Kenneth L Lange

Title(s)Professor, Computational Medicine
SchoolMedicine
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    Title(s)Professor, Human Genetics


    Collapse Research 
    Collapse Research Activities and Funding
    Modeling, Inference, and Optimization for Genomic and Biomedical Big Data
    NIH R35GM141798Jul 1, 2021 - May 31, 2026
    Role: Principal Investigator
    Training Grant in Genomic Analysis and Interpretation
    NIH T32HG002536Jul 1, 2002 - Jun 30, 2022
    Role: Co-Principal Investigator
    Statistical Methods for Gene Mapping
    NIH R01GM053275Aug 1, 1995 - Mar 31, 2021
    Role: Principal Investigator
    Systems in Integrative Biology
    NIH T32GM008185Jul 1, 1987 - Jun 30, 2023
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A fast Data-Driven method for genotype imputation, phasing, and local ancestry inference: MendelImpute.jl. Bioinformatics. 2021 Jul 21. Chu BB, Sobel EM, Wasiolek R, Ko S, Sinsheimer JS, Zhou H, Lange K. PMID: 34289008; PMCID: PMC8665755.
      View in: PubMed   Mentions:
    2. An examination of school reopening strategies during the SARS-CoV-2 pandemic. PLoS One. 2021; 16(5):e0251242. Landeros A, Ji X, Lange K, Stutz TC, Xu J, Sehl ME, Sinsheimer JS. PMID: 34014947; PMCID: PMC8136712.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    3. Modern simulation utilities for genetic analysis. BMC Bioinformatics. 2021 May 03; 22(1):228. Ji SS, German CA, Lange K, Sinsheimer JS, Zhou H, Zhou J, Sobel EM. PMID: 33941078; PMCID: PMC8091532.
      View in: PubMed   Mentions:
    4. An examination of school reopening strategies during the SARS-CoV-2 pandemic. medRxiv. 2021 Mar 19. Landeros A, Ji X, Lange K, Stutz TC, Xu J, Sehl ME, Sinsheimer JS. PMID: 32793918; PMCID: PMC7418733.
      View in: PubMed   Mentions:
    5. Stochastic simulation algorithms for Interacting Particle Systems. PLoS One. 2021; 16(3):e0247046. Stutz TC, Landeros A, Xu J, Sinsheimer JS, Sehl M, Lange K. PMID: 33651796; PMCID: PMC7924777.
      View in: PubMed   Mentions:    Fields:    
    6. Pooled analysis of radiation hybrids identifies loci for growth and drug action in mammalian cells. Genome Res. 2020 10; 30(10):1458-1467. Khan AH, Lin A, Wang RT, Bloom JS, Lange K, Smith DJ. PMID: 32878976; PMCID: PMC7605260.
      View in: PubMed   Mentions:    Fields:    
    7. Iterative hard thresholding in genome-wide association studies: Generalized linear models, prior weights, and double sparsity. Gigascience. 2020 06 01; 9(6). Chu BB, Keys KL, German CA, Zhou H, Zhou JJ, Sobel EM, Sinsheimer JS, Lange K. PMID: 32491161; PMCID: PMC7268817.
      View in: PubMed   Mentions:
    8. OPENMENDEL: a cooperative programming project for statistical genetics. Hum Genet. 2020 Jan; 139(1):61-71. Zhou H, Sinsheimer JS, Bates DM, Chu BB, German CA, Ji SS, Keys KL, Kim J, Ko S, Mosher GD, Papp JC, Sobel EM, Zhai J, Zhou JJ, Lange K. PMID: 30915546; PMCID: PMC6763373.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    9. MM Algorithms For Variance Components Models. J Comput Graph Stat. 2019; 28(2):350-361. Zhou H, Hu L, Zhou J, Lange K. PMID: 31592195; PMCID: PMC6779174.
      View in: PubMed   Mentions: 1  
    10. BioSimulator.jl: Stochastic simulation in Julia. Comput Methods Programs Biomed. 2018 Dec; 167:23-35. Landeros A, Stutz T, Keys KL, Alekseyenko A, Sinsheimer JS, Lange K, Sehl ME. PMID: 30501857; PMCID: PMC6388686.
      View in: PubMed   Mentions: 2     Fields:    
    11. Fast Genome-Wide QTL Association Mapping on Pedigree and Population Data. Genet Epidemiol. 2017 04; 41(3):174-186. Zhou H, Blangero J, Dyer TD, Chan KK, Lange K, Sobel EM. PMID: 27943406; PMCID: PMC5340631.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    12. Genome-wide QTL and eQTL analyses using Mendel. BMC Proc. 2016; 10(Suppl 7):239-244. Zhou H, Zhou J, Hu T, Sobel EM, Lange K. PMID: 27980643; PMCID: PMC5133530.
      View in: PubMed   Mentions:
    13. Modeling of Cancer Stem Cell State Transitions Predicts Therapeutic Response. PLoS One. 2015; 10(9):e0135797. Sehl ME, Shimada M, Landeros A, Lange K, Wicha MS. PMID: 26397099; PMCID: PMC4580445.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    14. A multivariate Bernoulli model to predict DNaseI hypersensitivity status from haplotype data. Bioinformatics. 2015 Nov 01; 31(21):3514-21. Shi H, Pasaniuc B, Lange KL. PMID: 26139633; PMCID: PMC4836401.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    15. Distance majorization and its applications. Math Program. 2014 Aug 01; 146:409-436. Chi EC, Zhou H, Lange K. PMID: 25392563; PMCID: PMC4226185.
      View in: PubMed   Mentions: 1  
    16. Fast spatial ancestry via flexible allele frequency surfaces. Bioinformatics. 2014 Oct 15; 30(20):2915-22. Rañola JM, Novembre J, Lange K. PMID: 25012181; PMCID: PMC4184261.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    17. A Brief Survey of Modern Optimization for Statisticians. Int Stat Rev. 2014 Apr 01; 82(1):46-70. Lange K, Chi EC, Zhou H. PMID: 25242858; PMCID: PMC4166522.
      View in: PubMed   Mentions: 2  
    18. Hadamard's Determinant Inequality. Am Math Mon. 2014 Mar 01; 121(3):258-259. Lange K. PMID: 25284823; PMCID: PMC4183455.
      View in: PubMed   Mentions:
    19. MM Algorithms for Geometric and Signomial Programming. Math Program. 2014 Feb 01; 143(1-2):339-356. Lange K, Zhou H. PMID: 24634545; PMCID: PMC3950732.
      View in: PubMed   Mentions: 2  
    20. A Look at the Generalized Heron Problem through the Lens of Majorization-Minimization. Am Math Mon. 2014 Feb; 121(2):95-108. Chi EC, Lange K. PMID: 25242816; PMCID: PMC4169126.
      View in: PubMed   Mentions: 1  
    21. Next Generation Statistical Genetics: Modeling, Penalization, and Optimization in High-Dimensional Data. Annu Rev Stat Appl. 2014 Jan 01; 1(1):279-300. Lange K, Papp JC, Sinsheimer JS, Sobel EM. PMID: 24955378; PMCID: PMC4062304.
      View in: PubMed   Mentions: 12  
    22. IMAGING GENETICS VIA SPARSE CANONICAL CORRELATION ANALYSIS. Proc IEEE Int Symp Biomed Imaging. 2013 Dec 31; 2013:740-743. Chi EC, Allen GI, Zhou H, Kohannim O, Lange K, Thompson PM. PMID: 24443689; PMCID: PMC3892670.
      View in: PubMed   Mentions: 16  
    23. Mendel: the Swiss army knife of genetic analysis programs. Bioinformatics. 2013 Jun 15; 29(12):1568-70. Lange K, Papp JC, Sinsheimer JS, Sripracha R, Zhou H, Sobel EM. PMID: 23610370; PMCID: PMC3673222.
      View in: PubMed   Mentions: 60     Fields:    Translation:Humans
    24. Cluster and propensity based approximation of a network. BMC Syst Biol. 2013 Mar 14; 7:21. Ranola JM, Langfelder P, Lange K, Horvath S. PMID: 23497424; PMCID: PMC3663730.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    25. Determining duration of HER2-targeted therapy using stem cell extinction models. PLoS One. 2012; 7(12):e46613. Riley L, Zhou H, Lange K, Sinsheimer JS, Sehl ME. PMID: 23284608; PMCID: PMC3532453.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    26. Genotype imputation via matrix completion. Genome Res. 2013 Mar; 23(3):509-18. Chi EC, Zhou H, Chen GK, Del Vecchyo DO, Lange K. PMID: 23233546; PMCID: PMC3589539.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    27. Reconstructing DNA copy number by joint segmentation of multiple sequences. BMC Bioinformatics. 2012 Aug 16; 13:205. Zhang Z, Lange K, Sabatti C. PMID: 22897923; PMCID: PMC3534631.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    28. Effects of genome-wide copy number variation on expression in mammalian cells. BMC Genomics. 2011 Nov 16; 12:562. Wang RT, Ahn S, Park CC, Khan AH, Lange K, Smith DJ. PMID: 22085887; PMCID: PMC3287593.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    29. Extinction models for cancer stem cell therapy. Math Biosci. 2011 Dec; 234(2):132-46. Sehl M, Zhou H, Sinsheimer JS, Lange KL. PMID: 22001354; PMCID: PMC3312607.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    30. Stability selection for genome-wide association. Genet Epidemiol. 2011 Nov; 35(7):722-8. Alexander DH, Lange K. PMID: 22009793.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    31. Unifying ideas for non-parametric linkage analysis. Hum Hered. 2011; 71(4):267-80. Day-Williams AG, Blangero J, Dyer TD, Lange K, Sobel EM. PMID: 21822022; PMCID: PMC7077094.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    32. Enhancements to the ADMIXTURE algorithm for individual ancestry estimation. BMC Bioinformatics. 2011 Jun 18; 12:246. Alexander DH, Lange K. PMID: 21682921; PMCID: PMC3146885.
      View in: PubMed   Mentions: 212     Fields:    Translation:Humans
    33. Linkage analysis without defined pedigrees. Genet Epidemiol. 2011 Jul; 35(5):360-70. Day-Williams AG, Blangero J, Dyer TD, Lange K, Sobel EM. PMID: 21465549; PMCID: PMC3290352.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    34. A quasi-Newton acceleration for high-dimensional optimization algorithms. Stat Comput. 2011 Jan 04; 21(2):261-273. Zhou H, Alexander D, Lange K. PMID: 21359052; PMCID: PMC3045213.
      View in: PubMed   Mentions: 32  
    35. A Fast Procedure for Calculating Importance Weights in Bootstrap Sampling. Comput Stat Data Anal. 2011 Jan 01; 55(1):26-33. Zhou H, Lange K. PMID: 21076658; PMCID: PMC2976546.
      View in: PubMed   Mentions: 1  
    36. RECONSTRUCTING DNA COPY NUMBER BY PENALIZED ESTIMATION AND IMPUTATION. Ann Appl Stat. 2010 Dec 01; 4(4):1749-1773. Zhang Z, Lange K, Ophoff R, Sabatti C. PMID: 21572975; PMCID: PMC3092301.
      View in: PubMed   Mentions: 7  
    37. On the Bumpy Road to the Dominant Mode. Scand Stat Theory Appl. 2010 Dec; 37(4):612-631. Zhou H, Lange KL. PMID: 21170287; PMCID: PMC3002233.
      View in: PubMed   Mentions: 5  
    38. MM Algorithms for Some Discrete Multivariate Distributions. J Comput Graph Stat. 2010 Sep 01; 19(3):645-665. Zhou H, Lange K. PMID: 20877446; PMCID: PMC2945396.
      View in: PubMed   Mentions: 12  
    39. Association screening of common and rare genetic variants by penalized regression. Bioinformatics. 2010 Oct 01; 26(19):2375-82. Zhou H, Sehl ME, Sinsheimer JS, Lange K. PMID: 20693321; PMCID: PMC3025646.
      View in: PubMed   Mentions: 63     Fields:    Translation:Humans
    40. Modeling maternal-offspring gene-gene interactions: the extended-MFG test. Genet Epidemiol. 2010 Jul; 34(5):512-21. Childs EJ, Palmer CG, Lange K, Sinsheimer JS. PMID: 20552637; PMCID: PMC3165170.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    41. A Poisson model for random multigraphs. Bioinformatics. 2010 Aug 15; 26(16):2004-11. Ranola JM, Ahn S, Sehl M, Smith DJ, Lange K. PMID: 20554690; PMCID: PMC3025746.
      View in: PubMed   Mentions: 5     Fields:    
    42. Prioritizing GWAS results: A review of statistical methods and recommendations for their application. Am J Hum Genet. 2010 Jan; 86(1):6-22. Cantor RM, Lange K, Sinsheimer JS. PMID: 20074509; PMCID: PMC2801749.
      View in: PubMed   Mentions: 264     Fields:    Translation:HumansAnimals
    43. Differential destruction of stem cells: implications for targeted cancer stem cell therapy. Cancer Res. 2009 Dec 15; 69(24):9481-9. Sehl ME, Sinsheimer JS, Zhou H, Lange KL. PMID: 19996291; PMCID: PMC2844253.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    44. Rating Movies and Rating the Raters Who Rate Them. Am Stat. 2009 Nov 01; 63(4):297-307. Zhou H, Lange K. PMID: 20802818; PMCID: PMC2929029.
      View in: PubMed   Mentions: 1  
    45. Accurate stochastic simulation via the step anticipation tau-leaping (SAL) algorithm. J Comput Biol. 2009 Sep; 16(9):1195-208. Sehl M, Alekseyenko AV, Lange KL. PMID: 19772431; PMCID: PMC3148118.
      View in: PubMed   Mentions: 7     Fields:    
    46. Fast model-based estimation of ancestry in unrelated individuals. Genome Res. 2009 Sep; 19(9):1655-64. Alexander DH, Novembre J, Lange K. PMID: 19648217; PMCID: PMC2752134.
      View in: PubMed   Mentions: 1951     Fields:    Translation:Humans
    47. Sharp Quadratic Majorization in One Dimension. Comput Stat Data Anal. 2009 May 15; 53(7):2471-2484. de Leeuw J, Lange K. PMID: 21738282; PMCID: PMC3129714.
      View in: PubMed   Mentions: 1  
    48. A heterozygote-homozygote test of Hardy-Weinberg equilibrium. Eur J Hum Genet. 2009 Nov; 17(11):1495-500. Zhou JJ, Lange K, Papp JC, Sinsheimer JS. PMID: 19367317; PMCID: PMC2986695.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    49. Penalized estimation of haplotype frequencies. Bioinformatics. 2008 Jul 15; 24(14):1596-602. Ayers KL, Lange K. PMID: 18487240.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    50. Fine mapping of regulatory loci for mammalian gene expression using radiation hybrids. Nat Genet. 2008 Apr; 40(4):421-9. Park CC, Ahn S, Bloom JS, Lin A, Wang RT, Wu T, Sekar A, Khan AH, Farr CJ, Lusis AJ, Leahy RM, Lange K, Smith DJ. PMID: 18362883; PMCID: PMC3014048.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    51. Estimating ethnic admixture from pedigree data. Am J Hum Genet. 2008 Mar; 82(3):748-55. Sinsheimer JS, Plaisier CL, Huertas-Vazquez A, Aguilar-Salinas C, Tusie-Luna T, Pajukanta P, Lange K. PMID: 18319077; PMCID: PMC2427215.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    52. Bayesian Gaussian Mixture Models for High-Density Genotyping Arrays. J Am Stat Assoc. 2008 03 01; 103(481):89-100. Sabatti C, Lange K. PMID: 21572926; PMCID: PMC3092390.
      View in: PubMed   Mentions: 3  
    53. A dictionary model for haplotyping, genotype calling, and association testing. Genet Epidemiol. 2007 Nov; 31(7):672-83. Ayers KL, Sabatti C, Lange K. PMID: 17487885.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    54. Merging microsatellite data. J Comput Biol. 2006 Jul-Aug; 13(6):1131-47. Presson AP, Sobel E, Lange K, Papp JC. PMID: 16901233.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    55. Variance component models for X-linked QTLs. Genet Epidemiol. 2006 Jul; 30(5):380-3. Lange K, Sobel E. PMID: 16671110.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    56. Accommodating chromosome inversions in linkage analysis. Am J Hum Genet. 2006 Aug; 79(2):238-51. Chen GK, Slaten E, Ophoff RA, Lange K. PMID: 16826515; PMCID: PMC1559487.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    57. Reconstructing ancestral haplotypes with a dictionary model. J Comput Biol. 2006 Apr; 13(3):767-85. Ayers KL, Sabatti C, Lange K. PMID: 16706724.
      View in: PubMed   Mentions: 1     Fields:    
    58. Association testing with Mendel. Genet Epidemiol. 2005 Jul; 29(1):36-50. Lange K, Sinsheimer JS, Sobel E. PMID: 15834862.
      View in: PubMed   Mentions: 43     Fields:    Translation:Humans
    59. Association testing in a linked region using large pedigrees. Am J Hum Genet. 2005 Mar; 76(3):538-42. Cantor RM, Chen GK, Pajukanta P, Lange K. PMID: 15657872; PMCID: PMC1196405.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    60. Vocabulon: a dictionary model approach for reconstruction and localization of transcription factor binding sites. Bioinformatics. 2005 Apr 01; 21(7):922-31. Sabatti C, Rohlin L, Lange K, Liao JC. PMID: 15509602.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    61. The pedigree trimming problem. Hum Hered. 2004; 58(2):108-11. Lange K, Sinsheimer JS. PMID: 15711090.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    62. Applications of codon and rate variation models in molecular phylogeny. Mol Biol Evol. 2002 Sep; 19(9):1550-62. Schadt EE, Sinsheimer JS, Lange K. PMID: 12200482.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    63. Codon and rate variation models in molecular phylogeny. Mol Biol Evol. 2002 Sep; 19(9):1534-49. Schadt E, Lange K. PMID: 12200481.
      View in: PubMed   Mentions: 8     Fields:    
    64. Palmar hyperhidrosis: evidence of genetic transmission. J Vasc Surg. 2002 Feb; 35(2):382-6. Ro KM, Cantor RM, Lange KL, Ahn SS. PMID: 11854739.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    65. Detection and integration of genotyping errors in statistical genetics. Am J Hum Genet. 2002 Feb; 70(2):496-508. Sobel E, Papp JC, Lange K. PMID: 11791215; PMCID: PMC384922.
      View in: PubMed   Mentions: 139     Fields:    Translation:Humans
    66. Spline methods for the comparison of physical and genetic maps. J Comput Biol. 2002; 9(3):465-75. Berloff N, Perola M, Lange K. PMID: 12162886.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
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