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Daniel L Kaufman

Title(s)Professor, Molecular and Medical Pharmacology
SchoolMedicine
Phone3107949664
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    Collapse Research 
    Collapse Research Activities and Funding
    Oral GABA treatment as a novel and safe therapy to ameliorate Sjögren?s syndrome
    NIH/NIDCR R21DE029020Jul 1, 2019 - Jun 30, 2021
    Role: Principal Investigator
    Repurposing lesogaberan for the treatment of type 1 diabetes
    NIH/NCATS R21TR001742Sep 1, 2016 - Jul 31, 2018
    Role: Principal Investigator
    Combination immunotherapy to preserve beta-cell function in the context of autoimmunity
    NIH/NIAID R21AI119831Jan 1, 2016 - Dec 31, 2017
    Role: Principal Investigator
    Reversal of T1D in NOD mice using a safe combination therapy
    NIH/NIDDK R01DK092480May 1, 2012 - Apr 30, 2016
    Role: Principal Investigator
    Multimodality imaging of beta-cell in anaimal models of T1DM and T2DM
    NIH/NIDDK R21DK080461Sep 30, 2008 - Jun 30, 2010
    Role: Principal Investigator
    Characterizing autoimmunity in NOD mouse islets, PLN and spleen
    NIH/NIDDK R21DK075070Sep 15, 2006 - Aug 31, 2009
    Role: Principal Investigator
    Characterizing MHCI's neuroactivity
    NIH/NINDS R21NS053847Jan 1, 2006 - Dec 31, 2007
    Role: Principal Investigator
    A Neuroprotective Vaccine for Parkinson's Disease
    NIH/NINDS R21NS049121Apr 15, 2005 - Mar 31, 2008
    Role: Principal Investigator
    Noninvasive PET Imaging of Islet Grafts
    NIH/NIDDK R21DK069839Sep 30, 2004 - Aug 31, 2007
    Role: Principal Investigator
    Noninvasive islet graft imaging by PET
    NIH/NIDDK R01DK068506Sep 1, 2004 - Feb 29, 2008
    Role: Principal Investigator
    MHCI Inhibition of Neuronal Repair Responses
    NIH/NINDS R21NS047383Jul 1, 2004 - Apr 30, 2007
    Role: Principal Investigator
    Prevention of IDDM by Expression of a Modified I-Ag7
    NIH/NIDDK R21DK060211Sep 1, 2001 - Aug 31, 2003
    Role: Principal Investigator
    NONINVASIVE BETA CELL IMAGING BY PET
    NIH/NIDDK R01DK058514Sep 30, 2000 - Sep 29, 2004
    Role: Principal Investigator
    RATIONAL DESIGN OF ANTIGEN-BASED IMMUNOTHERAPEUTICS
    NIH/NIAID R21AI047773Sep 30, 1999 - Sep 29, 2001
    Role: Principal Investigator
    GAD BASED IMMUNOTHERAPY FOR MURINE DIABETES
    NIH/NIDDK R01DK048455Jun 21, 1999 - Aug 31, 2002
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Tian J, Dang H, O'Laco KA, Song M, Tiu BC, Gilles S, Zakarian C, Kaufman DL. Homotaurine Treatment Enhances CD4+ and CD8+ Regulatory T Cell Responses and Synergizes with Low-Dose Anti-CD3 to Enhance Diabetes Remission in Type 1 Diabetic Mice. Immunohorizons. 2019 10 21; 3(10):498-510. PMID: 31636084.
      View in: PubMed
    2. Yong J, Tian J, Dang H, Wu TT, Atkinson MA, Sun R, Kaufman DL. Increased risk for T cell autoreactivity to ß-cell antigens in the mice expressing the Avy obesity-associated gene. Sci Rep. 2019 03 12; 9(1):4269. PMID: 30862859.
      View in: PubMed
    3. Tian J, Dang H, Karashchuk N, Xu I, Kaufman DL. A Clinically Applicable Positive Allosteric Modulator of GABA Receptors Promotes Human ß-Cell Replication and Survival as well as GABA's Ability to Inhibit Inflammatory T Cells. J Diabetes Res. 2019; 2019:5783545. PMID: 30937314.
      View in: PubMed
    4. Tian J, Dang H, Wallner M, Olsen R, Kaufman DL. Homotaurine, a safe blood-brain barrier permeable GABAA-R-specific agonist, ameliorates disease in mouse models of multiple sclerosis. Sci Rep. 2018 11 08; 8(1):16555. PMID: 30410049.
      View in: PubMed
    5. Tian J, Dang H, Hu A, Xu W, Kaufman DL. Repurposing Lesogaberan to Promote Human Islet Cell Survival and ß-Cell Replication. J Diabetes Res. 2017; 2017:6403539. PMID: 29018828.
      View in: PubMed
    6. Tian J, Dang H, Middleton B, Kaufman DL. Clinically applicable GABA receptor positive allosteric modulators promote ß-cell replication. Sci Rep. 2017 03 23; 7(1):374. PMID: 28336918.
      View in: PubMed
    7. Tian J, Dang H, Nguyen AV, Chen Z, Kaufman DL. Combined therapy with GABA and proinsulin/alum acts synergistically to restore long-term normoglycemia by modulating T-cell autoimmunity and promoting ß-cell replication in newly diabetic NOD mice. Diabetes. 2014 Sep; 63(9):3128-34. PMID: 25146474.
      View in: PubMed
    8. Tian J, Dang H, Chen Z, Guan A, Jin Y, Atkinson MA, Kaufman DL. ?-Aminobutyric acid regulates both the survival and replication of human ß-cells. Diabetes. 2013 Nov; 62(11):3760-5. PMID: 23995958.
      View in: PubMed
    9. Lacan G, Dang H, Middleton B, Horwitz MA, Tian J, Melega WP, Kaufman DL. Bacillus Calmette-Guerin vaccine-mediated neuroprotection is associated with regulatory T-cell induction in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. J Neurosci Res. 2013 Oct; 91(10):1292-302. PMID: 23907992.
      View in: PubMed
    10. Bilousova T, Dang H, Xu W, Gustafson S, Jin Y, Wickramasinghe L, Won T, Bobarnac G, Middleton B, Tian J, Kaufman DL. Major histocompatibility complex class I molecules modulate embryonic neuritogenesis and neuronal polarization. J Neuroimmunol. 2012 Jun 15; 247(1-2):1-8. PMID: 22503373.
      View in: PubMed
    11. Tian J, Dang H, Kaufman DL. Combining antigen-based therapy with GABA treatment synergistically prolongs survival of transplanted ß-cells in diabetic NOD mice. PLoS One. 2011; 6(9):e25337. PMID: 21966502.
      View in: PubMed
    12. Tian J, Dang HN, Yong J, Chui WS, Dizon MP, Yaw CK, Kaufman DL. Oral treatment with ?-aminobutyric acid improves glucose tolerance and insulin sensitivity by inhibiting inflammation in high fat diet-fed mice. PLoS One. 2011; 6(9):e25338. PMID: 21966503.
      View in: PubMed
    13. Tian J, Yong J, Dang H, Kaufman DL. Oral GABA treatment downregulates inflammatory responses in a mouse model of rheumatoid arthritis. Autoimmunity. 2011 Sep; 44(6):465-70. PMID: 21604972.
      View in: PubMed
    14. Washburn LR, Zekzer D, Eitan S, Lu Y, Dang H, Middleton B, Evans CJ, Tian J, Kaufman DL. A potential role for shed soluble major histocompatibility class I molecules as modulators of neurite outgrowth. PLoS One. 2011 Mar 31; 6(3):e18439. PMID: 21483793.
      View in: PubMed
    15. Yong J, Rasooly J, Dang H, Lu Y, Middleton B, Zhang Z, Hon L, Namavari M, Stout DB, Atkinson MA, Tian J, Gambhir SS, Kaufman DL. Multimodality imaging of ß-cells in mouse models of type 1 and 2 diabetes. Diabetes. 2011 May; 60(5):1383-92. PMID: 21441442.
      View in: PubMed
    16. Yong J, Lacan G, Dang H, Hsieh T, Middleton B, Wasserfall C, Tian J, Melega WP, Kaufman DL. BCG vaccine-induced neuroprotection in a mouse model of Parkinson's disease. PLoS One. 2011 Jan 31; 6(1):e16610. PMID: 21304945.
      View in: PubMed
    17. Joseph MS, Bilousova T, Zdunowski S, Wu ZP, Middleton B, Boudzinskaia M, Wong B, Ali N, Zhong H, Yong J, Washburn L, Escande-Beillard N, Dang H, Edgerton VR, Tillakaratne NJ, Kaufman DL. Transgenic mice with enhanced neuronal major histocompatibility complex class I expression recover locomotor function better after spinal cord injury. J Neurosci Res. 2011 Mar; 89(3):365-72. PMID: 21259323.
      View in: PubMed
    18. Wu ZP, Bilousova T, Escande-Beillard N, Dang H, Hsieh T, Tian J, Kaufman DL. Major histocompatibility complex class I-mediated inhibition of neurite outgrowth from peripheral nerves. Immunol Lett. 2011 Mar 30; 135(1-2):118-23. PMID: 20974178.
      View in: PubMed
    19. Wu ZP, Washburn L, Bilousova TV, Boudzinskaia M, Escande-Beillard N, Querubin J, Dang H, Xie CW, Tian J, Kaufman DL. Enhanced neuronal expression of major histocompatibility complex class I leads to aberrations in neurodevelopment and neurorepair. J Neuroimmunol. 2011 Mar; 232(1-2):8-16. PMID: 20950866.
      View in: PubMed
    20. Escande-Beillard N, Washburn L, Zekzer D, Wu ZP, Eitan S, Ivkovic S, Lu Y, Dang H, Middleton B, Bilousova TV, Yoshimura Y, Evans CJ, Joyce S, Tian J, Kaufman DL. Neurons preferentially respond to self-MHC class I allele products regardless of peptide presented. J Immunol. 2010 Jan 15; 184(2):816-23. PMID: 20018625.
      View in: PubMed
    21. Tian J, Dang H, von Boehmer H, Jaeckel E, Kaufman DL. Transgenically induced GAD tolerance curtails the development of early beta-cell autoreactivities but causes the subsequent development of supernormal autoreactivities to other beta-cell antigens. Diabetes. 2009 Dec; 58(12):2843-50. PMID: 19741165.
      View in: PubMed
    22. Tian J, Kaufman DL. Antigen-based therapy for the treatment of type 1 diabetes. Diabetes. 2009 Sep; 58(9):1939-46. PMID: 19720821.
      View in: PubMed
    23. Chen L, Zhang Y, Kong X, Lan E, Huang Z, Peng S, Kaufman DL, Tian J. Design, synthesis, and antihepatocellular carcinoma activity of nitric oxide releasing derivatives of oleanolic acid. J Med Chem. 2008 Aug 14; 51(15):4834-8. PMID: 18598019.
      View in: PubMed
    24. Lu Y, Dang H, Middleton B, Campbell-Thompson M, Atkinson MA, Gambhir SS, Tian J, Kaufman DL. Long-term monitoring of transplanted islets using positron emission tomography. Mol Ther. 2006 Dec; 14(6):851-6. PMID: 16982215.
      View in: PubMed
    25. Lu Y, Dang H, Middleton B, Zhang Z, Washburn L, Stout DB, Campbell-Thompson M, Atkinson MA, Phelps M, Gambhir SS, Tian J, Kaufman DL. Noninvasive imaging of islet grafts using positron-emission tomography. Proc Natl Acad Sci U S A. 2006 Jul 25; 103(30):11294-9. PMID: 16868090.
      View in: PubMed
    26. Tian J, Zekzer D, Lu Y, Dang H, Kaufman DL. B cells are crucial for determinant spreading of T cell autoimmunity among beta cell antigens in diabetes-prone nonobese diabetic mice. J Immunol. 2006 Feb 15; 176(4):2654-61. PMID: 16456028.
      View in: PubMed
    27. Olcott AP, Tian J, Walker V, Dang H, Middleton B, Adorini L, Washburn L, Kaufman DL. Antigen-based therapies using ignored determinants of beta cell antigens can more effectively inhibit late-stage autoimmune disease in diabetes-prone mice. J Immunol. 2005 Aug 01; 175(3):1991-9. PMID: 16034144.
      View in: PubMed
    28. Tian J, Lu Y, Zhang H, Chau CH, Dang HN, Kaufman DL. Gamma-aminobutyric acid inhibits T cell autoimmunity and the development of inflammatory responses in a mouse type 1 diabetes model. J Immunol. 2004 Oct 15; 173(8):5298-304. PMID: 15470076.
      View in: PubMed
    29. Olcott AP, Tocco G, Tian J, Zekzer D, Fukuto J, Ignarro L, Kaufman DL. A salen-manganese catalytic free radical scavenger inhibits type 1 diabetes and islet allograft rejection. Diabetes. 2004 Oct; 53(10):2574-80. PMID: 15448086.
      View in: PubMed
    30. Lu Y, Dang H, Middleton B, Zhang Z, Washburn L, Campbell-Thompson M, Atkinson MA, Gambhir SS, Tian J, Kaufman DL. Bioluminescent monitoring of islet graft survival after transplantation. Mol Ther. 2004 Mar; 9(3):428-35. PMID: 15006610.
      View in: PubMed
    31. Tian J, Lu Y, Hanssen L, Dang H, Kaufman DL. Memory and effector T cells modulate subsequently primed immune responses to unrelated antigens. Cell Immunol. 2003 Aug; 224(2):74-85. PMID: 14609573.
      View in: PubMed
    32. Kaufman DL. Murder mysteries in type 1 diabetes. Nat Med. 2003 Feb; 9(2):161-2. PMID: 12563331.
      View in: PubMed
    33. Tian J, Olcott AP, Kaufman DL. Antigen-based immunotherapy drives the precocious development of autoimmunity. J Immunol. 2002 Dec 01; 169(11):6564-9. PMID: 12444168.
      View in: PubMed
    34. Kaufman DL, Tisch R, Sarvetnick N, Chatenoud L, Harrison LC, Haskins K, Quinn A, Sercarz E, Singh B, von Herrath M, Wegmann D, Wen L, Zekzer D. Report from the 1st International NOD Mouse T-Cell Workshop and the follow-up mini-workshop. Diabetes. 2001 Nov; 50(11):2459-63. PMID: 11679422.
      View in: PubMed