Andre Nel

Title(s)Professor, Medicine
SchoolMedicine
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    Development of mRNA nanoparticles platform for treatment of peanut allergen anaphylaxis
    Found that Miller Family Foundation GiftJul 1, 2023 - Jun 30, 2025
    Role: Principal investigator
    Description: Use of peanut allergen epitopes for liver targeting by cationic lipid nanoparticles, which provide tolerogenic effects, against peanut allergen epitopes
    Therapeutic Liver-Targeting Nanoparticles for Peanut Allergy and Anaphylaxis
    CNSI Noble Innovation Fund Committee Noble Innovation FundAug 1, 2021 - Jul 31, 2023
    Role: Co-PI
    Description: Development of a tolerogenic liver-targeting nanoparticles for the treatment of peanut anaphylaxis
    Development of Therapeutic Liver Targeting Nanoparticles for Treatment of Food Allergen Anaphylaxis
    Foundation Miller Family Foundation GiftApr 1, 2021 - Mar 31, 2024
    Role: Principal investigator
    Description: Use of a liver targeting nanoparticles for the treatment of ovalbumin and peanut anaphylaxis
    Use of a Nano-Enabled Platform for Pancreatic Cancer Immunotherapy
    NIH R01CA247666Jul 1, 2020 - Jun 30, 2025
    Role: Principal Investigator
    Liver Targeting Tolerogenic Nanoparticles for the Treatment of Peanut Allergy
    UCLA Clinical and Translational Science Institute (Intramural Award) NIH UL1TR001881Dec 1, 2019 - Jun 30, 2021
    Role: Principal investigator
    Tolerogenic Nanoparticles for the Treatment of Allergy and Autoimmune Disorders
    UCLA Clinical and Translational Science Institute (Intramural Award) NIH UL1TR001881Oct 1, 2019 - Jun 30, 2021
    Role: Principal investigator
    Description: Development of liver targeting polymer nanoparticles for delivering of allergens and autoimmune antigens
    Upscale Manufacturing Silicasomes for Clinical Trial Development
    Westwood BiosciencesWestwood Biosciences 20180178 UCLA SRA Westwood Biosciences 20180178Aug 14, 2017 - Aug 13, 2020
    Role: Principal investigator
    Description: SRA, to develop upscale synthesis of a nanocarrier
    Toxicological Profiling of Engineered Nanomaterials (ENMs) in the MPS (RES)
    NIH U01ES027237Sep 1, 2016 - Aug 31, 2021
    Role: Principal Investigator
    UCLA Multifunctional Mesoporous Silica Nanoparticle Platform for Treatment of Pancreas Cancer
    NIH U01CA198846Sep 25, 2015 - Jul 31, 2021
    Role: Principal Investigator
    Understanding the Sorption Characteristics of III-V Materials on CMP Nanoparticles and Evaluate their Environmental Impact Using the Zebrafish Model
    Semiconductor Research Corporation SRC 2001-MC-425Jan 1, 2015 - Dec 31, 2019
    Role: Principal investigator
    Description: The study of the toxicity of slurry material nanoparticles from the publishing of semiconductor wafers
    Carbon Nanotube Structure-Activity Relationships for Predictive Toxicology
    NIH R01ES022698Dec 9, 2013 - Oct 31, 2019
    Role: Principal Investigator
    UC Center for Environmental Implications of Nanotechnology
    NSF/EPA NSF and EPA Cooperative Agreement (DBI-1266377)Sep 1, 2013 - Aug 31, 2020
    Role: Principal investigator
    Description: Nanotechnology environmental health and safety
    Predictive Toxicology Paradigm for Chronic Nanoparticle Injury in the Lung
    NIH NIEHS R01 ES916746Aug 15, 2013 - Mar 31, 2018
    Role: Principal investigator
    Description: Nanoparticles toxicity in the lung
    Center for Nanobiology and Predictive Toxicology
    NIH U19ES019528Sep 24, 2010 - Apr 30, 2016
    Role: Principal Investigator
    Nanovalve Platform: Targeted, Controlled, Release of Anticancer Drugs
    NIH R01CA133697Jan 1, 2010 - Jun 30, 2015
    Role: Co-Principal Investigator
    Predictive Toxicological Paradigms to Establish Inhalation Toxicology Models
    NIH RC2ES018766Sep 30, 2009 - Jun 30, 2012
    Role: Principal Investigator
    UC Center for the Environmental Implications of Nanotechnology (CEIN)
    NSF/EPA NSF and EPA Cooperative Agreement (DBI - 0830117).Aug 10, 2008 - Aug 31, 2015
    Role: Principal investigator
    Description: Nanotechnology environmental health and safety research
    Predictive Toxicological Paradigm for Chronic Nanoparticle Injury in the Lung
    NIH R01ES016746May 15, 2008 - Feb 29, 2020
    Role: Principal Investigator
    Nano-Biological Interactions and Toxicity of Engineered Metal Oxide Particles
    NIH NIEHS R01 ES016746May 15, 2008 - Aug 14, 2013
    Role: Principal investigator
    Description: Assessment of metal oxide nanoparticles toxicity at the nano/bio interface
    Nanovalve Platform: Targeted, Controlled, Release of Anticancer Drugs
    NIH NCI R01 CA133697Apr 1, 2008 - Jun 30, 2015
    Role: Multi-PI
    Description: Multifunctional mesoporous silica nanoparticles with controllable mechanisms
    Development of methods and models for nanoparticle toxicity screening: Applicatio
    NIH R01ES015498Sep 30, 2006 - Jun 30, 2009
    Role: Principal Investigator
    Development of Methods and Models for Nanoparticle Toxicity Screening
    NIH NIEHS R0-1 ES015498-01Sep 1, 2006 - Aug 30, 2009
    Role: Principal investigator
    Description: Toxicological methods for screening of nanoparticles toxicity
    Xenobiotics, Oxidative Stress and Allergic Inflammation
    NIH U19AI070453Jul 15, 2006 - Jun 30, 2012
    Role: Principal Investigator
    Xenobiotics, Oxidative Stress and Allergic Inflammation
    NIAID-funded Asthma and Allergic Diseases Cooperative Research Centers (AADCRC) U19 AI070453-01Jul 1, 2006 - Jun 30, 2011
    Role: Principal investigator
    Description: The role of diesel exhaust particles in promoting allergic inflammation
    UC Lead Campus Program for Nanotoxicology Research and Training
    UC Toxic Substances Research Program UC TSRP UC Lead Campus for Toxic Substances ResearJul 1, 2006 - Jun 30, 2011
    Role: Principal investigator
    Description: UCLA and UCSB research program for assessment of nanomaterial safety
    Southern California Center for Airborne Particulate Matter
    EPA EPA-STAR AWARD RD-83241301Oct 1, 2005 - Sep 30, 2011
    Role: Co-PI and project leader: Role of Oxidative Stress in the Susceptibility to PM-Induced Adverse Healt
    Atherogenic Effects of Ambient PM In Susceptible Animals
    NIH R01ES013432Sep 1, 2004 - Jul 31, 2010
    Role: Principal Investigator
    Proteomics of DEP-induced Oxidative Stress
    NIH R01ES012053Sep 10, 2002 - Jul 31, 2008
    Role: Principal Investigator
    Biological Analysis of Toxic DEP Chemicals
    NIH R01ES010553Feb 21, 2002 - Nov 30, 2008
    Role: Principal Investigator
    Southern California Center for Airborne Particulate Matter
    EPA EPA-STAR AWARDJun 1, 1999 - Jun 1, 2005
    Role: Project Leader: Effects of PAH and Redox-active Quinones in Particles on Allergic Inflammation
    Description: Particulate matter composition and health effects in relation to freeways
    Lipids rafts in JNK and Nk-kB activation by TCR/CD28
    NIH R01AG014992Aug 1, 1998 - Apr 30, 2010
    Role: Principal Investigator
    Xenobiotics and Allergic Inflammation
    NIH NIAID Asthma and Immunology Center PO-1 AI-34567Sep 1, 1997 - Aug 31, 2001
    Role: Project leader: Xenobiotic Effects on Allergic Responses via Macrophages
    Description: Study of the role of peer pollution particles, on asthma
    MAPK CASCADES AND FUNCTION DECLINE OF AGED T CELLS
    NIH R03AG014763Aug 1, 1997 - Jul 31, 1999
    Role: Principal Investigator
    Role of MAPK Cascades in Function Decline of Aged T-cells
    NIH NIA RO3 AG14763Aug 1, 1997 - Jul 31, 1998
    Role: Principal investigator
    Description: Impact of of aging on signaling by the TCR
    CYTOKINE AND GROWTH FACTOR PATHWAYS IN KAPOSIS SARCOMA
    NIH R01CA065329Jul 1, 1994 - Apr 30, 2000
    Role: Principal Investigator
    Molecular Regulation of Allergic-Immune Inflammation
    NIH NIAID PO1 AI-34567 Program Project (Asthma)Sep 1, 1993 - Aug 31, 1997
    Role: Co-PI
    Description: Program project on asthma and allergic inflammation
    Oncostatin M Signaling Pathways in Kaposi’s Sarcoma
    American Federation for Aids Research AmFAR 02104-15-RGJul 1, 1993 - Jun 30, 1994
    Role: Principal investigator
    IBD: Genetic and Immunopathologic Mechanisms
    NIH NIH/NIDDK DK-44482Sep 1, 1992 - Aug 31, 1995
    Role: PI for Project 3: A.E. Nel
    Description: A study of the Immunology and genetic predisposition to inflammatory thou disease
    Utility of a Signal Integrating Kinase in Studying T-cell Activation
    Concern Foundation of Los Angeles B911206Jan 1, 1992 - Dec 31, 1992
    CD4 Cell Inhibition by CD4-Receptor and HIV Envelope Peptides
    UC Systemwide Task Force on AIDS R89LA089Jul 1, 1989 - Jun 30, 1991
    Role: Principal investigator
    Description: Impact of HIV envelope protein on signaling via the TCR
    PKC AND TYROSINE KINASES SYNERGIZE IN T-CELL ACTIVATION
    NIH R01GM041576Sep 1, 1988 - Mar 31, 1997
    Role: Principal Investigator
    Center for Interdisciplinary Research in Immunology and Disease
    NIH NIAID AI-15332Sep 1, 1988 - Aug 31, 1993
    Role: Project leader
    Description: Immunology center for the study of the role of imunology in disease
    ALLERGY, IMMUNOLOGY &TRANSPLANTATION RESEARCH COMMITTEE
    NIH U09AI023260Jul 1, 1985 - Jun 30, 2006
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Reprogramming the Tolerogenic Immune Response Against Pancreatic Cancer Metastases by Lipid Nanoparticles Delivering a STING Agonist Plus Mutant KRAS mRNA. ACS Nano. 2025 Mar 11; 19(9):8579-8594. Xu X, Wang X, Liao YP, Luo L, Nel AE. PMID: 40025875; PMCID: PMC11912578.
      View in: PubMed   Mentions:
    2. Correction to "Surface Oxidation of Graphene Oxide Determines Membrane Damage, Lipid Peroxidation, and Cytotoxicity in Macrophages in a Pulmonary Toxicity Model". ACS Nano. 2024 Dec 17; 18(50):34423. Li R, Guiney LM, Chang CH, Mansukhani ND, Ji Z, Wang X, Liao YP, Jiang W, Sun B, Hersam MC, Nel AE, Xia T. PMID: 39626266.
      View in: PubMed   Mentions:    Fields:    
    3. The Interplay Between the Immune System, Tumor Suppressor Genes, and Immune Senescence in Mesothelioma Development and Response to Immunotherapy. J Thorac Oncol. 2024 Apr; 19(4):551-564. Nel AE, Pavlisko EN, Roggli VL. PMID: 38000500.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    4. Reprogramming the pancreatic cancer stroma and immune landscape by a silicasome nanocarrier delivering nintedanib, a protein tyrosine kinase inhibitor. Nano Today. 2024 Feb; 54. Luo L, Wang X, Liao YP, Xu X, Chang CH, Nel AE. PMID: 38681872; PMCID: PMC11044875.
      View in: PubMed   Mentions:
    5. Correction to "Nanocarrier Co-formulation for Delivery of a TLR7 Agonist plus an Immunogenic Cell Death Stimulus Triggers Effective Pancreatic Cancer Chemo-immunotherapy". ACS Nano. 2023 Aug 08; 17(15):15216. Luo L, Wang X, Liao YP, Chang CH, Nel AE. PMID: 37504218.
      View in: PubMed   Mentions:    Fields:    
    6. Non-asbestiform elongate mineral particles and mesothelioma risk: Human and experimental evidence. Environ Res. 2023 08 01; 230:114578. Goodman JE, Becich MJ, Bernstein DM, Case BW, Mandel JH, Nel AE, Nolan R, Odo NU, Smith SR, Taioli E, Gibbs G. PMID: 36965797; PMCID: PMC11225580.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    7. Carbon nanotube pathogenicity conforms to a unified theory for mesothelioma causation by elongate materials and fibers. Environ Res. 2023 08 01; 230:114580. Nel A. PMID: 36965801.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    8. Use of a Liver-Targeting Immune-Tolerogenic mRNA Lipid Nanoparticle Platform to Treat Peanut-Induced Anaphylaxis by Single- and Multiple-Epitope Nucleotide Sequence Delivery. ACS Nano. 2023 03 14; 17(5):4942-4957. Xu X, Wang X, Liao YP, Luo L, Xia T, Nel AE. PMID: 36853930; PMCID: PMC10019335.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    9. Publishing Translational Research of Nanomedicine in ACS Nano. ACS Nano. 2022 11 22; 16(11):17479-17481. Hu T, Brinker CJ, Chan WCW, Chen C, Chen X, Ho D, Kataoka K, Kotov NA, Liz-Marzán LM, Nel AE, Parak WJ, Stevens M. PMID: 36440801.
      View in: PubMed   Mentions: 9     Fields:    
    10. Nanocarrier Co-formulation for Delivery of a TLR7 Agonist plus an Immunogenic Cell Death Stimulus Triggers Effective Pancreatic Cancer Chemo-immunotherapy. ACS Nano. 2022 08 23; 16(8):13168-13182. Luo L, Wang X, Liao YP, Chang CH, Nel AE. PMID: 35920660; PMCID: PMC10117630.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    11. Tanks and Truth. ACS Nano. 2022 04 26; 16(4):4975-4976. Kotov NA, Akinwande D, Brinker CJ, Buriak JM, Chan WCW, Chen X, Chhowalla M, Chueh W, Glotzer SC, Gogotsi Y, Hersam MC, Ho D, Hu T, Javey A, Kagan CR, Kataoka K, Kim ID, Lee ST, Lee YH, Liz-Marzán LM, Millstone JE, Mulvaney P, Nel AE, Nordlander P, Parak WJ, Penner RM, Rogach AL, Salanne M, Schaak RE, Sood AK, Stevens M, Tsukruk V, Wee ATS, Voets I, Weil T, Weiss PS. PMID: 35315638.
      View in: PubMed   Mentions:    Fields:    
    12. Use of a Liver-targeting Nanoparticle Platform to Intervene in Peanut-induced anaphylaxis through delivery of an Ara h2 T-cell Epitope. Nano Today. 2022 Feb; 42. Liu Q, Wang X, Liao YP, Chang CH, Li J, Xia T, Nel AE. PMID: 36969911; PMCID: PMC10038170.
      View in: PubMed   Mentions: 8  
    13. Retraction of "Breast Cancer Chemo-immunotherapy through Liposomal Delivery of an Immunogenic Cell Death Stimulus Plus Interference in the IDO-1 Pathway". ACS Nano. 2021 Jun 22; 15(6):10735. Lu J, Liu X, Liao YP, Wang X, Ahmed A, Jiang W, Ji Y, Meng H, Nel AE. PMID: 34018715; PMCID: PMC8887877.
      View in: PubMed   Mentions: 1     Fields:    
    14. Development of Facile and Versatile Platinum Drug Delivering Silicasome Nanocarriers for Efficient Pancreatic Cancer Chemo-Immunotherapy. Small. 2021 04; 17(14):e2005993. Liu X, Jiang J, Chang CH, Liao YP, Lodico JJ, Tang I, Zheng E, Qiu W, Lin M, Wang X, Ji Y, Mei KC, Nel AE, Meng H. PMID: 33682329; PMCID: PMC8035264.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    15. Combination Chemo-Immunotherapy for Pancreatic Cancer Using the Immunogenic Effects of an Irinotecan Silicasome Nanocarrier Plus Anti-PD-1. Adv Sci (Weinh). 2021 Mar; 8(6):2002147. Liu X, Jiang J, Liao YP, Tang I, Zheng E, Qiu W, Lin M, Wang X, Ji Y, Mei KC, Liu Q, Chang CH, Wainberg ZA, Nel AE, Meng H. PMID: 33747719; PMCID: PMC7967046.
      View in: PubMed   Mentions: 27     Fields:    
    16. Immune checkpoint inhibition in syngeneic mouse cancer models by a silicasome nanocarrier delivering a GSK3 inhibitor. Biomaterials. 2021 02; 269:120635. Allen SD, Liu X, Jiang J, Liao YP, Chang CH, Nel AE, Meng H. PMID: 33422940; PMCID: PMC7870571.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    17. Antigen- and Epitope-Delivering Nanoparticles Targeting Liver Induce Comparable Immunotolerance in Allergic Airway Disease and Anaphylaxis as Nanoparticle-Delivering Pharmaceuticals. ACS Nano. 2021 01 26; 15(1):1608-1626. Liu Q, Wang X, Liu X, Liao YP, Chang CH, Mei KC, Jiang J, Tseng S, Gochman G, Huang M, Thatcher Z, Li J, Allen SD, Lucido L, Xia T, Nel AE. PMID: 33351586; PMCID: PMC7943028.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    18. Liposomal Delivery of Mitoxantrone and a Cholesteryl Indoximod Prodrug Provides Effective Chemo-immunotherapy in Multiple Solid Tumors. ACS Nano. 2020 10 27; 14(10):13343-13366. Mei KC, Liao YP, Jiang J, Chiang M, Khazaieli M, Liu X, Wang X, Liu Q, Chang CH, Zhang X, Li J, Ji Y, Melano B, Telesca D, Xia T, Meng H, Nel AE. PMID: 32940463; PMCID: PMC8023019.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    19. Nano as a Rosetta Stone: The Global Roles and Opportunities for Nanoscience and Nanotechnology. ACS Nano. 2019 10 22; 13(10):10853-10855. Zhao Y, Bai C, Brinker CJ, Chi L, Dawson KA, Gogotsi Y, Halas NJ, Lee ST, Lee T, Liz-Marzán L, Miller JF, Mitra S, Nel AE, Nordlander P, Parak WJ, Rowan A, Rogach AL, Rotello VM, Tang BZ, Wee ATS, Weiss PS. PMID: 31683413.
      View in: PubMed   Mentions: 2     Fields:    
    20. IL-4 subverts mycobacterial containment in Mycobacterium tuberculosis-infected human macrophages. Eur Respir J. 2019 08; 54(2). Pooran A, Davids M, Nel A, Shoko A, Blackburn J, Dheda K. PMID: 31097521.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    21. Nanoscience and Nanotechnology at UCLA. ACS Nano. 2019 06 25; 13(6):6127-6129. Khademhosseini A, Nel AE, Bunje H, DeSantis CJ, Andrews AM, Blaik RA, Gu Z, Meng H, Ozcan A, Tolbert SH, Xia T, Zink JI, Weiss PS. PMID: 31247733.
      View in: PubMed   Mentions:    Fields:    
    22. Use of Polymeric Nanoparticle Platform Targeting the Liver To Induce Treg-Mediated Antigen-Specific Immune Tolerance in a Pulmonary Allergen Sensitization Model. ACS Nano. 2019 04 23; 13(4):4778-4794. Liu Q, Wang X, Liu X, Kumar S, Gochman G, Ji Y, Liao YP, Chang CH, Situ W, Lu J, Jiang J, Mei KC, Meng H, Xia T, Nel AE. PMID: 30964276; PMCID: PMC6506187.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    23. Impact of weather and climate change with indoor and outdoor air quality in asthma: A Work Group Report of the AAAAI Environmental Exposure and Respiratory Health Committee. J Allergy Clin Immunol. 2019 05; 143(5):1702-1710. Poole JA, Barnes CS, Demain JG, Bernstein JA, Padukudru MA, Sheehan WJ, Fogelbach GG, Wedner J, Codina R, Levetin E, Cohn JR, Kagen S, Portnoy JM, Nel AE. PMID: 30826366; PMCID: PMC10907958.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansPHPublic Health
    24. Improved Efficacy and Reduced Toxicity Using a Custom-Designed Irinotecan-Delivering Silicasome for Orthotopic Colon Cancer. ACS Nano. 2019 01 22; 13(1):38-53. Liu X, Jiang J, Chan R, Ji Y, Lu J, Liao YP, Okene M, Lin J, Lin P, Chang CH, Wang X, Tang I, Zheng E, Qiu W, Wainberg ZA, Nel AE, Meng H. PMID: 30525443; PMCID: PMC6554030.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    25. Breast Cancer Chemo-immunotherapy through Liposomal Delivery of an Immunogenic Cell Death Stimulus Plus Interference in the IDO-1 Pathway. ACS Nano. 2018 11 27; 12(11):11041-11061. Lu J, Liu X, Liao YP, Wang X, Ahmed A, Jiang W, Ji Y, Meng H, Nel AE. PMID: 30481959; PMCID: PMC6262474.
      View in: PubMed   Mentions: 83     Fields:    Translation:AnimalsCells
    26. Use of nano engineered approaches to overcome the stromal barrier in pancreatic cancer. Adv Drug Deliv Rev. 2018 05; 130:50-57. Meng H, Nel AE. PMID: 29958925; PMCID: PMC6554022.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    27. Helmuth Möhwald (1946-2018). ACS Nano. 2018 Apr 24; 12(4):3053-3055. Parak WJ, Chan WWC, Chhowalla M, Farokhzad O, Glotzer S, Gogotsi Y, Hammond PT, Hersam MC, Javey A, Kagan CR, Kataoka K, Khademhosseini A, Kotov NA, Lee ST, Lee YH, Li Y, Millstone J, Mulvaney PA, Nel AE, Nordlander PJ, Penner RM, Rogach AL, Schaak RE, Stevens MM, Wee ATS, Willson CG, Weiss PS. PMID: 29676563.
      View in: PubMed   Mentions:    Fields:    
    28. Surface Oxidation of Graphene Oxide Determines Membrane Damage, Lipid Peroxidation, and Cytotoxicity in Macrophages in a Pulmonary Toxicity Model. ACS Nano. 2018 02 27; 12(2):1390-1402. Li R, Guiney LM, Chang CH, Mansukhani ND, Ji Z, Wang X, Liao YP, Jiang W, Sun B, Hersam MC, Nel AE, Xia T. PMID: 29328670; PMCID: PMC5834379.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    29. Nanotechnology Strategies To Advance Outcomes in Clinical Cancer Care. ACS Nano. 2018 01 23; 12(1):24-43. Hartshorn CM, Bradbury MS, Lanza GM, Nel AE, Rao J, Wang AZ, Wiesner UB, Yang L, Grodzinski P. PMID: 29257865; PMCID: PMC6589353.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimals
    30. Nano-enabled pancreas cancer immunotherapy using immunogenic cell death and reversing immunosuppression. Nat Commun. 2017 11 27; 8(1):1811. Lu J, Liu X, Liao YP, Salazar F, Sun B, Jiang W, Chang CH, Jiang J, Wang X, Wu AM, Meng H, Nel AE. PMID: 29180759; PMCID: PMC5703845.
      View in: PubMed   Mentions: 147     Fields:    Translation:HumansAnimalsCells
    31. Our First and Next Decades at ACS Nano. ACS Nano. 2017 08 22; 11(8):7553-7555. Chan WCW, Chhowalla M, Glotzer S, Gogotsi Y, Hafner JH, Hammond PT, Hersam MC, Javey A, Kagan CR, Kataoka K, Khademhosseini A, Kotov NA, Lee ST, Li Y, Möhwald H, Mulvaney P, Nel AE, Nordlander PJ, Parak WJ, Penner RM, Rogach AL, Schaak RE, Stevens MM, Wee ATS, Willson CG, Fernandez LE, Weiss PS. PMID: 28830059.
      View in: PubMed   Mentions:    Fields:    
    32. Major effect of transcytosis on nano drug delivery to pancreatic cancer. Mol Cell Oncol. 2017; 4(4):e1335273. Liu X, Jiang J, Nel AE, Meng H. PMID: 28868347; PMCID: PMC5540216.
      View in: PubMed   Mentions: 5  
    33. Advancing alternatives analysis: The role of predictive toxicology in selecting safer chemical products and processes. Integr Environ Assess Manag. 2017 Sep; 13(5):915-925. Malloy T, Zaunbrecher V, Beryt E, Judson R, Tice R, Allard P, Blake A, Cote I, Godwin H, Heine L, Kerzic P, Kostal J, Marchant G, McPartland J, Moran K, Nel A, Ogunseitan O, Rossi M, Thayer K, Tickner J, Whittaker M, Zarker K. PMID: 28247928.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    34. Tumor-penetrating peptide enhances transcytosis of silicasome-based chemotherapy for pancreatic cancer. J Clin Invest. 2017 May 01; 127(5):2007-2018. Liu X, Lin P, Perrett I, Lin J, Liao YP, Chang CH, Jiang J, Wu N, Donahue T, Wainberg Z, Nel AE, Meng H. PMID: 28414297; PMCID: PMC5409788.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimals
    35. Diverse Applications of Nanomedicine. ACS Nano. 2017 03 28; 11(3):2313-2381. Pelaz B, Alexiou C, Alvarez-Puebla RA, Alves F, Andrews AM, Ashraf S, Balogh LP, Ballerini L, Bestetti A, Brendel C, Bosi S, Carril M, Chan WC, Chen C, Chen X, Chen X, Cheng Z, Cui D, Du J, Dullin C, Escudero A, Feliu N, Gao M, George M, Gogotsi Y, Grünweller A, Gu Z, Halas NJ, Hampp N, Hartmann RK, Hersam MC, Hunziker P, Jian J, Jiang X, Jungebluth P, Kadhiresan P, Kataoka K, Khademhosseini A, Kopecek J, Kotov NA, Krug HF, Lee DS, Lehr CM, Leong KW, Liang XJ, Ling Lim M, Liz-Marzán LM, Ma X, Macchiarini P, Meng H, Möhwald H, Mulvaney P, Nel AE, Nie S, Nordlander P, Okano T, Oliveira J, Park TH, Penner RM, Prato M, Puntes V, Rotello VM, Samarakoon A, Schaak RE, Shen Y, Sjöqvist S, Skirtach AG, Soliman MG, Stevens MM, Sung HW, Tang BZ, Tietze R, Udugama BN, VanEpps JS, Weil T, Weiss PS, Willner I, Wu Y, Yang L, Yue Z, Zhang Q, Zhang Q, Zhang XE, Zhao Y, Zhou X, Parak WJ. PMID: 28290206; PMCID: PMC5371978.
      View in: PubMed   Mentions: 336     Fields:    Translation:HumansAnimals
    36. Policy reforms to update chemical safety testing. Science. 2017 Mar 10; 355(6329):1016-1018. Nel AE, Malloy TF. PMID: 28280165.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    37. Nanoscience and Nanotechnology Cross Borders. ACS Nano. 2017 02 28; 11(2):1123-1126. Khademhosseini A, Chan WW, Chhowalla M, Glotzer SC, Gogotsi Y, Hafner JH, Hammond PT, Hersam MC, Javey A, Kagan CR, Kotov NA, Lee ST, Li Y, Möhwald H, Mulvaney PA, Nel AE, Parak WJ, Penner RM, Rogach AL, Schaak RE, Stevens MM, Wee AT, Brinker J, Chen X, Chi L, Crommie M, Dekker C, Farokhzad O, Gerber C, Ginger DS, Irvine DJ, Kiessling LL, Kostarelos K, Landes C, Lee T, Leggett GJ, Liang XJ, Liz-Marzán L, Millstone J, Odom TW, Ozcan A, Prato M, Rao CN, Sailor MJ, Weiss E, Weiss PS. PMID: 28199099.
      View in: PubMed   Mentions:    Fields:    
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    45. Evaluation of Toxicity Ranking for Metal Oxide Nanoparticles via an in Vitro Dosimetry Model. ACS Nano. 2015 Sep 22; 9(9):9303-13. Liu R, Liu HH, Ji Z, Chang CH, Xia T, Nel AE, Cohen Y. PMID: 26284985.
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    50. Use of a lipid-coated mesoporous silica nanoparticle platform for synergistic gemcitabine and paclitaxel delivery to human pancreatic cancer in mice. ACS Nano. 2015; 9(4):3540-57. Meng H, Wang M, Liu H, Liu X, Situ A, Wu B, Ji Z, Chang CH, Nel AE. PMID: 25776964; PMCID: PMC4415452.
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    55. Interference in autophagosome fusion by rare earth nanoparticles disrupts autophagic flux and regulation of an interleukin-1β producing inflammasome. ACS Nano. 2014 Oct 28; 8(10):10280-92. Li R, Ji Z, Qin H, Kang X, Sun B, Wang M, Chang CH, Wang X, Zhang H, Zou H, Nel AE, Xia T. PMID: 25251502; PMCID: PMC4213039.
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    58. Sulforaphane-rich broccoli sprout extract attenuates nasal allergic response to diesel exhaust particles. Food Funct. 2014 Jan; 5(1):35-41. Heber D, Li Z, Garcia-Lloret M, Wong AM, Lee TY, Thames G, Krak M, Zhang Y, Nel A. PMID: 24287881; PMCID: PMC8754169.
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    61. Nanocenter directors gather from around the world. ACS Nano. 2013 Sep 24; 7(9):7437-8. Mulvaney P, Nel AE, Rogach A, Weiss PS. PMID: 24490873.
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    66. Codelivery of an optimal drug/siRNA combination using mesoporous silica nanoparticles to overcome drug resistance in breast cancer in vitro and in vivo. ACS Nano. 2013 Feb 26; 7(2):994-1005. Meng H, Mai WX, Zhang H, Xue M, Xia T, Lin S, Wang X, Zhao Y, Ji Z, Zink JI, Nel AE. PMID: 23289892; PMCID: PMC3620006.
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    67. Real-time electrical detection of nitric oxide in biological systems with sub-nanomolar sensitivity. Nat Commun. 2013; 4:2225. Jiang S, Cheng R, Wang X, Xue T, Liu Y, Nel A, Huang Y, Duan X. PMID: 23887829.
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    74. Targeted intracellular delivery of antituberculosis drugs to Mycobacterium tuberculosis-infected macrophages via functionalized mesoporous silica nanoparticles. Antimicrob Agents Chemother. 2012 May; 56(5):2535-45. Clemens DL, Lee BY, Xue M, Thomas CR, Meng H, Ferris D, Nel AE, Zink JI, Horwitz MA. PMID: 22354311; PMCID: PMC3346638.
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    75. Development of Pharmaceutically Adapted Mesoporous Silica Nanoparticles Platform. J Phys Chem Lett. 2012 Feb 02; 3(3):358-9. Meng H, Xue M, Zink JI, Nel AE. PMID: 26285851.
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    77. Feasibility of biomarker studies for engineered nanoparticles: what can be learned from air pollution research. J Occup Environ Med. 2011 Jun; 53(6 Suppl):S74-9. Li N, Nel AE. PMID: 21654422; PMCID: PMC3163229.
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    81. Nanomaterials in the environment: from materials to high-throughput screening to organisms. ACS Nano. 2011 Jan 25; 5(1):13-20. Thomas CR, George S, Horst AM, Ji Z, Miller RJ, Peralta-Videa JR, Xia T, Pokhrel S, Mädler L, Gardea-Torresdey JL, Holden PA, Keller AA, Lenihan HS, Nel AE, Zink JI. PMID: 21261306.
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    101. Innate immune responses during respiratory tract infection with a bacterial pathogen induce allergic airway sensitization. J Allergy Clin Immunol. 2008 Sep; 122(3):595-602.e5. Schröder NW, Crother TR, Naiki Y, Chen S, Wong MH, Yilmaz A, Slepenkin A, Schulte D, Alsabeh R, Doherty TM, Peterson E, Nel AE, Arditi M. PMID: 18774395; PMCID: PMC3052793.
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    102. Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery. ACS Nano. 2008 May; 2(5):889-96. Liong M, Lu J, Kovochich M, Xia T, Ruehm SG, Nel AE, Tamanoi F, Zink JI. PMID: 19206485; PMCID: PMC2751731.
      View in: PubMed   Mentions: 320     Fields:    Translation:Cells
    103. T-cell effector pathways in allergic diseases: transcriptional mechanisms and therapeutic targets. J Allergy Clin Immunol. 2008 Apr; 121(4):812-23; quiz 824-5. Chatila TA, Li N, Garcia-Lloret M, Kim HJ, Nel AE. PMID: 18395547.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    104. Nrf2 activation by sulforaphane restores the age-related decrease of T(H)1 immunity: role of dendritic cells. J Allergy Clin Immunol. 2008 May; 121(5):1255-1261.e7. Kim HJ, Barajas B, Wang M, Nel AE. PMID: 18325578; PMCID: PMC3897785.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    105. The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles. Free Radic Biol Med. 2008 May 01; 44(9):1689-99. Li N, Xia T, Nel AE. PMID: 18313407; PMCID: PMC2387181.
      View in: PubMed   Mentions: 241     Fields:    Translation:HumansAnimalsCells
    106. Importance of oxidative stress in the pathogenesis and treatment of asthma. Curr Opin Allergy Clin Immunol. 2008 Feb; 8(1):49-56. Riedl MA, Nel AE. PMID: 18188018.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansAnimalsCells
    107. Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress. Circ Res. 2008 Mar 14; 102(5):589-96. Araujo JA, Barajas B, Kleinman M, Wang X, Bennett BJ, Gong KW, Navab M, Harkema J, Sioutas C, Lusis AJ, Nel AE. PMID: 18202315; PMCID: PMC3014059.
      View in: PubMed   Mentions: 215     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    108. Cationic polystyrene nanosphere toxicity depends on cell-specific endocytic and mitochondrial injury pathways. ACS Nano. 2008 Jan; 2(1):85-96. Xia T, Kovochich M, Liong M, Zink JI, Nel AE. PMID: 19206551.
      View in: PubMed   Mentions: 182     Fields:    Translation:HumansAnimalsCells
    109. Pro-oxidative DEP chemicals induce heat shock proteins and an unfolding protein response in a bronchial epithelial cell line as determined by DIGE analysis. Proteomics. 2007 Nov; 7(21):3906-18. Jung EJ, Avliyakulov NK, Boontheung P, Loo JA, Nel AE. PMID: 17922515.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    110. Part II: coordinated biosensors--development of enhanced nanobiosensors for biological and medical applications. Nanomedicine (Lond). 2007 Oct; 2(5):599-614. Shi H, Xia T, Nel AE, Yeh JI. PMID: 17976023.
      View in: PubMed   Mentions: 5     Fields:    
    111. Mesoporous Silica Nanoparticles for Cancer Therapy: Energy-Dependent Cellular Uptake and Delivery of Paclitaxel to Cancer Cells. Nanobiotechnology. 2007 May 01; 3(2):89-95. Lu J, Liong M, Sherman S, Xia T, Kovochich M, Nel AE, Zink JI, Tamanoi F. PMID: 19936038; PMCID: PMC2779038.
      View in: PubMed   Mentions: 53  
    112. Glutathione depletion inhibits dendritic cell maturation and delayed-type hypersensitivity: implications for systemic disease and immunosenescence. J Allergy Clin Immunol. 2007 May; 119(5):1225-33. Kim HJ, Barajas B, Chan RC, Nel AE. PMID: 17335885.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    113. Impairment of mitochondrial function by particulate matter (PM) and their toxic components: implications for PM-induced cardiovascular and lung disease. Front Biosci. 2007 Jan 01; 12:1238-46. Xia T, Kovochich M, Nel AE. PMID: 17127377.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    114. Air-pollutant chemicals and oxidized lipids exhibit genome-wide synergistic effects on endothelial cells. Genome Biol. 2007; 8(7):R149. Gong KW, Zhao W, Li N, Barajas B, Kleinman M, Sioutas C, Horvath S, Lusis AJ, Nel A, Araujo JA. PMID: 17655762; PMCID: PMC2323217.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    115. Pro-oxidative diesel exhaust particle chemicals inhibit LPS-induced dendritic cell responses involved in T-helper differentiation. J Allergy Clin Immunol. 2006 Aug; 118(2):455-65. Chan RC, Wang M, Li N, Yanagawa Y, Onoé K, Lee JJ, Nel AE. PMID: 16890772.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    116. Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm. Nano Lett. 2006 Aug; 6(8):1794-807. Xia T, Kovochich M, Brant J, Hotze M, Sempf J, Oberley T, Sioutas C, Yeh JI, Wiesner MR, Nel AE. PMID: 16895376.
      View in: PubMed   Mentions: 392     Fields:    Translation:AnimalsCells
    117. Tracheobronchial particle dose considerations for in vitro toxicology studies. Toxicol Sci. 2006 Jul; 92(1):126-32. Phalen RF, Oldham MJ, Nel AE. PMID: 16597657.
      View in: PubMed   Mentions: 21     Fields:    
    118. How exposure to environmental tobacco smoke, outdoor air pollutants, and increased pollen burdens influences the incidence of asthma. Environ Health Perspect. 2006 Apr; 114(4):627-33. Gilmour MI, Jaakkola MS, London SJ, Nel AE, Rogers CA. PMID: 16581557; PMCID: PMC1440792.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansPHPublic Health
    119. Toxic potential of materials at the nanolevel. Science. 2006 Feb 03; 311(5761):622-7. Nel A, Xia T, Mädler L, Li N. PMID: 16456071.
      View in: PubMed   Mentions: 1675     Fields:    Translation:HumansAnimalsPHPublic Health
    120. Role of the Nrf2-mediated signaling pathway as a negative regulator of inflammation: implications for the impact of particulate pollutants on asthma. Antioxid Redox Signal. 2006 Jan-Feb; 8(1-2):88-98. Li N, Nel AE. PMID: 16487041.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    121. The role of reactive oxygen species and oxidative stress in mediating particulate matter injury. Clin Occup Environ Med. 2006; 5(4):817-36. Xia T, Kovochich M, Nel A. PMID: 17110294.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansPHPublic Health
    122. The role of phase II antioxidant enzymes in protecting memory T cells from spontaneous apoptosis in young and old mice. J Immunol. 2005 Sep 01; 175(5):2948-59. Kim HJ, Nel AE. PMID: 16116181.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    123. Use of a fluorescent phosphoprotein dye to characterize oxidative stress-induced signaling pathway components in macrophage and epithelial cultures exposed to diesel exhaust particle chemicals. Electrophoresis. 2005 Jun; 26(11):2092-108. Wang M, Xiao GG, Li N, Xie Y, Loo JA, Nel AE. PMID: 15880549.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCellsPHPublic Health
    124. Atmosphere. Air pollution-related illness: effects of particles. Science. 2005 May 06; 308(5723):804-6. Nel A. PMID: 15879201.
      View in: PubMed   Mentions: 240     Fields:    Translation:HumansAnimalsPHPublic Health
    125. Nitrotyrosine-modified proteins and oxidative stress induced by diesel exhaust particles. Electrophoresis. 2005 Jan; 26(1):280-92. Xiao GG, Nel AE, Loo JA. PMID: 15624150.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    126. Quinones and aromatic chemical compounds in particulate matter induce mitochondrial dysfunction: implications for ultrafine particle toxicity. Environ Health Perspect. 2004 Oct; 112(14):1347-58. Xia T, Korge P, Weiss JN, Li N, Venkatesen MI, Sioutas C, Nel A. PMID: 15471724; PMCID: PMC1247559.
      View in: PubMed   Mentions: 98     Fields:    Translation:AnimalsCells
    127. Nrf2 is a key transcription factor that regulates antioxidant defense in macrophages and epithelial cells: protecting against the proinflammatory and oxidizing effects of diesel exhaust chemicals. J Immunol. 2004 Sep 01; 173(5):3467-81. Li N, Alam J, Venkatesan MI, Eiguren-Fernandez A, Schmitz D, Di Stefano E, Slaughter N, Killeen E, Wang X, Huang A, Wang M, Miguel AH, Cho A, Sioutas C, Nel AE. PMID: 15322212.
      View in: PubMed   Mentions: 174     Fields:    Translation:Cells
    128. Proteome analysis of lipid rafts in Jurkat cells characterizes a raft subset that is involved in NF-kappaB activation. J Proteome Res. 2004 May-Jun; 3(3):445-54. Tu X, Huang A, Bae D, Slaughter N, Whitelegge J, Crother T, Bickel PE, Nel A. PMID: 15253425.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    129. Particulate air pollutants and asthma. A paradigm for the role of oxidative stress in PM-induced adverse health effects. Clin Immunol. 2003 Dec; 109(3):250-65. Li N, Hao M, Phalen RF, Hinds WC, Nel AE. PMID: 14697739.
      View in: PubMed   Mentions: 188     Fields:    Translation:Humans
    130. Diesel exhaust particles exert acute effects on airway inflammation and function in murine allergen provocation models. J Allergy Clin Immunol. 2003 Nov; 112(5):905-14. Hao M, Comier S, Wang M, Lee JJ, Nel A. PMID: 14610479.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsPHPublic Health
    131. Use of proteomics to demonstrate a hierarchical oxidative stress response to diesel exhaust particle chemicals in a macrophage cell line. J Biol Chem. 2003 Dec 12; 278(50):50781-90. Xiao GG, Wang M, Li N, Loo JA, Nel AE. PMID: 14522998.
      View in: PubMed   Mentions: 118     Fields:    Translation:AnimalsCells
    132. Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. Environ Health Perspect. 2003 Apr; 111(4):455-60. Li N, Sioutas C, Cho A, Schmitz D, Misra C, Sempf J, Wang M, Oberley T, Froines J, Nel A. PMID: 12676598; PMCID: PMC1241427.
      View in: PubMed   Mentions: 425     Fields:    Translation:HumansAnimalsCells
    133. Comparison of the pro-oxidative and proinflammatory effects of organic diesel exhaust particle chemicals in bronchial epithelial cells and macrophages. J Immunol. 2002 Oct 15; 169(8):4531-41. Li N, Wang M, Oberley TD, Sempf JM, Nel AE. PMID: 12370390.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansCells
    134. CD40-mediated p38 mitogen-activated protein kinase activation is required for immunoglobulin class switch recombination to IgE. J Allergy Clin Immunol. 2002 Sep; 110(3):421-8. Zhang K, Zhang L, Zhu D, Bae D, Nel A, Saxon A. PMID: 12209089.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    135. T-cell activation through the antigen receptor. Part 2: role of signaling cascades in T-cell differentiation, anergy, immune senescence, and development of immunotherapy. J Allergy Clin Immunol. 2002 Jun; 109(6):901-15. Nel AE, Slaughter N. PMID: 12063516.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    136. T-cell activation through the antigen receptor. Part 1: signaling components, signaling pathways, and signal integration at the T-cell antigen receptor synapse. J Allergy Clin Immunol. 2002 May; 109(5):758-70. Nel AE. PMID: 11994696.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansCells
    137. Use of a stratified oxidative stress model to study the biological effects of ambient concentrated and diesel exhaust particulate matter. Inhal Toxicol. 2002 May; 14(5):459-86. Li N, Kim S, Wang M, Froines J, Sioutas C, Nel A. PMID: 12028803.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    138. Protein kinase D is a downstream target of protein kinase Ctheta. Biochem Biophys Res Commun. 2002 Mar 01; 291(3):444-52. Yuan J, Bae D, Cantrell D, Nel AE, Rozengurt E. PMID: 11855809.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    139. Thiol antioxidants inhibit the adjuvant effects of aerosolized diesel exhaust particles in a murine model for ovalbumin sensitization. J Immunol. 2002 Mar 01; 168(5):2560-7. Whitekus MJ, Li N, Zhang M, Wang M, Horwitz MA, Nelson SK, Horwitz LD, Brechun N, Diaz-Sanchez D, Nel AE. PMID: 11859152.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
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