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Haake, David A

Title(s)Professor-in-Residence, Medicine
Phone310-268-3814, 310-268-3022
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    Title(s)Professor-in-Residence, Mimg

    Title(s)Professor-in-Residence, Urology


    Collapse Research 
    Collapse Research Activities and Funding
    2017 Scientific Meeting of the International Leptospirosis Society
    NIH/NIAID R13AI133972Nov 21, 2017 - Oct 31, 2018
    Role: Principal Investigator
    Virulence Proteins of Pathogenic Leptospira Species
    NIH/NIAID R21AI128560Jul 1, 2017 - Jun 30, 2019
    Role: Principal Investigator
    Rapid identification and antibiotic susceptibility testing of sepsis pathogens
    NIH/NIAID R21AI109889Jul 1, 2014 - Jun 30, 2016
    Role: Principal Investigator
    The Leptospiral Outer Membrane Proteome & Immunity
    VA I01BX002003Jan 1, 2014 - Mar 31, 2023
    Role: Principal Investigator
    International Leptospirosis Society Meeting 2013
    NIH/NIAID R13AI108190Aug 21, 2013 - Jul 31, 2014
    Role: Principal Investigator
    2012 Biology of Spirochetes Gordon Research Conference
    NIH/NIAID R13AI098121Jan 9, 2012 - Dec 31, 2012
    Role: Principal Investigator
    2009 Spirochetes, Biology of
    NIH/NIAID R13AI085595Oct 1, 2009 - Feb 28, 2011
    Role: Principal Investigator
    2008 Spirochetes Gordon Research Conference
    NIH/NIAID R13AI075924Dec 15, 2007 - Nov 30, 2008
    Role: Principal Investigator
    Sensor Technology for Rapid Microbial Identification and Susceptibility Testing
    NIH/NIAID U01AI075565Jul 1, 2007 - Jun 30, 2014
    Role: Principal Investigator
    2006 Spirochetes, Biology of Gordon Research Conference
    NIH/NIAID R13AI068380Apr 1, 2006 - Mar 31, 2007
    Role: Principal Investigator
    Outer Membrane Proteins of Pathogenic Leptospira Species
    NIH/NIAID R01AI034431May 1, 1996 - Mar 31, 2012
    Role: Principal Investigator
    OUTER MEMBRANE PROTEINS OF PATHOGENIC LEPTOSPIRA SPECIES
    NIH/NIAID R21AI034431May 1, 1996 - Apr 30, 2003
    Role: Principal Investigator
    OUTER MEMBRANE PROTEINS OF PATHOGENIC LEPTOSPIRA SPECIES
    NIH/NIAID R29AI034431May 1, 1996 - Apr 30, 2001
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Markowitz MA, Monti GK, Kim JH, Haake DA. Rapid diagnostic testing in the management of urinary tract infection: Potentials and limitations. Diagn Microbiol Infect Dis. 2019 Aug; 94(4):371-377. PMID: 30928179.
      View in: PubMed
    2. Matsunaga J, Haake DA. cis-Acting Determinant Limiting Expression of Sphingomyelinase Gene sph2 in Leptospira interrogans, Identified with a gfp Reporter Plasmid. Appl Environ Microbiol. 2018 12 01; 84(23). PMID: 30266732.
      View in: PubMed
    3. Markowitz MA, Wood LN, Raz S, Miller LG, Haake DA, Kim JH. Lack of uniformity among United States recommendations for diagnosis and management of acute, uncomplicated cystitis. Int Urogynecol J. 2019 07; 30(7):1187-1194. PMID: 30099566.
      View in: PubMed
    4. Haake DA, Zückert WR. Spirochetal Lipoproteins in Pathogenesis and Immunity. Curr Top Microbiol Immunol. 2018; 415:239-271. PMID: 29196824.
      View in: PubMed
    5. Lourdault K, Matsunaga J, Evangelista KV, Haake DA. High-throughput Parallel Sequencing to Measure Fitness of Leptospira interrogans Transposon Insertion Mutants During Golden Syrian Hamster Infection. J Vis Exp. 2017 12 18; (130). PMID: 29286406.
      View in: PubMed
    6. Ratet G, Santecchia I, Fanton d'Andon M, Vernel-Pauillac F, Wheeler R, Lenormand P, Fischer F, Lechat P, Haake DA, Picardeau M, Boneca IG, Werts C. LipL21 lipoprotein binding to peptidoglycan enables Leptospira interrogans to escape NOD1 and NOD2 recognition. PLoS Pathog. 2017 12; 13(12):e1006725. PMID: 29211798.
      View in: PubMed
    7. Evangelista KV, Lourdault K, Matsunaga J, Haake DA. Immunoprotective properties of recombinant LigA and LigB in a hamster model of acute leptospirosis. PLoS One. 2017; 12(7):e0180004. PMID: 28704385.
      View in: PubMed
    8. Lourdault K, Matsunaga J, Haake DA. High-Throughput Parallel Sequencing to Measure Fitness of Leptospira interrogans Transposon Insertion Mutants during Acute Infection. PLoS Negl Trop Dis. 2016 Nov; 10(11):e0005117. PMID: 27824878.
      View in: PubMed
    9. Wunder EA, Figueira CP, Santos GR, Lourdault K, Matthias MA, Vinetz JM, Ramos E, Haake DA, Picardeau M, Dos Reis MG, Ko AI. Real-Time PCR Reveals Rapid Dissemination of Leptospira interrogans after Intraperitoneal and Conjunctival Inoculation of Hamsters. Infect Immun. 2016 Jul; 84(7):2105-2115. PMID: 27141082.
      View in: PubMed
    10. Fouts DE, Matthias MA, Adhikarla H, Adler B, Amorim-Santos L, Berg DE, Bulach D, Buschiazzo A, Chang YF, Galloway RL, Haake DA, Haft DH, Hartskeerl R, Ko AI, Levett PN, Matsunaga J, Mechaly AE, Monk JM, Nascimento AL, Nelson KE, Palsson B, Peacock SJ, Picardeau M, Ricaldi JN, Thaipandungpanit J, Wunder EA, Yang XF, Zhang JJ, Vinetz JM. What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira. PLoS Negl Trop Dis. 2016 Feb; 10(2):e0004403. PMID: 26890609.
      View in: PubMed
    11. Haake DA. The Miller Hypothesis. For Immunopathol Dis Therap. 2016; 7(3-4):167-174. PMID: 30701122.
      View in: PubMed
    12. Narayanavari SA, Lourdault K, Sritharan M, Haake DA, Matsunaga J. Role of sph2 Gene Regulation in Hemolytic and Sphingomyelinase Activities Produced by Leptospira interrogans. PLoS Negl Trop Dis. 2015; 9(8):e0003952. PMID: 26274394.
      View in: PubMed
    13. Scott VC, Haake DA, Churchill BM, Justice SS, Kim JH. Intracellular Bacterial Communities: A Potential Etiology for Chronic Lower Urinary Tract Symptoms. Urology. 2015 Sep; 86(3):425-31. PMID: 26189137.
      View in: PubMed
    14. Haake DA, Levett PN. Leptospirosis in humans. Curr Top Microbiol Immunol. 2015; 387:65-97. PMID: 25388133.
      View in: PubMed
    15. Haake DA, Zückert WR. The leptospiral outer membrane. Curr Top Microbiol Immunol. 2015; 387:187-221. PMID: 25388136.
      View in: PubMed
    16. Coutinho ML, Matsunaga J, Wang LC, de la Peña Moctezuma A, Lewis MS, Babbitt JT, Aleixo JA, Haake DA. Kinetics of Leptospira interrogans infection in hamsters after intradermal and subcutaneous challenge. PLoS Negl Trop Dis. 2014 Nov; 8(11):e3307. PMID: 25411782.
      View in: PubMed
    17. Witchell TD, Eshghi A, Nally JE, Hof R, Boulanger MJ, Wunder EA, Ko AI, Haake DA, Cameron CE. Post-translational modification of LipL32 during Leptospira interrogans infection. PLoS Negl Trop Dis. 2014 Oct; 8(10):e3280. PMID: 25356675.
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    18. Evangelista KV, Hahn B, Wunder EA, Ko AI, Haake DA, Coburn J. Identification of cell-binding adhesins of Leptospira interrogans. PLoS Negl Trop Dis. 2014 Oct; 8(10):e3215. PMID: 25275630.
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    19. Kothari A, Morgan M, Haake DA. Emerging technologies for rapid identification of bloodstream pathogens. Clin Infect Dis. 2014 Jul 15; 59(2):272-8. PMID: 24771332.
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    20. Lourdault K, Wang LC, Vieira A, Matsunaga J, Melo R, Lewis MS, Haake DA, Gomes-Solecki M. Oral immunization with Escherichia coli expressing a lipidated form of LigA protects hamsters against challenge with Leptospira interrogans serovar Copenhageni. Infect Immun. 2014 Feb; 82(2):893-902. PMID: 24478102.
      View in: PubMed
    21. Matsunaga J, Schlax PJ, Haake DA. Role for cis-acting RNA sequences in the temperature-dependent expression of the multiadhesive lig proteins in Leptospira interrogans. J Bacteriol. 2013 Nov; 195(22):5092-101. PMID: 24013626.
      View in: PubMed
    22. Halford C, Gau V, Churchill BM, Haake DA. Bacterial detection & identification using electrochemical sensors. J Vis Exp. 2013 Apr 23; (74):e4282. PMID: 23644406.
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    23. Pinne M, Haake DA. LipL32 Is a Subsurface Lipoprotein of Leptospira interrogans: presentation of new data and reevaluation of previous studies. PLoS One. 2013; 8(1):e51025. PMID: 23323152.
      View in: PubMed
    24. Halford C, Gonzalez R, Campuzano S, Hu B, Babbitt JT, Liu J, Wang J, Churchill BM, Haake DA. Rapid antimicrobial susceptibility testing by sensitive detection of precursor rRNA using a novel electrochemical biosensing platform. Antimicrob Agents Chemother. 2013 Feb; 57(2):936-43. PMID: 23229486.
      View in: PubMed
    25. Pinne M, Matsunaga J, Haake DA. Leptospiral outer membrane protein microarray, a novel approach to identification of host ligand-binding proteins. J Bacteriol. 2012 Nov; 194(22):6074-87. PMID: 22961849.
      View in: PubMed
    26. Lambert A, Picardeau M, Haake DA, Sermswan RW, Srikram A, Adler B, Murray GA. FlaA proteins in Leptospira interrogans are essential for motility and virulence but are not required for formation of the flagellum sheath. Infect Immun. 2012 Jun; 80(6):2019-25. PMID: 22451522.
      View in: PubMed
    27. Narayanavari SA, Sritharan M, Haake DA, Matsunaga J. Multiple leptospiral sphingomyelinases (or are there?). Microbiology. 2012 May; 158(Pt 5):1137-1146. PMID: 22422753.
      View in: PubMed
    28. Verma A, Matsunaga J, Artiushin S, Pinne M, Houwers DJ, Haake DA, Stevenson B, Timoney JF. Antibodies to a novel leptospiral protein, LruC, in the eye fluids and sera of horses with Leptospira-associated uveitis. Clin Vaccine Immunol. 2012 Mar; 19(3):452-6. PMID: 22237897.
      View in: PubMed
    29. Raddi G, Morado DR, Yan J, Haake DA, Yang XF, Liu J. Three-dimensional structures of pathogenic and saprophytic Leptospira species revealed by cryo-electron tomography. J Bacteriol. 2012 Mar; 194(6):1299-306. PMID: 22228733.
      View in: PubMed
    30. Eshghi A, Pinne M, Haake DA, Zuerner RL, Frank A, Cameron CE. Methylation and in vivo expression of the surface-exposed Leptospira interrogans outer-membrane protein OmpL32. Microbiology. 2012 Mar; 158(Pt 3):622-635. PMID: 22174381.
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    31. Coutinho ML, Choy HA, Kelley MM, Matsunaga J, Babbitt JT, Lewis MS, Aleixo JA, Haake DA. A LigA three-domain region protects hamsters from lethal infection by Leptospira interrogans. PLoS Negl Trop Dis. 2011 Dec; 5(12):e1422. PMID: 22180800.
      View in: PubMed
    32. Patel M, Gonzalez R, Halford C, Lewinski MA, Landaw EM, Churchill BM, Haake DA. Target-specific capture enhances sensitivity of electrochemical detection of bacterial pathogens. J Clin Microbiol. 2011 Dec; 49(12):4293-6. PMID: 21940468.
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    33. Pinne M, Haake D. Immuno-fluorescence assay of leptospiral surface-exposed proteins. J Vis Exp. 2011 Jul 01; (53). PMID: 21750491.
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    34. Kuralay F, Campuzano S, Haake DA, Wang J. Highly sensitive disposable nucleic acid biosensors for direct bioelectronic detection in raw biological samples. Talanta. 2011 Sep 15; 85(3):1330-7. PMID: 21807191.
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    35. Figueira CP, Croda J, Choy HA, Haake DA, Reis MG, Ko AI, Picardeau M. Heterologous expression of pathogen-specific genes ligA and ligB in the saprophyte Leptospira biflexa confers enhanced adhesion to cultured cells and fibronectin. BMC Microbiol. 2011 Jun 09; 11:129. PMID: 21658265.
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    36. Barragan VA, Mejia ME, Trávez A, Zapata S, Hartskeerl RA, Haake DA, Trueba GA. Interactions of leptospira with environmental bacteria from surface water. Curr Microbiol. 2011 Jun; 62(6):1802-6. PMID: 21479795.
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    37. Campuzano S, Kuralay F, Lobo-Castañón MJ, Bartošík M, Vyavahare K, Palecek E, Haake DA, Wang J. Ternary monolayers as DNA recognition interfaces for direct and sensitive electrochemical detection in untreated clinical samples. Biosens Bioelectron. 2011 Apr 15; 26(8):3577-83. PMID: 21377347.
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    38. Choy HA, Kelley MM, Croda J, Matsunaga J, Babbitt JT, Ko AI, Picardeau M, Haake DA. The multifunctional LigB adhesin binds homeostatic proteins with potential roles in cutaneous infection by pathogenic Leptospira interrogans. PLoS One. 2011 Feb 09; 6(2):e16879. PMID: 21347378.
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    39. Walter A, Wu J, Flechsig GU, Haake DA, Wang J. Redox cycling amplified electrochemical detection of DNA hybridization: application to pathogen E. coli bacterial RNA. Anal Chim Acta. 2011 Mar 09; 689(1):29-33. PMID: 21338752.
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    40. Navarro A, Taylor ZD, Beenhouwer D, Haake DA, Gupta V, Grundfest WS. Laser induced shockwaves on flexible polymers for treatment of bacterial biofilms. Stud Health Technol Inform. 2011; 163:394-6. PMID: 21335826.
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    41. Wu J, Campuzano S, Halford C, Haake DA, Wang J. Ternary surface monolayers for ultrasensitive (zeptomole) amperometric detection of nucleic acid hybridization without signal amplification. Anal Chem. 2010 Nov 01; 82(21):8830-7. PMID: 20883023.
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    42. Pinne M, Choy HA, Haake DA. The OmpL37 surface-exposed protein is expressed by pathogenic Leptospira during infection and binds skin and vascular elastin. PLoS Negl Trop Dis. 2010 Sep 07; 4(9):e815. PMID: 20844573.
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    43. Lo M, Murray GL, Khoo CA, Haake DA, Zuerner RL, Adler B. Transcriptional response of Leptospira interrogans to iron limitation and characterization of a PerR homolog. Infect Immun. 2010 Nov; 78(11):4850-9. PMID: 20805337.
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    44. Haake DA, Matsunaga J. Leptospira: a spirochaete with a hybrid outer membrane. Mol Microbiol. 2010 Aug; 77(4):805-14. PMID: 20598085.
      View in: PubMed
    45. Taylor ZD, Navarro A, Kealey CP, Beenhouwer D, Haake DA, Grundfest WS, Gupta V. Bacterial biofilm disruption using laser generated shockwaves. Conf Proc IEEE Eng Med Biol Soc. 2010; 2010:1028-32. PMID: 21096997.
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    46. Wu J, Chumbimuni-Torres KY, Galik M, Thammakhet C, Haake DA, Wang J. Potentiometric detection of DNA hybridization using enzyme-induced metallization and a silver ion selective electrode. Anal Chem. 2009 Dec 15; 81(24):10007-12. PMID: 19908886.
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    47. Lawi W, Wiita C, Snyder ST, Wei F, Wong D, Wong PK, Liao JC, Haake D, Gau V. A Microfluidic Cartridge System for Multiplexed Clinical Analysis. JALA Charlottesv Va. 2009 Dec 01; 14(6):407-412. PMID: 20161584.
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    48. Mach KE, Du CB, Phull H, Haake DA, Shih MC, Baron EJ, Liao JC. Multiplex pathogen identification for polymicrobial urinary tract infections using biosensor technology: a prospective clinical study. J Urol. 2009 Dec; 182(6):2735-41. PMID: 19837423.
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    49. Pinne M, Haake DA. A comprehensive approach to identification of surface-exposed, outer membrane-spanning proteins of Leptospira interrogans. PLoS One. 2009 Jun 29; 4(6):e6071. PMID: 19562037.
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    50. Davis JM, Haake DA, Ramakrishnan L. Leptospira interrogans stably infects zebrafish embryos, altering phagocyte behavior and homing to specific tissues. PLoS Negl Trop Dis. 2009 Jun 23; 3(6):e463. PMID: 19547748.
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    51. McBride AJ, Cerqueira GM, Suchard MA, Moreira AN, Zuerner RL, Reis MG, Haake DA, Ko AI, Dellagostin OA. Genetic diversity of the Leptospiral immunoglobulin-like (Lig) genes in pathogenic Leptospira spp. Infect Genet Evol. 2009 Mar; 9(2):196-205. PMID: 19028604.
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    52. Tabibian JH, Gornbein J, Heidari A, Dien SL, Lau VH, Chahal P, Churchill BM, Haake DA. Uropathogens and host characteristics. J Clin Microbiol. 2008 Dec; 46(12):3980-6. PMID: 18842936.
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    53. Mastali M, Babbitt JT, Li Y, Landaw EM, Gau V, Churchill BM, Haake DA. Optimal probe length and target location for electrochemical detection of selected uropathogens at ambient temperature. J Clin Microbiol. 2008 Aug; 46(8):2707-16. PMID: 18562584.
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    54. Ma Y, Sun CP, Fields M, Li Y, Haake DA, Churchill BM, Ho CM. An unsteady microfluidic T-form mixer perturbed by hydrodynamic pressure. J Micromech Microeng. 2008 Mar 06; 18:45015. PMID: 19177174.
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    55. Ivancic V, Mastali M, Percy N, Gornbein J, Babbitt JT, Li Y, Landaw EM, Bruckner DA, Churchill BM, Haake DA. Rapid antimicrobial susceptibility determination of uropathogens in clinical urine specimens by use of ATP bioluminescence. J Clin Microbiol. 2008 Apr; 46(4):1213-9. PMID: 18272708.
      View in: PubMed
    56. Doungchawee G, Kositanont U, Niwetpathomwat A, Inwisai T, Sagarasaeranee P, Haake DA. Early diagnosis of leptospirosis by immunoglobulin M immunoblot testing. Clin Vaccine Immunol. 2008 Mar; 15(3):492-8. PMID: 18184827.
      View in: PubMed
    57. Stevenson B, Choy HA, Pinne M, Rotondi ML, Miller MC, Demoll E, Kraiczy P, Cooley AE, Creamer TP, Suchard MA, Brissette CA, Verma A, Haake DA. Leptospira interrogans endostatin-like outer membrane proteins bind host fibronectin, laminin and regulators of complement. PLoS One. 2007 Nov 14; 2(11):e1188. PMID: 18000555.
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    58. Silva EF, Medeiros MA, McBride AJ, Matsunaga J, Esteves GS, Ramos JG, Santos CS, Croda J, Homma A, Dellagostin OA, Haake DA, Reis MG, Ko AI. The terminal portion of leptospiral immunoglobulin-like protein LigA confers protective immunity against lethal infection in the hamster model of leptospirosis. Vaccine. 2007 Aug 14; 25(33):6277-86. PMID: 17629368.
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    59. Liao JC, Mastali M, Li Y, Gau V, Suchard MA, Babbitt J, Gornbein J, Landaw EM, McCabe ER, Churchill BM, Haake DA. Development of an advanced electrochemical DNA biosensor for bacterial pathogen detection. J Mol Diagn. 2007 Apr; 9(2):158-68. PMID: 17384207.
      View in: PubMed
    60. Matsunaga J, Lo M, Bulach DM, Zuerner RL, Adler B, Haake DA. Response of Leptospira interrogans to physiologic osmolarity: relevance in signaling the environment-to-host transition. Infect Immun. 2007 Jun; 75(6):2864-74. PMID: 17371863.
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    61. Croda J, Ramos JG, Matsunaga J, Queiroz A, Homma A, Riley LW, Haake DA, Reis MG, Ko AI. Leptospira immunoglobulin-like proteins as a serodiagnostic marker for acute leptospirosis. J Clin Microbiol. 2007 May; 45(5):1528-34. PMID: 17360842.
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    62. Choy HA, Kelley MM, Chen TL, Møller AK, Matsunaga J, Haake DA. Physiological osmotic induction of Leptospira interrogans adhesion: LigA and LigB bind extracellular matrix proteins and fibrinogen. Infect Immun. 2007 May; 75(5):2441-50. PMID: 17296754.
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    63. Matsunaga J, Werneid K, Zuerner RL, Frank A, Haake DA. LipL46 is a novel surface-exposed lipoprotein expressed during leptospiral dissemination in the mammalian host. Microbiology. 2006 Dec; 152(Pt 12):3777-3786. PMID: 17159228.
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    64. Lo M, Bulach DM, Powell DR, Haake DA, Matsunaga J, Paustian ML, Zuerner RL, Adler B. Effects of temperature on gene expression patterns in Leptospira interrogans serovar Lai as assessed by whole-genome microarrays. Infect Immun. 2006 Oct; 74(10):5848-59. PMID: 16988264.
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    65. Haake DA. Hamster model of leptospirosis. Curr Protoc Microbiol. 2006 Sep; Chapter 12:Unit 12E.2. PMID: 18770576.
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    66. Szeredi L, Haake DA. Immunohistochemical identification and pathologic findings in natural cases of equine abortion caused by leptospiral infection. Vet Pathol. 2006 Sep; 43(5):755-61. PMID: 16966455.
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    67. Haake DA. Molecular epidemiology of leptospirosis in the Amazon. PLoS Med. 2006 Aug; 3(8):e302. PMID: 16933961.
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    68. Liao JC, Mastali M, Gau V, Suchard MA, Møller AK, Bruckner DA, Babbitt JT, Li Y, Gornbein J, Landaw EM, McCabe ER, Churchill BM, Haake DA. Use of electrochemical DNA biosensors for rapid molecular identification of uropathogens in clinical urine specimens. J Clin Microbiol. 2006 Feb; 44(2):561-70. PMID: 16455913.
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    69. Setubal JC, Reis M, Matsunaga J, Haake DA. Lipoprotein computational prediction in spirochaetal genomes. Microbiology. 2006 Jan; 152(Pt 1):113-121. PMID: 16385121.
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    70. Verma A, Artiushin S, Matsunaga J, Haake DA, Timoney JF. LruA and LruB, novel lipoproteins of pathogenic Leptospira interrogans associated with equine recurrent uveitis. Infect Immun. 2005 Nov; 73(11):7259-66. PMID: 16239521.
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    71. Gau V, Ma SC, Wang H, Tsukuda J, Kibler J, Haake DA. Electrochemical molecular analysis without nucleic acid amplification. Methods. 2005 Sep; 37(1):73-83. PMID: 16213156.
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    72. Narita M, Fujitani S, Haake DA, Paterson DL. Leptospirosis after recreational exposure to water in the Yaeyama islands, Japan. Am J Trop Med Hyg. 2005 Oct; 73(4):652-6. PMID: 16222003.
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    73. Cullen PA, Xu X, Matsunaga J, Sanchez Y, Ko AI, Haake DA, Adler B. Surfaceome of Leptospira spp. Infect Immun. 2005 Aug; 73(8):4853-63. PMID: 16040999.
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    74. Haake DA, Matsunaga J. Leptospiral membrane proteins--variations on a theme? Indian J Med Res. 2005 Mar; 121(3):143-5. PMID: 15802754.
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    75. Spudick JM, Garcia LS, Graham DM, Haake DA. Diagnostic and therapeutic pitfalls associated with primaquine-tolerant Plasmodium vivax. J Clin Microbiol. 2005 Feb; 43(2):978-81. PMID: 15695723.
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    76. Matsunaga J, Sanchez Y, Xu X, Haake DA. Osmolarity, a key environmental signal controlling expression of leptospiral proteins LigA and LigB and the extracellular release of LigA. Infect Immun. 2005 Jan; 73(1):70-8. PMID: 15618142.
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    77. Reyes EA, Cullen P, Bulach D, Adler B, Haake D, de la Peña-Moctezuma A. [Expression in Escherichia coli of the gspd(l) gene of the type II secretion system in Leptospira borgpetersenii serovariety hardjo]. Rev Cubana Med Trop. 2005 Jan-Apr; 57(1):45-6. PMID: 17966476.
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    78. Sun CP, Liao JC, Zhang YH, Gau V, Mastali M, Babbitt JT, Grundfest WS, Churchill BM, McCabe ER, Haake DA. Rapid, species-specific detection of uropathogen 16S rDNA and rRNA at ambient temperature by dot-blot hybridization and an electrochemical sensor array. Mol Genet Metab. 2005 Jan; 84(1):90-9. PMID: 15639199.
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    79. Cullen PA, Haake DA, Adler B. Outer membrane proteins of pathogenic spirochetes. FEMS Microbiol Rev. 2004 Jun; 28(3):291-318. PMID: 15449605.
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    80. Haake DA, Suchard MA, Kelley MM, Dundoo M, Alt DP, Zuerner RL. Molecular evolution and mosaicism of leptospiral outer membrane proteins involves horizontal DNA transfer. J Bacteriol. 2004 May; 186(9):2818-28. PMID: 15090524.
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    81. Nascimento AL, Ko AI, Martins EA, Monteiro-Vitorello CB, Ho PL, Haake DA, Verjovski-Almeida S, Hartskeerl RA, Marques MV, Oliveira MC, Menck CF, Leite LC, Carrer H, Coutinho LL, Degrave WM, Dellagostin OA, El-Dorry H, Ferro ES, Ferro MI, Furlan LR, Gamberini M, Giglioti EA, Góes-Neto A, Goldman GH, Goldman MH, Harakava R, Jerônimo SM, Junqueira-de-Azevedo IL, Kimura ET, Kuramae EE, Lemos EG, Lemos MV, Marino CL, Nunes LR, de Oliveira RC, Pereira GG, Reis MS, Schriefer A, Siqueira WJ, Sommer P, Tsai SM, Simpson AJ, Ferro JA, Camargo LE, Kitajima JP, Setubal JC, Van Sluys MA. Comparative genomics of two Leptospira interrogans serovars reveals novel insights into physiology and pathogenesis. J Bacteriol. 2004 Apr; 186(7):2164-72. PMID: 15028702.
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    82. Nascimento AL, Verjovski-Almeida S, Van Sluys MA, Monteiro-Vitorello CB, Camargo LE, Digiampietri LA, Harstkeerl RA, Ho PL, Marques MV, Oliveira MC, Setubal JC, Haake DA, Martins EA. Genome features of Leptospira interrogans serovar Copenhageni. Braz J Med Biol Res. 2004 Apr; 37(4):459-77. PMID: 15064809.
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    83. Trueba G, Zapata S, Madrid K, Cullen P, Haake D. Cell aggregation: a mechanism of pathogenic Leptospira to survive in fresh water. Int Microbiol. 2004 Mar; 7(1):35-40. PMID: 15179605.
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    84. Matsunaga J, Barocchi MA, Croda J, Young TA, Sanchez Y, Siqueira I, Bolin CA, Reis MG, Riley LW, Haake DA, Ko AI. Pathogenic Leptospira species express surface-exposed proteins belonging to the bacterial immunoglobulin superfamily. Mol Microbiol. 2003 Aug; 49(4):929-45. PMID: 12890019.
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    85. Cullen PA, Haake DA, Bulach DM, Zuerner RL, Adler B. LipL21 is a novel surface-exposed lipoprotein of pathogenic Leptospira species. Infect Immun. 2003 May; 71(5):2414-21. PMID: 12704111.
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    86. Haake DA, Matsunaga J. Characterization of the leptospiral outer membrane and description of three novel leptospiral membrane proteins. Infect Immun. 2002 Sep; 70(9):4936-45. PMID: 12183539.
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