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Anti-amyloid treatment is broadly effective in neuronopathic mucopolysaccharidoses and synergizes with gene therapy in MPS-IIIA. Mol Ther. 2024 Sep 28.
Giaccio M, Monaco A, Galiano L, Parente A, Borzacchiello L, Rubino R, Klärner FG, Killa D, Perna C, Piccolo P, Marotta M, Pan X, Khijniak M, Siddique I, Schrader T, Pshezhetsky AV, Sorrentino NC, Bitan G, Fraldi A. PMID: 39342429.
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PubMed Mentions: Fields:
-
Author Correction: Anakinra in Sanfilippo syndrome: a phase 1/2 trial. Nat Med. 2024 Sep; 30(9):2693.
Polgreen LE, Chen AH, Pak Y, Luzzi A, Morales Garval A, Acevedo J, Bitan G, Iacovino M, O'Neill C, Eisengart JB. PMID: 39075282; PMCID: PMC11405256.
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PubMed Mentions: Fields:
-
Anakinra in Sanfilippo syndrome: a phase 1/2 trial. Nat Med. 2024 Sep; 30(9):2473-2479.
Polgreen LE, Chen AH, Pak Y, Luzzi A, Morales Garval A, Acevedo J, Bitan G, Iacovino M, O'Neill C, Eisengart JB. PMID: 38907160; PMCID: PMC11405265.
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PubMed Mentions: Fields:
Translation:
HumansCTClinical Trials
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Novel avenues of tau research. Alzheimers Dement. 2024 03; 20(3):2240-2261.
Sexton CE, Bitan G, Bowles KR, Brys M, Buée L, Maina MB, Clelland CD, Cohen AD, Crary JF, Dage JL, Diaz K, Frost B, Gan L, Goate AM, Golbe LI, Hansson O, Karch CM, Kolb HC, La Joie R, Lee SE, Matallana D, Miller BL, Onyike CU, Quiroz YT, Rexach JE, Rohrer JD, Rommel A, Sadri-Vakili G, Schindler SE, Schneider JA, Sperling RA, Teunissen CE, Weninger SC, Worley SL, Zheng H, Carrillo MC. PMID: 38170841; PMCID: PMC10984447.
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PubMed Mentions:
5 Fields:
Translation:
Humans
-
Recent advances and future therapy development for Alzheimer's disease and related disorders. Neural Regen Res. 2024 Sep 01; 19(9):1877-1878.
Hong M, Bitan G. PMID: 38227506; PMCID: PMC11040305.
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PubMed Mentions:
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Characterization of Molecular Tweezer Binding on α-Synuclein with Native Top-Down Mass Spectrometry and Ion Mobility-Mass Spectrometry Reveals a Mechanism for Aggregation Inhibition. J Am Soc Mass Spectrom. 2023 Dec 06; 34(12):2739-2747.
Lantz C, Lopez J, Goring AK, Zenaidee MA, Biggs K, Whitelegge JP, Ogorzalek Loo RR, Klärner FG, Schrader T, Bitan G, Loo JA. PMID: 37936057; PMCID: PMC10959575.
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PubMed Mentions:
1 Fields:
Translation:
Humans
-
IM-MS and ECD-MS/MS Provide Insight into Modulation of Amyloid Proteins Self-Assembly by Peptides and Small Molecules. J Am Soc Mass Spectrom. 2023 Oct 04; 34(10):2066-2086.
Taha HB, Chawla E, Bitan G. PMID: 37607351.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Biomarkers for parkinsonian disorders in CNS-originating EVs: promise and challenges. Acta Neuropathol. 2023 05; 145(5):515-540.
Dutta S, Hornung S, Taha HB, Bitan G. PMID: 37012443; PMCID: PMC10071251.
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PubMed Mentions:
15 Fields:
Translation:
HumansCells
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Toward a biomarker panel measured in CNS-originating extracellular vesicles for improved differential diagnosis of Parkinson's disease and multiple system atrophy. Transl Neurodegener. 2023 03 20; 12(1):14.
Taha HB, Hornung S, Dutta S, Fenwick L, Lahgui O, Howe K, Elabed N, Del Rosario I, Wong DY, Duarte Folle A, Markovic D, Palma JA, Kang UJ, Alcalay RN, Sklerov M, Kaufmann H, Fogel BL, Bronstein JM, Ritz B, Bitan G. PMID: 36935518; PMCID: PMC10026428.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Development of a Novel Electrochemiluminescence ELISA for Quantification of α-Synuclein Phosphorylated at Ser129 in Biological Samples. ACS Chem Neurosci. 2023 04 05; 14(7):1238-1248.
Dutta S, Hornung S, Taha HB, Biggs K, Siddique I, Chamoun LM, Shahpasand-Kroner H, Lantz C, Herrera-Vaquero M, Stefanova N, Loo JA, Bitan G. PMID: 36920792; PMCID: PMC10080651.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimals
-
Editorial: Trends in biomarkers for neurodegenerative diseases: Current research and future perspectives. Front Aging Neurosci. 2023; 15:1153932.
Dutta S, Sklerov M, Teunissen CE, Bitan G. PMID: 36875706; PMCID: PMC9978689.
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PubMed Mentions:
1
-
Using FRET-Based Biosensor Cells to Study the Seeding Activity of Tau and α-Synuclein. Methods Mol Biol. 2023; 2551:125-145.
Maina KN, Smet-Nocca C, Bitan G. PMID: 36310201; PMCID: PMC9836052.
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PubMed Mentions:
3 Fields:
Translation:
Cells
-
Molecular Tweezers: Supramolecular Hosts with Broad-Spectrum Biological Applications. Pharmacol Rev. 2023 03; 75(2):263-308.
Shahpasand-Kroner H, Siddique I, Malik R, Linares GR, Ivanova MI, Ichida J, Weil T, Münch J, Sanchez-Garcia E, Klärner FG, Schrader T, Bitan G. PMID: 36549866; PMCID: PMC9976797.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
-
The Amyloid Inhibitor CLR01 Relieves Autophagy and Ameliorates Neuropathology in a Severe Lysosomal Storage Disease. Mol Ther. 2022 Nov 02; 30(11):3499.
Monaco A, Maffia V, Sorrentino NC, Sambri I, Ezhova Y, Giuliano T, Cacace V, Nusco E, De Risi M, De Leonibus E, Schrader T, Klärner FG, Bitan G, Fraldi A. PMID: 36261045; PMCID: PMC9637752.
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PubMed Mentions: Fields:
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A minute fraction of α-synuclein in extracellular vesicles may be a major contributor to α-synuclein spreading following autophagy inhibition. Front Mol Neurosci. 2022; 15:1001382.
Taha HB, Kearney B, Bitan G. PMID: 36245921; PMCID: PMC9554483.
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PubMed Mentions:
1
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Editorial: Exosomes: Message in a vesicle. Front Pharmacol. 2022; 13:1018928.
Dutta S, Nimse SB, Van Keuren-Jensen K, Bitan G. PMID: 36160457; PMCID: PMC9494591.
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PubMed Mentions:
1
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mTOR Inhibition with Sirolimus in Multiple System Atrophy: A Randomized, Double-Blind, Placebo-Controlled Futility Trial and 1-Year Biomarker Longitudinal Analysis. Mov Disord. 2022 04; 37(4):778-789.
Palma JA, Martinez J, Millar Vernetti P, Ma T, Perez MA, Zhong J, Qian Y, Dutta S, Maina KN, Siddique I, Bitan G, Ades-Aron B, Shepherd TM, Kang UJ, Kaufmann H. PMID: 35040506; PMCID: PMC9018525.
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PubMed Mentions:
11 Fields:
Translation:
Humans
-
Three-repeat and four-repeat tau isoforms form different oligomers. Protein Sci. 2022 03; 31(3):613-627.
Shahpasand-Kroner H, Portillo J, Lantz C, Seidler PM, Sarafian N, Loo JA, Bitan G. PMID: 34902187; PMCID: PMC8862439.
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PubMed Mentions:
7 Fields:
Translation:
Humans
-
Aptamers targeting amyloidogenic proteins and their emerging role in neurodegenerative diseases. J Biol Chem. 2022 01; 298(1):101478.
Murakami K, Izuo N, Bitan G. PMID: 34896392; PMCID: PMC8728582.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimals
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Lysine-selective molecular tweezers are cell penetrant and concentrate in lysosomes. Commun Biol. 2021 09 14; 4(1):1076.
Li Z, Siddique I, Hadrovic I, Kirupakaran A, Li J, Zhang Y, Klärner FG, Schrader T, Bitan G. PMID: 34521989; PMCID: PMC8440717.
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PubMed Mentions:
4 Translation:
HumansAnimalsCells
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α-Synuclein in blood exosomes immunoprecipitated using neuronal and oligodendroglial markers distinguishes Parkinson's disease from multiple system atrophy. Acta Neuropathol. 2021 09; 142(3):495-511.
Dutta S, Hornung S, Kruayatidee A, Maina KN, Del Rosario I, Paul KC, Wong DY, Duarte Folle A, Markovic D, Palma JA, Serrano GE, Adler CH, Perlman SL, Poon WW, Kang UJ, Alcalay RN, Sklerov M, Gylys KH, Kaufmann H, Fogel BL, Bronstein JM, Ritz B, Bitan G. PMID: 33991233; PMCID: PMC8357708.
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PubMed Mentions:
63 Fields:
Translation:
HumansCells
-
Inhibition of Staphylococcus aureus biofilm-forming functional amyloid by molecular tweezers. Cell Chem Biol. 2021 09 16; 28(9):1310-1320.e5.
Malishev R, Salinas N, Gibson J, Eden AB, Mieres-Perez J, Ruiz-Blanco YB, Malka O, Kolusheva S, Klärner FG, Schrader T, Sanchez-Garcia E, Wang C, Landau M, Bitan G, Jelinek R. PMID: 33852903; PMCID: PMC9377279.
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PubMed Mentions:
8 Fields:
Translation:
Cells
-
The molecular tweezer CLR01 improves behavioral deficits and reduces tau pathology in P301S-tau transgenic mice. Alzheimers Res Ther. 2021 01 04; 13(1):6.
Di J, Siddique I, Li Z, Malki G, Hornung S, Dutta S, Hurst I, Ishaaya E, Wang A, Tu S, Boghos A, Ericsson I, Klärner FG, Schrader T, Bitan G. PMID: 33397489; PMCID: PMC7784007.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Supramolecular Mechanism of Viral Envelope Disruption by Molecular Tweezers. J Am Chem Soc. 2020 10 07; 142(40):17024-17038.
Weil T, Groß R, Röcker A, Bravo-Rodriguez K, Heid C, Sowislok A, Le MH, Erwin N, Dwivedi M, Bart SM, Bates P, Wettstein L, Müller JA, Harms M, Sparrer K, Ruiz-Blanco YB, Stürzel CM, von Einem J, Lippold S, Read C, Walther P, Hebel M, Kreppel F, Klärner FG, Bitan G, Ehrmann M, Weil T, Winter R, Schrader T, Shorter J, Sanchez-Garcia E, Münch J. PMID: 32926779; PMCID: PMC7523239.
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PubMed Mentions:
18 Fields:
Translation:
HumansCells
-
CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson's disease. Nat Commun. 2020 09 28; 11(1):4885.
Bengoa-Vergniory N, Faggiani E, Ramos-Gonzalez P, Kirkiz E, Connor-Robson N, Brown LV, Siddique I, Li Z, Vingill S, Cioroch M, Cavaliere F, Threlfell S, Roberts B, Schrader T, Klärner FG, Cragg S, Dehay B, Bitan G, Matute C, Bezard E, Wade-Martins R. PMID: 32985503; PMCID: PMC7522721.
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PubMed Mentions:
30 Fields:
Translation:
HumansAnimalsCells
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Examination of SOD1 aggregation modulators and their effect on SOD1 enzymatic activity as a proxy for potential toxicity. FASEB J. 2020 09; 34(9):11957-11969.
Malik R, Corrales C, Linsenmeier M, Alalami H, Sepanj N, Bitan G. PMID: 32701214; PMCID: PMC7903925.
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PubMed Mentions:
4 Fields:
Translation:
Humans
-
Different Inhibitors of Aβ42-Induced Toxicity Have Distinct Metal-Ion Dependency. ACS Chem Neurosci. 2020 08 05; 11(15):2243-2255.
Mason AJ, Hurst I, Malik R, Siddique I, Solomonov I, Sagi I, Klärner FG, Schrader T, Bitan G. PMID: 32559370; PMCID: PMC7695034.
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PubMed Mentions:
2 Fields:
Translation:
Humans
-
The recent failure of the PROMESA clinical trial for multiple system atrophy raises the question-are polyphenols a viable therapeutic option against proteinopathies? Ann Transl Med. 2020 Jun; 8(11):719.
Bitan G. PMID: 32617339; PMCID: PMC7327354.
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PubMed Mentions:
4
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CNS-Derived Blood Exosomes as a Promising Source of Biomarkers: Opportunities and Challenges. Front Mol Neurosci. 2020; 13:38.
Hornung S, Dutta S, Bitan G. PMID: 32265650; PMCID: PMC7096580.
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PubMed Mentions:
95
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The Amyloid Inhibitor CLR01 Relieves Autophagy and Ameliorates Neuropathology in a Severe Lysosomal Storage Disease. Mol Ther. 2020 04 08; 28(4):1167-1176.
Monaco A, Maffia V, Sorrentino NC, Sambri I, Ezhova Y, Giuliano T, Cacace V, Nusco E, De Risi M, De Leonibus E, Schrader T, Klärner FG, Bitan G, Fraldi A. PMID: 32087148; PMCID: PMC7132627.
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PubMed Mentions:
24 Fields:
Translation:
AnimalsCells
-
Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation. Alzheimers Res Ther. 2019 10 18; 11(1):86.
Shin WS, Di J, Cao Q, Li B, Seidler PM, Murray KA, Bitan G, Jiang L. PMID: 31627745; PMCID: PMC6800506.
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PubMed Mentions:
33 Fields:
Translation:
HumansCells
-
Molecular Lysine Tweezers Counteract Aberrant Protein Aggregation. Front Chem. 2019; 7:657.
Hadrovic I, Rebmann P, Klärner FG, Bitan G, Schrader T. PMID: 31632951; PMCID: PMC6779714.
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PubMed Mentions:
10
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Ischemic axonal injury up-regulates MARK4 in cortical neurons and primes tau phosphorylation and aggregation. Acta Neuropathol Commun. 2019 08 20; 7(1):135.
Hayden EY, Putman J, Nunez S, Shin WS, Oberoi M, Charreton M, Dutta S, Li Z, Komuro Y, Joy MT, Bitan G, MacKenzie-Graham A, Jiang L, Hinman JD. PMID: 31429800; PMCID: PMC6700776.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Disease-modifying therapy for proteinopathies: Can the exception become the rule? Prog Mol Biol Transl Sci. 2019; 168:277-287.
Bitan G. PMID: 31699321; PMCID: PMC7032046.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimals
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The molecular tweezer CLR01 reduces aggregated, pathologic, and seeding-competent α-synuclein in experimental multiple system atrophy. Biochim Biophys Acta Mol Basis Dis. 2019 11 01; 1865(11):165513.
Herrera-Vaquero M, Bouquio D, Kallab M, Biggs K, Nair G, Ochoa J, Heras-Garvin A, Heid C, Hadrovic I, Poewe W, Wenning GK, Klärner FG, Schrader T, Bitan G, Stefanova N. PMID: 31319154; PMCID: PMC8425273.
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PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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Major Differences between the Self-Assembly and Seeding Behavior of Heparin-Induced and in Vitro Phosphorylated Tau and Their Modulation by Potential Inhibitors. ACS Chem Biol. 2019 06 21; 14(6):1363-1379.
Despres C, Di J, Cantrelle FX, Li Z, Huvent I, Chambraud B, Zhao J, Chen J, Chen S, Lippens G, Zhang F, Linhardt R, Wang C, Klärner FG, Schrader T, Landrieu I, Bitan G, Smet-Nocca C. PMID: 31046227; PMCID: PMC6636790.
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PubMed Mentions:
22 Fields:
Translation:
HumansAnimalsCells
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A Label-Free Platform for Identification of Exosomes from Different Sources. ACS Sens. 2019 02 22; 4(2):488-497.
Yan Z, Dutta S, Liu Z, Yu X, Mesgarzadeh N, Ji F, Bitan G, Xie YH. PMID: 30644736.
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PubMed Mentions:
51 Fields:
Translation:
AnimalsCells
-
The molecular tweezer CLR01 inhibits aberrant superoxide dismutase 1 (SOD1) self-assembly in vitro and in the G93A-SOD1 mouse model of ALS. J Biol Chem. 2019 03 08; 294(10):3501-3513.
Malik R, Meng H, Wongkongkathep P, Corrales CI, Sepanj N, Atlasi RS, Klärner FG, Schrader T, Spencer MJ, Loo JA, Wiedau M, Bitan G. PMID: 30602569; PMCID: PMC6416427.
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PubMed Mentions:
20 Fields:
Translation:
AnimalsCells
-
Investigation of Anti-SOD1 Antibodies Yields New Structural Insight into SOD1 Misfolding and Surprising Behavior of the Antibodies Themselves. ACS Chem Biol. 2018 09 21; 13(9):2794-2807.
Atlasi RS, Malik R, Corrales CI, Tzeplaeff L, Whitelegge JP, Cashman NR, Bitan G. PMID: 30110532; PMCID: PMC6475120.
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PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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Native Top-Down Mass Spectrometry and Ion Mobility Spectrometry of the Interaction of Tau Protein with a Molecular Tweezer Assembly Modulator. J Am Soc Mass Spectrom. 2019 Jan; 30(1):16-23.
Nshanian M, Lantz C, Wongkongkathep P, Schrader T, Klärner FG, Blümke A, Despres C, Ehrmann M, Smet-Nocca C, Bitan G, Loo JA. PMID: 30062477; PMCID: PMC6320309.
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PubMed Mentions:
25 Fields:
Translation:
Cells
-
The molecular tweezer CLR01 inhibits Ebola and Zika virus infection. Antiviral Res. 2018 04; 152:26-35.
Röcker AE, Müller JA, Dietzel E, Harms M, Krüger F, Heid C, Sowislok A, Riber CF, Kupke A, Lippold S, von Einem J, Beer J, Knöll B, Becker S, Schmidt-Chanasit J, Otto M, Vapalahti O, Zelikin AN, Bitan G, Schrader T, Münch J. PMID: 29428508; PMCID: PMC7113745.
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PubMed Mentions:
22 Fields:
Translation:
HumansAnimalsCells
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Using Molecular Tweezers to Remodel Abnormal Protein Self-Assembly and Inhibit the Toxicity of Amyloidogenic Proteins. Methods Mol Biol. 2018; 1777:369-386.
Malik R, Di J, Nair G, Attar A, Taylor K, Teng E, Klärner FG, Schrader T, Bitan G. PMID: 29744849; PMCID: PMC6459406.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Preparation of Pure Populations of Amyloid β-Protein Oligomers of Defined Size. Methods Mol Biol. 2018; 1779:3-12.
Hayden EY, Conovaloff JL, Mason A, Bitan G, Teplow DB. PMID: 29886523; PMCID: PMC6490168.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Recommendations of the Global Multiple System Atrophy Research Roadmap Meeting. Neurology. 2018 01 09; 90(2):74-82.
Walsh RR, Krismer F, Galpern WR, Wenning GK, Low PA, Halliday G, Koroshetz WJ, Holton J, Quinn NP, Rascol O, Shaw LM, Eidelberg D, Bower P, Cummings JL, Abler V, Biedenharn J, Bitan G, Brooks DJ, Brundin P, Fernandez H, Fortier P, Freeman R, Gasser T, Hewitt A, Höglinger GU, Huentelman MJ, Jensen PH, Jeromin A, Kang UJ, Kaufmann H, Kellerman L, Khurana V, Klockgether T, Kim WS, Langer C, LeWitt P, Masliah E, Meissner W, Melki R, Ostrowitzki S, Piantadosi S, Poewe W, Robertson D, Roemer C, Schenk D, Schlossmacher M, Schmahmann JD, Seppi K, Shih L, Siderowf A, Stebbins GT, Stefanova N, Tsuji S, Sutton S, Zhang J. PMID: 29237794; PMCID: PMC5772155.
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PubMed Mentions:
13 Fields:
Translation:
Humans
-
A Molecular Tweezer Ameliorates Motor Deficits in Mice Overexpressing α-Synuclein. Neurotherapeutics. 2017 Oct; 14(4):1107-1119.
Richter F, Subramaniam SR, Magen I, Lee P, Hayes J, Attar A, Zhu C, Franich NR, Bove N, De La Rosa K, Kwong J, Klärner FG, Schrader T, Chesselet MF, Bitan G. PMID: 28585223; PMCID: PMC5722755.
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PubMed Mentions:
27 Fields:
Translation:
HumansAnimalsCells
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Inhibition of Mutant αB Crystallin-Induced Protein Aggregation by a Molecular Tweezer. J Am Heart Assoc. 2017 Aug 08; 6(8).
Xu N, Bitan G, Schrader T, Klärner FG, Osinska H, Robbins J. PMID: 28862927; PMCID: PMC5586456.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Inhibition of Huntingtin Exon-1 Aggregation by the Molecular Tweezer CLR01. J Am Chem Soc. 2017 04 26; 139(16):5640-5643.
Vöpel T, Bravo-Rodriguez K, Mittal S, Vachharajani S, Gnutt D, Sharma A, Steinhof A, Fatoba O, Ellrichmann G, Nshanian M, Heid C, Loo JA, Klärner FG, Schrader T, Bitan G, Wanker EE, Ebbinghaus S, Sanchez-Garcia E. PMID: 28406616; PMCID: PMC5506490.
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PubMed Mentions:
18 Fields:
Translation:
HumansCells
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Computational On-Chip Imaging of Nanoparticles and Biomolecules using Ultraviolet Light. Sci Rep. 2017 03 09; 7:44157.
Daloglu MU, Ray A, Gorocs Z, Xiong M, Malik R, Bitan G, McLeod E, Ozcan A. PMID: 28276489; PMCID: PMC5343455.
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PubMed Mentions:
7 Fields:
Translation:
Humans
-
Preparation of pure populations of covalently stabilized amyloid β-protein oligomers of specific sizes. Anal Biochem. 2017 Feb 01; 518:78-85.
Hayden EY, Conovaloff JL, Mason A, Bitan G, Teplow DB. PMID: 27810329; PMCID: PMC5474095.
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PubMed Mentions:
16 Fields:
Translation:
Humans
-
Molecular tweezers for lysine and arginine - powerful inhibitors of pathologic protein aggregation. Chem Commun (Camb). 2016 Oct 15; 52(76):11318-34.
Schrader T, Bitan G, Klärner FG. PMID: 27546596; PMCID: PMC5026632.
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PubMed Mentions:
40 Fields:
Translation:
HumansAnimals
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Modulation of Amyloid β-Protein (Aβ) Assembly by Homologous C-Terminal Fragments as a Strategy for Inhibiting Aβ Toxicity. ACS Chem Neurosci. 2016 07 20; 7(7):845-56.
Li H, Rahimi F, Bitan G. PMID: 27322435; PMCID: PMC5450937.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Neurotoxicity of the Parkinson Disease-Associated Pesticide Ziram Is Synuclein-Dependent in Zebrafish Embryos. Environ Health Perspect. 2016 Nov; 124(11):1766-1775.
Lulla A, Barnhill L, Bitan G, Ivanova MI, Nguyen B, O'Donnell K, Stahl MC, Yamashiro C, Klärner FG, Schrader T, Sagasti A, Bronstein JM. PMID: 27301718; PMCID: PMC5089875.
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PubMed Mentions:
32 Fields:
Translation:
AnimalsCells
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Reducing synuclein accumulation improves neuronal survival after spinal cord injury. Exp Neurol. 2016 Apr; 278:105-15.
Fogerson SM, van Brummen AJ, Busch DJ, Allen SR, Roychaudhuri R, Banks SM, Klärner FG, Schrader T, Bitan G, Morgan JR. PMID: 26854933; PMCID: PMC4788542.
View in:
PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
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Role of Species-Specific Primary Structure Differences in Aβ42 Assembly and Neurotoxicity. ACS Chem Neurosci. 2015 Dec 16; 6(12):1941-55.
Roychaudhuri R, Zheng X, Lomakin A, Maiti P, Condron MM, Benedek GB, Bitan G, Bowers MT, Teplow DB. PMID: 26421877; PMCID: PMC4844016.
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PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
-
Mechanism of C-Terminal Fragments of Amyloid β-Protein as Aβ Inhibitors: Do C-Terminal Interactions Play a Key Role in Their Inhibitory Activity? J Phys Chem B. 2016 Mar 03; 120(8):1615-23.
Zheng X, Wu C, Liu D, Li H, Bitan G, Shea JE, Bowers MT. PMID: 26439281; PMCID: PMC4777659.
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PubMed Mentions:
20 Fields:
Translation:
HumansCells
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Toxicity inhibitors protect lipid membranes from disruption by Aβ42. ACS Chem Neurosci. 2015 Nov 18; 6(11):1860-9.
Malishev R, Nandi S, Kolusheva S, Levi-Kalisman Y, Klärner FG, Schrader T, Bitan G, Jelinek R. PMID: 26317327.
View in:
PubMed Mentions:
6 Fields:
Translation:
Cells
-
A molecular tweezer antagonizes seminal amyloids and HIV infection. Elife. 2015 Aug 18; 4.
Lump E, Castellano LM, Meier C, Seeliger J, Erwin N, Sperlich B, Stürzel CM, Usmani S, Hammond RM, von Einem J, Gerold G, Kreppel F, Bravo-Rodriguez K, Pietschmann T, Holmes VM, Palesch D, Zirafi O, Weissman D, Sowislok A, Wettig B, Heid C, Kirchhoff F, Weil T, Klärner FG, Schrader T, Bitan G, Sanchez-Garcia E, Winter R, Shorter J, Münch J. PMID: 26284498; PMCID: PMC4536748.
View in:
PubMed Mentions:
41 Fields:
Translation:
HumansPHPublic Health
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The Lys-Specific Molecular Tweezer, CLR01, Modulates Aggregation of the Mutant p53 DNA Binding Domain and Inhibits Its Toxicity. Biochemistry. 2015 Jun 23; 54(24):3729-38.
Herzog G, Shmueli MD, Levy L, Engel L, Gazit E, Klärner FG, Schrader T, Bitan G, Segal D. PMID: 26030124.
View in:
PubMed Mentions:
17 Fields:
Translation:
HumansCells
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Molecular tweezers inhibit islet amyloid polypeptide assembly and toxicity by a new mechanism. ACS Chem Biol. 2015 Jun 19; 10(6):1555-69.
Lopes DH, Attar A, Nair G, Hayden EY, Du Z, McDaniel K, Dutt S, Bravo-Rodriguez K, Mittal S, Klärner FG, Wang C, Sanchez-Garcia E, Schrader T, Bitan G. PMID: 25844890.
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PubMed Mentions:
25 Fields:
Translation:
HumansAnimalsCells
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Amyloid β-protein assembly: The effect of molecular tweezers CLR01 and CLR03. J Phys Chem B. 2015 Apr 09; 119(14):4831-41.
Zheng X, Liu D, Klärner FG, Schrader T, Bitan G, Bowers MT. PMID: 25751170; PMCID: PMC4415044.
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PubMed Mentions:
31 Fields:
Translation:
Cells
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Exact modeling of cylindrical metal-dielectric multilayers beyond the effective medium approximation. Opt Lett. 2014 Nov 15; 39(22):6517-20.
Aronovich D, Bitan G, Bartal G. PMID: 25490508.
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PubMed Mentions: Fields:
-
Safety and pharmacological characterization of the molecular tweezer CLR01 - a broad-spectrum inhibitor of amyloid proteins' toxicity. BMC Pharmacol Toxicol. 2014 Apr 16; 15:23.
Attar A, Chan WT, Klärner FG, Schrader T, Bitan G. PMID: 24735982; PMCID: PMC3996151.
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PubMed Mentions:
27 Fields:
Translation:
Animals
-
Molecular tweezers targeting transthyretin amyloidosis. Neurotherapeutics. 2014 Apr; 11(2):450-61.
Ferreira N, Pereira-Henriques A, Attar A, Klärner FG, Schrader T, Bitan G, Gales L, Saraiva MJ, Almeida MR. PMID: 24459092; PMCID: PMC3996111.
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PubMed Mentions:
28 Fields:
Translation:
HumansAnimalsCells
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Molecular basis for preventing α-synuclein aggregation by a molecular tweezer. J Biol Chem. 2014 Apr 11; 289(15):10727-10737.
Acharya S, Safaie BM, Wongkongkathep P, Ivanova MI, Attar A, Klärner FG, Schrader T, Loo JA, Bitan G, Lapidus LJ. PMID: 24567327; PMCID: PMC4036189.
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PubMed Mentions:
50 Fields:
Translation:
HumansCells
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Disrupting self-assembly and toxicity of amyloidogenic protein oligomers by "molecular tweezers" - from the test tube to animal models. Curr Pharm Des. 2014; 20(15):2469-83.
Attar A, Bitan G. PMID: 23859557; PMCID: PMC4261945.
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PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
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A shortened Barnes maze protocol reveals memory deficits at 4-months of age in the triple-transgenic mouse model of Alzheimer's disease. PLoS One. 2013; 8(11):e80355.
Attar A, Liu T, Chan WT, Hayes J, Nejad M, Lei K, Bitan G. PMID: 24236177; PMCID: PMC3827415.
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PubMed Mentions:
66 Fields:
Translation:
Animals
-
Tranilast binds to aβ monomers and promotes aβ fibrillation. Biochemistry. 2013 Jun 11; 52(23):3995-4002.
Connors CR, Rosenman DJ, Lopes DH, Mittal S, Bitan G, Sorci M, Belfort G, Garcia A, Wang C. PMID: 23679559; PMCID: PMC4082028.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers. Brain. 2012 Dec; 135(Pt 12):3735-48.
Attar A, Ripoli C, Riccardi E, Maiti P, Li Puma DD, Liu T, Hayes J, Jones MR, Lichti-Kaiser K, Yang F, Gale GD, Tseng CH, Tan M, Xie CW, Straudinger JL, Klärner FG, Schrader T, Frautschy SA, Grassi C, Bitan G. PMID: 23183235; PMCID: PMC3525056.
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PubMed Mentions:
45 Fields:
Translation:
AnimalsCells
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Effects of different amyloid β-protein analogues on synaptic function. Neurobiol Aging. 2013 Apr; 34(4):1032-44.
Ripoli C, Piacentini R, Riccardi E, Leone L, Li Puma DD, Bitan G, Grassi C. PMID: 23046860.
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PubMed Mentions:
37 Fields:
Translation:
AnimalsCells
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Plasma methionine sulfoxide in persons with familial Alzheimer's disease mutations. Dement Geriatr Cogn Disord. 2012; 33(4):219-25.
Ringman JM, Fithian AT, Gylys K, Cummings JL, Coppola G, Elashoff D, Pratico D, Moskovitz J, Bitan G. PMID: 22584618; PMCID: PMC3568669.
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PubMed Mentions:
8 Fields:
Translation:
Humans
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Zn2+-Aβ40 complexes form metastable quasi-spherical oligomers that are cytotoxic to cultured hippocampal neurons. J Biol Chem. 2012 Jun 08; 287(24):20555-64.
Solomonov I, Korkotian E, Born B, Feldman Y, Bitler A, Rahimi F, Li H, Bitan G, Sagi I. PMID: 22528492; PMCID: PMC3370240.
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PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
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A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo. Neurotherapeutics. 2012 Apr; 9(2):464-76.
Prabhudesai S, Sinha S, Attar A, Kotagiri A, Fitzmaurice AG, Lakshmanan R, Lakshmanan R, Ivanova MI, Loo JA, Klärner FG, Schrader T, Stahl M, Bitan G, Bronstein JM. PMID: 22373667; PMCID: PMC3337029.
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PubMed Mentions:
74 Fields:
Translation:
HumansAnimalsCells
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A key role for lysine residues in amyloid β-protein folding, assembly, and toxicity. ACS Chem Neurosci. 2012 Jun 20; 3(6):473-81.
Sinha S, Lopes DH, Bitan G. PMID: 22860216; PMCID: PMC3382451.
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PubMed Mentions:
41 Fields:
Translation:
AnimalsCells
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Design of β-amyloid aggregation inhibitors from a predicted structural motif. J Med Chem. 2012 Apr 12; 55(7):3002-10.
Novick PA, Lopes DH, Branson KM, Esteras-Chopo A, Graef IA, Bitan G, Pande VS. PMID: 22420626; PMCID: PMC3766731.
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PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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Comparison of three amyloid assembly inhibitors: the sugar scyllo-inositol, the polyphenol epigallocatechin gallate, and the molecular tweezer CLR01. ACS Chem Neurosci. 2012 Jun 20; 3(6):451-8.
Sinha S, Du Z, Maiti P, Klärner FG, Schrader T, Wang C, Bitan G. PMID: 22860214; PMCID: PMC3386858.
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PubMed Mentions:
49 Fields:
Translation:
Animals
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Modulating self-assembly of amyloidogenic proteins as a therapeutic approach for neurodegenerative diseases: strategies and mechanisms. ChemMedChem. 2012 Mar 05; 7(3):359-74.
Liu T, Bitan G. PMID: 22323134.
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PubMed Mentions:
28 Fields:
Translation:
HumansAnimalsCells
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A two-step strategy for structure-activity relationship studies of N-methylated aβ42 C-terminal fragments as aβ42 toxicity inhibitors. ChemMedChem. 2012 Mar 05; 7(3):515-22.
Li H, Zemel R, Lopes DH, Monien BH, Bitan G. PMID: 22307963; PMCID: PMC3517043.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Application of photochemical cross-linking to the study of oligomerization of amyloidogenic proteins. Methods Mol Biol. 2012; 849:11-21.
Lopes DH, Sinha S, Rosensweig C, Bitan G. PMID: 22528080.
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PubMed Mentions:
9 Fields:
Translation:
Cells
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Preparation of stable amyloid β-protein oligomers of defined assembly order. Methods Mol Biol. 2012; 849:23-31.
Rosensweig C, Ono K, Murakami K, Lowenstein DK, Bitan G, Teplow DB. PMID: 22528081; PMCID: PMC5767166.
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PubMed Mentions:
10 Fields:
Translation:
Cells
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Aβ(39-42) modulates Aβ oligomerization but not fibril formation. Biochemistry. 2012 Jan 10; 51(1):108-17.
Gessel MM, Wu C, Li H, Bitan G, Shea JE, Bowers MT. PMID: 22129303; PMCID: PMC3271797.
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PubMed Mentions:
34 Fields:
Translation:
HumansAnimalsCells
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C-terminal tetrapeptides inhibit Aβ42-induced neurotoxicity primarily through specific interaction at the N-terminus of Aβ42. J Med Chem. 2011 Dec 22; 54(24):8451-60.
Li H, Du Z, Lopes DH, Fradinger EA, Wang C, Bitan G. PMID: 22087474; PMCID: PMC3240737.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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Induction of methionine-sulfoxide reductases protects neurons from amyloid β-protein insults in vitro and in vivo. Biochemistry. 2011 Dec 13; 50(49):10687-97.
Moskovitz J, Maiti P, Lopes DH, Oien DB, Attar A, Liu T, Mittal S, Hayes J, Bitan G. PMID: 22059533; PMCID: PMC3235361.
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PubMed Mentions:
21 Fields:
Translation:
AnimalsCells
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Lysine-specific molecular tweezers are broad-spectrum inhibitors of assembly and toxicity of amyloid proteins. J Am Chem Soc. 2011 Oct 26; 133(42):16958-69.
Sinha S, Lopes DH, Du Z, Pang ES, Shanmugam A, Lomakin A, Talbiersky P, Tennstaedt A, McDaniel K, Bakshi R, Kuo PY, Ehrmann M, Benedek GB, Loo JA, Klärner FG, Schrader T, Wang C, Bitan G. PMID: 21916458; PMCID: PMC3210512.
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PubMed Mentions:
108 Fields:
Translation:
AnimalsCells
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Structural basis for Aβ1–42 toxicity inhibition by Aβ C-terminal fragments: discrete molecular dynamics study. J Mol Biol. 2011 Jul 08; 410(2):316-28.
Urbanc B, Betnel M, Cruz L, Li H, Fradinger EA, Monien BH, Bitan G. PMID: 21621545; PMCID: PMC3124842.
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PubMed Mentions:
19 Fields:
Translation:
HumansCells
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Rational design of β-sheet ligands against Aβ42-induced toxicity. J Am Chem Soc. 2011 Mar 30; 133(12):4348-58.
Hochdörffer K, März-Berberich J, Nagel-Steger L, Epple M, Meyer-Zaika W, Horn AH, Sticht H, Sinha S, Bitan G, Schrader T. PMID: 21381732.
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PubMed Mentions:
12 Fields:
Translation:
Cells
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Surprising toxicity and assembly behaviour of amyloid β-protein oxidized to sulfone. Biochem J. 2011 Jan 15; 433(2):323-32.
Maiti P, Piacentini R, Ripoli C, Grassi C, Bitan G. PMID: 21044048; PMCID: PMC5767168.
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PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
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Mechanistic investigation of the inhibition of Abeta42 assembly and neurotoxicity by Abeta42 C-terminal fragments. Biochemistry. 2010 Aug 03; 49(30):6358-64.
Li H, Monien BH, Lomakin A, Zemel R, Fradinger EA, Tan M, Spring SM, Urbanc B, Xie CW, Benedek GB, Bitan G. PMID: 20568734; PMCID: PMC2912417.
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PubMed Mentions:
17 Fields:
Translation:
HumansCells
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Selection of aptamers for amyloid beta-protein, the causative agent of Alzheimer's disease. J Vis Exp. 2010 May 13; (39).
Rahimi F, Bitan G. PMID: 20616783; PMCID: PMC2918391.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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Elucidation of amyloid beta-protein oligomerization mechanisms: discrete molecular dynamics study. J Am Chem Soc. 2010 Mar 31; 132(12):4266-80.
Urbanc B, Betnel M, Cruz L, Bitan G, Teplow DB. PMID: 20218566; PMCID: PMC5767167.
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PubMed Mentions:
82 Fields:
Translation:
Cells
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Despite its role in assembly, methionine 35 is not necessary for amyloid beta-protein toxicity. J Neurochem. 2010 Jun; 113(5):1252-62.
Maiti P, Lomakin A, Benedek GB, Bitan G. PMID: 20345758; PMCID: PMC2908238.
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PubMed Mentions:
21 Fields:
Translation:
AnimalsCells
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Biophysical characterization of Abeta42 C-terminal fragments: inhibitors of Abeta42 neurotoxicity. Biochemistry. 2010 Feb 16; 49(6):1259-67.
Li H, Monien BH, Fradinger EA, Urbanc B, Bitan G. PMID: 20050679; PMCID: PMC2831638.
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PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
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RNA aptamers generated against oligomeric Abeta40 recognize common amyloid aptatopes with low specificity but high sensitivity. PLoS One. 2009 Nov 10; 4(11):e7694.
Rahimi F, Murakami K, Summers JL, Chen CH, Bitan G. PMID: 19901993; PMCID: PMC2770325.
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PubMed Mentions:
27 Fields:
Translation:
HumansCells
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Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease. Nat Chem. 2009 Jul; 1(4):326-31.
Bernstein SL, Dupuis NF, Lazo ND, Wyttenbach T, Condron MM, Bitan G, Teplow DB, Shea JE, Ruotolo BT, Robinson CV, Bowers MT. PMID: 20703363; PMCID: PMC2918915.
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PubMed Mentions:
361 Fields:
Translation:
Humans
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Amino acid position-specific contributions to amyloid beta-protein oligomerization. J Biol Chem. 2009 Aug 28; 284(35):23580-91.
Maji SK, Ogorzalek Loo RR, Inayathullah M, Spring SM, Vollers SS, Condron MM, Bitan G, Loo JA, Teplow DB. PMID: 19567875; PMCID: PMC2749133.
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PubMed Mentions:
43 Fields:
Translation:
HumansCells
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The structure of Abeta42 C-terminal fragments probed by a combined experimental and theoretical study. J Mol Biol. 2009 Mar 27; 387(2):492-501.
Wu C, Murray MM, Bernstein SL, Condron MM, Bitan G, Shea JE, Bowers MT. PMID: 19356595; PMCID: PMC2712569.
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PubMed Mentions:
27 Fields:
Translation:
Cells
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Photo-induced cross-linking of unmodified proteins (PICUP) applied to amyloidogenic peptides. J Vis Exp. 2009 Jan 12; (23).
Rahimi F, Maiti P, Bitan G. PMID: 19229175; PMCID: PMC2763294.
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PubMed Mentions:
51 Fields:
Translation:
HumansCells
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C-terminal peptides coassemble into Abeta42 oligomers and protect neurons against Abeta42-induced neurotoxicity. Proc Natl Acad Sci U S A. 2008 Sep 16; 105(37):14175-80.
Fradinger EA, Monien BH, Urbanc B, Lomakin A, Tan M, Li H, Spring SM, Condron MM, Cruz L, Xie CW, Benedek GB, Bitan G. PMID: 18779585; PMCID: PMC2544597.
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PubMed Mentions:
60 Fields:
Translation:
AnimalsCells
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Structure-function relationships of pre-fibrillar protein assemblies in Alzheimer's disease and related disorders. Curr Alzheimer Res. 2008 Jun; 5(3):319-41.
Rahimi F, Shanmugam A, Bitan G. PMID: 18537546; PMCID: PMC2835858.
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PubMed Mentions:
42 Fields:
Translation:
HumansAnimalsCells
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Synthesis and Purification of Highly Hydrophobic Peptides Derived from the C-Terminus of Amyloid β-Protein. Open Biotechnol J. 2008 Jan 01; 2(1):87-93.
Condron MM, Monien BH, Bitan G. PMID: 19898686; PMCID: PMC2773559.
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PubMed Mentions:
16
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Role of electrostatic interactions in amyloid beta-protein (A beta) oligomer formation: a discrete molecular dynamics study. Biophys J. 2007 Jun 01; 92(11):4064-77.
Yun S, Urbanc B, Cruz L, Bitan G, Teplow DB, Stanley HE. PMID: 17307823; PMCID: PMC1868995.
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PubMed Mentions:
47 Fields:
Translation:
Cells
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Early diagnostics and therapeutics for Alzheimer's disease--how early can we get there? Expert Rev Neurother. 2006 Sep; 6(9):1293-306.
Monien BH, Apostolova LG, Bitan G. PMID: 17009917; PMCID: PMC2715564.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimals
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Elucidating amyloid beta-protein folding and assembly: A multidisciplinary approach. Acc Chem Res. 2006 Sep; 39(9):635-45.
Teplow DB, Lazo ND, Bitan G, Bernstein S, Wyttenbach T, Bowers MT, Baumketner A, Shea JE, Urbanc B, Cruz L, Borreguero J, Stanley HE. PMID: 16981680.
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PubMed Mentions:
81 Fields:
Translation:
Cells
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Dendrimeric Abeta1-15 is an effective immunogen in wildtype and APP-tg mice. Neurobiol Aging. 2007 Jun; 28(6):813-23.
Seabrook TJ, Thomas K, Jiang L, Bloom J, Spooner E, Maier M, Bitan G, Lemere CA. PMID: 16725229.
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PubMed Mentions:
27 Fields:
Translation:
HumansAnimals
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Amyloid beta-protein monomer structure: a computational and experimental study. Protein Sci. 2006 Mar; 15(3):420-8.
Baumketner A, Bernstein SL, Wyttenbach T, Bitan G, Teplow DB, Bowers MT, Shea JE. PMID: 16501222; PMCID: PMC2249763.
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PubMed Mentions:
86 Fields:
Translation:
Cells
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Structural study of metastable amyloidogenic protein oligomers by photo-induced cross-linking of unmodified proteins. Methods Enzymol. 2006; 413:217-36.
Bitan G. PMID: 17046399; PMCID: PMC2782599.
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PubMed Mentions:
45 Fields:
Translation:
Cells
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En route to early diagnosis of Alzheimer's disease--are we there yet? Trends Biotechnol. 2005 Nov; 23(11):531-3.
Fradinger EA, Bitan G. PMID: 16165236.
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PubMed Mentions:
7 Fields:
Translation:
HumansCells
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Neurotoxic protein oligomers--what you see is not always what you get. Amyloid. 2005 Jun; 12(2):88-95.
Bitan G, Fradinger EA, Spring SM, Teplow DB. PMID: 16011984.
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PubMed Mentions:
98 Fields:
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Amyloid beta-protein: monomer structure and early aggregation states of Abeta42 and its Pro19 alloform. J Am Chem Soc. 2005 Feb 23; 127(7):2075-84.
Bernstein SL, Wyttenbach T, Baumketner A, Shea JE, Bitan G, Teplow DB, Bowers MT. PMID: 15713083.
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PubMed Mentions:
125 Fields:
Translation:
Cells
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Determination of Peptide oligomerization state using rapid photochemical crosslinking. Methods Mol Biol. 2005; 299:11-8.
Vollers SS, Teplow DB, Bitan G. PMID: 15980592.
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PubMed Mentions:
14 Fields:
Translation:
Cells
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Preparation of aggregate-free, low molecular weight amyloid-beta for assembly and toxicity assays. Methods Mol Biol. 2005; 299:3-9.
Bitan G, Teplow DB. PMID: 15980591.
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PubMed Mentions:
29 Fields:
Translation:
Humans
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In silico study of amyloid beta-protein folding and oligomerization. Proc Natl Acad Sci U S A. 2004 Dec 14; 101(50):17345-50.
Urbanc B, Cruz L, Yun S, Buldyrev SV, Bitan G, Teplow DB, Stanley HE. PMID: 15583128; PMCID: PMC536046.
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PubMed Mentions:
108 Fields:
Translation:
Cells
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Rapid photochemical cross-linking--a new tool for studies of metastable, amyloidogenic protein assemblies. Acc Chem Res. 2004 Jun; 37(6):357-64.
Bitan G, Teplow DB. PMID: 15196045.
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PubMed Mentions:
85 Fields:
Translation:
Cells
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A molecular switch in amyloid assembly: Met35 and amyloid beta-protein oligomerization. J Am Chem Soc. 2003 Dec 17; 125(50):15359-65.
Bitan G, Tarus B, Vollers SS, Lashuel HA, Condron MM, Straub JE, Teplow DB. PMID: 14664580.
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PubMed Mentions:
60 Fields:
Translation:
Cells
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Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease. J Clin Invest. 2003 Aug; 112(3):415-22.
Monsonego A, Zota V, Karni A, Krieger JI, Bar-Or A, Bitan G, Budson AE, Sperling R, Selkoe DJ, Weiner HL. PMID: 12897209; PMCID: PMC166296.
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PubMed Mentions:
137 Fields:
Translation:
HumansAnimalsCells
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Elucidation of primary structure elements controlling early amyloid beta-protein oligomerization. J Biol Chem. 2003 Sep 12; 278(37):34882-9.
Bitan G, Vollers SS, Teplow DB. PMID: 12840029.
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PubMed Mentions:
100 Fields:
Translation:
HumansCells
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Amyloid beta -protein (Abeta) assembly: Abeta 40 and Abeta 42 oligomerize through distinct pathways. Proc Natl Acad Sci U S A. 2003 Jan 07; 100(1):330-5.
Bitan G, Kirkitadze MD, Lomakin A, Vollers SS, Benedek GB, Teplow DB. PMID: 12506200; PMCID: PMC140968.
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PubMed Mentions:
444 Fields:
Translation:
Humans
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Polyglutamine repeat length-dependent proteolysis of huntingtin. Neurobiol Dis. 2002 Oct; 11(1):111-22.
Sun B, Fan W, Balciunas A, Cooper JK, Bitan G, Steavenson S, Denis PE, Young Y, Adler B, Daugherty L, Manoukian R, Elliott G, Shen W, Talvenheimo J, Teplow DB, Haniu M, Haldankar R, Wypych J, Ross CA, Citron M, Richards WG. PMID: 12460551.
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PubMed Mentions:
21 Fields:
Translation:
AnimalsCells
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Paradigm shifts in Alzheimer's disease and other neurodegenerative disorders: the emerging role of oligomeric assemblies. J Neurosci Res. 2002 Sep 01; 69(5):567-77.
Kirkitadze MD, Bitan G, Teplow DB. PMID: 12210822.
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PubMed Mentions:
218 Fields:
Translation:
HumansAnimalsCells
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Identification of a contact domain between echistatin and the integrin alpha(v)beta(3) by photoaffinity cross-linking. Biochemistry. 2001 Dec 18; 40(50):15117-26.
Scheibler L, Mierke DF, Bitan G, Rosenblatt M, Chorev M. PMID: 11735394.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Amyloid beta-protein oligomerization: prenucleation interactions revealed by photo-induced cross-linking of unmodified proteins. J Biol Chem. 2001 Sep 14; 276(37):35176-84.
Bitan G, Lomakin A, Teplow DB. PMID: 11441003.
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PubMed Mentions:
138 Fields:
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The relationship between homology length and crossing over during the repair of a broken chromosome. J Biol Chem. 2000 Oct 06; 275(40):30833-8.
Inbar O, Liefshitz B, Bitan G, Kupiec M. PMID: 10924495.
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PubMed Mentions:
35 Fields:
Translation:
AnimalsCells
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Ligand-integrin alpha v beta 3 interaction determined by photoaffinity cross-linking: a challenge to the prevailing model. Biochemistry. 2000 Sep 12; 39(36):11014-23.
Bitan G, Scheibler L, Mierke DF, Rosenblatt M, Chorev M. PMID: 10998238.
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PubMed Mentions: Fields:
Translation:
HumansCells
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Design and evaluation of benzophenone-containing conformationally constrained ligands as tools for photoaffinity scanning of the integrin alphaVbeta3-ligand bimolecular interaction. J Pept Res. 2000 Mar; 55(3):181-94.
Bitan G, Scheibler L, Teng H, Rosenblatt M, Chorev M. PMID: 10727100.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Photoaffinity cross-linking identifies differences in the interactions of an agonist and an antagonist with the parathyroid hormone/parathyroid hormone-related protein receptor. J Biol Chem. 2000 Jan 07; 275(1):9-17.
Behar V, Bisello A, Bitan G, Rosenblatt M, Chorev M. PMID: 10617579.
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PubMed Mentions:
23 Fields:
Translation:
HumansAnimalsCells
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Mapping the integrin alpha V beta 3-ligand interface by photoaffinity cross-linking. Biochemistry. 1999 Mar 16; 38(11):3414-20.
Bitan G, Scheibler L, Greenberg Z, Rosenblatt M, Chorev M. PMID: 10079087.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Synthesis and biological activity of novel backbone-bicyclic substance-P analogs containing lactam and disulfide bridges. J Pept Res. 1997 May; 49(5):421-6.
Bitan G, Sukhotinsky I, Mashriki Y, Hanani M, Selinger Z, Gilon C. PMID: 9211223.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Building Units for N-Backbone Cyclic Peptides. 3. Synthesis of Protected N(alpha)-(omega-Aminoalkyl)amino Acids and N(alpha)-(omega-Carboxyalkyl)amino Acids. J Org Chem. 1997 Jan 24; 62(2):411-416.
Muller D, Zeltser I, Bitan G, Gilon C. PMID: 11671417.
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PubMed Mentions:
5 Fields:
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Structure-activity relationship of the ring portion in backbone-cyclic C-terminal hexapeptide analogs of substance P. NMR and molecular dynamics. Int J Pept Protein Res. 1996 Dec; 48(6):569-79.
Behrens S, Mathä B, Bitan G, Gilon C, Kessler H. PMID: 8985790.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Synthesis and biological activity of NK-1 selective, N-backbone cyclic analogs of the C-terminal hexapeptide of substance P. J Med Chem. 1996 Aug 02; 39(16):3174-8.
Byk G, Halle D, Zeltser I, Bitan G, Selinger Z, Gilon C. PMID: 8759639.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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Backbone cyclization of the C-terminal part of substance P. Part 1: The important role of the sulphur in position 11. J Pept Sci. 1996 Jul-Aug; 2(4):261-9.
Bitan G, Zeltser I, Byk G, Halle D, Mashriki Y, Gluhov EV, Sukhotinsky I, Hanani M, Selinger Z, Gilon C. PMID: 9231334.
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PubMed Mentions: Fields:
Translation:
AnimalsCells