Kenneth L Lange

Title(s)Professor, Computational Medicine
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    Title(s)Professor, Human Genetics

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    Kenneth L. Lange, Ph.D., holds the Maxine and Eugene Rosenfeld Endowed Chair in Computational Genetics.

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    Collapse Research Activities and Funding
    Modeling, Inference, and Optimization for Genomic and Biomedical Big Data
    NIH R35GM141798Jul 1, 2021 - May 31, 2026
    Role: Principal Investigator
    Training Grant in Genomic Analysis and Interpretation
    NIH T32HG002536Jul 1, 2002 - Jun 30, 2022
    Role: Co-Principal Investigator
    Statistical Methods for Gene Mapping
    NIH R01GM053275Aug 1, 1995 - Mar 31, 2021
    Role: Principal Investigator
    Systems in Integrative Biology
    NIH T32GM008185Jul 1, 1987 - Jun 30, 2023
    Role: Co-Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. A Majorization-Minimization Algorithm for Neuroimage Registration. SIAM J Imaging Sci. 2024; 17(1):273-300. Zhou G, Tward D, Lange K. PMID: 38550750; PMCID: PMC10977051.
      View in: PubMed   Mentions:
    2. Computation of the Hausdorff Distance between Two Compact Convex Sets. Algorithms. 2023 Oct; 16(10). Lange K. PMID: 38529123; PMCID: PMC10961591.
      View in: PubMed   Mentions:
    3. MM optimization: Proximal distance algorithms, path following, and trust regions. Proc Natl Acad Sci U S A. 2023 Jul 04; 120(27):e2303168120. Landeros A, Xu J, Lange K. PMID: 37339185; PMCID: PMC10319036.
      View in: PubMed   Mentions:    Fields:    
    4. Multivariate genome-wide association analysis by iterative hard thresholding. Bioinformatics. 2023 04 03; 39(4). Chu BB, Ko S, Zhou JJ, Jensen A, Zhou H, Sinsheimer JS, Lange K. PMID: 37067496; PMCID: PMC10133532.
      View in: PubMed   Mentions:    Fields:    
    5. Unsupervised discovery of ancestry-informative markers and genetic admixture proportions in biobank-scale datasets. Am J Hum Genet. 2023 02 02; 110(2):314-325. Ko S, Chu BB, Peterson D, Okenwa C, Papp JC, Alexander DH, Sobel EM, Zhou H, Lange KL. PMID: 36610401; PMCID: PMC9943729.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Algorithms for Sparse Support Vector Machines. J Comput Graph Stat. 2023; 32(3):1097-1108. Landeros A, Lange K. PMID: 37982129; PMCID: PMC10656054.
      View in: PubMed   Mentions:
    7. A Legacy of EM Algorithms. Int Stat Rev. 2022 Dec; 90(Suppl 1):S52-S66. Lange K, Zhou H. PMID: 37204987; PMCID: PMC10191373.
      View in: PubMed   Mentions:
    8. Differential methods for assessing sensitivity in biological models. PLoS Comput Biol. 2022 06; 18(6):e1009598. Mester R, Landeros A, Rackauckas C, Lange K. PMID: 35696417; PMCID: PMC9232177.
      View in: PubMed   Mentions: 1     Fields:    
    9. Extensions to the Proximal Distance Method of Constrained Optimization. J Mach Learn Res. 2022; 23. Landeros A, Padilla OHM, Zhou H, Lange K. PMID: 37205013; PMCID: PMC10191389.
      View in: PubMed   Mentions: 4  
    10. A fast data-driven method for genotype imputation, phasing and local ancestry inference: MendelImpute.jl. Bioinformatics. 2021 12 11; 37(24):4756-4763. Chu BB, Sobel EM, Wasiolek R, Ko S, Sinsheimer JS, Zhou H, Lange K. PMID: 34289008; PMCID: PMC8665755.
      View in: PubMed   Mentions: 2     Fields:    
    11. An examination of school reopening strategies during the SARS-CoV-2 pandemic. PLoS One. 2021; 16(5):e0251242. Landeros A, Ji X, Lange K, Stutz TC, Xu J, Sehl ME, Sinsheimer JS. PMID: 34014947; PMCID: PMC8136712.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansPHPublic Health
    12. Modern simulation utilities for genetic analysis. BMC Bioinformatics. 2021 May 03; 22(1):228. Ji SS, German CA, Lange K, Sinsheimer JS, Zhou H, Zhou J, Sobel EM. PMID: 33941078; PMCID: PMC8091532.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    13. An examination of school reopening strategies during the SARS-CoV-2 pandemic. medRxiv. 2021 Mar 19. Landeros A, Ji X, Lange K, Stutz TC, Xu J, Sehl ME, Sinsheimer JS. PMID: 32793918; PMCID: PMC7418733.
      View in: PubMed   Mentions:
    14. Stochastic simulation algorithms for Interacting Particle Systems. PLoS One. 2021; 16(3):e0247046. Stutz TC, Landeros A, Xu J, Sinsheimer JS, Sehl M, Lange K. PMID: 33651796; PMCID: PMC7924777.
      View in: PubMed   Mentions:    Fields:    
    15. Pooled analysis of radiation hybrids identifies loci for growth and drug action in mammalian cells. Genome Res. 2020 10; 30(10):1458-1467. Khan AH, Lin A, Wang RT, Bloom JS, Lange K, Smith DJ. PMID: 32878976; PMCID: PMC7605260.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    16. Iterative hard thresholding in genome-wide association studies: Generalized linear models, prior weights, and double sparsity. Gigascience. 2020 06 01; 9(6). Chu BB, Keys KL, German CA, Zhou H, Zhou JJ, Sobel EM, Sinsheimer JS, Lange K. PMID: 32491161; PMCID: PMC7268817.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    17. OPENMENDEL: a cooperative programming project for statistical genetics. Hum Genet. 2020 Jan; 139(1):61-71. Zhou H, Sinsheimer JS, Bates DM, Chu BB, German CA, Ji SS, Keys KL, Kim J, Ko S, Mosher GD, Papp JC, Sobel EM, Zhai J, Zhou JJ, Lange K. PMID: 30915546; PMCID: PMC6763373.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    18. MM Algorithms For Variance Components Models. J Comput Graph Stat. 2019; 28(2):350-361. Zhou H, Hu L, Zhou J, Lange K. PMID: 31592195; PMCID: PMC6779174.
      View in: PubMed   Mentions: 8  
    19. BioSimulator.jl: Stochastic simulation in Julia. Comput Methods Programs Biomed. 2018 Dec; 167:23-35. Landeros A, Stutz T, Keys KL, Alekseyenko A, Sinsheimer JS, Lange K, Sehl ME. PMID: 30501857; PMCID: PMC6388686.
      View in: PubMed   Mentions: 5     Fields:    
    20. Fast Genome-Wide QTL Association Mapping on Pedigree and Population Data. Genet Epidemiol. 2017 04; 41(3):174-186. Zhou H, Blangero J, Dyer TD, Chan KK, Lange K, Sobel EM. PMID: 27943406; PMCID: PMC5340631.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    21. Genome-wide QTL and eQTL analyses using Mendel. BMC Proc. 2016; 10(Suppl 7):239-244. Zhou H, Zhou J, Hu T, Sobel EM, Lange K. PMID: 27980643; PMCID: PMC5133530.
      View in: PubMed   Mentions: 1  
    22. Modeling of Cancer Stem Cell State Transitions Predicts Therapeutic Response. PLoS One. 2015; 10(9):e0135797. Sehl ME, Shimada M, Landeros A, Lange K, Wicha MS. PMID: 26397099; PMCID: PMC4580445.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    23. A multivariate Bernoulli model to predict DNaseI hypersensitivity status from haplotype data. Bioinformatics. 2015 Nov 01; 31(21):3514-21. Shi H, Pasaniuc B, Lange KL. PMID: 26139633; PMCID: PMC4836401.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    24. Distance majorization and its applications. Math Program. 2014 Aug 01; 146:409-436. Chi EC, Zhou H, Lange K. PMID: 25392563; PMCID: PMC4226185.
      View in: PubMed   Mentions: 8  
    25. Fast spatial ancestry via flexible allele frequency surfaces. Bioinformatics. 2014 Oct 15; 30(20):2915-22. Rañola JM, Novembre J, Lange K. PMID: 25012181; PMCID: PMC4184261.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    26. A Brief Survey of Modern Optimization for Statisticians. Int Stat Rev. 2014 Apr 01; 82(1):46-70. Lange K, Chi EC, Zhou H. PMID: 25242858; PMCID: PMC4166522.
      View in: PubMed   Mentions: 3  
    27. Hadamard's Determinant Inequality. Am Math Mon. 2014 Mar 01; 121(3):258-259. Lange K. PMID: 25284823; PMCID: PMC4183455.
      View in: PubMed   Mentions:
    28. MM Algorithms for Geometric and Signomial Programming. Math Program. 2014 Feb 01; 143(1-2):339-356. Lange K, Zhou H. PMID: 24634545; PMCID: PMC3950732.
      View in: PubMed   Mentions: 2  
    29. A Look at the Generalized Heron Problem through the Lens of Majorization-Minimization. Am Math Mon. 2014 Feb; 121(2):95-108. Chi EC, Lange K. PMID: 25242816; PMCID: PMC4169126.
      View in: PubMed   Mentions: 1  
    30. Next Generation Statistical Genetics: Modeling, Penalization, and Optimization in High-Dimensional Data. Annu Rev Stat Appl. 2014 Jan 01; 1(1):279-300. Lange K, Papp JC, Sinsheimer JS, Sobel EM. PMID: 24955378; PMCID: PMC4062304.
      View in: PubMed   Mentions: 15  
    31. IMAGING GENETICS VIA SPARSE CANONICAL CORRELATION ANALYSIS. Proc IEEE Int Symp Biomed Imaging. 2013 Dec 31; 2013:740-743. Chi EC, Allen GI, Zhou H, Kohannim O, Lange K, Thompson PM. PMID: 24443689; PMCID: PMC3892670.
      View in: PubMed   Mentions: 20  
    32. Mendel: the Swiss army knife of genetic analysis programs. Bioinformatics. 2013 Jun 15; 29(12):1568-70. Lange K, Papp JC, Sinsheimer JS, Sripracha R, Zhou H, Sobel EM. PMID: 23610370; PMCID: PMC3673222.
      View in: PubMed   Mentions: 66     Fields:    Translation:Humans
    33. Cluster and propensity based approximation of a network. BMC Syst Biol. 2013 Mar 14; 7:21. Ranola JM, Langfelder P, Lange K, Horvath S. PMID: 23497424; PMCID: PMC3663730.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    34. Determining duration of HER2-targeted therapy using stem cell extinction models. PLoS One. 2012; 7(12):e46613. Riley L, Zhou H, Lange K, Sinsheimer JS, Sehl ME. PMID: 23284608; PMCID: PMC3532453.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    35. Genotype imputation via matrix completion. Genome Res. 2013 Mar; 23(3):509-18. Chi EC, Zhou H, Chen GK, Del Vecchyo DO, Lange K. PMID: 23233546; PMCID: PMC3589539.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    36. Reconstructing DNA copy number by joint segmentation of multiple sequences. BMC Bioinformatics. 2012 Aug 16; 13:205. Zhang Z, Lange K, Sabatti C. PMID: 22897923; PMCID: PMC3534631.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    37. Effects of genome-wide copy number variation on expression in mammalian cells. BMC Genomics. 2011 Nov 16; 12:562. Wang RT, Ahn S, Park CC, Khan AH, Lange K, Smith DJ. PMID: 22085887; PMCID: PMC3287593.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    38. Extinction models for cancer stem cell therapy. Math Biosci. 2011 Dec; 234(2):132-46. Sehl M, Zhou H, Sinsheimer JS, Lange KL. PMID: 22001354; PMCID: PMC3312607.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    39. Stability selection for genome-wide association. Genet Epidemiol. 2011 Nov; 35(7):722-8. Alexander DH, Lange K. PMID: 22009793.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    40. Unifying ideas for non-parametric linkage analysis. Hum Hered. 2011; 71(4):267-80. Day-Williams AG, Blangero J, Dyer TD, Lange K, Sobel EM. PMID: 21822022; PMCID: PMC7077094.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    41. Enhancements to the ADMIXTURE algorithm for individual ancestry estimation. BMC Bioinformatics. 2011 Jun 18; 12:246. Alexander DH, Lange K. PMID: 21682921; PMCID: PMC3146885.
      View in: PubMed   Mentions: 480     Fields:    Translation:Humans
    42. Linkage analysis without defined pedigrees. Genet Epidemiol. 2011 Jul; 35(5):360-70. Day-Williams AG, Blangero J, Dyer TD, Lange K, Sobel EM. PMID: 21465549; PMCID: PMC3290352.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    43. A quasi-Newton acceleration for high-dimensional optimization algorithms. Stat Comput. 2011 Jan 04; 21(2):261-273. Zhou H, Alexander D, Lange K. PMID: 21359052; PMCID: PMC3045213.
      View in: PubMed   Mentions: 56  
    44. A Fast Procedure for Calculating Importance Weights in Bootstrap Sampling. Comput Stat Data Anal. 2011 Jan 01; 55(1):26-33. Zhou H, Lange K. PMID: 21076658; PMCID: PMC2976546.
      View in: PubMed   Mentions: 1  
    45. RECONSTRUCTING DNA COPY NUMBER BY PENALIZED ESTIMATION AND IMPUTATION. Ann Appl Stat. 2010 Dec 01; 4(4):1749-1773. Zhang Z, Lange K, Ophoff R, Sabatti C. PMID: 21572975; PMCID: PMC3092301.
      View in: PubMed   Mentions: 9  
    46. On the Bumpy Road to the Dominant Mode. Scand Stat Theory Appl. 2010 Dec; 37(4):612-631. Zhou H, Lange KL. PMID: 21170287; PMCID: PMC3002233.
      View in: PubMed   Mentions: 7  
    47. MM Algorithms for Some Discrete Multivariate Distributions. J Comput Graph Stat. 2010 Sep 01; 19(3):645-665. Zhou H, Lange K. PMID: 20877446; PMCID: PMC2945396.
      View in: PubMed   Mentions: 13  
    48. Association screening of common and rare genetic variants by penalized regression. Bioinformatics. 2010 Oct 01; 26(19):2375-82. Zhou H, Sehl ME, Sinsheimer JS, Lange K. PMID: 20693321; PMCID: PMC3025646.
      View in: PubMed   Mentions: 72     Fields:    Translation:Humans
    49. Modeling maternal-offspring gene-gene interactions: the extended-MFG test. Genet Epidemiol. 2010 Jul; 34(5):512-21. Childs EJ, Palmer CG, Lange K, Sinsheimer JS. PMID: 20552637; PMCID: PMC3165170.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    50. A Poisson model for random multigraphs. Bioinformatics. 2010 Aug 15; 26(16):2004-11. Ranola JM, Ahn S, Sehl M, Smith DJ, Lange K. PMID: 20554690; PMCID: PMC3025746.
      View in: PubMed   Mentions: 6     Fields:    
    51. Prioritizing GWAS results: A review of statistical methods and recommendations for their application. Am J Hum Genet. 2010 Jan; 86(1):6-22. Cantor RM, Lange K, Sinsheimer JS. PMID: 20074509; PMCID: PMC2801749.
      View in: PubMed   Mentions: 306     Fields:    Translation:HumansAnimals
    52. Differential destruction of stem cells: implications for targeted cancer stem cell therapy. Cancer Res. 2009 Dec 15; 69(24):9481-9. Sehl ME, Sinsheimer JS, Zhou H, Lange KL. PMID: 19996291; PMCID: PMC2844253.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    53. Rating Movies and Rating the Raters Who Rate Them. Am Stat. 2009 Nov 01; 63(4):297-307. Zhou H, Lange K. PMID: 20802818; PMCID: PMC2929029.
      View in: PubMed   Mentions: 1  
    54. Accurate stochastic simulation via the step anticipation tau-leaping (SAL) algorithm. J Comput Biol. 2009 Sep; 16(9):1195-208. Sehl M, Alekseyenko AV, Lange KL. PMID: 19772431; PMCID: PMC3148118.
      View in: PubMed   Mentions: 8     Fields:    
    55. Fast model-based estimation of ancestry in unrelated individuals. Genome Res. 2009 Sep; 19(9):1655-64. Alexander DH, Novembre J, Lange K. PMID: 19648217; PMCID: PMC2752134.
      View in: PubMed   Mentions: 3321     Fields:    Translation:Humans
    56. Sharp Quadratic Majorization in One Dimension. Comput Stat Data Anal. 2009 May 15; 53(7):2471-2484. de Leeuw J, Lange K. PMID: 21738282; PMCID: PMC3129714.
      View in: PubMed   Mentions: 4  
    57. A heterozygote-homozygote test of Hardy-Weinberg equilibrium. Eur J Hum Genet. 2009 Nov; 17(11):1495-500. Zhou JJ, Lange K, Papp JC, Sinsheimer JS. PMID: 19367317; PMCID: PMC2986695.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    58. Penalized estimation of haplotype frequencies. Bioinformatics. 2008 Jul 15; 24(14):1596-602. Ayers KL, Lange K. PMID: 18487240.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    59. Fine mapping of regulatory loci for mammalian gene expression using radiation hybrids. Nat Genet. 2008 Apr; 40(4):421-9. Park CC, Ahn S, Bloom JS, Lin A, Wang RT, Wu T, Sekar A, Khan AH, Farr CJ, Lusis AJ, Leahy RM, Lange K, Smith DJ. PMID: 18362883; PMCID: PMC3014048.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    60. Bayesian Gaussian Mixture Models for High-Density Genotyping Arrays. J Am Stat Assoc. 2008 03 01; 103(481):89-100. Sabatti C, Lange K. PMID: 21572926; PMCID: PMC3092390.
      View in: PubMed   Mentions: 3  
    61. Estimating ethnic admixture from pedigree data. Am J Hum Genet. 2008 Mar; 82(3):748-55. Sinsheimer JS, Plaisier CL, Huertas-Vazquez A, Aguilar-Salinas C, Tusie-Luna T, Pajukanta P, Lange K. PMID: 18319077; PMCID: PMC2427215.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    62. A dictionary model for haplotyping, genotype calling, and association testing. Genet Epidemiol. 2007 Nov; 31(7):672-83. Ayers KL, Sabatti C, Lange K. PMID: 17487885.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    63. Merging microsatellite data. J Comput Biol. 2006 Jul-Aug; 13(6):1131-47. Presson AP, Sobel E, Lange K, Papp JC. PMID: 16901233.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    64. Variance component models for X-linked QTLs. Genet Epidemiol. 2006 Jul; 30(5):380-3. Lange K, Sobel E. PMID: 16671110.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    65. Accommodating chromosome inversions in linkage analysis. Am J Hum Genet. 2006 Aug; 79(2):238-51. Chen GK, Slaten E, Ophoff RA, Lange K. PMID: 16826515; PMCID: PMC1559487.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    66. Reconstructing ancestral haplotypes with a dictionary model. J Comput Biol. 2006 Apr; 13(3):767-85. Ayers KL, Sabatti C, Lange K. PMID: 16706724.
      View in: PubMed   Mentions: 1     Fields:    
    67. Association testing with Mendel. Genet Epidemiol. 2005 Jul; 29(1):36-50. Lange K, Sinsheimer JS, Sobel E. PMID: 15834862.
      View in: PubMed   Mentions: 43     Fields:    Translation:Humans
    68. Association testing in a linked region using large pedigrees. Am J Hum Genet. 2005 Mar; 76(3):538-42. Cantor RM, Chen GK, Pajukanta P, Lange K. PMID: 15657872; PMCID: PMC1196405.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    69. Vocabulon: a dictionary model approach for reconstruction and localization of transcription factor binding sites. Bioinformatics. 2005 Apr 01; 21(7):922-31. Sabatti C, Rohlin L, Lange K, Liao JC. PMID: 15509602.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    70. The pedigree trimming problem. Hum Hered. 2004; 58(2):108-11. Lange K, Sinsheimer JS. PMID: 15711090.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    71. Palmar hyperhidrosis: evidence of genetic transmission. J Vasc Surg. 2002 Feb; 35(2):382-6. Ro KM, Cantor RM, Lange KL, Ahn SS. PMID: 11854739.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansPHPublic Health
    72. Detection and integration of genotyping errors in statistical genetics. Am J Hum Genet. 2002 Feb; 70(2):496-508. Sobel E, Papp JC, Lange K. PMID: 11791215; PMCID: PMC384922.
      View in: PubMed   Mentions: 140     Fields:    Translation:Humans
    73. Spline methods for the comparison of physical and genetic maps. J Comput Biol. 2002; 9(3):465-75. Berloff N, Perola M, Lange K. PMID: 12162886.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
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