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Polgreen, Lynda Elizabeth

Title(s)Assistant Professor-in-Residence, Pediatrics
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    Collapse Research 
    Collapse Research Activities and Funding
    Natural History of Bone Disease and the Impact of Growth Hormone Treatment in MPS
    NIH/NIAMS K23AR057789Sep 1, 2010 - Aug 31, 2014
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Sarafoglou K, Petryk A, Mishra PE, Polgreen LE, Panoskaltsis-Mortari A, Brown R, Marino BS, Gremmels D, Shepard C, Kelly AS, Miller BS, Rudser K, McCracken C, Kochilas LK. Early characteristics of bone deficits in children with Fontan palliation. Cardiol Young. 2020 Feb 20; 1-8. PMID: 32077405.
      View in: PubMed
    2. Chen AH, Harmatz P, Nestrasil I, Eisengart JB, King KE, Rudser K, Kaizer AM, Svatkova A, Wakumoto A, Le SQ, Madden J, Young S, Zhang H, Polgreen LE, Dickson PI. Intrathecal enzyme replacement for cognitive decline in mucopolysaccharidosis type I, a randomized, open-label, controlled pilot study. Mol Genet Metab. 2020 02; 129(2):80-90. PMID: 31839529.
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    3. Lund TC, Miller WP, Liao AY, Tolar J, Shanley R, Pasquali M, Sando N, Bigger BW, Polgreen LE, Orchard PJ. Post-transplant laronidase augmentation for children with Hurler syndrome: biochemical outcomes. Sci Rep. 2019 Oct 01; 9(1):14105. PMID: 31575939.
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    4. Vera MU, Le SQ, Victoroff A, Passage MB, Brown JR, Crawford BE, Polgreen LE, Chen AH, Dickson PI. Evaluation of non-reducing end pathologic glycosaminoglycan detection method for monitoring therapeutic response to enzyme replacement therapy in human mucopolysaccharidosis I. Mol Genet Metab. 2020 02; 129(2):91-97. PMID: 31630958.
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    5. Polgreen LE, Lund TC, Braunlin E, Tolar J, Miller BS, Fung E, Whitley CB, Eisengart JB, Northrop E, Rudser K, Miller WP, Orchard PJ. Clinical trial of laronidase in Hurler syndrome after hematopoietic cell transplantation. Pediatr Res. 2020 Jan; 87(1):104-111. PMID: 31434105.
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    6. Eisengart JB, Pierpont EI, Kaizer AM, Rudser KD, King KE, Pasquali M, Polgreen LE, Dickson PI, Le SQ, Miller WP, Tolar J, Orchard PJ, Lund TC. Intrathecal enzyme replacement for Hurler syndrome: biomarker association with neurocognitive outcomes. Genet Med. 2019 11; 21(11):2552-2560. PMID: 31019279.
      View in: PubMed
    7. Martins AM, Lindstrom K, Kyosen SO, Munoz-Rojas MV, Thibault N, Polgreen LE. Short stature as a presenting symptom of attenuated Mucopolysaccharidosis type I: case report and clinical insights. BMC Endocr Disord. 2018 Nov 12; 18(1):83. PMID: 30419879.
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    8. Wu CC, Econs MJ, DiMeglio LA, Insogna KL, Levine MA, Orchard PJ, Miller WP, Petryk A, Rush ET, Shoback DM, Ward LM, Polgreen LE. Diagnosis and Management of Osteopetrosis: Consensus Guidelines From the Osteopetrosis Working Group. J Clin Endocrinol Metab. 2017 09 01; 102(9):3111-3123. PMID: 28655174.
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    9. Petryk A, Polgreen LE, Grames M, Lowe DA, Hodges JS, Karachunski P. Feasibility and tolerability of whole-body, low-intensity vibration and its effects on muscle function and bone in patients with dystrophinopathies: a pilot study. Muscle Nerve. 2017 06; 55(6):875-883. PMID: 27718512.
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    10. Polgreen LE, Kunin-Batson A, Rudser K, Vehe RK, Utz JJ, Whitley CB, Dickson P. Pilot study of the safety and effect of adalimumab on pain, physical function, and musculoskeletal disease in mucopolysaccharidosis types I and II. Mol Genet Metab Rep. 2017 Mar; 10:75-80. PMID: 28119823.
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    11. Raymond GV, Pasquali M, Polgreen LE, Dickson PI, Miller WP, Orchard PJ, Lund TC. Elevated cerebral spinal fluid biomarkers in children with mucopolysaccharidosis I-H. Sci Rep. 2016 12 02; 6:38305. PMID: 27910891.
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    12. Fujiyoshi A, Polgreen LE, Gross MD, Reis JP, Sidney S, Jacobs DR. Smoking habits and parathyroid hormone concentrations in young adults: The CARDIA study. Bone Rep. 2016 Dec; 5:104-109. PMID: 27795978.
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    13. Polgreen LE, Vehe RK, Rudser K, Kunin-Batson A, Utz JJ, Dickson P, Shapiro E, Whitley CB. Elevated TNF-a is associated with pain and physical disability in mucopolysaccharidosis types I, II, and VI. Mol Genet Metab. 2016 Apr; 117(4):427-30. PMID: 26873528.
      View in: PubMed
    14. Forlenza GP, Calhoun A, Beckman KB, Halvorsen T, Hamdoun E, Zierhut H, Sarafoglou K, Polgreen LE, Miller BS, Nathan B, Petryk A. Next generation sequencing in endocrine practice. Mol Genet Metab. 2015 Jun-Jul; 115(2-3):61-71. PMID: 25958132.
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    15. Petryk A, Polgreen LE, Barnum JL, Zhang L, Hodges JS, Baker KS, Wagner JE, Steinberger J, MacMillan ML. Bone mineral density in children with fanconi anemia after hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2015 May; 21(5):894-9. PMID: 25591848.
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    16. Gossai N, Hilgers MV, Polgreen LE, Greengard EG. Critical hypercalcemia following discontinuation of denosumab therapy for metastatic giant cell tumor of bone. Pediatr Blood Cancer. 2015 Jun; 62(6):1078-80. PMID: 25556556.
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    17. Chahla SE, Frohnert BI, Thomas W, Kelly AS, Nathan BM, Polgreen LE. Higher daily physical activity is associated with higher osteocalcin levels in adolescents. Prev Med Rep. 2015; 2:568-571. PMID: 26236583.
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    18. Cusick SE, Opoka RO, Lund TC, John CC, Polgreen LE. Vitamin D insufficiency is common in Ugandan children and is associated with severe malaria. PLoS One. 2014; 9(12):e113185. PMID: 25470777.
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    19. Oberdorfer E, Polly D, Larson-Ode K, Smith-Wright D, Guidera K, Neglia JP, Polgreen LE. Successful Spinal Fixation Surgery Following Teriparatide Treatment in an Adolescent Boy with Severe Osteoporosis and Progressive Kyphoscoliosis: A Case Report. JBJS Case Connect. 2014 Oct/Dec/Nov; 4(4):e89. PMID: 29252757.
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    20. McCauley LA, Thomas W, Laguna TA, Regelmann WE, Moran A, Polgreen LE. Vitamin D deficiency is associated with pulmonary exacerbations in children with cystic fibrosis. Ann Am Thorac Soc. 2014 Feb; 11(2):198-204. PMID: 24083951.
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    21. Stevenson DA, Rudser K, Kunin-Batson A, Fung EB, Viskochil D, Shapiro E, Orchard PJ, Whitley CB, Polgreen LE. Biomarkers of bone remodeling in children with mucopolysaccharidosis types I, II, and VI. J Pediatr Rehabil Med. 2014; 7(2):159-65. PMID: 25096868.
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    22. Taylor NE, Dengel DR, Lund TC, Rudser KD, Orchard PJ, Steinberger J, Whitley CB, Polgreen LE. Isokinetic muscle strength differences in patients with mucopolysaccharidosis I, II, and VI. J Pediatr Rehabil Med. 2014; 7(4):353-60. PMID: 25547887.
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    23. Forlenza GP, Polgreen LE, Miller BS, MacMillan ML, Wagner JE, Petryk A. Growth hormone treatment of patients with Fanconi anemia after hematopoietic cell transplantation. Pediatr Blood Cancer. 2014 Jun; 61(6):1142-3. PMID: 24376097.
      View in: PubMed
    24. Polgreen LE, Thomas W, Orchard PJ, Whitley CB, Miller BS. Effect of recombinant human growth hormone on changes in height, bone mineral density, and body composition over 1-2 years in children with Hurler or Hunter syndrome. Mol Genet Metab. 2014 Feb; 111(2):101-6. PMID: 24368158.
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    25. Wang RY, Braunlin EA, Rudser KD, Dengel DR, Metzig AM, Covault KK, Polgreen LE, Shapiro E, Steinberger J, Kelly AS. Carotid intima-media thickness is increased in patients with treated mucopolysaccharidosis types I and II, and correlates with arterial stiffness. Mol Genet Metab. 2014 Feb; 111(2):128-32. PMID: 24268528.
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    26. Petryk A, Polgreen LE, Zhang L, Hodges JS, Dengel DR, Hoffmeister PA, Steinberger J, Baker KS. Bone mineral deficits in recipients of hematopoietic cell transplantation: the impact of young age at transplant. Bone Marrow Transplant. 2014 Feb; 49(2):258-63. PMID: 24121211.
      View in: PubMed
    27. Thawrani DP, Walker K, Polgreen LE, Tolar J, Orchard PJ. Hip dysplasia in patients with Hurler syndrome (mucopolysaccharidosis type 1H). J Pediatr Orthop. 2013 Sep; 33(6):635-43. PMID: 23812141.
      View in: PubMed
    28. Fujiyoshi A, Polgreen LE, Hurley DL, Gross MD, Sidney S, Jacobs DR. A cross-sectional association between bone mineral density and parathyroid hormone and other biomarkers in community-dwelling young adults: the CARDIA study. J Clin Endocrinol Metab. 2013 Oct; 98(10):4038-46. PMID: 23966240.
      View in: PubMed
    29. Gustafson KL, Eckerle JK, Howard CR, Andrews B, Polgreen LE. Prevalence of vitamin D deficiency in international adoptees within the first 6 months after adoption. Clin Pediatr (Phila). 2013 Dec; 52(12):1149-53. PMID: 23872345.
      View in: PubMed
    30. Polgreen LE, Thomas W, Fung E, Viskochil D, Stevenson DA, Steinberger J, Orchard P, Whitley CB, Ensrud KE. Low bone mineral content and challenges in interpretation of dual-energy X-ray absorptiometry in children with mucopolysaccharidosis types I, II, and VI. J Clin Densitom. 2014 Jan-Mar; 17(1):200-6. PMID: 23562131.
      View in: PubMed
    31. Karras NA, Polgreen LE, Ogilvie C, Manivel JC, Skubitz KM, Lipsitz E. Denosumab treatment of metastatic giant-cell tumor of bone in a 10-year-old girl. J Clin Oncol. 2013 Apr 20; 31(12):e200-2. PMID: 23509309.
      View in: PubMed
    32. Polgreen LE, Rudser K, Deyo M, Smith A, Baker KS, Petryk A. Changes in biomarkers of bone resorption over the first six months after pediatric hematopoietic cell transplantation. Pediatr Transplant. 2012 Dec; 16(8):852-7. PMID: 22905997.
      View in: PubMed
    33. Polgreen LE, Jacobs DR, Nathan BM, Steinberger J, Moran A, Sinaiko AR. Association of osteocalcin with obesity, insulin resistance, and cardiovascular risk factors in young adults. Obesity (Silver Spring). 2012 Nov; 20(11):2194-201. PMID: 22573135.
      View in: PubMed
    34. Polgreen LE, Petryk A, Dietz AC, Sinaiko AR, Leisenring W, Goodman P, Steffen LM, Perkins JL, Dengel DR, Baker KS, Steinberger J. Modifiable risk factors associated with bone deficits in childhood cancer survivors. BMC Pediatr. 2012 Mar 28; 12:40. PMID: 22455440.
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    35. Petryk A, Polgreen LE, Chahla S, Miller W, Orchard PJ. No evidence for the reversal of adrenal failure after hematopoietic cell transplantation in X-linked adrenoleukodystrophy. Bone Marrow Transplant. 2012 Oct; 47(10):1377-8. PMID: 22388279.
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    36. Polgreen LE, Chahla S, Miller W, Rothman S, Tolar J, Kivisto T, Nascene D, Orchard PJ, Petryk A. Early diagnosis of cerebral X-linked adrenoleukodystrophy in boys with Addison's disease improves survival and neurological outcomes. Eur J Pediatr. 2011 Aug; 170(8):1049-54. PMID: 21279382.
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    37. McClune BL, Polgreen LE, Burmeister LA, Blaes AH, Mulrooney DA, Burns LJ, Majhail NS. Screening, prevention and management of osteoporosis and bone loss in adult and pediatric hematopoietic cell transplant recipients. Bone Marrow Transplant. 2011 Jan; 46(1):1-9. PMID: 20729922.
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    38. Polgreen LE. Keeping a broad approach to managing pediatric bone disease. J Pediatr Gastroenterol Nutr. 2010 Aug; 51(2):128-9. PMID: 20512055.
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    39. Polgreen LE, Miller BS. Growth patterns and the use of growth hormone in the mucopolysaccharidoses. J Pediatr Rehabil Med. 2010; 3(1):25-38. PMID: 20563263.
      View in: PubMed
    40. Martinez C, Polgreen LE, DeFor TE, Kivisto T, Petryk A, Tolar J, Orchard PJ. Characterization and management of hypercalcemia following transplantation for osteopetrosis. Bone Marrow Transplant. 2010 May; 45(5):939-44. PMID: 19802031.
      View in: PubMed
    41. Polgreen LE, Thomas W, MacMillan ML, Wagner JE, Moran A, Petryk A. First phase insulin release and glucose tolerance in children with Fanconi anemia after hematopoietic cell transplantation. Pediatr Blood Cancer. 2009 Aug; 53(2):191-6. PMID: 19353625.
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    42. Polgreen LE, Plog M, Schwender JD, Tolar J, Thomas W, Orchard PJ, Miller BS, Petryk A. Short-term growth hormone treatment in children with Hurler syndrome after hematopoietic cell transplantation. Bone Marrow Transplant. 2009 Sep; 44(5):279-85. PMID: 19252529.
      View in: PubMed
    43. Polgreen LE, Tolar J, Plog M, Himes JH, Orchard PJ, Whitley CB, Miller BS, Petryk A. Growth and endocrine function in patients with Hurler syndrome after hematopoietic stem cell transplantation. Bone Marrow Transplant. 2008 Jun; 41(12):1005-11. PMID: 18278070.
      View in: PubMed
    44. Polgreen L, Steiner M, Dietz CA, Manivel JC, Petryk A. Thymic hyperplasia in a child treated with growth hormone. Growth Horm IGF Res. 2007 Feb; 17(1):41-6. PMID: 17141546.
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