Patrick Allard

Title(s)Professor, Institute for Society And Genetics
SchoolCollege of Letters and Science
ORCID ORCID Icon0000-0001-7765-1547 Additional info
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    Collapse Biography 
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    McGill University, CanadaPh.D.09/2005Biology
    Harvard Medical School, USAPostdoctoral Fellowship10/2012Genetics

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    E-Cigarette Vaping during Pregnancy and Lactation, Germ Cell Epigenetic Memory, and Transgenerational Asthma
    NIH R01HL151769Jun 1, 2020 - May 31, 2024
    Role: Co-Principal Investigator
    Mechanisms of environmental epigenetic disruption and memory of exposure in germ cells
    NIH R01ES027487Mar 1, 2017 - Feb 28, 2022
    Role: Principal Investigator
    Germ Cell-Mediated Epigenetic Memory of Ethanol Exposure
    NIH R21AA024889Jan 16, 2017 - Dec 31, 2019
    Role: Principal Investigator
    Student-to-Scientist Bridge Program in Environmental Health Science (S2S Bridge)
    NIH R25ES025507Apr 2, 2015 - Mar 31, 2021
    Role: Co-Principal Investigator
    Design of a high-throughput screen for chemicals that cause meiotic aneuploidy
    NIH R00ES020353Dec 1, 2012 - Nov 30, 2016
    Role: Principal Investigator
    Design of a high-throughput screen for chemicals that cause meiotic aneuploidy
    NIH K99ES020353Sep 1, 2011 - Nov 30, 2012
    Role: Principal Investigator
    Training in Molecular Toxicology
    NIH T32ES015457Jul 1, 2007 - Jun 30, 2026
    Role: Co-Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Rapid identification of reproductive toxicants among environmental chemicals using an in vivo evaluation of gametogenesis in budding yeast Saccharomyces cerevisiae. Reprod Toxicol. 2024 Sep; 128:108630. Kumar R, Oke A, Rockmill B, de Cruz M, Verduzco R, Shodhan A, Woodruff-Madeira X, Abrahamsson DP, Varshavsky J, Lam J, Robinson JF, Allard P, Woodruff TJ, Fung JC. PMID: 38906490.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    2. Analyzing high-throughput assay data to advance the rapid screening of environmental chemicals for human reproductive toxicity. bioRxiv. 2024 May 22. Varshavsky JR, Lam J, Cooper C, Allard P, Fung J, Oke A, Kumar R, Robinson JF, Woodruff TJ. PMID: 38826231; PMCID: PMC11142090.
      View in: PubMed   Mentions:
    3. Screening and characterization of 133 physiologically-relevant environmental chemicals for reproductive toxicity. Reprod Toxicol. 2024 Jun; 126:108602. Ulaganathan G, Jiang H, Canio N, Oke A, Armstrong SS, Abrahamsson D, Varshavsky JR, Lam J, Cooper C, Robinson JF, Fung JC, Woodruff TJ, Allard P. PMID: 38723698; PMCID: PMC11155672.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    4. Screening and characterization of 133 physiologically-relevant environmental chemicals for reproductive toxicity. bioRxiv. 2024 Mar 27. Ulaganathan G, Jiang H, Canio N, Oke A, Armstrong SS, Abrahamsson D, Varshavsky JR, Lam J, Cooper C, Robinson JF, Fung JC, Woodruff TJ, Allard P. PMID: 38585844; PMCID: PMC10996516.
      View in: PubMed   Mentions:
    5. Inter- and trans-generational impacts of environmental exposures on the germline resolved at the single-cell level. Curr Opin Toxicol. 2024 Jun; 38. Hatai D, Levenson MT, Rehan VK, Allard P. PMID: 38586548; PMCID: PMC10993723.
      View in: PubMed   Mentions:
    6. Metabolic memory of Δ9-tetrahydrocannabinol exposure in pluripotent stem cells and primordial germ cells-like cells. Elife. 2023 Dec 27; 12. Verdikt R, Armstrong AA, Cheng J, Hwang YS, Clark AT, Yang X, Allard P. PMID: 38150302; PMCID: PMC10752584.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    7. Protocol for nuclear dissociation of the adult C. elegans for single-nucleus RNA sequencing and its application for mapping environmental responses. STAR Protoc. 2023 Dec 15; 4(4):102756. Levenson MT, Barrere-Cain R, Truong L, Chen YW, Shuck K, Panter B, Reich E, Yang X, Allard P. PMID: 38043054; PMCID: PMC10730361.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    8. Metabolic memory of Δ9-tetrahydrocannabinol exposure in pluripotent stem cells and primordial germ cells-like cells. bioRxiv. 2023 Oct 02. Verdikt R, Armstrong AA, Cheng J, Hwang YS, Clark AT, Yang X, Allard P. PMID: 36993751; PMCID: PMC10054962.
      View in: PubMed   Mentions:
    9. Single-nucleus resolution mapping of the adult C. elegans and its application to elucidate inter- and trans-generational response to alcohol. Cell Rep. 2023 06 27; 42(6):112535. Truong L, Chen YW, Barrere-Cain R, Levenson MT, Shuck K, Xiao W, da Veiga Beltrame E, Panter B, Reich E, Sternberg PW, Yang X, Allard P. PMID: 37227821; PMCID: PMC10592506.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    10. Transgenerational inheritance and its modulation by environmental cues. Curr Top Dev Biol. 2023; 152:31-76. Verdikt R, Armstrong AA, Allard P. PMID: 36707214; PMCID: PMC9940302.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    11. Toxicoepigenetics for Risk Assessment: Bridging the Gap Between Basic and Regulatory Science. Epigenet Insights. 2022; 15:25168657221113149. Le Goff A, Louvel S, Boullier H, Allard P. PMID: 35860623; PMCID: PMC9290111.
      View in: PubMed   Mentions: 2  
    12. Examining the Developmental Trajectory of an in Vitro Model of Mouse Primordial Germ Cells following Exposure to Environmentally Relevant Bisphenol A Levels. Environ Health Perspect. 2021 09; 129(9):97013. Ooi SKT, Jiang H, Kang Y, Allard P. PMID: 34585602; PMCID: PMC8480152.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    13. Metabolo-epigenetics: the interplay of metabolism and epigenetics during early germ cells development Biol Reprod. 2021 09 14; 105(3):616-624. Verdikt R, Allard P. PMID: 34132770; PMCID: PMC8444669.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    14. Strength of Cu-efflux response in Escherichia coli coordinates metal resistance in Caenorhabditis elegans and contributes to the severity of environmental toxicity. J Biol Chem. 2021 09; 297(3):101060. Shafer CM, Tseng A, Allard P, McEvoy MM. PMID: 34375643; PMCID: PMC8424214.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    15. Challenging dogmas: How transgenerational epigenetics reshapes our views on life. J Exp Zool A Ecol Integr Physiol. 2022 01; 337(1):70-74. Wang HD, Allard P. PMID: 33900057; PMCID: PMC8546026.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    16. Heritable changeability: Epimutation and the legacy of negative definition in epigenetic concepts. Stud Hist Philos Sci. 2021 04; 86:35-46. Le Goff A, Allard P, Landecker H. PMID: 33965662.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    17. What Is Lost in the Weismann Barrier? J Dev Biol. 2020 Dec 16; 8(4). Bline AP, Le Goff A, Allard P. PMID: 33339122; PMCID: PMC7768413.
      View in: PubMed   Mentions: 7  
    18. An Understudied Dimension: Why Age Needs to Be Considered When Studying Epigenetic-Environment Interactions. Epigenet Insights. 2020; 13:2516865720947014. Barrere-Cain R, Allard P. PMID: 32864568; PMCID: PMC7430070.
      View in: PubMed   Mentions: 8  
    19. Perinatal nicotine exposure-induced transgenerational asthma: Effects of reexposure in F1 gestation. FASEB J. 2020 09; 34(9):11444-11459. Liu J, Yu C, Doherty TM, Akbari O, Allard P, Rehan VK. PMID: 32654256; PMCID: PMC7839813.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCellsPHPublic Health
    20. Different temporal trends of exposure to Bisphenol A among international travelers between Los Angeles and Beijing. Environ Int. 2020 08; 141:105758. Lin Y, Qiu X, Liu J, Tseng CH, Allard P, Araujo JA, Zhu Y. PMID: 32402980; PMCID: PMC7283011.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    21. Epigenetics in the public sphere: interdisciplinary perspectives. Environ Epigenet. 2019 Oct; 5(4):dvz019. Dubois M, Louvel S, Le Goff A, Guaspare C, Allard P. PMID: 31660206; PMCID: PMC6812041.
      View in: PubMed   Mentions: 7  
    22. Diagnostic utility of transcriptome sequencing for rare Mendelian diseases. Genet Med. 2020 03; 22(3):490-499. Lee H, Huang AY, Wang LK, Yoon AJ, Renteria G, Eskin A, Signer RH, Dorrani N, Nieves-Rodriguez S, Wan J, Douine ED, Woods JD, Dell'Angelica EC, Fogel BL, Martin MG, Butte MJ, Parker NH, Wang RT, Shieh PB, Wong DA, Gallant N, Singh KE, Tavyev Asher YJ, Sinsheimer JS, Krakow D, Loo SK, Allard P, Papp JC, Undiagnosed Diseases Network, Palmer CGS, Martinez-Agosto JA, Nelson SF. PMID: 31607746; PMCID: PMC7405636.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansCells
    23. BPA interferes with StAR-mediated mitochondrial cholesterol transport to induce germline dysfunctions. Reprod Toxicol. 2019 12; 90:24-32. Chen Y, Panter B, Hussain A, Gibbs K, Ferreira D, Allard P. PMID: 31445225; PMCID: PMC6885526.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    24. Reported environmental exposures are inversely associated with obtaining a genetic diagnosis in the Undiagnosed Diseases Network. Am J Med Genet A. 2019 06; 179(6):958-965. Silverman EK, Allard P, Loscalzo J, Mulvihill JJ, Korrick SA, Undiagnosed Diseases Network. PMID: 30903737.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    25. A Vault-Encapsulated Enzyme Approach for Efficient Degradation and Detoxification of Bisphenol A and Its Analogues. ACS Sustain Chem Eng. 2019 Mar 18; 7(6):5808-5817. Wang M, Chen Y, Kickhoefer VA, Rome LH, Allard P, Mahendra S. PMID: 36419408; PMCID: PMC9681160.
      View in: PubMed   Mentions: 2  
    26. Prenatal Bisphenol A Exposure in Mice Induces Multitissue Multiomics Disruptions Linking to Cardiometabolic Disorders. Endocrinology. 2019 02 01; 160(2):409-429. Shu L, Meng Q, Diamante G, Tsai B, Chen YW, Mikhail A, Luk H, Ritz B, Allard P, Yang X. PMID: 30566610; PMCID: PMC6349005.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    27. Histone Modifications: Epigenetic Mediators of Environmental Exposure Memory. Epigenet Insights. 2018; 11:2516865718803641. Camacho J, Allard P. PMID: 30443644; PMCID: PMC6233965.
      View in: PubMed   Mentions: 3  
    28. Caenorhabditis elegans as an emerging model system in environmental epigenetics. Environ Mol Mutagen. 2018 08; 59(7):560-575. Weinhouse C, Truong L, Meyer JN, Allard P. PMID: 30091255; PMCID: PMC6113102.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    29. The Memory of Environmental Chemical Exposure in C. elegans Is Dependent on the Jumonji Demethylases jmjd-2 and jmjd-3/utx-1. Cell Rep. 2018 05 22; 23(8):2392-2404. Camacho J, Truong L, Kurt Z, Chen YW, Morselli M, Gutierrez G, Pellegrini M, Yang X, Allard P. PMID: 29791850; PMCID: PMC6003705.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    30. Epigenetic Applications in Adverse Outcome Pathways and Environmental Risk Evaluation. Environ Health Perspect. 2018 04 12; 126(4):045001. Angrish MM, Allard P, McCullough SD, Druwe IL, Helbling Chadwick L, Hines E, Chorley BN. PMID: 29669403; PMCID: PMC6071815.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansPHPublic Health
    31. Comparative global immune-related gene profiling of somatic cells, human pluripotent stem cells and their derivatives: implication for human lymphocyte proliferation. Exp Mol Med. 2017 09 15; 49(9):e376. Wu CE, Yu CW, Chang KW, Chou WH, Lu CY, Ghelfi E, Wu FC, Jan PS, Huang MC, Allard P, Lin SP, Ho HN, Chen HF. PMID: 28912571; PMCID: PMC5628273.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    32. Has Toxicity Testing Moved into the 21st Century? A Survey and Analysis of Perceptions in the Field of Toxicology. Environ Health Perspect. 2017 08 30; 125(8):087024. Zaunbrecher V, Beryt E, Parodi D, Telesca D, Doherty J, Malloy T, Allard P. PMID: 28934728; PMCID: PMC5783667.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    33. Advancing alternatives analysis: The role of predictive toxicology in selecting safer chemical products and processes. Integr Environ Assess Manag. 2017 Sep; 13(5):915-925. Malloy T, Zaunbrecher V, Beryt E, Judson R, Tice R, Allard P, Blake A, Cote I, Godwin H, Heine L, Kerzic P, Kostal J, Marchant G, McPartland J, Moran K, Nel A, Ogunseitan O, Rossi M, Thayer K, Tickner J, Whittaker M, Zarker K. PMID: 28247928.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    34. Exposure to the BPA-Substitute Bisphenol S Causes Unique Alterations of Germline Function. PLoS Genet. 2016 07; 12(7):e1006223. Chen Y, Shu L, Qiu Z, Lee DY, Settle SJ, Que Hee S, Telesca D, Yang X, Allard P. PMID: 27472198; PMCID: PMC4966967.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    35. Fast Functional Germline and Epigenetic Assays in the Nematode Caenorhabditis elegans. Methods Mol Biol. 2016; 1473:99-107. Lundby Z, Camacho J, Allard P. PMID: 27518628.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    36. Emerging Toxicity Models from Emerging Scientists. Toxicol Res (Camb). 2015 May 01; 4(3):545-547. Allard P. PMID: 25987979; PMCID: PMC4433035.
      View in: PubMed   Mentions: 1  
    37. Reproductive toxicity and meiotic dysfunction following exposure to the pesticides Maneb, Diazinon and Fenarimol. Toxicol Res (Camb). 2015 May; 4(3):645-654. Parodi DA, Sjarif J, Chen Y, Allard P. PMID: 25984295; PMCID: PMC4433152.
      View in: PubMed   Mentions: 5  
    38. Models of germ cell development and their application for toxicity studies. Environ Mol Mutagen. 2015 Oct; 56(8):637-49. Ferreira DW, Allard P. PMID: 25821157; PMCID: PMC4586303.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    39. Comprehensive assessment of germline chemical toxicity using the nematode Caenorhabditis elegans. J Vis Exp. 2015 Feb 22; (96). Parodi DA, Damoiseaux R, Allard P. PMID: 25741987; PMCID: PMC4354655.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    40. Using sparse dose-response data for wildlife risk assessment. Integr Environ Assess Manag. 2014 Jan; 10(1):3-11. Hill RA, Pyper BJ, Lawrence GS, Mann GS, Allard P, Mackintosh CE, Healey N, Dwyer J, Trowell J. PMID: 23913468.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    41. A C. elegans screening platform for the rapid assessment of chemical disruption of germline function. Environ Health Perspect. 2013 Jun; 121(6):717-24. Allard P, Kleinstreuer NC, Knudsen TB, Colaiácovo MP. PMID: 23603051; PMCID: PMC3672921.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    42. Mechanistic insights into the action of Bisphenol A on the germline using C. elegans. Cell Cycle. 2011 Jan 15; 10(2):183-4. Allard P, Colaiácovo MP. PMID: 21228622.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    43. Bisphenol A impairs the double-strand break repair machinery in the germline and causes chromosome abnormalities. Proc Natl Acad Sci U S A. 2010 Nov 23; 107(47):20405-10. Allard P, Colaiácovo MP. PMID: 21059909; PMCID: PMC2996676.
      View in: PubMed   Mentions: 71     Fields:    Translation:AnimalsCells
    44. Recommendations for the development and application of wildlife toxicity reference values. Integr Environ Assess Manag. 2010 Jan; 6(1):28-37. Allard P, Fairbrother A, Hope BK, Hull RN, Johnson MS, Kapustka L, Mann G, McDonald B, Sample BE. PMID: 19558201.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsPHPublic Health
    45. Proteasomal activity is required to initiate and to sustain translational activation of messenger RNA encoding the stem-loop-binding protein during meiotic maturation in mice. Biol Reprod. 2010 Jan; 82(1):123-31. Yang Q, Allard P, Huang M, Zhang W, Clarke HJ. PMID: 19759367; PMCID: PMC2844492.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
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