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Bitan, Gal

Title(s)Professor-in-Residence, Neurology
Phone62082
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    Collapse Research 
    Collapse Research Activities and Funding
    Investigation of the effect of structural modifications of tau on assembly state and seeding
    NIH/NIA R01AG054000Jul 15, 2017 - May 31, 2022
    Role: Principal Investigator
    Misfolded protein clearance enhancers for Alzheimers therapy
    NIH/NIA R01AG050721Sep 15, 2015 - Apr 30, 2020
    Role: Principal Investigator
    Novel Specific Ligands for ABeta Oligomers
    NIH/NIA R21AG030709Sep 1, 2007 - May 31, 2010
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Monaco A, Maffia V, Sorrentino NC, Sambri I, Ezhova Y, Giuliano T, Cacace V, Nusco E, De Risi M, De Leonibus E, Schrader T, Klärner FG, Bitan G, Fraldi A. The Amyloid Inhibitor CLR01 Relieves Autophagy and Ameliorates Neuropathology in a Severe Lysosomal Storage Disease. Mol Ther. 2020 Feb 12. PMID: 32087148.
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    2. Shin WS, Di J, Murray KA, Sun C, Li B, Bitan G, Jiang L. Different Amyloid-ß Self-Assemblies Have Distinct Effects on Intracellular Tau Aggregation. Front Mol Neurosci. 2019; 12:268. PMID: 31787880.
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    3. Hadrovic I, Rebmann P, Klärner FG, Bitan G, Schrader T. Molecular Lysine Tweezers Counteract Aberrant Protein Aggregation. Front Chem. 2019; 7:657. PMID: 31632951.
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    4. Bitan G. Disease-modifying therapy for proteinopathies: Can the exception become the rule? Prog Mol Biol Transl Sci. 2019; 168:277-287. PMID: 31699321.
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    5. Herrera-Vaquero M, Bouquio D, Kallab M, Biggs K, Nair G, Ochoa J, Heras-Garvin A, Heid C, Hadrovic I, Poewe W, Wenning GK, Klärner FG, Schrader T, Bitan G, Stefanova N. The molecular tweezer CLR01 reduces aggregated, pathologic, and seeding-competent a-synuclein in experimental multiple system atrophy. Biochim Biophys Acta Mol Basis Dis. 2019 Nov 01; 1865(11):165513. PMID: 31319154.
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    6. Despres C, Di J, Cantrelle FX, Li Z, Huvent I, Chambraud B, Zhao J, Chen J, Chen S, Lippens G, Zhang F, Linhardt R, Wang C, Klärner FG, Schrader T, Landrieu I, Bitan G, Smet-Nocca C. Major Differences between the Self-Assembly and Seeding Behavior of Heparin-Induced and in Vitro Phosphorylated Tau and Their Modulation by Potential Inhibitors. ACS Chem Biol. 2019 06 21; 14(6):1363-1379. PMID: 31046227.
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    7. Malik R, Meng H, Wongkongkathep P, Corrales CI, Sepanj N, Atlasi RS, Klärner FG, Schrader T, Spencer MJ, Loo JA, Wiedau M, Bitan G. The molecular tweezer CLR01 inhibits aberrant superoxide dismutase 1 (SOD1) self-assembly in vitro and in the G93A-SOD1 mouse model of ALS. J Biol Chem. 2019 03 08; 294(10):3501-3513. PMID: 30602569.
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    8. Nshanian M, Lantz C, Wongkongkathep P, Schrader T, Klärner FG, Blümke A, Despres C, Ehrmann M, Smet-Nocca C, Bitan G, Loo JA. Native Top-Down Mass Spectrometry and Ion Mobility Spectrometry of the Interaction of Tau Protein with a Molecular Tweezer Assembly Modulator. J Am Soc Mass Spectrom. 2019 Jan; 30(1):16-23. PMID: 30062477.
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    9. Röcker AE, Müller JA, Dietzel E, Harms M, Krüger F, Heid C, Sowislok A, Riber CF, Kupke A, Lippold S, von Einem J, Beer J, Knöll B, Becker S, Schmidt-Chanasit J, Otto M, Vapalahti O, Zelikin AN, Bitan G, Schrader T, Münch J. The molecular tweezer CLR01 inhibits Ebola and Zika virus infection. Antiviral Res. 2018 04; 152:26-35. PMID: 29428508.
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    10. Malik R, Di J, Nair G, Attar A, Taylor K, Teng E, Klärner FG, Schrader T, Bitan G. Using Molecular Tweezers to Remodel Abnormal Protein Self-Assembly and Inhibit the Toxicity of Amyloidogenic Proteins. Methods Mol Biol. 2018; 1777:369-386. PMID: 29744849.
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    11. Hayden EY, Conovaloff JL, Mason A, Bitan G, Teplow DB. Preparation of Pure Populations of Amyloid ß-Protein Oligomers of Defined Size. Methods Mol Biol. 2018; 1779:3-12. PMID: 29886523.
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    12. Walsh RR, Krismer F, Galpern WR, Wenning GK, Low PA, Halliday G, Koroshetz WJ, Holton J, Quinn NP, Rascol O, Shaw LM, Eidelberg D, Bower P, Cummings JL, Abler V, Biedenharn J, Bitan G, Brooks DJ, Brundin P, Fernandez H, Fortier P, Freeman R, Gasser T, Hewitt A, Höglinger GU, Huentelman MJ, Jensen PH, Jeromin A, Kang UJ, Kaufmann H, Kellerman L, Khurana V, Klockgether T, Kim WS, Langer C, LeWitt P, Masliah E, Meissner W, Melki R, Ostrowitzki S, Piantadosi S, Poewe W, Robertson D, Roemer C, Schenk D, Schlossmacher M, Schmahmann JD, Seppi K, Shih L, Siderowf A, Stebbins GT, Stefanova N, Tsuji S, Sutton S, Zhang J. Recommendations of the Global Multiple System Atrophy Research Roadmap Meeting. Neurology. 2018 01 09; 90(2):74-82. PMID: 29237794.
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    13. Richter F, Subramaniam SR, Magen I, Lee P, Hayes J, Attar A, Zhu C, Franich NR, Bove N, De La Rosa K, Kwong J, Klärner FG, Schrader T, Chesselet MF, Bitan G. A Molecular Tweezer Ameliorates Motor Deficits in Mice Overexpressing a-Synuclein. Neurotherapeutics. 2017 Oct; 14(4):1107-1119. PMID: 28585223.
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    14. Xu N, Bitan G, Schrader T, Klärner FG, Osinska H, Robbins J. Inhibition of Mutant aB Crystallin-Induced Protein Aggregation by a Molecular Tweezer. J Am Heart Assoc. 2017 Aug 08; 6(8). PMID: 28862927.
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    15. Vöpel T, Bravo-Rodriguez K, Mittal S, Vachharajani S, Gnutt D, Sharma A, Steinhof A, Fatoba O, Ellrichmann G, Nshanian M, Heid C, Loo JA, Klärner FG, Schrader T, Bitan G, Wanker EE, Ebbinghaus S, Sanchez-Garcia E. Inhibition of Huntingtin Exon-1 Aggregation by the Molecular Tweezer CLR01. J Am Chem Soc. 2017 04 26; 139(16):5640-5643. PMID: 28406616.
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    16. Daloglu MU, Ray A, Gorocs Z, Xiong M, Malik R, Bitan G, McLeod E, Ozcan A. Computational On-Chip Imaging of Nanoparticles and Biomolecules using Ultraviolet Light. Sci Rep. 2017 03 09; 7:44157. PMID: 28276489.
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    17. Hayden EY, Conovaloff JL, Mason A, Bitan G, Teplow DB. Preparation of pure populations of covalently stabilized amyloid ß-protein oligomers of specific sizes. Anal Biochem. 2017 Feb 01; 518:78-85. PMID: 27810329.
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    18. Schrader T, Bitan G, Klärner FG. Molecular tweezers for lysine and arginine - powerful inhibitors of pathologic protein aggregation. Chem Commun (Camb). 2016 Oct 15; 52(76):11318-34. PMID: 27546596.
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    19. Lulla A, Barnhill L, Bitan G, Ivanova MI, Nguyen B, O'Donnell K, Stahl MC, Yamashiro C, Klärner FG, Schrader T, Sagasti A, Bronstein JM. Neurotoxicity of the Parkinson Disease-Associated Pesticide Ziram Is Synuclein-Dependent in Zebrafish Embryos. Environ Health Perspect. 2016 Nov; 124(11):1766-1775. PMID: 27301718.
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    20. Fogerson SM, van Brummen AJ, Busch DJ, Allen SR, Roychaudhuri R, Banks SM, Klärner FG, Schrader T, Bitan G, Morgan JR. Reducing synuclein accumulation improves neuronal survival after spinal cord injury. Exp Neurol. 2016 Apr; 278:105-15. PMID: 26854933.
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    21. Roychaudhuri R, Zheng X, Lomakin A, Maiti P, Condron MM, Benedek GB, Bitan G, Bowers MT, Teplow DB. Role of Species-Specific Primary Structure Differences in Aß42 Assembly and Neurotoxicity. ACS Chem Neurosci. 2015 Dec 16; 6(12):1941-55. PMID: 26421877.
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    22. Malishev R, Nandi S, Kolusheva S, Levi-Kalisman Y, Klärner FG, Schrader T, Bitan G, Jelinek R. Toxicity inhibitors protect lipid membranes from disruption by Aß42. ACS Chem Neurosci. 2015 Nov 18; 6(11):1860-9. PMID: 26317327.
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    23. Lump E, Castellano LM, Meier C, Seeliger J, Erwin N, Sperlich B, Stürzel CM, Usmani S, Hammond RM, von Einem J, Gerold G, Kreppel F, Bravo-Rodriguez K, Pietschmann T, Holmes VM, Palesch D, Zirafi O, Weissman D, Sowislok A, Wettig B, Heid C, Kirchhoff F, Weil T, Klärner FG, Schrader T, Bitan G, Sanchez-Garcia E, Winter R, Shorter J, Münch J. A molecular tweezer antagonizes seminal amyloids and HIV infection. Elife. 2015 Aug 18; 4. PMID: 26284498.
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    24. Herzog G, Shmueli MD, Levy L, Engel L, Gazit E, Klärner FG, Schrader T, Bitan G, Segal D. The Lys-Specific Molecular Tweezer, CLR01, Modulates Aggregation of the Mutant p53 DNA Binding Domain and Inhibits Its Toxicity. Biochemistry. 2015 Jun 23; 54(24):3729-38. PMID: 26030124.
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    25. Lopes DH, Attar A, Nair G, Hayden EY, Du Z, McDaniel K, Dutt S, Bravo-Rodriguez K, Mittal S, Klärner FG, Wang C, Sanchez-Garcia E, Schrader T, Bitan G. Molecular tweezers inhibit islet amyloid polypeptide assembly and toxicity by a new mechanism. ACS Chem Biol. 2015 Jun 19; 10(6):1555-69. PMID: 25844890.
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    26. Zheng X, Liu D, Klärner FG, Schrader T, Bitan G, Bowers MT. Amyloid ß-protein assembly: The effect of molecular tweezers CLR01 and CLR03. J Phys Chem B. 2015 Apr 09; 119(14):4831-41. PMID: 25751170.
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    27. Attar A, Chan WT, Klärner FG, Schrader T, Bitan G. Safety and pharmacological characterization of the molecular tweezer CLR01 - a broad-spectrum inhibitor of amyloid proteins' toxicity. BMC Pharmacol Toxicol. 2014 Apr 16; 15:23. PMID: 24735982.
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    28. Ferreira N, Pereira-Henriques A, Attar A, Klärner FG, Schrader T, Bitan G, Gales L, Saraiva MJ, Almeida MR. Molecular tweezers targeting transthyretin amyloidosis. Neurotherapeutics. 2014 Apr; 11(2):450-61. PMID: 24459092.
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    29. Acharya S, Safaie BM, Wongkongkathep P, Ivanova MI, Attar A, Klärner FG, Schrader T, Loo JA, Bitan G, Lapidus LJ. Molecular basis for preventing a-synuclein aggregation by a molecular tweezer. J Biol Chem. 2014 Apr 11; 289(15):10727-37. PMID: 24567327.
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    30. Attar A, Bitan G. Disrupting self-assembly and toxicity of amyloidogenic protein oligomers by "molecular tweezers" - from the test tube to animal models. Curr Pharm Des. 2014; 20(15):2469-83. PMID: 23859557.
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    31. Attar A, Liu T, Chan WT, Hayes J, Nejad M, Lei K, Bitan G. A shortened Barnes maze protocol reveals memory deficits at 4-months of age in the triple-transgenic mouse model of Alzheimer's disease. PLoS One. 2013; 8(11):e80355. PMID: 24236177.
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    32. Attar A, Ripoli C, Riccardi E, Maiti P, Li Puma DD, Liu T, Hayes J, Jones MR, Lichti-Kaiser K, Yang F, Gale GD, Tseng CH, Tan M, Xie CW, Straudinger JL, Klärner FG, Schrader T, Frautschy SA, Grassi C, Bitan G. Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers. Brain. 2012 Dec; 135(Pt 12):3735-48. PMID: 23183235.
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    33. Ripoli C, Piacentini R, Riccardi E, Leone L, Li Puma DD, Bitan G, Grassi C. Effects of different amyloid ß-protein analogues on synaptic function. Neurobiol Aging. 2013 Apr; 34(4):1032-44. PMID: 23046860.
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    34. Ringman JM, Fithian AT, Gylys K, Cummings JL, Coppola G, Elashoff D, Pratico D, Moskovitz J, Bitan G. Plasma methionine sulfoxide in persons with familial Alzheimer's disease mutations. Dement Geriatr Cogn Disord. 2012; 33(4):219-25. PMID: 22584618.
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    35. Solomonov I, Korkotian E, Born B, Feldman Y, Bitler A, Rahimi F, Li H, Bitan G, Sagi I. Zn2+-Aß40 complexes form metastable quasi-spherical oligomers that are cytotoxic to cultured hippocampal neurons. J Biol Chem. 2012 Jun 08; 287(24):20555-64. PMID: 22528492.
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    36. Prabhudesai S, Sinha S, Attar A, Kotagiri A, Fitzmaurice AG, Lakshmanan R, Lakshmanan R, Ivanova MI, Loo JA, Klärner FG, Schrader T, Stahl M, Bitan G, Bronstein JM. A novel "molecular tweezer" inhibitor of a-synuclein neurotoxicity in vitro and in vivo. Neurotherapeutics. 2012 Apr; 9(2):464-76. PMID: 22373667.
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    37. Sinha S, Lopes DH, Bitan G. A key role for lysine residues in amyloid ß-protein folding, assembly, and toxicity. ACS Chem Neurosci. 2012 Jun 20; 3(6):473-81. PMID: 22860216.
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    38. Sinha S, Du Z, Maiti P, Klärner FG, Schrader T, Wang C, Bitan G. Comparison of three amyloid assembly inhibitors: the sugar scyllo-inositol, the polyphenol epigallocatechin gallate, and the molecular tweezer CLR01. ACS Chem Neurosci. 2012 Jun 20; 3(6):451-8. PMID: 22860214.
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    39. Liu T, Bitan G. Modulating self-assembly of amyloidogenic proteins as a therapeutic approach for neurodegenerative diseases: strategies and mechanisms. ChemMedChem. 2012 Mar 05; 7(3):359-74. PMID: 22323134.
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    40. Lopes DH, Sinha S, Rosensweig C, Bitan G. Application of photochemical cross-linking to the study of oligomerization of amyloidogenic proteins. Methods Mol Biol. 2012; 849:11-21. PMID: 22528080.
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    41. Rosensweig C, Ono K, Murakami K, Lowenstein DK, Bitan G, Teplow DB. Preparation of stable amyloid ß-protein oligomers of defined assembly order. Methods Mol Biol. 2012; 849:23-31. PMID: 22528081.
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    42. Li H, Du Z, Lopes DH, Fradinger EA, Wang C, Bitan G. C-terminal tetrapeptides inhibit Aß42-induced neurotoxicity primarily through specific interaction at the N-terminus of Aß42. J Med Chem. 2011 Dec 22; 54(24):8451-60. PMID: 22087474.
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    43. Moskovitz J, Maiti P, Lopes DH, Oien DB, Attar A, Liu T, Mittal S, Hayes J, Bitan G. Induction of methionine-sulfoxide reductases protects neurons from amyloid ß-protein insults in vitro and in vivo. Biochemistry. 2011 Dec 13; 50(49):10687-97. PMID: 22059533.
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    44. Sinha S, Lopes DH, Du Z, Pang ES, Shanmugam A, Lomakin A, Talbiersky P, Tennstaedt A, McDaniel K, Bakshi R, Kuo PY, Ehrmann M, Benedek GB, Loo JA, Klärner FG, Schrader T, Wang C, Bitan G. Lysine-specific molecular tweezers are broad-spectrum inhibitors of assembly and toxicity of amyloid proteins. J Am Chem Soc. 2011 Oct 26; 133(42):16958-69. PMID: 21916458.
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    45. Hochdörffer K, März-Berberich J, Nagel-Steger L, Epple M, Meyer-Zaika W, Horn AH, Sticht H, Sinha S, Bitan G, Schrader T. Rational design of ß-sheet ligands against Aß42-induced toxicity. J Am Chem Soc. 2011 Mar 30; 133(12):4348-58. PMID: 21381732.
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    46. Maiti P, Piacentini R, Ripoli C, Grassi C, Bitan G. Surprising toxicity and assembly behaviour of amyloid ß-protein oxidized to sulfone. Biochem J. 2011 Jan 15; 433(2):323-32. PMID: 21044048.
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    47. Li H, Monien BH, Lomakin A, Zemel R, Fradinger EA, Tan M, Spring SM, Urbanc B, Xie CW, Benedek GB, Bitan G. Mechanistic investigation of the inhibition of Abeta42 assembly and neurotoxicity by Abeta42 C-terminal fragments. Biochemistry. 2010 Aug 03; 49(30):6358-64. PMID: 20568734.
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    48. Rahimi F, Bitan G. Selection of aptamers for amyloid beta-protein, the causative agent of Alzheimer's disease. J Vis Exp. 2010 May 13; (39). PMID: 20616783.
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    49. Maiti P, Lomakin A, Benedek GB, Bitan G. Despite its role in assembly, methionine 35 is not necessary for amyloid beta-protein toxicity. J Neurochem. 2010 Jun; 113(5):1252-62. PMID: 20345758.
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    50. Li H, Monien BH, Fradinger EA, Urbanc B, Bitan G. Biophysical characterization of Abeta42 C-terminal fragments: inhibitors of Abeta42 neurotoxicity. Biochemistry. 2010 Feb 16; 49(6):1259-67. PMID: 20050679.
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    51. Rahimi F, Murakami K, Summers JL, Chen CH, Bitan G. RNA aptamers generated against oligomeric Abeta40 recognize common amyloid aptatopes with low specificity but high sensitivity. PLoS One. 2009 Nov 10; 4(11):e7694. PMID: 19901993.
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    52. Bernstein SL, Dupuis NF, Lazo ND, Wyttenbach T, Condron MM, Bitan G, Teplow DB, Shea JE, Ruotolo BT, Robinson CV, Bowers MT. Amyloid-ß protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease. Nat Chem. 2009 Jul; 1(4):326-31. PMID: 20703363.
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    53. Maji SK, Ogorzalek Loo RR, Inayathullah M, Spring SM, Vollers SS, Condron MM, Bitan G, Loo JA, Teplow DB. Amino acid position-specific contributions to amyloid beta-protein oligomerization. J Biol Chem. 2009 Aug 28; 284(35):23580-91. PMID: 19567875.
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    54. Rahimi F, Maiti P, Bitan G. Photo-induced cross-linking of unmodified proteins (PICUP) applied to amyloidogenic peptides. J Vis Exp. 2009 Jan 12; (23). PMID: 19229175.
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    55. Fradinger EA, Monien BH, Urbanc B, Lomakin A, Tan M, Li H, Spring SM, Condron MM, Cruz L, Xie CW, Benedek GB, Bitan G. C-terminal peptides coassemble into Abeta42 oligomers and protect neurons against Abeta42-induced neurotoxicity. Proc Natl Acad Sci U S A. 2008 Sep 16; 105(37):14175-80. PMID: 18779585.
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    56. Teplow DB, Lazo ND, Bitan G, Bernstein S, Wyttenbach T, Bowers MT, Baumketner A, Shea JE, Urbanc B, Cruz L, Borreguero J, Stanley HE. Elucidating amyloid beta-protein folding and assembly: A multidisciplinary approach. Acc Chem Res. 2006 Sep; 39(9):635-45. PMID: 16981680.
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    57. Seabrook TJ, Thomas K, Jiang L, Bloom J, Spooner E, Maier M, Bitan G, Lemere CA. Dendrimeric Abeta1-15 is an effective immunogen in wildtype and APP-tg mice. Neurobiol Aging. 2007 Jun; 28(6):813-23. PMID: 16725229.
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    58. Baumketner A, Bernstein SL, Wyttenbach T, Bitan G, Teplow DB, Bowers MT, Shea JE. Amyloid beta-protein monomer structure: a computational and experimental study. Protein Sci. 2006 Mar; 15(3):420-8. PMID: 16501222.
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    59. Bitan G. Structural study of metastable amyloidogenic protein oligomers by photo-induced cross-linking of unmodified proteins. Methods Enzymol. 2006; 413:217-36. PMID: 17046399.
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    60. Fradinger EA, Bitan G. En route to early diagnosis of Alzheimer's disease--are we there yet? Trends Biotechnol. 2005 Nov; 23(11):531-3. PMID: 16165236.
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    61. Bitan G, Fradinger EA, Spring SM, Teplow DB. Neurotoxic protein oligomers--what you see is not always what you get. Amyloid. 2005 Jun; 12(2):88-95. PMID: 16011984.
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    62. Bernstein SL, Wyttenbach T, Baumketner A, Shea JE, Bitan G, Teplow DB, Bowers MT. Amyloid beta-protein: monomer structure and early aggregation states of Abeta42 and its Pro19 alloform. J Am Chem Soc. 2005 Feb 23; 127(7):2075-84. PMID: 15713083.
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    63. Bitan G, Teplow DB. Preparation of aggregate-free, low molecular weight amyloid-beta for assembly and toxicity assays. Methods Mol Biol. 2005; 299:3-9. PMID: 15980591.
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    64. Vollers SS, Teplow DB, Bitan G. Determination of Peptide oligomerization state using rapid photochemical crosslinking. Methods Mol Biol. 2005; 299:11-8. PMID: 15980592.
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    65. Bitan G, Teplow DB. Rapid photochemical cross-linking--a new tool for studies of metastable, amyloidogenic protein assemblies. Acc Chem Res. 2004 Jun; 37(6):357-64. PMID: 15196045.
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    66. Bitan G, Tarus B, Vollers SS, Lashuel HA, Condron MM, Straub JE, Teplow DB. A molecular switch in amyloid assembly: Met35 and amyloid beta-protein oligomerization. J Am Chem Soc. 2003 Dec 17; 125(50):15359-65. PMID: 14664580.
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    67. Bitan G, Vollers SS, Teplow DB. Elucidation of primary structure elements controlling early amyloid beta-protein oligomerization. J Biol Chem. 2003 Sep 12; 278(37):34882-9. PMID: 12840029.
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    68. Bitan G, Kirkitadze MD, Lomakin A, Vollers SS, Benedek GB, Teplow DB. Amyloid beta -protein (Abeta) assembly: Abeta 40 and Abeta 42 oligomerize through distinct pathways. Proc Natl Acad Sci U S A. 2003 Jan 07; 100(1):330-5. PMID: 12506200.
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    69. Sun B, Fan W, Balciunas A, Cooper JK, Bitan G, Steavenson S, Denis PE, Young Y, Adler B, Daugherty L, Manoukian R, Elliott G, Shen W, Talvenheimo J, Teplow DB, Haniu M, Haldankar R, Wypych J, Ross CA, Citron M, Richards WG. Polyglutamine repeat length-dependent proteolysis of huntingtin. Neurobiol Dis. 2002 Oct; 11(1):111-22. PMID: 12460551.
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    70. Kirkitadze MD, Bitan G, Teplow DB. Paradigm shifts in Alzheimer's disease and other neurodegenerative disorders: the emerging role of oligomeric assemblies. J Neurosci Res. 2002 Sep 01; 69(5):567-77. PMID: 12210822.
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