Daniel L Kaufman

Title(s)Professor, Molecular and Medical Pharmacology
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    Oral GABA treatment as a novel and safe therapy to ameliorate Sjögren?s syndrome
    NIH R21DE029020Jul 1, 2019 - Jun 30, 2021
    Role: Principal Investigator
    Repurposing lesogaberan for the treatment of type 1 diabetes
    NIH R21TR001742Sep 1, 2016 - Jul 31, 2019
    Role: Principal Investigator
    Combination immunotherapy to preserve beta-cell function in the context of autoimmunity
    NIH R21AI119831Jan 1, 2016 - Dec 31, 2018
    Role: Principal Investigator
    Reversal of T1D in NOD mice using a safe combination therapy
    NIH R01DK092480May 1, 2012 - Apr 30, 2016
    Role: Principal Investigator
    Multimodality imaging of beta-cell in anaimal models of T1DM and T2DM
    NIH R21DK080461Sep 30, 2008 - Jun 30, 2010
    Role: Principal Investigator
    Characterizing autoimmunity in NOD mouse islets, PLN and spleen
    NIH R21DK075070Sep 15, 2006 - Aug 31, 2009
    Role: Principal Investigator
    Characterizing MHCI's neuroactivity
    NIH R21NS053847Jan 1, 2006 - Dec 31, 2007
    Role: Principal Investigator
    A Neuroprotective Vaccine for Parkinson's Disease
    NIH R21NS049121Apr 15, 2005 - Mar 31, 2008
    Role: Principal Investigator
    Noninvasive PET Imaging of Islet Grafts
    NIH R21DK069839Sep 30, 2004 - Aug 31, 2007
    Role: Principal Investigator
    Noninvasive islet graft imaging by PET
    NIH R01DK068506Sep 1, 2004 - Feb 29, 2008
    Role: Principal Investigator
    MHCI Inhibition of Neuronal Repair Responses
    NIH R21NS047383Jul 1, 2004 - Apr 30, 2007
    Role: Principal Investigator
    Prevention of IDDM by Expression of a Modified I-Ag7
    NIH R21DK060211Sep 1, 2001 - Aug 31, 2003
    Role: Principal Investigator
    NIH R01DK058514Sep 30, 2000 - Sep 29, 2004
    Role: Principal Investigator
    NIH R21AI047773Sep 30, 1999 - Sep 29, 2001
    Role: Principal Investigator
    NIH R01DK048455Sep 30, 1994 - Aug 31, 2002
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Designing Personalized Antigen-Specific Immunotherapies for Autoimmune Diseases-The Case for Using Ignored Target Cell Antigen Determinants. Cells. 2022 03 23; 11(7). Tian J, Song M, Kaufman DL. PMID: 35406645; PMCID: PMC8997884.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    2. GABA Administration Ameliorates Sjogren's Syndrome in Two Different Mouse Models. Biomedicines. 2022 Jan 07; 10(1). Song M, Tian J, Middleton B, Nguyen CQ, Kaufman DL. PMID: 35052808; PMCID: PMC8773584.
      View in: PubMed   Mentions:
    3. GABA molecules made by B cells can dampen antitumour responses. Nature. 2021 11; 599(7885):374-376. Kaufman DL. PMID: 34732882.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    4. GABAA-Receptor Agonists Limit Pneumonitis and Death in Murine Coronavirus-Infected Mice. Viruses. 2021 05 23; 13(6). Tian J, Middleton B, Kaufman DL. PMID: 34071034; PMCID: PMC8224554.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    5. Homotaurine limits the spreading of T cell autoreactivity within the CNS and ameliorates disease in a model of multiple sclerosis. Sci Rep. 2021 03 08; 11(1):5402. Tian J, Song M, Kaufman DL. PMID: 33686135; PMCID: PMC7940650.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    6. GABAB-Receptor Agonist-Based Immunotherapy for Type 1 Diabetes in NOD Mice. Biomedicines. 2021 Jan 06; 9(1). Tian J, Middleton B, Lee VS, Park HW, Zhang Z, Kim B, Lowe C, Nguyen N, Liu H, Beyer RS, Chao HW, Chen R, Mai D, O'Laco KA, Song M, Kaufman DL. PMID: 33418884; PMCID: PMC7825043.
      View in: PubMed   Mentions: 3  
    7. GABA administration prevents severe illness and death following coronavirus infection in mice. bioRxiv. 2020 Oct 04. Tian J, Middleton B, Kaufman DL. PMID: 33024975; PMCID: PMC7536896.
      View in: PubMed   Mentions:
    8. Homotaurine Treatment Enhances CD4+ and CD8+ Regulatory T Cell Responses and Synergizes with Low-Dose Anti-CD3 to Enhance Diabetes Remission in Type 1 Diabetic Mice. Immunohorizons. 2019 10 21; 3(10):498-510. Tian J, Dang H, O'Laco KA, Song M, Tiu BC, Gilles S, Zakarian C, Kaufman DL. PMID: 31636084; PMCID: PMC6823932.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    9. Increased risk for T cell autoreactivity to ß-cell antigens in the mice expressing the Avy obesity-associated gene. Sci Rep. 2019 03 12; 9(1):4269. Yong J, Tian J, Dang H, Wu TT, Atkinson MA, Sun R, Kaufman DL. PMID: 30862859; PMCID: PMC6414670.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    10. A Clinically Applicable Positive Allosteric Modulator of GABA Receptors Promotes Human β-Cell Replication and Survival as well as GABA's Ability to Inhibit Inflammatory T Cells. J Diabetes Res. 2019; 2019:5783545. Tian J, Dang H, Karashchuk N, Xu I, Kaufman DL. PMID: 30937314; PMCID: PMC6413367.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    11. Homotaurine, a safe blood-brain barrier permeable GABAA-R-specific agonist, ameliorates disease in mouse models of multiple sclerosis. Sci Rep. 2018 11 08; 8(1):16555. Tian J, Dang H, Wallner M, Olsen R, Kaufman DL. PMID: 30410049; PMCID: PMC6224391.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    12. A randomized controlled trial comparing efficacy of early video capsule endoscopy with standard of care in the approach to nonhematemesis GI bleeding (with videos). Gastrointest Endosc. 2019 01; 89(1):33-43.e4. Marya NB, Jawaid S, Foley A, Han S, Patel K, Maranda L, Kaufman D, Bhattacharya K, Marshall C, Tennyson J, Cave DR. PMID: 29935143; PMCID: PMC6501558.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    13. Repurposing Lesogaberan to Promote Human Islet Cell Survival and β-Cell Replication. J Diabetes Res. 2017; 2017:6403539. Tian J, Dang H, Hu A, Xu W, Kaufman DL. PMID: 29018828; PMCID: PMC5605788.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    14. Small Intestinal Angioectasia: Characterization, Risk Factors, and Rebleeding. J Clin Gastroenterol. 2017 Sep; 51(8):720-727. Kaufman D, Leslie G, Marya N, Han S, Gillespie W, Holzwanger E, Leslie R, Cave D. PMID: 27557115.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    15. Clinically applicable GABA receptor positive allosteric modulators promote ß-cell replication. Sci Rep. 2017 03 23; 7(1):374. Tian J, Dang H, Middleton B, Kaufman DL. PMID: 28336918; PMCID: PMC5428733.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    16. Combined therapy with GABA and proinsulin/alum acts synergistically to restore long-term normoglycemia by modulating T-cell autoimmunity and promoting β-cell replication in newly diabetic NOD mice. Diabetes. 2014 Sep; 63(9):3128-34. Tian J, Dang H, Nguyen AV, Chen Z, Kaufman DL. PMID: 25146474; PMCID: PMC4141368.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    17. γ-Aminobutyric acid regulates both the survival and replication of human β-cells. Diabetes. 2013 Nov; 62(11):3760-5. Tian J, Dang H, Chen Z, Guan A, Jin Y, Atkinson MA, Kaufman DL. PMID: 23995958; PMCID: PMC3806626.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    18. Bacillus Calmette-Guerin vaccine-mediated neuroprotection is associated with regulatory T-cell induction in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. J Neurosci Res. 2013 Oct; 91(10):1292-302. Lacan G, Dang H, Middleton B, Horwitz MA, Tian J, Melega WP, Kaufman DL. PMID: 23907992; PMCID: PMC5800426.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    19. Major histocompatibility complex class I molecules modulate embryonic neuritogenesis and neuronal polarization. J Neuroimmunol. 2012 Jun 15; 247(1-2):1-8. Bilousova T, Dang H, Xu W, Gustafson S, Jin Y, Wickramasinghe L, Won T, Bobarnac G, Middleton B, Tian J, Kaufman DL. PMID: 22503373; PMCID: PMC5776040.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    20. Combining antigen-based therapy with GABA treatment synergistically prolongs survival of transplanted ß-cells in diabetic NOD mice. PLoS One. 2011; 6(9):e25337. Tian J, Dang H, Kaufman DL. PMID: 21966502; PMCID: PMC3178649.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    21. Oral treatment with γ-aminobutyric acid improves glucose tolerance and insulin sensitivity by inhibiting inflammation in high fat diet-fed mice. PLoS One. 2011; 6(9):e25338. Tian J, Dang HN, Yong J, Chui WS, Dizon MP, Yaw CK, Kaufman DL. PMID: 21966503; PMCID: PMC3178643.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    22. Oral GABA treatment downregulates inflammatory responses in a mouse model of rheumatoid arthritis. Autoimmunity. 2011 Sep; 44(6):465-70. Tian J, Yong J, Dang H, Kaufman DL. PMID: 21604972; PMCID: PMC5787624.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    23. A potential role for shed soluble major histocompatibility class I molecules as modulators of neurite outgrowth. PLoS One. 2011 Mar 31; 6(3):e18439. Washburn LR, Zekzer D, Eitan S, Lu Y, Dang H, Middleton B, Evans CJ, Tian J, Kaufman DL. PMID: 21483793; PMCID: PMC3069096.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    24. Multimodality imaging of β-cells in mouse models of type 1 and 2 diabetes. Diabetes. 2011 May; 60(5):1383-92. Yong J, Rasooly J, Dang H, Lu Y, Middleton B, Zhang Z, Hon L, Namavari M, Stout DB, Atkinson MA, Tian J, Gambhir SS, Kaufman DL. PMID: 21441442; PMCID: PMC3292311.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    25. BCG vaccine-induced neuroprotection in a mouse model of Parkinson's disease. PLoS One. 2011 Jan 31; 6(1):e16610. Yong J, Lacan G, Dang H, Hsieh T, Middleton B, Wasserfall C, Tian J, Melega WP, Kaufman DL. PMID: 21304945; PMCID: PMC3031604.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsPHPublic Health
    26. Transgenic mice with enhanced neuronal major histocompatibility complex class I expression recover locomotor function better after spinal cord injury. J Neurosci Res. 2011 Mar; 89(3):365-72. Joseph MS, Bilousova T, Zdunowski S, Wu ZP, Middleton B, Boudzinskaia M, Wong B, Ali N, Zhong H, Yong J, Washburn L, Escande-Beillard N, Dang H, Edgerton VR, Tillakaratne NJ, Kaufman DL. PMID: 21259323; PMCID: PMC3087178.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    27. Major histocompatibility complex class I-mediated inhibition of neurite outgrowth from peripheral nerves. Immunol Lett. 2011 Mar 30; 135(1-2):118-23. Wu ZP, Bilousova T, Escande-Beillard N, Dang H, Hsieh T, Tian J, Kaufman DL. PMID: 20974178; PMCID: PMC5776043.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    28. Enhanced neuronal expression of major histocompatibility complex class I leads to aberrations in neurodevelopment and neurorepair. J Neuroimmunol. 2011 Mar; 232(1-2):8-16. Wu ZP, Washburn L, Bilousova TV, Boudzinskaia M, Escande-Beillard N, Querubin J, Dang H, Xie CW, Tian J, Kaufman DL. PMID: 20950866; PMCID: PMC5776042.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    29. Neurons preferentially respond to self-MHC class I allele products regardless of peptide presented. J Immunol. 2010 Jan 15; 184(2):816-23. Escande-Beillard N, Washburn L, Zekzer D, Wu ZP, Eitan S, Ivkovic S, Lu Y, Dang H, Middleton B, Bilousova TV, Yoshimura Y, Evans CJ, Joyce S, Tian J, Kaufman DL. PMID: 20018625; PMCID: PMC2997386.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    30. Transgenically induced GAD tolerance curtails the development of early beta-cell autoreactivities but causes the subsequent development of supernormal autoreactivities to other beta-cell antigens. Diabetes. 2009 Dec; 58(12):2843-50. Tian J, Dang H, von Boehmer H, Jaeckel E, Kaufman DL. PMID: 19741165; PMCID: PMC2780885.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    31. Antigen-based therapy for the treatment of type 1 diabetes. Diabetes. 2009 Sep; 58(9):1939-46. Tian J, Kaufman DL. PMID: 19720821; PMCID: PMC2731536.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    32. Design, synthesis, and antihepatocellular carcinoma activity of nitric oxide releasing derivatives of oleanolic acid. J Med Chem. 2008 Aug 14; 51(15):4834-8. Chen L, Zhang Y, Kong X, Lan E, Huang Z, Peng S, Kaufman DL, Tian J. PMID: 18598019; PMCID: PMC7713708.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    33. Early-life stress and the development of obesity and insulin resistance in juvenile bonnet macaques. Diabetes. 2007 May; 56(5):1382-6. Kaufman D, Banerji MA, Shorman I, Smith EL, Coplan JD, Rosenblum LA, Kral JG. PMID: 17470564.
      View in: PubMed   Mentions: 55     Fields:    Translation:Animals
    34. Long-term monitoring of transplanted islets using positron emission tomography. Mol Ther. 2006 Dec; 14(6):851-6. Lu Y, Dang H, Middleton B, Campbell-Thompson M, Atkinson MA, Gambhir SS, Tian J, Kaufman DL. PMID: 16982215.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    35. Noninvasive imaging of islet grafts using positron-emission tomography. Proc Natl Acad Sci U S A. 2006 Jul 25; 103(30):11294-9. Lu Y, Dang H, Middleton B, Zhang Z, Washburn L, Stout DB, Campbell-Thompson M, Atkinson MA, Phelps M, Gambhir SS, Tian J, Kaufman DL. PMID: 16868090; PMCID: PMC1544080.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    36. B cells are crucial for determinant spreading of T cell autoimmunity among beta cell antigens in diabetes-prone nonobese diabetic mice. J Immunol. 2006 Feb 15; 176(4):2654-61. Tian J, Zekzer D, Lu Y, Dang H, Kaufman DL. PMID: 16456028.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCellsPHPublic Health
    37. Antigen-based therapies using ignored determinants of beta cell antigens can more effectively inhibit late-stage autoimmune disease in diabetes-prone mice. J Immunol. 2005 Aug 01; 175(3):1991-9. Olcott AP, Tian J, Walker V, Dang H, Middleton B, Adorini L, Washburn L, Kaufman DL. PMID: 16034144.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    38. Gamma-aminobutyric acid inhibits T cell autoimmunity and the development of inflammatory responses in a mouse type 1 diabetes model. J Immunol. 2004 Oct 15; 173(8):5298-304. Tian J, Lu Y, Zhang H, Chau CH, Dang HN, Kaufman DL. PMID: 15470076.
      View in: PubMed   Mentions: 90     Fields:    Translation:AnimalsCells
    39. A salen-manganese catalytic free radical scavenger inhibits type 1 diabetes and islet allograft rejection. Diabetes. 2004 Oct; 53(10):2574-80. Olcott AP, Tocco G, Tian J, Zekzer D, Fukuto J, Ignarro L, Kaufman DL. PMID: 15448086.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    40. Bioluminescent monitoring of islet graft survival after transplantation. Mol Ther. 2004 Mar; 9(3):428-35. Lu Y, Dang H, Middleton B, Zhang Z, Washburn L, Campbell-Thompson M, Atkinson MA, Gambhir SS, Tian J, Kaufman DL. PMID: 15006610.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    41. Memory and effector T cells modulate subsequently primed immune responses to unrelated antigens. Cell Immunol. 2003 Aug; 224(2):74-85. Tian J, Lu Y, Hanssen L, Dang H, Kaufman DL. PMID: 14609573.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    42. Murder mysteries in type 1 diabetes. Nat Med. 2003 Feb; 9(2):161-2. Kaufman DL. PMID: 12563331.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    43. Antigen-based immunotherapy drives the precocious development of autoimmunity. J Immunol. 2002 Dec 01; 169(11):6564-9. Tian J, Olcott AP, Kaufman DL. PMID: 12444168.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    44. Report from the 1st International NOD Mouse T-Cell Workshop and the follow-up mini-workshop. Diabetes. 2001 Nov; 50(11):2459-63. Kaufman DL, Tisch R, Sarvetnick N, Chatenoud L, Harrison LC, Haskins K, Quinn A, Sercarz E, Singh B, von Herrath M, Wegmann D, Wen L, Zekzer D. PMID: 11679422.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
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