Loren G Fong
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Title(s) | Professor-in-Residence, Medicine |
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School | Medicine |
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Address | 760 Westwood Plaza 32-144 Los Angeles CA 90024
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Phone | 54997 |
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vCard | Download vCard |
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Research Bibliographic
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High-resolution visualization and quantification of nucleic acid-based therapeutics in cells and tissues using Nanoscale secondary ion mass spectrometry (NanoSIMS). Nucleic Acids Res. 2020 Dec 04.
He C, Migawa MT, Chen K, Weston TA, Tanowitz M, Song W, Guagliardo P, Iyer KS, Bennett CF, Fong LG, Seth PP, Young SG, Jiang H. PMID: 33275144.
View in: PubMed Mentions: Fields: Translation: HumansAnimalsCells
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Nuclear membrane ruptures, cell death, and tissue damage in the setting of nuclear lamin deficiencies. Nucleus. 2020 12; 11(1):237-249.
Chen NY, Kim PH, Fong LG, Young SG. PMID: 32910721.
View in: PubMed Mentions: Fields:
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Chylomicronemia from GPIHBP1 autoantibodies. J Lipid Res. 2020 Nov; 61(11):1365-1376.
Miyashita K, Lutz J, Hudgins LC, Toib D, Ashraf AP, Song W, Murakami M, Nakajima K, Ploug M, Fong LG, Young SG, Beigneux AP. PMID: 32948662.
View in: PubMed Mentions: Fields:
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Chylomicronemia From GPIHBP1 Autoantibodies Successfully Treated With Rituximab: A Case Report. Ann Intern Med. 2020 11 03; 173(9):764-765.
Lutz J, Dunaj-Kazmierowska M, Arcan S, Kassner U, Miyashita K, Murakami M, Ploug M, Fong LG, Young SG, Nakajima K, Beigneux AP. PMID: 32777186.
View in: PubMed Mentions: 1 Fields:
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The structural basis for monoclonal antibody 5D2 binding to the tryptophan-rich loop of lipoprotein lipase. J Lipid Res. 2020 Oct; 61(10):1347-1359.
Luz JG, Beigneux AP, Asamoto DK, He C, Song W, Allan CM, Morales J, Tu Y, Kwok A, Cottle T, Meiyappan M, Fong LG, Kim JE, Ploug M, Young SG, Birrane G. PMID: 32690595.
View in: PubMed Mentions: 1 Fields:
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Peroxidasin-mediated bromine enrichment of basement membranes. Proc Natl Acad Sci U S A. 2020 07 07; 117(27):15827-15836.
He C, Song W, Weston TA, Tran C, Kurtz I, Zuckerman JE, Guagliardo P, Miner JH, Ivanov SV, Bougoure J, Hudson BG, Colon S, Voziyan PA, Bhave G, Fong LG, Young SG, Jiang H. PMID: 32571911.
View in: PubMed Mentions: 1 Fields: Translation: HumansAnimalsCells
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Cultured macrophages transfer surplus cholesterol into adjacent cells in the absence of serum or high-density lipoproteins. Proc Natl Acad Sci U S A. 2020 05 12; 117(19):10476-10483.
He C, Jiang H, Song W, Riezman H, Tontonoz P, Weston TA, Guagliardo P, Kim PH, Jung R, Heizer P, Fong LG, Young SG. PMID: 32354992.
View in: PubMed Mentions: 1 Fields: Translation: AnimalsCells
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The fatty acids from LPL-mediated processing of triglyceride-rich lipoproteins are taken up rapidly by cardiomyocytes. J Lipid Res. 2020 06; 61(6):815.
Jiang H, He C, Fong LG, Young SG. PMID: 32241805.
View in: PubMed Mentions: Fields:
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GPIHBP1, a partner protein for lipoprotein lipase, is expressed only in capillary endothelial cells. J Lipid Res. 2020 05; 61(5):591.
Meng X, Zeng W, Young SG, Fong LG. PMID: 32132144.
View in: PubMed Mentions: 2 Fields:
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Intermittent chylomicronemia caused by intermittent GPIHBP1 autoantibodies. J Clin Lipidol. 2020 Mar - Apr; 14(2):197-200.
Ashraf AP, Miyashita K, Nakajima K, Murakami M, Hegele RA, Ploug M, Fong LG, Young SG, Beigneux AP. PMID: 32107180.
View in: PubMed Mentions: 2 Fields:
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Deficiency in ZMPSTE24 and resulting farnesyl-prelamin A accumulation only modestly affect mouse adipose tissue stores. J Lipid Res. 2020 03; 61(3):413-421.
Heizer PJ, Yang Y, Tu Y, Kim PH, Chen NY, Hu Y, Yoshinaga Y, de Jong PJ, Vergnes L, Morales JE, Li RL, Jackson N, Reue K, Young SG, Fong LG. PMID: 31941672.
View in: PubMed Mentions: Fields:
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An absence of lamin B1 in migrating neurons causes nuclear membrane ruptures and cell death. Proc Natl Acad Sci U S A. 2019 12 17; 116(51):25870-25879.
Chen NY, Yang Y, Weston TA, Belling JN, Heizer P, Tu Y, Kim P, Edillo L, Jonas SJ, Weiss PS, Fong LG, Young SG. PMID: 31796586.
View in: PubMed Mentions: 6 Fields: Translation: AnimalsCells
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Release of cholesterol-rich particles from the macrophage plasma membrane during movement of filopodia and lamellipodia. Elife. 2019 09 05; 8.
Hu X, Weston TA, He C, Jung RS, Heizer PJ, Young BD, Tu Y, Tontonoz P, Wohlschlegel JA, Jiang H, Young SG, Fong LG. PMID: 31486771.
View in: PubMed Mentions: 5 Fields: Translation: AnimalsCells
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GPIHBP1 and Lipoprotein Lipase, Partners in Plasma Triglyceride Metabolism. Cell Metab. 2019 07 02; 30(1):51-65.
Young SG, Fong LG, Beigneux AP, Allan CM, He C, Jiang H, Nakajima K, Meiyappan M, Birrane G, Ploug M. PMID: 31269429.
View in: PubMed Mentions: 12 Fields: Translation: HumansAnimalsCells
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DYT1 Dystonia Patient-Derived Fibroblasts Have Increased Deformability and Susceptibility to Damage by Mechanical Forces. Front Cell Dev Biol. 2019; 7:103.
Gill NK, Ly C, Kim PH, Saunders CA, Fong LG, Young SG, Luxton GWG, Rowat AC. PMID: 31294022.
View in: PubMed Mentions:
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GPIHBP1 expression in gliomas promotes utilization of lipoprotein-derived nutrients. Elife. 2019 06 06; 8.
Hu X, Matsumoto K, Jung RS, Weston TA, Heizer PJ, He C, Sandoval NP, Allan CM, Tu Y, Vinters HV, Liau LM, Ellison RM, Morales JE, Baufeld LJ, Bayley NA, He L, Betsholtz C, Beigneux AP, Nathanson DA, Gerhardt H, Young SG, Fong LG, Jiang H. PMID: 31169500.
View in: PubMed Mentions: 1 Fields: Translation: HumansAnimalsCells
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Lipoprotein lipase is active as a monomer. Proc Natl Acad Sci U S A. 2019 03 26; 116(13):6319-6328.
Beigneux AP, Allan CM, Sandoval NP, Cho GW, Heizer PJ, Jung RS, Stanhope KL, Havel PJ, Birrane G, Meiyappan M, Gill JE, Murakami M, Miyashita K, Nakajima K, Ploug M, Fong LG, Young SG. PMID: 30850549.
View in: PubMed Mentions: 15 Fields: Translation: HumansAnimalsCells
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An upstream enhancer regulates Gpihbp1 expression in a tissue-specific manner. J Lipid Res. 2019 04; 60(4):869-879.
Allan CM, Heizer PJ, Tu Y, Sandoval NP, Jung RS, Morales JE, Sajti E, Troutman TD, Saunders TL, Cusanovich DA, Beigneux AP, Romanoski CE, Fong LG, Young SG. PMID: 30598475.
View in: PubMed Mentions: 2 Fields: Translation: HumansAnimalsCells
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Structure of the lipoprotein lipase-GPIHBP1 complex that mediates plasma triglyceride hydrolysis. Proc Natl Acad Sci U S A. 2019 01 29; 116(5):1723-1732.
Birrane G, Beigneux AP, Dwyer B, Strack-Logue B, Kristensen KK, Francone OL, Fong LG, Mertens HDT, Pan CQ, Ploug M, Young SG, Meiyappan M. PMID: 30559189.
View in: PubMed Mentions: 21 Fields: Translation: HumansAnimalsCells
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Lipin 2/3 phosphatidic acid phosphatases maintain phospholipid homeostasis to regulate chylomicron synthesis. J Clin Invest. 2019 01 02; 129(1):281-295.
Zhang P, Csaki LS, Ronquillo E, Baufeld LJ, Lin JY, Gutierrez A, Dwyer JR, Brindley DN, Fong LG, Tontonoz P, Young SG, Reue K. PMID: 30507612.
View in: PubMed Mentions: 5 Fields: Translation: AnimalsCells
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Prelamin A causes aberrant myonuclear arrangement and results in muscle fiber weakness. JCI Insight. 2018 10 04; 3(19).
Levy Y, Ross JA, Niglas M, Snetkov VA, Lynham S, Liao CY, Puckelwartz MJ, Hsu YM, McNally EM, Alsheimer M, Harridge SD, Young SG, Fong LG, Español Y, Lopez-Otin C, Kennedy BK, Lowe DA, Ochala J. PMID: 30282816.
View in: PubMed Mentions: 6 Fields: Translation: HumansAnimalsCells
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Disrupting the LINC complex in smooth muscle cells reduces aortic disease in a mouse model of Hutchinson-Gilford progeria syndrome. Sci Transl Med. 2018 09 26; 10(460).
Kim PH, Luu J, Heizer P, Tu Y, Weston TA, Chen N, Lim C, Li RL, Lin PY, Dunn JCY, Hodzic D, Young SG, Fong LG. PMID: 30257952.
View in: PubMed Mentions: 16 Fields: Translation: AnimalsCells
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Fibroblasts lacking nuclear lamins do not have nuclear blebs or protrusions but nevertheless have frequent nuclear membrane ruptures. Proc Natl Acad Sci U S A. 2018 10 02; 115(40):10100-10105.
Chen NY, Kim P, Weston TA, Edillo L, Tu Y, Fong LG, Young SG. PMID: 30224463.
View in: PubMed Mentions: 13 Fields: Translation: AnimalsCells
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NanoSIMS imaging reveals unexpected heterogeneity in nutrient uptake by brown adipocytes. Biochem Biophys Res Commun. 2018 10 12; 504(4):899-902.
He C, Hu X, Weston TA, Jung RS, Heizer P, Tu Y, Ellison R, Matsumoto K, Gerhardt H, Tontonoz P, Fong LG, Young SG, Jiang H. PMID: 30224066.
View in: PubMed Mentions: 1 Fields: Translation: AnimalsCells
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Macrophages release plasma membrane-derived particles rich in accessible cholesterol. Proc Natl Acad Sci U S A. 2018 09 04; 115(36):E8499-E8508.
He C, Hu X, Weston TA, Jung RS, Sandhu J, Huang S, Heizer P, Kim J, Ellison R, Xu J, Kilburn M, Bensinger SJ, Riezman H, Tontonoz P, Fong LG, Jiang H, Young SG. PMID: 30127022.
View in: PubMed Mentions: 7 Fields: Translation: AnimalsCells
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A disordered acidic domain in GPIHBP1 harboring a sulfated tyrosine regulates lipoprotein lipase. Proc Natl Acad Sci U S A. 2018 06 26; 115(26):E6020-E6029.
PMID: 29899144.
View in: PubMed Mentions: 13 Fields: Translation: HumansAnimalsCells
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NanoSIMS Analysis of Intravascular Lipolysis and Lipid Movement across Capillaries and into Cardiomyocytes. Cell Metab. 2018 May 01; 27(5):1055-1066.e3.
He C, Weston TA, Jung RS, Heizer P, Larsson M, Hu X, Allan CM, Tontonoz P, Reue K, Beigneux AP, Ploug M, Holme A, Kilburn M, Guagliardo P, Ford DA, Fong LG, Young SG, Jiang H. PMID: 29719224.
View in: PubMed Mentions: 14 Fields: Translation: AnimalsCells
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Impaired thermogenesis and sharp increases in plasma triglyceride levels in GPIHBP1-deficient mice during cold exposure. J Lipid Res. 2018 04; 59(4):706-713.
Larsson M, Allan CM, Heizer PJ, Tu Y, Sandoval NP, Jung RS, Walzem RL, Beigneux AP, Young SG, Fong LG. PMID: 29449313.
View in: PubMed Mentions: 1 Fields: Translation: Animals
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IL-10 Signaling Remodels Adipose Chromatin Architecture to Limit Thermogenesis and Energy Expenditure. Cell. 2018 01 11; 172(1-2):218-233.e17.
PMID: 29249357.
View in: PubMed Mentions: 17 Fields: Translation: AnimalsCells
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Lipoprotein lipase reaches the capillary lumen in chickens despite an apparent absence of GPIHBP1. JCI Insight. 2017 10 19; 2(20).
He C, Hu X, Jung RS, Larsson M, Tu Y, Duarte-Vogel S, Kim P, Sandoval NP, Price TR, Allan CM, Raney B, Jiang H, Bensadoun A, Walzem RL, Kuo RI, Beigneux AP, Fong LG, Young SG. PMID: 29046479.
View in: PubMed Mentions: 2 Fields: Translation: HumansAnimalsCells
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Palmoplantar keratoderma in Slurp1/Slurp2 double-knockout mice. J Dermatol Sci. 2018 Jan; 89(1):85-87.
Allan CM, Heizer PJ, Jung CJ, Tu Y, Tran D, Young LC, Fong LG, de Jong PJ, Beigneux AP, Young SG. PMID: 29017797.
View in: PubMed Mentions: 1 Fields: Translation: HumansAnimals
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A hypomorphic Egfr allele does not ameliorate the palmoplantar keratoderma caused by SLURP1 deficiency. Exp Dermatol. 2017 11; 26(11):1134-1136.
PMID: 28418591.
View in: PubMed Mentions: Fields: Translation: AnimalsCells
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Apolipoprotein C-III inhibits triglyceride hydrolysis by GPIHBP1-bound LPL. J Lipid Res. 2017 09; 58(9):1893-1902.
Larsson M, Allan CM, Jung RS, Heizer PJ, Beigneux AP, Young SG, Fong LG. PMID: 28694296.
View in: PubMed Mentions: 9 Fields: Translation: HumansAnimalsCells
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GPIHBP1 autoantibodies in a patient with unexplained chylomicronemia. J Clin Lipidol. 2017 Jul - Aug; 11(4):964-971.
Hu X, Dallinga-Thie GM, Hovingh GK, Chang SY, Sandoval NP, Dang TLP, Fukamachi I, Miyashita K, Nakajima K, Murakami M, Fong LG, Ploug M, Young SG, Beigneux AP. PMID: 28666713.
View in: PubMed Mentions: 8 Fields: Translation: HumansAnimalsCells
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Mutating a conserved cysteine in GPIHBP1 reduces amounts of GPIHBP1 in capillaries and abolishes LPL binding. J Lipid Res. 2017 07; 58(7):1453-1461.
PMID: 28476858.
View in: PubMed Mentions: 5 Fields: Translation: HumansAnimalsCells
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Autoantibodies against GPIHBP1 as a Cause of Hypertriglyceridemia. N Engl J Med. 2017 04 27; 376(17):1647-1658.
PMID: 28402248.
View in: PubMed Mentions: 18 Fields: Translation: HumansCells
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High-resolution imaging and quantification of plasma membrane cholesterol by NanoSIMS. Proc Natl Acad Sci U S A. 2017 02 21; 114(8):2000-2005.
PMID: 28167768.
View in: PubMed Mentions: 16 Fields: Translation: AnimalsCells
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Monoclonal antibodies that bind to the Ly6 domain of GPIHBP1 abolish the binding of LPL. J Lipid Res. 2017 01; 58(1):208-215.
PMID: 27875259.
View in: PubMed Mentions: 8 Fields: Translation: HumansAnimalsCells
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Mobility of "HSPG-bound" LPL explains how LPL is able to reach GPIHBP1 on capillaries. J Lipid Res. 2017 01; 58(1):216-225.
PMID: 27811232.
View in: PubMed Mentions: 10 Fields: Translation: HumansAnimalsCells
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NanoSIMS imaging: an approach for visualizing and quantifying lipids in cells and tissues. J Investig Med. 2017 03; 65(3):669-672.
PMID: 27793974.
View in: PubMed Mentions: 6 Fields: Translation: HumansAnimalsCells
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LMNA missense mutations causing familial partial lipodystrophy do not lead to an accumulation of prelamin A. Nucleus. 2016 Sep 02; 7(5):512-521.
PMID: 27841971.
View in: PubMed Mentions: 2 Fields: Translation: HumansCells
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An LPL-specific monoclonal antibody, 88B8, that abolishes the binding of LPL to GPIHBP1. J Lipid Res. 2016 10; 57(10):1889-1898.
PMID: 27494936.
View in: PubMed Mentions: 3 Fields: Translation: HumansAnimalsCells
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GPIHBP1 and Plasma Triglyceride Metabolism. Trends Endocrinol Metab. 2016 07; 27(7):455-469.
PMID: 27185325.
View in: PubMed Mentions: 21 Fields: Translation: HumansAnimals
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Lamin B1 and lamin B2 are long-lived proteins with distinct functions in retinal development. Mol Biol Cell. 2016 06 15; 27(12):1928-37.
PMID: 27075175.
View in: PubMed Mentions: 9 Fields: Translation: AnimalsCells
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Modulation of LMNA splicing as a strategy to treat prelamin A diseases. J Clin Invest. 2016 Apr 01; 126(4):1592-602.
PMID: 26999604.
View in: PubMed Mentions: 28 Fields: Translation: HumansAnimalsCells
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The acidic domain of the endothelial membrane protein GPIHBP1 stabilizes lipoprotein lipase activity by preventing unfolding of its catalytic domain. Elife. 2016 Jan 03; 5:e12095.
PMID: 26725083.
View in: PubMed Mentions: 35 Fields: Translation: HumansAnimalsCells
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SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression. J Lipid Res. 2016 Mar; 57(3):410-21.
PMID: 26685326.
View in: PubMed Mentions: 14 Fields: Translation: AnimalsCells
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Palmoplantar Keratoderma in Slurp2-Deficient Mice. J Invest Dermatol. 2016 Feb; 136(2):436-443.
PMID: 26967477.
View in: PubMed Mentions: 8 Fields: Translation: AnimalsCells
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Nuclear envelope protein Lem2 is required for mouse development and regulates MAP and AKT kinases. PLoS One. 2015; 10(3):e0116196.
PMID: 25790465.
View in: PubMed Mentions: 11 Fields: Translation: AnimalsCells
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Mice that express farnesylated versions of prelamin A in neurons develop achalasia. Hum Mol Genet. 2015 May 15; 24(10):2826-40.
PMID: 25652409.
View in: PubMed Mentions: 3 Fields: Translation: AnimalsCells
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GPIHBP1 missense mutations often cause multimerization of GPIHBP1 and thereby prevent lipoprotein lipase binding. Circ Res. 2015 Feb 13; 116(4):624-32.
PMID: 25387803.
View in: PubMed Mentions: 24 Fields: Translation: HumansAnimalsCells
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The LXR-Idol axis differentially regulates plasma LDL levels in primates and mice. Cell Metab. 2014 Nov 04; 20(5):910-918.
PMID: 25440061.
View in: PubMed Mentions: 22 Fields: Translation: HumansAnimalsCells
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Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs. J Clin Invest. 2014 Dec; 124(12):5368-84.
PMID: 25347472.
View in: PubMed Mentions: 49 Fields: Translation: HumansAnimalsCells
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An absence of nuclear lamins in keratinocytes leads to ichthyosis, defective epidermal barrier function, and intrusion of nuclear membranes and endoplasmic reticulum into the nuclear chromatin. Mol Cell Biol. 2014 Dec; 34(24):4534-44.
PMID: 25312645.
View in: PubMed Mentions: 10 Fields: Translation: AnimalsCells
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High-resolution imaging of dietary lipids in cells and tissues by NanoSIMS analysis. J Lipid Res. 2014 Oct; 55(10):2156-66.
PMID: 25143463.
View in: PubMed Mentions: 14 Fields: Translation: AnimalsCells
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Do lamin B1 and lamin B2 have redundant functions? Nucleus. 2014 Jul-Aug; 5(4):287-92.
PMID: 25482116.
View in: PubMed Mentions: 3 Fields: Translation: AnimalsCells
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Multimerization of glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) and familial chylomicronemia from a serine-to-cysteine substitution in GPIHBP1 Ly6 domain. J Biol Chem. 2014 Jul 11; 289(28):19491-9.
PMID: 24847059.
View in: PubMed Mentions: 22 Fields: Translation: HumansCellsCTClinical Trials
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Nuclear lamins and neurobiology. Mol Cell Biol. 2014 Aug; 34(15):2776-85.
PMID: 24842906.
View in: PubMed Mentions: 17 Fields: Translation: HumansAnimalsCells
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The GPIHBP1-LPL complex is responsible for the margination of triglyceride-rich lipoproteins in capillaries. Cell Metab. 2014 May 06; 19(5):849-60.
PMID: 24726386.
View in: PubMed Mentions: 54 Fields: Translation: AnimalsCells
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Equivalent binding of wild-type lipoprotein lipase (LPL) and S447X-LPL to GPIHBP1, the endothelial cell LPL transporter. Biochim Biophys Acta. 2014 Jul; 1841(7):963-9.
PMID: 24704550.
View in: PubMed Mentions: 4 Fields: Translation: HumansAnimalsCells
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A new monoclonal antibody, 4-1a, that binds to the amino terminus of human lipoprotein lipase. Biochim Biophys Acta. 2014 Jul; 1841(7):970-6.
PMID: 24681165.
View in: PubMed Mentions: 4 Fields: Translation: HumansAnimalsCells
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Reciprocal knock-in mice to investigate the functional redundancy of lamin B1 and lamin B2. Mol Biol Cell. 2014 May; 25(10):1666-75.
PMID: 24672053.
View in: PubMed Mentions: 15 Fields: Translation: AnimalsCells
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Palmoplantar keratoderma along with neuromuscular and metabolic phenotypes in Slurp1-deficient mice. J Invest Dermatol. 2014 Jun; 134(6):1589-1598.
PMID: 24499735.
View in: PubMed Mentions: 15 Fields: Translation: Animals
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Lipin-1 and lipin-3 together determine adiposity in vivo. Mol Metab. 2014 Apr; 3(2):145-54.
PMID: 24634820.
View in: PubMed Mentions: 17 Fields:
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New Lmna knock-in mice provide a molecular mechanism for the 'segmental aging' in Hutchinson-Gilford progeria syndrome. Hum Mol Genet. 2014 Mar 15; 23(6):1506-15.
PMID: 24203701.
View in: PubMed Mentions: 8 Fields: Translation: Animals
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Targeting isoprenylcysteine methylation ameliorates disease in a mouse model of progeria. Science. 2013 Jun 14; 340(6138):1330-3.
PMID: 23686339.
View in: PubMed Mentions: 33 Fields: Translation: HumansAnimalsCells
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Farnesylation of lamin B1 is important for retention of nuclear chromatin during neuronal migration. Proc Natl Acad Sci U S A. 2013 May 21; 110(21):E1923-32.
PMID: 23650370.
View in: PubMed Mentions: 34 Fields: Translation: AnimalsCells
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Lipins, lipinopathies, and the modulation of cellular lipid storage and signaling. Prog Lipid Res. 2013 Jul; 52(3):305-16.
PMID: 23603613.
View in: PubMed Mentions: 43 Fields: Translation: HumansAnimalsCells
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Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPAR? specifies lipid storage versus thermogenic gene programs. Cell Metab. 2013 Mar 05; 17(3):423-35.
PMID: 23473036.
View in: PubMed Mentions: 55 Fields: Translation: AnimalsCells
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Targeting protein prenylation in progeria. Sci Transl Med. 2013 Feb 06; 5(171):171ps3.
PMID: 23390246.
View in: PubMed Mentions: 14 Fields: Translation: HumansAnimalsCells
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IDOL stimulates clathrin-independent endocytosis and multivesicular body-mediated lysosomal degradation of the low-density lipoprotein receptor. Mol Cell Biol. 2013 Apr; 33(8):1503-14.
PMID: 23382078.
View in: PubMed Mentions: 26 Fields: Translation: HumansAnimalsCells
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Compromised mitochondrial fatty acid synthesis in transgenic mice results in defective protein lipoylation and energy disequilibrium. PLoS One. 2012; 7(10):e47196.
PMID: 23077570.
View in: PubMed Mentions: 24 Fields: Translation: AnimalsCells
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Nuclear lamins in the brain - new insights into function and regulation. Mol Neurobiol. 2013 Feb; 47(1):290-301.
PMID: 23065386.
View in: PubMed Mentions: 14 Fields: Translation: HumansAnimalsCells
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Assessing mechanisms of GPIHBP1 and lipoprotein lipase movement across endothelial cells. J Lipid Res. 2012 Dec; 53(12):2690-7.
PMID: 23008484.
View in: PubMed Mentions: 25 Fields: Translation: HumansAnimalsCells
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Feedback regulation of cholesterol uptake by the LXR-IDOL-LDLR axis. Arterioscler Thromb Vasc Biol. 2012 Nov; 32(11):2541-6.
PMID: 22936343.
View in: PubMed Mentions: 30 Fields: Translation: HumansAnimalsCells
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Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum. Proc Natl Acad Sci U S A. 2012 Sep 11; 109(37):E2486-95.
PMID: 22908270.
View in: PubMed Mentions: 31 Fields: Translation: Animals
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Sphingosine-1-phosphate lyase expression in embryonic and adult murine tissues. J Lipid Res. 2012 Sep; 53(9):1920-31.
PMID: 22781001.
View in: PubMed Mentions: 14 Fields: Translation: Animals
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Chylomicronemia mutations yield new insights into interactions between lipoprotein lipase and GPIHBP1. Hum Mol Genet. 2012 Jul 01; 21(13):2961-72.
PMID: 22493000.
View in: PubMed Mentions: 12 Fields: Translation: AnimalsCells
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Inhibitors of protein geranylgeranyltransferase-I lead to prelamin A accumulation in cells by inhibiting ZMPSTE24. J Lipid Res. 2012 Jun; 53(6):1176-82.
PMID: 22448028.
View in: PubMed Mentions: 10 Fields: Translation: HumansAnimalsCells
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Lowering plasma cholesterol by raising LDL receptors--revisited. N Engl J Med. 2012 Mar 22; 366(12):1154-5.
PMID: 22435375.
View in: PubMed Mentions: 6 Fields: Translation: Humans
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Understanding the roles of nuclear A- and B-type lamins in brain development. J Biol Chem. 2012 May 11; 287(20):16103-10.
PMID: 22416132.
View in: PubMed Mentions: 23 Fields: Translation: HumansAnimalsCells
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New wrinkles in lipoprotein lipase biology. Curr Opin Lipidol. 2012 Feb; 23(1):35-42.
PMID: 22123668.
View in: PubMed Mentions: 25 Fields: Translation: HumansAnimalsCells
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Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA. Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7):E423-31.
PMID: 22308344.
View in: PubMed Mentions: 75 Fields: Translation: Animals
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Reciprocal metabolic perturbations in the adipose tissue and liver of GPIHBP1-deficient mice. Arterioscler Thromb Vasc Biol. 2012 Feb; 32(2):230-5.
PMID: 22173228.
View in: PubMed Mentions: 21 Fields: Translation: AnimalsCells
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Are B-type lamins essential in all mammalian cells? Nucleus. 2011 Nov-Dec; 2(6):562-9.
PMID: 22127257.
View in: PubMed Mentions: 24 Fields: Translation: HumansAnimalsCells
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Severe hepatocellular disease in mice lacking one or both CaaX prenyltransferases. J Lipid Res. 2012 Jan; 53(1):77-86.
PMID: 22039581.
View in: PubMed Mentions: 8 Fields: Translation: AnimalsCells
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The arrestin domain-containing 3 protein regulates body mass and energy expenditure. Cell Metab. 2011 Nov 02; 14(5):671-83.
PMID: 21982743.
View in: PubMed Mentions: 50 Fields: Translation: HumansAnimalsCells
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Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons. Mol Biol Cell. 2011 Dec; 22(23):4683-93.
Coffinier C, Jung HJ, Nobumori C, Chang S, Tu Y, Barnes RH, Yoshinaga Y, de Jong PJ, Vergnes L, Reue K, Fong LG, Young SG. PMID: 21976703.
View in: PubMed Mentions: 94 Fields: Translation: AnimalsCells
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GPIHBP1, an endothelial cell transporter for lipoprotein lipase. J Lipid Res. 2011 Nov; 52(11):1869-84.
PMID: 21844202.
View in: PubMed Mentions: 32 Fields: Translation: HumansAnimalsCells
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An absence of both lamin B1 and lamin B2 in keratinocytes has no effect on cell proliferation or the development of skin and hair. Hum Mol Genet. 2011 Sep 15; 20(18):3537-44.
PMID: 21659336.
View in: PubMed Mentions: 55 Fields: Translation: HumansAnimalsCells
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Mutations in lipoprotein lipase that block binding to the endothelial cell transporter GPIHBP1. Proc Natl Acad Sci U S A. 2011 May 10; 108(19):7980-4.
Voss CV, Davies BS, Tat S, Gin P, Fong LG, Pelletier C, Mottler CD, Bensadoun A, Beigneux AP, Young SG. PMID: 21518912.
View in: PubMed Mentions: 28 Fields: Translation: HumansAnimalsCells
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Assessing the role of the glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) three-finger domain in binding lipoprotein lipase. J Biol Chem. 2011 Jun 03; 286(22):19735-43.
Beigneux AP, Davies BS, Tat S, Chen J, Gin P, Voss CV, Weinstein MM, Bensadoun A, Pullinger CR, Fong LG, Young SG. PMID: 21478160.
View in: PubMed Mentions: 27 Fields: Translation: HumansAnimalsCells
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Protein farnesylation inhibitors cause donut-shaped cell nuclei attributable to a centrosome separation defect. Proc Natl Acad Sci U S A. 2011 Mar 22; 108(12):4997-5002.
Verstraeten VL, Peckham LA, Olive M, Capell BC, Collins FS, Nabel EG, Young SG, Fong LG, Lammerding J. PMID: 21383178.
View in: PubMed Mentions: 33 Fields: Translation: HumansAnimalsCells
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Targeted disruption of the idol gene alters cellular regulation of the low-density lipoprotein receptor by sterols and liver x receptor agonists. Mol Cell Biol. 2011 May; 31(9):1885-93.
PMID: 21343340.
View in: PubMed Mentions: 24 Fields: Translation: AnimalsCells
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Investigating the purpose of prelamin A processing. Nucleus. 2011 Jan-Feb; 2(1):4-9.
PMID: 21647293.
View in: PubMed Mentions: 24 Fields: Translation: AnimalsCells
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Absence of progeria-like disease phenotypes in knock-in mice expressing a non-farnesylated version of progerin. Hum Mol Genet. 2011 Feb 01; 20(3):436-44.
Yang SH, Chang SY, Ren S, Wang Y, Andres DA, Spielmann HP, Fong LG, Young SG. PMID: 21088111.
View in: PubMed Mentions: 28 Fields: Translation: AnimalsCells
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Deletion of the basement membrane heparan sulfate proteoglycan type XVIII collagen causes hypertriglyceridemia in mice and humans. PLoS One. 2010 Nov 10; 5(11):e13919.
PMID: 21085708.
View in: PubMed Mentions: 18 Fields: Translation: HumansAnimals
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Binding preferences for GPIHBP1, a glycosylphosphatidylinositol-anchored protein of capillary endothelial cells. Arterioscler Thromb Vasc Biol. 2011 Jan; 31(1):176-82.
Gin P, Beigneux AP, Voss C, Davies BS, Beckstead JA, Ryan RO, Bensadoun A, Fong LG, Young SG. PMID: 20966398.
View in: PubMed Mentions: 28 Fields: Translation: HumansAnimalsCells
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Unexpected expression pattern for glycosylphosphatidylinositol-anchored HDL-binding protein 1 (GPIHBP1) in mouse tissues revealed by positron emission tomography scanning. J Biol Chem. 2010 Dec 10; 285(50):39239-48.
Olafsen T, Young SG, Davies BS, Beigneux AP, Kenanova VE, Voss C, Young G, Wong KP, Barnes RH, Tu Y, Weinstein MM, Nobumori C, Huang SC, Goldberg IJ, Bensadoun A, Wu AM, Fong LG. PMID: 20889497.
View in: PubMed Mentions: 21 Fields: Translation: AnimalsCells
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Cholesterol intake modulates plasma triglyceride levels in glycosylphosphatidylinositol HDL-binding protein 1-deficient mice. Arterioscler Thromb Vasc Biol. 2010 Nov; 30(11):2106-13.
Weinstein MM, Tu Y, Beigneux AP, Davies BS, Gin P, Voss C, Walzem RL, Reue K, Tontonoz P, Bensadoun A, Fong LG, Young SG. PMID: 20814015.
View in: PubMed Mentions: 12 Fields: Translation: Animals
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LINCing lamin B2 to neuronal migration: growing evidence for cell-specific roles of B-type lamins. Nucleus. 2010 Sep-Oct; 1(5):407-11.
PMID: 21278813.
View in: PubMed Mentions: 23 Fields: Translation: AnimalsCells
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GPIHBP1 is responsible for the entry of lipoprotein lipase into capillaries. Cell Metab. 2010 Jul 07; 12(1):42-52.
Davies BS, Beigneux AP, Barnes RH, Tu Y, Gin P, Weinstein MM, Nobumori C, Nyrén R, Goldberg I, Olivecrona G, Bensadoun A, Young SG, Fong LG. PMID: 20620994.
View in: PubMed Mentions: 125 Fields: Translation: AnimalsCells
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Direct synthesis of lamin A, bypassing prelamin a processing, causes misshapen nuclei in fibroblasts but no detectable pathology in mice. J Biol Chem. 2010 Jul 02; 285(27):20818-26.
Coffinier C, Jung HJ, Li Z, Nobumori C, Yun UJ, Farber EA, Davies BS, Weinstein MM, Yang SH, Lammerding J, Farahani JN, Bentolila LA, Fong LG, Young SG. PMID: 20439468.
View in: PubMed Mentions: 37 Fields: Translation: AnimalsCells
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An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria. Hum Mol Genet. 2010 Jul 01; 19(13):2682-94.
Davies BS, Barnes RH, Tu Y, Ren S, Andres DA, Spielmann HP, Lammerding J, Wang Y, Young SG, Fong LG. PMID: 20421363.
View in: PubMed Mentions: 45 Fields: Translation: AnimalsCells
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Abnormal development of the cerebral cortex and cerebellum in the setting of lamin B2 deficiency. Proc Natl Acad Sci U S A. 2010 Mar 16; 107(11):5076-81.
Coffinier C, Chang SY, Nobumori C, Tu Y, Farber EA, Toth JI, Fong LG, Young SG. PMID: 20145110.
View in: PubMed Mentions: 90 Fields: Translation: AnimalsCells
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Chylomicronemia with low postheparin lipoprotein lipase levels in the setting of GPIHBP1 defects. Circ Cardiovasc Genet. 2010 Apr; 3(2):169-78.
Franssen R, Young SG, Peelman F, Hertecant J, Sierts JA, Schimmel AW, Bensadoun A, Kastelein JJ, Fong LG, Dallinga-Thie GM, Beigneux AP. PMID: 20124439.
View in: PubMed Mentions: 50 Fields: Translation: HumansAnimalsCells
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Genetic studies on the functional relevance of the protein prenyltransferases in skin keratinocytes. Hum Mol Genet. 2010 Apr 15; 19(8):1603-17.
Lee R, Chang SY, Trinh H, Tu Y, White AC, Davies BS, Bergo MO, Fong LG, Lowry WE, Young SG. PMID: 20106865.
View in: PubMed Mentions: 22 Fields: Translation: AnimalsCells
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Mutation of conserved cysteines in the Ly6 domain of GPIHBP1 in familial chylomicronemia. J Lipid Res. 2010 Jun; 51(6):1535-45.
Olivecrona G, Ehrenborg E, Semb H, Makoveichuk E, Lindberg A, Hayden MR, Gin P, Davies BS, Weinstein MM, Fong LG, Beigneux AP, Young SG, Olivecrona T, Hernell O. PMID: 20026666.
View in: PubMed Mentions: 55 Fields: Translation: HumansAnimalsCells
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Assessing the efficacy of protein farnesyltransferase inhibitors in mouse models of progeria. J Lipid Res. 2010 Feb; 51(2):400-5.
Yang SH, Chang SY, Andres DA, Spielmann HP, Young SG, Fong LG. PMID: 19965595.
View in: PubMed Mentions: 19 Fields: Translation: AnimalsCells
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Chylomicronemia elicits atherosclerosis in mice--brief report. Arterioscler Thromb Vasc Biol. 2010 Jan; 30(1):20-3.
Weinstein MM, Yin L, Tu Y, Wang X, Wu X, Castellani LW, Walzem RL, Lusis AJ, Fong LG, Beigneux AP, Young SG. PMID: 19815815.
View in: PubMed Mentions: 25 Fields: Translation: AnimalsCells
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A novel approach to tag and identify geranylgeranylated proteins. Electrophoresis. 2009 Oct; 30(20):3598-606.
Chan LN, Hart C, Guo L, Nyberg T, Davies BS, Fong LG, Young SG, Agnew BJ, Tamanoi F. PMID: 19784953.
View in: PubMed Mentions: 21 Fields: Translation: HumansAnimalsCells
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Highly conserved cysteines within the Ly6 domain of GPIHBP1 are crucial for the binding of lipoprotein lipase. J Biol Chem. 2009 Oct 30; 284(44):30240-7.
Beigneux AP, Gin P, Davies BS, Weinstein MM, Bensadoun A, Fong LG, Young SG. PMID: 19726683.
View in: PubMed Mentions: 40 Fields: Translation: AnimalsCells
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Laminopathies and the long strange trip from basic cell biology to therapy. J Clin Invest. 2009 Jul; 119(7):1825-36.
Worman HJ, Fong LG, Muchir A, Young SG. PMID: 19587457.
View in: PubMed Mentions: 137 Fields: Translation: HumansAnimalsCells
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Sterol regulatory element binding protein 1a regulates hepatic fatty acid partitioning by activating acetyl coenzyme A carboxylase 2. Mol Cell Biol. 2009 Sep; 29(17):4864-72.
Im SS, Hammond LE, Yousef L, Nugas-Selby C, Shin DJ, Seo YK, Fong LG, Young SG, Osborne TF. PMID: 19564420.
View in: PubMed Mentions: 11 Fields: Translation: AnimalsCells
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GPIHBP1 and lipolysis: an update. Curr Opin Lipidol. 2009 Jun; 20(3):211-6.
Beigneux AP, Weinstein MM, Davies BS, Gin P, Bensadoun A, Fong LG, Young SG. PMID: 19369870.
View in: PubMed Mentions: 12 Fields: Translation: HumansAnimalsCells
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Activating the synthesis of progerin, the mutant prelamin A in Hutchinson-Gilford progeria syndrome, with antisense oligonucleotides. Hum Mol Genet. 2009 Jul 01; 18(13):2462-71.
Fong LG, Vickers TA, Farber EA, Choi C, Yun UJ, Hu Y, Yang SH, Coffinier C, Lee R, Yin L, Davies BS, Andres DA, Spielmann HP, Bennett CF, Young SG. PMID: 19376814.
View in: PubMed Mentions: 13 Fields: Translation: HumansCells
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Chylomicronemia with a mutant GPIHBP1 (Q115P) that cannot bind lipoprotein lipase. Arterioscler Thromb Vasc Biol. 2009 Jun; 29(6):956-62.
Beigneux AP, Franssen R, Bensadoun A, Gin P, Melford K, Peter J, Walzem RL, Weinstein MM, Davies BS, Kuivenhoven JA, Kastelein JJ, Fong LG, Dallinga-Thie GM, Young SG. PMID: 19304573.
View in: PubMed Mentions: 65 Fields: Translation: HumansAnimalsCells
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The posttranslational processing of prelamin A and disease. Annu Rev Genomics Hum Genet. 2009; 10:153-74.
Davies BS, Fong LG, Yang SH, Coffinier C, Young SG. PMID: 19453251.
View in: PubMed Mentions: 56 Fields: Translation: HumansAnimalsCells
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Caution! Analyze transcripts from conditional knockout alleles. Transgenic Res. 2009 Jun; 18(3):483-9.
Yang SH, Bergo MO, Farber E, Qiao X, Fong LG, Young SG. PMID: 19093225.
View in: PubMed Mentions: 11 Fields: Translation: Animals
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GPIHBP1, a GPI-anchored protein required for the lipolytic processing of triglyceride-rich lipoproteins. J Lipid Res. 2009 Apr; 50 Suppl:S57-62.
Beigneux AP, Davies BS, Bensadoun A, Fong LG, Young SG. PMID: 18854402.
View in: PubMed Mentions: 24 Fields: Translation: HumansAnimals
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Abnormal patterns of lipoprotein lipase release into the plasma in GPIHBP1-deficient mice. J Biol Chem. 2008 Dec 12; 283(50):34511-8.
Weinstein MM, Yin L, Beigneux AP, Davies BS, Gin P, Estrada K, Melford K, Bishop JR, Esko JD, Dallinga-Thie GM, Fong LG, Bensadoun A, Young SG. PMID: 18845532.
View in: PubMed Mentions: 47 Fields: Translation: AnimalsCells
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Progerin elicits disease phenotypes of progeria in mice whether or not it is farnesylated. J Clin Invest. 2008 Oct; 118(10):3291-300.
Yang SH, Andres DA, Spielmann HP, Young SG, Fong LG. PMID: 18769635.
View in: PubMed Mentions: 50 Fields: Translation: AnimalsCells
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The expression of GPIHBP1, an endothelial cell binding site for lipoprotein lipase and chylomicrons, is induced by peroxisome proliferator-activated receptor-gamma. Mol Endocrinol. 2008 Nov; 22(11):2496-504.
Davies BS, Waki H, Beigneux AP, Farber E, Weinstein MM, Wilpitz DC, Tai LJ, Evans RM, Fong LG, Tontonoz P, Young SG. PMID: 18787041.
View in: PubMed Mentions: 26 Fields: Translation: AnimalsCells
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Increasing the length of progerin's isoprenyl anchor does not worsen bone disease or survival in mice with Hutchinson-Gilford progeria syndrome. J Lipid Res. 2009 Jan; 50(1):126-34.
Davies BS, Yang SH, Farber E, Lee R, Buck SB, Andres DA, Spielmann HP, Agnew BJ, Tamanoi F, Fong LG, Young SG. PMID: 18757838.
View in: PubMed Mentions: 4 Fields: Translation: AnimalsCells
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The acidic domain of GPIHBP1 is important for the binding of lipoprotein lipase and chylomicrons. J Biol Chem. 2008 Oct 24; 283(43):29554-62.
Gin P, Yin L, Davies BS, Weinstein MM, Ryan RO, Bensadoun A, Fong LG, Young SG, Beigneux AP. PMID: 18713736.
View in: PubMed Mentions: 52 Fields: Translation: HumansAnimalsCells
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HIV-protease inhibitors block the enzymatic activity of purified Ste24p. Biochem Biophys Res Commun. 2008 Sep 19; 374(2):365-8.
Hudon SE, Coffinier C, Michaelis S, Fong LG, Young SG, Hrycyna CA. PMID: 18639527.
View in: PubMed Mentions: 21 Fields: Translation: HumansCells
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PCSK9 function and physiology. J Lipid Res. 2008 Jul; 49(7):1595-9.
Peterson AS, Fong LG, Young SG. PMID: 18663786.
View in: PubMed Mentions: 23 Fields: Translation: HumansCells
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PCSK9 function and physiology. J Lipid Res. 2008 Jun; 49(6):1152-6.
Peterson AS, Fong LG, Young SG. PMID: 18375913.
View in: PubMed Mentions: 11 Fields: Translation: HumansAnimalsCells
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Glycosylation of Asn-76 in mouse GPIHBP1 is critical for its appearance on the cell surface and the binding of chylomicrons and lipoprotein lipase. J Lipid Res. 2008 Jun; 49(6):1312-21.
Beigneux AP, Gin P, Davies BS, Weinstein MM, Bensadoun A, Ryan RO, Fong LG, Young SG. PMID: 18340083.
View in: PubMed Mentions: 19 Fields: Translation: HumansAnimalsCells
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Lipoprotein size and susceptibility to atherosclerosis--insights from genetically modified mouse models. Curr Drug Targets. 2008 Mar; 9(3):174-89.
Véniant MM, Beigneux AP, Bensadoun A, Fong LG, Young SG. PMID: 18336235.
View in: PubMed Mentions: 13 Fields: Translation: HumansAnimals
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A potent HIV protease inhibitor, darunavir, does not inhibit ZMPSTE24 or lead to an accumulation of farnesyl-prelamin A in cells. J Biol Chem. 2008 Apr 11; 283(15):9797-804.
Coffinier C, Hudon SE, Lee R, Farber EA, Nobumori C, Miner JH, Andres DA, Spielmann HP, Hrycyna CA, Fong LG, Young SG. PMID: 18230615.
View in: PubMed Mentions: 23 Fields: Translation: HumansAnimalsCells
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Eliminating the synthesis of mature lamin A reduces disease phenotypes in mice carrying a Hutchinson-Gilford progeria syndrome allele. J Biol Chem. 2008 Mar 14; 283(11):7094-9.
Yang SH, Qiao X, Farber E, Chang SY, Fong LG, Young SG. PMID: 18178963.
View in: PubMed Mentions: 23 Fields: Translation: AnimalsCells
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Genetic analyses of the role of RCE1 in RAS membrane association and transformation. Methods Enzymol. 2008; 438:367-89.
Bergo MO, Wahlstrom AM, Fong LG, Young SG. PMID: 18413262.
View in: PubMed Mentions: 6 Fields: Translation: HumansAnimalsCells
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Treatment with a farnesyltransferase inhibitor improves survival in mice with a Hutchinson-Gilford progeria syndrome mutation. Biochim Biophys Acta. 2008 Jan-Feb; 1781(1-2):36-9.
Yang SH, Qiao X, Fong LG, Young SG. PMID: 18082640.
View in: PubMed Mentions: 36 Fields: Translation: Animals
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Normal binding of lipoprotein lipase, chylomicrons, and apo-AV to GPIHBP1 containing a G56R amino acid substitution. Biochim Biophys Acta. 2007 Dec; 1771(12):1464-8.
Gin P, Beigneux AP, Davies B, Young MF, Ryan RO, Bensadoun A, Fong LG, Young SG. PMID: 17997385.
View in: PubMed Mentions: 21 Fields: Translation: HumansAnimalsCells
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Increased progerin expression associated with unusual LMNA mutations causes severe progeroid syndromes. Hum Mutat. 2007 Sep; 28(9):882-9.
Moulson CL, Fong LG, Gardner JM, Farber EA, Go G, Passariello A, Grange DK, Young SG, Miner JH. PMID: 17469202.
View in: PubMed Mentions: 41 Fields: Translation: HumansCells
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GPIHBP1: an endothelial cell molecule important for the lipolytic processing of chylomicrons. Curr Opin Lipidol. 2007 Aug; 18(4):389-96.
Young SG, Davies BS, Fong LG, Gin P, Weinstein MM, Bensadoun A, Beigneux AP. PMID: 17620854.
View in: PubMed Mentions: 38 Fields: Translation: HumansAnimalsCells
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HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells. Proc Natl Acad Sci U S A. 2007 Aug 14; 104(33):13432-7.
Coffinier C, Hudon SE, Farber EA, Chang SY, Hrycyna CA, Young SG, Fong LG. PMID: 17652517.
View in: PubMed Mentions: 43 Fields: Translation: HumansCells
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Modeling insertional mutagenesis using gene length and expression in murine embryonic stem cells. PLoS One. 2007 Jul 18; 2(7):e617.
Nord AS, Vranizan K, Tingley W, Zambon AC, Hanspers K, Fong LG, Hu Y, Bacchetti P, Ferrin TE, Babbitt PC, Doniger SW, Skarnes WC, Young SG, Conklin BR. PMID: 17637833.
View in: PubMed Mentions: 7 Fields: Translation: AnimalsCells
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10 Genetic approaches to understanding the physiologic importance of the carboxyl methylation of isoprenylated proteins. Enzymes. 2006; 24:273-301.
PMID: 26718044.
View in: PubMed Mentions: Fields:
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Cell nuclei spin in the absence of lamin b1. J Biol Chem. 2007 Jul 06; 282(27):20015-26.
Ji JY, Lee RT, Vergnes L, Fong LG, Stewart CL, Reue K, Young SG, Zhang Q, Shanahan CM, Lammerding J. PMID: 17488709.
View in: PubMed Mentions: 37 Fields: Translation: HumansAnimalsCells
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Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons. Cell Metab. 2007 Apr; 5(4):279-91.
Beigneux AP, Davies BS, Gin P, Weinstein MM, Farber E, Qiao X, Peale F, Bunting S, Walzem RL, Wong JS, Blaner WS, Ding ZM, Melford K, Wongsiriroj N, Shu X, de Sauvage F, Ryan RO, Fong LG, Bensadoun A, Young SG. PMID: 17403372.
View in: PubMed Mentions: 174 Fields: Translation: AnimalsCells
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Mouse models of the laminopathies. Exp Cell Res. 2007 Jun 10; 313(10):2144-56.
Stewart CL, Kozlov S, Fong LG, Young SG. PMID: 17493612.
View in: PubMed Mentions: 52 Fields: Translation: HumansAnimalsCells
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Prelamin A farnesylation and progeroid syndromes. J Biol Chem. 2006 Dec 29; 281(52):39741-5.
Young SG, Meta M, Yang SH, Fong LG. PMID: 17090536.
View in: PubMed Mentions: 50 Fields: Translation: HumansAnimalsCells
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Protein farnesyltransferase inhibitors and progeria. Trends Mol Med. 2006 Oct; 12(10):480-7.
Meta M, Yang SH, Bergo MO, Fong LG, Young SG. PMID: 16942914.
View in: PubMed Mentions: 13 Fields: Translation: HumansAnimalsCells
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LDL and cAMP cooperate to regulate the functional expression of the LRP in rat ovarian granulosa cells. J Lipid Res. 2006 Nov; 47(11):2538-50.
Azhar S, Medicherla S, Shen WJ, Fujioka Y, Fong LG, Reaven E, Cooper AD. PMID: 16929031.
View in: PubMed Mentions: 1 Fields: Translation: HumansAnimalsCells
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A farnesyltransferase inhibitor improves disease phenotypes in mice with a Hutchinson-Gilford progeria syndrome mutation. J Clin Invest. 2006 Aug; 116(8):2115-21.
Yang SH, Meta M, Qiao X, Frost D, Bauch J, Coffinier C, Majumdar S, Bergo MO, Young SG, Fong LG. PMID: 16862216.
View in: PubMed Mentions: 105 Fields: Translation: Animals
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Lamins A and C but not lamin B1 regulate nuclear mechanics. J Biol Chem. 2006 Sep 01; 281(35):25768-80.
Lammerding J, Fong LG, Ji JY, Reue K, Stewart CL, Young SG, Lee RT. PMID: 16825190.
View in: PubMed Mentions: 224 Fields: Translation: AnimalsCells
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A mouse monoclonal antibody specific for mouse apoB48 and apoB100 produced by immunizing "apoB39-only" mice with mouse apoB48. Biochim Biophys Acta. 2006 Feb; 1761(2):182-5.
Nguyen AT, Braschi S, Geoffrion M, Fong LG, Crooke RM, Graham MJ, Young SG, Milne R. PMID: 16551509.
View in: PubMed Mentions: 8 Fields: Translation: AnimalsCellsPHPublic Health
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Prelamin A and lamin A appear to be dispensable in the nuclear lamina. J Clin Invest. 2006 Mar; 116(3):743-52.
Fong LG, Ng JK, Lammerding J, Vickers TA, Meta M, Coté N, Gavino B, Qiao X, Chang SY, Young SR, Yang SH, Stewart CL, Lee RT, Bennett CF, Bergo MO, Young SG. PMID: 16511604.
View in: PubMed Mentions: 83 Fields: Translation: AnimalsCells
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A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria. Science. 2006 Mar 17; 311(5767):1621-3.
Fong LG, Frost D, Meta M, Qiao X, Yang SH, Coffinier C, Young SG. PMID: 16484451.
View in: PubMed Mentions: 119 Fields: Translation: AnimalsCells
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Prelamin A, Zmpste24, misshapen cell nuclei, and progeria--new evidence suggesting that protein farnesylation could be important for disease pathogenesis. J Lipid Res. 2005 Dec; 46(12):2531-58.
Young SG, Fong LG, Michaelis S. PMID: 16207929.
View in: PubMed Mentions: 106 Fields: Translation: HumansAnimalsCells
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Blocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes. Proc Natl Acad Sci U S A. 2005 Sep 06; 102(36):12873-8.
Toth JI, Yang SH, Qiao X, Beigneux AP, Gelb MH, Moulson CL, Miner JH, Young SG, Fong LG. PMID: 16129834.
View in: PubMed Mentions: 118 Fields: Translation: HumansAnimalsCells
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Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation. Proc Natl Acad Sci U S A. 2005 Jul 19; 102(29):10291-6.
Yang SH, Bergo MO, Toth JI, Qiao X, Hu Y, Sandoval S, Meta M, Bendale P, Gelb MH, Young SG, Fong LG. PMID: 16014412.
View in: PubMed Mentions: 117 Fields: Translation: AnimalsCells
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Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice. Proc Natl Acad Sci U S A. 2004 Dec 28; 101(52):18111-6.
Fong LG, Ng JK, Meta M, Coté N, Yang SH, Stewart CL, Sullivan T, Burghardt A, Majumdar S, Reue K, Bergo MO, Young SG. PMID: 15608054.
View in: PubMed Mentions: 77 Fields: Translation: HumansAnimalsCells
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Year | Publications |
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2004 | 1 | 2005 | 3 | 2006 | 8 | 2007 | 10 | 2008 | 15 | 2009 | 11 | 2010 | 12 | 2011 | 12 | 2012 | 12 | 2013 | 8 | 2014 | 13 | 2015 | 4 | 2016 | 9 | 2017 | 9 | 2018 | 11 | 2019 | 6 | 2020 | 11 |
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This graph shows the number and percent of publications by field.
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Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
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