Marcus Horwitz

Title(s)Professor, Medicine
SchoolMedicine
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    Title(s)Professor, MIMG


    Collapse Research 
    Collapse Research Activities and Funding
    Development of a novel TB vaccine safer and more effective than BCG based on a precisely controlled replication-limited Mycobacterium tuberculosis engineered for optimal in vivo growth and clearance
    NIH R01AI148122Mar 15, 2021 - Feb 28, 2026
    Role: Principal Investigator
    Composition, Atomic Structure and Function of the Francisella Type 6 Secretion System, a Distinct Subtype Essential for Phagosomal Escape, Intracellular Replication, and Virulence
    NIH R01AI151055Sep 21, 2020 - Aug 31, 2025
    Role: Principal Investigator
    Development of a Safe and Potent Vaccine Against Melioidosis using the LVS dcapB Vector Platform
    NIH R01AI141390Jun 1, 2019 - May 31, 2024
    Role: Principal Investigator
    Composition, structure, and mutational analysis of the Francisella Type VI Secretion System
    NIH R56AI125497Apr 10, 2018 - Mar 31, 2020
    Role: Principal Investigator
    Optimization and Advanced Proof-of-Concept Studies of a Listeria-vectored Multi-Antigenic Vaccine against Tuberculosis
    NIH R01AI135631Dec 1, 2017 - Nov 30, 2022
    Role: Principal Investigator
    Identification by High Throughput Screening of Inhibitors of Assembly and Secretion of the Francisella Type VI Secretion System
    NIH R21AI123630Feb 1, 2016 - Jan 31, 2019
    Role: Principal Investigator
    Pre-Exposure Prophylaxis Against Francisella tularensis
    NIH R01AI101189Jun 1, 2013 - May 31, 2018
    Role: Principal Investigator
    Pre-Exposure Prophylaxis Against Francisella tularensis
    NIH R56AI101189Aug 1, 2012 - May 31, 2013
    Role: Principal Investigator
    Development of a tularemia vaccine that is safer and more potent than LVS
    NIH R56AI084908Jul 6, 2010 - Jun 30, 2012
    Role: Principal Investigator
    A TB Vaccine for AIDS Patients
    NIH R01AI068413Jan 15, 2006 - Dec 31, 2011
    Role: Principal Investigator
    Novel Antimicrobial Agents Against M. tuberculosis
    NIH R01AI055352Jul 15, 2004 - Oct 31, 2009
    Role: Principal Investigator
    Characterization of the Francisella tularensis phagosome
    NIH R21AI053403Sep 15, 2002 - Aug 31, 2005
    Role: Principal Investigator
    M TUBERCULOSIS GLUTAMINE SYNTHETASE EXPORT &INHIBITION
    NIH R01AI042925Apr 1, 1998 - Mar 31, 2004
    Role: Principal Investigator
    Characterization of the M. tuberculosis phagosome
    NIH R01HL077000Sep 30, 1993 - Aug 31, 2009
    Role: Principal Investigator
    M TUBERCULOSIS PHAGOSOME
    NIH R01AI035275Sep 30, 1993 - Jun 30, 2004
    Role: Principal Investigator
    PROTECTIVE IMMUNITY AGAINST TUBERCULOSIS
    NIH R01AI035189Sep 30, 1993 - Jun 30, 1999
    Role: Principal Investigator
    EXOCHELINS, TUBERCULOSIS, AND AIDS
    NIH R01AI033790Jan 1, 1993 - Dec 31, 1996
    Role: Principal Investigator
    Development and Testing of New Tuberculosis Vaccines
    NIH R01AI031338Apr 1, 1991 - Feb 28, 2012
    Role: Principal Investigator
    IRON AND MONOCYTE ACTIVATION AGAINST A LUNG PATHOGEN
    NIH R01AI028825Feb 1, 1990 - Jan 31, 1996
    Role: Principal Investigator
    BIOLOGY OF MYCOBACTERIUM LEPRAE MONOCYTE INTERACTION
    NIH R01AI025143Jul 1, 1988 - Jun 30, 1992
    Role: Principal Investigator
    BIOLOGY OF MYCOBACTERIUM LEPRAE MONOCYTE INTERACTION
    NIH R22AI025143Jul 1, 1988 - Jun 30, 1991
    Role: Principal Investigator
    COMPLEMENT AND OPPORTUNISTIC MYCOBACTERIA IN AIDS
    NIH R01AI025681Sep 30, 1987 - Nov 30, 1991
    Role: Principal Investigator
    IMMUNE RESPONSE TO AN INTRACELLULAR PULMONARY PATHOGEN
    NIH R01AI022421Sep 1, 1985 - Jun 30, 1995
    Role: Principal Investigator
    TRANSMISSION ELECTRON MICROSCOPE AND MICROTOME
    NIH S10RR002334Jan 1, 1985 - Dec 31, 1985
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Listeria-Vectored Multiantigenic Tuberculosis Vaccine Enhances Protective Immunity against Aerosol Challenge with Virulent Mycobacterium tuberculosis in BCG-Immunized C57BL/6 and BALB/c Mice. mBio. 2022 Jun 01; e0068722. Jia Q, Masleša-Galic S, Nava S, Horwitz MA. PMID: 35642945.
      View in: PubMed   Mentions:
    2. Replicating bacterium-vectored vaccine expressing SARS-CoV-2 Membrane and Nucleocapsid proteins protects against severe COVID-19-like disease in hamsters. NPJ Vaccines. 2021 Mar 30; 6(1):47. Jia Q, Bielefeldt-Ohmann H, Maison RM, Masleša-Galic S, Cooper SK, Bowen RA, Horwitz MA. PMID: 33785745; PMCID: PMC8009914.
      View in: PubMed   Mentions: 3  
    3. Early innate and adaptive immune perturbations determine long-term severity of chronic virus and Mycobacterium tuberculosis coinfection. Immunity. 2021 03 09; 54(3):526-541.e7. Xu W, Snell LM, Guo M, Boukhaled G, Macleod BL, Li M, Tullius MV, Guidos CJ, Tsao MS, Divangahi M, Horwitz MA, Liu J, Brooks DG. PMID: 33515487; PMCID: PMC7946746.
      View in: PubMed   Mentions:
    4. Replicating bacterium-vectored vaccine expressing SARS-CoV-2 Membrane and Nucleocapsid proteins protects against severe COVID-19 disease in hamsters. bioRxiv. 2020 Nov 18. Jia Q, Bielefeldt-Ohmann H, Maison R, Masleša-Galic S, Bowen R, Horwitz MA. PMID: 33236013; PMCID: PMC7685323.
      View in: PubMed   Mentions:
    5. Atomic Structure of the Francisella T6SS Central Spike Reveals a Unique α-Helical Lid and a Putative Cargo. Structure. 2019 12 03; 27(12):1811-1819.e6. Yang X, Clemens DL, Lee BY, Cui Y, Zhou ZH, Horwitz MA. PMID: 31677891; PMCID: PMC6939872.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    6. Mutation of an L-Type Calcium Channel Gene Leads to T Lymphocyte Dysfunction. Front Immunol. 2019; 10:2473. Fenninger F, Han J, Stanwood SR, Nohara LL, Arora H, Choi KB, Munro L, Pfeifer CG, Shanina I, Horwitz MS, Jefferies WA. PMID: 31736943; PMCID: PMC6833481.
      View in: PubMed   Mentions:
    7. Editorial: Fresh Ideas, Foundational Experiments: Immunology and Diabetes. Front Endocrinol (Lausanne). 2019; 10:315. Spanier JA, Tse HM, Horwitz MS, Fife BT. PMID: 31156560; PMCID: PMC6532014.
      View in: PubMed   Mentions:
    8. Nanomachines and Other Caps on Mesoporous Silica Nanoparticles for Drug Delivery. Acc Chem Res. 2019 06 18; 52(6):1531-1542. Chen W, Glackin CA, Horwitz MA, Zink JI. PMID: 31082188.
      View in: PubMed   Mentions:
    9. Artificial intelligence enabled parabolic response surface platform identifies ultra-rapid near-universal TB drug treatment regimens comprising approved drugs. PLoS One. 2019; 14(5):e0215607. Clemens DL, Lee BY, Silva A, Dillon BJ, Masleša-Galic S, Nava S, Ding X, Ho CM, Horwitz MA. PMID: 31075149; PMCID: PMC6510528.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    10. Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10. Cell. 2019 Apr 04; 177(2):492-493. Rojas OL, Pröbstel AK, Porfilio EA, Wang AA, Charabati M, Sun T, Lee DSW, Galicia G, Ramaglia V, Ward LA, Leung LYT, Najafi G, Khaleghi K, Garcillán B, Li A, Besla R, Naouar I, Cao EY, Chiaranunt P, Burrows K, Robinson HG, Allanach JR, Yam J, Luck H, Campbell DJ, Allman D, Brooks DG, Tomura M, Baumann R, Zamvil SS, Bar-Or A, Horwitz MS, Winer DA, Mortha A, Mackay F, Prat A, Osborne LC, Robbins C, Baranzini SE, Gommerman JL. PMID: 30951673.
      View in: PubMed   Mentions: 14     Fields:    
    11. Virus envelope tissue factor promotes infection in mice. J Thromb Haemost. 2019 03; 17(3):482-491. Sutherland MR, Simon AY, Shanina I, Horwitz MS, Ruf W, Pryzdial ELG. PMID: 30659719; PMCID: PMC6397068.
      View in: PubMed   Mentions:
    12. PPE37 Is Essential for Mycobacterium tuberculosis Heme-Iron Acquisition (HIA), and a Defective PPE37 in Mycobacterium bovis BCG Prevents HIA. Infect Immun. 2019 02; 87(2). Tullius MV, Nava S, Horwitz MA. PMID: 30455201; PMCID: PMC6346139.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    13. Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10. Cell. 2019 01 24; 176(3):610-624.e18. Rojas OL, Pröbstel AK, Porfilio EA, Wang AA, Charabati M, Sun T, Lee DSW, Galicia G, Ramaglia V, Ward LA, Leung LYT, Najafi G, Khaleghi K, Garcillán B, Li A, Besla R, Naouar I, Cao EY, Chiaranunt P, Burrows K, Robinson HG, Allanach JR, Yam J, Luck H, Campbell DJ, Allman D, Brooks DG, Tomura M, Baumann R, Zamvil SS, Bar-Or A, Horwitz MS, Winer DA, Mortha A, Mackay F, Prat A, Osborne LC, Robbins C, Baranzini SE, Gommerman JL. PMID: 30612739; PMCID: PMC6903689.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    14. Nanoparticle Formulation of Moxifloxacin and Intramuscular Route of Delivery Improve Antibiotic Pharmacokinetics and Treatment of Pneumonic Tularemia in a Mouse Model. ACS Infect Dis. 2019 02 08; 5(2):281-291. Clemens DL, Lee BY, Plamthottam S, Tullius MV, Wang R, Yu CJ, Li Z, Dillon BJ, Zink JI, Horwitz MA. PMID: 30480992.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    15. Ultra-rapid near universal TB drug regimen identified via parabolic response surface platform cures mice of both conventional and high susceptibility. PLoS One. 2018; 13(11):e0207469. Lee BY, Clemens DL, Silva A, Dillon BJ, Masleša-Galic S, Nava S, Ho CM, Horwitz MA. PMID: 30427938; PMCID: PMC6235396.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    16. Facile Strategy Enabling Both High Loading and High Release Amounts of the Water-Insoluble Drug Clofazimine Using Mesoporous Silica Nanoparticles. ACS Appl Mater Interfaces. 2018 Sep 26; 10(38):31870-31881. Chen W, Cheng CA, Lee BY, Clemens DL, Huang WY, Horwitz MA, Zink JI. PMID: 30160469.
      View in: PubMed   Mentions: 13     Fields:    
    17. Live Attenuated Tularemia Vaccines for Protection Against Respiratory Challenge With Virulent F. tularensis subsp. tularensis. Front Cell Infect Microbiol. 2018; 8:154. Jia Q, Horwitz MA. PMID: 29868510; PMCID: PMC5963219.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    18. Single vector platform vaccine protects against lethal respiratory challenge with Tier 1 select agents of anthrax, plague, and tularemia. Sci Rep. 2018 05 03; 8(1):7009. Jia Q, Bowen R, Dillon BJ, Masleša-Galic S, Chang BT, Kaidi AC, Horwitz MA. PMID: 29725025; PMCID: PMC5934503.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    19. The Francisella Type VI Secretion System. Front Cell Infect Microbiol. 2018; 8:121. Clemens DL, Lee BY, Horwitz MA. PMID: 29740542; PMCID: PMC5924787.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    20. Generation of a Dual-Target, Safe, Inexpensive Microbicide that Protects Against HIV-1 and HSV-2 Disease. Sci Rep. 2018 02 12; 8(1):2786. Farr Zuend C, Nomellini JF, Smit J, Horwitz MS. PMID: 29434285; PMCID: PMC5809452.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    21. Listeria-Vectored Vaccine Expressing the Mycobacterium tuberculosis 30-Kilodalton Major Secretory Protein via the Constitutively Active prfA* Regulon Boosts Mycobacterium bovis BCG Efficacy against Tuberculosis. Infect Immun. 2017 Sep; 85(9). Jia Q, Dillon BJ, Masleša-Galic S, Horwitz MA. PMID: 28630063; PMCID: PMC5563566.
      View in: PubMed   Mentions: 7     Fields:    
    22. A Pathogen-Specific Cargo Delivery Platform Based on Mesoporous Silica Nanoparticles. J Am Chem Soc. 2017 05 17; 139(19):6663-6668. Ruehle B, Clemens DL, Lee BY, Horwitz MA, Zink JI. PMID: 28437093.
      View in: PubMed   Mentions: 10     Fields:    
    23. Endogenous hepcidin and its agonist mediate resistance to selected infections by clearing non-transferrin-bound iron. Blood. 2017 07 20; 130(3):245-257. Stefanova D, Raychev A, Arezes J, Ruchala P, Gabayan V, Skurnik M, Dillon BJ, Horwitz MA, Ganz T, Bulut Y, Nemeth E. PMID: 28465342; PMCID: PMC5520472.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    24. Drug regimens identified and optimized by output-driven platform markedly reduce tuberculosis treatment time. Nat Commun. 2017 01 24; 8:14183. Lee BY, Clemens DL, Silva A, Dillon BJ, Masleša-Galic S, Nava S, Ding X, Ho CM, Horwitz MA. PMID: 28117835; PMCID: PMC5287291.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    25. Francisella tularensis Live Vaccine Strain deficient in capB and overexpressing the fusion protein of IglA, IglB, and IglC from the bfr promoter induces improved protection against F. tularensis respiratory challenge. Vaccine. 2016 09 22; 34(41):4969-4978. Jia Q, Bowen R, Lee BY, Dillon BJ, Masleša-Galic S, Horwitz MA. PMID: 27577555; PMCID: PMC5028307.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    26. Redox-Triggered Release of Moxifloxacin from Mesoporous Silica Nanoparticles Functionalized with Disulfide Snap-Tops Enhances Efficacy Against Pneumonic Tularemia in Mice. Small. 2016 Jul; 12(27):3690-702. Lee BY, Li Z, Clemens DL, Dillon BJ, Hwang AA, Zink JI, Horwitz MA. PMID: 27246117.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    27. Output-driven feedback system control platform optimizes combinatorial therapy of tuberculosis using a macrophage cell culture model. Proc Natl Acad Sci U S A. 2016 Apr 12; 113(15):E2172-9. Silva A, Lee BY, Clemens DL, Kee T, Ding X, Ho CM, Horwitz MA. PMID: 27035987; PMCID: PMC4839402.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    28. Type I and Type II Interferon Coordinately Regulate Suppressive Dendritic Cell Fate and Function during Viral Persistence. PLoS Pathog. 2016 Jan; 12(1):e1005356. Cunningham CR, Champhekar A, Tullius MV, Dillon BJ, Zhen A, de la Fuente JR, Herskovitz J, Elsaesser H, Snell LM, Wilson EB, de la Torre JC, Kitchen SG, Horwitz MA, Bensinger SJ, Smale ST, Brooks DG. PMID: 26808628; PMCID: PMC4726812.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    29. Mesoporous Silica Nanoparticles with pH-Sensitive Nanovalves for Delivery of Moxifloxacin Provide Improved Treatment of Lethal Pneumonic Tularemia. ACS Nano. 2015 Nov 24; 9(11):10778-89. Li Z, Clemens DL, Lee BY, Dillon BJ, Horwitz MA, Zink JI. PMID: 26435204.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    30. Tuberculosis: pH-Responsive Isoniazid-Loaded Nanoparticles Markedly Improve Tuberculosis Treatment in Mice (Small 38/2015). Small. 2015 Oct; 11(38):5065. Hwang AA, Lee BY, Clemens DL, Dillon BJ, Zink JI, Horwitz MA. PMID: 26450161.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    31. pH-Responsive Isoniazid-Loaded Nanoparticles Markedly Improve Tuberculosis Treatment in Mice. Small. 2015 Oct; 11(38):5066-78. Hwang AA, Lee BY, Clemens DL, Dillon BJ, Zink JI, Horwitz MA. PMID: 26193431; PMCID: PMC5628743.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    32. Massively parallel delivery of large cargo into mammalian cells with light pulses. Nat Methods. 2015 May; 12(5):439-44. Wu YC, Wu TH, Clemens DL, Lee BY, Wen X, Horwitz MA, Teitell MA, Chiou PY. PMID: 25849636; PMCID: PMC5082232.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    33. Atomic structure of T6SS reveals interlaced array essential to function. Cell. 2015 Feb 26; 160(5):940-951. Clemens DL, Ge P, Lee BY, Horwitz MA, Zhou ZH. PMID: 25723168; PMCID: PMC4351867.
      View in: PubMed   Mentions: 76     Fields:    Translation:Cells
    34. Reduced expression of the MDA5 Gene IFIH1 prevents autoimmune diabetes. Diabetes. 2015 Jun; 64(6):2184-93. Lincez PJ, Shanina I, Horwitz MS. PMID: 25591872.
      View in: PubMed   Mentions: 34     Fields:    Translation:Animals
    35. rBCG30-induced immunity and cross-protection against Mycobacterium leprae challenge are enhanced by boosting with the Mycobacterium tuberculosis 30-kilodalton antigen 85B. Infect Immun. 2014 Sep; 82(9):3900-9. Gillis TP, Tullius MV, Horwitz MA. PMID: 25001602; PMCID: PMC4187824.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCellsPHPublic Health
    36. Characterization of a Mycobacterium tuberculosis nanocompartment and its potential cargo proteins. J Biol Chem. 2014 Jun 27; 289(26):18279-89. Contreras H, Joens MS, McMath LM, Le VP, Tullius MV, Kimmey JM, Bionghi N, Horwitz MA, Fitzpatrick JA, Goulding CW. PMID: 24855650; PMCID: PMC4140288.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    37. Bacillus Calmette-Guerin vaccine-mediated neuroprotection is associated with regulatory T-cell induction in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. J Neurosci Res. 2013 Oct; 91(10):1292-302. Lacan G, Dang H, Middleton B, Horwitz MA, Tian J, Melega WP, Kaufman DL. PMID: 23907992; PMCID: PMC5800426.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    38. A heterologous prime-boost vaccination strategy comprising the Francisella tularensis live vaccine strain capB mutant and recombinant attenuated Listeria monocytogenes expressing F. tularensis IglC induces potent protective immunity in mice against virulent F. tularensis aerosol challenge. Infect Immun. 2013 May; 81(5):1550-61. Jia Q, Bowen R, Sahakian J, Dillon BJ, Horwitz MA. PMID: 23439306; PMCID: PMC3647989.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCellsPHPublic Health
    39. Gammaherpesvirus latency accentuates EAE pathogenesis: relevance to Epstein-Barr virus and multiple sclerosis. PLoS Pathog. 2012; 8(5):e1002715. Casiraghi C, Shanina I, Cho S, Freeman ML, Blackman MA, Horwitz MS. PMID: 22615572; PMCID: PMC3355105.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    40. Targeted intracellular delivery of antituberculosis drugs to Mycobacterium tuberculosis-infected macrophages via functionalized mesoporous silica nanoparticles. Antimicrob Agents Chemother. 2012 May; 56(5):2535-45. Clemens DL, Lee BY, Xue M, Thomas CR, Meng H, Ferris D, Nel AE, Zink JI, Horwitz MA. PMID: 22354311; PMCID: PMC3346638.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    41. Immunomodulation of antigen presenting cells promotes natural regulatory T cells that prevent autoimmune diabetes in NOD mice. PLoS One. 2012; 7(2):e31153. Richer MJ, Lavallée DJ, Shanina I, Horwitz MS. PMID: 22355341; PMCID: PMC3280284.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    42. PSGL-1 regulates the migration and proliferation of CD8(+) T cells under homeostatic conditions. J Immunol. 2012 Feb 15; 188(4):1638-46. Veerman KM, Carlow DA, Shanina I, Priatel JJ, Horwitz MS, Ziltener HJ. PMID: 22250093.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    43. O-antigen-deficient Francisella tularensis Live Vaccine Strain mutants are ingested via an aberrant form of looping phagocytosis and show altered kinetics of intracellular trafficking in human macrophages. Infect Immun. 2012 Mar; 80(3):952-67. Clemens DL, Lee BY, Horwitz MA. PMID: 22202123; PMCID: PMC3294633.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    44. Enhanced neutralization of HIV by antibodies displayed on the S-layer of Caulobacter crescentus. Antimicrob Agents Chemother. 2011 Dec; 55(12):5547-52. Duval M, Lewis CJ, Nomellini JF, Horwitz MS, Smit J, Cavacini LA. PMID: 21896905; PMCID: PMC3232825.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    45. Intravital imaging reveals limited antigen presentation and T cell effector function in mycobacterial granulomas. Immunity. 2011 May 27; 34(5):807-19. Egen JG, Rothfuchs AG, Feng CG, Horwitz MA, Sher A, Germain RN. PMID: 21596592; PMCID: PMC3164316.
      View in: PubMed   Mentions: 103     Fields:    Translation:AnimalsCells
    46. Discovery and characterization of a unique mycobacterial heme acquisition system. Proc Natl Acad Sci U S A. 2011 Mar 22; 108(12):5051-6. Tullius MV, Harmston CA, Owens CP, Chim N, Morse RP, McMath LM, Iniguez A, Kimmey JM, Sawaya MR, Whitelegge JP, Horwitz MA, Goulding CW. PMID: 21383189; PMCID: PMC3064333.
      View in: PubMed   Mentions: 94     Fields:    Translation:Cells
    47. A Francisella tularensis live vaccine strain (LVS) mutant with a deletion in capB, encoding a putative capsular biosynthesis protein, is significantly more attenuated than LVS yet induces potent protective immunity in mice against F. tularensis challenge. Infect Immun. 2010 Oct; 78(10):4341-55. Jia Q, Lee BY, Bowen R, Dillon BJ, Som SM, Horwitz MA. PMID: 20643859; PMCID: PMC2950357.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    48. The Mycobacterium bovis bacille Calmette-Guerin phagosome proteome. Mol Cell Proteomics. 2010 Jan; 9(1):32-53. Lee BY, Jethwaney D, Schilling B, Clemens DL, Gibson BW, Horwitz MA. PMID: 19815536; PMCID: PMC2808266.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    49. Preventing viral-induced type 1 diabetes. Ann N Y Acad Sci. 2009 Sep; 1173:487-92. Richer MJ, Horwitz MS. PMID: 19758190.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    50. IL-6 during viral-induced chronic autoimmune myocarditis. Ann N Y Acad Sci. 2009 Sep; 1173:318-25. Poffenberger MC, Horwitz MS. PMID: 19758168.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    51. Lack of IL-6 during coxsackievirus infection heightens the early immune response resulting in increased severity of chronic autoimmune myocarditis. PLoS One. 2009 Jul 09; 4(7):e6207. Poffenberger MC, Straka N, El Warry N, Fang D, Shanina I, Horwitz MS. PMID: 19587788; PMCID: PMC2703827.
      View in: PubMed   Mentions:
    52. Novel recombinant BCG expressing perfringolysin O and the over-expression of key immunodominant antigens; pre-clinical characterization, safety and protection against challenge with Mycobacterium tuberculosis. Vaccine. 2009 Jul 16; 27(33):4412-23. Sun R, Skeiky YA, Izzo A, Dheenadhayalan V, Imam Z, Penn E, Stagliano K, Haddock S, Mueller S, Fulkerson J, Scanga C, Grover A, Derrick SC, Morris S, Hone DM, Horwitz MA, Kaufmann SH, Sadoff JC. PMID: 19500523.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    53. Francisella tularensis phagosomal escape does not require acidification of the phagosome. Infect Immun. 2009 May; 77(5):1757-73. Clemens DL, Lee BY, Horwitz MA. PMID: 19237528; PMCID: PMC2681761.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    54. Recombinant attenuated Listeria monocytogenes vaccine expressing Francisella tularensis IglC induces protection in mice against aerosolized Type A F. tularensis. Vaccine. 2009 Feb 18; 27(8):1216-29. Jia Q, Lee BY, Clemens DL, Bowen RA, Horwitz MA. PMID: 19126421; PMCID: PMC2654553.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    55. A new recombinant bacille Calmette-Guérin vaccine safely induces significantly enhanced tuberculosis-specific immunity in human volunteers. J Infect Dis. 2008 Nov 15; 198(10):1491-501. Hoft DF, Blazevic A, Abate G, Hanekom WA, Kaplan G, Soler JH, Weichold F, Geiter L, Sadoff JC, Horwitz MA. PMID: 18808333; PMCID: PMC2670060.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCellsCTClinical Trials
    56. Commonly administered BCG strains including an evolutionarily early strain and evolutionarily late strains of disparate genealogy induce comparable protective immunity against tuberculosis. Vaccine. 2009 Jan 14; 27(3):441-5. Horwitz MA, Harth G, Dillon BJ, Maslesa-Galic S. PMID: 19007841; PMCID: PMC2657049.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    57. A Replication-Limited Recombinant Mycobacterium bovis BCG vaccine against tuberculosis designed for human immunodeficiency virus-positive persons is safer and more efficacious than BCG. Infect Immun. 2008 Nov; 76(11):5200-14. Tullius MV, Harth G, Maslesa-Galic S, Dillon BJ, Horwitz MA. PMID: 18725418; PMCID: PMC2573348.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    58. The metabolic activity of Mycobacterium tuberculosis, assessed by use of a novel inducible GFP expression system, correlates with its capacity to inhibit phagosomal maturation and acidification in human macrophages. Mol Microbiol. 2008 May; 68(4):1047-60. Lee BY, Clemens DL, Horwitz MA. PMID: 18363792; PMCID: PMC3591484.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    59. Regulatory T-cells protect from type 1 diabetes after induction by coxsackievirus infection in the context of transforming growth factor-beta. Diabetes. 2008 May; 57(5):1302-11. Richer MJ, Straka N, Fang D, Shanina I, Horwitz MS. PMID: 18268045.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    60. Chronic immunodeficiency in mice lacking RasGRP1 results in CD4 T cell immune activation and exhaustion. J Immunol. 2007 Aug 15; 179(4):2143-52. Priatel JJ, Chen X, Zenewicz LA, Shen H, Harder KW, Horwitz MS, Teh HS. PMID: 17675473.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    61. Hairpin extensions enhance the efficacy of mycolyl transferase-specific antisense oligonucleotides targeting Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2007 Apr 24; 104(17):7199-204. Harth G, Zamecnik PC, Tabatadze D, Pierson K, Horwitz MA. PMID: 17438292; PMCID: PMC1855390.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    62. Uptake and intracellular fate of Francisella tularensis in human macrophages. Ann N Y Acad Sci. 2007 Jun; 1105:160-86. Clemens DL, Horwitz MA. PMID: 17435118.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    63. Desferri-Exochelin, a lipid-soluble, hexadentate iron chelator, effectively removes tissue iron. Transl Res. 2006 Aug; 148(2):63-71. Hodges YK, Weinberger HD, Stephens J, Horwitz MA, Horwitz LD. PMID: 16890146.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    64. Identification, recombinant expression, immunolocalization in macrophages, and T-cell responsiveness of the major extracellular proteins of Francisella tularensis. Infect Immun. 2006 Jul; 74(7):4002-13. Lee BY, Horwitz MA, Clemens DL. PMID: 16790773; PMCID: PMC1489726.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    65. All four Mycobacterium tuberculosis glnA genes encode glutamine synthetase activities but only GlnA1 is abundantly expressed and essential for bacterial homeostasis. Mol Microbiol. 2005 Nov; 58(4):1157-72. Harth G, Maslesa-Galic S, Tullius MV, Horwitz MA. PMID: 16262797.
      View in: PubMed   Mentions: 36     Fields:    Translation:Cells
    66. A novel live recombinant mycobacterial vaccine against bovine tuberculosis more potent than BCG. Vaccine. 2006 Mar 06; 24(10):1593-600. Horwitz MA, Harth G, Dillon BJ, Maslesa-Galic S. PMID: 16257099.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsPHPublic Health
    67. Francisella tularensis enters macrophages via a novel process involving pseudopod loops. Infect Immun. 2005 Sep; 73(9):5892-902. Clemens DL, Lee BY, Horwitz MA. PMID: 16113308; PMCID: PMC1231130.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansCells
    68. Extraordinarily few organisms of a live recombinant BCG vaccine against tuberculosis induce maximal cell-mediated and protective immunity. Vaccine. 2006 Jan 23; 24(4):443-51. Horwitz MA, Harth G, Dillon BJ, Maslesa-Galic S. PMID: 16125825.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    69. Enhancing the protective efficacy of Mycobacterium bovis BCG vaccination against tuberculosis by boosting with the Mycobacterium tuberculosis major secretory protein. Infect Immun. 2005 Aug; 73(8):4676-83. Horwitz MA, Harth G, Dillon BJ, Maslesa-Galic S. PMID: 16040980; PMCID: PMC1201189.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    70. Induction of antigen specific peripheral humoral tolerance to cardiac myosin does not prevent CB3-mediated autoimmune myocarditis. J Autoimmun. 2005 Sep; 25(2):102-11. Horwitz MS, Ilic A, Fine C, Sarvetnick N. PMID: 16011890.
      View in: PubMed   Mentions:
    71. Recombinant BCG expressing Mycobacterium tuberculosis major extracellular proteins. Microbes Infect. 2005 May; 7(5-6):947-54. Horwitz MA. PMID: 15919223.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    72. A two-plasmid system for stable, selective-pressure-independent expression of multiple extracellular proteins in mycobacteria. Microbiology (Reading). 2004 Jul; 150(Pt 7):2143-2151. Harth G, Masleša-Galic S, Horwitz MA. PMID: 15256557.
      View in: PubMed   Mentions: 5  Translation:HumansAnimalsCells
    73. Virulent and avirulent strains of Francisella tularensis prevent acidification and maturation of their phagosomes and escape into the cytoplasm in human macrophages. Infect Immun. 2004 Jun; 72(6):3204-17. Clemens DL, Lee BY, Horwitz MA. PMID: 15155622; PMCID: PMC415696.
      View in: PubMed   Mentions: 189     Fields:    Translation:HumansCells
    74. Terminal deoxynucleotidyltransferase deficiency decreases autoimmune disease in diabetes-prone nonobese diabetic mice and lupus-prone MRL-Fas(lpr) mice. J Immunol. 2004 Apr 01; 172(7):4624-9. Robey IF, Peterson M, Horwitz MS, Kono DH, Stratmann T, Theofilopoulos AN, Sarvetnick N, Teyton L, Feeney AJ. PMID: 15034081.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    75. Glutamine synthetase GlnA1 is essential for growth of Mycobacterium tuberculosis in human THP-1 macrophages and guinea pigs. Infect Immun. 2003 Jul; 71(7):3927-36. Tullius MV, Harth G, Horwitz MA. PMID: 12819079; PMCID: PMC162033.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    76. A new vaccine against tuberculosis affords greater survival after challenge than the current vaccine in the guinea pig model of pulmonary tuberculosis. Infect Immun. 2003 Apr; 71(4):1672-9. Horwitz MA, Harth G. PMID: 12654780; PMCID: PMC152073.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    77. Inhibition of Mycobacterium tuberculosis glutamine synthetase as a novel antibiotic strategy against tuberculosis: demonstration of efficacy in vivo. Infect Immun. 2003 Jan; 71(1):456-64. Harth G, Horwitz MA. PMID: 12496196; PMCID: PMC143262.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    78. Targeting the Mycobacterium tuberculosis 30/32-kDa mycolyl transferase complex as a therapeutic strategy against tuberculosis: Proof of principle by using antisense technology. Proc Natl Acad Sci U S A. 2002 Nov 26; 99(24):15614-9. Harth G, Horwitz MA, Tabatadze D, Zamecnik PC. PMID: 12427974; PMCID: PMC137765.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    79. The Mycobacterium tuberculosis phagosome in human macrophages is isolated from the host cell cytoplasm. Infect Immun. 2002 Oct; 70(10):5800-7. Clemens DL, Lee BY, Horwitz MA. PMID: 12228310; PMCID: PMC128330.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    80. Bucillamine, a thiol antioxidant, prevents transplantation-associated reperfusion injury. Proc Natl Acad Sci U S A. 2002 Jun 25; 99(13):8915-20. Amersi F, Nelson SK, Shen XD, Kato H, Melinek J, Kupiec-Weglinski JW, Horwitz LD, Busuttil RW, Horwitz MA. PMID: 12084933; PMCID: PMC124398.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    81. Thiol antioxidants inhibit the adjuvant effects of aerosolized diesel exhaust particles in a murine model for ovalbumin sensitization. J Immunol. 2002 Mar 01; 168(5):2560-7. Whitekus MJ, Li N, Zhang M, Wang M, Horwitz MA, Nelson SK, Horwitz LD, Brechun N, Diaz-Sanchez D, Nel AE. PMID: 11859152.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    82. Primary demyelination in transgenic mice expressing interferon-gamma. Nat Med. 1997 Sep; 3(9):1037-1041. Horwitz MS, Evans CF, Mcgavern DB, Rodriguez M, Oldstone MBA. PMID: 9288735; PMCID: PMC5321678.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
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