Loren G Fong

Title(s)Professor-in-Residence, Medicine
SchoolMedicine
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    Collapse Research 
    Collapse research activities and funding
    Solving longstanding mysteries in plasma triglyceride metabolism
    NIH R01HL171737Jan 8, 2024 - Dec 31, 2027
    Role: Principal Investigator
    Development of a New Therapeutic Approach for Prelamin A Diseases
    NIH R01AG047192Apr 15, 2014 - Mar 31, 2021
    Role: Principal Investigator
    Refining Physiologic Mechanisms for Intravascular Triglyceride Metabolism
    NIH R01HL087228Feb 1, 2007 - May 31, 2025
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The Accumulation of Progerin Underlies the Loss of Aortic Smooth Muscle Cells in Hutchinson-Gilford Progeria Syndrome. bioRxiv. 2024 Nov 03. Kim PH, Kim JR, Heizer PJ, Jung H, Tu Y, Presnell A, Scheithauer J, Yu RG, Young SG, Fong LG. PMID: 39554077; PMCID: PMC11565845.
      View in: PubMed   Mentions:
    2. Distinct strategies for intravascular triglyceride metabolism in hearts of mammals and lower vertebrate species. JCI Insight. 2024 Sep 17; 9(20). Nguyen LP, Song W, Yang Y, Tran AP, Weston TA, Jung H, Tu Y, Kim PH, Kim JR, Xie K, Yu RG, Scheithauer J, Presnell AM, Ploug M, Birrane G, Arnold H, Koltowska K, Mäe MA, Betsholtz C, He L, Goodwin JL, Beigneux AP, Fong LG, Young SG. PMID: 39435661; PMCID: PMC11529983.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. Progerin forms an abnormal meshwork and has a dominant-negative effect on the nuclear lamina. Proc Natl Acad Sci U S A. 2024 Jul 02; 121(27):e2406946121. Kim PH, Kim JR, Tu Y, Jung H, Jeong JYB, Tran AP, Presnell A, Young SG, Fong LG. PMID: 38917015; PMCID: PMC11228511.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    4. Hypertriglyceridemia in Apoa5-/- mice results from reduced amounts of lipoprotein lipase in the capillary lumen. J Clin Invest. 2023 12 01; 133(23). Yang Y, Beigneux AP, Song W, Nguyen LP, Jung H, Tu Y, Weston TA, Tran CM, Xie K, Yu RG, Tran AP, Miyashita K, Nakajima K, Murakami M, Chen YQ, Zhen EY, Kim JR, Kim PH, Birrane G, Tontonoz P, Ploug M, Konrad RJ, Fong LG, Young SG. PMID: 37824203; PMCID: PMC10688983.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    5. Imaging the ANGPTL3/8-mediated regulation of lipoprotein lipase in the heart. J Lipid Res. 2023 12; 64(12):100467. Yang Y, Jung H, Konrad RJ, Fong LG, Young SG. PMID: 37898405; PMCID: PMC10755034.
      View in: PubMed   Mentions: 3     Fields:    
    6. The lipoprotein lipase that is shuttled into capillaries by GPIHBP1 enters the glycocalyx where it mediates lipoprotein processing. Proc Natl Acad Sci U S A. 2023 Oct 31; 120(44):e2313825120. Song W, Beigneux AP, Weston TA, Chen K, Yang Y, Nguyen LP, Guagliardo P, Jung H, Tran AP, Tu Y, Tran C, Birrane G, Miyashita K, Nakajima K, Murakami M, Tontonoz P, Jiang H, Ploug M, Fong LG, Young SG. PMID: 37871217; PMCID: PMC10623010.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    7. Intracapillary LPL levels in brown adipose tissue, visualized with an antibody-based approach, are regulated by ANGPTL4 at thermoneutral temperatures. Proc Natl Acad Sci U S A. 2023 02 21; 120(8):e2219833120. Song W, Yang Y, Heizer P, Tu Y, Weston TA, Kim JR, Munguia P, Jung H, Fong JL, Tran C, Ploug M, Beigneux AP, Young SG, Fong LG. PMID: 36787365; PMCID: PMC9974459.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    8. A protein of capillary endothelial cells, GPIHBP1, is crucial for plasma triglyceride metabolism. Proc Natl Acad Sci U S A. 2022 09 06; 119(36):e2211136119. Young SG, Song W, Yang Y, Birrane G, Jiang H, Beigneux AP, Ploug M, Fong LG. PMID: 36037340; PMCID: PMC9457329.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    9. Electrostatic sheathing of lipoprotein lipase is essential for its movement across capillary endothelial cells. J Clin Invest. 2022 03 01; 132(5). Song W, Beigneux AP, Winther AL, Kristensen KK, Grønnemose AL, Yang Y, Tu Y, Munguia P, Morales J, Jung H, de Jong PJ, Jung CJ, Miyashita K, Kimura T, Nakajima K, Murakami M, Birrane G, Jiang H, Tontonoz P, Ploug M, Fong LG, Young SG. PMID: 35229724; PMCID: PMC8884915.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    10. Nuclear membrane ruptures underlie the vascular pathology in a mouse model of Hutchinson-Gilford progeria syndrome. JCI Insight. 2021 08 23; 6(16). Kim PH, Chen NY, Heizer PJ, Tu Y, Weston TA, Fong JL, Gill NK, Rowat AC, Young SG, Fong LG. PMID: 34423791; PMCID: PMC8409987.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    11. Increased expression of LAP2β eliminates nuclear membrane ruptures in nuclear lamin-deficient neurons and fibroblasts. Proc Natl Acad Sci U S A. 2021 06 22; 118(25). Chen NY, Kim PH, Tu Y, Yang Y, Heizer PJ, Young SG, Fong LG. PMID: 34161290; PMCID: PMC8237679.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    12. High-resolution visualization and quantification of nucleic acid-based therapeutics in cells and tissues using Nanoscale secondary ion mass spectrometry (NanoSIMS). Nucleic Acids Res. 2021 01 11; 49(1):1-14. He C, Migawa MT, Chen K, Weston TA, Tanowitz M, Song W, Guagliardo P, Iyer KS, Bennett CF, Fong LG, Seth PP, Young SG, Jiang H. PMID: 33275144; PMCID: PMC7797060.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    13. Nuclear membrane ruptures, cell death, and tissue damage in the setting of nuclear lamin deficiencies. Nucleus. 2020 12; 11(1):237-249. Chen NY, Kim PH, Fong LG, Young SG. PMID: 32910721; PMCID: PMC7529418.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    14. Chylomicronemia from GPIHBP1 autoantibodies. J Lipid Res. 2020 11; 61(11):1365-1376. Miyashita K, Lutz J, Hudgins LC, Toib D, Ashraf AP, Song W, Murakami M, Nakajima K, Ploug M, Fong LG, Young SG, Beigneux AP. PMID: 32948662; PMCID: PMC7604722.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    15. Chylomicronemia From GPIHBP1 Autoantibodies Successfully Treated With Rituximab: A Case Report. Ann Intern Med. 2020 11 03; 173(9):764-765. Lutz J, Dunaj-Kazmierowska M, Arcan S, Kassner U, Miyashita K, Murakami M, Ploug M, Fong LG, Young SG, Nakajima K, Beigneux AP. PMID: 32777186; PMCID: PMC8174005.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    16. The structural basis for monoclonal antibody 5D2 binding to the tryptophan-rich loop of lipoprotein lipase. J Lipid Res. 2020 Oct; 61(10):1347-1359. Luz JG, Beigneux AP, Asamoto DK, He C, Song W, Allan CM, Morales J, Tu Y, Kwok A, Cottle T, Meiyappan M, Fong LG, Kim JE, Ploug M, Young SG, Birrane G. PMID: 32690595; PMCID: PMC7529051.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    17. Peroxidasin-mediated bromine enrichment of basement membranes. Proc Natl Acad Sci U S A. 2020 07 07; 117(27):15827-15836. He C, Song W, Weston TA, Tran C, Kurtz I, Zuckerman JE, Guagliardo P, Miner JH, Ivanov SV, Bougoure J, Hudson BG, Colon S, Voziyan PA, Bhave G, Fong LG, Young SG, Jiang H. PMID: 32571911; PMCID: PMC7354931.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    18. Cultured macrophages transfer surplus cholesterol into adjacent cells in the absence of serum or high-density lipoproteins. Proc Natl Acad Sci U S A. 2020 05 12; 117(19):10476-10483. He C, Jiang H, Song W, Riezman H, Tontonoz P, Weston TA, Guagliardo P, Kim PH, Jung R, Heizer P, Fong LG, Young SG. PMID: 32354992; PMCID: PMC7229689.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    19. The fatty acids from LPL-mediated processing of triglyceride-rich lipoproteins are taken up rapidly by cardiomyocytes. J Lipid Res. 2020 06; 61(6):815. Jiang H, He C, Fong LG, Young SG. PMID: 32241805; PMCID: PMC7269765.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    20. GPIHBP1, a partner protein for lipoprotein lipase, is expressed only in capillary endothelial cells. J Lipid Res. 2020 05; 61(5):591. Meng X, Zeng W, Young SG, Fong LG. PMID: 32132144; PMCID: PMC7193966.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    21. Intermittent chylomicronemia caused by intermittent GPIHBP1 autoantibodies. J Clin Lipidol. 2020 Mar - Apr; 14(2):197-200. Ashraf AP, Miyashita K, Nakajima K, Murakami M, Hegele RA, Ploug M, Fong LG, Young SG, Beigneux AP. PMID: 32107180; PMCID: PMC7166156.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    22. Deficiency in ZMPSTE24 and resulting farnesyl-prelamin A accumulation only modestly affect mouse adipose tissue stores. J Lipid Res. 2020 03; 61(3):413-421. Heizer PJ, Yang Y, Tu Y, Kim PH, Chen NY, Hu Y, Yoshinaga Y, de Jong PJ, Vergnes L, Morales JE, Li RL, Jackson N, Reue K, Young SG, Fong LG. PMID: 31941672; PMCID: PMC7053845.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    23. An absence of lamin B1 in migrating neurons causes nuclear membrane ruptures and cell death. Proc Natl Acad Sci U S A. 2019 12 17; 116(51):25870-25879. Chen NY, Yang Y, Weston TA, Belling JN, Heizer P, Tu Y, Kim P, Edillo L, Jonas SJ, Weiss PS, Fong LG, Young SG. PMID: 31796586; PMCID: PMC6926041.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    24. Release of cholesterol-rich particles from the macrophage plasma membrane during movement of filopodia and lamellipodia. Elife. 2019 09 05; 8. Hu X, Weston TA, He C, Jung RS, Heizer PJ, Young BD, Tu Y, Tontonoz P, Wohlschlegel JA, Jiang H, Young SG, Fong LG. PMID: 31486771; PMCID: PMC6750930.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    25. GPIHBP1 and Lipoprotein Lipase, Partners in Plasma Triglyceride Metabolism. Cell Metab. 2019 07 02; 30(1):51-65. Young SG, Fong LG, Beigneux AP, Allan CM, He C, Jiang H, Nakajima K, Meiyappan M, Birrane G, Ploug M. PMID: 31269429; PMCID: PMC6662658.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    26. DYT1 Dystonia Patient-Derived Fibroblasts Have Increased Deformability and Susceptibility to Damage by Mechanical Forces. Front Cell Dev Biol. 2019; 7:103. Gill NK, Ly C, Kim PH, Saunders CA, Fong LG, Young SG, Luxton GWG, Rowat AC. PMID: 31294022; PMCID: PMC6606767.
      View in: PubMed   Mentions: 7  
    27. GPIHBP1 expression in gliomas promotes utilization of lipoprotein-derived nutrients. Elife. 2019 06 06; 8. Hu X, Matsumoto K, Jung RS, Weston TA, Heizer PJ, He C, Sandoval NP, Allan CM, Tu Y, Vinters HV, Liau LM, Ellison RM, Morales JE, Baufeld LJ, Bayley NA, He L, Betsholtz C, Beigneux AP, Nathanson DA, Gerhardt H, Young SG, Fong LG, Jiang H. PMID: 31169500; PMCID: PMC6594755.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    28. Lipoprotein lipase is active as a monomer. Proc Natl Acad Sci U S A. 2019 03 26; 116(13):6319-6328. Beigneux AP, Allan CM, Sandoval NP, Cho GW, Heizer PJ, Jung RS, Stanhope KL, Havel PJ, Birrane G, Meiyappan M, Gill JE, Murakami M, Miyashita K, Nakajima K, Ploug M, Fong LG, Young SG. PMID: 30850549; PMCID: PMC6442593.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    29. An upstream enhancer regulates Gpihbp1 expression in a tissue-specific manner. J Lipid Res. 2019 04; 60(4):869-879. Allan CM, Heizer PJ, Tu Y, Sandoval NP, Jung RS, Morales JE, Sajti E, Troutman TD, Saunders TL, Cusanovich DA, Beigneux AP, Romanoski CE, Fong LG, Young SG. PMID: 30598475; PMCID: PMC6446700.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    30. Structure of the lipoprotein lipase-GPIHBP1 complex that mediates plasma triglyceride hydrolysis. Proc Natl Acad Sci U S A. 2019 01 29; 116(5):1723-1732. Birrane G, Beigneux AP, Dwyer B, Strack-Logue B, Kristensen KK, Francone OL, Fong LG, Mertens HDT, Pan CQ, Ploug M, Young SG, Meiyappan M. PMID: 30559189; PMCID: PMC6358717.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    31. Lipin 2/3 phosphatidic acid phosphatases maintain phospholipid homeostasis to regulate chylomicron synthesis. J Clin Invest. 2019 01 02; 129(1):281-295. Zhang P, Csaki LS, Ronquillo E, Baufeld LJ, Lin JY, Gutierrez A, Dwyer JR, Brindley DN, Fong LG, Tontonoz P, Young SG, Reue K. PMID: 30507612; PMCID: PMC6307960.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    32. Prelamin A causes aberrant myonuclear arrangement and results in muscle fiber weakness. JCI Insight. 2018 10 04; 3(19). Levy Y, Ross JA, Niglas M, Snetkov VA, Lynham S, Liao CY, Puckelwartz MJ, Hsu YM, McNally EM, Alsheimer M, Harridge SD, Young SG, Fong LG, Español Y, Lopez-Otin C, Kennedy BK, Lowe DA, Ochala J. PMID: 30282816; PMCID: PMC6237469.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    33. Disrupting the LINC complex in smooth muscle cells reduces aortic disease in a mouse model of Hutchinson-Gilford progeria syndrome. Sci Transl Med. 2018 09 26; 10(460). Kim PH, Luu J, Heizer P, Tu Y, Weston TA, Chen N, Lim C, Li RL, Lin PY, Dunn JCY, Hodzic D, Young SG, Fong LG. PMID: 30257952; PMCID: PMC6166472.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    34. Fibroblasts lacking nuclear lamins do not have nuclear blebs or protrusions but nevertheless have frequent nuclear membrane ruptures. Proc Natl Acad Sci U S A. 2018 10 02; 115(40):10100-10105. Chen NY, Kim P, Weston TA, Edillo L, Tu Y, Fong LG, Young SG. PMID: 30224463; PMCID: PMC6176609.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    35. NanoSIMS imaging reveals unexpected heterogeneity in nutrient uptake by brown adipocytes. Biochem Biophys Res Commun. 2018 10 12; 504(4):899-902. He C, Hu X, Weston TA, Jung RS, Heizer P, Tu Y, Ellison R, Matsumoto K, Gerhardt H, Tontonoz P, Fong LG, Young SG, Jiang H. PMID: 30224066; PMCID: PMC6476570.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    36. Macrophages release plasma membrane-derived particles rich in accessible cholesterol. Proc Natl Acad Sci U S A. 2018 09 04; 115(36):E8499-E8508. He C, Hu X, Weston TA, Jung RS, Sandhu J, Huang S, Heizer P, Kim J, Ellison R, Xu J, Kilburn M, Bensinger SJ, Riezman H, Tontonoz P, Fong LG, Jiang H, Young SG. PMID: 30127022; PMCID: PMC6130402.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    37. A disordered acidic domain in GPIHBP1 harboring a sulfated tyrosine regulates lipoprotein lipase. Proc Natl Acad Sci U S A. 2018 06 26; 115(26):E6020-E6029. Kristensen KK, Midtgaard SR, Mysling S, Kovrov O, Hansen LB, Skar-Gislinge N, Beigneux AP, Kragelund BB, Olivecrona G, Young SG, Jørgensen TJD, Fong LG, Ploug M. PMID: 29899144; PMCID: PMC6042107.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    38. NanoSIMS Analysis of Intravascular Lipolysis and Lipid Movement across Capillaries and into Cardiomyocytes. Cell Metab. 2018 May 01; 27(5):1055-1066.e3. He C, Weston TA, Jung RS, Heizer P, Larsson M, Hu X, Allan CM, Tontonoz P, Reue K, Beigneux AP, Ploug M, Holme A, Kilburn M, Guagliardo P, Ford DA, Fong LG, Young SG, Jiang H. PMID: 29719224; PMCID: PMC5945212.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    39. Impaired thermogenesis and sharp increases in plasma triglyceride levels in GPIHBP1-deficient mice during cold exposure. J Lipid Res. 2018 04; 59(4):706-713. Larsson M, Allan CM, Heizer PJ, Tu Y, Sandoval NP, Jung RS, Walzem RL, Beigneux AP, Young SG, Fong LG. PMID: 29449313; PMCID: PMC5880501.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    40. IL-10 Signaling Remodels Adipose Chromatin Architecture to Limit Thermogenesis and Energy Expenditure. Cell. 2018 01 11; 172(1-2):218-233.e17. Rajbhandari P, Thomas BJ, Feng AC, Hong C, Wang J, Vergnes L, Sallam T, Wang B, Sandhu J, Seldin MM, Lusis AJ, Fong LG, Katz M, Lee R, Young SG, Reue K, Smale ST, Tontonoz P. PMID: 29249357; PMCID: PMC5766418.
      View in: PubMed   Mentions: 98     Fields:    Translation:AnimalsCells
    41. Lipoprotein lipase reaches the capillary lumen in chickens despite an apparent absence of GPIHBP1. JCI Insight. 2017 10 19; 2(20). He C, Hu X, Jung RS, Larsson M, Tu Y, Duarte-Vogel S, Kim P, Sandoval NP, Price TR, Allan CM, Raney B, Jiang H, Bensadoun A, Walzem RL, Kuo RI, Beigneux AP, Fong LG, Young SG. PMID: 29046479; PMCID: PMC5846916.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    42. Palmoplantar keratoderma in Slurp1/Slurp2 double-knockout mice. J Dermatol Sci. 2018 Jan; 89(1):85-87. Allan CM, Heizer PJ, Jung CJ, Tu Y, Tran D, Young LC, Fong LG, de Jong PJ, Beigneux AP, Young SG. PMID: 29017797; PMCID: PMC6108176.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    43. A hypomorphic Egfr allele does not ameliorate the palmoplantar keratoderma caused by SLURP1 deficiency. Exp Dermatol. 2017 11; 26(11):1134-1136. Allan CM, Tran D, Tu Y, Heizer PJ, Young LC, Fong LG, Beigneux AP, Young SG. PMID: 28418591; PMCID: PMC5705011.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    44. Apolipoprotein C-III inhibits triglyceride hydrolysis by GPIHBP1-bound LPL. J Lipid Res. 2017 09; 58(9):1893-1902. Larsson M, Allan CM, Jung RS, Heizer PJ, Beigneux AP, Young SG, Fong LG. PMID: 28694296; PMCID: PMC5580902.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    45. GPIHBP1 autoantibodies in a patient with unexplained chylomicronemia. J Clin Lipidol. 2017 Jul - Aug; 11(4):964-971. Hu X, Dallinga-Thie GM, Hovingh GK, Chang SY, Sandoval NP, Dang TLP, Fukamachi I, Miyashita K, Nakajima K, Murakami M, Fong LG, Ploug M, Young SG, Beigneux AP. PMID: 28666713; PMCID: PMC5568906.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    46. Mutating a conserved cysteine in GPIHBP1 reduces amounts of GPIHBP1 in capillaries and abolishes LPL binding. J Lipid Res. 2017 07; 58(7):1453-1461. Allan CM, Jung CJ, Larsson M, Heizer PJ, Tu Y, Sandoval NP, Dang TLP, Jung RS, Beigneux AP, de Jong PJ, Fong LG, Young SG. PMID: 28476858; PMCID: PMC5496041.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    47. Autoantibodies against GPIHBP1 as a Cause of Hypertriglyceridemia. N Engl J Med. 2017 04 27; 376(17):1647-1658. Beigneux AP, Miyashita K, Ploug M, Blom DJ, Ai M, Linton MF, Khovidhunkit W, Dufour R, Garg A, McMahon MA, Pullinger CR, Sandoval NP, Hu X, Allan CM, Larsson M, Machida T, Murakami M, Reue K, Tontonoz P, Goldberg IJ, Moulin P, Charrière S, Fong LG, Nakajima K, Young SG. PMID: 28402248; PMCID: PMC5555413.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansCells
    48. High-resolution imaging and quantification of plasma membrane cholesterol by NanoSIMS. Proc Natl Acad Sci U S A. 2017 02 21; 114(8):2000-2005. He C, Hu X, Jung RS, Weston TA, Sandoval NP, Tontonoz P, Kilburn MR, Fong LG, Young SG, Jiang H. PMID: 28167768; PMCID: PMC5338444.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    49. Monoclonal antibodies that bind to the Ly6 domain of GPIHBP1 abolish the binding of LPL. J Lipid Res. 2017 01; 58(1):208-215. Hu X, Sleeman MW, Miyashita K, Linton MF, Allan CM, He C, Larsson M, Tu Y, Sandoval NP, Jung RS, Mapar A, Machida T, Murakami M, Nakajima K, Ploug M, Fong LG, Young SG, Beigneux AP. PMID: 27875259; PMCID: PMC5234723.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    50. Mobility of "HSPG-bound" LPL explains how LPL is able to reach GPIHBP1 on capillaries. J Lipid Res. 2017 01; 58(1):216-225. Allan CM, Larsson M, Jung RS, Ploug M, Bensadoun A, Beigneux AP, Fong LG, Young SG. PMID: 27811232; PMCID: PMC5234724.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    51. NanoSIMS imaging: an approach for visualizing and quantifying lipids in cells and tissues. J Investig Med. 2017 03; 65(3):669-672. He C, Fong LG, Young SG, Jiang H. PMID: 27793974; PMCID: PMC5493309.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    52. LMNA missense mutations causing familial partial lipodystrophy do not lead to an accumulation of prelamin A. Nucleus. 2016 Sep 02; 7(5):512-521. Tu Y, Sánchez-Iglesias S, Araújo-Vilar D, Fong LG, Young SG. PMID: 27841971; PMCID: PMC5120598.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    53. An LPL-specific monoclonal antibody, 88B8, that abolishes the binding of LPL to GPIHBP1. J Lipid Res. 2016 10; 57(10):1889-1898. Allan CM, Larsson M, Hu X, He C, Jung RS, Mapar A, Voss C, Miyashita K, Machida T, Murakami M, Nakajima K, Bensadoun A, Ploug M, Fong LG, Young SG, Beigneux AP. PMID: 27494936; PMCID: PMC5036369.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    54. GPIHBP1 and Plasma Triglyceride Metabolism. Trends Endocrinol Metab. 2016 07; 27(7):455-469. Fong LG, Young SG, Beigneux AP, Bensadoun A, Oberer M, Jiang H, Ploug M. PMID: 27185325; PMCID: PMC4927088.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimals
    55. Lamin B1 and lamin B2 are long-lived proteins with distinct functions in retinal development. Mol Biol Cell. 2016 06 15; 27(12):1928-37. Razafsky D, Ward C, Potter C, Zhu W, Xue Y, Kefalov VJ, Fong LG, Young SG, Hodzic D. PMID: 27075175; PMCID: PMC4907726.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    56. Modulation of LMNA splicing as a strategy to treat prelamin A diseases. J Clin Invest. 2016 Apr 01; 126(4):1592-602. Lee JM, Nobumori C, Tu Y, Choi C, Yang SH, Jung HJ, Vickers TA, Rigo F, Bennett CF, Young SG, Fong LG. PMID: 26999604; PMCID: PMC4811112.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    57. The acidic domain of the endothelial membrane protein GPIHBP1 stabilizes lipoprotein lipase activity by preventing unfolding of its catalytic domain. Elife. 2016 Jan 03; 5:e12095. Mysling S, Kristensen KK, Larsson M, Beigneux AP, Gårdsvoll H, Fong LG, Bensadouen A, Jørgensen TJ, Young SG, Ploug M. PMID: 26725083; PMCID: PMC4755760.
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    58. SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression. J Lipid Res. 2016 Mar; 57(3):410-21. Vergnes L, Chin RG, de Aguiar Vallim T, Fong LG, Osborne TF, Young SG, Reue K. PMID: 26685326; PMCID: PMC4766990.
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    59. Palmoplantar Keratoderma in Slurp2-Deficient Mice. J Invest Dermatol. 2016 Feb; 136(2):436-443. Allan CM, Procaccia S, Tran D, Tu Y, Barnes RH, Larsson M, Allan BB, Young LC, Hong C, Tontonoz P, Fong LG, Young SG, Beigneux AP. PMID: 26967477; PMCID: PMC4789766.
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    60. Nuclear envelope protein Lem2 is required for mouse development and regulates MAP and AKT kinases. PLoS One. 2015; 10(3):e0116196. Tapia O, Fong LG, Huber MD, Young SG, Gerace L. PMID: 25790465; PMCID: PMC4366207.
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    61. Mice that express farnesylated versions of prelamin A in neurons develop achalasia. Hum Mol Genet. 2015 May 15; 24(10):2826-40. Yang SH, Procaccia S, Jung HJ, Nobumori C, Tatar A, Tu Y, Bayguinov YR, Hwang SJ, Tran D, Ward SM, Fong LG, Young SG. PMID: 25652409; PMCID: PMC4406294.
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    62. GPIHBP1 missense mutations often cause multimerization of GPIHBP1 and thereby prevent lipoprotein lipase binding. Circ Res. 2015 Feb 13; 116(4):624-32. Beigneux AP, Fong LG, Bensadoun A, Davies BS, Oberer M, Gårdsvoll H, Ploug M, Young SG. PMID: 25387803; PMCID: PMC4329087.
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    63. The LXR-Idol axis differentially regulates plasma LDL levels in primates and mice. Cell Metab. 2014 Nov 04; 20(5):910-918. Hong C, Marshall SM, McDaniel AL, Graham M, Layne JD, Cai L, Scotti E, Boyadjian R, Kim J, Chamberlain BT, Tangirala RK, Jung ME, Fong L, Lee R, Young SG, Temel RE, Tontonoz P. PMID: 25440061; PMCID: PMC4261644.
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    64. Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs. J Clin Invest. 2014 Dec; 124(12):5368-84. Degagné E, Pandurangan A, Bandhuvula P, Kumar A, Eltanawy A, Zhang M, Yoshinaga Y, Nefedov M, de Jong PJ, Fong LG, Young SG, Bittman R, Ahmedi Y, Saba JD. PMID: 25347472; PMCID: PMC4348973.
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    65. An absence of nuclear lamins in keratinocytes leads to ichthyosis, defective epidermal barrier function, and intrusion of nuclear membranes and endoplasmic reticulum into the nuclear chromatin. Mol Cell Biol. 2014 Dec; 34(24):4534-44. Jung HJ, Tatar A, Tu Y, Nobumori C, Yang SH, Goulbourne CN, Herrmann H, Fong LG, Young SG. PMID: 25312645; PMCID: PMC4248738.
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    66. High-resolution imaging of dietary lipids in cells and tissues by NanoSIMS analysis. J Lipid Res. 2014 Oct; 55(10):2156-66. Jiang H, Goulbourne CN, Tatar A, Turlo K, Wu D, Beigneux AP, Grovenor CR, Fong LG, Young SG. PMID: 25143463; PMCID: PMC4174007.
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    67. Do lamin B1 and lamin B2 have redundant functions? Nucleus. 2014 Jul-Aug; 5(4):287-92. Lee JM, Jung HJ, Fong LG, Young SG. PMID: 25482116; PMCID: PMC4152341.
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    68. Multimerization of glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) and familial chylomicronemia from a serine-to-cysteine substitution in GPIHBP1 Ly6 domain. J Biol Chem. 2014 Jul 11; 289(28):19491-9. Plengpanich W, Young SG, Khovidhunkit W, Bensadoun A, Karnman H, Ploug M, Gårdsvoll H, Leung CS, Adeyo O, Larsson M, Muanpetch S, Charoen S, Fong LG, Niramitmahapanya S, Beigneux AP. PMID: 24847059; PMCID: PMC4094059.
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    69. Nuclear lamins and neurobiology. Mol Cell Biol. 2014 Aug; 34(15):2776-85. Young SG, Jung HJ, Lee JM, Fong LG. PMID: 24842906; PMCID: PMC4135577.
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    70. The GPIHBP1-LPL complex is responsible for the margination of triglyceride-rich lipoproteins in capillaries. Cell Metab. 2014 May 06; 19(5):849-60. Goulbourne CN, Gin P, Tatar A, Nobumori C, Hoenger A, Jiang H, Grovenor CR, Adeyo O, Esko JD, Goldberg IJ, Reue K, Tontonoz P, Bensadoun A, Beigneux AP, Young SG, Fong LG. PMID: 24726386; PMCID: PMC4143151.
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    71. Equivalent binding of wild-type lipoprotein lipase (LPL) and S447X-LPL to GPIHBP1, the endothelial cell LPL transporter. Biochim Biophys Acta. 2014 Jul; 1841(7):963-9. Turlo K, Leung CS, Seo JJ, Goulbourne CN, Adeyo O, Gin P, Voss C, Bensadoun A, Fong LG, Young SG, Beigneux AP. PMID: 24704550; PMCID: PMC4212522.
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    72. A new monoclonal antibody, 4-1a, that binds to the amino terminus of human lipoprotein lipase. Biochim Biophys Acta. 2014 Jul; 1841(7):970-6. Bensadoun A, Mottler CD, Pelletier C, Wu D, Seo JJ, Leung CS, Adeyo O, Goulbourne CN, Gin P, Fong LG, Young SG, Beigneux AP. PMID: 24681165; PMCID: PMC4222086.
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    73. Reciprocal knock-in mice to investigate the functional redundancy of lamin B1 and lamin B2. Mol Biol Cell. 2014 May; 25(10):1666-75. Lee JM, Tu Y, Tatar A, Wu D, Nobumori C, Jung HJ, Yoshinaga Y, Coffinier C, de Jong PJ, Fong LG, Young SG. PMID: 24672053; PMCID: PMC4019497.
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    74. Palmoplantar keratoderma along with neuromuscular and metabolic phenotypes in Slurp1-deficient mice. J Invest Dermatol. 2014 Jun; 134(6):1589-1598. Adeyo O, Allan BB, Barnes RH, Goulbourne CN, Tatar A, Tu Y, Young LC, Weinstein MM, Tontonoz P, Fong LG, Beigneux AP, Young SG. PMID: 24499735; PMCID: PMC4214150.
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    75. Lipin-1 and lipin-3 together determine adiposity in vivo. Mol Metab. 2014 Apr; 3(2):145-54. Csaki LS, Dwyer JR, Li X, Nguyen MH, Dewald J, Brindley DN, Lusis AJ, Yoshinaga Y, de Jong P, Fong L, Young SG, Reue K. PMID: 24634820; PMCID: PMC3953701.
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    76. New Lmna knock-in mice provide a molecular mechanism for the 'segmental aging' in Hutchinson-Gilford progeria syndrome. Hum Mol Genet. 2014 Mar 15; 23(6):1506-15. Jung HJ, Tu Y, Yang SH, Tatar A, Nobumori C, Wu D, Young SG, Fong LG. PMID: 24203701; PMCID: PMC3929089.
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    77. Targeting isoprenylcysteine methylation ameliorates disease in a mouse model of progeria. Science. 2013 Jun 14; 340(6138):1330-3. Ibrahim MX, Sayin VI, Akula MK, Liu M, Fong LG, Young SG, Bergo MO. PMID: 23686339; PMCID: PMC4295631.
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    78. Farnesylation of lamin B1 is important for retention of nuclear chromatin during neuronal migration. Proc Natl Acad Sci U S A. 2013 May 21; 110(21):E1923-32. Jung HJ, Nobumori C, Goulbourne CN, Tu Y, Lee JM, Tatar A, Wu D, Yoshinaga Y, de Jong PJ, Coffinier C, Fong LG, Young SG. PMID: 23650370; PMCID: PMC3666708.
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    79. Lipins, lipinopathies, and the modulation of cellular lipid storage and signaling. Prog Lipid Res. 2013 Jul; 52(3):305-16. Csaki LS, Dwyer JR, Fong LG, Tontonoz P, Young SG, Reue K. PMID: 23603613; PMCID: PMC3830937.
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    80. Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs. Cell Metab. 2013 Mar 05; 17(3):423-35. Villanueva CJ, Vergnes L, Wang J, Drew BG, Hong C, Tu Y, Hu Y, Peng X, Xu F, Saez E, Wroblewski K, Hevener AL, Reue K, Fong LG, Young SG, Tontonoz P. PMID: 23473036; PMCID: PMC3626567.
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    81. Targeting protein prenylation in progeria. Sci Transl Med. 2013 Feb 06; 5(171):171ps3. Young SG, Yang SH, Davies BS, Jung HJ, Fong LG. PMID: 23390246; PMCID: PMC3725554.
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    82. IDOL stimulates clathrin-independent endocytosis and multivesicular body-mediated lysosomal degradation of the low-density lipoprotein receptor. Mol Cell Biol. 2013 Apr; 33(8):1503-14. Scotti E, Calamai M, Goulbourne CN, Zhang L, Hong C, Lin RR, Choi J, Pilch PF, Fong LG, Zou P, Ting AY, Pavone FS, Young SG, Tontonoz P. PMID: 23382078; PMCID: PMC3624246.
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    83. Compromised mitochondrial fatty acid synthesis in transgenic mice results in defective protein lipoylation and energy disequilibrium. PLoS One. 2012; 7(10):e47196. Smith S, Witkowski A, Moghul A, Yoshinaga Y, Nefedov M, de Jong P, Feng D, Fong L, Tu Y, Hu Y, Young SG, Pham T, Cheung C, Katzman SM, Brand MD, Quinlan CL, Fens M, Kuypers F, Misquitta S, Griffey SM, Tran S, Gharib A, Knudsen J, Hannibal-Bach HK, Wang G, Larkin S, Thweatt J, Pasta S. PMID: 23077570; PMCID: PMC3471957.
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    84. Nuclear lamins in the brain - new insights into function and regulation. Mol Neurobiol. 2013 Feb; 47(1):290-301. Jung HJ, Lee JM, Yang SH, Young SG, Fong LG. PMID: 23065386; PMCID: PMC3538886.
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    85. Assessing mechanisms of GPIHBP1 and lipoprotein lipase movement across endothelial cells. J Lipid Res. 2012 Dec; 53(12):2690-7. Davies BS, Goulbourne CN, Barnes RH, Turlo KA, Gin P, Vaughan S, Vaux DJ, Bensadoun A, Beigneux AP, Fong LG, Young SG. PMID: 23008484; PMCID: PMC3494248.
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    86. Feedback regulation of cholesterol uptake by the LXR-IDOL-LDLR axis. Arterioscler Thromb Vasc Biol. 2012 Nov; 32(11):2541-6. Zhang L, Reue K, Fong LG, Young SG, Tontonoz P. PMID: 22936343; PMCID: PMC4280256.
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    87. Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum. Proc Natl Acad Sci U S A. 2012 Sep 11; 109(37):E2486-95. Dwyer JR, Donkor J, Zhang P, Csaki LS, Vergnes L, Lee JM, Dewald J, Brindley DN, Atti E, Tetradis S, Yoshinaga Y, De Jong PJ, Fong LG, Young SG, Reue K. PMID: 22908270; PMCID: PMC3443145.
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    88. Sphingosine-1-phosphate lyase expression in embryonic and adult murine tissues. J Lipid Res. 2012 Sep; 53(9):1920-31. Borowsky AD, Bandhuvula P, Kumar A, Yoshinaga Y, Nefedov M, Fong LG, Zhang M, Baridon B, Dillard L, de Jong P, Young SG, West DB, Saba JD. PMID: 22781001; PMCID: PMC3413231.
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    89. Chylomicronemia mutations yield new insights into interactions between lipoprotein lipase and GPIHBP1. Hum Mol Genet. 2012 Jul 01; 21(13):2961-72. Gin P, Goulbourne CN, Adeyo O, Beigneux AP, Davies BS, Tat S, Voss CV, Bensadoun A, Fong LG, Young SG. PMID: 22493000; PMCID: PMC3373243.
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    90. Inhibitors of protein geranylgeranyltransferase-I lead to prelamin A accumulation in cells by inhibiting ZMPSTE24. J Lipid Res. 2012 Jun; 53(6):1176-82. Chang SY, Hudon-Miller SE, Yang SH, Jung HJ, Lee JM, Farber E, Subramanian T, Andres DA, Spielmann HP, Hrycyna CA, Young SG, Fong LG. PMID: 22448028; PMCID: PMC3351824.
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    91. Lowering plasma cholesterol by raising LDL receptors--revisited. N Engl J Med. 2012 Mar 22; 366(12):1154-5. Young SG, Fong LG. PMID: 22435375; PMCID: PMC5611813.
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    92. Understanding the roles of nuclear A- and B-type lamins in brain development. J Biol Chem. 2012 May 11; 287(20):16103-10. Young SG, Jung HJ, Coffinier C, Fong LG. PMID: 22416132; PMCID: PMC3351360.
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    93. New wrinkles in lipoprotein lipase biology. Curr Opin Lipidol. 2012 Feb; 23(1):35-42. Davies BS, Beigneux AP, Fong LG, Young SG. PMID: 22123668; PMCID: PMC3383841.
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    94. Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA. Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7):E423-31. Jung HJ, Coffinier C, Choe Y, Beigneux AP, Davies BS, Yang SH, Barnes RH, Hong J, Sun T, Pleasure SJ, Young SG, Fong LG. PMID: 22308344; PMCID: PMC3289373.
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    95. Reciprocal metabolic perturbations in the adipose tissue and liver of GPIHBP1-deficient mice. Arterioscler Thromb Vasc Biol. 2012 Feb; 32(2):230-5. Weinstein MM, Goulbourne CN, Davies BS, Tu Y, Barnes RH, Watkins SM, Davis R, Reue K, Tontonoz P, Beigneux AP, Fong LG, Young SG. PMID: 22173228; PMCID: PMC3281771.
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    96. Are B-type lamins essential in all mammalian cells? Nucleus. 2011 Nov-Dec; 2(6):562-9. Yang SH, Jung HJ, Coffinier C, Fong LG, Young SG. PMID: 22127257; PMCID: PMC3324344.
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    97. Severe hepatocellular disease in mice lacking one or both CaaX prenyltransferases. J Lipid Res. 2012 Jan; 53(1):77-86. Yang SH, Chang SY, Tu Y, Lawson GW, Bergo MO, Fong LG, Young SG. PMID: 22039581; PMCID: PMC3243483.
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    98. The arrestin domain-containing 3 protein regulates body mass and energy expenditure. Cell Metab. 2011 Nov 02; 14(5):671-83. Patwari P, Emilsson V, Schadt EE, Chutkow WA, Lee S, Marsili A, Zhang Y, Dobrin R, Cohen DE, Larsen PR, Zavacki AM, Fong LG, Young SG, Lee RT. PMID: 21982743; PMCID: PMC3216113.
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    99. Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons. Mol Biol Cell. 2011 Dec; 22(23):4683-93. Coffinier C, Jung HJ, Nobumori C, Chang S, Tu Y, Barnes RH, Yoshinaga Y, de Jong PJ, Vergnes L, Reue K, Fong LG, Young SG. PMID: 21976703; PMCID: PMC3226484.
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    100. GPIHBP1, an endothelial cell transporter for lipoprotein lipase. J Lipid Res. 2011 Nov; 52(11):1869-84. Young SG, Davies BS, Voss CV, Gin P, Weinstein MM, Tontonoz P, Reue K, Bensadoun A, Fong LG, Beigneux AP. PMID: 21844202; PMCID: PMC3196223.
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    101. An absence of both lamin B1 and lamin B2 in keratinocytes has no effect on cell proliferation or the development of skin and hair. Hum Mol Genet. 2011 Sep 15; 20(18):3537-44. Yang SH, Chang SY, Yin L, Tu Y, Hu Y, Yoshinaga Y, de Jong PJ, Fong LG, Young SG. PMID: 21659336; PMCID: PMC3159554.
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    102. Mutations in lipoprotein lipase that block binding to the endothelial cell transporter GPIHBP1. Proc Natl Acad Sci U S A. 2011 May 10; 108(19):7980-4. Voss CV, Davies BS, Tat S, Gin P, Fong LG, Pelletier C, Mottler CD, Bensadoun A, Beigneux AP, Young SG. PMID: 21518912; PMCID: PMC3093490.
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    103. Assessing the role of the glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) three-finger domain in binding lipoprotein lipase. J Biol Chem. 2011 Jun 03; 286(22):19735-43. Beigneux AP, Davies BS, Tat S, Chen J, Gin P, Voss CV, Weinstein MM, Bensadoun A, Pullinger CR, Fong LG, Young SG. PMID: 21478160; PMCID: PMC3103352.
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    104. Protein farnesylation inhibitors cause donut-shaped cell nuclei attributable to a centrosome separation defect. Proc Natl Acad Sci U S A. 2011 Mar 22; 108(12):4997-5002. Verstraeten VL, Peckham LA, Olive M, Capell BC, Collins FS, Nabel EG, Young SG, Fong LG, Lammerding J. PMID: 21383178; PMCID: PMC3064351.
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    105. Targeted disruption of the idol gene alters cellular regulation of the low-density lipoprotein receptor by sterols and liver x receptor agonists. Mol Cell Biol. 2011 May; 31(9):1885-93. Scotti E, Hong C, Yoshinaga Y, Tu Y, Hu Y, Zelcer N, Boyadjian R, de Jong PJ, Young SG, Fong LG, Tontonoz P. PMID: 21343340; PMCID: PMC3133228.
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    106. Investigating the purpose of prelamin A processing. Nucleus. 2011 Jan-Feb; 2(1):4-9. Davies BS, Coffinier C, Yang SH, Barnes RH, Jung HJ, Young SG, Fong LG. PMID: 21647293; PMCID: PMC3104803.
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    107. Absence of progeria-like disease phenotypes in knock-in mice expressing a non-farnesylated version of progerin. Hum Mol Genet. 2011 Feb 01; 20(3):436-44. Yang SH, Chang SY, Ren S, Wang Y, Andres DA, Spielmann HP, Fong LG, Young SG. PMID: 21088111; PMCID: PMC3016906.
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    108. Deletion of the basement membrane heparan sulfate proteoglycan type XVIII collagen causes hypertriglyceridemia in mice and humans. PLoS One. 2010 Nov 10; 5(11):e13919. Bishop JR, Passos-Bueno MR, Fong L, Stanford KI, Gonzales JC, Yeh E, Young SG, Bensadoun A, Witztum JL, Esko JD, Moulton KS. PMID: 21085708; PMCID: PMC2978080.
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    109. Binding preferences for GPIHBP1, a glycosylphosphatidylinositol-anchored protein of capillary endothelial cells. Arterioscler Thromb Vasc Biol. 2011 Jan; 31(1):176-82. Gin P, Beigneux AP, Voss C, Davies BS, Beckstead JA, Ryan RO, Bensadoun A, Fong LG, Young SG. PMID: 20966398; PMCID: PMC3004026.
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    110. Unexpected expression pattern for glycosylphosphatidylinositol-anchored HDL-binding protein 1 (GPIHBP1) in mouse tissues revealed by positron emission tomography scanning. J Biol Chem. 2010 Dec 10; 285(50):39239-48. Olafsen T, Young SG, Davies BS, Beigneux AP, Kenanova VE, Voss C, Young G, Wong KP, Barnes RH, Tu Y, Weinstein MM, Nobumori C, Huang SC, Goldberg IJ, Bensadoun A, Wu AM, Fong LG. PMID: 20889497; PMCID: PMC2998116.
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    111. Cholesterol intake modulates plasma triglyceride levels in glycosylphosphatidylinositol HDL-binding protein 1-deficient mice. Arterioscler Thromb Vasc Biol. 2010 Nov; 30(11):2106-13. Weinstein MM, Tu Y, Beigneux AP, Davies BS, Gin P, Voss C, Walzem RL, Reue K, Tontonoz P, Bensadoun A, Fong LG, Young SG. PMID: 20814015; PMCID: PMC2959134.
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    112. LINCing lamin B2 to neuronal migration: growing evidence for cell-specific roles of B-type lamins. Nucleus. 2010 Sep-Oct; 1(5):407-11. Coffinier C, Fong LG, Young SG. PMID: 21278813; PMCID: PMC3027074.
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    113. GPIHBP1 is responsible for the entry of lipoprotein lipase into capillaries. Cell Metab. 2010 Jul 07; 12(1):42-52. Davies BS, Beigneux AP, Barnes RH, Tu Y, Gin P, Weinstein MM, Nobumori C, Nyrén R, Goldberg I, Olivecrona G, Bensadoun A, Young SG, Fong LG. PMID: 20620994; PMCID: PMC2913606.
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    114. Direct synthesis of lamin A, bypassing prelamin a processing, causes misshapen nuclei in fibroblasts but no detectable pathology in mice. J Biol Chem. 2010 Jul 02; 285(27):20818-26. Coffinier C, Jung HJ, Li Z, Nobumori C, Yun UJ, Farber EA, Davies BS, Weinstein MM, Yang SH, Lammerding J, Farahani JN, Bentolila LA, Fong LG, Young SG. PMID: 20439468; PMCID: PMC2898298.
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    115. An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria. Hum Mol Genet. 2010 Jul 01; 19(13):2682-94. Davies BS, Barnes RH, Tu Y, Ren S, Andres DA, Spielmann HP, Lammerding J, Wang Y, Young SG, Fong LG. PMID: 20421363; PMCID: PMC2883346.
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    116. Abnormal development of the cerebral cortex and cerebellum in the setting of lamin B2 deficiency. Proc Natl Acad Sci U S A. 2010 Mar 16; 107(11):5076-81. Coffinier C, Chang SY, Nobumori C, Tu Y, Farber EA, Toth JI, Fong LG, Young SG. PMID: 20145110; PMCID: PMC2841930.
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    117. Chylomicronemia with low postheparin lipoprotein lipase levels in the setting of GPIHBP1 defects. Circ Cardiovasc Genet. 2010 Apr; 3(2):169-78. Franssen R, Young SG, Peelman F, Hertecant J, Sierts JA, Schimmel AW, Bensadoun A, Kastelein JJ, Fong LG, Dallinga-Thie GM, Beigneux AP. PMID: 20124439; PMCID: PMC2858258.
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    118. Genetic studies on the functional relevance of the protein prenyltransferases in skin keratinocytes. Hum Mol Genet. 2010 Apr 15; 19(8):1603-17. Lee R, Chang SY, Trinh H, Tu Y, White AC, Davies BS, Bergo MO, Fong LG, Lowry WE, Young SG. PMID: 20106865; PMCID: PMC2846164.
      View in: PubMed   Mentions: 25     Fields:    
    119. Mutation of conserved cysteines in the Ly6 domain of GPIHBP1 in familial chylomicronemia. J Lipid Res. 2010 Jun; 51(6):1535-45. Olivecrona G, Ehrenborg E, Semb H, Makoveichuk E, Lindberg A, Hayden MR, Gin P, Davies BS, Weinstein MM, Fong LG, Beigneux AP, Young SG, Olivecrona T, Hernell O. PMID: 20026666; PMCID: PMC3035517.
      View in: PubMed   Mentions: 58     Fields:    
    120. Assessing the efficacy of protein farnesyltransferase inhibitors in mouse models of progeria. J Lipid Res. 2010 Feb; 51(2):400-5. Yang SH, Chang SY, Andres DA, Spielmann HP, Young SG, Fong LG. PMID: 19965595; PMCID: PMC2803242.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    121. Chylomicronemia elicits atherosclerosis in mice--brief report. Arterioscler Thromb Vasc Biol. 2010 Jan; 30(1):20-3. Weinstein MM, Yin L, Tu Y, Wang X, Wu X, Castellani LW, Walzem RL, Lusis AJ, Fong LG, Beigneux AP, Young SG. PMID: 19815815; PMCID: PMC2796285.
      View in: PubMed   Mentions: 26     Fields:    
    122. A novel approach to tag and identify geranylgeranylated proteins. Electrophoresis. 2009 Oct; 30(20):3598-606. Chan LN, Hart C, Guo L, Nyberg T, Davies BS, Fong LG, Young SG, Agnew BJ, Tamanoi F. PMID: 19784953; PMCID: PMC2855049.
      View in: PubMed   Mentions: 27     Fields:    
    123. Highly conserved cysteines within the Ly6 domain of GPIHBP1 are crucial for the binding of lipoprotein lipase. J Biol Chem. 2009 Oct 30; 284(44):30240-7. Beigneux AP, Gin P, Davies BS, Weinstein MM, Bensadoun A, Fong LG, Young SG. PMID: 19726683; PMCID: PMC2781579.
      View in: PubMed   Mentions: 45     Fields:    
    124. Laminopathies and the long strange trip from basic cell biology to therapy. J Clin Invest. 2009 Jul; 119(7):1825-36. Worman HJ, Fong LG, Muchir A, Young SG. PMID: 19587457; PMCID: PMC2701866.
      View in: PubMed   Mentions: 127     Fields:    Translation:HumansAnimalsCells
    125. Sterol regulatory element binding protein 1a regulates hepatic fatty acid partitioning by activating acetyl coenzyme A carboxylase 2. Mol Cell Biol. 2009 Sep; 29(17):4864-72. Im SS, Hammond LE, Yousef L, Nugas-Selby C, Shin DJ, Seo YK, Fong LG, Young SG, Osborne TF. PMID: 19564420; PMCID: PMC2725716.
      View in: PubMed   Mentions: 14     Fields:    
    126. GPIHBP1 and lipolysis: an update. Curr Opin Lipidol. 2009 Jun; 20(3):211-6. Beigneux AP, Weinstein MM, Davies BS, Gin P, Bensadoun A, Fong LG, Young SG. PMID: 19369870; PMCID: PMC2810420.
      View in: PubMed   Mentions: 11     Fields:    
    127. Activating the synthesis of progerin, the mutant prelamin A in Hutchinson-Gilford progeria syndrome, with antisense oligonucleotides. Hum Mol Genet. 2009 Jul 01; 18(13):2462-71. Fong LG, Vickers TA, Farber EA, Choi C, Yun UJ, Hu Y, Yang SH, Coffinier C, Lee R, Yin L, Davies BS, Andres DA, Spielmann HP, Bennett CF, Young SG. PMID: 19376814; PMCID: PMC2694694.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    128. Chylomicronemia with a mutant GPIHBP1 (Q115P) that cannot bind lipoprotein lipase. Arterioscler Thromb Vasc Biol. 2009 Jun; 29(6):956-62. Beigneux AP, Franssen R, Bensadoun A, Gin P, Melford K, Peter J, Walzem RL, Weinstein MM, Davies BS, Kuivenhoven JA, Kastelein JJ, Fong LG, Dallinga-Thie GM, Young SG. PMID: 19304573; PMCID: PMC2811263.
      View in: PubMed   Mentions: 62     Fields:    
    129. The posttranslational processing of prelamin A and disease. Annu Rev Genomics Hum Genet. 2009; 10:153-74. Davies BS, Fong LG, Yang SH, Coffinier C, Young SG. PMID: 19453251; PMCID: PMC2846822.
      View in: PubMed   Mentions: 64     Fields:    
    130. Caution! Analyze transcripts from conditional knockout alleles. Transgenic Res. 2009 Jun; 18(3):483-9. Yang SH, Bergo MO, Farber E, Qiao X, Fong LG, Young SG. PMID: 19093225; PMCID: PMC2679093.
      View in: PubMed   Mentions: 9     Fields:    
    131. GPIHBP1, a GPI-anchored protein required for the lipolytic processing of triglyceride-rich lipoproteins. J Lipid Res. 2009 Apr; 50 Suppl:S57-62. Beigneux AP, Davies BS, Bensadoun A, Fong LG, Young SG. PMID: 18854402; PMCID: PMC2674691.
      View in: PubMed   Mentions: 24     Fields:    
    132. Abnormal patterns of lipoprotein lipase release into the plasma in GPIHBP1-deficient mice. J Biol Chem. 2008 Dec 12; 283(50):34511-8. Weinstein MM, Yin L, Beigneux AP, Davies BS, Gin P, Estrada K, Melford K, Bishop JR, Esko JD, Dallinga-Thie GM, Fong LG, Bensadoun A, Young SG. PMID: 18845532; PMCID: PMC2596386.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    133. Progerin elicits disease phenotypes of progeria in mice whether or not it is farnesylated. J Clin Invest. 2008 Oct; 118(10):3291-300. Yang SH, Andres DA, Spielmann HP, Young SG, Fong LG. PMID: 18769635; PMCID: PMC2525700.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    134. The expression of GPIHBP1, an endothelial cell binding site for lipoprotein lipase and chylomicrons, is induced by peroxisome proliferator-activated receptor-gamma. Mol Endocrinol. 2008 Nov; 22(11):2496-504. Davies BS, Waki H, Beigneux AP, Farber E, Weinstein MM, Wilpitz DC, Tai LJ, Evans RM, Fong LG, Tontonoz P, Young SG. PMID: 18787041; PMCID: PMC2582544.
      View in: PubMed   Mentions: 26     Fields:    
    135. Increasing the length of progerin's isoprenyl anchor does not worsen bone disease or survival in mice with Hutchinson-Gilford progeria syndrome. J Lipid Res. 2009 Jan; 50(1):126-34. Davies BS, Yang SH, Farber E, Lee R, Buck SB, Andres DA, Spielmann HP, Agnew BJ, Tamanoi F, Fong LG, Young SG. PMID: 18757838; PMCID: PMC3837462.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    136. The acidic domain of GPIHBP1 is important for the binding of lipoprotein lipase and chylomicrons. J Biol Chem. 2008 Oct 24; 283(43):29554-62. Gin P, Yin L, Davies BS, Weinstein MM, Ryan RO, Bensadoun A, Fong LG, Young SG, Beigneux AP. PMID: 18713736; PMCID: PMC2662032.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    137. HIV-protease inhibitors block the enzymatic activity of purified Ste24p. Biochem Biophys Res Commun. 2008 Sep 19; 374(2):365-8. Hudon SE, Coffinier C, Michaelis S, Fong LG, Young SG, Hrycyna CA. PMID: 18639527; PMCID: PMC2543933.
      View in: PubMed   Mentions: 22     Fields:    
    138. PCSK9 function and physiology. J Lipid Res. 2008 Jul; 49(7):1595-9. Peterson AS, Fong LG, Young SG. PMID: 18663786; PMCID: PMC3837453.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    139. PCSK9 function and physiology. J Lipid Res. 2008 Jun; 49(6):1152-6. Peterson AS, Fong LG, Young SG. PMID: 18375913; PMCID: PMC2386899.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    140. Glycosylation of Asn-76 in mouse GPIHBP1 is critical for its appearance on the cell surface and the binding of chylomicrons and lipoprotein lipase. J Lipid Res. 2008 Jun; 49(6):1312-21. Beigneux AP, Gin P, Davies BS, Weinstein MM, Bensadoun A, Ryan RO, Fong LG, Young SG. PMID: 18340083; PMCID: PMC3055742.
      View in: PubMed   Mentions: 14     Fields:    
    141. Lipoprotein size and susceptibility to atherosclerosis--insights from genetically modified mouse models. Curr Drug Targets. 2008 Mar; 9(3):174-89. Véniant MM, Beigneux AP, Bensadoun A, Fong LG, Young SG. PMID: 18336235; PMCID: PMC3034977.
      View in: PubMed   Mentions: 14     Fields:    
    142. A potent HIV protease inhibitor, darunavir, does not inhibit ZMPSTE24 or lead to an accumulation of farnesyl-prelamin A in cells. J Biol Chem. 2008 Apr 11; 283(15):9797-804. Coffinier C, Hudon SE, Lee R, Farber EA, Nobumori C, Miner JH, Andres DA, Spielmann HP, Hrycyna CA, Fong LG, Young SG. PMID: 18230615; PMCID: PMC2442292.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    143. Eliminating the synthesis of mature lamin A reduces disease phenotypes in mice carrying a Hutchinson-Gilford progeria syndrome allele. J Biol Chem. 2008 Mar 14; 283(11):7094-9. Yang SH, Qiao X, Farber E, Chang SY, Fong LG, Young SG. PMID: 18178963.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    144. Genetic analyses of the role of RCE1 in RAS membrane association and transformation. Methods Enzymol. 2008; 438:367-89. Bergo MO, Wahlstrom AM, Fong LG, Young SG. PMID: 18413262; PMCID: PMC2386417.
      View in: PubMed   Mentions: 4     Fields:    
    145. Treatment with a farnesyltransferase inhibitor improves survival in mice with a Hutchinson-Gilford progeria syndrome mutation. Biochim Biophys Acta. 2008 Jan-Feb; 1781(1-2):36-9. Yang SH, Qiao X, Fong LG, Young SG. PMID: 18082640; PMCID: PMC2266774.
      View in: PubMed   Mentions: 45     Fields:    
    146. Normal binding of lipoprotein lipase, chylomicrons, and apo-AV to GPIHBP1 containing a G56R amino acid substitution. Biochim Biophys Acta. 2007 Dec; 1771(12):1464-8. Gin P, Beigneux AP, Davies B, Young MF, Ryan RO, Bensadoun A, Fong LG, Young SG. PMID: 17997385; PMCID: PMC2266775.
      View in: PubMed   Mentions: 14     Fields:    
    147. Increased progerin expression associated with unusual LMNA mutations causes severe progeroid syndromes. Hum Mutat. 2007 Sep; 28(9):882-9. Moulson CL, Fong LG, Gardner JM, Farber EA, Go G, Passariello A, Grange DK, Young SG, Miner JH. PMID: 17469202.
      View in: PubMed   Mentions: 50     Fields:    
    148. GPIHBP1: an endothelial cell molecule important for the lipolytic processing of chylomicrons. Curr Opin Lipidol. 2007 Aug; 18(4):389-96. Young SG, Davies BS, Fong LG, Gin P, Weinstein MM, Bensadoun A, Beigneux AP. PMID: 17620854; PMCID: PMC2888298.
      View in: PubMed   Mentions: 32     Fields:    
    149. HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells. Proc Natl Acad Sci U S A. 2007 Aug 14; 104(33):13432-7. Coffinier C, Hudon SE, Farber EA, Chang SY, Hrycyna CA, Young SG, Fong LG. PMID: 17652517; PMCID: PMC1948915.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    150. Modeling insertional mutagenesis using gene length and expression in murine embryonic stem cells. PLoS One. 2007 Jul 18; 2(7):e617. Nord AS, Vranizan K, Tingley W, Zambon AC, Hanspers K, Fong LG, Hu Y, Bacchetti P, Ferrin TE, Babbitt PC, Doniger SW, Skarnes WC, Young SG, Conklin BR. PMID: 17637833; PMCID: PMC1910612.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    151. 10 Genetic approaches to understanding the physiologic importance of the carboxyl methylation of isoprenylated proteins. Enzymes. 2006; 24:273-301. Young SG, Clarke SG, Bergoc MO, Phillips M, Fong LG. PMID: 26718044.
      View in: PubMed   Mentions: 2     Fields:    
    152. Cell nuclei spin in the absence of lamin b1. J Biol Chem. 2007 Jul 06; 282(27):20015-26. Ji JY, Lee RT, Vergnes L, Fong LG, Stewart CL, Reue K, Young SG, Zhang Q, Shanahan CM, Lammerding J. PMID: 17488709.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    153. Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons. Cell Metab. 2007 Apr; 5(4):279-91. Beigneux AP, Davies BS, Gin P, Weinstein MM, Farber E, Qiao X, Peale F, Bunting S, Walzem RL, Wong JS, Blaner WS, Ding ZM, Melford K, Wongsiriroj N, Shu X, de Sauvage F, Ryan RO, Fong LG, Bensadoun A, Young SG. PMID: 17403372; PMCID: PMC1913910.
      View in: PubMed   Mentions: 200     Fields:    
    154. Mouse models of the laminopathies. Exp Cell Res. 2007 Jun 10; 313(10):2144-56. Stewart CL, Kozlov S, Fong LG, Young SG. PMID: 17493612; PMCID: PMC1949387.
      View in: PubMed   Mentions: 48     Fields:    
    155. Prelamin A farnesylation and progeroid syndromes. J Biol Chem. 2006 Dec 29; 281(52):39741-5. Young SG, Meta M, Yang SH, Fong LG. PMID: 17090536.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    156. Protein farnesyltransferase inhibitors and progeria. Trends Mol Med. 2006 Oct; 12(10):480-7. Meta M, Yang SH, Bergo MO, Fong LG, Young SG. PMID: 16942914.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    157. LDL and cAMP cooperate to regulate the functional expression of the LRP in rat ovarian granulosa cells. J Lipid Res. 2006 Nov; 47(11):2538-50. Azhar S, Medicherla S, Shen WJ, Fujioka Y, Fong LG, Reaven E, Cooper AD. PMID: 16929031; PMCID: PMC1855269.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    158. A farnesyltransferase inhibitor improves disease phenotypes in mice with a Hutchinson-Gilford progeria syndrome mutation. J Clin Invest. 2006 Aug; 116(8):2115-21. Yang SH, Meta M, Qiao X, Frost D, Bauch J, Coffinier C, Majumdar S, Bergo MO, Young SG, Fong LG. PMID: 16862216; PMCID: PMC1513052.
      View in: PubMed   Mentions: 121     Fields:    Translation:Animals
    159. Lamins A and C but not lamin B1 regulate nuclear mechanics. J Biol Chem. 2006 Sep 01; 281(35):25768-80. Lammerding J, Fong LG, Ji JY, Reue K, Stewart CL, Young SG, Lee RT. PMID: 16825190.
      View in: PubMed   Mentions: 328     Fields:    Translation:AnimalsCells
    160. A mouse monoclonal antibody specific for mouse apoB48 and apoB100 produced by immunizing "apoB39-only" mice with mouse apoB48. Biochim Biophys Acta. 2006 Feb; 1761(2):182-5. Nguyen AT, Braschi S, Geoffrion M, Fong LG, Crooke RM, Graham MJ, Young SG, Milne R. PMID: 16551509.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCellsPHPublic Health
    161. Prelamin A and lamin A appear to be dispensable in the nuclear lamina. J Clin Invest. 2006 Mar; 116(3):743-52. Fong LG, Ng JK, Lammerding J, Vickers TA, Meta M, Coté N, Gavino B, Qiao X, Chang SY, Young SR, Yang SH, Stewart CL, Lee RT, Bennett CF, Bergo MO, Young SG. PMID: 16511604; PMCID: PMC1386109.
      View in: PubMed   Mentions: 98     Fields:    Translation:AnimalsCells
    162. A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria. Science. 2006 Mar 17; 311(5767):1621-3. Fong LG, Frost D, Meta M, Qiao X, Yang SH, Coffinier C, Young SG. PMID: 16484451.
      View in: PubMed   Mentions: 133     Fields:    Translation:AnimalsCells
    163. Prelamin A, Zmpste24, misshapen cell nuclei, and progeria--new evidence suggesting that protein farnesylation could be important for disease pathogenesis. J Lipid Res. 2005 Dec; 46(12):2531-58. Young SG, Fong LG, Michaelis S. PMID: 16207929.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansAnimalsCells
    164. Blocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes. Proc Natl Acad Sci U S A. 2005 Sep 06; 102(36):12873-8. Toth JI, Yang SH, Qiao X, Beigneux AP, Gelb MH, Moulson CL, Miner JH, Young SG, Fong LG. PMID: 16129834; PMCID: PMC1193538.
      View in: PubMed   Mentions: 126     Fields:    Translation:HumansAnimalsCells
    165. Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation. Proc Natl Acad Sci U S A. 2005 Jul 19; 102(29):10291-6. Yang SH, Bergo MO, Toth JI, Qiao X, Hu Y, Sandoval S, Meta M, Bendale P, Gelb MH, Young SG, Fong LG. PMID: 16014412; PMCID: PMC1174929.
      View in: PubMed   Mentions: 131     Fields:    Translation:AnimalsCells
    166. Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice. Proc Natl Acad Sci U S A. 2004 Dec 28; 101(52):18111-6. Fong LG, Ng JK, Meta M, Coté N, Yang SH, Stewart CL, Sullivan T, Burghardt A, Majumdar S, Reue K, Bergo MO, Young SG. PMID: 15608054; PMCID: PMC536056.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
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