornung S, Kruayatidee A, Maina KN, Del Rosario I, Paul KC, Wong DY, Duarte Folle A, Markovic D, Palma JA, Serrano GE, Adler CH, Perlman SL, Poon WW, Kang UJ, Alcalay RN, Sklerov M, Gylys KH, Kaufmann H, Fogel BL, Bronstein JM, Ritz B, Bitan G. PMID: 33991233; PMCID: PMC8357708.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    19. Inhibition of Staphylococcus aureus biofilm-forming functional amyloid by molecular tweezers. Cell Chem Biol. 2021 09 16; 28(9):1310-1320.e5. Malishev R, Salinas N, Gibson J, Eden AB, Mieres-Perez J, Ruiz-Blanco YB, Malka O, Kolusheva S, Klärner FG, Schrader T, Sanchez-Garcia E, Wang C, Landau M, Bitan G, Jelinek R. PMID: 33852903; PMCID: PMC9377279.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    20. The molecular tweezer CLR01 improves behavioral deficits and reduces tau pathology in P301S-tau transgenic mice. Alzheimers Res Ther. 2021 01 04; 13(1):6. Di J, Siddique I, Li Z, Malki G, Hornung S, Dutta S, Hurst I, Ishaaya E, Wang A, Tu S, Boghos A, Ericsson I, Klärner FG, Schrader T, Bitan G. PMID: 33397489; PMCID: PMC7784007.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    21. Supramolecular Mechanism of Viral Envelope Disruption by Molecular Tweezers. J Am Chem Soc. 2020 10 07; 142(40):17024-17038. Weil T, Groß R, Röcker A, Bravo-Rodriguez K, Heid C, Sowislok A, Le MH, Erwin N, Dwivedi M, Bart SM, Bates P, Wettstein L, Müller JA, Harms M, Sparrer K, Ruiz-Blanco YB, Stürzel CM, von Einem J, Lippold S, Read C, Walther P, Hebel M, Kreppel F, Klärner FG, Bitan G, Ehrmann M, Weil T, Winter R, Schrader T, Shorter J, Sanchez-Garcia E, Münch J. PMID: 32926779; PMCID: PMC7523239.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    22. CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson's disease. Nat Commun. 2020 09 28; 11(1):4885. Bengoa-Vergniory N, Faggiani E, Ramos-Gonzalez P, Kirkiz E, Connor-Robson N, Brown LV, Siddique I, Li Z, Vingill S, Cioroch M, Cavaliere F, Threlfell S, Roberts B, Schrader T, Klärner FG, Cragg S, Dehay B, Bitan G, Matute C, Bezard E, Wade-Martins R. PMID: 32985503; PMCID: PMC7522721.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    23. Examination of SOD1 aggregation modulators and their effect on SOD1 enzymatic activity as a proxy for potential toxicity. FASEB J. 2020 09; 34(9):11957-11969. Malik R, Corrales C, Linsenmeier M, Alalami H, Sepanj N, Bitan G. PMID: 32701214; PMCID: PMC7903925.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    24. Different Inhibitors of Aβ42-Induced Toxicity Have Distinct Metal-Ion Dependency. ACS Chem Neurosci. 2020 08 05; 11(15):2243-2255. Mason AJ, Hurst I, Malik R, Siddique I, Solomonov I, Sagi I, Klärner FG, Schrader T, Bitan G. PMID: 32559370; PMCID: PMC7695034.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    25. The recent failure of the PROMESA clinical trial for multiple system atrophy raises the question-are polyphenols a viable therapeutic option against proteinopathies? Ann Transl Med. 2020 Jun; 8(11):719. Bitan G. PMID: 32617339; PMCID: PMC7327354.
      View in: PubMed   Mentions: 4  
    26. CNS-Derived Blood Exosomes as a Promising Source of Biomarkers: Opportunities and Challenges. Front Mol Neurosci. 2020; 13:38. Hornung S, Dutta S, Bitan G. PMID: 32265650; PMCID: PMC7096580.
      View in: PubMed   Mentions: 87  
    27. The Amyloid Inhibitor CLR01 Relieves Autophagy and Ameliorates Neuropathology in a Severe Lysosomal Storage Disease. Mol Ther. 2020 04 08; 28(4):1167-1176. Monaco A, Maffia V, Sorrentino NC, Sambri I, Ezhova Y, Giuliano T, Cacace V, Nusco E, De Risi M, De Leonibus E, Schrader T, Klärner FG, Bitan G, Fraldi A. PMID: 32087148; PMCID: PMC7132627.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    28. Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation. Alzheimers Res Ther. 2019 10 18; 11(1):86. Shin WS, Di J, Cao Q, Li B, Seidler PM, Murray KA, Bitan G, Jiang L. PMID: 31627745; PMCID: PMC6800506.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    29. Molecular Lysine Tweezers Counteract Aberrant Protein Aggregation. Front Chem. 2019; 7:657. Hadrovic I, Rebmann P, Klärner FG, Bitan G, Schrader T. PMID: 31632951; PMCID: PMC6779714.
      View in: PubMed   Mentions: 10  
    30. Ischemic axonal injury up-regulates MARK4 in cortical neurons and primes tau phosphorylation and aggregation. Acta Neuropathol Commun. 2019 08 20; 7(1):135. Hayden EY, Putman J, Nunez S, Shin WS, Oberoi M, Charreton M, Dutta S, Li Z, Komuro Y, Joy MT, Bitan G, MacKenzie-Graham A, Jiang L, Hinman JD. PMID: 31429800; PMCID: PMC6700776.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    31. Disease-modifying therapy for proteinopathies: Can the exception become the rule? Prog Mol Biol Transl Sci. 2019; 168:277-287. Bitan G. PMID: 31699321; PMCID: PMC7032046.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    32. The molecular tweezer CLR01 reduces aggregated, pathologic, and seeding-competent α-synuclein in experimental multiple system atrophy. Biochim Biophys Acta Mol Basis Dis. 2019 11 01; 1865(11):165513. Herrera-Vaquero M, Bouquio D, Kallab M, Biggs K, Nair G, Ochoa J, Heras-Garvin A, Heid C, Hadrovic I, Poewe W, Wenning GK, Klärner FG, Schrader T, Bitan G, Stefanova N. PMID: 31319154; PMCID: PMC8425273.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    33. Major Differences between the Self-Assembly and Seeding Behavior of Heparin-Induced and in Vitro Phosphorylated Tau and Their Modulation by Potential Inhibitors. ACS Chem Biol. 2019 06 21; 14(6):1363-1379. Despres C, Di J, Cantrelle FX, Li Z, Huvent I, Chambraud B, Zhao J, Chen J, Chen S, Lippens G, Zhang F, Linhardt R, Wang C, Klärner FG, Schrader T, Landrieu I, Bitan G, Smet-Nocca C. PMID: 31046227; PMCID: PMC6636790.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    34. A Label-Free Platform for Identification of Exosomes from Different Sources. ACS Sens. 2019 02 22; 4(2):488-497. Yan Z, Dutta S, Liu Z, Yu X, Mesgarzadeh N, Ji F, Bitan G, Xie YH. PMID: 30644736.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    35. The molecular tweezer CLR01 inhibits aberrant superoxide dismutase 1 (SOD1) self-assembly in vitro and in the G93A-SOD1 mouse model of ALS. J Biol Chem. 2019 03 08; 294(10):3501-3513. Malik R, Meng H, Wongkongkathep P, Corrales CI, Sepanj N, Atlasi RS, Klärner FG, Schrader T, Spencer MJ, Loo JA, Wiedau M, Bitan G. PMID: 30602569; PMCID: PMC6416427.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    36. Investigation of Anti-SOD1 Antibodies Yields New Structural Insight into SOD1 Misfolding and Surprising Behavior of the Antibodies Themselves. ACS Chem Biol. 2018 09 21; 13(9):2794-2807. Atlasi RS, Malik R, Corrales CI, Tzeplaeff L, Whitelegge JP, Cashman NR, Bitan G. PMID: 30110532; PMCID: PMC6475120.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    37. Native Top-Down Mass Spectrometry and Ion Mobility Spectrometry of the Interaction of Tau Protein with a Molecular Tweezer Assembly Modulator. J Am Soc Mass Spectrom. 2019 Jan; 30(1):16-23. Nshanian M, Lantz C, Wongkongkathep P, Schrader T, Klärner FG, Blümke A, Despres C, Ehrmann M, Smet-Nocca C, Bitan G, Loo JA. PMID: 30062477; PMCID: PMC6320309.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    38. The molecular tweezer CLR01 inhibits Ebola and Zika virus infection. Antiviral Res. 2018 04; 152:26-35. Röcker AE, Müller JA, Dietzel E, Harms M, Krüger F, Heid C, Sowislok A, Riber CF, Kupke A, Lippold S, von Einem J, Beer J, Knöll B, Becker S, Schmidt-Chanasit J, Otto M, Vapalahti O, Zelikin AN, Bitan G, Schrader T, Münch J. PMID: 29428508; PMCID: PMC7113745.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    39. Using Molecular Tweezers to Remodel Abnormal Protein Self-Assembly and Inhibit the Toxicity of Amyloidogenic Proteins. Methods Mol Biol. 2018; 1777:369-386. Malik R, Di J, Nair G, Attar A, Taylor K, Teng E, Klärner FG, Schrader T, Bitan G. PMID: 29744849; PMCID: PMC6459406.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    40. Preparation of Pure Populations of Amyloid β-Protein Oligomers of Defined Size. Methods Mol Biol. 2018; 1779:3-12. Hayden EY, Conovaloff JL, Mason A, Bitan G, Teplow DB. PMID: 29886523; PMCID: PMC6490168.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    41. Recommendations of the Global Multiple System Atrophy Research Roadmap Meeting. Neurology. 2018 01 09; 90(2):74-82. Walsh RR, Krismer F, Galpern WR, Wenning GK, Low PA, Halliday G, Koroshetz WJ, Holton J, Quinn NP, Rascol O, Shaw LM, Eidelberg D, Bower P, Cummings JL, Abler V, Biedenharn J, Bitan G, Brooks DJ, Brundin P, Fernandez H, Fortier P, Freeman R, Gasser T, Hewitt A, Höglinger GU, Huentelman MJ, Jensen PH, Jeromin A, Kang UJ, Kaufmann H, Kellerman L, Khurana V, Klockgether T, Kim WS, Langer C, LeWitt P, Masliah E, Meissner W, Melki R, Ostrowitzki S, Piantadosi S, Poewe W, Robertson D, Roemer C, Schenk D, Schlossmacher M, Schmahmann JD, Seppi K, Shih L, Siderowf A, Stebbins GT, Stefanova N, Tsuji S, Sutton S, Zhang J. PMID: 29237794; PMCID: PMC5772155.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    42. A Molecular Tweezer Ameliorates Motor Deficits in Mice Overexpressing α-Synuclein. Neurotherapeutics. 2017 Oct; 14(4):1107-1119. Richter F, Subramaniam SR, Magen I, Lee P, Hayes J, Attar A, Zhu C, Franich NR, Bove N, De La Rosa K, Kwong J, Klärner FG, Schrader T, Chesselet MF, Bitan G. PMID: 28585223; PMCID: PMC5722755.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    43. Inhibition of Mutant αB Crystallin-Induced Protein Aggregation by a Molecular Tweezer. J Am Heart Assoc. 2017 Aug 08; 6(8). Xu N, Bitan G, Schrader T, Klärner FG, Osinska H, Robbins J. PMID: 28862927; PMCID: PMC5586456.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    44. Inhibition of Huntingtin Exon-1 Aggregation by the Molecular Tweezer CLR01. J Am Chem Soc. 2017 04 26; 139(16):5640-5643. Vöpel T, Bravo-Rodriguez K, Mittal S, Vachharajani S, Gnutt D, Sharma A, Steinhof A, Fatoba O, Ellrichmann G, Nshanian M, Heid C, Loo JA, Klärner FG, Schrader T, Bitan G, Wanker EE, Ebbinghaus S, Sanchez-Garcia E. PMID: 28406616; PMCID: PMC5506490.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    45. Computational On-Chip Imaging of Nanoparticles and Biomolecules using Ultraviolet Light. Sci Rep. 2017 03 09; 7:44157. Daloglu MU, Ray A, Gorocs Z, Xiong M, Malik R, Bitan G, McLeod E, Ozcan A. PMID: 28276489; PMCID: PMC5343455.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    46. Preparation of pure populations of covalently stabilized amyloid β-protein oligomers of specific sizes. Anal Biochem. 2017 Feb 01; 518:78-85. Hayden EY, Conovaloff JL, Mason A, Bitan G, Teplow DB. PMID: 27810329; PMCID: PMC5474095.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    47. Molecular tweezers for lysine and arginine - powerful inhibitors of pathologic protein aggregation. Chem Commun (Camb). 2016 Oct 15; 52(76):11318-34. Schrader T, Bitan G, Klärner FG. PMID: 27546596; PMCID: PMC5026632.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimals
    48. Modulation of Amyloid β-Protein (Aβ) Assembly by Homologous C-Terminal Fragments as a Strategy for Inhibiting Aβ Toxicity. ACS Chem Neurosci. 2016 07 20; 7(7):845-56. Li H, Rahimi F, Bitan G. PMID: 27322435; PMCID: PMC5450937.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    49. Neurotoxicity of the Parkinson Disease-Associated Pesticide Ziram Is Synuclein-Dependent in Zebrafish Embryos. Environ Health Perspect. 2016 Nov; 124(11):1766-1775. Lulla A, Barnhill L, Bitan G, Ivanova MI, Nguyen B, O'Donnell K, Stahl MC, Yamashiro C, Klärner FG, Schrader T, Sagasti A, Bronstein JM. PMID: 27301718; PMCID: PMC5089875.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    50. Reducing synuclein accumulation improves neuronal survival after spinal cord injury. Exp Neurol. 2016 Apr; 278:105-15. Fogerson SM, van Brummen AJ, Busch DJ, Allen SR, Roychaudhuri R, Banks SM, Klärner FG, Schrader T, Bitan G, Morgan JR. PMID: 26854933; PMCID: PMC4788542.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    51. Role of Species-Specific Primary Structure Differences in Aβ42 Assembly and Neurotoxicity. ACS Chem Neurosci. 2015 Dec 16; 6(12):1941-55. Roychaudhuri R, Zheng X, Lomakin A, Maiti P, Condron MM, Benedek GB, Bitan G, Bowers MT, Teplow DB. PMID: 26421877; PMCID: PMC4844016.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    52. Mechanism of C-Terminal Fragments of Amyloid β-Protein as Aβ Inhibitors: Do C-Terminal Interactions Play a Key Role in Their Inhibitory Activity? J Phys Chem B. 2016 Mar 03; 120(8):1615-23. Zheng X, Wu C, Liu D, Li H, Bitan G, Shea JE, Bowers MT. PMID: 26439281; PMCID: PMC4777659.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    53. Toxicity inhibitors protect lipid membranes from disruption by Aβ42. ACS Chem Neurosci. 2015 Nov 18; 6(11):1860-9. Malishev R, Nandi S, Kolusheva S, Levi-Kalisman Y, Klärner FG, Schrader T, Bitan G, Jelinek R. PMID: 26317327.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    54. A molecular tweezer antagonizes seminal amyloids and HIV infection. Elife. 2015 Aug 18; 4. Lump E, Castellano LM, Meier C, Seeliger J, Erwin N, Sperlich B, Stürzel CM, Usmani S, Hammond RM, von Einem J, Gerold G, Kreppel F, Bravo-Rodriguez K, Pietschmann T, Holmes VM, Palesch D, Zirafi O, Weissman D, Sowislok A, Wettig B, Heid C, Kirchhoff F, Weil T, Klärner FG, Schrader T, Bitan G, Sanchez-Garcia E, Winter R, Shorter J, Münch J. PMID: 26284498; PMCID: PMC4536748.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansPHPublic Health
    55. The Lys-Specific Molecular Tweezer, CLR01, Modulates Aggregation of the Mutant p53 DNA Binding Domain and Inhibits Its Toxicity. Biochemistry. 2015 Jun 23; 54(24):3729-38. Herzog G, Shmueli MD, Levy L, Engel L, Gazit E, Klärner FG, Schrader T, Bitan G, Segal D. PMID: 26030124.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    56. Molecular tweezers inhibit islet amyloid polypeptide assembly and toxicity by a new mechanism. ACS Chem Biol. 2015 Jun 19; 10(6):1555-69. Lopes DH, Attar A, Nair G, Hayden EY, Du Z, McDaniel K, Dutt S, Bravo-Rodriguez K, Mittal S, Klärner FG, Wang C, Sanchez-Garcia E, Schrader T, Bitan G. PMID: 25844890.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    57. Amyloid β-protein assembly: The effect of molecular tweezers CLR01 and CLR03. J Phys Chem B. 2015 Apr 09; 119(14):4831-41. Zheng X, Liu D, Klärner FG, Schrader T, Bitan G, Bowers MT. PMID: 25751170; PMCID: PMC4415044.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
    58. Exact modeling of cylindrical metal-dielectric multilayers beyond the effective medium approximation. Opt Lett. 2014 Nov 15; 39(22):6517-20. Aronovich D, Bitan G, Bartal G. PMID: 25490508.
      View in: PubMed   Mentions:    Fields:    
    59. Safety and pharmacological characterization of the molecular tweezer CLR01 - a broad-spectrum inhibitor of amyloid proteins' toxicity. BMC Pharmacol Toxicol. 2014 Apr 16; 15:23. Attar A, Chan WT, Klärner FG, Schrader T, Bitan G. PMID: 24735982; PMCID: PMC3996151.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    60. Molecular tweezers targeting transthyretin amyloidosis. Neurotherapeutics. 2014 Apr; 11(2):450-61. Ferreira N, Pereira-Henriques A, Attar A, Klärner FG, Schrader T, Bitan G, Gales L, Saraiva MJ, Almeida MR. PMID: 24459092; PMCID: PMC3996111.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    61. Molecular basis for preventing α-synuclein aggregation by a molecular tweezer. J Biol Chem. 2014 Apr 11; 289(15):10727-10737. Acharya S, Safaie BM, Wongkongkathep P, Ivanova MI, Attar A, Klärner FG, Schrader T, Loo JA, Bitan G, Lapidus LJ. PMID: 24567327; PMCID: PMC4036189.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    62. Disrupting self-assembly and toxicity of amyloidogenic protein oligomers by "molecular tweezers" - from the test tube to animal models. Curr Pharm Des. 2014; 20(15):2469-83. Attar A, Bitan G. PMID: 23859557; PMCID: PMC4261945.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    63. A shortened Barnes maze protocol reveals memory deficits at 4-months of age in the triple-transgenic mouse model of Alzheimer's disease. PLoS One. 2013; 8(11):e80355. Attar A, Liu T, Chan WT, Hayes J, Nejad M, Lei K, Bitan G. PMID: 24236177; PMCID: PMC3827415.
      View in: PubMed   Mentions: 66     Fields:    Translation:Animals
    64. Tranilast binds to aβ monomers and promotes aβ fibrillation. Biochemistry. 2013 Jun 11; 52(23):3995-4002. Connors CR, Rosenman DJ, Lopes DH, Mittal S, Bitan G, Sorci M, Belfort G, Garcia A, Wang C. PMID: 23679559; PMCID: PMC4082028.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    65. Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers. Brain. 2012 Dec; 135(Pt 12):3735-48. Attar A, Ripoli C, Riccardi E, Maiti P, Li Puma DD, Liu T, Hayes J, Jones MR, Lichti-Kaiser K, Yang F, Gale GD, Tseng CH, Tan M, Xie CW, Straudinger JL, Klärner FG, Schrader T, Frautschy SA, Grassi C, Bitan G. PMID: 23183235; PMCID: PMC3525056.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    66. Effects of different amyloid β-protein analogues on synaptic function. Neurobiol Aging. 2013 Apr; 34(4):1032-44. Ripoli C, Piacentini R, Riccardi E, Leone L, Li Puma DD, Bitan G, Grassi C. PMID: 23046860.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    67. Plasma methionine sulfoxide in persons with familial Alzheimer's disease mutations. Dement Geriatr Cogn Disord. 2012; 33(4):219-25. Ringman JM, Fithian AT, Gylys K, Cummings JL, Coppola G, Elashoff D, Pratico D, Moskovitz J, Bitan G. PMID: 22584618; PMCID: PMC3568669.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    68. Zn2+-Aβ40 complexes form metastable quasi-spherical oligomers that are cytotoxic to cultured hippocampal neurons. J Biol Chem. 2012 Jun 08; 287(24):20555-64. Solomonov I, Korkotian E, Born B, Feldman Y, Bitler A, Rahimi F, Li H, Bitan G, Sagi I. PMID: 22528492; PMCID: PMC3370240.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    69. A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo. Neurotherapeutics. 2012 Apr; 9(2):464-76. Prabhudesai S, Sinha S, Attar A, Kotagiri A, Fitzmaurice AG, Lakshmanan R, Lakshmanan R, Ivanova MI, Loo JA, Klärner FG, Schrader T, Stahl M, Bitan G, Bronstein JM. PMID: 22373667; PMCID: PMC3337029.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    70. A key role for lysine residues in amyloid β-protein folding, assembly, and toxicity. ACS Chem Neurosci. 2012 Jun 20; 3(6):473-81. Sinha S, Lopes DH, Bitan G. PMID: 22860216; PMCID: PMC3382451.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    71. Design of β-amyloid aggregation inhibitors from a predicted structural motif. J Med Chem. 2012 Apr 12; 55(7):3002-10. Novick PA, Lopes DH, Branson KM, Esteras-Chopo A, Graef IA, Bitan G, Pande VS. PMID: 22420626; PMCID: PMC3766731.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    72. Comparison of three amyloid assembly inhibitors: the sugar scyllo-inositol, the polyphenol epigallocatechin gallate, and the molecular tweezer CLR01. ACS Chem Neurosci. 2012 Jun 20; 3(6):451-8. Sinha S, Du Z, Maiti P, Klärner FG, Schrader T, Wang C, Bitan G. PMID: 22860214; PMCID: PMC3386858.
      View in: PubMed   Mentions: 49     Fields:    Translation:Animals
    73. Modulating self-assembly of amyloidogenic proteins as a therapeutic approach for neurodegenerative diseases: strategies and mechanisms. ChemMedChem. 2012 Mar 05; 7(3):359-74. Liu T, Bitan G. PMID: 22323134.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    74. A two-step strategy for structure-activity relationship studies of N-methylated aβ42 C-terminal fragments as aβ42 toxicity inhibitors. ChemMedChem. 2012 Mar 05; 7(3):515-22. Li H, Zemel R, Lopes DH, Monien BH, Bitan G. PMID: 22307963; PMCID: PMC3517043.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    75. Application of photochemical cross-linking to the study of oligomerization of amyloidogenic proteins. Methods Mol Biol. 2012; 849:11-21. Lopes DH, Sinha S, Rosensweig C, Bitan G. PMID: 22528080.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    76. Preparation of stable amyloid β-protein oligomers of defined assembly order. Methods Mol Biol. 2012; 849:23-31. Rosensweig C, Ono K, Murakami K, Lowenstein DK, Bitan G, Teplow DB. PMID: 22528081; PMCID: PMC5767166.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    77. Aβ(39-42) modulates Aβ oligomerization but not fibril formation. Biochemistry. 2012 Jan 10; 51(1):108-17. Gessel MM, Wu C, Li H, Bitan G, Shea JE, Bowers MT. PMID: 22129303; PMCID: PMC3271797.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    78. C-terminal tetrapeptides inhibit Aβ42-induced neurotoxicity primarily through specific interaction at the N-terminus of Aβ42. J Med Chem. 2011 Dec 22; 54(24):8451-60. Li H, Du Z, Lopes DH, Fradinger EA, Wang C, Bitan G. PMID: 22087474; PMCID: PMC3240737.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    79. Induction of methionine-sulfoxide reductases protects neurons from amyloid β-protein insults in vitro and in vivo. Biochemistry. 2011 Dec 13; 50(49):10687-97. Moskovitz J, Maiti P, Lopes DH, Oien DB, Attar A, Liu T, Mittal S, Hayes J, Bitan G. PMID: 22059533; PMCID: PMC3235361.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    80. Lysine-specific molecular tweezers are broad-spectrum inhibitors of assembly and toxicity of amyloid proteins. J Am Chem Soc. 2011 Oct 26; 133(42):16958-69. Sinha S, Lopes DH, Du Z, Pang ES, Shanmugam A, Lomakin A, Talbiersky P, Tennstaedt A, McDaniel K, Bakshi R, Kuo PY, Ehrmann M, Benedek GB, Loo JA, Klärner FG, Schrader T, Wang C, Bitan G. PMID: 21916458; PMCID: PMC3210512.
      View in: PubMed   Mentions: 105     Fields:    Translation:AnimalsCells
    81. Structural basis for Aβ1–42 toxicity inhibition by Aβ C-terminal fragments: discrete molecular dynamics study. J Mol Biol. 2011 Jul 08; 410(2):316-28. Urbanc B, Betnel M, Cruz L, Li H, Fradinger EA, Monien BH, Bitan G. PMID: 21621545; PMCID: PMC3124842.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    82. Rational design of β-sheet ligands against Aβ42-induced toxicity. J Am Chem Soc. 2011 Mar 30; 133(12):4348-58. Hochdörffer K, März-Berberich J, Nagel-Steger L, Epple M, Meyer-Zaika W, Horn AH, Sticht H, Sinha S, Bitan G, Schrader T. PMID: 21381732.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    83. Surprising toxicity and assembly behaviour of amyloid β-protein oxidized to sulfone. Biochem J. 2011 Jan 15; 433(2):323-32. Maiti P, Piacentini R, Ripoli C, Grassi C, Bitan G. PMID: 21044048; PMCID: PMC5767168.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    84. Mechanistic investigation of the inhibition of Abeta42 assembly and neurotoxicity by Abeta42 C-terminal fragments. Biochemistry. 2010 Aug 03; 49(30):6358-64. Li H, Monien BH, Lomakin A, Zemel R, Fradinger EA, Tan M, Spring SM, Urbanc B, Xie CW, Benedek GB, Bitan G. PMID: 20568734; PMCID: PMC2912417.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    85. Selection of aptamers for amyloid beta-protein, the causative agent of Alzheimer's disease. J Vis Exp. 2010 May 13; (39). Rahimi F, Bitan G. PMID: 20616783; PMCID: PMC2918391.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    86. Elucidation of amyloid beta-protein oligomerization mechanisms: discrete molecular dynamics study. J Am Chem Soc. 2010 Mar 31; 132(12):4266-80. Urbanc B, Betnel M, Cruz L, Bitan G, Teplow DB. PMID: 20218566; PMCID: PMC5767167.
      View in: PubMed   Mentions: 85     Fields:    Translation:Cells
    87. Despite its role in assembly, methionine 35 is not necessary for amyloid beta-protein toxicity. J Neurochem. 2010 Jun; 113(5):1252-62. Maiti P, Lomakin A, Benedek GB, Bitan G. PMID: 20345758; PMCID: PMC2908238.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    88. Biophysical characterization of Abeta42 C-terminal fragments: inhibitors of Abeta42 neurotoxicity. Biochemistry. 2010 Feb 16; 49(6):1259-67. Li H, Monien BH, Fradinger EA, Urbanc B, Bitan G. PMID: 20050679; PMCID: PMC2831638.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    89. RNA aptamers generated against oligomeric Abeta40 recognize common amyloid aptatopes with low specificity but high sensitivity. PLoS One. 2009 Nov 10; 4(11):e7694. Rahimi F, Murakami K, Summers JL, Chen CH, Bitan G. PMID: 19901993; PMCID: PMC2770325.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    90. Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease. Nat Chem. 2009 Jul; 1(4):326-31. Bernstein SL, Dupuis NF, Lazo ND, Wyttenbach T, Condron MM, Bitan G, Teplow DB, Shea JE, Ruotolo BT, Robinson CV, Bowers MT. PMID: 20703363; PMCID: PMC2918915.
      View in: PubMed   Mentions: 355     Fields:    Translation:Humans
    91. Amino acid position-specific contributions to amyloid beta-protein oligomerization. J Biol Chem. 2009 Aug 28; 284(35):23580-91. Maji SK, Ogorzalek Loo RR, Inayathullah M, Spring SM, Vollers SS, Condron MM, Bitan G, Loo JA, Teplow DB. PMID: 19567875; PMCID: PMC2749133.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    92. The structure of Abeta42 C-terminal fragments probed by a combined experimental and theoretical study. J Mol Biol. 2009 Mar 27; 387(2):492-501. Wu C, Murray MM, Bernstein SL, Condron MM, Bitan G, Shea JE, Bowers MT. PMID: 19356595; PMCID: PMC2712569.
      View in: PubMed   Mentions: 28     Fields:    Translation:Cells
    93. Photo-induced cross-linking of unmodified proteins (PICUP) applied to amyloidogenic peptides. J Vis Exp. 2009 Jan 12; (23). Rahimi F, Maiti P, Bitan G. PMID: 19229175; PMCID: PMC2763294.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    94. C-terminal peptides coassemble into Abeta42 oligomers and protect neurons against Abeta42-induced neurotoxicity. Proc Natl Acad Sci U S A. 2008 Sep 16; 105(37):14175-80. Fradinger EA, Monien BH, Urbanc B, Lomakin A, Tan M, Li H, Spring SM, Condron MM, Cruz L, Xie CW, Benedek GB, Bitan G. PMID: 18779585; PMCID: PMC2544597.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    95. Structure-function relationships of pre-fibrillar protein assemblies in Alzheimer's disease and related disorders. Curr Alzheimer Res. 2008 Jun; 5(3):319-41. Rahimi F, Shanmugam A, Bitan G. PMID: 18537546; PMCID: PMC2835858.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    96. Synthesis and Purification of Highly Hydrophobic Peptides Derived from the C-Terminus of Amyloid β-Protein. Open Biotechnol J. 2008 Jan 01; 2(1):87-93. Condron MM, Monien BH, Bitan G. PMID: 19898686; PMCID: PMC2773559.
      View in: PubMed   Mentions: 14  
    97. Role of electrostatic interactions in amyloid beta-protein (A beta) oligomer formation: a discrete molecular dynamics study. Biophys J. 2007 Jun 01; 92(11):4064-77. Yun S, Urbanc B, Cruz L, Bitan G, Teplow DB, Stanley HE. PMID: 17307823; PMCID: PMC1868995.
      View in: PubMed   Mentions: 48     Fields:    Translation:Cells
    98. Early diagnostics and therapeutics for Alzheimer's disease--how early can we get there? Expert Rev Neurother. 2006 Sep; 6(9):1293-306. Monien BH, Apostolova LG, Bitan G. PMID: 17009917; PMCID: PMC2715564.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    99. Elucidating amyloid beta-protein folding and assembly: A multidisciplinary approach. Acc Chem Res. 2006 Sep; 39(9):635-45. Teplow DB, Lazo ND, Bitan G, Bernstein S, Wyttenbach T, Bowers MT, Baumketner A, Shea JE, Urbanc B, Cruz L, Borreguero J, Stanley HE. PMID: 16981680.
      View in: PubMed   Mentions: 83     Fields:    Translation:Cells
    100. Dendrimeric Abeta1-15 is an effective immunogen in wildtype and APP-tg mice. Neurobiol Aging. 2007 Jun; 28(6):813-23. Seabrook TJ, Thomas K, Jiang L, Bloom J, Spooner E, Maier M, Bitan G, Lemere CA. PMID: 16725229.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    101. Amyloid beta-protein monomer structure: a computational and experimental study. Protein Sci. 2006 Mar; 15(3):420-8. Baumketner A, Bernstein SL, Wyttenbach T, Bitan G, Teplow DB, Bowers MT, Shea JE. PMID: 16501222; PMCID: PMC2249763.
      View in: PubMed   Mentions: 86     Fields:    Translation:Cells
    102. Structural study of metastable amyloidogenic protein oligomers by photo-induced cross-linking of unmodified proteins. Methods Enzymol. 2006; 413:217-36. Bitan G. PMID: 17046399; PMCID: PMC2782599.
      View in: PubMed   Mentions: 44     Fields:    Translation:Cells
    103. En route to early diagnosis of Alzheimer's disease--are we there yet? Trends Biotechnol. 2005 Nov; 23(11):531-3. Fradinger EA, Bitan G. PMID: 16165236.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    104. Neurotoxic protein oligomers--what you see is not always what you get. Amyloid. 2005 Jun; 12(2):88-95. Bitan G, Fradinger EA, Spring SM, Teplow DB. PMID: 16011984.
      View in: PubMed   Mentions: 99     Fields:    
    105. Amyloid beta-protein: monomer structure and early aggregation states of Abeta42 and its Pro19 alloform. J Am Chem Soc. 2005 Feb 23; 127(7):2075-84. Bernstein SL, Wyttenbach T, Baumketner A, Shea JE, Bitan G, Teplow DB, Bowers MT. PMID: 15713083.
      View in: PubMed   Mentions: 123     Fields:    Translation:Cells
    106. Preparation of aggregate-free, low molecular weight amyloid-beta for assembly and toxicity assays. Methods Mol Biol. 2005; 299:3-9. Bitan G, Teplow DB. PMID: 15980591.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    107. Determination of Peptide oligomerization state using rapid photochemical crosslinking. Methods Mol Biol. 2005; 299:11-8. Vollers SS, Teplow DB, Bitan G. PMID: 15980592.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    108. In silico study of amyloid beta-protein folding and oligomerization. Proc Natl Acad Sci U S A. 2004 Dec 14; 101(50):17345-50. Urbanc B, Cruz L, Yun S, Buldyrev SV, Bitan G, Teplow DB, Stanley HE. PMID: 15583128; PMCID: PMC536046.
      View in: PubMed   Mentions: 113     Fields:    Translation:Cells
    109. Rapid photochemical cross-linking--a new tool for studies of metastable, amyloidogenic protein assemblies. Acc Chem Res. 2004 Jun; 37(6):357-64. Bitan G, Teplow DB. PMID: 15196045.
      View in: PubMed   Mentions: 84     Fields:    Translation:Cells
    110. A molecular switch in amyloid assembly: Met35 and amyloid beta-protein oligomerization. J Am Chem Soc. 2003 Dec 17; 125(50):15359-65. Bitan G, Tarus B, Vollers SS, Lashuel HA, Condron MM, Straub JE, Teplow DB. PMID: 14664580.
      View in: PubMed   Mentions: 57     Fields:    Translation:Cells
    111. Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease. J Clin Invest. 2003 Aug; 112(3):415-22. Monsonego A, Zota V, Karni A, Krieger JI, Bar-Or A, Bitan G, Budson AE, Sperling R, Selkoe DJ, Weiner HL. PMID: 12897209; PMCID: PMC166296.
      View in: PubMed   Mentions: 131     Fields:    Translation:HumansAnimalsCells
    112. Elucidation of primary structure elements controlling early amyloid beta-protein oligomerization. J Biol Chem. 2003 Sep 12; 278(37):34882-9. Bitan G, Vollers SS, Teplow DB. PMID: 12840029.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansCells
    113. Amyloid beta -protein (Abeta) assembly: Abeta 40 and Abeta 42 oligomerize through distinct pathways. Proc Natl Acad Sci U S A. 2003 Jan 07; 100(1):330-5. Bitan G, Kirkitadze MD, Lomakin A, Vollers SS, Benedek GB, Teplow DB. PMID: 12506200; PMCID: PMC140968.
      View in: PubMed   Mentions: 447     Fields:    Translation:Humans
    114. Paradigm shifts in Alzheimer's disease and other neurodegenerative disorders: the emerging role of oligomeric assemblies. J Neurosci Res. 2002 Sep 01; 69(5):567-77. Kirkitadze MD, Bitan G, Teplow DB. PMID: 12210822.
      View in: PubMed   Mentions: 222     Fields:    Translation:HumansAnimalsCells
    115. Identification of a contact domain between echistatin and the integrin alpha(v)beta(3) by photoaffinity cross-linking. Biochemistry. 2001 Dec 18; 40(50):15117-26. Scheibler L, Mierke DF, Bitan G, Rosenblatt M, Chorev M. PMID: 11735394.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    116. Amyloid beta-protein oligomerization: prenucleation interactions revealed by photo-induced cross-linking of unmodified proteins. J Biol Chem. 2001 Sep 14; 276(37):35176-84. Bitan G, Lomakin A, Teplow DB. PMID: 11441003.
      View in: PubMed   Mentions: 139     Fields:    
    117. The relationship between homology length and crossing over during the repair of a broken chromosome. J Biol Chem. 2000 Oct 06; 275(40):30833-8. Inbar O, Liefshitz B, Bitan G, Kupiec M. PMID: 10924495.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    118. Ligand-integrin alpha v beta 3 interaction determined by photoaffinity cross-linking: a challenge to the prevailing model. Biochemistry. 2000 Sep 12; 39(36):11014-23. Bitan G, Scheibler L, Mierke DF, Rosenblatt M, Chorev M. PMID: 10998238.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    119. Design and evaluation of benzophenone-containing conformationally constrained ligands as tools for photoaffinity scanning of the integrin alphaVbeta3-ligand bimolecular interaction. J Pept Res. 2000 Mar; 55(3):181-94. Bitan G, Scheibler L, Teng H, Rosenblatt M, Chorev M. PMID: 10727100.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    120. Photoaffinity cross-linking identifies differences in the interactions of an agonist and an antagonist with the parathyroid hormone/parathyroid hormone-related protein receptor. J Biol Chem. 2000 Jan 07; 275(1):9-17. Behar V, Bisello A, Bitan G, Rosenblatt M, Chorev M. PMID: 10617579.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    121. Mapping the integrin alpha V beta 3-ligand interface by photoaffinity cross-linking. Biochemistry. 1999 Mar 16; 38(11):3414-20. Bitan G, Scheibler L, Greenberg Z, Rosenblatt M, Chorev M. PMID: 10079087.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    122. Synthesis and biological activity of novel backbone-bicyclic substance-P analogs containing lactam and disulfide bridges. J Pept Res. 1997 May; 49(5):421-6. Bitan G, Sukhotinsky I, Mashriki Y, Hanani M, Selinger Z, Gilon C. PMID: 9211223.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    123. Structure-activity relationship of the ring portion in backbone-cyclic C-terminal hexapeptide analogs of substance P. NMR and molecular dynamics. Int J Pept Protein Res. 1996 Dec; 48(6):569-79. Behrens S, Mathä B, Bitan G, Gilon C, Kessler H. PMID: 8985790.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    124. Synthesis and biological activity of NK-1 selective, N-backbone cyclic analogs of the C-terminal hexapeptide of substance P. J Med Chem. 1996 Aug 02; 39(16):3174-8. Byk G, Halle D, Zeltser I, Bitan G, Selinger Z, Gilon C. PMID: 8759639.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    125. Backbone cyclization of the C-terminal part of substance P. Part 1: The important role of the sulphur in position 11. J Pept Sci. 1996 Jul-Aug; 2(4):261-9. Bitan G, Zeltser I, Byk G, Halle D, Mashriki Y, Gluhov EV, Sukhotinsky I, Hanani M, Selinger Z, Gilon C. PMID: 9231334.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
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