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Anne Pascale Beigneux

Title(s)Adjunct Professor, Medicine
SchoolMedicine
Address760 Westwood Plaza 32-144
Los Angeles CA 90024
Phone59422
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    Collapse Research 
    Collapse Research Activities and Funding
    New Avenues in GPIHBP1 Research
    NIH R01HL094732Apr 1, 2009 - Jun 30, 2011
    Role: Principal Investigator
    A new mechanism for human hypertriglyceridemia and new avenues for investigating intravascular triglyceride metabolism
    NIH R01HL087228Feb 1, 2007 - Dec 31, 2016
    Role: Co-Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chylomicronemia from GPIHBP1 autoantibodies. J Lipid Res. 2020 Nov; 61(11):1365-1376. Miyashita K, Lutz J, Hudgins LC, Toib D, Ashraf AP, Song W, Murakami M, Nakajima K, Ploug M, Fong LG, Young SG, Beigneux AP. PMID: 32948662.
      View in: PubMed   Mentions:    Fields:    
    2. Chylomicronemia From GPIHBP1 Autoantibodies Successfully Treated With Rituximab: A Case Report. Ann Intern Med. 2020 11 03; 173(9):764-765. Lutz J, Dunaj-Kazmierowska M, Arcan S, Kassner U, Miyashita K, Murakami M, Ploug M, Fong LG, Young SG, Nakajima K, Beigneux AP. PMID: 32777186.
      View in: PubMed   Mentions: 1     Fields:    
    3. The structural basis for monoclonal antibody 5D2 binding to the tryptophan-rich loop of lipoprotein lipase. J Lipid Res. 2020 Oct; 61(10):1347-1359. Luz JG, Beigneux AP, Asamoto DK, He C, Song W, Allan CM, Morales J, Tu Y, Kwok A, Cottle T, Meiyappan M, Fong LG, Kim JE, Ploug M, Young SG, Birrane G. PMID: 32690595.
      View in: PubMed   Mentions: 1     Fields:    
    4. Intermittent chylomicronemia caused by intermittent GPIHBP1 autoantibodies. J Clin Lipidol. 2020 Mar - Apr; 14(2):197-200. Ashraf AP, Miyashita K, Nakajima K, Murakami M, Hegele RA, Ploug M, Fong LG, Young SG, Beigneux AP. PMID: 32107180.
      View in: PubMed   Mentions: 2     Fields:    
    5. GPIHBP1 and Lipoprotein Lipase, Partners in Plasma Triglyceride Metabolism. Cell Metab. 2019 07 02; 30(1):51-65. Young SG, Fong LG, Beigneux AP, Allan CM, He C, Jiang H, Nakajima K, Meiyappan M, Birrane G, Ploug M. PMID: 31269429.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    6. GPIHBP1 expression in gliomas promotes utilization of lipoprotein-derived nutrients. Elife. 2019 06 06; 8. Hu X, Matsumoto K, Jung RS, Weston TA, Heizer PJ, He C, Sandoval NP, Allan CM, Tu Y, Vinters HV, Liau LM, Ellison RM, Morales JE, Baufeld LJ, Bayley NA, He L, Betsholtz C, Beigneux AP, Nathanson DA, Gerhardt H, Young SG, Fong LG, Jiang H. PMID: 31169500.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    7. Lipoprotein lipase is active as a monomer. Proc Natl Acad Sci U S A. 2019 03 26; 116(13):6319-6328. Beigneux AP, Allan CM, Sandoval NP, Cho GW, Heizer PJ, Jung RS, Stanhope KL, Havel PJ, Birrane G, Meiyappan M, Gill JE, Murakami M, Miyashita K, Nakajima K, Ploug M, Fong LG, Young SG. PMID: 30850549.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    8. An upstream enhancer regulates Gpihbp1 expression in a tissue-specific manner. J Lipid Res. 2019 04; 60(4):869-879. Allan CM, Heizer PJ, Tu Y, Sandoval NP, Jung RS, Morales JE, Sajti E, Troutman TD, Saunders TL, Cusanovich DA, Beigneux AP, Romanoski CE, Fong LG, Young SG. PMID: 30598475.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    9. Structure of the lipoprotein lipase-GPIHBP1 complex that mediates plasma triglyceride hydrolysis. Proc Natl Acad Sci U S A. 2019 01 29; 116(5):1723-1732. Birrane G, Beigneux AP, Dwyer B, Strack-Logue B, Kristensen KK, Francone OL, Fong LG, Mertens HDT, Pan CQ, Ploug M, Young SG, Meiyappan M. PMID: 30559189.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    10. GPIHBP1 autoantibody syndrome during interferon ß1a treatment. J Clin Lipidol. 2019 Jan - Feb; 13(1):62-69. Eguchi J, Miyashita K, Fukamachi I, Nakajima K, Murakami M, Kawahara Y, Yamashita T, Ohta Y, Abe K, Nakatsuka A, Mino M, Takase S, Okazaki H, Hegele RA, Ploug M, Hu X, Wada J, Young SG, Beigneux AP. PMID: 30514621.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    11. An ELISA for quantifying GPIHBP1 autoantibodies and making a diagnosis of the GPIHBP1 autoantibody syndrome. Clin Chim Acta. 2018 Dec; 487:174-178. Miyashita K, Fukamachi I, Machida T, Nakajima K, Young SG, Murakami M, Beigneux AP, Nakajima K. PMID: 30287259.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    12. A disordered acidic domain in GPIHBP1 harboring a sulfated tyrosine regulates lipoprotein lipase. Proc Natl Acad Sci U S A. 2018 06 26; 115(26):E6020-E6029. Kristensen KK, Midtgaard SR, Mysling S, Kovrov O, Hansen LB, Skar-Gislinge N, Beigneux AP, Kragelund BB, Olivecrona G, Young SG, Jørgensen TJD, Fong LG, Ploug M. PMID: 29899144.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    13. NanoSIMS Analysis of Intravascular Lipolysis and Lipid Movement across Capillaries and into Cardiomyocytes. Cell Metab. 2018 May 01; 27(5):1055-1066.e3. He C, Weston TA, Jung RS, Heizer P, Larsson M, Hu X, Allan CM, Tontonoz P, Reue K, Beigneux AP, Ploug M, Holme A, Kilburn M, Guagliardo P, Ford DA, Fong LG, Young SG, Jiang H. PMID: 29719224.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    14. Impaired thermogenesis and sharp increases in plasma triglyceride levels in GPIHBP1-deficient mice during cold exposure. J Lipid Res. 2018 04; 59(4):706-713. Larsson M, Allan CM, Heizer PJ, Tu Y, Sandoval NP, Jung RS, Walzem RL, Beigneux AP, Young SG, Fong LG. PMID: 29449313.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    15. An enzyme-linked immunosorbent assay for measuring GPIHBP1 levels in human plasma or serum. J Clin Lipidol. 2018 Jan - Feb; 12(1):203-210.e1. Miyashita K, Fukamachi I, Nagao M, Ishida T, Kobayashi J, Machida T, Nakajima K, Murakami M, Ploug M, Beigneux AP, Young SG, Nakajima K. PMID: 29246728.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    16. Lipoprotein lipase reaches the capillary lumen in chickens despite an apparent absence of GPIHBP1. JCI Insight. 2017 10 19; 2(20). He C, Hu X, Jung RS, Larsson M, Tu Y, Duarte-Vogel S, Kim P, Sandoval NP, Price TR, Allan CM, Raney B, Jiang H, Bensadoun A, Walzem RL, Kuo RI, Beigneux AP, Fong LG, Young SG. PMID: 29046479.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    17. Palmoplantar keratoderma in Slurp1/Slurp2 double-knockout mice. J Dermatol Sci. 2018 Jan; 89(1):85-87. Allan CM, Heizer PJ, Jung CJ, Tu Y, Tran D, Young LC, Fong LG, de Jong PJ, Beigneux AP, Young SG. PMID: 29017797.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    18. A hypomorphic Egfr allele does not ameliorate the palmoplantar keratoderma caused by SLURP1 deficiency. Exp Dermatol. 2017 11; 26(11):1134-1136. Allan CM, Tran D, Tu Y, Heizer PJ, Young LC, Fong LG, Beigneux AP, Young SG. PMID: 28418591.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    19. Apolipoprotein C-III inhibits triglyceride hydrolysis by GPIHBP1-bound LPL. J Lipid Res. 2017 09; 58(9):1893-1902. Larsson M, Allan CM, Jung RS, Heizer PJ, Beigneux AP, Young SG, Fong LG. PMID: 28694296.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    20. GPIHBP1 autoantibodies in a patient with unexplained chylomicronemia. J Clin Lipidol. 2017 Jul - Aug; 11(4):964-971. Hu X, Dallinga-Thie GM, Hovingh GK, Chang SY, Sandoval NP, Dang TLP, Fukamachi I, Miyashita K, Nakajima K, Murakami M, Fong LG, Ploug M, Young SG, Beigneux AP. PMID: 28666713.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    21. Mutating a conserved cysteine in GPIHBP1 reduces amounts of GPIHBP1 in capillaries and abolishes LPL binding. J Lipid Res. 2017 07; 58(7):1453-1461. Allan CM, Jung CJ, Larsson M, Heizer PJ, Tu Y, Sandoval NP, Dang TLP, Jung RS, Beigneux AP, de Jong PJ, Fong LG, Young SG. PMID: 28476858.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    22. Autoantibodies against GPIHBP1 as a Cause of Hypertriglyceridemia. N Engl J Med. 2017 04 27; 376(17):1647-1658. Beigneux AP, Miyashita K, Ploug M, Blom DJ, Ai M, Linton MF, Khovidhunkit W, Dufour R, Garg A, McMahon MA, Pullinger CR, Sandoval NP, Hu X, Allan CM, Larsson M, Machida T, Murakami M, Reue K, Tontonoz P, Goldberg IJ, Moulin P, Charrière S, Fong LG, Nakajima K, Young SG. PMID: 28402248.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    23. Monoclonal antibodies that bind to the Ly6 domain of GPIHBP1 abolish the binding of LPL. J Lipid Res. 2017 01; 58(1):208-215. Hu X, Sleeman MW, Miyashita K, Linton MF, Allan CM, He C, Larsson M, Tu Y, Sandoval NP, Jung RS, Mapar A, Machida T, Murakami M, Nakajima K, Ploug M, Fong LG, Young SG, Beigneux AP. PMID: 27875259.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    24. Mobility of "HSPG-bound" LPL explains how LPL is able to reach GPIHBP1 on capillaries. J Lipid Res. 2017 01; 58(1):216-225. Allan CM, Larsson M, Jung RS, Ploug M, Bensadoun A, Beigneux AP, Fong LG, Young SG. PMID: 27811232.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    25. An LPL-specific monoclonal antibody, 88B8, that abolishes the binding of LPL to GPIHBP1. J Lipid Res. 2016 10; 57(10):1889-1898. Allan CM, Larsson M, Hu X, He C, Jung RS, Mapar A, Voss C, Miyashita K, Machida T, Murakami M, Nakajima K, Bensadoun A, Ploug M, Fong LG, Young SG, Beigneux AP. PMID: 27494936.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    26. GPIHBP1 and Plasma Triglyceride Metabolism. Trends Endocrinol Metab. 2016 07; 27(7):455-469. Fong LG, Young SG, Beigneux AP, Bensadoun A, Oberer M, Jiang H, Ploug M. PMID: 27185325.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    27. Angiopoietin-like 4 promotes intracellular degradation of lipoprotein lipase in adipocytes. J Lipid Res. 2016 09; 57(9):1670-83. Dijk W, Beigneux AP, Larsson M, Bensadoun A, Young SG, Kersten S. PMID: 27034464.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    28. The acidic domain of the endothelial membrane protein GPIHBP1 stabilizes lipoprotein lipase activity by preventing unfolding of its catalytic domain. Elife. 2016 Jan 03; 5:e12095. Mysling S, Kristensen KK, Larsson M, Beigneux AP, Gårdsvoll H, Fong LG, Bensadouen A, Jørgensen TJ, Young SG, Ploug M. PMID: 26725083.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    29. Palmoplantar Keratoderma in Slurp2-Deficient Mice. J Invest Dermatol. 2016 Feb; 136(2):436-443. Allan CM, Procaccia S, Tran D, Tu Y, Barnes RH, Larsson M, Allan BB, Young LC, Hong C, Tontonoz P, Fong LG, Young SG, Beigneux AP. PMID: 26967477.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    30. Heterogeneity in the properties of mutant secreted lymphocyte antigen 6/urokinase receptor-related protein 1 (SLURP1) in Mal de Meleda. Br J Dermatol. 2015 Oct; 173(4):1066-9. Adeyo O, Oberer M, Ploug M, Fong LG, Young SG, Beigneux AP. PMID: 25919322.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    31. GPIHBP1 missense mutations often cause multimerization of GPIHBP1 and thereby prevent lipoprotein lipase binding. Circ Res. 2015 Feb 13; 116(4):624-32. Beigneux AP, Fong LG, Bensadoun A, Davies BS, Oberer M, Gårdsvoll H, Ploug M, Young SG. PMID: 25387803.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    32. High-resolution imaging of dietary lipids in cells and tissues by NanoSIMS analysis. J Lipid Res. 2014 Oct; 55(10):2156-66. Jiang H, Goulbourne CN, Tatar A, Turlo K, Wu D, Beigneux AP, Grovenor CR, Fong LG, Young SG. PMID: 25143463.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    33. Multimerization of glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) and familial chylomicronemia from a serine-to-cysteine substitution in GPIHBP1 Ly6 domain. J Biol Chem. 2014 Jul 11; 289(28):19491-9. Plengpanich W, Young SG, Khovidhunkit W, Bensadoun A, Karnman H, Ploug M, Gårdsvoll H, Leung CS, Adeyo O, Larsson M, Muanpetch S, Charoen S, Fong LG, Niramitmahapanya S, Beigneux AP. PMID: 24847059.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCellsCTClinical Trials
    34. The GPIHBP1-LPL complex is responsible for the margination of triglyceride-rich lipoproteins in capillaries. Cell Metab. 2014 May 06; 19(5):849-60. Goulbourne CN, Gin P, Tatar A, Nobumori C, Hoenger A, Jiang H, Grovenor CR, Adeyo O, Esko JD, Goldberg IJ, Reue K, Tontonoz P, Bensadoun A, Beigneux AP, Young SG, Fong LG. PMID: 24726386.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    35. Equivalent binding of wild-type lipoprotein lipase (LPL) and S447X-LPL to GPIHBP1, the endothelial cell LPL transporter. Biochim Biophys Acta. 2014 Jul; 1841(7):963-9. Turlo K, Leung CS, Seo JJ, Goulbourne CN, Adeyo O, Gin P, Voss C, Bensadoun A, Fong LG, Young SG, Beigneux AP. PMID: 24704550.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    36. A new monoclonal antibody, 4-1a, that binds to the amino terminus of human lipoprotein lipase. Biochim Biophys Acta. 2014 Jul; 1841(7):970-6. Bensadoun A, Mottler CD, Pelletier C, Wu D, Seo JJ, Leung CS, Adeyo O, Goulbourne CN, Gin P, Fong LG, Young SG, Beigneux AP. PMID: 24681165.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    37. Palmoplantar keratoderma along with neuromuscular and metabolic phenotypes in Slurp1-deficient mice. J Invest Dermatol. 2014 Jun; 134(6):1589-1598. Adeyo O, Allan BB, Barnes RH, Goulbourne CN, Tatar A, Tu Y, Young LC, Weinstein MM, Tontonoz P, Fong LG, Beigneux AP, Young SG. PMID: 24499735.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    38. Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 and the intravascular processing of triglyceride-rich lipoproteins. J Intern Med. 2012 Dec; 272(6):528-40. Adeyo O, Goulbourne CN, Bensadoun A, Beigneux AP, Fong LG, Young SG. PMID: 23020258.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    39. Assessing mechanisms of GPIHBP1 and lipoprotein lipase movement across endothelial cells. J Lipid Res. 2012 Dec; 53(12):2690-7. Davies BS, Goulbourne CN, Barnes RH, Turlo KA, Gin P, Vaughan S, Vaux DJ, Bensadoun A, Beigneux AP, Fong LG, Young SG. PMID: 23008484.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    40. Chylomicronemia mutations yield new insights into interactions between lipoprotein lipase and GPIHBP1. Hum Mol Genet. 2012 Jul 01; 21(13):2961-72. Gin P, Goulbourne CN, Adeyo O, Beigneux AP, Davies BS, Tat S, Voss CV, Bensadoun A, Fong LG, Young SG. PMID: 22493000.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    41. New wrinkles in lipoprotein lipase biology. Curr Opin Lipidol. 2012 Feb; 23(1):35-42. Davies BS, Beigneux AP, Fong LG, Young SG. PMID: 22123668.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    42. Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA. Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7):E423-31. Jung HJ, Coffinier C, Choe Y, Beigneux AP, Davies BS, Yang SH, Barnes RH, Hong J, Sun T, Pleasure SJ, Young SG, Fong LG. PMID: 22308344.
      View in: PubMed   Mentions: 75     Fields:    Translation:Animals
    43. Reciprocal metabolic perturbations in the adipose tissue and liver of GPIHBP1-deficient mice. Arterioscler Thromb Vasc Biol. 2012 Feb; 32(2):230-5. Weinstein MM, Goulbourne CN, Davies BS, Tu Y, Barnes RH, Watkins SM, Davis R, Reue K, Tontonoz P, Beigneux AP, Fong LG, Young SG. PMID: 22173228.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    44. GPIHBP1, an endothelial cell transporter for lipoprotein lipase. J Lipid Res. 2011 Nov; 52(11):1869-84. Young SG, Davies BS, Voss CV, Gin P, Weinstein MM, Tontonoz P, Reue K, Bensadoun A, Fong LG, Beigneux AP. PMID: 21844202.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    45. Mutations in lipoprotein lipase that block binding to the endothelial cell transporter GPIHBP1. Proc Natl Acad Sci U S A. 2011 May 10; 108(19):7980-4. Voss CV, Davies BS, Tat S, Gin P, Fong LG, Pelletier C, Mottler CD, Bensadoun A, Beigneux AP, Young SG. PMID: 21518912.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    46. Assessing the role of the glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) three-finger domain in binding lipoprotein lipase. J Biol Chem. 2011 Jun 03; 286(22):19735-43. Beigneux AP, Davies BS, Tat S, Chen J, Gin P, Voss CV, Weinstein MM, Bensadoun A, Pullinger CR, Fong LG, Young SG. PMID: 21478160.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    47. Binding preferences for GPIHBP1, a glycosylphosphatidylinositol-anchored protein of capillary endothelial cells. Arterioscler Thromb Vasc Biol. 2011 Jan; 31(1):176-82. Gin P, Beigneux AP, Voss C, Davies BS, Beckstead JA, Ryan RO, Bensadoun A, Fong LG, Young SG. PMID: 20966398.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    48. Unexpected expression pattern for glycosylphosphatidylinositol-anchored HDL-binding protein 1 (GPIHBP1) in mouse tissues revealed by positron emission tomography scanning. J Biol Chem. 2010 Dec 10; 285(50):39239-48. Olafsen T, Young SG, Davies BS, Beigneux AP, Kenanova VE, Voss C, Young G, Wong KP, Barnes RH, Tu Y, Weinstein MM, Nobumori C, Huang SC, Goldberg IJ, Bensadoun A, Wu AM, Fong LG. PMID: 20889497.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    49. Cholesterol intake modulates plasma triglyceride levels in glycosylphosphatidylinositol HDL-binding protein 1-deficient mice. Arterioscler Thromb Vasc Biol. 2010 Nov; 30(11):2106-13. Weinstein MM, Tu Y, Beigneux AP, Davies BS, Gin P, Voss C, Walzem RL, Reue K, Tontonoz P, Bensadoun A, Fong LG, Young SG. PMID: 20814015.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    50. GPIHBP1 and the processing of triglyceride-rich lipoproteins. Clin Lipidol. 2010 Aug 01; 5(4):575-582. Beigneux AP. PMID: 20953295.
      View in: PubMed   Mentions:
    51. GPIHBP1 is responsible for the entry of lipoprotein lipase into capillaries. Cell Metab. 2010 Jul 07; 12(1):42-52. Davies BS, Beigneux AP, Barnes RH, Tu Y, Gin P, Weinstein MM, Nobumori C, Nyrén R, Goldberg I, Olivecrona G, Bensadoun A, Young SG, Fong LG. PMID: 20620994.
      View in: PubMed   Mentions: 125     Fields:    Translation:AnimalsCells
    52. Chylomicronemia with low postheparin lipoprotein lipase levels in the setting of GPIHBP1 defects. Circ Cardiovasc Genet. 2010 Apr; 3(2):169-78. Franssen R, Young SG, Peelman F, Hertecant J, Sierts JA, Schimmel AW, Bensadoun A, Kastelein JJ, Fong LG, Dallinga-Thie GM, Beigneux AP. PMID: 20124439.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    53. Mutation of conserved cysteines in the Ly6 domain of GPIHBP1 in familial chylomicronemia. J Lipid Res. 2010 Jun; 51(6):1535-45. Olivecrona G, Ehrenborg E, Semb H, Makoveichuk E, Lindberg A, Hayden MR, Gin P, Davies BS, Weinstein MM, Fong LG, Beigneux AP, Young SG, Olivecrona T, Hernell O. PMID: 20026666.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    54. Chylomicronemia elicits atherosclerosis in mice--brief report. Arterioscler Thromb Vasc Biol. 2010 Jan; 30(1):20-3. Weinstein MM, Yin L, Tu Y, Wang X, Wu X, Castellani LW, Walzem RL, Lusis AJ, Fong LG, Beigneux AP, Young SG. PMID: 19815815.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    55. Highly conserved cysteines within the Ly6 domain of GPIHBP1 are crucial for the binding of lipoprotein lipase. J Biol Chem. 2009 Oct 30; 284(44):30240-7. Beigneux AP, Gin P, Davies BS, Weinstein MM, Bensadoun A, Fong LG, Young SG. PMID: 19726683.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    56. GPIHBP1 and lipolysis: an update. Curr Opin Lipidol. 2009 Jun; 20(3):211-6. Beigneux AP, Weinstein MM, Davies BS, Gin P, Bensadoun A, Fong LG, Young SG. PMID: 19369870.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    57. Chylomicronemia with a mutant GPIHBP1 (Q115P) that cannot bind lipoprotein lipase. Arterioscler Thromb Vasc Biol. 2009 Jun; 29(6):956-62. Beigneux AP, Franssen R, Bensadoun A, Gin P, Melford K, Peter J, Walzem RL, Weinstein MM, Davies BS, Kuivenhoven JA, Kastelein JJ, Fong LG, Dallinga-Thie GM, Young SG. PMID: 19304573.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    58. GPIHBP1, a GPI-anchored protein required for the lipolytic processing of triglyceride-rich lipoproteins. J Lipid Res. 2009 Apr; 50 Suppl:S57-62. Beigneux AP, Davies BS, Bensadoun A, Fong LG, Young SG. PMID: 18854402.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    59. Abnormal patterns of lipoprotein lipase release into the plasma in GPIHBP1-deficient mice. J Biol Chem. 2008 Dec 12; 283(50):34511-8. Weinstein MM, Yin L, Beigneux AP, Davies BS, Gin P, Estrada K, Melford K, Bishop JR, Esko JD, Dallinga-Thie GM, Fong LG, Bensadoun A, Young SG. PMID: 18845532.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    60. The expression of GPIHBP1, an endothelial cell binding site for lipoprotein lipase and chylomicrons, is induced by peroxisome proliferator-activated receptor-gamma. Mol Endocrinol. 2008 Nov; 22(11):2496-504. Davies BS, Waki H, Beigneux AP, Farber E, Weinstein MM, Wilpitz DC, Tai LJ, Evans RM, Fong LG, Tontonoz P, Young SG. PMID: 18787041.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    61. The acidic domain of GPIHBP1 is important for the binding of lipoprotein lipase and chylomicrons. J Biol Chem. 2008 Oct 24; 283(43):29554-62. Gin P, Yin L, Davies BS, Weinstein MM, Ryan RO, Bensadoun A, Fong LG, Young SG, Beigneux AP. PMID: 18713736.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    62. Glycosylation of Asn-76 in mouse GPIHBP1 is critical for its appearance on the cell surface and the binding of chylomicrons and lipoprotein lipase. J Lipid Res. 2008 Jun; 49(6):1312-21. Beigneux AP, Gin P, Davies BS, Weinstein MM, Bensadoun A, Ryan RO, Fong LG, Young SG. PMID: 18340083.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    63. Lipoprotein size and susceptibility to atherosclerosis--insights from genetically modified mouse models. Curr Drug Targets. 2008 Mar; 9(3):174-89. Véniant MM, Beigneux AP, Bensadoun A, Fong LG, Young SG. PMID: 18336235.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    64. AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase. J Biol Chem. 2008 Apr 11; 283(15):10048-57. Chen YQ, Kuo MS, Li S, Bui HH, Peake DA, Sanders PE, Thibodeaux SJ, Chu S, Qian YW, Zhao Y, Bredt DS, Moller DE, Konrad RJ, Beigneux AP, Young SG, Cao G. PMID: 18238778.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    65. Normal binding of lipoprotein lipase, chylomicrons, and apo-AV to GPIHBP1 containing a G56R amino acid substitution. Biochim Biophys Acta. 2007 Dec; 1771(12):1464-8. Gin P, Beigneux AP, Davies B, Young MF, Ryan RO, Bensadoun A, Fong LG, Young SG. PMID: 17997385.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    66. ESCRT-III dysfunction causes autophagosome accumulation and neurodegeneration. Curr Biol. 2007 Sep 18; 17(18):1561-7. Lee JA, Beigneux A, Ahmad ST, Young SG, Gao FB. PMID: 17683935.
      View in: PubMed   Mentions: 200     Fields:    Translation:HumansAnimalsCells
    67. GPIHBP1: an endothelial cell molecule important for the lipolytic processing of chylomicrons. Curr Opin Lipidol. 2007 Aug; 18(4):389-96. Young SG, Davies BS, Fong LG, Gin P, Weinstein MM, Bensadoun A, Beigneux AP. PMID: 17620854.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    68. Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons. Cell Metab. 2007 Apr; 5(4):279-91. Beigneux AP, Davies BS, Gin P, Weinstein MM, Farber E, Qiao X, Peale F, Bunting S, Walzem RL, Wong JS, Blaner WS, Ding ZM, Melford K, Wongsiriroj N, Shu X, de Sauvage F, Ryan RO, Fong LG, Bensadoun A, Young SG. PMID: 17403372.
      View in: PubMed   Mentions: 174     Fields:    Translation:AnimalsCells
    69. Behavioural alterations in male mice lacking the gene for D-aspartate oxidase. Behav Brain Res. 2006 Aug 10; 171(2):295-302. Weil ZM, Huang AS, Beigneux A, Kim PM, Molliver ME, Blackshaw S, Young SG, Nelson RJ, Snyder SH. PMID: 16725213.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    70. D-aspartate regulates melanocortin formation and function: behavioral alterations in D-aspartate oxidase-deficient mice. J Neurosci. 2006 Mar 08; 26(10):2814-9. Huang AS, Beigneux A, Weil ZM, Kim PM, Molliver ME, Blackshaw S, Nelson RJ, Young SG, Snyder SH. PMID: 16525061.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    71. Agpat6--a novel lipid biosynthetic gene required for triacylglycerol production in mammary epithelium. J Lipid Res. 2006 Apr; 47(4):734-44. Beigneux AP, Vergnes L, Qiao X, Quatela S, Davis R, Watkins SM, Coleman RA, Walzem RL, Philips M, Reue K, Young SG. PMID: 16449762.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    72. Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity. J Lipid Res. 2006 Apr; 47(4):745-54. Vergnes L, Beigneux AP, Davis R, Watkins SM, Young SG, Reue K. PMID: 16436371.
      View in: PubMed   Mentions: 56     Fields:    Translation:Animals
    73. Disruption of the phosphatidylserine decarboxylase gene in mice causes embryonic lethality and mitochondrial defects. J Biol Chem. 2005 Dec 02; 280(48):40032-40. Steenbergen R, Nanowski TS, Beigneux A, Kulinski A, Young SG, Vance JE. PMID: 16192276.
      View in: PubMed   Mentions: 82     Fields:    Translation:AnimalsCells
    74. Blocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes. Proc Natl Acad Sci U S A. 2005 Sep 06; 102(36):12873-8. Toth JI, Yang SH, Qiao X, Beigneux AP, Gelb MH, Moulson CL, Miner JH, Young SG, Fong LG. PMID: 16129834.
      View in: PubMed   Mentions: 118     Fields:    Translation:HumansAnimalsCells
    75. Assembly of lipoprotein particles containing apolipoprotein-B: structural model for the nascent lipoprotein particle. Biophys J. 2005 Apr; 88(4):2789-800. Richardson PE, Manchekar M, Dashti N, Jones MK, Beigneux A, Young SG, Harvey SC, Segrest JP. PMID: 15653747.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    76. Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf. J Clin Invest. 2004 Feb; 113(4):539-50. Bergo MO, Gavino BJ, Hong C, Beigneux AP, McMahon M, Casey PJ, Young SG. PMID: 14966563.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    77. ATP-citrate lyase deficiency in the mouse. J Biol Chem. 2004 Mar 05; 279(10):9557-64. Beigneux AP, Kosinski C, Gavino B, Horton JD, Skarnes WC, Young SG. PMID: 14662765.
      View in: PubMed   Mentions: 50     Fields:    Translation:Animals
    78. Sick euthyroid syndrome is associated with decreased TR expression and DNA binding in mouse liver. Am J Physiol Endocrinol Metab. 2003 Jan; 284(1):E228-36. Beigneux AP, Moser AH, Shigenaga JK, Grunfeld C, Feingold KR. PMID: 12388159.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    79. Prenylcysteine lyase deficiency in mice results in the accumulation of farnesylcysteine and geranylgeranylcysteine in brain and liver. J Biol Chem. 2002 Oct 11; 277(41):38358-63. Beigneux A, Withycombe SK, Digits JA, Tschantz WR, Weinbaum CA, Griffey SM, Bergo M, Casey PJ, Young SG. PMID: 12151402.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    80. Human CYP7A1 deficiency: progress and enigmas. J Clin Invest. 2002 Jul; 110(1):29-31. Beigneux A, Hofmann AF, Young SG. PMID: 12093884.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    81. Reduction in cytochrome P-450 enzyme expression is associated with repression of CAR (constitutive androstane receptor) and PXR (pregnane X receptor) in mouse liver during the acute phase response. Biochem Biophys Res Commun. 2002 Apr 26; 293(1):145-9. Beigneux AP, Moser AH, Shigenaga JK, Grunfeld C, Feingold KR. PMID: 12054576.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    82. Blocking the secretion of hepatic very low density lipoproteins renders the liver more susceptible to toxin-induced injury. J Biol Chem. 2002 Feb 15; 277(7):5476-83. Björkegren J, Beigneux A, Bergo MO, Maher JJ, Young SG. PMID: 11739387.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    83. Up-regulation of peroxisome proliferator-activated receptors (PPAR-alpha) and PPAR-gamma messenger ribonucleic acid expression in the liver in murine obesity: troglitazone induces expression of PPAR-gamma-responsive adipose tissue-specific genes in the liver of obese diabetic mice. Endocrinology. 2000 Nov; 141(11):4021-31. Memon RA, Tecott LH, Nonogaki K, Beigneux A, Moser AH, Grunfeld C, Feingold KR. PMID: 11089532.
      View in: PubMed   Mentions: 96     Fields:    Translation:Animals
    84. The acute phase response is associated with retinoid X receptor repression in rodent liver. J Biol Chem. 2000 May 26; 275(21):16390-9. Beigneux AP, Moser AH, Shigenaga JK, Grunfeld C, Feingold KR. PMID: 10747970.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    85. Repression of apoC-III gene expression by TNFalpha involves C/EBPdelta/NF-IL6beta via an IL-1 independent pathway. FEBS Lett. 1997 Sep 29; 415(2):217-20. Lacorte JM, Beigneux A, Parant M, Chambaz J. PMID: 9350999.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    86. Activation of CAAT enhancer-binding protein delta (C/EBPdelta) by interleukin-1 negatively influences apolipoprotein C-III expression. J Biol Chem. 1997 Sep 19; 272(38):23578-84. Lacorte JM, Ktistaki E, Beigneux A, Zannis VI, Chambaz J, Talianidis I. PMID: 9295296.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    87. Regulation of lipopolysaccharide-induced tumor necrosis factor production by cyclosporin A in mice primed with muramyl dipeptide. FEMS Immunol Med Microbiol. 1995 Jul; 11(4):297-305. Le Contel C, Beigneux AP, Huang J, Parant MA. PMID: 8541808.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    88. Differential role of interferon-gamma in the potentiating effect of muramyl peptides for enhanced responses to lipopolysaccharide in mice: effect of cyclosporin A. J Interferon Cytokine Res. 1995 Apr; 15(4):359-65. Beigneux A, Huang J, Le Contel C, Heremans H, Parant MA. PMID: 7627811.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
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