Tian Xia

Title(s)	Adjunct Professor, Medicine
School	Medicine
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Research

Research Activities and Funding

Toxicological Profiling of Engineered Nanomaterials (ENMs) in the MPS (RES)
NIH U01ES027237Sep 1, 2016 - Aug 31, 2021
Role: Co-Principal Investigator

Carbon Nanotube Structure-Activity Relationships for Predictive Toxicology
NIH R01ES022698Dec 9, 2013 - Oct 31, 2019
Role: Co-Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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Differential Toxicity of Electronic Cigarette Aerosols Generated from Different Generations of Devices In Vitro and In Vivo. Environ Health (Wash). 2023 Nov 17; 1(5):315-323. Ma T, Chen H, Liao YP, Li J, Wang X, Li L, Li J, Zhu Y, Xia T. PMID: 38028320; PMCID: PMC10660664.

View in: PubMed Mentions:
Recent Advances in Site-Specific Lipid Nanoparticles for mRNA Delivery. ACS Nanosci Au. 2023 Jun 21; 3(3):192-203. Xu X, Xia T. PMID: 37360845; PMCID: PMC10288611.

View in: PubMed Mentions: 3
The dependence of particle size on cell toxicity for modern mining dust. Sci Rep. 2023 03 29; 13(1):5101. Chen YH, Nguyen D, Brindley S, Ma T, Xia T, Brune J, Brown JM, Tsai CS. PMID: 36991007; PMCID: PMC10060429.

View in: PubMed Mentions: Fields:
Sci Science
Translation:Humans
Use of a Liver-Targeting Immune-Tolerogenic mRNA Lipid Nanoparticle Platform to Treat Peanut-Induced Anaphylaxis by Single- and Multiple-Epitope Nucleotide Sequence Delivery. ACS Nano. 2023 03 14; 17(5):4942-4957. Xu X, Wang X, Liao YP, Luo L, Xia T, Nel AE. PMID: 36853930; PMCID: PMC10019335.

View in: PubMed Mentions: 10 Fields:
Nan Nanotechnology
Translation:Animals Cells
Determination of the nanoparticle- and cell-specific toxicological mechanisms in 3D liver spheroids using scRNAseq analysis. Nano Today. 2022 Dec; 47. Li J, Diamante G, Ahn IS, Wijaya D, Wang X, Chang CH, Ha SM, Immadisetty K, Meng H, Nel A, Yang X, Xia T. PMID: 36911538; PMCID: PMC10004129.

View in: PubMed Mentions:
CeO2 nanoparticles induce pulmonary fibrosis via activating S1P pathway as revealed by metabolomics. Nano Today. 2022 Aug; 45. Cui L, Wang X, Zhao X, Sun B, Xia T, Hu S. PMID: 36910843; PMCID: PMC9997866.

View in: PubMed Mentions: 2
Use of a Liver-targeting Nanoparticle Platform to Intervene in Peanut-induced anaphylaxis through delivery of an Ara h2 T-cell Epitope. Nano Today. 2022 Feb; 42. Liu Q, Wang X, Liao YP, Chang CH, Li J, Xia T, Nel AE. PMID: 36969911; PMCID: PMC10038170.

View in: PubMed Mentions: 5
Nanocellulose Length Determines the Differential Cytotoxic Effects and Inflammatory Responses in Macrophages and Hepatocytes. Small. 2021 09; 17(38):e2102545. Li J, Wang X, Chang CH, Jiang J, Liu Q, Liu X, Liao YP, Ma T, Meng H, Xia T. PMID: 34363305; PMCID: PMC8460616.

View in: PubMed Mentions: 12 Fields:
Bio Biomedical Engineering Nan Nanotechnology
Translation:Cells
Dissolution of 2D Molybdenum Disulfide Generates Differential Toxicity among Liver Cell Types Compared to Non-Toxic 2D Boron Nitride Effects. Small. 2021 06; 17(25):e2101084. Li J, Guiney LM, Downing JR, Wang X, Chang CH, Jiang J, Liu Q, Liu X, Mei KC, Liao YP, Ma T, Meng H, Hersam MC, Nel AE, Xia T. PMID: 34032006; PMCID: PMC8225588.

View in: PubMed Mentions: 8 Fields:
Bio Biomedical Engineering Nan Nanotechnology
Translation:Cells
Arsenic, Cadmium, Lead, and Mercury in Lactation Foods and Prenatal Vitamins: Potentially Avoidable Exposure for Breastfeeding Mothers and Infants. Breastfeed Med. 2021 07; 16(7):558-563. Canale S, Blute N, Xia T, Thomas M, Gee M, Chang CH. PMID: 33567220.

View in: PubMed Mentions: 1 Fields:
Nut Nutritional Sciences
Translation:Humans
Nanoparticle-Based Activatable Probes for Bioimaging. Adv Biol (Weinh). 2021 01; 5(1):e2000193. Ma T, Xia T. PMID: 33724732; PMCID: PMC7966733.

View in: PubMed Mentions: Fields:
Bio Biomedical Engineering Bio Biotechnology
Translation:Cells
Lateral size of graphene oxide determines differential cellular uptake and cell death pathways in Kupffer cells, LSECs, and hepatocytes. Nano Today. 2021 Apr; 37. Li J, Wang X, Mei KC, Chang CH, Jiang J, Liu X, Liu Q, Guiney LM, Hersam MC, Liao YP, Meng H, Xia T. PMID: 34055032; PMCID: PMC8153408.

View in: PubMed Mentions: 21
Antigen- and Epitope-Delivering Nanoparticles Targeting Liver Induce Comparable Immunotolerance in Allergic Airway Disease and Anaphylaxis as Nanoparticle-Delivering Pharmaceuticals. ACS Nano. 2021 01 26; 15(1):1608-1626. Liu Q, Wang X, Liu X, Liao YP, Chang CH, Mei KC, Jiang J, Tseng S, Gochman G, Huang M, Thatcher Z, Li J, Allen SD, Lucido L, Xia T, Nel AE. PMID: 33351586; PMCID: PMC7943028.

View in: PubMed Mentions: 18 Fields:
Nan Nanotechnology
Translation:Animals Cells
Electronic cigarette aerosols induce oxidative stress-dependent cell death and NF-κB mediated acute lung inflammation in mice. Arch Toxicol. 2021 01; 95(1):195-205. Ma T, Wang X, Li L, Sun B, Zhu Y, Xia T. PMID: 33159582; PMCID: PMC7855759.

View in: PubMed Mentions: 11 Fields:
Tox Toxicology
Translation:Humans Animals Cells PHPublic Health
Liposomal Delivery of Mitoxantrone and a Cholesteryl Indoximod Prodrug Provides Effective Chemo-immunotherapy in Multiple Solid Tumors. ACS Nano. 2020 10 27; 14(10):13343-13366. Mei KC, Liao YP, Jiang J, Chiang M, Khazaieli M, Liu X, Wang X, Liu Q, Chang CH, Zhang X, Li J, Ji Y, Melano B, Telesca D, Xia T, Meng H, Nel AE. PMID: 32940463; PMCID: PMC8023019.

View in: PubMed Mentions: 26 Fields:
Nan Nanotechnology
Translation:Animals Cells
Mechanistic Differences in Cell Death Responses to Metal-Based Engineered Nanomaterials in Kupffer Cells and Hepatocytes. Small. 2020 05; 16(21):e2000528. Wang X, Chang CH, Jiang J, Liu X, Li J, Liu Q, Liao YP, Li L, Nel AE, Xia T. PMID: 32337854; PMCID: PMC7263057.

View in: PubMed Mentions: 20 Fields:
Bio Biomedical Engineering Nan Nanotechnology
Translation:Animals Cells
Effects of Electronic Cigarettes on Indoor Air Quality and Health. Annu Rev Public Health. 2020 04 02; 41:363-380. Li L, Lin Y, Xia T, Zhu Y. PMID: 31910714; PMCID: PMC7346849.

View in: PubMed Mentions: 22 Fields:
Pub Public Health
Translation:Humans PHPublic Health
E-cigarette aerosols induce unfolded protein response in normal human oral keratinocytes. J Cancer. 2019; 10(27):6915-6924. Ji EH, Elzakra N, Chen W, Cui L, Lee ES, Sun B, Messadi D, Xia T, Zhu Y, Hu S. PMID: 31839827; PMCID: PMC6909953.

View in: PubMed Mentions: 4
Predictive Metabolomic Signatures for Safety Assessment of Metal Oxide Nanoparticles. ACS Nano. 2019 11 26; 13(11):13065-13082. Cui L, Wang X, Sun B, Xia T, Hu S. PMID: 31682760.

View in: PubMed Mentions: 13 Fields:
Nan Nanotechnology
Translation:Humans Cells
The Crystallinity and Aspect Ratio of Cellulose Nanomaterials Determine Their Pro-Inflammatory and Immune Adjuvant Effects In Vitro and In Vivo. Small. 2019 10; 15(42):e1901642. Wang X, Chang CH, Jiang J, Liu Q, Liao YP, Lu J, Li L, Liu X, Kim J, Ahmed A, Nel AE, Xia T. PMID: 31461215; PMCID: PMC6800804.

View in: PubMed Mentions: 17 Fields:
Bio Biomedical Engineering Nan Nanotechnology
Translation:Humans Animals Cells
Engineering Protective Polymer Coatings for Liver Microtissues. Chem Res Toxicol. 2019 01 22; 32(1):49-56. Chen X, Jiang W, Ahmed A, Mahon CS, Müllner M, Cao B, Xia T. PMID: 30499291.

View in: PubMed Mentions: 1 Fields:
Tox Toxicology
Translation:Animals Cells
Current approaches for safer design of engineered nanomaterials. Ecotoxicol Environ Saf. 2018 Dec 30; 166:294-300. Hwang R, Mirshafiee V, Zhu Y, Xia T. PMID: 30273853; PMCID: PMC6192839.

View in: PubMed Mentions: 7 Fields:
Env Environmental Health Tox Toxicology
Translation:Humans PHPublic Health
Creative use of analytical techniques and high-throughput technology to facilitate safety assessment of engineered nanomaterials. Anal Bioanal Chem. 2018 Sep; 410(24):6097-6111. Liu Q, Wang X, Xia T. PMID: 30066194; PMCID: PMC6119091.

View in: PubMed Mentions: 3 Fields:
Che Chemistry Techniques
Translation:Humans Animals
Toxicological Profiling of Highly Purified Single-Walled Carbon Nanotubes with Different Lengths in the Rodent Lung and Escherichia Coli. Small. 2018 06; 14(23):e1703915. Wang X, Lee JH, Li R, Liao YP, Kang J, Chang CH, Guiney LM, Mirshafiee V, Li L, Lu J, Xia T, Hersam MC, Nel AE. PMID: 29733549; PMCID: PMC6239219.

View in: PubMed Mentions: 7 Fields:
Bio Biomedical Engineering Nan Nanotechnology
Translation:Humans Animals Cells
Toxicological Profiling of Metal Oxide Nanoparticles in Liver Context Reveals Pyroptosis in Kupffer Cells and Macrophages versus Apoptosis in Hepatocytes. ACS Nano. 2018 04 24; 12(4):3836-3852. Mirshafiee V, Sun B, Chang CH, Liao YP, Jiang W, Jiang J, Liu X, Wang X, Xia T, Nel AE. PMID: 29543433; PMCID: PMC5946698.

View in: PubMed Mentions: 49 Fields:
Nan Nanotechnology
Translation:Humans Animals Cells
Upconversion nanoparticle mediated optogenetics for targeted deep brain stimulation. Sci Bull (Beijing). 2018 Apr 15; 63(7):405-407. Xia T. PMID: 36658933.

View in: PubMed Mentions: 2 Fields:
Sci Science
Critical role of immunogenic cell death in cancer therapy. Sci Bull (Beijing). 2017 Nov 15; 62(21):1427-1429. Xia T. PMID: 36659389.

View in: PubMed Mentions: Fields:
Sci Science
The Genetic Heterogeneity among Different Mouse Strains Impacts the Lung Injury Potential of Multiwalled Carbon Nanotubes. Small. 2017 09; 13(33). Wang X, Liao YP, Telesca D, Chang CH, Xia T, Nel AE. PMID: 28677920; PMCID: PMC5581261.

View in: PubMed Mentions: 6 Fields:
Bio Biomedical Engineering Nan Nanotechnology
Translation:Humans Animals Cells
Multifunctional nanotherapeutics for treatment of ocular disease. Ann Eye Sci. 2017 Apr; 2. Xia T. PMID: 30123872; PMCID: PMC6097193.

View in: PubMed Mentions:
Facilitating Translational Nanomedicine via Predictive Safety Assessment. Mol Ther. 2017 07 05; 25(7):1522-1530. Mirshafiee V, Jiang W, Sun B, Wang X, Xia T. PMID: 28412168; PMCID: PMC5498808.

View in: PubMed Mentions: 12 Fields:
Mol Molecular Biology The Therapeutics
Translation:Humans
Pro-Inflammatory and Pro-Fibrogenic Effects of Ionic and Particulate Arsenide and Indium-Containing Semiconductor Materials in the Murine Lung. ACS Nano. 2017 02 28; 11(2):1869-1883. Jiang W, Wang X, Osborne OJ, Du Y, Chang CH, Liao YP, Sun B, Jiang J, Ji Z, Li R, Liu X, Lu J, Lin S, Meng H, Xia T, Nel AE. PMID: 28177603; PMCID: PMC5543990.

View in: PubMed Mentions: 1 Fields:
Nan Nanotechnology
Translation:Humans Animals Cells
Structure Activity Relationships of Engineered Nanomaterials in inducing NLRP3 Inflammasome Activation and Chronic Lung Fibrosis. NanoImpact. 2017 Apr; 6:99-108. Wang X, Sun B, Liu S, Xia T. PMID: 28480337; PMCID: PMC5415341.

View in: PubMed Mentions: 19 Fields:
Nan Nanotechnology Tox Toxicology
Nanomaterial-Based Vaccine Adjuvants. J Mater Chem B. 2016 Sep 07; 4(33):5496-5509. Sun B, Xia T. PMID: 30774955; PMCID: PMC6377210.

View in: PubMed Mentions: 34 Fields:
Bio Biochemistry Bio Biotechnology Nan Nanotechnology
Characterization of Electronic Cigarette Aerosol and Its Induction of Oxidative Stress Response in Oral Keratinocytes. PLoS One. 2016; 11(5):e0154447. Ji EH, Sun B, Zhao T, Shu S, Chang CH, Messadi D, Xia T, Zhu Y, Hu S. PMID: 27223106; PMCID: PMC4880184.

View in: PubMed Mentions: 32 Fields:
Med Medicine (General)Sci Science
Translation:Humans Cells
Implications of the Differential Toxicological Effects of III-V Ionic and Particulate Materials for Hazard Assessment of Semiconductor Slurries. ACS Nano. 2015 Dec 22; 9(12):12011-25. Jiang W, Lin S, Chang CH, Ji Z, Sun B, Wang X, Li R, Pon N, Xia T, Nel AE. PMID: 26549624.

View in: PubMed Mentions: 2 Fields:
Nan Nanotechnology
Translation:Humans Cells
Organ-Specific and Size-Dependent Ag Nanoparticle Toxicity in Gills and Intestines of Adult Zebrafish. ACS Nano. 2015 Oct 27; 9(10):9573-84. Osborne OJ, Lin S, Chang CH, Ji Z, Yu X, Wang X, Lin S, Xia T, Nel AE. PMID: 26327297.

View in: PubMed Mentions: 21 Fields:
Nan Nanotechnology
Translation:Animals
Evaluation of Toxicity Ranking for Metal Oxide Nanoparticles via an in Vitro Dosimetry Model. ACS Nano. 2015 Sep 22; 9(9):9303-13. Liu R, Liu HH, Ji Z, Chang CH, Xia T, Nel AE, Cohen Y. PMID: 26284985.

View in: PubMed Mentions: 24 Fields:
Nan Nanotechnology
Differences in the Toxicological Potential of 2D versus Aggregated Molybdenum Disulfide in the Lung. Small. 2015 Oct; 11(38):5079-87. Wang X, Mansukhani ND, Guiney LM, Ji Z, Chang CH, Wang M, Liao YP, Song TB, Sun B, Li R, Xia T, Hersam MC, Nel AE. PMID: 26237579; PMCID: PMC4600460.

View in: PubMed Mentions: 20 Fields:
Bio Biomedical Engineering Nan Nanotechnology
Translation:Humans Animals Cells
New insights into disruption of iron homeostasis by environmental pollutants. J Environ Sci (China). 2015 Aug 01; 34:256-8. Wang X, Xia T. PMID: 26257368.

View in: PubMed Mentions: 2 Fields:
Env Environmental Health
Translation:Humans Animals
Mechanisms of nanosilver-induced toxicological effects: more attention should be paid to its sublethal effects. Nanoscale. 2015 May 07; 7(17):7470-81. Wang Z, Xia T, Liu S. PMID: 25865054; PMCID: PMC4418973.

View in: PubMed Mentions: 20 Fields:
Nan Nanotechnology
Translation:Humans Animals Cells
Mammalian Cells Exhibit a Range of Sensitivities to Silver Nanoparticles that are Partially Explicable by Variations in Antioxidant Defense and Metallothionein Expression. Small. 2015 Aug; 11(31):3797-805. Zhang H, Wang X, Wang M, Li L, Chang CH, Ji Z, Xia T, Nel AE. PMID: 25930061; PMCID: PMC4537384.

View in: PubMed Mentions: 15 Fields:
Bio Biomedical Engineering Nan Nanotechnology
Translation:Humans Animals Cells
Enhancing the imaging and biosafety of upconversion nanoparticles through phosphonate coating. ACS Nano. 2015 Mar 24; 9(3):3293-306. Li R, Ji Z, Dong J, Chang CH, Wang X, Sun B, Wang M, Liao YP, Zink JI, Nel AE, Xia T. PMID: 25727446; PMCID: PMC4415359.

View in: PubMed Mentions: 26 Fields:
Nan Nanotechnology
Translation:Humans Animals Cells
NADPH Oxidase-Dependent NLRP3 Inflammasome Activation and its Important Role in Lung Fibrosis by Multiwalled Carbon Nanotubes. Small. 2015 May 06; 11(17):2087-97. Sun B, Wang X, Ji Z, Wang M, Liao YP, Chang CH, Li R, Zhang H, Nel AE, Xia T. PMID: 25581126; PMCID: PMC4420651.

View in: PubMed Mentions: 74 Fields:
Bio Biomedical Engineering Nan Nanotechnology
Translation:Humans Animals Cells
Interference in autophagosome fusion by rare earth nanoparticles disrupts autophagic flux and regulation of an interleukin-1β producing inflammasome. ACS Nano. 2014 Oct 28; 8(10):10280-92. Li R, Ji Z, Qin H, Kang X, Sun B, Wang M, Chang CH, Wang X, Zhang H, Zou H, Nel AE, Xia T. PMID: 25251502; PMCID: PMC4213039.

View in: PubMed Mentions: 51 Fields:
Nan Nanotechnology
Translation:Humans Cells
Aspect ratio plays a role in the hazard potential of CeO2 nanoparticles in mouse lung and zebrafish gastrointestinal tract. ACS Nano. 2014 May 27; 8(5):4450-64. Lin S, Wang X, Ji Z, Chang CH, Dong Y, Meng H, Liao YP, Wang M, Song TB, Kohan S, Xia T, Zink JI, Lin S, Nel AE. PMID: 24720650; PMCID: PMC4059546.

View in: PubMed Mentions: 28 Fields:
Nan Nanotechnology
Translation:Humans Animals Cells
Association rule mining of cellular responses induced by metal and metal oxide nanoparticles. Analyst. 2014 Mar 07; 139(5):943-53. Liu R, France B, George S, Rallo R, Zhang H, Xia T, Nel AE, Bradley K, Cohen Y. PMID: 24260774.

View in: PubMed Mentions: 8 Fields:
Che Chemistry Techniques
Translation:Animals Cells
Surface interactions with compartmentalized cellular phosphates explain rare earth oxide nanoparticle hazard and provide opportunities for safer design. ACS Nano. 2014 Feb 25; 8(2):1771-83. Li R, Ji Z, Chang CH, Dunphy DR, Cai X, Meng H, Zhang H, Sun B, Wang X, Dong J, Lin S, Wang M, Liao YP, Brinker CJ, Nel A, Xia T. PMID: 24417322; PMCID: PMC3988685.

View in: PubMed Mentions: 57 Fields:
Nan Nanotechnology
Translation:Cells
Engineering an effective immune adjuvant by designed control of shape and crystallinity of aluminum oxyhydroxide nanoparticles. ACS Nano. 2013 Dec 23; 7(12):10834-49. Sun B, Ji Z, Liao YP, Wang M, Wang X, Dong J, Chang CH, Li R, Zhang H, Nel AE, Xia T. PMID: 24261790; PMCID: PMC3899397.

View in: PubMed Mentions: 65 Fields:
Nan Nanotechnology
Translation:Humans Animals Cells
Use of coated silver nanoparticles to understand the relationship of particle dissolution and bioavailability to cell and lung toxicological potential. Small. 2014 Jan 29; 10(2):385-98. Wang X, Ji Z, Chang CH, Zhang H, Wang M, Liao YP, Lin S, Meng H, Li R, Sun B, Winkle LV, Pinkerton KE, Zink JI, Xia T, Nel AE. PMID: 24039004; PMCID: PMC4001734.

View in: PubMed Mentions: 97 Fields:
Bio Biomedical Engineering Nan Nanotechnology
Translation:Humans Animals Cells
Development of structure-activity relationship for metal oxide nanoparticles. Nanoscale. 2013 Jun 21; 5(12):5644-53. Liu R, Zhang HY, Ji ZX, Rallo R, Xia T, Chang CH, Nel A, Cohen Y. PMID: 23689214.

View in: PubMed Mentions: 32 Fields:
Nan Nanotechnology
Translation:Humans Animals Cells
Hierarchical Rank Aggregation with Applications to Nanotoxicology. J Agric Biol Environ Stat. 2013 Jun 01; 18(2):159-177. Patel T, Telesca D, Rallo R, George S, Xia T, Nel AE. PMID: 24839387; PMCID: PMC4023486.

View in: PubMed Mentions: 1
Interlaboratory evaluation of in vitro cytotoxicity and inflammatory responses to engineered nanomaterials: the NIEHS Nano GO Consortium. Environ Health Perspect. 2013 Jun; 121(6):683-90. Xia T, Hamilton RF, Bonner JC, Crandall ED, Elder A, Fazlollahi F, Girtsman TA, Kim K, Mitra S, Ntim SA, Orr G, Tagmount M, Taylor AJ, Telesca D, Tolic A, Vulpe CD, Walker AJ, Wang X, Witzmann FA, Wu N, Xie Y, Zink JI, Nel A, Holian A. PMID: 23649538; PMCID: PMC3672931.

View in: PubMed Mentions: 93 Fields:
Env Environmental Health
Translation:Humans Animals Cells
Surface charge and cellular processing of covalently functionalized multiwall carbon nanotubes determine pulmonary toxicity. ACS Nano. 2013 Mar 26; 7(3):2352-68. Li R, Wang X, Ji Z, Sun B, Zhang H, Chang CH, Lin S, Meng H, Liao YP, Wang M, Li Z, Hwang AA, Song TB, Xu R, Yang Y, Zink JI, Nel AE, Xia T. PMID: 23414138; PMCID: PMC4012619.

View in: PubMed Mentions: 108 Fields:
Nan Nanotechnology
Translation:Humans Animals Cells
Codelivery of an optimal drug/siRNA combination using mesoporous silica nanoparticles to overcome drug resistance in breast cancer in vitro and in vivo. ACS Nano. 2013 Feb 26; 7(2):994-1005. Meng H, Mai WX, Zhang H, Xue M, Xia T, Lin S, Wang X, Zhao Y, Ji Z, Zink JI, Nel AE. PMID: 23289892; PMCID: PMC3620006.

View in: PubMed Mentions: 158 Fields:
Nan Nanotechnology
Translation:Humans Animals Cells
Zebrafish high-throughput screening to study the impact of dissolvable metal oxide nanoparticles on the hatching enzyme, ZHE1. Small. 2013 May 27; 9(9-10):1776-85. Lin S, Zhao Y, Ji Z, Ear J, Chang CH, Zhang H, Low-Kam C, Yamada K, Meng H, Wang X, Liu R, Pokhrel S, Mädler L, Damoiseaux R, Xia T, Godwin HA, Lin S, Nel AE. PMID: 23180726; PMCID: PMC4034474.

View in: PubMed Mentions: 26 Fields:
Bio Biomedical Engineering Nan Nanotechnology
Translation:Animals Cells
NLRP3 inflammasome activation induced by engineered nanomaterials. Small. 2013 May 27; 9(9-10):1595-607. Sun B, Wang X, Ji Z, Li R, Xia T. PMID: 23180683; PMCID: PMC4056676.

View in: PubMed Mentions: 68 Fields:
Bio Biomedical Engineering Nan Nanotechnology
Translation:Humans Cells
Implementation of a multidisciplinary approach to solve complex nano EHS problems by the UC Center for the Environmental Implications of Nanotechnology. Small. 2013 May 27; 9(9-10):1428-43. Xia T, Malasarn D, Lin S, Ji Z, Zhang H, Miller RJ, Keller AA, Nisbet RM, Harthorn BH, Godwin HA, Lenihan HS, Liu R, Gardea-Torresdey J, Cohen Y, Mädler L, Holden PA, Zink JI, Nel AE. PMID: 23027589.

View in: PubMed Mentions: 6 Fields:
Bio Biomedical Engineering Nan Nanotechnology
Processing pathway dependence of amorphous silica nanoparticle toxicity: colloidal vs pyrolytic. J Am Chem Soc. 2012 Sep 26; 134(38):15790-804. Zhang H, Dunphy DR, Jiang X, Meng H, Sun B, Tarn D, Xue M, Wang X, Lin S, Ji Z, Li R, Garcia FL, Yang J, Kirk ML, Xia T, Zink JI, Nel A, Brinker CJ. PMID: 22924492; PMCID: PMC3505689.

View in: PubMed Mentions: 117 Fields:
Che Chemistry
Translation:Humans Cells
Designed synthesis of CeO2 nanorods and nanowires for studying toxicological effects of high aspect ratio nanomaterials. ACS Nano. 2012 Jun 26; 6(6):5366-80. Ji Z, Wang X, Zhang H, Lin S, Meng H, Sun B, George S, Xia T, Nel AE, Zink JI. PMID: 22564147; PMCID: PMC3651271.

View in: PubMed Mentions: 73 Fields:
Nan Nanotechnology
Translation:Humans Cells
Nanomaterial toxicity testing in the 21st century: use of a predictive toxicological approach and high-throughput screening. Acc Chem Res. 2013 Mar 19; 46(3):607-21. Nel A, Xia T, Meng H, Wang X, Lin S, Ji Z, Zhang H. PMID: 22676423; PMCID: PMC4034475.

View in: PubMed Mentions: 140 Fields:
Che Chemistry
Translation:Humans Animals Cells
Pluronic F108 coating decreases the lung fibrosis potential of multiwall carbon nanotubes by reducing lysosomal injury. Nano Lett. 2012 Jun 13; 12(6):3050-61. Wang X, Xia T, Duch MC, Ji Z, Zhang H, Li R, Sun B, Lin S, Meng H, Liao YP, Wang M, Song TB, Yang Y, Hersam MC, Nel AE. PMID: 22546002; PMCID: PMC4143198.

View in: PubMed Mentions: 66 Fields:
Nan Nanotechnology
Translation:Animals Cells
Use of metal oxide nanoparticle band gap to develop a predictive paradigm for oxidative stress and acute pulmonary inflammation. ACS Nano. 2012 May 22; 6(5):4349-68. Zhang H, Ji Z, Xia T, Meng H, Low-Kam C, Liu R, Pokhrel S, Lin S, Wang X, Liao YP, Wang M, Li L, Rallo R, Damoiseaux R, Telesca D, Mädler L, Cohen Y, Zink JI, Nel AE. PMID: 22502734; PMCID: PMC4139054.

View in: PubMed Mentions: 204 Fields:
Nan Nanotechnology
Translation:Animals
Surface defects on plate-shaped silver nanoparticles contribute to its hazard potential in a fish gill cell line and zebrafish embryos. ACS Nano. 2012 May 22; 6(5):3745-59. George S, Lin S, Ji Z, Thomas CR, Li L, Mecklenburg M, Meng H, Wang X, Zhang H, Xia T, Hohman JN, Lin S, Zink JI, Weiss PS, Nel AE. PMID: 22482460; PMCID: PMC4139037.

View in: PubMed Mentions: 67 Fields:
Nan Nanotechnology
Translation:Animals Cells
Automated phenotype recognition for zebrafish embryo based in vivo high throughput toxicity screening of engineered nano-materials. PLoS One. 2012; 7(4):e35014. Liu R, Lin S, Rallo R, Zhao Y, Damoiseaux R, Xia T, Lin S, Nel A, Cohen Y. PMID: 22506062; PMCID: PMC3323610.

View in: PubMed Mentions: 18 Fields:
Med Medicine (General)Sci Science
Translation:Animals
Dispersal state of multiwalled carbon nanotubes elicits profibrogenic cellular responses that correlate with fibrogenesis biomarkers and fibrosis in the murine lung. ACS Nano. 2011 Dec 27; 5(12):9772-87. Wang X, Xia T, Ntim SA, Ji Z, Lin S, Meng H, Chung CH, George S, Zhang H, Wang M, Li N, Yang Y, Castranova V, Mitra S, Bonner JC, Nel AE. PMID: 22047207; PMCID: PMC4136431.

View in: PubMed Mentions: 89 Fields:
Nan Nanotechnology
Translation:Animals
Role of Fe doping in tuning the band gap of TiO2 for the photo-oxidation-induced cytotoxicity paradigm. J Am Chem Soc. 2011 Jul 27; 133(29):11270-8. George S, Pokhrel S, Ji Z, Henderson BL, Xia T, Li L, Zink JI, Nel AE, Mädler L. PMID: 21678906; PMCID: PMC3971840.

View in: PubMed Mentions: 46 Fields:
Che Chemistry
Translation:Animals Cells
Aspect ratio determines the quantity of mesoporous silica nanoparticle uptake by a small GTPase-dependent macropinocytosis mechanism. ACS Nano. 2011 Jun 28; 5(6):4434-47. Meng H, Yang S, Li Z, Xia T, Chen J, Ji Z, Zhang H, Wang X, Lin S, Huang C, Zhou ZH, Zink JI, Nel AE. PMID: 21563770; PMCID: PMC3125420.

View in: PubMed Mentions: 81 Fields:
Nan Nanotechnology
Translation:Humans Cells
Use of size and a copolymer design feature to improve the biodistribution and the enhanced permeability and retention effect of doxorubicin-loaded mesoporous silica nanoparticles in a murine xenograft tumor model. ACS Nano. 2011 May 24; 5(5):4131-44. Meng H, Xue M, Xia T, Ji Z, Tarn DY, Zink JI, Nel AE. PMID: 21524062; PMCID: PMC3905975.

View in: PubMed Mentions: 101 Fields:
Nan Nanotechnology
Translation:Animals
Differential expression of syndecan-1 mediates cationic nanoparticle toxicity in undifferentiated versus differentiated normal human bronchial epithelial cells. ACS Nano. 2011 Apr 26; 5(4):2756-2769. Zhang H, Xia T, Meng H, Xue M, George S, Ji Z, Wang X, Liu R, Wang M, France B, Rallo R, Damoiseaux R, Cohen Y, Bradley KA, Zink JI, Nel AE. PMID: 21366263; PMCID: PMC3896548.

View in: PubMed Mentions: 28 Fields:
Nan Nanotechnology
Translation:Humans Cells
Nanomaterials in the environment: from materials to high-throughput screening to organisms. ACS Nano. 2011 Jan 25; 5(1):13-20. Thomas CR, George S, Horst AM, Ji Z, Miller RJ, Peralta-Videa JR, Xia T, Pokhrel S, Mädler L, Gardea-Torresdey JL, Holden PA, Keller AA, Lenihan HS, Nel AE, Zink JI. PMID: 21261306.

View in: PubMed Mentions: 25 Fields:
Nan Nanotechnology
Translation:Humans Animals
Decreased dissolution of ZnO by iron doping yields nanoparticles with reduced toxicity in the rodent lung and zebrafish embryos. ACS Nano. 2011 Feb 22; 5(2):1223-35. Xia T, Zhao Y, Sager T, George S, Pokhrel S, Li N, Schoenfeld D, Meng H, Lin S, Wang X, Wang M, Ji Z, Zink JI, Mädler L, Castranova V, Lin S, Nel AE. PMID: 21250651; PMCID: PMC3900638.

View in: PubMed Mentions: 107 Fields:
Nan Nanotechnology
Translation:Animals Cells
Quantitative techniques for assessing and controlling the dispersion and biological effects of multiwalled carbon nanotubes in mammalian tissue culture cells. ACS Nano. 2010 Dec 28; 4(12):7241-52. Wang X, Xia T, Ntim SA, Ji Z, George S, Meng H, Zhang H, Castranova V, Mitra S, Nel AE. PMID: 21067152; PMCID: PMC3899393.

View in: PubMed Mentions: 63 Fields:
Nan Nanotechnology
Translation:Humans Animals Cells
Dispersion and stability optimization of TiO2 nanoparticles in cell culture media. Environ Sci Technol. 2010 Oct 01; 44(19):7309-14. Ji Z, Jin X, George S, Xia T, Meng H, Wang X, Suarez E, Zhang H, Hoek EM, Godwin H, Nel AE, Zink JI. PMID: 20536146; PMCID: PMC3971839.

View in: PubMed Mentions: 88 Fields:
Env Environmental Health
Translation:Cells
Autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by pH-sensitive nanovalves. J Am Chem Soc. 2010 Sep 15; 132(36):12690-7. Meng H, Xue M, Xia T, Zhao YL, Tamanoi F, Stoddart JF, Zink JI, Nel AE. PMID: 20718462; PMCID: PMC3116646.

View in: PubMed Mentions: 107 Fields:
Che Chemistry
Translation:Humans Animals Cells
Engineered design of mesoporous silica nanoparticles to deliver doxorubicin and P-glycoprotein siRNA to overcome drug resistance in a cancer cell line. ACS Nano. 2010 Aug 24; 4(8):4539-50. Meng H, Liong M, Xia T, Li Z, Ji Z, Zink JI, Nel AE. PMID: 20731437; PMCID: PMC3899722.

View in: PubMed Mentions: 185 Fields:
Nan Nanotechnology
Translation:Humans Cells
Use of a rapid cytotoxicity screening approach to engineer a safer zinc oxide nanoparticle through iron doping. ACS Nano. 2010 Jan 26; 4(1):15-29. George S, Pokhrel S, Xia T, Gilbert B, Ji Z, Schowalter M, Rosenauer A, Damoiseaux R, Bradley KA, Mädler L, Nel AE. PMID: 20043640; PMCID: PMC3900637.

View in: PubMed Mentions: 121 Fields:
Nan Nanotechnology
Translation:Animals Cells
Polyethyleneimine coating enhances the cellular uptake of mesoporous silica nanoparticles and allows safe delivery of siRNA and DNA constructs. ACS Nano. 2009 Oct 27; 3(10):3273-86. Xia T, Kovochich M, Liong M, Meng H, Kabehie S, George S, Zink JI, Nel AE. PMID: 19739605; PMCID: PMC3900639.

View in: PubMed Mentions: 195 Fields:
Nan Nanotechnology
Translation:Humans Animals Cells
Comparative toxicity of C60 aggregates toward mammalian cells: role of tetrahydrofuran (THF) decomposition. Environ Sci Technol. 2009 Aug 15; 43(16):6378-84. Kovochich M, Espinasse B, Auffan M, Hotze EM, Wessel L, Xia T, Nel AE, Wiesner MR. PMID: 19746740; PMCID: PMC3971833.

View in: PubMed Mentions: 13 Fields:
Env Environmental Health
Translation:Animals Cells
A predictive toxicological paradigm for the safety assessment of nanomaterials. ACS Nano. 2009 Jul 28; 3(7):1620-7. Meng H, Xia T, George S, Nel AE. PMID: 21452863.

View in: PubMed Mentions: 76 Fields:
Nan Nanotechnology
Understanding biophysicochemical interactions at the nano-bio interface. Nat Mater. 2009 Jul; 8(7):543-57. Nel AE, Mädler L, Velegol D, Xia T, Hoek EM, Somasundaran P, Klaessig F, Castranova V, Thompson M. PMID: 19525947.

View in: PubMed Mentions: 1426 Fields:
Che Chemistry Sci Science
Potential health impact of nanoparticles. Annu Rev Public Health. 2009; 30:137-50. Xia T, Li N, Nel AE. PMID: 19705557.

View in: PubMed Mentions: 89 Fields:
Pub Public Health
Translation:Humans PHPublic Health
Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties. ACS Nano. 2008 Oct 28; 2(10):2121-34. Xia T, Kovochich M, Liong M, Mädler L, Gilbert B, Shi H, Yeh JI, Zink JI, Nel AE. PMID: 19206459; PMCID: PMC3959800.

View in: PubMed Mentions: 465 Fields:
Nan Nanotechnology
Translation:Animals Cells
Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery. ACS Nano. 2008 May; 2(5):889-96. Liong M, Lu J, Kovochich M, Xia T, Ruehm SG, Nel AE, Tamanoi F, Zink JI. PMID: 19206485; PMCID: PMC2751731.

View in: PubMed Mentions: 320 Fields:
Nan Nanotechnology
Translation:Cells
The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles. Free Radic Biol Med. 2008 May 01; 44(9):1689-99. Li N, Xia T, Nel AE. PMID: 18313407; PMCID: PMC2387181.

View in: PubMed Mentions: 230 Fields:
Bio Biochemistry Med Medicine (General)
Translation:Humans Animals Cells
Cationic polystyrene nanosphere toxicity depends on cell-specific endocytic and mitochondrial injury pathways. ACS Nano. 2008 Jan; 2(1):85-96. Xia T, Kovochich M, Liong M, Zink JI, Nel AE. PMID: 19206551.

View in: PubMed Mentions: 178 Fields:
Nan Nanotechnology
Translation:Humans Animals Cells
Inhibitory effects of nitric oxide on invasion of human cancer cells. Cancer Lett. 2007 Nov 18; 257(2):274-82. Wang F, Zhang R, Xia T, Hsu E, Cai Y, Gu Z, Hankinson O. PMID: 17869411; PMCID: PMC2763642.

View in: PubMed Mentions: 6 Fields:
Neo Neoplasms
Translation:Humans Cells
Mesoporous Silica Nanoparticles for Cancer Therapy: Energy-Dependent Cellular Uptake and Delivery of Paclitaxel to Cancer Cells. Nanobiotechnology. 2007 May 01; 3(2):89-95. Lu J, Liong M, Sherman S, Xia T, Kovochich M, Nel AE, Zink JI, Tamanoi F. PMID: 19936038; PMCID: PMC2779038.

View in: PubMed Mentions: 50
Impairment of mitochondrial function by particulate matter (PM) and their toxic components: implications for PM-induced cardiovascular and lung disease. Front Biosci. 2007 Jan 01; 12:1238-46. Xia T, Kovochich M, Nel AE. PMID: 17127377.

View in: PubMed Mentions: 34 Fields:
Bio Biology
Translation:Humans Cells
Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm. Nano Lett. 2006 Aug; 6(8):1794-807. Xia T, Kovochich M, Brant J, Hotze M, Sempf J, Oberley T, Sioutas C, Yeh JI, Wiesner MR, Nel AE. PMID: 16895376.

View in: PubMed Mentions: 375 Fields:
Nan Nanotechnology
Translation:Animals Cells
Toxic potential of materials at the nanolevel. Science. 2006 Feb 03; 311(5761):622-7. Nel A, Xia T, Mädler L, Li N. PMID: 16456071.

View in: PubMed Mentions: 1626 Fields:
Sci Science
Translation:Humans Animals PHPublic Health
The role of reactive oxygen species and oxidative stress in mediating particulate matter injury. Clin Occup Environ Med. 2006; 5(4):817-36. Xia T, Kovochich M, Nel A. PMID: 17110294.

View in: PubMed Mentions: 33 Fields:
Env Environmental Health Occ Occupational Medicine
Translation:Humans PHPublic Health
Quinones and aromatic chemical compounds in particulate matter induce mitochondrial dysfunction: implications for ultrafine particle toxicity. Environ Health Perspect. 2004 Oct; 112(14):1347-58. Xia T, Korge P, Weiss JN, Li N, Venkatesen MI, Sioutas C, Nel A. PMID: 15471724; PMCID: PMC1247559.

View in: PubMed Mentions: 102 Fields:
Env Environmental Health
Translation:Animals Cells