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Elizabeta Nemeth

Title(s)Professor, Medicine
SchoolMedicine
Address760 Westwood Plaza 32-144
Los Angeles CA 90024
Phone57499
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    Collapse Biography 
    Collapse Education and Training
    University of Belgrade, Belgrade, Yugoslavia B.S.1993 Molecular Biology and Physiology
    University of Hawaii, Honolulu, HI Ph.D.1998Cell, Molecular and Neurosciences
    Collapse Awards and Honors
    UCLA Health2020100 in 100 Recognition of Trailblazing Women in Honor of Women's Equality Day
    International BioIron Society2019Presidential Award
    European Hematology Association Meeting (Amsterdam)2019Plenary Presentation
    Cell Metabolism Series2016Women Leaders in the Field of Metabolism
    UCLA David Geffen School of Medicine2010  - 2019Outstanding Tutor Award
    American College of Nutrition2007Grace Goldsmith Award
    UCLA Department of Medicine Research Day2007Junior Faculty Award
    UCLA Department of Medicine Research Day2005Junior Faculty Award
    John A. Burns School of Medicine, University of Hawaii at Manoa1998Annual Biomedical Science Symposium Award for the Overall Best Presentation
    University of Hawaii at Manoa1998Tester Memorial Symposium, First Place Prize for the Best Research Paper Presented
    European Placenta Group/International Federation of Placenta Associations (Denmark)1997Olympus Microscope Award for the Best Poster
    University of Hawaii at Manoa1994  - 1995Kotobuki Scholarship

    Collapse Overview 
    Collapse Overview
    Elizabeta Nemeth is a Professor of Medicine at the David Geffen School of Medicine at UCLA, and Director of the UCLA Center for Iron Disorders. Dr. Nemeth received her BS in Molecular Biology at the University of Belgrade, Yugoslavia, and a PhD in Cell, Molecular and Neurosciences at the University of Hawaii. Since joining UCLA in 2002, Dr. Nemeth has been studying iron homeostasis and its disorders, with specific focus on the function of the hepatic peptide hormone hepcidin and its receptor/iron transporter ferroportin. Her work helped define the regulation of hepcidin production by iron, inflammation and erythropoiesis, described the role of hepcidin in different iron disorders including hereditary hemochromatosis, ß-thalassemia and anemia of inflammation, elucidated the mechanism of action of hepcidin as the ligand of ferroportin, described a novel hepcidin-regulating hormone erythroferrone, and developed novel hepcidin-targeted candidates for the treatment of iron disorders. Dr. Nemeth is also dedicated to translation of basic research and to this end has co-founded three biotechnology companies focused on hepcidin-targeted diagnostics and therapeutics.

    In 2007, Dr. Nemeth received the Grace Goldsmith Award from the American College of Nutrition for "significant achievements in the field of nutrition by a scientist under the age of 50 years", and in 2019, she received the Presidential Award of the International BioIron Society, for “seminal work on the mode of action of hepcidin and the molecular basis of systemic iron homeostasis”. Dr. Nemeth had served as a regular member of the NIH Molecular and Cellular Hematology Study Section and was elected President of the International Bioiron Society in 2019. She is also an associate editor of the American Journal of Hematology and a co-director of the UCLA K program for young faculty career development.

    Collapse Research 
    Collapse Research Activities and Funding
    Iron physiology and pathology in pregnancy
    NIH R01HD096863Jun 11, 2019 - Mar 31, 2024
    Role: Principal Investigator
    Erythroferrone and Its Impact on Maternal and Neonatal Iron Homeostasis
    NIH R21HD098864May 10, 2019 - Mar 31, 2021
    Role: Co-Principal Investigator
    Ferroportin Structure and function
    NIH R01DK107309Jul 1, 2015 - Apr 30, 2021
    Role: Principal Investigator
    The role of iron in atherosclerosis: application of new iron biology
    NIH R21HL106374Jan 1, 2011 - Nov 30, 2012
    Role: Principal Investigator
    The Hepcidin-Ferroportin Axis in Anemia of Inflammation: Mechanisms and Targets
    NIH R01DK082717Sep 30, 2008 - Jul 31, 2013
    Role: Principal Investigator
    REGULATION OF HEPCIDIN BY IRON AND OXYGEN
    NIH K01DK075378Aug 1, 2006 - Jun 3, 2009
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The hepcidin regulator erythroferrone is a new member of the erythropoiesis-iron-bone circuitry. Elife. 2021 May 18; 10. Castro-Mollo M, Gera S, Ruiz Martinez M, Feola M, Gumerova A, Planoutene M, Clementelli C, Sangkhae V, Casu C, Kim SM, Ostland V, Han H, Nemeth E, Fleming R, Rivella S, Lizneva D, Yuen T, Zaidi M, Ginzburg Y. PMID: 34002695.
      View in: PubMed   Mentions:    Fields:    
    2. Serum Erythroferrone During Pregnancy Is Related to Erythropoietin but Does Not Predict the Risk of Anemia. J Nutr. 2021 May 12. Delaney KM, Guillet R, Pressman EK, Ganz T, Nemeth E, O'Brien KO. PMID: 33982118.
      View in: PubMed   Mentions:    Fields:    
    3. INTERGROWTH-21 Identifies High Prevalence of Low Symphysis-Fundal Height in Indigenous Pregnant Women Experiencing Multiple Infections, Nutrient Deficiencies, and Inflammation: The Maternal Infections, Nutrient Deficiencies, and Inflammation (MINDI) Cohort. Curr Dev Nutr. 2021 Apr; 5(4):nzab012. González-Fernández D, Nemeth E, Pons EDC, Rueda D, Sinisterra OT, Murillo E, Sangkhae V, Starr LM, Scott ME, Koski KG. PMID: 33898918.
      View in: PubMed   Mentions:
    4. Pursuing Orally Bioavailable Hepcidin Analogues via Cyclic N-Methylated Mini-Hepcidins. Biomedicines. 2021 Feb 08; 9(2). Goncalves Monteiro D, van Dijk JWA, Aliyanto R, Fung E, Nemeth E, Ganz T, Rosengren J, Clark RJ. PMID: 33567510.
      View in: PubMed   Mentions:
    5. Isolation and thermal stabilization of mouse ferroportin. FEBS Open Bio. 2020 Nov 15. Deshpande CN, Azucenas CR, Qiao B, Nomura N, Xin V, Font J, Iwata S, Ganz T, Nemeth E, Mackenzie B, Jormakka M. PMID: 33190422.
      View in: PubMed   Mentions:    Fields:    
    6. Maternal hepcidin determines embryo iron homeostasis in mice. Blood. 2020 Nov 05; 136(19):2206-2216. Sangkhae V, Fisher AL, Chua KJ, Ruchala P, Ganz T, Nemeth E. PMID: 32584957.
      View in: PubMed   Mentions:    Fields:    
    7. Prognostic associations of plasma hepcidin in women with early breast cancer. Breast Cancer Res Treat. 2020 Dec; 184(3):927-935. Jerzak KJ, Lohmann AE, Ennis M, Nemeth E, Ganz T, Goodwin PJ. PMID: 32960376.
      View in: PubMed   Mentions:    Fields:    
    8. Clinical Immunoassay for Human Hepcidin Predicts Iron Deficiency in First-Time Blood Donors. J Appl Lab Med. 2020 09 01; 5(5):943-953. Gutschow P, Han H, Olbina G, Westerman K, Nemeth E, Ganz T, Copeland K, Westerman M, Ostland V. PMID: 32674118.
      View in: PubMed   Mentions: 1     Fields:    
    9. Iron overload causes a mild and transient increase in acute lung injury. Physiol Rep. 2020 06; 8(12):e14470. Zhang V, Ganz T, Nemeth E, Kim A. PMID: 32596989.
      View in: PubMed   Mentions:    Fields:    
    10. Author Correction: Identification of erythroferrone as an erythroid regulator of iron metabolism. Nat Genet. 2020 Apr; 52(4):463. Kautz L, Jung G, Valore EV, Rivella S, Nemeth E, Ganz T. PMID: 32107478.
      View in: PubMed   Mentions:    Fields:    
    11. Fetal and amniotic fluid iron homeostasis in healthy and complicated murine, macaque, and human pregnancy. JCI Insight. 2020 02 27; 5(4). Fisher AL, Sangkhae V, Presicce P, Chougnet CA, Jobe AH, Kallapur SG, Tabbah S, Buhimschi CS, Buhimschi IA, Ganz T, Nemeth E. PMID: 31990688.
      View in: PubMed   Mentions: 2     Fields:    
    12. Regulation of iron homeostasis through the erythroferrone-hepcidin axis in sickle cell disease. Br J Haematol. 2020 Jun; 189(6):1204-1209. Mangaonkar AA, Thawer F, Son J, Ajebo G, Xu H, Barrett NJ, Wells LG, Bowman L, Clair B, Patel N, Bora P, Jung G, Nemeth E, Kutlar A. PMID: 32030737.
      View in: PubMed   Mentions:    Fields:    
    13. Effects of maternal iron status on placental and fetal iron homeostasis. J Clin Invest. 2020 02 03; 130(2):625-640. Sangkhae V, Fisher AL, Wong S, Koenig MD, Tussing-Humphreys L, Chu A, Lelic M, Ganz T, Nemeth E. PMID: 31661462.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    14. Effects of erythropoietin on fibroblast growth factor 23 in mice and humans. Nephrol Dial Transplant. 2019 12 01; 34(12):2057-2065. Hanudel MR, Eisenga MF, Rappaport M, Chua K, Qiao B, Jung G, Gabayan V, Gales B, Ramos G, de Jong MA, van Zanden JJ, de Borst MH, Bakker SJL, Nemeth E, Salusky IB, Gaillard CAJM, Ganz T. PMID: 30007314.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    15. A variant erythroferrone disrupts iron homeostasis in SF3B1-mutated myelodysplastic syndrome. Sci Transl Med. 2019 07 10; 11(500). Bondu S, Alary AS, Lefèvre C, Houy A, Jung G, Lefebvre T, Rombaut D, Boussaid I, Bousta A, Guillonneau F, Perrier P, Alsafadi S, Wassef M, Margueron R, Rousseau A, Droin N, Cagnard N, Kaltenbach S, Winter S, Kubasch AS, Bouscary D, Santini V, Toma A, Hunault M, Stamatoullas A, Gyan E, Cluzeau T, Platzbecker U, Adès L, Puy H, Stern MH, Karim Z, Mayeux P, Nemeth E, Park S, Ganz T, Kautz L, Kosmider O, Fontenay M. PMID: 31292266.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    16. To induce or not to induce: the fight over hepcidin regulation. Haematologica. 2019 06; 104(6):1093-1095. Sangkhae V, Nemeth E. PMID: 31152085.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. Iron in Lung Pathology. Pharmaceuticals (Basel). 2019 Feb 15; 12(1). Zhang V, Nemeth E, Kim A. PMID: 30781366.
      View in: PubMed   Mentions:
    18. The Aftermath of Surviving Acute Radiation Hematopoietic Syndrome and its Mitigation. Radiat Res. 2019 04; 191(4):323-334. Micewicz ED, Iwamoto KS, Ratikan JA, Nguyen C, Xie MW, Cheng G, Boxx GM, Deriu E, Damoiseaux RD, Whitelegge JP, Ruchala PP, Avetisyan R, Jung ME, Lawson G, Nemeth E, Ganz T, Sayre JW, McBride WH, Schaue D. PMID: 30730284.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsPHPublic Health
    19. Increased gene copy number of DEFA1/DEFA3 worsens sepsis by inducing endothelial pyroptosis. Proc Natl Acad Sci U S A. 2019 02 19; 116(8):3161-3170. Chen Q, Yang Y, Hou J, Shu Q, Yin Y, Fu W, Han F, Hou T, Zeng C, Nemeth E, Linzmeier R, Ganz T, Fang X. PMID: 30718392.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    20. Hepatic hepcidin/intestinal HIF-2a axis maintains iron absorption during iron deficiency and overload. J Clin Invest. 2019 01 02; 129(1):336-348. Schwartz AJ, Das NK, Ramakrishnan SK, Jain C, Jurkovic MT, Wu J, Nemeth E, Lakhal-Littleton S, Colacino JA, Shah YM. PMID: 30352047.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    21. Iron homeostasis in pregnancy and spontaneous abortion. Am J Hematol. 2019 02; 94(2):184-188. Guo Y, Zhang N, Zhang D, Ren Q, Ganz T, Liu S, Nemeth E. PMID: 30394565.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    22. Mechanisms responsible for reduced erythropoiesis during androgen deprivation therapy in men with prostate cancer. Am J Physiol Endocrinol Metab. 2018 12 01; 315(6):E1185-E1193. Gagliano-Jucá T, Pencina KM, Ganz T, Travison TG, Kantoff PW, Nguyen PL, Taplin ME, Kibel AS, Li Z, Huang G, Edwards RR, Nemeth E, Basaria S. PMID: 30325657.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    23. Erythroferrone is not required for the glucoregulatory and hematologic effects of chronic erythropoietin treatment in mice. Physiol Rep. 2018 09; 6(19):e13890. Coffey R, Sardo U, Kautz L, Gabayan V, Nemeth E, Ganz T. PMID: 30315639.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    24. Calcium is an essential cofactor for metal efflux by the ferroportin transporter family. Nat Commun. 2018 08 06; 9(1):3075. Deshpande CN, Ruwe TA, Shawki A, Xin V, Vieth KR, Valore EV, Qiao B, Ganz T, Nemeth E, Mackenzie B, Jormakka M. PMID: 30082682.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    25. Placental iron transport: The mechanism and regulatory circuits. Free Radic Biol Med. 2019 03; 133:254-261. Sangkhae V, Nemeth E. PMID: 29981833.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    26. Hepcidin Protects against Lethal Escherichia coli Sepsis in Mice Inoculated with Isolates from Septic Patients. Infect Immun. 2018 07; 86(7). Stefanova D, Raychev A, Deville J, Humphries R, Campeau S, Ruchala P, Nemeth E, Ganz T, Bulut Y. PMID: 29735522.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    27. Therapeutic recommendations in HFE hemochromatosis for p.Cys282Tyr (C282Y/C282Y) homozygous genotype. Hepatol Int. 2018 Mar; 12(2):83-86. Adams P, Altes A, Brissot P, Butzeck B, Cabantchik I, Cançado R, Distante S, Evans P, Evans R, Ganz T, Girelli D, Hultcrantz R, McLaren G, Marris B, Milman N, Nemeth E, Nielsen P, Pineau B, Piperno A, Porto G, Prince D, Ryan J, Sanchez M, Santos P, Swinkels D, Teixeira E, Toska K, Vanclooster A, White D. PMID: 29589198.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    28. Fetal presentation of congenital dyserythropoietic anemia type 1 with novel compound heterozygous CDAN1 mutations. Blood Cells Mol Dis. 2018 07; 71:63-66. Meznarich JA, Draper L, Christensen RD, Yaish HM, Luem ND, Pysher TJ, Jung G, Nemeth E, Ganz T, Ward DM. PMID: 29599085.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    29. Hepcidin agonists as therapeutic tools. Blood. 2018 04 19; 131(16):1790-1794. Casu C, Nemeth E, Rivella S. PMID: 29523504.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    30. Levels of the erythropoietin-responsive hormone erythroferrone in mice and humans with chronic kidney disease. Haematologica. 2018 04; 103(4):e141-e142. Hanudel MR, Rappaport M, Chua K, Gabayan V, Qiao B, Jung G, Salusky IB, Ganz T, Nemeth E. PMID: 29419424.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    31. Structure-function analysis of ferroportin defines the binding site and an alternative mechanism of action of hepcidin. Blood. 2018 02 22; 131(8):899-910. Aschemeyer S, Qiao B, Stefanova D, Valore EV, Sek AC, Ruwe TA, Vieth KR, Jung G, Casu C, Rivella S, Jormakka M, Mackenzie B, Ganz T, Nemeth E. PMID: 29237594.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    32. Iron homeostasis during pregnancy. Am J Clin Nutr. 2017 Dec; 106(Suppl 6):1567S-1574S. Fisher AL, Nemeth E. PMID: 29070542.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    33. In a Mouse Model of Sepsis, Hepcidin Ablation Ameliorates Anemia More Effectively than Iron and Erythropoietin Treatment. Shock. 2017 10; 48(4):490-497. Khorramian E, Fung E, Chua K, Gabayan V, Ganz T, Nemeth E, Kim A. PMID: 28452907.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    34. Erythropoietin stimulates murine and human fibroblast growth factor-23, revealing novel roles for bone and bone marrow. Haematologica. 2017 11; 102(11):e427-e430. Clinkenbeard EL, Hanudel MR, Stayrook KR, Appaiah HN, Farrow EG, Cass TA, Summers LJ, Ip CS, Hum JM, Thomas JC, Ivan M, Richine BM, Chan RJ, Clemens TL, Schipani E, Sabbagh Y, Xu L, Srour EF, Alvarez MB, Kacena MA, Salusky IB, Ganz T, Nemeth E, White KE. PMID: 28818868.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    35. Hamp1 mRNA and plasma hepcidin levels are influenced by sex and strain but do not predict tissue iron levels in inbred mice. Am J Physiol Gastrointest Liver Physiol. 2017 Nov 01; 313(5):G511-G523. McLachlan S, Page KE, Lee SM, Loguinov A, Valore E, Hui ST, Jung G, Zhou J, Lusis AJ, Fuqua B, Ganz T, Nemeth E, Vulpe CD. PMID: 28798083.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    36. Immunoassay for human serum erythroferrone. Blood. 2017 09 07; 130(10):1243-1246. Ganz T, Jung G, Naeim A, Ginzburg Y, Pakbaz Z, Walter PB, Kautz L, Nemeth E. PMID: 28739636.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    37. Endogenous hepcidin and its agonist mediate resistance to selected infections by clearing non-transferrin-bound iron. Blood. 2017 07 20; 130(3):245-257. Stefanova D, Raychev A, Arezes J, Ruchala P, Gabayan V, Skurnik M, Dillon BJ, Horwitz MA, Ganz T, Bulut Y, Nemeth E. PMID: 28465342.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    38. Hepcidin-mediated iron sequestration protects against bacterial dissemination during pneumonia. JCI Insight. 2017 03 23; 2(6):e92002. Michels KR, Zhang Z, Bettina AM, Cagnina RE, Stefanova D, Burdick MD, Vaulont S, Nemeth E, Ganz T, Mehrad B. PMID: 28352667.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    39. Erythroferrone and matriptase-2 independently regulate hepcidin expression. Am J Hematol. 2017 05; 92(5):E61-E63. Aschemeyer S, Gabayan V, Ganz T, Nemeth E, Kautz L. PMID: 28187515.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    40. Regulation of the Iron Homeostatic Hormone Hepcidin. Adv Nutr. 2017 01; 8(1):126-136. Sangkhae V, Nemeth E. PMID: 28096133.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    41. Increased serum hepcidin contributes to the anemia of chronic kidney disease in a murine model. Haematologica. 2017 03; 102(3):e85-e88. Hanudel MR, Rappaport M, Gabayan V, Jung G, Salusky IB, Nemeth E, Ganz T, Zaritsky J. PMID: 27884972.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    42. Iron Metabolism in African American Women in the Second and Third Trimesters of High-Risk Pregnancies. J Obstet Gynecol Neonatal Nurs. 2017 Jan - Feb; 46(1):148-158. Welke L, Koenig MD, Thomson JL, Nemeth E, White-Traut R, McFarlin BL, Giurgescu C, Engeland CG, Kominiarek MA, Tussing-Humphreys L. PMID: 27836659.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    43. Effects of dietary iron intake and chronic kidney disease on fibroblast growth factor 23 metabolism in wild-type and hepcidin knockout mice. Am J Physiol Renal Physiol. 2016 12 01; 311(6):F1369-F1377. Hanudel MR, Chua K, Rappaport M, Gabayan V, Valore E, Goltzman D, Ganz T, Nemeth E, Salusky IB. PMID: 27733366.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    44. Minihepcidin peptides as disease modifiers in mice affected by ß-thalassemia and polycythemia vera. Blood. 2016 07 14; 128(2):265-76. Casu C, Oikonomidou PR, Chen H, Nandi V, Ginzburg Y, Prasad P, Fleming RE, Shah YM, Valore EV, Nemeth E, Ganz T, MacDonald B, Rivella S. PMID: 27154187.
      View in: PubMed   Mentions: 33     Fields:    Translation:Animals
    45. Hepcidin in the diagnosis of iron disorders. Blood. 2016 06 09; 127(23):2809-13. Girelli D, Nemeth E, Swinkels DW. PMID: 27044621.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimals
    46. Iron Balance and the Role of Hepcidin in Chronic Kidney Disease. Semin Nephrol. 2016 03; 36(2):87-93. Ganz T, Nemeth E. PMID: 27236128.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    47. Ironing out Ferroportin. Cell Metab. 2015 Nov 03; 22(5):777-87. Drakesmith H, Nemeth E, Ganz T. PMID: 26437604.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    48. Isocitrate treatment of acute anemia of inflammation in a mouse model. Blood Cells Mol Dis. 2016 Jan; 56(1):31-6. Kim A, Fung E, Parikh SG, Gabayan V, Nemeth E, Ganz T. PMID: 26603720.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    49. Hepcidin and Host Defense against Infectious Diseases. PLoS Pathog. 2015 Aug; 11(8):e1004998. Michels K, Nemeth E, Ganz T, Mehrad B. PMID: 26291319.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimals
    50. Erythroferrone contributes to hepcidin suppression and iron overload in a mouse model of ß-thalassemia. Blood. 2015 Oct 22; 126(17):2031-7. Kautz L, Jung G, Du X, Gabayan V, Chapman J, Nasoff M, Nemeth E, Ganz T. PMID: 26276665.
      View in: PubMed   Mentions: 57     Fields:    Translation:Animals
    51. Iron homeostasis in host defence and inflammation. Nat Rev Immunol. 2015 Aug; 15(8):500-10. Ganz T, Nemeth E. PMID: 26160612.
      View in: PubMed   Mentions: 135     Fields:    Translation:HumansAnimalsCells
    52. New insights into iron regulation and erythropoiesis. Curr Opin Hematol. 2015 May; 22(3):199-205. Kim A, Nemeth E. PMID: 25710710.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    53. Evidence that the expression of transferrin receptor 1 on erythroid marrow cells mediates hepcidin suppression in the liver. Exp Hematol. 2015 Jun; 43(6):469-78.e6. Keel SB, Doty R, Liu L, Nemeth E, Cherian S, Ganz T, Abkowitz JL. PMID: 25782630.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    54. Small cyclic agonists of iron regulatory hormone hepcidin. Bioorg Med Chem Lett. 2015 Nov 01; 25(21):4961-4969. Chua K, Fung E, Micewicz ED, Ganz T, Nemeth E, Ruchala P. PMID: 25813158.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    55. Hepcidin-induced hypoferremia is a critical host defense mechanism against the siderophilic bacterium Vibrio vulnificus. . 2015 Jan 14; 17(1):47-57. Arezes J, Jung G, Gabayan V, Valore E, Ruchala P, Gulig PA, Ganz T, Nemeth E, Bulut Y. PMID: 25590758.
      View in: PubMed   Mentions:
    56. Thiol-derivatized minihepcidins retain biological activity. Bioorg Med Chem Lett. 2015 Feb 15; 25(4):763-6. Fung E, Chua K, Ganz T, Nemeth E, Ruchala P. PMID: 25599838.
      View in: PubMed   Mentions: 7     Fields:    
    57. A competitive enzyme-linked immunosorbent assay specific for murine hepcidin-1: correlation with hepatic mRNA expression in established and novel models of dysregulated iron homeostasis. Haematologica. 2015 Feb; 100(2):167-77. Gutschow P, Schmidt PJ, Han H, Ostland V, Bartnikas TB, Pettiglio MA, Herrera C, Butler JS, Nemeth E, Ganz T, Fleming MD, Westerman M. PMID: 25425686.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    58. Erythroferrone contributes to recovery from anemia of inflammation. Blood. 2014 Oct 16; 124(16):2569-74. Kautz L, Jung G, Nemeth E, Ganz T. PMID: 25193872.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    59. Hepcidin and iron homeostasis during pregnancy. Nutrients. 2014 Aug 04; 6(8):3062-83. Koenig MD, Tussing-Humphreys L, Day J, Cadwell B, Nemeth E. PMID: 25093277.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimals
    60. Disordered hepcidin-ferroportin signaling promotes breast cancer growth. Cell Signal. 2014 Nov; 26(11):2539-50. Zhang S, Chen Y, Guo W, Yuan L, Zhang D, Xu Y, Nemeth E, Ganz T, Liu S. PMID: 25093806.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    61. Identification of erythroferrone as an erythroid regulator of iron metabolism. Nat Genet. 2014 Jul; 46(7):678-84. Kautz L, Jung G, Valore EV, Rivella S, Nemeth E, Ganz T. PMID: 24880340.
      View in: PubMed   Mentions: 243     Fields:    Translation:Animals
    62. Molecular liaisons between erythropoiesis and iron metabolism. Blood. 2014 Jul 24; 124(4):479-82. Kautz L, Nemeth E. PMID: 24876565.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    63. Anemia of inflammation. Hematol Oncol Clin North Am. 2014 Aug; 28(4):671-81, vi. Nemeth E, Ganz T. PMID: 25064707.
      View in: PubMed   Mentions: 80     Fields:    Translation:Humans
    64. Systemic and tumor level iron regulation in men with colorectal cancer: a case control study. Nutr Metab (Lond). 2014; 11:21. Pusatcioglu CK, Nemeth E, Fantuzzi G, Llor X, Freels S, Tussing-Humphreys L, Cabay RJ, Linzmeier R, Ng D, Clark J, Braunschweig C. PMID: 24872837.
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    65. Mouse models of anemia of cancer. PLoS One. 2014; 9(3):e93283. Kim A, Rivera S, Shprung D, Limbrick D, Gabayan V, Nemeth E, Ganz T. PMID: 24681760.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    66. The pathophysiology and pharmacology of hepcidin. Trends Pharmacol Sci. 2014 Mar; 35(3):155-61. Ruchala P, Nemeth E. PMID: 24552640.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimals
    67. Total synthesis of human hepcidin through regioselective disulfide-bond formation by using the safety-catch cysteine protecting group 4,4'-dimethylsulfinylbenzhydryl. Angew Chem Int Ed Engl. 2014 Mar 10; 53(11):2931-4. Dekan Z, Mobli M, Pennington MW, Fung E, Nemeth E, Alewood PF. PMID: 24604812.
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    68. A mouse model of anemia of inflammation: complex pathogenesis with partial dependence on hepcidin. Blood. 2014 Feb 20; 123(8):1129-36. Kim A, Fung E, Parikh SG, Valore EV, Gabayan V, Nemeth E, Ganz T. PMID: 24357728.
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    69. Testing the iron hypothesis in a mouse model of atherosclerosis. Cell Rep. 2013 Dec 12; 5(5):1436-42. Kautz L, Gabayan V, Wang X, Wu J, Onwuzurike J, Jung G, Qiao B, Lusis AJ, Ganz T, Nemeth E. PMID: 24316081.
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    70. Functional properties of human ferroportin, a cellular iron exporter reactive also with cobalt and zinc. . 2014 Mar 01; 306(5):C450-9. Mitchell CJ, Shawki A, Ganz T, Nemeth E, Mackenzie B. PMID: 24304836.
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    71. Hepcidin induction by pathogens and pathogen-derived molecules is strongly dependent on interleukin-6. Infect Immun. 2014 Feb; 82(2):745-52. Rodriguez R, Jung CL, Gabayan V, Deng JC, Ganz T, Nemeth E, Bulut Y. PMID: 24478088.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    72. Manipulation of the hepcidin pathway for therapeutic purposes. Haematologica. 2013 Nov; 98(11):1667-76. Fung E, Nemeth E. PMID: 24186312.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    73. Design, synthesis, and characterization of cyclic analogues of the iron regulatory peptide hormone hepcidin. Biopolymers. 2013 Sep; 100(5):519-26. Clark RJ, Preza GC, Tan CC, van Dijk JW, Fung E, Nemeth E, Ganz T, Craik DJ. PMID: 23897622.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    74. Hepcidin and ß-thalassemia major. Blood. 2013 Jul 04; 122(1):3-4. Nemeth E. PMID: 23828883.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    75. Cellular catabolism of the iron-regulatory peptide hormone hepcidin. PLoS One. 2013; 8(3):e58934. Preza GC, Pinon R, Ganz T, Nemeth E. PMID: 23536837.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    76. Testosterone administration inhibits hepcidin transcription and is associated with increased iron incorporation into red blood cells. Aging Cell. 2013 Apr; 12(2):280-91. Guo W, Bachman E, Li M, Roy CN, Blusztajn J, Wong S, Chan SY, Serra C, Jasuja R, Travison TG, Muckenthaler MU, Nemeth E, Bhasin S. PMID: 23399021.
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    77. Hepcidin level predicts hemoglobin concentration in individuals undergoing repeated phlebotomy. Haematologica. 2013 Aug; 98(8):1324-30. Mast AE, Schlumpf KS, Wright DJ, Johnson B, Glynn SA, Busch MP, Olbina G, Westerman M, Nemeth E, Ganz T, NHLBI Retrovirus Epidemiology Donor Study-II (REDS-II) . PMID: 23445875.
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    78. High-throughput screening of small molecules identifies hepcidin antagonists. Mol Pharmacol. 2013 Mar; 83(3):681-90. Fung E, Sugianto P, Hsu J, Damoiseaux R, Ganz T, Nemeth E. PMID: 23292796.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    79. Hepcidin is a key mediator of anemia of inflammation in Crohn's disease. J Crohns Colitis. 2013 Sep; 7(8):e286-91. Basseri RJ, Nemeth E, Vassilaki ME, Basseri B, Enayati P, Shaye O, Bourikas LA, Ganz T, Papadakis KA. PMID: 23219355.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    80. Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis. Blood. 2012 Nov 01; 120(18):3829-36. Ramos E, Ruchala P, Goodnough JB, Kautz L, Preza GC, Nemeth E, Ganz T. PMID: 22990014.
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    81. Iron homeostasis and its disorders in mice and men: potential lessons for rhinos. J Zoo Wildl Med. 2012 Sep; 43(3 Suppl):S19-26. Ganz T, Nemeth E. PMID: 23156702.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    82. IOD in rhinos--immunity group report: report from the Immunity, Genetics and Toxicology Working Group of the International Workshop on Iron Overload Disorder in Browsing Rhinoceros (February 2011). J Zoo Wildl Med. 2012 Sep; 43(3 Suppl):S117-9. Ganz T, Goff J, Klasing K, Nemeth E, Roth T. PMID: 23156715.
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    83. Inhibition of hepcidin transcription by growth factors. Hepatology. 2012 Jul; 56(1):291-9. Goodnough JB, Ramos E, Nemeth E, Ganz T. PMID: 22278715.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    84. Molecular mechanism of hepcidin-mediated ferroportin internalization requires ferroportin lysines, not tyrosines or JAK-STAT. Cell Metab. 2012 Jun 06; 15(6):905-17. Ross SL, Tran L, Winters A, Lee KJ, Plewa C, Foltz I, King C, Miranda LP, Allen J, Beckman H, Cooke KS, Moody G, Sasu BJ, Nemeth E, Ganz T, Molineux G, Arvedson TL. PMID: 22682226.
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    85. Hepcidin-induced endocytosis of ferroportin is dependent on ferroportin ubiquitination. Cell Metab. 2012 Jun 06; 15(6):918-24. Qiao B, Sugianto P, Fung E, Del-Castillo-Rueda A, Moran-Jimenez MJ, Ganz T, Nemeth E. PMID: 22682227.
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    86. Iron metabolism: interactions with normal and disordered erythropoiesis. Cold Spring Harb Perspect Med. 2012 May; 2(5):a011668. Ganz T, Nemeth E. PMID: 22553501.
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    87. Rethinking iron regulation and assessment in iron deficiency, anemia of chronic disease, and obesity: introducing hepcidin. J Acad Nutr Diet. 2012 Mar; 112(3):391-400. Tussing-Humphreys L, Pusatcioglu C, Pustacioglu C, Nemeth E, Braunschweig C. PMID: 22717199.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansPHPublic Health
    88. Hepcidin and iron homeostasis. Biochim Biophys Acta. 2012 Sep; 1823(9):1434-43. Ganz T, Nemeth E. PMID: 22306005.
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    89. Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload. J Clin Invest. 2011 Dec; 121(12):4880-8. Preza GC, Ruchala P, Pinon R, Ramos E, Qiao B, Peralta MA, Sharma S, Waring A, Ganz T, Nemeth E. PMID: 22045566.
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    90. Subcutaneous adipose tissue from obese and lean adults does not release hepcidin in vivo. ScientificWorldJournal. 2011; 11:2197-206. Tussing-Humphreys L, Frayn KN, Smith SR, Westerman M, Dennis AL, Nemeth E, Thomson J, Pusatcioglu C. PMID: 22125467.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    91. Serum hepcidin as a diagnostic test of iron deficiency in premenopausal female blood donors. Haematologica. 2011 Aug; 96(8):1099-105. Pasricha SR, McQuilten Z, Westerman M, Keller A, Nemeth E, Ganz T, Wood E. PMID: 21508121.
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    92. Hepcidin response to acute iron intake and chronic iron loading in dysmetabolic iron overload syndrome. Liver Int. 2011 Aug; 31(7):994-1000. Trombini P, Paolini V, Pelucchi S, Mariani R, Nemeth E, Ganz T, Piperno A. PMID: 21733088.
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    93. Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice. Hepatology. 2011 Apr; 53(4):1333-41. Ramos E, Kautz L, Rodriguez R, Hansen M, Gabayan V, Ginzburg Y, Roth MP, Nemeth E, Ganz T. PMID: 21480335.
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    94. Understanding the structure/activity relationships of the iron regulatory peptide hepcidin. Chem Biol. 2011 Mar 25; 18(3):336-43. Clark RJ, Tan CC, Preza GC, Nemeth E, Ganz T, Craik DJ. PMID: 21439478.
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    95. Hepcidin and disorders of iron metabolism. Annu Rev Med. 2011; 62:347-60. Ganz T, Nemeth E. PMID: 20887198.
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    96. The hepcidin-ferroportin system as a therapeutic target in anemias and iron overload disorders. Hematology Am Soc Hematol Educ Program. 2011; 2011:538-42. Ganz T, Nemeth E. PMID: 22160086.
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    97. A time course of hepcidin response to iron challenge in patients with HFE and TFR2 hemochromatosis. Haematologica. 2011 Apr; 96(4):500-6. Girelli D, Trombini P, Busti F, Campostrini N, Sandri M, Pelucchi S, Westerman M, Ganz T, Nemeth E, Piperno A, Camaschella C. PMID: 21173098.
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    98. Novel tools for the evaluation of iron metabolism. Haematologica. 2010 Dec; 95(12):1989-91. Kautz L, Nemeth E. PMID: 21123438.
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    99. Hepcidin as a therapeutic tool to limit iron overload and improve anemia in ß-thalassemic mice. J Clin Invest. 2010 Dec; 120(12):4466-77. Gardenghi S, Ramos P, Marongiu MF, Melchiori L, Breda L, Guy E, Muirhead K, Rao N, Roy CN, Andrews NC, Nemeth E, Follenzi A, An X, Mohandas N, Ginzburg Y, Rachmilewitz EA, Giardina PJ, Grady RW, Rivella S. PMID: 21099112.
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    100. Detection, evaluation, and management of iron-restricted erythropoiesis. Blood. 2010 Dec 02; 116(23):4754-61. Goodnough LT, Nemeth E, Ganz T. PMID: 20826717.
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    101. In anemia of multiple myeloma, hepcidin is induced by increased bone morphogenetic protein 2. Blood. 2010 Nov 04; 116(18):3635-44. Maes K, Nemeth E, Roodman GD, Huston A, Esteve F, Freytes C, Callander N, Katodritou E, Tussing-Humphreys L, Rivera S, Vanderkerken K, Lichtenstein A, Ganz T. PMID: 20679527.
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    102. Hepcidin in beta-thalassemia. Ann N Y Acad Sci. 2010 Aug; 1202:31-5. Nemeth E. PMID: 20712769.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    103. Alpha 1-acid glycoprotein, hepcidin, C-reactive protein, and serum ferritin are correlated in anemic schoolchildren with Schistosoma haematobium. Am J Clin Nutr. 2010 Jun; 91(6):1784-90. Ayoya MA, Spiekermann-Brouwer GM, Stoltzfus RJ, Nemeth E, Habicht JP, Ganz T, Rawat R, Traoré AK, Garza C. PMID: 20410090.
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    104. Hepcidin biology and therapeutic applications. Expert Rev Hematol. 2010 Apr; 3(2):153-5. Nemeth E. PMID: 21083458.
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    105. Reduction of serum hepcidin by hemodialysis in pediatric and adult patients. Clin J Am Soc Nephrol. 2010 Jun; 5(6):1010-4. Zaritsky J, Young B, Gales B, Wang HJ, Rastogi A, Westerman M, Nemeth E, Ganz T, Salusky IB. PMID: 20299375.
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    106. Proinflammatory state, hepcidin, and anemia in older persons. Blood. 2010 May 06; 115(18):3810-6. Ferrucci L, Semba RD, Guralnik JM, Ershler WB, Bandinelli S, Patel KV, Sun K, Woodman RC, Andrews NC, Cotter RJ, Ganz T, Nemeth E, Longo DL. PMID: 20081092.
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    107. Decreased serum hepcidin and improved functional iron status 6 months after restrictive bariatric surgery. Obesity (Silver Spring). 2010 Oct; 18(10):2010-6. Tussing-Humphreys LM, Nemeth E, Fantuzzi G, Freels S, Holterman AX, Galvani C, Ayloo S, Vitello J, Braunschweig C. PMID: 20075851.
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    108. The role of hepcidin in iron metabolism. Acta Haematol. 2009; 122(2-3):78-86. Nemeth E, Ganz T. PMID: 19907144.
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    109. Elevated systemic hepcidin and iron depletion in obese premenopausal females. Obesity (Silver Spring). 2010 Jul; 18(7):1449-56. Tussing-Humphreys LM, Nemeth E, Fantuzzi G, Freels S, Guzman G, Holterman AX, Braunschweig C. PMID: 19816411.
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    110. Iron sequestration and anemia of inflammation. Semin Hematol. 2009 Oct; 46(4):387-93. Ganz T, Nemeth E. PMID: 19786207.
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    111. Reduced serum hepcidin levels in patients with chronic hepatitis C. J Hepatol. 2009 Nov; 51(5):845-52. Girelli D, Pasino M, Goodnough JB, Nemeth E, Guido M, Castagna A, Busti F, Campostrini N, Martinelli N, Vantini I, Corrocher R, Ganz T, Fattovich G. PMID: 19729219.
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    112. Hereditary hemochromatosis due to resistance to hepcidin: high hepcidin concentrations in a family with C326S ferroportin mutation. Blood. 2009 Jul 09; 114(2):493-4. Sham RL, Phatak PD, Nemeth E, Ganz T. PMID: 19589941.
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    113. Hepcidin--a potential novel biomarker for iron status in chronic kidney disease. Clin J Am Soc Nephrol. 2009 Jun; 4(6):1051-6. Zaritsky J, Young B, Wang HJ, Westerman M, Olbina G, Nemeth E, Ganz T, Rivera S, Nissenson AR, Salusky IB. PMID: 19406957.
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    114. The molecular basis of hepcidin-resistant hereditary hemochromatosis. Blood. 2009 Jul 09; 114(2):437-43. Fernandes A, Preza GC, Phung Y, De Domenico I, Kaplan J, Ganz T, Nemeth E. PMID: 19383972.
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    115. Iron absorption in dysmetabolic iron overload syndrome is decreased and correlates with increased plasma hepcidin. J Hepatol. 2009 Jun; 50(6):1219-25. Ruivard M, Lainé F, Ganz T, Olbina G, Westerman M, Nemeth E, Rambeau M, Mazur A, Gerbaud L, Tournilhac V, Abergel A, Philippe P, Deugnier Y, Coudray C. PMID: 19398238.
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    116. Daily regulation of serum and urinary hepcidin is not influenced by submaximal cycling exercise in humans with normal iron metabolism. Eur J Appl Physiol. 2009 Jun; 106(3):435-43. Troadec MB, Lainé F, Daniel V, Rochcongar P, Ropert M, Cabillic F, Perrin M, Morcet J, Loréal O, Olbina G, Westerman M, Nemeth E, Ganz T, Brissot P. PMID: 19306018.
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    117. Excess adiposity, inflammation, and iron-deficiency in female adolescents. J Am Diet Assoc. 2009 Feb; 109(2):297-302. Tussing-Humphreys LM, Liang H, Nemeth E, Freels S, Braunschweig CA. PMID: 19167957.
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    118. Immunoassay for human serum hepcidin. Blood. 2008 Nov 15; 112(10):4292-7. Ganz T, Olbina G, Girelli D, Nemeth E, Westerman M. PMID: 18689548.
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    119. The hepcidin-binding site on ferroportin is evolutionarily conserved. Cell Metab. 2008 Aug; 8(2):146-56. De Domenico I, Nemeth E, Nelson JM, Phillips JD, Ajioka RS, Kay MS, Kushner JP, Ganz T, Ward DM, Kaplan J. PMID: 18680715.
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    120. Involvement of hepcidin in the anemia of multiple myeloma. Clin Cancer Res. 2008 Jun 01; 14(11):3262-7. Sharma S, Nemeth E, Chen YH, Goodnough J, Huston A, Roodman GD, Ganz T, Lichtenstein A. PMID: 18519751.
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    121. Urinary hepcidin excretion in patients with myelodysplastic syndrome and myelofibrosis. Br J Haematol. 2008 Aug; 142(4):669-71. Winder A, Lefkowitz R, Ghoti H, Leiba M, Ganz T, Nemeth E, Rachmilewitz EA. PMID: 18498424.
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    122. Iron regulation and erythropoiesis. Curr Opin Hematol. 2008 May; 15(3):169-75. Nemeth E. PMID: 18391780.
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    123. Hepcidin and iron-related gene expression in subjects with Dysmetabolic Hepatic Iron Overload. J Hepatol. 2008 Jul; 49(1):123-33. Barisani D, Pelucchi S, Mariani R, Galimberti S, Trombini P, Fumagalli D, Meneveri R, Nemeth E, Ganz T, Piperno A. PMID: 18462824.
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    124. Measurement of urinary hepcidin levels by SELDI-TOF-MS in HFE-hemochromatosis. Blood Cells Mol Dis. 2008 May-Jun; 40(3):347-52. Bozzini C, Campostrini N, Trombini P, Nemeth E, Castagna A, Tenuti I, Corrocher R, Camaschella C, Ganz T, Olivieri O, Piperno A, Girelli D. PMID: 18164223.
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    125. Effects of plasma transfusion on hepcidin production in human congenital hypotransferrinemia. Haematologica. 2007 Oct; 92(10):1407-10. Trombini P, Coliva T, Nemeth E, Mariani R, Ganz T, Biondi A, Piperno A. PMID: 17768112.
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    126. Soluble hemojuvelin is released by proprotein convertase-mediated cleavage at a conserved polybasic RNRR site. Blood Cells Mol Dis. 2008 Jan-Feb; 40(1):122-31. Lin L, Nemeth E, Goodnough JB, Thapa DR, Gabayan V, Ganz T. PMID: 17869549.
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    127. Blunted hepcidin response to oral iron challenge in HFE-related hemochromatosis. Blood. 2007 Dec 01; 110(12):4096-100. Piperno A, Girelli D, Nemeth E, Trombini P, Bozzini C, Poggiali E, Phung Y, Ganz T, Camaschella C. PMID: 17724144.
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    128. Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4. Blood. 2007 Sep 15; 110(6):2182-9. Lin L, Valore EV, Nemeth E, Goodnough JB, Gabayan V, Ganz T. PMID: 17540841.
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    129. The molecular mechanism of hepcidin-mediated ferroportin down-regulation. Mol Biol Cell. 2007 Jul; 18(7):2569-78. De Domenico I, Ward DM, Langelier C, Vaughn MB, Nemeth E, Sundquist WI, Ganz T, Musci G, Kaplan J. PMID: 17475779.
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    130. Liver iron concentrations and urinary hepcidin in beta-thalassemia. Haematologica. 2007 May; 92(5):583-8. Origa R, Galanello R, Ganz T, Giagu N, Maccioni L, Faa G, Nemeth E. PMID: 17488680.
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    131. Urinary hepcidin in congenital chronic anemias. Pediatr Blood Cancer. 2007 Jan; 48(1):57-63. Kearney SL, Nemeth E, Neufeld EJ, Thapa D, Ganz T, Weinstein DA, Cunningham MJ. PMID: 16220548.
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    132. Molecular and clinical correlates in iron overload associated with mutations in ferroportin. Haematologica. 2006 Aug; 91(8):1092-5. De Domenico I, McVey Ward D, Nemeth E, Ganz T, Corradini E, Ferrara F, Musci G, Pietrangelo A, Kaplan J. PMID: 16885049.
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    133. DMT1 mutation: response of anemia to darbepoetin administration and implications for iron homeostasis. Blood. 2006 Jul 01; 108(1):404-5. Pospisilova D, Mims MP, Nemeth E, Ganz T, Prchal JT. PMID: 16790587.
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    134. Hepcidin and iron-loading anemias. Haematologica. 2006 Jun; 91(6):727-32. Nemeth E, Ganz T. PMID: 16769573.
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    135. Regulation of iron acquisition and iron distribution in mammals. Biochim Biophys Acta. 2006 Jul; 1763(7):690-9. Ganz T, Nemeth E. PMID: 16790283.
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    136. Arsenite pre-conditioning reduces UVB-induced apoptosis in corneal epithelial cells through the anti-apoptotic activity of 27 kDa heat shock protein (HSP27). J Cell Physiol. 2006 Feb; 206(2):301-8. Shi B, Isseroff RR. PMID: 16141345.
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    137. Iron imports. IV. Hepcidin and regulation of body iron metabolism. Am J Physiol Gastrointest Liver Physiol. 2006 Feb; 290(2):G199-203. Ganz T, Nemeth E. PMID: 16407589.
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    138. Regulation of iron metabolism by hepcidin. Annu Rev Nutr. 2006; 26:323-42. Nemeth E, Ganz T. PMID: 16848710.
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    139. Primary iron overload with inappropriate hepcidin expression in V162del ferroportin disease. Hepatology. 2005 Aug; 42(2):466-72. Zoller H, McFarlane I, Theurl I, Stadlmann S, Nemeth E, Oxley D, Ganz T, Halsall DJ, Cox TM, Vogel W. PMID: 15986403.
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    140. Novel urine hepcidin assay by mass spectrometry. Blood. 2005 Nov 01; 106(9):3268-70. Kemna E, Tjalsma H, Laarakkers C, Nemeth E, Willems H, Swinkels D. PMID: 16030189.
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    141. The molecular basis of ferroportin-linked hemochromatosis. Proc Natl Acad Sci U S A. 2005 Jun 21; 102(25):8955-60. De Domenico I, Ward DM, Nemeth E, Vaughn MB, Musci G, Ganz T, Kaplan J. PMID: 15956209.
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    142. Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs. Blood. 2005 Sep 15; 106(6):2196-9. Rivera S, Nemeth E, Gabayan V, Lopez MA, Farshidi D, Ganz T. PMID: 15933050.
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    143. Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS. Blood. 2005 Sep 01; 106(5):1864-6. Kemna E, Pickkers P, Nemeth E, van der Hoeven H, Swinkels D. PMID: 15886319.
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    144. Hepcidin levels in humans are correlated with hepatic iron stores, hemoglobin levels, and hepatic function. Blood. 2005 Jul 15; 106(2):746-8. Détivaud L, Nemeth E, Boudjema K, Turlin B, Troadec MB, Leroyer P, Ropert M, Jacquelinet S, Courselaud B, Ganz T, Brissot P, Loréal O. PMID: 15797999.
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    145. Hepcidin in iron overload disorders. Blood. 2005 May 15; 105(10):4103-5. Papanikolaou G, Tzilianos M, Christakis JI, Bogdanos D, Tsimirika K, MacFarlane J, Goldberg YP, Sakellaropoulos N, Ganz T, Nemeth E. PMID: 15671438.
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    146. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 2004 Dec 17; 306(5704):2090-3. Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, Ganz T, Kaplan J. PMID: 15514116.
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    147. Hepcidin is decreased in TFR2 hemochromatosis. Blood. 2005 Feb 15; 105(4):1803-6. Nemeth E, Roetto A, Garozzo G, Ganz T, Camaschella C. PMID: 15486069.
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    148. Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia. Blood. 2005 Feb 15; 105(4):1797-802. Rivera S, Liu L, Nemeth E, Gabayan V, Sorensen OE, Ganz T. PMID: 15479721.
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    149. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest. 2004 May; 113(9):1271-6. Nemeth E, Rivera S, Gabayan V, Keller C, Taudorf S, Pedersen BK, Ganz T. PMID: 15124018.
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    150. Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis. Nat Genet. 2004 Jan; 36(1):77-82. Papanikolaou G, Samuels ME, Ludwig EH, MacDonald ML, Franchini PL, Dubé MP, Andres L, MacFarlane J, Sakellaropoulos N, Politou M, Nemeth E, Thompson J, Risler JK, Zaborowska C, Babakaiff R, Radomski CC, Pape TD, Davidas O, Christakis J, Brissot P, Lockitch G, Ganz T, Hayden MR, Goldberg YP. PMID: 14647275.
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    151. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood. 2003 Apr 01; 101(7):2461-3. Nemeth E, Valore EV, Territo M, Schiller G, Lichtenstein A, Ganz T. PMID: 12433676.
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