Ram Raj Singh

Title(s)Professor, Medicine
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    Title(s)Professor, Pathology and Laboratory Medicine

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    Role of Innate B1 B Cells in the Development of Diffuse Lung Hemorrhage
    NIH R21ES026536Aug 1, 2016 - Jul 31, 2019
    Role: Principal Investigator
    Decidual T Cells in Immune-mediated Pregnancy Loss
    NIH R21HD082812Jul 15, 2015 - Jun 30, 2018
    Role: Principal Investigator
    Pathogenesis of Lupus Dermatitis
    NIH R01AI080778Jul 6, 2009 - Jun 30, 2015
    Role: Principal Investigator
    Gender Bias in Lupus: Contribution of Sex Chromosomes
    NIH R01AR056465Sep 1, 2008 - Aug 31, 2014
    Role: Principal Investigator
    Academic Training in Rheumatology
    NIH T32AR053463Jun 1, 2007 - May 31, 2013
    Role: Principal Investigator
    Augementing Peptide-specific Tolerance in ImmuneNephrit*
    NIH R21DK069282Aug 1, 2004 - Jul 31, 2006
    Role: Principal Investigator
    Kidney Damage in Murine Lupus
    NIH R01AR050797Sep 30, 2003 - May 31, 2008
    Role: Principal Investigator
    Peptide Gene Vaccination in Lupus
    NIH R01AR047322Aug 15, 2001 - May 31, 2007
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Steady decrease in systemic sclerosis mortality rates at younger ages over the past five decades. Rheumatology (Oxford). 2024 Feb 01; 63(2):466-471. Yen EY, Singh DR, Singh RR. PMID: 37216898; PMCID: PMC10836968.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Worsening premature death burden gap from systemic sclerosis in men and black persons: A US nationwide population-based study. J Scleroderma Relat Disord. 2023 Feb; 8(1):20-26. Singh RR, Singh DR, Yen EY. PMID: 36743809; PMCID: PMC9896199.
      View in: PubMed   Mentions: 1  
    3. Diverse Roles of NETosis in the Pathogenesis of Lupus. Front Immunol. 2022; 13:895216. Wang M, Ishikawa T, Lai Y, Nallapothula D, Singh RR. PMID: 35686129; PMCID: PMC9170953.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    4. Trends in Systemic Sclerosis Mortality Over Forty-Eight Years, 1968-2015: A US Population-Based Study. Arthritis Care Res (Hoboken). 2021 10; 73(10):1502-1510. Yen EY, Singh DR, Singh RR. PMID: 32770721; PMCID: PMC7868470.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    5. Anti-vinculin antibodies in scleroderma (SSc): a potential link between autoimmunity and gastrointestinal system involvement in two SSc cohorts. Clin Rheumatol. 2021 Jun; 40(6):2277-2284. Suliman Y, Kafaja S, Oh SJ, Alemam M, Bagnato G, Abignano G, Singh RR, Barlow G, Liu X, Valera I, Morales W, Rezaie A, Pimentel M, Del Galdo F, Furst DE. PMID: 33231773.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    6. Heparin and aspirin combination therapy restores T-cell phenotype in pregnant patients with antiphospholipid syndrome-related recurrent pregnancy loss. Clin Immunol. 2019 11; 208:108259. Wang M, Zhang P, Yu S, Zhou G, Lv J, Nallapothula D, Guo C, Wang Q, Singh RR. PMID: 31513884.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCellsCTClinical Trials
    7. Generalized Cytokine Increase in the Setting of a Multisystem Clinical Disorder and Carcinoid Syndrome Associated with a Novel NLRP12 Variant. Dig Dis Sci. 2019 08; 64(8):2140-2146. Jacob N, Dasharathy SS, Bui V, Benhammou JN, Grody WW, Singh RR, Pisegna JR. PMID: 30788684; PMCID: PMC6707534.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    8. Self-glycerophospholipids activate murine phospholipid-reactive T cells and inhibit iNKT cell activation by competing with ligands for CD1d loading. Eur J Immunol. 2019 02; 49(2):242-254. Halder RC, Tran C, Prasad P, Wang J, Nallapothula D, Ishikawa T, Wang M, Zajonc DM, Singh RR. PMID: 30508304; PMCID: PMC6405219.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    9. pDCs in lung and skin fibrosis in a bleomycin-induced model and patients with systemic sclerosis. JCI Insight. 2018 05 03; 3(9). Kafaja S, Valera I, Divekar AA, Saggar R, Abtin F, Furst DE, Khanna D, Singh RR. PMID: 29720568; PMCID: PMC6012518.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    10. Effects of Invariant NKT Cells on Parasite Infections and Hygiene Hypothesis. J Immunol Res. 2016; 2016:2395645. Yang JQ, Zhou Y, Singh RR. PMID: 27563682; PMCID: PMC4987483.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    11. Langerhans Cells Maintain Local Tissue Tolerance in a Model of Systemic Autoimmune Disease. J Immunol. 2015 Jul 15; 195(2):464-76. King JK, Philips RL, Eriksson AU, Kim PJ, Halder RC, Lee DJ, Singh RR. PMID: 26071559; PMCID: PMC4562401.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    12. Germline deletion of β2 microglobulin or CD1d reduces anti-phospholipid antibody, but increases autoantibodies against non-phospholipid antigens in the NZB/W F1 model of lupus. Arthritis Res Ther. 2013 Mar 27; 15(2):R47. Singh RR, Yang JQ, Kim PJ, Halder RC. PMID: 23531237; PMCID: PMC3672782.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    13. A one-year, phase I/IIa, open-label pilot trial of imatinib mesylate in the treatment of systemic sclerosis-associated active interstitial lung disease. Arthritis Rheum. 2011 Nov; 63(11):3540-6. Khanna D, Saggar R, Mayes MD, Abtin F, Clements PJ, Maranian P, Assassi S, Saggar R, Singh RR, Furst DE. PMID: 21769849; PMCID: PMC3205223.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCTClinical Trials
    14. Homeostatic regulation of marginal zone B cells by invariant natural killer T cells. PLoS One. 2011; 6(10):e26536. Wen X, Yang JQ, Kim PJ, Singh RR. PMID: 22046304; PMCID: PMC3202546.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    15. Brief treatment with iNKT cell ligand α-galactosylceramide confers a long-term protection against lupus. J Clin Immunol. 2012 Feb; 32(1):106-13. Yang JQ, Kim PJ, Singh RR. PMID: 22002593; PMCID: PMC3432318.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    16. Treatment with imatinib results in reduced IL-4-producing T cells, but increased CD4(+) T cells in the broncho-alveolar lavage of patients with systemic sclerosis. Clin Immunol. 2011 Dec; 141(3):293-303. Divekar AA, Khanna D, Abtin F, Maranian P, Saggar R, Saggar R, Furst DE, Singh RR. PMID: 22015344; PMCID: PMC3221795.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    17. Invariant NKT cells inhibit autoreactive B cells in a contact- and CD1d-dependent manner. J Immunol. 2011 Feb 01; 186(3):1512-20. Yang JQ, Wen X, Kim PJ, Singh RR. PMID: 21209282; PMCID: PMC3039137.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    18. Dicer insufficiency and microRNA-155 overexpression in lupus regulatory T cells: an apparent paradox in the setting of an inflammatory milieu. J Immunol. 2011 Jan 15; 186(2):924-30. Divekar AA, Dubey S, Gangalum PR, Singh RR. PMID: 21149603; PMCID: PMC3038632.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    19. Galectin-1 co-clusters CD43/CD45 on dendritic cells and induces cell activation and migration through Syk and protein kinase C signaling. J Biol Chem. 2009 Sep 25; 284(39):26860-70. Fulcher JA, Chang MH, Wang S, Almazan T, Hashimi ST, Eriksson AU, Wen X, Pang M, Baum LG, Singh RR, Lee B. PMID: 19635795; PMCID: PMC2785374.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    20. Cutting edge: migration of langerhans dendritic cells is impaired in autoimmune dermatitis. J Immunol. 2008 Dec 01; 181(11):7468-72. Eriksson AU, Singh RR. PMID: 19017935; PMCID: PMC2766617.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    21. Dual roles of immunoregulatory cytokine TGF-beta in the pathogenesis of autoimmunity-mediated organ damage. J Immunol. 2008 Feb 01; 180(3):1903-12. Saxena V, Lienesch DW, Zhou M, Bommireddy R, Azhar M, Doetschman T, Singh RR. PMID: 18209088; PMCID: PMC2291535.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    22. TNFalpha blockade in human diseases: an overview of efficacy and safety. Clin Immunol. 2008 Jan; 126(1):13-30. Lin J, Ziring D, Desai S, Kim S, Wong M, Korin Y, Braun J, Reed E, Gjertson D, Singh RR. PMID: 17916445; PMCID: PMC2291511.
      View in: PubMed   Mentions: 86     Fields:    Translation:Humans
    23. TNFalpha blockade in human diseases: mechanisms and future directions. Clin Immunol. 2008 Feb; 126(2):121-36. Wong M, Ziring D, Korin Y, Desai S, Kim S, Lin J, Gjertson D, Braun J, Reed E, Singh RR. PMID: 17916444; PMCID: PMC2291518.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansAnimals
    24. SLE: translating lessons from model systems to human disease. Trends Immunol. 2005 Nov; 26(11):572-9. Singh RR. PMID: 16153890; PMCID: PMC2291517.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    25. Cellular and molecular mechanisms of regulation of autoantibody production in lupus. Ann N Y Acad Sci. 2005 Jun; 1051:433-41. Hahn BH, Ebling F, Singh RR, Singh RP, Karpouzas G, La Cava A. PMID: 16126985; PMCID: PMC2291525.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    26. Differences between CD8+ T cells in lupus-prone (NZB x NZW) F1 mice and healthy (BALB/c x NZW) F1 mice may influence autoimmunity in the lupus model. Eur J Immunol. 2004 Sep; 34(9):2489-99. Karpouzas GA, La Cava A, Ebling FM, Singh RR, Hahn BH. PMID: 15307181; PMCID: PMC2291530.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCellsPHPublic Health
    27. CD1d deficiency exacerbates inflammatory dermatitis in MRL-lpr/lpr mice. Eur J Immunol. 2004 Jun; 34(6):1723-32. Yang JQ, Chun T, Liu H, Hong S, Bui H, Van Kaer L, Wang CR, Singh RR. PMID: 15162443; PMCID: PMC2291526.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    28. Prevention and control of reciprocal T-B cell diversification: implications for lupus-like autoimmunity. Mol Immunol. 2004 Feb; 40(14-15):1137-45. Singh RR. PMID: 15036920.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    29. Repeated alpha-galactosylceramide administration results in expansion of NK T cells and alleviates inflammatory dermatitis in MRL-lpr/lpr mice. J Immunol. 2003 Oct 15; 171(8):4439-46. Yang JQ, Saxena V, Xu H, Van Kaer L, Wang CR, Singh RR. PMID: 14530371.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    30. Immunoregulatory role of CD1d in the hydrocarbon oil-induced model of lupus nephritis. J Immunol. 2003 Aug 15; 171(4):2142-53. Yang JQ, Singh AK, Wilson MT, Satoh M, Stanic AK, Park JJ, Hong S, Gadola SD, Mizutani A, Kakumanu SR, Reeves WH, Cerundolo V, Joyce S, Van Kaer L, Singh RR. PMID: 12902521.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    31. Vaccination with minigenes encoding V(H)-derived major histocompatibility complex class I-binding epitopes activates cytotoxic T cells that ablate autoantibody-producing B cells and inhibit lupus. J Exp Med. 2002 Sep 16; 196(6):731-41. Fan GC, Singh RR. PMID: 12235207; PMCID: PMC2194049.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCellsPHPublic Health
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