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Gal Bitan

Title(s)Professor-in-Residence, Neurology
SchoolMedicine
Address760 Westwood Plaza 477
Los Angeles CA 90024
Phone62082
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    Collapse Research 
    Collapse Research Activities and Funding
    Investigation of the effect of structural modifications of tau on assembly state and seeding
    NIH/NIA R01AG054000Jul 15, 2017 - May 31, 2022
    Role: Principal Investigator
    Misfolded protein clearance enhancers for Alzheimers therapy
    NIH/NIA R01AG050721Sep 15, 2015 - Apr 30, 2020
    Role: Principal Investigator
    Novel Specific Ligands for ABeta Oligomers
    NIH/NIA R21AG030709Sep 1, 2007 - May 31, 2010
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Examination of SOD1 aggregation modulators and their effect on SOD1 enzymatic activity as a proxy for potential toxicity. FASEB J. 2020 Jul 23. Malik R, Corrales C, Linsenmeier M, Alalami H, Sepanj N, Bitan G. PMID: 32701214.
      View in: PubMed   Mentions:    Fields:    
    2. Different Inhibitors of Aß42-Induced Toxicity Have Distinct Metal-Ion Dependency. ACS Chem Neurosci. 2020 Aug 05; 11(15):2243-2255. Mason AJ, Hurst I, Malik R, Siddique I, Solomonov I, Sagi I, Klärner FG, Schrader T, Bitan G. PMID: 32559370.
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    3. The recent failure of the PROMESA clinical trial for multiple system atrophy raises the question-are polyphenols a viable therapeutic option against proteinopathies? Ann Transl Med. 2020 Jun; 8(11):719. Bitan G. PMID: 32617339.
      View in: PubMed   Mentions:
    4. CNS-Derived Blood Exosomes as a Promising Source of Biomarkers: Opportunities and Challenges. Front Mol Neurosci. 2020; 13:38. Hornung S, Dutta S, Bitan G. PMID: 32265650.
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    5. The Amyloid Inhibitor CLR01 Relieves Autophagy and Ameliorates Neuropathology in a Severe Lysosomal Storage Disease. Mol Ther. 2020 04 08; 28(4):1167-1176. Monaco A, Maffia V, Sorrentino NC, Sambri I, Ezhova Y, Giuliano T, Cacace V, Nusco E, De Risi M, De Leonibus E, Schrader T, Klärner FG, Bitan G, Fraldi A. PMID: 32087148.
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    6. Different Amyloid-ß Self-Assemblies Have Distinct Effects on Intracellular Tau Aggregation. Front Mol Neurosci. 2019; 12:268. Shin WS, Di J, Murray KA, Sun C, Li B, Bitan G, Jiang L. PMID: 31787880.
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    7. Amyloid ß-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation. Alzheimers Res Ther. 2019 10 18; 11(1):86. Shin WS, Di J, Cao Q, Li B, Seidler PM, Murray KA, Bitan G, Jiang L. PMID: 31627745.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    8. Molecular Lysine Tweezers Counteract Aberrant Protein Aggregation. Front Chem. 2019; 7:657. Hadrovic I, Rebmann P, Klärner FG, Bitan G, Schrader T. PMID: 31632951.
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    9. Disease-modifying therapy for proteinopathies: Can the exception become the rule? Prog Mol Biol Transl Sci. 2019; 168:277-287. Bitan G. PMID: 31699321.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    10. The molecular tweezer CLR01 reduces aggregated, pathologic, and seeding-competent a-synuclein in experimental multiple system atrophy. Biochim Biophys Acta Mol Basis Dis. 2019 11 01; 1865(11):165513. Herrera-Vaquero M, Bouquio D, Kallab M, Biggs K, Nair G, Ochoa J, Heras-Garvin A, Heid C, Hadrovic I, Poewe W, Wenning GK, Klärner FG, Schrader T, Bitan G, Stefanova N. PMID: 31319154.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    11. Major Differences between the Self-Assembly and Seeding Behavior of Heparin-Induced and in Vitro Phosphorylated Tau and Their Modulation by Potential Inhibitors. ACS Chem Biol. 2019 06 21; 14(6):1363-1379. Despres C, Di J, Cantrelle FX, Li Z, Huvent I, Chambraud B, Zhao J, Chen J, Chen S, Lippens G, Zhang F, Linhardt R, Wang C, Klärner FG, Schrader T, Landrieu I, Bitan G, Smet-Nocca C. PMID: 31046227.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    12. The molecular tweezer CLR01 inhibits aberrant superoxide dismutase 1 (SOD1) self-assembly in vitro and in the G93A-SOD1 mouse model of ALS. J Biol Chem. 2019 03 08; 294(10):3501-3513. Malik R, Meng H, Wongkongkathep P, Corrales CI, Sepanj N, Atlasi RS, Klärner FG, Schrader T, Spencer MJ, Loo JA, Wiedau M, Bitan G. PMID: 30602569.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    13. Native Top-Down Mass Spectrometry and Ion Mobility Spectrometry of the Interaction of Tau Protein with a Molecular Tweezer Assembly Modulator. J Am Soc Mass Spectrom. 2019 Jan; 30(1):16-23. Nshanian M, Lantz C, Wongkongkathep P, Schrader T, Klärner FG, Blümke A, Despres C, Ehrmann M, Smet-Nocca C, Bitan G, Loo JA. PMID: 30062477.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    14. The molecular tweezer CLR01 inhibits Ebola and Zika virus infection. Antiviral Res. 2018 04; 152:26-35. Röcker AE, Müller JA, Dietzel E, Harms M, Krüger F, Heid C, Sowislok A, Riber CF, Kupke A, Lippold S, von Einem J, Beer J, Knöll B, Becker S, Schmidt-Chanasit J, Otto M, Vapalahti O, Zelikin AN, Bitan G, Schrader T, Münch J. PMID: 29428508.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    15. Using Molecular Tweezers to Remodel Abnormal Protein Self-Assembly and Inhibit the Toxicity of Amyloidogenic Proteins. Methods Mol Biol. 2018; 1777:369-386. Malik R, Di J, Nair G, Attar A, Taylor K, Teng E, Klärner FG, Schrader T, Bitan G. PMID: 29744849.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    16. Preparation of Pure Populations of Amyloid ß-Protein Oligomers of Defined Size. Methods Mol Biol. 2018; 1779:3-12. Hayden EY, Conovaloff JL, Mason A, Bitan G, Teplow DB. PMID: 29886523.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    17. Recommendations of the Global Multiple System Atrophy Research Roadmap Meeting. Neurology. 2018 01 09; 90(2):74-82. Walsh RR, Krismer F, Galpern WR, Wenning GK, Low PA, Halliday G, Koroshetz WJ, Holton J, Quinn NP, Rascol O, Shaw LM, Eidelberg D, Bower P, Cummings JL, Abler V, Biedenharn J, Bitan G, Brooks DJ, Brundin P, Fernandez H, Fortier P, Freeman R, Gasser T, Hewitt A, Höglinger GU, Huentelman MJ, Jensen PH, Jeromin A, Kang UJ, Kaufmann H, Kellerman L, Khurana V, Klockgether T, Kim WS, Langer C, LeWitt P, Masliah E, Meissner W, Melki R, Ostrowitzki S, Piantadosi S, Poewe W, Robertson D, Roemer C, Schenk D, Schlossmacher M, Schmahmann JD, Seppi K, Shih L, Siderowf A, Stebbins GT, Stefanova N, Tsuji S, Sutton S, Zhang J. PMID: 29237794.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    18. A Molecular Tweezer Ameliorates Motor Deficits in Mice Overexpressing a-Synuclein. Neurotherapeutics. 2017 Oct; 14(4):1107-1119. Richter F, Subramaniam SR, Magen I, Lee P, Hayes J, Attar A, Zhu C, Franich NR, Bove N, De La Rosa K, Kwong J, Klärner FG, Schrader T, Chesselet MF, Bitan G. PMID: 28585223.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    19. Inhibition of Mutant aB Crystallin-Induced Protein Aggregation by a Molecular Tweezer. J Am Heart Assoc. 2017 Aug 08; 6(8). Xu N, Bitan G, Schrader T, Klärner FG, Osinska H, Robbins J. PMID: 28862927.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    20. Inhibition of Huntingtin Exon-1 Aggregation by the Molecular Tweezer CLR01. J Am Chem Soc. 2017 04 26; 139(16):5640-5643. Vöpel T, Bravo-Rodriguez K, Mittal S, Vachharajani S, Gnutt D, Sharma A, Steinhof A, Fatoba O, Ellrichmann G, Nshanian M, Heid C, Loo JA, Klärner FG, Schrader T, Bitan G, Wanker EE, Ebbinghaus S, Sanchez-Garcia E. PMID: 28406616.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    21. Computational On-Chip Imaging of Nanoparticles and Biomolecules using Ultraviolet Light. Sci Rep. 2017 03 09; 7:44157. Daloglu MU, Ray A, Gorocs Z, Xiong M, Malik R, Bitan G, McLeod E, Ozcan A. PMID: 28276489.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    22. Preparation of pure populations of covalently stabilized amyloid ß-protein oligomers of specific sizes. Anal Biochem. 2017 Feb 01; 518:78-85. Hayden EY, Conovaloff JL, Mason A, Bitan G, Teplow DB. PMID: 27810329.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    23. Molecular tweezers for lysine and arginine - powerful inhibitors of pathologic protein aggregation. Chem Commun (Camb). 2016 Oct 15; 52(76):11318-34. Schrader T, Bitan G, Klärner FG. PMID: 27546596.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    24. Neurotoxicity of the Parkinson Disease-Associated Pesticide Ziram Is Synuclein-Dependent in Zebrafish Embryos. Environ Health Perspect. 2016 Nov; 124(11):1766-1775. Lulla A, Barnhill L, Bitan G, Ivanova MI, Nguyen B, O'Donnell K, Stahl MC, Yamashiro C, Klärner FG, Schrader T, Sagasti A, Bronstein JM. PMID: 27301718.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    25. Reducing synuclein accumulation improves neuronal survival after spinal cord injury. Exp Neurol. 2016 Apr; 278:105-15. Fogerson SM, van Brummen AJ, Busch DJ, Allen SR, Roychaudhuri R, Banks SM, Klärner FG, Schrader T, Bitan G, Morgan JR. PMID: 26854933.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    26. Role of Species-Specific Primary Structure Differences in Aß42 Assembly and Neurotoxicity. ACS Chem Neurosci. 2015 Dec 16; 6(12):1941-55. Roychaudhuri R, Zheng X, Lomakin A, Maiti P, Condron MM, Benedek GB, Bitan G, Bowers MT, Teplow DB. PMID: 26421877.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    27. Toxicity inhibitors protect lipid membranes from disruption by Aß42. ACS Chem Neurosci. 2015 Nov 18; 6(11):1860-9. Malishev R, Nandi S, Kolusheva S, Levi-Kalisman Y, Klärner FG, Schrader T, Bitan G, Jelinek R. PMID: 26317327.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    28. A molecular tweezer antagonizes seminal amyloids and HIV infection. Elife. 2015 Aug 18; 4. Lump E, Castellano LM, Meier C, Seeliger J, Erwin N, Sperlich B, Stürzel CM, Usmani S, Hammond RM, von Einem J, Gerold G, Kreppel F, Bravo-Rodriguez K, Pietschmann T, Holmes VM, Palesch D, Zirafi O, Weissman D, Sowislok A, Wettig B, Heid C, Kirchhoff F, Weil T, Klärner FG, Schrader T, Bitan G, Sanchez-Garcia E, Winter R, Shorter J, Münch J. PMID: 26284498.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    29. The Lys-Specific Molecular Tweezer, CLR01, Modulates Aggregation of the Mutant p53 DNA Binding Domain and Inhibits Its Toxicity. Biochemistry. 2015 Jun 23; 54(24):3729-38. Herzog G, Shmueli MD, Levy L, Engel L, Gazit E, Klärner FG, Schrader T, Bitan G, Segal D. PMID: 26030124.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    30. Molecular tweezers inhibit islet amyloid polypeptide assembly and toxicity by a new mechanism. ACS Chem Biol. 2015 Jun 19; 10(6):1555-69. Lopes DH, Attar A, Nair G, Hayden EY, Du Z, McDaniel K, Dutt S, Bravo-Rodriguez K, Mittal S, Klärner FG, Wang C, Sanchez-Garcia E, Schrader T, Bitan G. PMID: 25844890.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    31. Amyloid ß-protein assembly: The effect of molecular tweezers CLR01 and CLR03. J Phys Chem B. 2015 Apr 09; 119(14):4831-41. Zheng X, Liu D, Klärner FG, Schrader T, Bitan G, Bowers MT. PMID: 25751170.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    32. Safety and pharmacological characterization of the molecular tweezer CLR01 - a broad-spectrum inhibitor of amyloid proteins' toxicity. BMC Pharmacol Toxicol. 2014 Apr 16; 15:23. Attar A, Chan WT, Klärner FG, Schrader T, Bitan G. PMID: 24735982.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    33. Molecular tweezers targeting transthyretin amyloidosis. Neurotherapeutics. 2014 Apr; 11(2):450-61. Ferreira N, Pereira-Henriques A, Attar A, Klärner FG, Schrader T, Bitan G, Gales L, Saraiva MJ, Almeida MR. PMID: 24459092.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    34. Molecular basis for preventing a-synuclein aggregation by a molecular tweezer. J Biol Chem. 2014 Apr 11; 289(15):10727-37. Acharya S, Safaie BM, Wongkongkathep P, Ivanova MI, Attar A, Klärner FG, Schrader T, Loo JA, Bitan G, Lapidus LJ. PMID: 24567327.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    35. Disrupting self-assembly and toxicity of amyloidogenic protein oligomers by "molecular tweezers" - from the test tube to animal models. Curr Pharm Des. 2014; 20(15):2469-83. Attar A, Bitan G. PMID: 23859557.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    36. A shortened Barnes maze protocol reveals memory deficits at 4-months of age in the triple-transgenic mouse model of Alzheimer's disease. PLoS One. 2013; 8(11):e80355. Attar A, Liu T, Chan WT, Hayes J, Nejad M, Lei K, Bitan G. PMID: 24236177.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    37. Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers. Brain. 2012 Dec; 135(Pt 12):3735-48. Attar A, Ripoli C, Riccardi E, Maiti P, Li Puma DD, Liu T, Hayes J, Jones MR, Lichti-Kaiser K, Yang F, Gale GD, Tseng CH, Tan M, Xie CW, Straudinger JL, Klärner FG, Schrader T, Frautschy SA, Grassi C, Bitan G. PMID: 23183235.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    38. Effects of different amyloid ß-protein analogues on synaptic function. Neurobiol Aging. 2013 Apr; 34(4):1032-44. Ripoli C, Piacentini R, Riccardi E, Leone L, Li Puma DD, Bitan G, Grassi C. PMID: 23046860.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    39. Plasma methionine sulfoxide in persons with familial Alzheimer's disease mutations. Dement Geriatr Cogn Disord. 2012; 33(4):219-25. Ringman JM, Fithian AT, Gylys K, Cummings JL, Coppola G, Elashoff D, Pratico D, Moskovitz J, Bitan G. PMID: 22584618.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    40. Zn2+-Aß40 complexes form metastable quasi-spherical oligomers that are cytotoxic to cultured hippocampal neurons. J Biol Chem. 2012 Jun 08; 287(24):20555-64. Solomonov I, Korkotian E, Born B, Feldman Y, Bitler A, Rahimi F, Li H, Bitan G, Sagi I. PMID: 22528492.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    41. A novel "molecular tweezer" inhibitor of a-synuclein neurotoxicity in vitro and in vivo. Neurotherapeutics. 2012 Apr; 9(2):464-76. Prabhudesai S, Sinha S, Attar A, Kotagiri A, Fitzmaurice AG, Lakshmanan R, Lakshmanan R, Ivanova MI, Loo JA, Klärner FG, Schrader T, Stahl M, Bitan G, Bronstein JM. PMID: 22373667.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    42. A key role for lysine residues in amyloid ß-protein folding, assembly, and toxicity. ACS Chem Neurosci. 2012 Jun 20; 3(6):473-81. Sinha S, Lopes DH, Bitan G. PMID: 22860216.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    43. Comparison of three amyloid assembly inhibitors: the sugar scyllo-inositol, the polyphenol epigallocatechin gallate, and the molecular tweezer CLR01. ACS Chem Neurosci. 2012 Jun 20; 3(6):451-8. Sinha S, Du Z, Maiti P, Klärner FG, Schrader T, Wang C, Bitan G. PMID: 22860214.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    44. Modulating self-assembly of amyloidogenic proteins as a therapeutic approach for neurodegenerative diseases: strategies and mechanisms. ChemMedChem. 2012 Mar 05; 7(3):359-74. Liu T, Bitan G. PMID: 22323134.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    45. Application of photochemical cross-linking to the study of oligomerization of amyloidogenic proteins. Methods Mol Biol. 2012; 849:11-21. Lopes DH, Sinha S, Rosensweig C, Bitan G. PMID: 22528080.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    46. Preparation of stable amyloid ß-protein oligomers of defined assembly order. Methods Mol Biol. 2012; 849:23-31. Rosensweig C, Ono K, Murakami K, Lowenstein DK, Bitan G, Teplow DB. PMID: 22528081.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    47. Aß(39-42) modulates Aß oligomerization but not fibril formation. Biochemistry. 2012 Jan 10; 51(1):108-17. Gessel MM, Wu C, Li H, Bitan G, Shea JE, Bowers MT. PMID: 22129303.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    48. C-terminal tetrapeptides inhibit Aß42-induced neurotoxicity primarily through specific interaction at the N-terminus of Aß42. J Med Chem. 2011 Dec 22; 54(24):8451-60. Li H, Du Z, Lopes DH, Fradinger EA, Wang C, Bitan G. PMID: 22087474.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    49. Induction of methionine-sulfoxide reductases protects neurons from amyloid ß-protein insults in vitro and in vivo. Biochemistry. 2011 Dec 13; 50(49):10687-97. Moskovitz J, Maiti P, Lopes DH, Oien DB, Attar A, Liu T, Mittal S, Hayes J, Bitan G. PMID: 22059533.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    50. Lysine-specific molecular tweezers are broad-spectrum inhibitors of assembly and toxicity of amyloid proteins. J Am Chem Soc. 2011 Oct 26; 133(42):16958-69. Sinha S, Lopes DH, Du Z, Pang ES, Shanmugam A, Lomakin A, Talbiersky P, Tennstaedt A, McDaniel K, Bakshi R, Kuo PY, Ehrmann M, Benedek GB, Loo JA, Klärner FG, Schrader T, Wang C, Bitan G. PMID: 21916458.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    51. Rational design of ß-sheet ligands against Aß42-induced toxicity. J Am Chem Soc. 2011 Mar 30; 133(12):4348-58. Hochdörffer K, März-Berberich J, Nagel-Steger L, Epple M, Meyer-Zaika W, Horn AH, Sticht H, Sinha S, Bitan G, Schrader T. PMID: 21381732.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    52. Surprising toxicity and assembly behaviour of amyloid ß-protein oxidized to sulfone. Biochem J. 2011 Jan 15; 433(2):323-32. Maiti P, Piacentini R, Ripoli C, Grassi C, Bitan G. PMID: 21044048.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    53. Mechanistic investigation of the inhibition of Abeta42 assembly and neurotoxicity by Abeta42 C-terminal fragments. Biochemistry. 2010 Aug 03; 49(30):6358-64. Li H, Monien BH, Lomakin A, Zemel R, Fradinger EA, Tan M, Spring SM, Urbanc B, Xie CW, Benedek GB, Bitan G. PMID: 20568734.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    54. Selection of aptamers for amyloid beta-protein, the causative agent of Alzheimer's disease. J Vis Exp. 2010 May 13; (39). Rahimi F, Bitan G. PMID: 20616783.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    55. Despite its role in assembly, methionine 35 is not necessary for amyloid beta-protein toxicity. J Neurochem. 2010 Jun; 113(5):1252-62. Maiti P, Lomakin A, Benedek GB, Bitan G. PMID: 20345758.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    56. Biophysical characterization of Abeta42 C-terminal fragments: inhibitors of Abeta42 neurotoxicity. Biochemistry. 2010 Feb 16; 49(6):1259-67. Li H, Monien BH, Fradinger EA, Urbanc B, Bitan G. PMID: 20050679.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    57. RNA aptamers generated against oligomeric Abeta40 recognize common amyloid aptatopes with low specificity but high sensitivity. PLoS One. 2009 Nov 10; 4(11):e7694. Rahimi F, Murakami K, Summers JL, Chen CH, Bitan G. PMID: 19901993.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    58. Amyloid-ß protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease. Nat Chem. 2009 Jul; 1(4):326-31. Bernstein SL, Dupuis NF, Lazo ND, Wyttenbach T, Condron MM, Bitan G, Teplow DB, Shea JE, Ruotolo BT, Robinson CV, Bowers MT. PMID: 20703363.
      View in: PubMed   Mentions: 246     Fields:    Translation:Humans
    59. Amino acid position-specific contributions to amyloid beta-protein oligomerization. J Biol Chem. 2009 Aug 28; 284(35):23580-91. Maji SK, Ogorzalek Loo RR, Inayathullah M, Spring SM, Vollers SS, Condron MM, Bitan G, Loo JA, Teplow DB. PMID: 19567875.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    60. Photo-induced cross-linking of unmodified proteins (PICUP) applied to amyloidogenic peptides. J Vis Exp. 2009 Jan 12; (23). Rahimi F, Maiti P, Bitan G. PMID: 19229175.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    61. C-terminal peptides coassemble into Abeta42 oligomers and protect neurons against Abeta42-induced neurotoxicity. Proc Natl Acad Sci U S A. 2008 Sep 16; 105(37):14175-80. Fradinger EA, Monien BH, Urbanc B, Lomakin A, Tan M, Li H, Spring SM, Condron MM, Cruz L, Xie CW, Benedek GB, Bitan G. PMID: 18779585.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    62. Elucidating amyloid beta-protein folding and assembly: A multidisciplinary approach. Acc Chem Res. 2006 Sep; 39(9):635-45. Teplow DB, Lazo ND, Bitan G, Bernstein S, Wyttenbach T, Bowers MT, Baumketner A, Shea JE, Urbanc B, Cruz L, Borreguero J, Stanley HE. PMID: 16981680.
      View in: PubMed   Mentions: 69     Fields:    Translation:Cells
    63. Dendrimeric Abeta1-15 is an effective immunogen in wildtype and APP-tg mice. Neurobiol Aging. 2007 Jun; 28(6):813-23. Seabrook TJ, Thomas K, Jiang L, Bloom J, Spooner E, Maier M, Bitan G, Lemere CA. PMID: 16725229.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    64. Amyloid beta-protein monomer structure: a computational and experimental study. Protein Sci. 2006 Mar; 15(3):420-8. Baumketner A, Bernstein SL, Wyttenbach T, Bitan G, Teplow DB, Bowers MT, Shea JE. PMID: 16501222.
      View in: PubMed   Mentions: 75     Fields:    Translation:Cells
    65. Structural study of metastable amyloidogenic protein oligomers by photo-induced cross-linking of unmodified proteins. Methods Enzymol. 2006; 413:217-36. Bitan G. PMID: 17046399.
      View in: PubMed   Mentions: 31     Fields:    Translation:Cells
    66. En route to early diagnosis of Alzheimer's disease--are we there yet? Trends Biotechnol. 2005 Nov; 23(11):531-3. Fradinger EA, Bitan G. PMID: 16165236.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    67. Neurotoxic protein oligomers--what you see is not always what you get. Amyloid. 2005 Jun; 12(2):88-95. Bitan G, Fradinger EA, Spring SM, Teplow DB. PMID: 16011984.
      View in: PubMed   Mentions: 78     Fields:    
    68. Amyloid beta-protein: monomer structure and early aggregation states of Abeta42 and its Pro19 alloform. J Am Chem Soc. 2005 Feb 23; 127(7):2075-84. Bernstein SL, Wyttenbach T, Baumketner A, Shea JE, Bitan G, Teplow DB, Bowers MT. PMID: 15713083.
      View in: PubMed   Mentions: 104     Fields:    Translation:Cells
    69. Preparation of aggregate-free, low molecular weight amyloid-beta for assembly and toxicity assays. Methods Mol Biol. 2005; 299:3-9. Bitan G, Teplow DB. PMID: 15980591.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    70. Determination of Peptide oligomerization state using rapid photochemical crosslinking. Methods Mol Biol. 2005; 299:11-8. Vollers SS, Teplow DB, Bitan G. PMID: 15980592.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    71. Rapid photochemical cross-linking--a new tool for studies of metastable, amyloidogenic protein assemblies. Acc Chem Res. 2004 Jun; 37(6):357-64. Bitan G, Teplow DB. PMID: 15196045.
      View in: PubMed   Mentions: 58     Fields:    Translation:Cells
    72. A molecular switch in amyloid assembly: Met35 and amyloid beta-protein oligomerization. J Am Chem Soc. 2003 Dec 17; 125(50):15359-65. Bitan G, Tarus B, Vollers SS, Lashuel HA, Condron MM, Straub JE, Teplow DB. PMID: 14664580.
      View in: PubMed   Mentions: 45     Fields:    Translation:Cells
    73. Elucidation of primary structure elements controlling early amyloid beta-protein oligomerization. J Biol Chem. 2003 Sep 12; 278(37):34882-9. Bitan G, Vollers SS, Teplow DB. PMID: 12840029.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansCells
    74. Amyloid beta -protein (Abeta) assembly: Abeta 40 and Abeta 42 oligomerize through distinct pathways. Proc Natl Acad Sci U S A. 2003 Jan 07; 100(1):330-5. Bitan G, Kirkitadze MD, Lomakin A, Vollers SS, Benedek GB, Teplow DB. PMID: 12506200.
      View in: PubMed   Mentions: 329     Fields:    Translation:Humans
    75. Polyglutamine repeat length-dependent proteolysis of huntingtin. Neurobiol Dis. 2002 Oct; 11(1):111-22. Sun B, Fan W, Balciunas A, Cooper JK, Bitan G, Steavenson S, Denis PE, Young Y, Adler B, Daugherty L, Manoukian R, Elliott G, Shen W, Talvenheimo J, Teplow DB, Haniu M, Haldankar R, Wypych J, Ross CA, Citron M, Richards WG. PMID: 12460551.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    76. Paradigm shifts in Alzheimer's disease and other neurodegenerative disorders: the emerging role of oligomeric assemblies. J Neurosci Res. 2002 Sep 01; 69(5):567-77. Kirkitadze MD, Bitan G, Teplow DB. PMID: 12210822.
      View in: PubMed   Mentions: 183     Fields:    Translation:HumansAnimalsCells
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