Daniel L Kaufman

Title(s)Professor, Molecular and Medical Pharmacology
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    Immunotherapeutics for disease

    Research in our lab is focused on 1) understanding the basis for immune-mediated disorders and 2) developing new therapeutics in preclinical models to help alleviate these disorders. A diagnostic test and two therapeutics for type 1 diabetes that our lab helped to develop are now in clinical use or are being tested in clinical trials. Second, we have demonstrated that immune cells express receptors for the neurotransmitter GABA and that the activation of these receptors can safely inhibit their inflammatory activities. Based on their anti-inflammatory actions, we have shown that the administration of GABA receptor agonists can inhibit or reverse type 1 diabetes, rheumatoid arthritis, and multiple sclerosis in mouse models. During the COVID-19 pandemic, we pivoted our work to study whether GABA treatment could be repurposed to help treat the excessive immune responses that cause severe illness in COVID-19 patients. We showed that GABA treatment effectively prevents severe disease and death in two different mouse models of COVID-19. Most recently, we have embarked on studies on 1) how GABA released from glioblastomas may inhibit local anti-tumor responses and 2) developing new therapeutics to limit neuroinflammation following SARS-CoV-2 infection that is associated with long COVID.
    Our future research will continue to develop ways to help modulate the immune system to ameliorate human diseases.
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    Oral GABA treatment as a novel and safe therapy to ameliorate Sjögren?s syndrome
    NIH R21DE029020Jul 1, 2019 - Jun 30, 2021
    Role: Principal Investigator
    Repurposing lesogaberan for the treatment of type 1 diabetes
    NIH R21TR001742Sep 1, 2016 - Jul 31, 2019
    Role: Principal Investigator
    Combination immunotherapy to preserve beta-cell function in the context of autoimmunity
    NIH R21AI119831Jan 1, 2016 - Dec 31, 2018
    Role: Principal Investigator
    Reversal of T1D in NOD mice using a safe combination therapy
    NIH R01DK092480May 1, 2012 - Apr 30, 2016
    Role: Principal Investigator
    Multimodality imaging of beta-cell in anaimal models of T1DM and T2DM
    NIH R21DK080461Sep 30, 2008 - Jun 30, 2010
    Role: Principal Investigator
    Characterizing autoimmunity in NOD mouse islets, PLN and spleen
    NIH R21DK075070Sep 15, 2006 - Aug 31, 2009
    Role: Principal Investigator
    Characterizing MHCI's neuroactivity
    NIH R21NS053847Jan 1, 2006 - Dec 31, 2007
    Role: Principal Investigator
    A Neuroprotective Vaccine for Parkinson's Disease
    NIH R21NS049121Apr 15, 2005 - Mar 31, 2008
    Role: Principal Investigator
    Noninvasive PET Imaging of Islet Grafts
    NIH R21DK069839Sep 30, 2004 - Aug 31, 2007
    Role: Principal Investigator
    Noninvasive islet graft imaging by PET
    NIH R01DK068506Sep 1, 2004 - Feb 29, 2008
    Role: Principal Investigator
    MHCI Inhibition of Neuronal Repair Responses
    NIH R21NS047383Jul 1, 2004 - Apr 30, 2007
    Role: Principal Investigator
    Prevention of IDDM by Expression of a Modified I-Ag7
    NIH R21DK060211Sep 1, 2001 - Aug 31, 2003
    Role: Principal Investigator
    NIH R01DK058514Sep 30, 2000 - Sep 29, 2004
    Role: Principal Investigator
    NIH R21AI047773Sep 30, 1999 - Sep 29, 2001
    Role: Principal Investigator
    NIH R01DK048455Sep 30, 1994 - Aug 31, 2002
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The GABA and GABA-Receptor System in Inflammation, Anti-Tumor Immune Responses, and COVID-19. Biomedicines. 2023 Jan 18; 11(2). Tian J, Kaufman DL. PMID: 36830790; PMCID: PMC9953446.
      View in: PubMed   Mentions: 5  
    2. A GABA-receptor agonist reduces pneumonitis severity, viral load, and death rate in SARS-CoV-2-infected mice. Front Immunol. 2022; 13:1007955. Tian J, Dillion BJ, Henley J, Comai L, Kaufman DL. PMID: 36389819; PMCID: PMC9640739.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    3. Designing Personalized Antigen-Specific Immunotherapies for Autoimmune Diseases-The Case for Using Ignored Target Cell Antigen Determinants. Cells. 2022 03 23; 11(7). Tian J, Song M, Kaufman DL. PMID: 35406645; PMCID: PMC8997884.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    4. GABA Administration Ameliorates Sjogren's Syndrome in Two Different Mouse Models. Biomedicines. 2022 Jan 07; 10(1). Song M, Tian J, Middleton B, Nguyen CQ, Kaufman DL. PMID: 35052808; PMCID: PMC8773584.
      View in: PubMed   Mentions: 3  
    5. GABA molecules made by B cells can dampen antitumour responses. Nature. 2021 11; 599(7885):374-376. Kaufman DL. PMID: 34732882.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    6. GABAA-Receptor Agonists Limit Pneumonitis and Death in Murine Coronavirus-Infected Mice. Viruses. 2021 05 23; 13(6). Tian J, Middleton B, Kaufman DL. PMID: 34071034; PMCID: PMC8224554.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    7. Homotaurine limits the spreading of T cell autoreactivity within the CNS and ameliorates disease in a model of multiple sclerosis. Sci Rep. 2021 03 08; 11(1):5402. Tian J, Song M, Kaufman DL. PMID: 33686135; PMCID: PMC7940650.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    8. GABAB-Receptor Agonist-Based Immunotherapy for Type 1 Diabetes in NOD Mice. Biomedicines. 2021 Jan 06; 9(1). Tian J, Middleton B, Lee VS, Park HW, Zhang Z, Kim B, Lowe C, Nguyen N, Liu H, Beyer RS, Chao HW, Chen R, Mai D, O'Laco KA, Song M, Kaufman DL. PMID: 33418884; PMCID: PMC7825043.
      View in: PubMed   Mentions: 6  
    9. GABA administration prevents severe illness and death following coronavirus infection in mice. bioRxiv. 2020 Oct 04. Tian J, Middleton B, Kaufman DL. PMID: 33024975; PMCID: PMC7536896.
      View in: PubMed   Mentions: 1  
    10. Homotaurine Treatment Enhances CD4+ and CD8+ Regulatory T Cell Responses and Synergizes with Low-Dose Anti-CD3 to Enhance Diabetes Remission in Type 1 Diabetic Mice. Immunohorizons. 2019 10 21; 3(10):498-510. Tian J, Dang H, O'Laco KA, Song M, Tiu BC, Gilles S, Zakarian C, Kaufman DL. PMID: 31636084; PMCID: PMC6823932.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    11. Increased risk for T cell autoreactivity to ß-cell antigens in the mice expressing the Avy obesity-associated gene. Sci Rep. 2019 03 12; 9(1):4269. Yong J, Tian J, Dang H, Wu TT, Atkinson MA, Sun R, Kaufman DL. PMID: 30862859; PMCID: PMC6414670.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    12. A Clinically Applicable Positive Allosteric Modulator of GABA Receptors Promotes Human β-Cell Replication and Survival as well as GABA's Ability to Inhibit Inflammatory T Cells. J Diabetes Res. 2019; 2019:5783545. Tian J, Dang H, Karashchuk N, Xu I, Kaufman DL. PMID: 30937314; PMCID: PMC6413367.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    13. Homotaurine, a safe blood-brain barrier permeable GABAA-R-specific agonist, ameliorates disease in mouse models of multiple sclerosis. Sci Rep. 2018 11 08; 8(1):16555. Tian J, Dang H, Wallner M, Olsen R, Kaufman DL. PMID: 30410049; PMCID: PMC6224391.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    14. A randomized controlled trial comparing efficacy of early video capsule endoscopy with standard of care in the approach to nonhematemesis GI bleeding (with videos). Gastrointest Endosc. 2019 01; 89(1):33-43.e4. Marya NB, Jawaid S, Foley A, Han S, Patel K, Maranda L, Kaufman D, Bhattacharya K, Marshall C, Tennyson J, Cave DR. PMID: 29935143; PMCID: PMC6501558.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    15. Repurposing Lesogaberan to Promote Human Islet Cell Survival and β-Cell Replication. J Diabetes Res. 2017; 2017:6403539. Tian J, Dang H, Hu A, Xu W, Kaufman DL. PMID: 29018828; PMCID: PMC5605788.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    16. Clinically applicable GABA receptor positive allosteric modulators promote ß-cell replication. Sci Rep. 2017 03 23; 7(1):374. Tian J, Dang H, Middleton B, Kaufman DL. PMID: 28336918; PMCID: PMC5428733.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    17. Combined therapy with GABA and proinsulin/alum acts synergistically to restore long-term normoglycemia by modulating T-cell autoimmunity and promoting β-cell replication in newly diabetic NOD mice. Diabetes. 2014 Sep; 63(9):3128-34. Tian J, Dang H, Nguyen AV, Chen Z, Kaufman DL. PMID: 25146474; PMCID: PMC4141368.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    18. γ-Aminobutyric acid regulates both the survival and replication of human β-cells. Diabetes. 2013 Nov; 62(11):3760-5. Tian J, Dang H, Chen Z, Guan A, Jin Y, Atkinson MA, Kaufman DL. PMID: 23995958; PMCID: PMC3806626.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    19. Bacillus Calmette-Guerin vaccine-mediated neuroprotection is associated with regulatory T-cell induction in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. J Neurosci Res. 2013 Oct; 91(10):1292-302. Lacan G, Dang H, Middleton B, Horwitz MA, Tian J, Melega WP, Kaufman DL. PMID: 23907992; PMCID: PMC5800426.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    20. Major histocompatibility complex class I molecules modulate embryonic neuritogenesis and neuronal polarization. J Neuroimmunol. 2012 Jun 15; 247(1-2):1-8. Bilousova T, Dang H, Xu W, Gustafson S, Jin Y, Wickramasinghe L, Won T, Bobarnac G, Middleton B, Tian J, Kaufman DL. PMID: 22503373; PMCID: PMC5776040.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    21. Combining antigen-based therapy with GABA treatment synergistically prolongs survival of transplanted ß-cells in diabetic NOD mice. PLoS One. 2011; 6(9):e25337. Tian J, Dang H, Kaufman DL. PMID: 21966502; PMCID: PMC3178649.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    22. Oral treatment with γ-aminobutyric acid improves glucose tolerance and insulin sensitivity by inhibiting inflammation in high fat diet-fed mice. PLoS One. 2011; 6(9):e25338. Tian J, Dang HN, Yong J, Chui WS, Dizon MP, Yaw CK, Kaufman DL. PMID: 21966503; PMCID: PMC3178643.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    23. Oral GABA treatment downregulates inflammatory responses in a mouse model of rheumatoid arthritis. Autoimmunity. 2011 Sep; 44(6):465-70. Tian J, Yong J, Dang H, Kaufman DL. PMID: 21604972; PMCID: PMC5787624.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    24. A potential role for shed soluble major histocompatibility class I molecules as modulators of neurite outgrowth. PLoS One. 2011 Mar 31; 6(3):e18439. Washburn LR, Zekzer D, Eitan S, Lu Y, Dang H, Middleton B, Evans CJ, Tian J, Kaufman DL. PMID: 21483793; PMCID: PMC3069096.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    25. Multimodality imaging of β-cells in mouse models of type 1 and 2 diabetes. Diabetes. 2011 May; 60(5):1383-92. Yong J, Rasooly J, Dang H, Lu Y, Middleton B, Zhang Z, Hon L, Namavari M, Stout DB, Atkinson MA, Tian J, Gambhir SS, Kaufman DL. PMID: 21441442; PMCID: PMC3292311.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    26. BCG vaccine-induced neuroprotection in a mouse model of Parkinson's disease. PLoS One. 2011 Jan 31; 6(1):e16610. Yong J, Lacan G, Dang H, Hsieh T, Middleton B, Wasserfall C, Tian J, Melega WP, Kaufman DL. PMID: 21304945; PMCID: PMC3031604.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsPHPublic Health
    27. Transgenic mice with enhanced neuronal major histocompatibility complex class I expression recover locomotor function better after spinal cord injury. J Neurosci Res. 2011 Mar; 89(3):365-72. Joseph MS, Bilousova T, Zdunowski S, Wu ZP, Middleton B, Boudzinskaia M, Wong B, Ali N, Zhong H, Yong J, Washburn L, Escande-Beillard N, Dang H, Edgerton VR, Tillakaratne NJ, Kaufman DL. PMID: 21259323; PMCID: PMC3087178.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    28. Major histocompatibility complex class I-mediated inhibition of neurite outgrowth from peripheral nerves. Immunol Lett. 2011 Mar 30; 135(1-2):118-23. Wu ZP, Bilousova T, Escande-Beillard N, Dang H, Hsieh T, Tian J, Kaufman DL. PMID: 20974178; PMCID: PMC5776043.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    29. Enhanced neuronal expression of major histocompatibility complex class I leads to aberrations in neurodevelopment and neurorepair. J Neuroimmunol. 2011 Mar; 232(1-2):8-16. Wu ZP, Washburn L, Bilousova TV, Boudzinskaia M, Escande-Beillard N, Querubin J, Dang H, Xie CW, Tian J, Kaufman DL. PMID: 20950866; PMCID: PMC5776042.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    30. Neurons preferentially respond to self-MHC class I allele products regardless of peptide presented. J Immunol. 2010 Jan 15; 184(2):816-23. Escande-Beillard N, Washburn L, Zekzer D, Wu ZP, Eitan S, Ivkovic S, Lu Y, Dang H, Middleton B, Bilousova TV, Yoshimura Y, Evans CJ, Joyce S, Tian J, Kaufman DL. PMID: 20018625; PMCID: PMC2997386.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    31. Transgenically induced GAD tolerance curtails the development of early beta-cell autoreactivities but causes the subsequent development of supernormal autoreactivities to other beta-cell antigens. Diabetes. 2009 Dec; 58(12):2843-50. Tian J, Dang H, von Boehmer H, Jaeckel E, Kaufman DL. PMID: 19741165; PMCID: PMC2780885.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    32. Antigen-based therapy for the treatment of type 1 diabetes. Diabetes. 2009 Sep; 58(9):1939-46. Tian J, Kaufman DL. PMID: 19720821; PMCID: PMC2731536.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    33. Design, synthesis, and antihepatocellular carcinoma activity of nitric oxide releasing derivatives of oleanolic acid. J Med Chem. 2008 Aug 14; 51(15):4834-8. Chen L, Zhang Y, Kong X, Lan E, Huang Z, Peng S, Kaufman DL, Tian J. PMID: 18598019; PMCID: PMC7713708.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    34. The postnatal maternal environment influences diabetes development in nonobese diabetic mice. J Autoimmun. 2007 Feb; 28(1):19-23. Washburn LR, Dang H, Tian J, Kaufman DL. PMID: 17207966; PMCID: PMC1852480.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    35. Long-term monitoring of transplanted islets using positron emission tomography. Mol Ther. 2006 Dec; 14(6):851-6. Lu Y, Dang H, Middleton B, Campbell-Thompson M, Atkinson MA, Gambhir SS, Tian J, Kaufman DL. PMID: 16982215.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    36. Noninvasive imaging of islet grafts using positron-emission tomography. Proc Natl Acad Sci U S A. 2006 Jul 25; 103(30):11294-9. Lu Y, Dang H, Middleton B, Zhang Z, Washburn L, Stout DB, Campbell-Thompson M, Atkinson MA, Phelps M, Gambhir SS, Tian J, Kaufman DL. PMID: 16868090; PMCID: PMC1544080.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    37. B cells are crucial for determinant spreading of T cell autoimmunity among beta cell antigens in diabetes-prone nonobese diabetic mice. J Immunol. 2006 Feb 15; 176(4):2654-61. Tian J, Zekzer D, Lu Y, Dang H, Kaufman DL. PMID: 16456028.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCellsPHPublic Health
    38. Antigen-based therapies using ignored determinants of beta cell antigens can more effectively inhibit late-stage autoimmune disease in diabetes-prone mice. J Immunol. 2005 Aug 01; 175(3):1991-9. Olcott AP, Tian J, Walker V, Dang H, Middleton B, Adorini L, Washburn L, Kaufman DL. PMID: 16034144.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    39. Gamma-aminobutyric acid inhibits T cell autoimmunity and the development of inflammatory responses in a mouse type 1 diabetes model. J Immunol. 2004 Oct 15; 173(8):5298-304. Tian J, Lu Y, Zhang H, Chau CH, Dang HN, Kaufman DL. PMID: 15470076.
      View in: PubMed   Mentions: 96     Fields:    Translation:AnimalsCells
    40. A salen-manganese catalytic free radical scavenger inhibits type 1 diabetes and islet allograft rejection. Diabetes. 2004 Oct; 53(10):2574-80. Olcott AP, Tocco G, Tian J, Zekzer D, Fukuto J, Ignarro L, Kaufman DL. PMID: 15448086.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    41. Bioluminescent monitoring of islet graft survival after transplantation. Mol Ther. 2004 Mar; 9(3):428-35. Lu Y, Dang H, Middleton B, Zhang Z, Washburn L, Campbell-Thompson M, Atkinson MA, Gambhir SS, Tian J, Kaufman DL. PMID: 15006610.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    42. Memory and effector T cells modulate subsequently primed immune responses to unrelated antigens. Cell Immunol. 2003 Aug; 224(2):74-85. Tian J, Lu Y, Hanssen L, Dang H, Kaufman DL. PMID: 14609573.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    43. Murder mysteries in type 1 diabetes. Nat Med. 2003 Feb; 9(2):161-2. Kaufman DL. PMID: 12563331.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    44. Antigen-based immunotherapy drives the precocious development of autoimmunity. J Immunol. 2002 Dec 01; 169(11):6564-9. Tian J, Olcott AP, Kaufman DL. PMID: 12444168.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    45. Report from the 1st International NOD Mouse T-Cell Workshop and the follow-up mini-workshop. Diabetes. 2001 Nov; 50(11):2459-63. Kaufman DL, Tisch R, Sarvetnick N, Chatenoud L, Harrison LC, Haskins K, Quinn A, Sercarz E, Singh B, von Herrath M, Wegmann D, Wen L, Zekzer D. PMID: 11679422.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    46. Lipopolysaccharide-activated B cells down-regulate Th1 immunity and prevent autoimmune diabetes in nonobese diabetic mice. J Immunol. 2001 Jul 15; 167(2):1081-9. Tian J, Zekzer D, Hanssen L, Lu Y, Olcott A, Kaufman DL. PMID: 11441119.
      View in: PubMed   Mentions: 158     Fields:    Translation:AnimalsCells
    47. The frequency of high avidity T cells determines the hierarchy of determinant spreading. J Immunol. 2001 Jun 15; 166(12):7144-50. Tian J, Gregori S, Adorini L, Kaufman DL. PMID: 11390460.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    48. GABA(A) receptors mediate inhibition of T cell responses. J Neuroimmunol. 1999 Apr 01; 96(1):21-8. Tian J, Chau C, Hales TG, Kaufman DL. PMID: 10227421.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCells
    49. Attenuation of inducible Th2 immunity with autoimmune disease progression. J Immunol. 1998 Nov 15; 161(10):5399-403. Tian J, Kaufman DL. PMID: 9820514.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    50. Infectious Th1 and Th2 autoimmunity in diabetes-prone mice. Immunol Rev. 1998 Aug; 164:119-27. Tian J, Olcott AP, Hanssen LR, Zekzer D, Middleton B, Kaufman DL. PMID: 9795770.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    51. Insulin selectively primes Th2 responses and induces regulatory tolerance to insulin in pre-diabetic mice. Diabetologia. 1998 Feb; 41(2):237-40. Tian J, Chau C, Kaufman DL. PMID: 9498660.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    52. Determinant spreading of T helper cell 2 (Th2) responses to pancreatic islet autoantigens. J Exp Med. 1997 Dec 15; 186(12):2039-43. Tian J, Lehmann PV, Kaufman DL. PMID: 9396773; PMCID: PMC2199172.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    53. Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes-prone mice. Nat Med. 1996 Dec; 2(12):1348-53. Tian J, Clare-Salzler M, Herschenfeld A, Middleton B, Newman D, Mueller R, Arita S, Evans C, Atkinson MA, Mullen Y, Sarvetnick N, Tobin AJ, Lehmann PV, Kaufman DL. PMID: 8946834.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    54. Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes. J Exp Med. 1996 Apr 01; 183(4):1561-7. Tian J, Atkinson MA, Clare-Salzler M, Herschenfeld A, Forsthuber T, Lehmann PV, Kaufman DL. PMID: 8666914; PMCID: PMC2192503.
      View in: PubMed   Mentions: 104     Fields:    Translation:AnimalsCells
    55. Human opioid receptors: chromosomal mapping and mRNA localization. NIDA Res Monogr. 1996; 161:72-82. Miotto K, Kaufman D, Anton B, Keith DE, Evans CJ. PMID: 8784845.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    56. Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes. J Clin Invest. 1994 Nov; 94(5):2125-9. Atkinson MA, Bowman MA, Campbell L, Darrow BL, Kaufman DL, Maclaren NK. PMID: 7962558; PMCID: PMC294659.
      View in: PubMed   Mentions: 120     Fields:    Translation:HumansCells
    57. T cell cross-reactivity between coxsackievirus and glutamate decarboxylase is associated with a murine diabetes susceptibility allele. J Exp Med. 1994 Nov 01; 180(5):1979-84. Tian J, Lehmann PV, Kaufman DL. PMID: 7964474; PMCID: PMC2191714.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    58. Comparative localization of two forms of glutamic acid decarboxylase and their mRNAs in rat brain supports the concept of functional differences between the forms. J Neurosci. 1994 Mar; 14(3 Pt 2):1834-55. Esclapez M, Tillakaratne NJ, Kaufman DL, Tobin AJ, Houser CR. PMID: 8126575; PMCID: PMC6577546.
      View in: PubMed   Mentions: 178     Fields:    Translation:Animals
    59. Localization of the delta-opioid receptor gene to mouse chromosome 4 by linkage analysis. Genomics. 1994 Jan 15; 19(2):405-6. Kaufman DL, Xia YR, Keith DE, Newman D, Evans CJ, Lusis AJ. PMID: 8188281.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    60. Horizontal cells in cat and monkey retina express different isoforms of glutamic acid decarboxylase. Vis Neurosci. 1994 Jan-Feb; 11(1):135-42. Vardi N, Kaufman DL, Sterling P. PMID: 8011576.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    61. Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature. 1993 Nov 04; 366(6450):69-72. Kaufman DL, Clare-Salzler M, Tian J, Forsthuber T, Ting GS, Robinson P, Atkinson MA, Sercarz EE, Tobin AJ, Lehmann PV. PMID: 7694152; PMCID: PMC8216222.
      View in: PubMed   Mentions: 251     Fields:    Translation:AnimalsCells
    62. Glutamate decarboxylases and autoimmunity in insulin-dependent diabetes. Trends Pharmacol Sci. 1993 Apr; 14(4):107-9. Kaufman DL, Tobin AJ. PMID: 8516952.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    63. Islet cell cytoplasmic autoantibody reactivity to glutamate decarboxylase in insulin-dependent diabetes. J Clin Invest. 1993 Jan; 91(1):350-6. Atkinson MA, Kaufman DL, Newman D, Tobin AJ, Maclaren NK. PMID: 8423231; PMCID: PMC330033.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    64. Permanent diabetes without serological evidence of autoimmunity after transient neonatal diabetes. Diabetes Care. 1992 Oct; 15(10):1273-6. Gottschalk ME, Schatz DA, Clare-Salzler M, Kaufman DL, Ting GS, Geffner ME. PMID: 1425088.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    65. Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene. Proc Natl Acad Sci U S A. 1992 Mar 15; 89(6):2115-9. Bu DF, Erlander MG, Hitz BC, Tillakaratne NJ, Kaufman DL, Wagner-McPherson CB, Evans GA, Tobin AJ. PMID: 1549570; PMCID: PMC48607.
      View in: PubMed   Mentions: 114     Fields:    Translation:HumansAnimalsCells
    66. Response of peripheral-blood mononuclear cells to glutamate decarboxylase in insulin-dependent diabetes. Lancet. 1992 Feb 22; 339(8791):458-9. Atkinson MA, Kaufman DL, Campbell L, Gibbs KA, Shah SC, Bu DF, Erlander MG, Tobin AJ, Maclaren NK. PMID: 1346821.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    67. Glutamate decarboxylase: an autoantigen in IDDM. Diabetes Care. 1992 Jan; 15(1):132-5. Clare-Salzler MJ, Tobin AJ, Kaufman DL. PMID: 1737532; PMCID: PMC8223701.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    68. Autoimmunity to two forms of glutamate decarboxylase in insulin-dependent diabetes mellitus. J Clin Invest. 1992 Jan; 89(1):283-92. Kaufman DL, Erlander MG, Clare-Salzler M, Atkinson MA, Maclaren NK, Tobin AJ. PMID: 1370298; PMCID: PMC442846.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansCells
    69. Alternative forms of GAD and GABAA receptors. Adv Biochem Psychopharmacol. 1992; 47:55-66. Tobin AJ, Brecha N, Chiang MY, Endo S, Erlander MG, Feldblum S, Houser CR, Kaufman DL, Khrestchatistky M, MacLennan AJ, et al. PMID: 1324588.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    70. Distribution of glutamic acid decarboxylase (Mr 67,000) in the basal ganglia of the rat: an immunohistochemical study with a selective cDNA-generated polyclonal antibody. J Neurocytol. 1991 Dec; 20(12):953-61. Gonzales C, Kaufman DL, Tobin AJ, Chesselet MF. PMID: 1783943.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    71. Two forms of the gamma-aminobutyric acid synthetic enzyme glutamate decarboxylase have distinct intraneuronal distributions and cofactor interactions. J Neurochem. 1991 Feb; 56(2):720-3. Kaufman DL, Houser CR, Tobin AJ. PMID: 1988566; PMCID: PMC8194030.
      View in: PubMed   Mentions: 195     Fields:    Translation:AnimalsCells
    72. Detection of point mutations associated with genetic diseases by an exon scanning technique. Genomics. 1990 Dec; 8(4):656-63. Kaufman DL, Ramesh V, McClatchey AI, Menkes JH, Tobin AJ. PMID: 2276738.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    73. Splicing defect at the ornithine aminotransferase (OAT) locus in gyrate atrophy. Am J Hum Genet. 1990 Nov; 47(5):790-4. McClatchey AI, Kaufman DL, Berson EL, Tobin AJ, Shih VE, Gusella JF, Ramesh V. PMID: 2220818; PMCID: PMC1683684.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    74. Restriction endonuclease cleavage at the termini of PCR products. Biotechniques. 1990 Sep; 9(3):304, 306. Kaufman DL, Evans GA. PMID: 2171587.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    75. Glutamic acid decarboxylase cDNA: nucleotide sequence encoding an enzymatically active fusion protein. J Neurosci. 1987 Sep; 7(9):2768-72. Kobayashi Y, Kaufman DL, Tobin AJ. PMID: 3453123; PMCID: PMC6569140.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    76. Assignment of the rhodopsin gene to human chromosome three, region 3q21-3q24 by in situ hybridization studies. Curr Eye Res. 1986 Oct; 5(10):797-8. Sparkes RS, Klisak I, Kaufman D, Mohandas T, Tobin AJ, McGinnis JF. PMID: 3769527.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    77. In situ hybridization to localize mRNA encoding the neurotransmitter synthetic enzyme glutamate decarboxylase in mouse cerebellum. Proc Natl Acad Sci U S A. 1986 Aug; 83(16):6193-7. Wuenschell CW, Fisher RS, Kaufman DL, Tobin AJ. PMID: 2874558; PMCID: PMC386466.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    78. Assignment of the rhodopsin gene to human chromosome 3. Invest Ophthalmol Vis Sci. 1986 Jul; 27(7):1170-2. Sparkes RS, Mohandas T, Newman SL, Heinzmann C, Kaufman D, Zollman S, Leveille PJ, Tobin AJ, McGinnis JF. PMID: 3459723.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    79. Brain glutamate decarboxylase cloned in lambda gt-11: fusion protein produces gamma-aminobutyric acid. Science. 1986 May 30; 232(4754):1138-40. Kaufman DL, McGinnis JF, Krieger NR, Tobin AJ. PMID: 3518061; PMCID: PMC8194031.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    80. Linkage analysis in a family with dominantly inherited torsion dystonia: exclusion of the pro-opiomelanocortin and glutamic acid decarboxylase genes and other chromosomal regions using DNA polymorphisms. J Neurogenet. 1986 May; 3(3):159-75. Breakefield XO, Bressman SB, Kramer PL, Ozelius L, Moskowitz C, Tanzi R, Brin MF, Hobbs W, Kaufman D, Tobin A, et al. PMID: 3016220.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
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