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Listeria-Vectored Multiantigenic Tuberculosis Vaccine Enhances Protective Immunity against Aerosol Challenge with Virulent Mycobacterium tuberculosis in BCG-Immunized C57BL/6 and BALB/c Mice. mBio. 2022 Jun 01; e0068722.
Jia Q, Masleša-Galic S, Nava S, Horwitz MA. PMID: 35642945.
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Replicating bacterium-vectored vaccine expressing SARS-CoV-2 Membrane and Nucleocapsid proteins protects against severe COVID-19-like disease in hamsters. NPJ Vaccines. 2021 Mar 30; 6(1):47.
Jia Q, Bielefeldt-Ohmann H, Maison RM, Masleša-Galic S, Cooper SK, Bowen RA, Horwitz MA. PMID: 33785745; PMCID: PMC8009914.
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PubMed Mentions:
3
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Early innate and adaptive immune perturbations determine long-term severity of chronic virus and Mycobacterium tuberculosis coinfection. Immunity. 2021 03 09; 54(3):526-541.e7.
Xu W, Snell LM, Guo M, Boukhaled G, Macleod BL, Li M, Tullius MV, Guidos CJ, Tsao MS, Divangahi M, Horwitz MA, Liu J, Brooks DG. PMID: 33515487; PMCID: PMC7946746.
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PubMed Mentions:
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Replicating bacterium-vectored vaccine expressing SARS-CoV-2 Membrane and Nucleocapsid proteins protects against severe COVID-19 disease in hamsters. bioRxiv. 2020 Nov 18.
Jia Q, Bielefeldt-Ohmann H, Maison R, Masleša-Galic S, Bowen R, Horwitz MA. PMID: 33236013; PMCID: PMC7685323.
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PubMed Mentions:
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Atomic Structure of the Francisella T6SS Central Spike Reveals a Unique α-Helical Lid and a Putative Cargo. Structure. 2019 12 03; 27(12):1811-1819.e6.
Yang X, Clemens DL, Lee BY, Cui Y, Zhou ZH, Horwitz MA. PMID: 31677891; PMCID: PMC6939872.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Mutation of an L-Type Calcium Channel Gene Leads to T Lymphocyte Dysfunction. Front Immunol. 2019; 10:2473.
Fenninger F, Han J, Stanwood SR, Nohara LL, Arora H, Choi KB, Munro L, Pfeifer CG, Shanina I, Horwitz MS, Jefferies WA. PMID: 31736943; PMCID: PMC6833481.
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PubMed Mentions:
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Editorial: Fresh Ideas, Foundational Experiments: Immunology and Diabetes. Front Endocrinol (Lausanne). 2019; 10:315.
Spanier JA, Tse HM, Horwitz MS, Fife BT. PMID: 31156560; PMCID: PMC6532014.
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PubMed Mentions:
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Nanomachines and Other Caps on Mesoporous Silica Nanoparticles for Drug Delivery. Acc Chem Res. 2019 06 18; 52(6):1531-1542.
Chen W, Glackin CA, Horwitz MA, Zink JI. PMID: 31082188.
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PubMed Mentions:
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Artificial intelligence enabled parabolic response surface platform identifies ultra-rapid near-universal TB drug treatment regimens comprising approved drugs. PLoS One. 2019; 14(5):e0215607.
Clemens DL, Lee BY, Silva A, Dillon BJ, Masleša-Galic S, Nava S, Ding X, Ho CM, Horwitz MA. PMID: 31075149; PMCID: PMC6510528.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10. Cell. 2019 Apr 04; 177(2):492-493.
Rojas OL, Pröbstel AK, Porfilio EA, Wang AA, Charabati M, Sun T, Lee DSW, Galicia G, Ramaglia V, Ward LA, Leung LYT, Najafi G, Khaleghi K, Garcillán B, Li A, Besla R, Naouar I, Cao EY, Chiaranunt P, Burrows K, Robinson HG, Allanach JR, Yam J, Luck H, Campbell DJ, Allman D, Brooks DG, Tomura M, Baumann R, Zamvil SS, Bar-Or A, Horwitz MS, Winer DA, Mortha A, Mackay F, Prat A, Osborne LC, Robbins C, Baranzini SE, Gommerman JL. PMID: 30951673.
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PubMed Mentions:
14 Fields:
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Virus envelope tissue factor promotes infection in mice. J Thromb Haemost. 2019 03; 17(3):482-491.
Sutherland MR, Simon AY, Shanina I, Horwitz MS, Ruf W, Pryzdial ELG. PMID: 30659719; PMCID: PMC6397068.
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PubMed Mentions:
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PPE37 Is Essential for Mycobacterium tuberculosis Heme-Iron Acquisition (HIA), and a Defective PPE37 in Mycobacterium bovis BCG Prevents HIA. Infect Immun. 2019 02; 87(2).
Tullius MV, Nava S, Horwitz MA. PMID: 30455201; PMCID: PMC6346139.
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PubMed Mentions:
9 Fields:
Translation:
Cells
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Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10. Cell. 2019 01 24; 176(3):610-624.e18.
Rojas OL, Pröbstel AK, Porfilio EA, Wang AA, Charabati M, Sun T, Lee DSW, Galicia G, Ramaglia V, Ward LA, Leung LYT, Najafi G, Khaleghi K, Garcillán B, Li A, Besla R, Naouar I, Cao EY, Chiaranunt P, Burrows K, Robinson HG, Allanach JR, Yam J, Luck H, Campbell DJ, Allman D, Brooks DG, Tomura M, Baumann R, Zamvil SS, Bar-Or A, Horwitz MS, Winer DA, Mortha A, Mackay F, Prat A, Osborne LC, Robbins C, Baranzini SE, Gommerman JL. PMID: 30612739; PMCID: PMC6903689.
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PubMed Mentions:
54 Fields:
Translation:
HumansAnimalsCells
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Nanoparticle Formulation of Moxifloxacin and Intramuscular Route of Delivery Improve Antibiotic Pharmacokinetics and Treatment of Pneumonic Tularemia in a Mouse Model. ACS Infect Dis. 2019 02 08; 5(2):281-291.
Clemens DL, Lee BY, Plamthottam S, Tullius MV, Wang R, Yu CJ, Li Z, Dillon BJ, Zink JI, Horwitz MA. PMID: 30480992.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Ultra-rapid near universal TB drug regimen identified via parabolic response surface platform cures mice of both conventional and high susceptibility. PLoS One. 2018; 13(11):e0207469.
Lee BY, Clemens DL, Silva A, Dillon BJ, Masleša-Galic S, Nava S, Ho CM, Horwitz MA. PMID: 30427938; PMCID: PMC6235396.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Facile Strategy Enabling Both High Loading and High Release Amounts of the Water-Insoluble Drug Clofazimine Using Mesoporous Silica Nanoparticles. ACS Appl Mater Interfaces. 2018 Sep 26; 10(38):31870-31881.
Chen W, Cheng CA, Lee BY, Clemens DL, Huang WY, Horwitz MA, Zink JI. PMID: 30160469.
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PubMed Mentions:
13 Fields:
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Live Attenuated Tularemia Vaccines for Protection Against Respiratory Challenge With Virulent F. tularensis subsp. tularensis. Front Cell Infect Microbiol. 2018; 8:154.
Jia Q, Horwitz MA. PMID: 29868510; PMCID: PMC5963219.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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Single vector platform vaccine protects against lethal respiratory challenge with Tier 1 select agents of anthrax, plague, and tularemia. Sci Rep. 2018 05 03; 8(1):7009.
Jia Q, Bowen R, Dillon BJ, Masleša-Galic S, Chang BT, Kaidi AC, Horwitz MA. PMID: 29725025; PMCID: PMC5934503.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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The Francisella Type VI Secretion System. Front Cell Infect Microbiol. 2018; 8:121.
Clemens DL, Lee BY, Horwitz MA. PMID: 29740542; PMCID: PMC5924787.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Generation of a Dual-Target, Safe, Inexpensive Microbicide that Protects Against HIV-1 and HSV-2 Disease. Sci Rep. 2018 02 12; 8(1):2786.
Farr Zuend C, Nomellini JF, Smit J, Horwitz MS. PMID: 29434285; PMCID: PMC5809452.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Listeria-Vectored Vaccine Expressing the Mycobacterium tuberculosis 30-Kilodalton Major Secretory Protein via the Constitutively Active prfA* Regulon Boosts Mycobacterium bovis BCG Efficacy against Tuberculosis. Infect Immun. 2017 Sep; 85(9).
Jia Q, Dillon BJ, Masleša-Galic S, Horwitz MA. PMID: 28630063; PMCID: PMC5563566.
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PubMed Mentions:
7 Fields:
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A Pathogen-Specific Cargo Delivery Platform Based on Mesoporous Silica Nanoparticles. J Am Chem Soc. 2017 05 17; 139(19):6663-6668.
Ruehle B, Clemens DL, Lee BY, Horwitz MA, Zink JI. PMID: 28437093.
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PubMed Mentions:
10 Fields:
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Endogenous hepcidin and its agonist mediate resistance to selected infections by clearing non-transferrin-bound iron. Blood. 2017 07 20; 130(3):245-257.
Stefanova D, Raychev A, Arezes J, Ruchala P, Gabayan V, Skurnik M, Dillon BJ, Horwitz MA, Ganz T, Bulut Y, Nemeth E. PMID: 28465342; PMCID: PMC5520472.
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PubMed Mentions:
44 Fields:
Translation:
HumansAnimalsCells
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Drug regimens identified and optimized by output-driven platform markedly reduce tuberculosis treatment time. Nat Commun. 2017 01 24; 8:14183.
Lee BY, Clemens DL, Silva A, Dillon BJ, Masleša-Galic S, Nava S, Ding X, Ho CM, Horwitz MA. PMID: 28117835; PMCID: PMC5287291.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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Francisella tularensis Live Vaccine Strain deficient in capB and overexpressing the fusion protein of IglA, IglB, and IglC from the bfr promoter induces improved protection against F. tularensis respiratory challenge. Vaccine. 2016 09 22; 34(41):4969-4978.
Jia Q, Bowen R, Lee BY, Dillon BJ, Masleša-Galic S, Horwitz MA. PMID: 27577555; PMCID: PMC5028307.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Redox-Triggered Release of Moxifloxacin from Mesoporous Silica Nanoparticles Functionalized with Disulfide Snap-Tops Enhances Efficacy Against Pneumonic Tularemia in Mice. Small. 2016 Jul; 12(27):3690-702.
Lee BY, Li Z, Clemens DL, Dillon BJ, Hwang AA, Zink JI, Horwitz MA. PMID: 27246117.
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PubMed Mentions:
8 Fields:
Translation:
Animals
-
Output-driven feedback system control platform optimizes combinatorial therapy of tuberculosis using a macrophage cell culture model. Proc Natl Acad Sci U S A. 2016 Apr 12; 113(15):E2172-9.
Silva A, Lee BY, Clemens DL, Kee T, Ding X, Ho CM, Horwitz MA. PMID: 27035987; PMCID: PMC4839402.
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PubMed Mentions:
14 Fields:
Translation:
HumansCells
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Type I and Type II Interferon Coordinately Regulate Suppressive Dendritic Cell Fate and Function during Viral Persistence. PLoS Pathog. 2016 Jan; 12(1):e1005356.
Cunningham CR, Champhekar A, Tullius MV, Dillon BJ, Zhen A, de la Fuente JR, Herskovitz J, Elsaesser H, Snell LM, Wilson EB, de la Torre JC, Kitchen SG, Horwitz MA, Bensinger SJ, Smale ST, Brooks DG. PMID: 26808628; PMCID: PMC4726812.
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PubMed Mentions:
28 Fields:
Translation:
AnimalsCells
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Mesoporous Silica Nanoparticles with pH-Sensitive Nanovalves for Delivery of Moxifloxacin Provide Improved Treatment of Lethal Pneumonic Tularemia. ACS Nano. 2015 Nov 24; 9(11):10778-89.
Li Z, Clemens DL, Lee BY, Dillon BJ, Horwitz MA, Zink JI. PMID: 26435204.
View in:
PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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Tuberculosis: pH-Responsive Isoniazid-Loaded Nanoparticles Markedly Improve Tuberculosis Treatment in Mice (Small 38/2015). Small. 2015 Oct; 11(38):5065.
Hwang AA, Lee BY, Clemens DL, Dillon BJ, Zink JI, Horwitz MA. PMID: 26450161.
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PubMed Mentions:
1 Fields:
Translation:
Animals
-
pH-Responsive Isoniazid-Loaded Nanoparticles Markedly Improve Tuberculosis Treatment in Mice. Small. 2015 Oct; 11(38):5066-78.
Hwang AA, Lee BY, Clemens DL, Dillon BJ, Zink JI, Horwitz MA. PMID: 26193431; PMCID: PMC5628743.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Massively parallel delivery of large cargo into mammalian cells with light pulses. Nat Methods. 2015 May; 12(5):439-44.
Wu YC, Wu TH, Clemens DL, Lee BY, Wen X, Horwitz MA, Teitell MA, Chiou PY. PMID: 25849636; PMCID: PMC5082232.
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PubMed Mentions:
34 Fields:
Translation:
HumansAnimalsCells
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Atomic structure of T6SS reveals interlaced array essential to function. Cell. 2015 Feb 26; 160(5):940-951.
Clemens DL, Ge P, Lee BY, Horwitz MA, Zhou ZH. PMID: 25723168; PMCID: PMC4351867.
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PubMed Mentions:
76 Fields:
Translation:
Cells
-
Reduced expression of the MDA5 Gene IFIH1 prevents autoimmune diabetes. Diabetes. 2015 Jun; 64(6):2184-93.
Lincez PJ, Shanina I, Horwitz MS. PMID: 25591872.
View in:
PubMed Mentions:
34 Fields:
Translation:
Animals
-
rBCG30-induced immunity and cross-protection against Mycobacterium leprae challenge are enhanced by boosting with the Mycobacterium tuberculosis 30-kilodalton antigen 85B. Infect Immun. 2014 Sep; 82(9):3900-9.
Gillis TP, Tullius MV, Horwitz MA. PMID: 25001602; PMCID: PMC4187824.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCellsPHPublic Health
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Characterization of a Mycobacterium tuberculosis nanocompartment and its potential cargo proteins. J Biol Chem. 2014 Jun 27; 289(26):18279-89.
Contreras H, Joens MS, McMath LM, Le VP, Tullius MV, Kimmey JM, Bionghi N, Horwitz MA, Fitzpatrick JA, Goulding CW. PMID: 24855650; PMCID: PMC4140288.
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PubMed Mentions:
20 Fields:
Translation:
Cells
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Bacillus Calmette-Guerin vaccine-mediated neuroprotection is associated with regulatory T-cell induction in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. J Neurosci Res. 2013 Oct; 91(10):1292-302.
Lacan G, Dang H, Middleton B, Horwitz MA, Tian J, Melega WP, Kaufman DL. PMID: 23907992; PMCID: PMC5800426.
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PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
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A heterologous prime-boost vaccination strategy comprising the Francisella tularensis live vaccine strain capB mutant and recombinant attenuated Listeria monocytogenes expressing F. tularensis IglC induces potent protective immunity in mice against virulent F. tularensis aerosol challenge. Infect Immun. 2013 May; 81(5):1550-61.
Jia Q, Bowen R, Sahakian J, Dillon BJ, Horwitz MA. PMID: 23439306; PMCID: PMC3647989.
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PubMed Mentions:
17 Fields:
Translation:
AnimalsCellsPHPublic Health
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Gammaherpesvirus latency accentuates EAE pathogenesis: relevance to Epstein-Barr virus and multiple sclerosis. PLoS Pathog. 2012; 8(5):e1002715.
Casiraghi C, Shanina I, Cho S, Freeman ML, Blackman MA, Horwitz MS. PMID: 22615572; PMCID: PMC3355105.
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PubMed Mentions:
33 Fields:
Translation:
AnimalsCells
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Targeted intracellular delivery of antituberculosis drugs to Mycobacterium tuberculosis-infected macrophages via functionalized mesoporous silica nanoparticles. Antimicrob Agents Chemother. 2012 May; 56(5):2535-45.
Clemens DL, Lee BY, Xue M, Thomas CR, Meng H, Ferris D, Nel AE, Zink JI, Horwitz MA. PMID: 22354311; PMCID: PMC3346638.
View in:
PubMed Mentions:
39 Fields:
Translation:
HumansCells
-
Immunomodulation of antigen presenting cells promotes natural regulatory T cells that prevent autoimmune diabetes in NOD mice. PLoS One. 2012; 7(2):e31153.
Richer MJ, Lavallée DJ, Shanina I, Horwitz MS. PMID: 22355341; PMCID: PMC3280284.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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PSGL-1 regulates the migration and proliferation of CD8(+) T cells under homeostatic conditions. J Immunol. 2012 Feb 15; 188(4):1638-46.
Veerman KM, Carlow DA, Shanina I, Priatel JJ, Horwitz MS, Ziltener HJ. PMID: 22250093.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
-
O-antigen-deficient Francisella tularensis Live Vaccine Strain mutants are ingested via an aberrant form of looping phagocytosis and show altered kinetics of intracellular trafficking in human macrophages. Infect Immun. 2012 Mar; 80(3):952-67.
Clemens DL, Lee BY, Horwitz MA. PMID: 22202123; PMCID: PMC3294633.
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PubMed Mentions:
13 Fields:
Translation:
HumansCells
-
Enhanced neutralization of HIV by antibodies displayed on the S-layer of Caulobacter crescentus. Antimicrob Agents Chemother. 2011 Dec; 55(12):5547-52.
Duval M, Lewis CJ, Nomellini JF, Horwitz MS, Smit J, Cavacini LA. PMID: 21896905; PMCID: PMC3232825.
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PubMed Mentions:
7 Fields:
Translation:
HumansCells
-
Intravital imaging reveals limited antigen presentation and T cell effector function in mycobacterial granulomas. Immunity. 2011 May 27; 34(5):807-19.
Egen JG, Rothfuchs AG, Feng CG, Horwitz MA, Sher A, Germain RN. PMID: 21596592; PMCID: PMC3164316.
View in:
PubMed Mentions:
103 Fields:
Translation:
AnimalsCells
-
Discovery and characterization of a unique mycobacterial heme acquisition system. Proc Natl Acad Sci U S A. 2011 Mar 22; 108(12):5051-6.
Tullius MV, Harmston CA, Owens CP, Chim N, Morse RP, McMath LM, Iniguez A, Kimmey JM, Sawaya MR, Whitelegge JP, Horwitz MA, Goulding CW. PMID: 21383189; PMCID: PMC3064333.
View in:
PubMed Mentions:
94 Fields:
Translation:
Cells
-
A Francisella tularensis live vaccine strain (LVS) mutant with a deletion in capB, encoding a putative capsular biosynthesis protein, is significantly more attenuated than LVS yet induces potent protective immunity in mice against F. tularensis challenge. Infect Immun. 2010 Oct; 78(10):4341-55.
Jia Q, Lee BY, Bowen R, Dillon BJ, Som SM, Horwitz MA. PMID: 20643859; PMCID: PMC2950357.
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PubMed Mentions:
27 Fields:
Translation:
HumansAnimalsCells
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The Mycobacterium bovis bacille Calmette-Guerin phagosome proteome. Mol Cell Proteomics. 2010 Jan; 9(1):32-53.
Lee BY, Jethwaney D, Schilling B, Clemens DL, Gibson BW, Horwitz MA. PMID: 19815536; PMCID: PMC2808266.
View in:
PubMed Mentions:
28 Fields:
Translation:
HumansCells
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Preventing viral-induced type 1 diabetes. Ann N Y Acad Sci. 2009 Sep; 1173:487-92.
Richer MJ, Horwitz MS. PMID: 19758190.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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IL-6 during viral-induced chronic autoimmune myocarditis. Ann N Y Acad Sci. 2009 Sep; 1173:318-25.
Poffenberger MC, Horwitz MS. PMID: 19758168.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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Lack of IL-6 during coxsackievirus infection heightens the early immune response resulting in increased severity of chronic autoimmune myocarditis. PLoS One. 2009 Jul 09; 4(7):e6207.
Poffenberger MC, Straka N, El Warry N, Fang D, Shanina I, Horwitz MS. PMID: 19587788; PMCID: PMC2703827.
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PubMed Mentions:
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Novel recombinant BCG expressing perfringolysin O and the over-expression of key immunodominant antigens; pre-clinical characterization, safety and protection against challenge with Mycobacterium tuberculosis. Vaccine. 2009 Jul 16; 27(33):4412-23.
Sun R, Skeiky YA, Izzo A, Dheenadhayalan V, Imam Z, Penn E, Stagliano K, Haddock S, Mueller S, Fulkerson J, Scanga C, Grover A, Derrick SC, Morris S, Hone DM, Horwitz MA, Kaufmann SH, Sadoff JC. PMID: 19500523.
View in:
PubMed Mentions:
59 Fields:
Translation:
AnimalsCells
-
Francisella tularensis phagosomal escape does not require acidification of the phagosome. Infect Immun. 2009 May; 77(5):1757-73.
Clemens DL, Lee BY, Horwitz MA. PMID: 19237528; PMCID: PMC2681761.
View in:
PubMed Mentions:
39 Fields:
Translation:
HumansCells
-
Recombinant attenuated Listeria monocytogenes vaccine expressing Francisella tularensis IglC induces protection in mice against aerosolized Type A F. tularensis. Vaccine. 2009 Feb 18; 27(8):1216-29.
Jia Q, Lee BY, Clemens DL, Bowen RA, Horwitz MA. PMID: 19126421; PMCID: PMC2654553.
View in:
PubMed Mentions:
25 Fields:
Translation:
AnimalsCells
-
A new recombinant bacille Calmette-Guérin vaccine safely induces significantly enhanced tuberculosis-specific immunity in human volunteers. J Infect Dis. 2008 Nov 15; 198(10):1491-501.
Hoft DF, Blazevic A, Abate G, Hanekom WA, Kaplan G, Soler JH, Weichold F, Geiter L, Sadoff JC, Horwitz MA. PMID: 18808333; PMCID: PMC2670060.
View in:
PubMed Mentions:
60 Fields:
Translation:
HumansCellsCTClinical Trials
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Commonly administered BCG strains including an evolutionarily early strain and evolutionarily late strains of disparate genealogy induce comparable protective immunity against tuberculosis. Vaccine. 2009 Jan 14; 27(3):441-5.
Horwitz MA, Harth G, Dillon BJ, Maslesa-Galic S. PMID: 19007841; PMCID: PMC2657049.
View in:
PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
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A Replication-Limited Recombinant Mycobacterium bovis BCG vaccine against tuberculosis designed for human immunodeficiency virus-positive persons is safer and more efficacious than BCG. Infect Immun. 2008 Nov; 76(11):5200-14.
Tullius MV, Harth G, Maslesa-Galic S, Dillon BJ, Horwitz MA. PMID: 18725418; PMCID: PMC2573348.
View in:
PubMed Mentions:
31 Fields:
Translation:
HumansAnimalsCells
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The metabolic activity of Mycobacterium tuberculosis, assessed by use of a novel inducible GFP expression system, correlates with its capacity to inhibit phagosomal maturation and acidification in human macrophages. Mol Microbiol. 2008 May; 68(4):1047-60.
Lee BY, Clemens DL, Horwitz MA. PMID: 18363792; PMCID: PMC3591484.
View in:
PubMed Mentions:
14 Fields:
Translation:
HumansCells
-
Regulatory T-cells protect from type 1 diabetes after induction by coxsackievirus infection in the context of transforming growth factor-beta. Diabetes. 2008 May; 57(5):1302-11.
Richer MJ, Straka N, Fang D, Shanina I, Horwitz MS. PMID: 18268045.
View in:
PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
-
Chronic immunodeficiency in mice lacking RasGRP1 results in CD4 T cell immune activation and exhaustion. J Immunol. 2007 Aug 15; 179(4):2143-52.
Priatel JJ, Chen X, Zenewicz LA, Shen H, Harder KW, Horwitz MS, Teh HS. PMID: 17675473.
View in:
PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
-
Hairpin extensions enhance the efficacy of mycolyl transferase-specific antisense oligonucleotides targeting Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2007 Apr 24; 104(17):7199-204.
Harth G, Zamecnik PC, Tabatadze D, Pierson K, Horwitz MA. PMID: 17438292; PMCID: PMC1855390.
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PubMed Mentions:
11 Fields:
Translation:
HumansCells
-
Uptake and intracellular fate of Francisella tularensis in human macrophages. Ann N Y Acad Sci. 2007 Jun; 1105:160-86.
Clemens DL, Horwitz MA. PMID: 17435118.
View in:
PubMed Mentions:
54 Fields:
Translation:
HumansAnimalsCells
-
Desferri-Exochelin, a lipid-soluble, hexadentate iron chelator, effectively removes tissue iron. Transl Res. 2006 Aug; 148(2):63-71.
Hodges YK, Weinberger HD, Stephens J, Horwitz MA, Horwitz LD. PMID: 16890146.
View in:
PubMed Mentions:
2 Fields:
Translation:
Animals
-
Identification, recombinant expression, immunolocalization in macrophages, and T-cell responsiveness of the major extracellular proteins of Francisella tularensis. Infect Immun. 2006 Jul; 74(7):4002-13.
Lee BY, Horwitz MA, Clemens DL. PMID: 16790773; PMCID: PMC1489726.
View in:
PubMed Mentions:
38 Fields:
Translation:
AnimalsCells
-
All four Mycobacterium tuberculosis glnA genes encode glutamine synthetase activities but only GlnA1 is abundantly expressed and essential for bacterial homeostasis. Mol Microbiol. 2005 Nov; 58(4):1157-72.
Harth G, Maslesa-Galic S, Tullius MV, Horwitz MA. PMID: 16262797.
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PubMed Mentions:
36 Fields:
Translation:
Cells
-
A novel live recombinant mycobacterial vaccine against bovine tuberculosis more potent than BCG. Vaccine. 2006 Mar 06; 24(10):1593-600.
Horwitz MA, Harth G, Dillon BJ, Maslesa-Galic S. PMID: 16257099.
View in:
PubMed Mentions:
17 Fields:
Translation:
AnimalsPHPublic Health
-
Francisella tularensis enters macrophages via a novel process involving pseudopod loops. Infect Immun. 2005 Sep; 73(9):5892-902.
Clemens DL, Lee BY, Horwitz MA. PMID: 16113308; PMCID: PMC1231130.
View in:
PubMed Mentions:
99 Fields:
Translation:
HumansCells
-
Extraordinarily few organisms of a live recombinant BCG vaccine against tuberculosis induce maximal cell-mediated and protective immunity. Vaccine. 2006 Jan 23; 24(4):443-51.
Horwitz MA, Harth G, Dillon BJ, Maslesa-Galic S. PMID: 16125825.
View in:
PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
-
Enhancing the protective efficacy of Mycobacterium bovis BCG vaccination against tuberculosis by boosting with the Mycobacterium tuberculosis major secretory protein. Infect Immun. 2005 Aug; 73(8):4676-83.
Horwitz MA, Harth G, Dillon BJ, Maslesa-Galic S. PMID: 16040980; PMCID: PMC1201189.
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PubMed Mentions:
15 Fields:
Translation:
Animals
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Induction of antigen specific peripheral humoral tolerance to cardiac myosin does not prevent CB3-mediated autoimmune myocarditis. J Autoimmun. 2005 Sep; 25(2):102-11.
Horwitz MS, Ilic A, Fine C, Sarvetnick N. PMID: 16011890.
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Recombinant BCG expressing Mycobacterium tuberculosis major extracellular proteins. Microbes Infect. 2005 May; 7(5-6):947-54.
Horwitz MA. PMID: 15919223.
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12 Fields:
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HumansAnimalsCells
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A two-plasmid system for stable, selective-pressure-independent expression of multiple extracellular proteins in mycobacteria. Microbiology (Reading). 2004 Jul; 150(Pt 7):2143-2151.
Harth G, Masleša-Galic S, Horwitz MA. PMID: 15256557.
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5 Translation:
HumansAnimalsCells
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Virulent and avirulent strains of Francisella tularensis prevent acidification and maturation of their phagosomes and escape into the cytoplasm in human macrophages. Infect Immun. 2004 Jun; 72(6):3204-17.
Clemens DL, Lee BY, Horwitz MA. PMID: 15155622; PMCID: PMC415696.
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189 Fields:
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HumansCells
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Terminal deoxynucleotidyltransferase deficiency decreases autoimmune disease in diabetes-prone nonobese diabetic mice and lupus-prone MRL-Fas(lpr) mice. J Immunol. 2004 Apr 01; 172(7):4624-9.
Robey IF, Peterson M, Horwitz MS, Kono DH, Stratmann T, Theofilopoulos AN, Sarvetnick N, Teyton L, Feeney AJ. PMID: 15034081.
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12 Fields:
Translation:
AnimalsCells
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Glutamine synthetase GlnA1 is essential for growth of Mycobacterium tuberculosis in human THP-1 macrophages and guinea pigs. Infect Immun. 2003 Jul; 71(7):3927-36.
Tullius MV, Harth G, Horwitz MA. PMID: 12819079; PMCID: PMC162033.
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66 Fields:
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HumansAnimalsCells
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A new vaccine against tuberculosis affords greater survival after challenge than the current vaccine in the guinea pig model of pulmonary tuberculosis. Infect Immun. 2003 Apr; 71(4):1672-9.
Horwitz MA, Harth G. PMID: 12654780; PMCID: PMC152073.
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66 Fields:
Translation:
AnimalsCells
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Inhibition of Mycobacterium tuberculosis glutamine synthetase as a novel antibiotic strategy against tuberculosis: demonstration of efficacy in vivo. Infect Immun. 2003 Jan; 71(1):456-64.
Harth G, Horwitz MA. PMID: 12496196; PMCID: PMC143262.
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24 Fields:
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HumansAnimalsCells
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Targeting the Mycobacterium tuberculosis 30/32-kDa mycolyl transferase complex as a therapeutic strategy against tuberculosis: Proof of principle by using antisense technology. Proc Natl Acad Sci U S A. 2002 Nov 26; 99(24):15614-9.
Harth G, Horwitz MA, Tabatadze D, Zamecnik PC. PMID: 12427974; PMCID: PMC137765.
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20 Fields:
Translation:
Cells
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The Mycobacterium tuberculosis phagosome in human macrophages is isolated from the host cell cytoplasm. Infect Immun. 2002 Oct; 70(10):5800-7.
Clemens DL, Lee BY, Horwitz MA. PMID: 12228310; PMCID: PMC128330.
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PubMed Mentions:
12 Fields:
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HumansCells
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Bucillamine, a thiol antioxidant, prevents transplantation-associated reperfusion injury. Proc Natl Acad Sci U S A. 2002 Jun 25; 99(13):8915-20.
Amersi F, Nelson SK, Shen XD, Kato H, Melinek J, Kupiec-Weglinski JW, Horwitz LD, Busuttil RW, Horwitz MA. PMID: 12084933; PMCID: PMC124398.
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15 Fields:
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Animals
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Thiol antioxidants inhibit the adjuvant effects of aerosolized diesel exhaust particles in a murine model for ovalbumin sensitization. J Immunol. 2002 Mar 01; 168(5):2560-7.
Whitekus MJ, Li N, Zhang M, Wang M, Horwitz MA, Nelson SK, Horwitz LD, Brechun N, Diaz-Sanchez D, Nel AE. PMID: 11859152.
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48 Fields:
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AnimalsCells
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Primary demyelination in transgenic mice expressing interferon-gamma. Nat Med. 1997 Sep; 3(9):1037-1041.
Horwitz MS, Evans CF, Mcgavern DB, Rodriguez M, Oldstone MBA. PMID: 9288735; PMCID: PMC5321678.
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39 Fields:
Translation:
HumansAnimalsCells