Joshua I Goldhaber

Title(s)Professor-in-Residence, Medicine
SchoolMedicine
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    Calcium Regulation in Heart Failure with Preserved versus Reduced Ejection Fraction
    NIH R01HL147570Aug 1, 2019 - May 31, 2023
    Role: Principal Investigator
    Regulation of cellular calcium by cardiac sodium-calcium exchange
    NIH R01HL147569Apr 15, 2019 - Feb 28, 2023
    Role: Principal Investigator
    Biological pacemaker from proof-of-concept to clinic
    NIH R01HL135866Dec 27, 2016 - Nov 30, 2021
    Role: Co-Principal Investigator
    Training in Advanced Heart Disease Research
    NIH T32HL116273Aug 1, 2013 - Jul 31, 2023
    Role: Co-Principal Investigator
    Calcium Signaling, Metabolism, and EC Coupling in Heart
    NIH R01HL070828Jul 15, 2002 - Dec 31, 2014
    Role: Principal Investigator
    Calcium Signaling, Metabolism, and EC Coupling in Heart
    NIH R56HL070828Jul 15, 2002 - Jul 31, 2009
    Role: Principal Investigator
    MEDIATORS OF CARDIAC INJURY
    NIH R29HL051129Mar 1, 1996 - Feb 28, 2001
    Role: Principal Investigator
    Cellular Biology of Cardiac Sodium-Calcium Exchange
    NIH R01HL048509Sep 30, 1992 - Jan 31, 2019
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Dual network structure of the AV node. ArXiv. 2024 May 30. Maltsev AV, Barlas YZ, Hazan A, Zhang R, Ottolia M, Goldhaber JI. PMID: 38827454; PMCID: PMC11142317.
      View in: PubMed   Mentions:
    2. Sympathetic toggled paroxysmal atrial fibrillation and recurrent premature atrial contractions in ambulatory patients. Heart Rhythm. 2024 09; 21(9):1669-1676. Hwang D, Liu X, Kote A, Reaso J, Andersson KT, Shehata MM, Ehdaie A, Wang X, Cingolani E, Ramireddy A, Braunstein ED, Chen LS, Li X, Goldhaber JI, Chen PS. PMID: 38762134; PMCID: PMC11365759.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Cardiac function is regulated by the sodium-dependent inhibition of the sodium-calcium exchanger NCX1. Nat Commun. 2024 May 07; 15(1):3831. Scranton K, John S, Angelini M, Steccanella F, Umar S, Zhang R, Goldhaber JI, Olcese R, Ottolia M. PMID: 38714663; PMCID: PMC11076594.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    4. Reverse electrical remodeling in rats with heart failure and preserved ejection fraction. JCI Insight. 2023 07 10; 8(13). Cho JH, Kilfoil PJ, Zhang R, Solymani RE, Bresee C, Kang EM, Luther K, Rogers RG, de Couto G, Goldhaber JI, Marbán E, Cingolani E. PMID: 37427587; PMCID: PMC10371331.
      View in: PubMed   Mentions:    Fields:    
    5. Increased in vivo perpetuation of whole-heart ventricular arrhythmia in heterozygous Na+/Ca2+ exchanger knockout mice. Int J Cardiol Heart Vasc. 2023 Feb; 44:101168. Bögeholz N, Knappe V, Pauls P, Schulte JS, Goldhaber JI, Müller FU, Nickenig G, Eckardt L, Schrickel JW, Beiert T. PMID: 36620202; PMCID: PMC9816773.
      View in: PubMed   Mentions: 2  
    6. Sympathetic toggled sinus rate acceleration as a mechanism of sustained sinus tachycardia in chronic orthostatic intolerance syndrome. Heart Rhythm. 2022 12; 19(12):2086-2094. Hwang D, Liu X, Rosenberg C, Lee A, Borle S, Ricafrente JQ, Wei J, Shufelt C, Chen LS, Li X, Goldhaber JI, Bairey Merz CN, Chen PS. PMID: 35995322.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    7. Delayed intrinsicoid deflection: Electrocardiographic harbinger of heart disease. Ann Noninvasive Electrocardiol. 2022 05; 27(3):e12940. Aiken AV, Goldhaber JI, Chugh SS. PMID: 35176188; PMCID: PMC9107081.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    8. The Cardiac Na+ -Ca2+ Exchanger: From Structure to Function. Compr Physiol. 2021 12 29; 12(1):2681-2717. Ottolia M, John S, Hazan A, Goldhaber JI. PMID: 34964124; PMCID: PMC8773166.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    9. Mechanisms of Sinoatrial Node Dysfunction in Heart Failure With Preserved Ejection Fraction. Circulation. 2022 01 04; 145(1):45-60. Mesquita T, Zhang R, Cho JH, Zhang R, Lin YN, Sanchez L, Goldhaber JI, Yu JK, Liang JA, Liu W, Trayanova NA, Cingolani E. PMID: 34905696; PMCID: PMC9083886.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    10. Understanding Circadian Mechanisms of Sudden Cardiac Death: A Report From the National Heart, Lung, and Blood Institute Workshop, Part 1: Basic and Translational Aspects. Circ Arrhythm Electrophysiol. 2021 11; 14(11):e010181. Delisle BP, George AL, Nerbonne JM, Bass JT, Ripplinger CM, Jain MK, Hermanstyne TO, Young ME, Kannankeril PJ, Duffy JF, Goldhaber JI, Hall MH, Somers VK, Smolensky MH, Garnett CE, Anafi RC, Scheer FAJL, Shivkumar K, Shea SA, Balijepalli RC. PMID: 34719240; PMCID: PMC8815462.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    11. Understanding Circadian Mechanisms of Sudden Cardiac Death: A Report From the National Heart, Lung, and Blood Institute Workshop, Part 2: Population and Clinical Considerations. Circ Arrhythm Electrophysiol. 2021 11; 14(11):e010190. Delisle BP, George AL, Nerbonne JM, Bass JT, Ripplinger CM, Jain MK, Hermanstyne TO, Young ME, Kannankeril PJ, Duffy JF, Goldhaber JI, Hall MH, Somers VK, Smolensky MH, Garnett CE, Anafi RC, Scheer FAJL, Shivkumar K, Shea SA, Balijepalli RC. PMID: 34719257; PMCID: PMC8865094.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansPHPublic Health
    12. Myofilament Phosphorylation in Stem Cell Treated Diastolic Heart Failure. Circ Res. 2021 12 03; 129(12):1125-1140. Soetkamp D, Gallet R, Parker SJ, Holewinski R, Venkatraman V, Peck K, Goldhaber JI, Marbán E, Van Eyk JE. PMID: 34641704; PMCID: PMC8666591.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    13. Acute Genetic Ablation of Cardiac Sodium/Calcium Exchange in Adult Mice: Implications for Cardiomyocyte Calcium Regulation, Cardioprotection, and Arrhythmia. J Am Heart Assoc. 2021 09 07; 10(17):e019273. Lotteau S, Zhang R, Hazan A, Grabar C, Gonzalez D, Aynaszyan S, Philipson KD, Ottolia M, Goldhaber JI. PMID: 34472363; PMCID: PMC8649274.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    14. Distinct features of calcium handling and β-adrenergic sensitivity in heart failure with preserved versus reduced ejection fraction. J Physiol. 2020 11; 598(22):5091-5108. Kilfoil PJ, Lotteau S, Zhang R, Yue X, Aynaszyan S, Solymani RE, Cingolani E, Marbán E, Goldhaber JI. PMID: 32829489; PMCID: PMC7693093.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    15. Cardiac TRPV1 afferent signaling promotes arrhythmogenic ventricular remodeling after myocardial infarction. JCI Insight. 2020 02 13; 5(3). Yoshie K, Rajendran PS, Massoud L, Mistry J, Swid MA, Wu X, Sallam T, Zhang R, Goldhaber JI, Salavatian S, Ajijola OA. PMID: 31846438; PMCID: PMC7098788.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    16. Na/Ca exchange in the atrium: Role in sinoatrial node pacemaking and excitation-contraction coupling. Cell Calcium. 2020 05; 87:102167. Yue X, Hazan A, Lotteau S, Zhang R, Torrente AG, Philipson KD, Ottolia M, Goldhaber JI. PMID: 32028091; PMCID: PMC7153991.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    17. Canonical Wnt signaling promotes pacemaker cell specification of cardiac mesodermal cells derived from mouse and human embryonic stem cells. Stem Cells. 2020 03; 38(3):352-368. Liang W, Han P, Kim EH, Mak J, Zhang R, Torrente AG, Goldhaber JI, Marbán E, Cho HC. PMID: 31648393; PMCID: PMC7932048.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    18. Modulation of the cardiac Na+-Ca2+ exchanger by cytoplasmic protons: Molecular mechanisms and physiological implications. Cell Calcium. 2020 05; 87:102140. Scranton K, John S, Escobar A, Goldhaber JI, Ottolia M. PMID: 32070924; PMCID: PMC7153995.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    19. Reverse electrical remodeling in rats with heart failure and preserved ejection fraction. JCI Insight. 2018 10 04; 3(19). Cho JH, Kilfoil PJ, Zhang R, Solymani RE, Bresee C, Kang EM, Luther K, Rogers RG, de Couto G, Goldhaber JI, Marbán E, Cingolani E. PMID: 30282820; PMCID: PMC6237473.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    20. Distinct Occurrence of Proarrhythmic Afterdepolarizations in Atrial Versus Ventricular Cardiomyocytes: Implications for Translational Research on Atrial Arrhythmia. Front Pharmacol. 2018; 9:933. Bögeholz N, Pauls P, Dechering DG, Frommeyer G, Goldhaber JI, Pott C, Eckardt L, Müller FU, Schulte JS. PMID: 30186171; PMCID: PMC6111493.
      View in: PubMed   Mentions: 4  
    21. Ventricular Arrhythmias Underlie Sudden Death in Rats With Heart Failure and Preserved Ejection Fraction. Circ Arrhythm Electrophysiol. 2018 08; 11(8):e006452. Cho JH, Zhang R, Aynaszyan S, Holm K, Goldhaber JI, Marbán E, Cingolani E. PMID: 30030266; PMCID: PMC6091890.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    22. Molecular determinants of pH regulation in the cardiac Na+-Ca2+ exchanger. J Gen Physiol. 2018 02 05; 150(2):245-257. John S, Kim B, Olcese R, Goldhaber JI, Ottolia M. PMID: 29301861; PMCID: PMC5806679.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    23. Next-generation pacemakers: from small devices to biological pacemakers. Nat Rev Cardiol. 2018 03; 15(3):139-150. Cingolani E, Goldhaber JI, Marbán E. PMID: 29143810; PMCID: PMC6261336.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimals
    24. Delayed Repolarization Underlies Ventricular Arrhythmias in Rats With Heart Failure and Preserved Ejection Fraction. Circulation. 2017 Nov 21; 136(21):2037-2050. Cho JH, Zhang R, Kilfoil PJ, Gallet R, de Couto G, Bresee C, Goldhaber JI, Marbán E, Cingolani E. PMID: 28974519; PMCID: PMC5698112.
      View in: PubMed   Mentions: 35     Fields:    Translation:Animals
    25. The Effects of SEA0400 on Ca2+ Transient Amplitude and Proarrhythmia Depend on the Na+/Ca2+ Exchanger Expression Level in Murine Models. Front Pharmacol. 2017; 8:649. Bögeholz N, Schulte JS, Kaese S, Bauer BK, Pauls P, Dechering DG, Frommeyer G, Goldhaber JI, Kirchhefer U, Eckardt L, Pott C, Müller FU. PMID: 28983248; PMCID: PMC5613119.
      View in: PubMed   Mentions: 6  
    26. Heterogeneity of transverse-axial tubule system in mouse atria: Remodeling in atrial-specific Na+-Ca2+ exchanger knockout mice. J Mol Cell Cardiol. 2017 07; 108:50-60. Yue X, Zhang R, Kim B, Ma A, Philipson KD, Goldhaber JI. PMID: 28529049; PMCID: PMC5791526.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    27. Contribution of small conductance K+ channels to sinoatrial node pacemaker activity: insights from atrial-specific Na+ /Ca2+ exchange knockout mice. J Physiol. 2017 06 15; 595(12):3847-3865. Torrente AG, Zhang R, Wang H, Zaini A, Kim B, Yue X, Philipson KD, Goldhaber JI. PMID: 28346695; PMCID: PMC5471364.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    28. Triggered activity in atrial myocytes is influenced by Na+/Ca2+ exchanger activity in genetically altered mice. J Mol Cell Cardiol. 2016 Dec; 101:106-115. Bögeholz N, Pauls P, Kaese S, Schulte JS, Lemoine MD, Dechering DG, Frommeyer G, Goldhaber JI, Seidl MD, Kirchhefer U, Eckardt L, Müller FU, Pott C. PMID: 27838371; PMCID: PMC5784756.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    29. Suppression of Early and Late Afterdepolarizations by Heterozygous Knockout of the Na+/Ca2+ Exchanger in a Murine Model. Circ Arrhythm Electrophysiol. 2015 Oct; 8(5):1210-8. Bögeholz N, Pauls P, Bauer BK, Schulte JS, Dechering DG, Frommeyer G, Kirchhefer U, Goldhaber JI, Müller FU, Eckardt L, Pott C. PMID: 26338832.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    30. Burst pacemaker activity of the sinoatrial node in sodium-calcium exchanger knockout mice. Proc Natl Acad Sci U S A. 2015 Aug 04; 112(31):9769-74. Torrente AG, Zhang R, Zaini A, Giani JF, Kang J, Lamp ST, Philipson KD, Goldhaber JI. PMID: 26195795; PMCID: PMC4534240.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    31. Regulation of calcium clock-mediated pacemaking by inositol-1,4,5-trisphosphate receptors in mouse sinoatrial nodal cells. J Physiol. 2015 Jun 15; 593(12):2649-63. Kapoor N, Tran A, Kang J, Zhang R, Philipson KD, Goldhaber JI. PMID: 25903031; PMCID: PMC4500350.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    32. Na+/Ca2+ exchange and Na+/K+-ATPase in the heart. J Physiol. 2015 Mar 15; 593(6):1361-82. Shattock MJ, Ottolia M, Bers DM, Blaustein MP, Boguslavskyi A, Bossuyt J, Bridge JH, Chen-Izu Y, Clancy CE, Edwards A, Goldhaber J, Kaplan J, Lingrel JB, Pavlovic D, Philipson K, Sipido KR, Xie ZJ. PMID: 25772291; PMCID: PMC4376416.
      View in: PubMed   Mentions: 102     Fields:    Translation:HumansAnimalsCells
    33. Mitochondrial Ca(2+) uptake by the voltage-dependent anion channel 2 regulates cardiac rhythmicity. Elife. 2015 Jan 15; 4. Shimizu H, Schredelseker J, Huang J, Lu K, Naghdi S, Lu F, Franklin S, Fiji HD, Wang K, Zhu H, Tian C, Lin B, Nakano H, Ehrlich A, Nakai J, Stieg AZ, Gimzewski JK, Nakano A, Goldhaber JI, Vondriska TM, Hajnóczky G, Kwon O, Chen JN. PMID: 25588501; PMCID: PMC4293673.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    34. Embryonic stem cell-derived cardiac myocytes are not ready for human trials. Circ Res. 2014 Jul 18; 115(3):335-8. Anderson ME, Goldhaber J, Houser SR, Puceat M, Sussman MA. PMID: 24935962; PMCID: PMC4133694.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    35. A modified local control model for Ca2+ transients in cardiomyocytes: junctional flux is accompanied by release from adjacent non-junctional RyRs. J Mol Cell Cardiol. 2014 Mar; 68:1-11. Torres NS, Sachse FB, Izu LT, Goldhaber JI, Spitzer KW, Bridge JH. PMID: 24389341; PMCID: PMC3942534.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    36. Pulseless electric activity: definition, causes, mechanisms, management, and research priorities for the next decade: report from a National Heart, Lung, and Blood Institute workshop. Circulation. 2013 Dec 03; 128(23):2532-41. Myerburg RJ, Halperin H, Egan DA, Boineau R, Chugh SS, Gillis AM, Goldhaber JI, Lathrop DA, Liu P, Niemann JT, Ornato JP, Sopko G, Van Eyk JE, Walcott GP, Weisfeldt ML, Wright JD, Zipes DP. PMID: 24297818.
      View in: PubMed   Mentions: 50     Fields:    Translation:Humans
    37. Complete atrial-specific knockout of sodium-calcium exchange eliminates sinoatrial node pacemaker activity. PLoS One. 2013; 8(11):e81633. Groenke S, Larson ED, Alber S, Zhang R, Lamp ST, Ren X, Nakano H, Jordan MC, Karagueuzian HS, Roos KP, Nakano A, Proenza C, Philipson KD, Goldhaber JI. PMID: 24278453; PMCID: PMC3836769.
      View in: PubMed   Mentions: 38     Fields:    Translation:Animals
    38. Integrins protect cardiomyocytes from ischemia/reperfusion injury. J Clin Invest. 2013 Oct; 123(10):4294-308. Okada H, Lai NC, Kawaraguchi Y, Liao P, Copps J, Sugano Y, Okada-Maeda S, Banerjee I, Schilling JM, Gingras AR, Asfaw EK, Suarez J, Kang SM, Perkins GA, Au CG, Israeli-Rosenberg S, Manso AM, Liu Z, Milner DJ, Kaufman SJ, Patel HH, Roth DM, Hammond HK, Taylor SS, Dillmann WH, Goldhaber JI, Ross RS. PMID: 24091324; PMCID: PMC3784521.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    39. Na/Ca exchange and contraction of the heart. J Mol Cell Cardiol. 2013 Aug; 61:28-33. Ottolia M, Torres N, Bridge JH, Philipson KD, Goldhaber JI. PMID: 23770352; PMCID: PMC3730535.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    40. Cardiac sodium-calcium exchange and efficient excitation-contraction coupling: implications for heart disease. Adv Exp Med Biol. 2013; 961:355-64. Goldhaber JI, Philipson KD. PMID: 23224894; PMCID: PMC3903336.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    41. 20 years from NCX purification and cloning: milestones. Adv Exp Med Biol. 2013; 961:17-23. Nicoll DA, Ottolia M, Goldhaber JI, Philipson KD. PMID: 23224866; PMCID: PMC3903337.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    42. Characterization and therapeutic potential of induced pluripotent stem cell-derived cardiovascular progenitor cells. PLoS One. 2012; 7(10):e45603. Nsair A, Schenke-Layland K, Van Handel B, Evseenko D, Kahn M, Zhao P, Mendelis J, Heydarkhan S, Awaji O, Vottler M, Geist S, Chyu J, Gago-Lopez N, Crooks GM, Plath K, Goldhaber J, Mikkola HK, MacLellan WR. PMID: 23056209; PMCID: PMC3467279.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    43. Proarrhythmia in a non-failing murine model of cardiac-specific Na+/Ca 2+ exchanger overexpression: whole heart and cellular mechanisms. Basic Res Cardiol. 2012 Mar; 107(2):247. Pott C, Muszynski A, Ruhe M, Bögeholz N, Schulte JS, Milberg P, Mönnig G, Fabritz L, Goldhaber JI, Breithardt G, Schmitz W, Philipson KD, Eckardt L, Kirchhof P, Müller FU. PMID: 22327339; PMCID: PMC3500087.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    44. The role of E2F-1 and downstream target genes in mediating ischemia/reperfusion injury in vivo. J Mol Cell Cardiol. 2011 Dec; 51(6):919-26. Angelis E, Zhao P, Zhang R, Goldhaber JI, Maclellan WR. PMID: 21964190; PMCID: PMC3221483.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    45. Triple threat: the Na+/Ca2+ exchanger in the pathophysiology of cardiac arrhythmia, ischemia and heart failure. Curr Drug Targets. 2011 May; 12(5):737-47. Pott C, Eckardt L, Goldhaber JI. PMID: 21291388; PMCID: PMC4406235.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    46. Recapitulation of the embryonic cardiovascular progenitor cell niche. Biomaterials. 2011 Apr; 32(11):2748-56. Schenke-Layland K, Nsair A, Van Handel B, Angelis E, Gluck JM, Votteler M, Goldhaber JI, Mikkola HK, Kahn M, Maclellan WR. PMID: 21257198; PMCID: PMC3414535.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    47. Na+ currents are required for efficient excitation-contraction coupling in rabbit ventricular myocytes: a possible contribution of neuronal Na+ channels. J Physiol. 2010 Nov 01; 588(Pt 21):4249-60. Torres NS, Larbig R, Rock A, Goldhaber JI, Bridge JH. PMID: 20837647; PMCID: PMC3002454.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    48. Sodium-calcium exchange is essential for effective triggering of calcium release in mouse heart. Biophys J. 2010 Aug 04; 99(3):755-64. Neco P, Rose B, Huynh N, Zhang R, Bridge JH, Philipson KD, Goldhaber JI. PMID: 20682252; PMCID: PMC2913203.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    49. Activation of reverse Na+-Ca2+ exchange by the Na+ current augments the cardiac Ca2+ transient: evidence from NCX knockout mice. J Physiol. 2010 Sep 01; 588(Pt 17):3267-76. Larbig R, Torres N, Bridge JH, Goldhaber JI, Philipson KD. PMID: 20643777; PMCID: PMC2976021.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    50. Role of inotropic agents in the treatment of heart failure. Circulation. 2010 Apr 13; 121(14):1655-60. Goldhaber JI, Hamilton MA. PMID: 20385962; PMCID: PMC2861129.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    51. Spontaneously beating cardiomyocytes derived from white mature adipocytes. Cardiovasc Res. 2010 Jan 01; 85(1):17-27. Jumabay M, Zhang R, Yao Y, Goldhaber JI, Boström KI. PMID: 19643806; PMCID: PMC2791054.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    52. Dysfunction of ouabain-induced cardiac contractility in mice with heart-specific ablation of Na,K-ATPase beta1-subunit. J Mol Cell Cardiol. 2009 Oct; 47(4):552-60. Barwe SP, Jordan MC, Skay A, Inge L, Rajasekaran SA, Wolle D, Johnson CL, Neco P, Fang K, Rozengurt N, Goldhaber JI, Roos KP, Rajasekaran AK. PMID: 19683723; PMCID: PMC2749246.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    53. Loss of intracellular and intercellular synchrony of calcium release in systolic heart failure. Circ Heart Fail. 2009 May; 2(3):157-9. Goldhaber JI, Bridge JH. PMID: 19808334; PMCID: PMC2760027.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    54. Towards computational modeling of excitation-contraction coupling in cardiac myocytes: reconstruction of structures and proteins from confocal imaging. Pac Symp Biocomput. 2009; 328-39. Sachse FB, Savio-Galimberti E, Goldhaber JI, Bridge JH. PMID: 19209712; PMCID: PMC3903382.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    55. Novel features of the rabbit transverse tubular system revealed by quantitative analysis of three-dimensional reconstructions from confocal images. Biophys J. 2008 Aug; 95(4):2053-62. Savio-Galimberti E, Frank J, Inoue M, Goldhaber JI, Cannell MB, Bridge JH, Sachse FB. PMID: 18487298; PMCID: PMC2483780.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    56. Reprogrammed mouse fibroblasts differentiate into cells of the cardiovascular and hematopoietic lineages. Stem Cells. 2008 Jun; 26(6):1537-46. Schenke-Layland K, Rhodes KE, Angelis E, Butylkova Y, Heydarkhan-Hagvall S, Gekas C, Zhang R, Goldhaber JI, Mikkola HK, Plath K, MacLellan WR. PMID: 18450826; PMCID: PMC2873147.
      View in: PubMed   Mentions: 87     Fields:    Translation:AnimalsCells
    57. Sub-micrometer anatomical models of the sarcolemma of cardiac myocytes based on confocal imaging. Pac Symp Biocomput. 2008; 390-401. Sachse FB, Savio-Galimberti E, Goldhaber JI, Bridge JH. PMID: 18229702.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    58. Effect of metabolic inhibition on couplon behavior in rabbit ventricular myocytes. Biophys J. 2008 Mar 01; 94(5):1656-66. Chantawansri C, Huynh N, Yamanaka J, Garfinkel A, Lamp ST, Inoue M, Bridge JH, Goldhaber JI. PMID: 18024504; PMCID: PMC2242765.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    59. Gi alpha 1-mediated cardiac electrophysiological remodeling and arrhythmia in hypertrophic cardiomyopathy. Circulation. 2007 Aug 07; 116(6):596-605. Ruan H, Mitchell S, Vainoriene M, Lou Q, Xie LH, Ren S, Goldhaber JI, Wang Y. PMID: 17646583.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    60. Na+/Ca2+ exchanger knockout mice: plasticity of cardiac excitation-contraction coupling. Ann N Y Acad Sci. 2007 Mar; 1099:270-5. Pott C, Henderson SA, Goldhaber JI, Philipson KD. PMID: 17446467.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    61. Homozygous overexpression of the Na+-Ca2+ exchanger in mice: evidence for increased transsarcolemmal Ca2+ fluxes. Ann N Y Acad Sci. 2007 Mar; 1099:310-4. Pott C, Goldhaber JI, Philipson KD. PMID: 17446472.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    62. Regulation of cardiac L-type Ca2+ current in Na+-Ca2+ exchanger knockout mice: functional coupling of the Ca2+ channel and the Na+-Ca2+ exchanger. Biophys J. 2007 Feb 15; 92(4):1431-7. Pott C, Yip M, Goldhaber JI, Philipson KD. PMID: 17114214; PMCID: PMC1783897.
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    63. Mechanism of shortened action potential duration in Na+-Ca2+ exchanger knockout mice. Am J Physiol Cell Physiol. 2007 Feb; 292(2):C968-73. Pott C, Ren X, Tran DX, Yang MJ, Henderson S, Jordan MC, Roos KP, Garfinkel A, Philipson KD, Goldhaber JI. PMID: 16943244.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    64. Is the ryanodine receptor a target for antiarrhythmic therapy? Circ Res. 2006 May 26; 98(10):1232-3. Pott C, Goldhaber JI. PMID: 16728666.
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    65. Movement of vault particles visualized by GFP-tagged major vault protein. Cell Tissue Res. 2006 Jun; 324(3):403-10. Slesina M, Inman EM, Moore AE, Goldhaber JI, Rome LH, Volknandt W. PMID: 16505994.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    66. Mutation in sodium-calcium exchanger 1 (NCX1) causes cardiac fibrillation in zebrafish. Proc Natl Acad Sci U S A. 2005 Dec 06; 102(49):17699-704. Langenbacher AD, Dong Y, Shu X, Choi J, Nicoll DA, Goldhaber JI, Philipson KD, Chen JN. PMID: 16314583; PMCID: PMC1308881.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    67. Excitation-contraction coupling in Na+-Ca2+ exchanger knockout mice: reduced transsarcolemmal Ca2+ flux. Circ Res. 2005 Dec 09; 97(12):1288-95. Pott C, Philipson KD, Goldhaber JI. PMID: 16293789; PMCID: PMC1790864.
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    68. Cardiac-specific ablation of the Na+-Ca2+ exchanger confers protection against ischemia/reperfusion injury. Circ Res. 2005 Oct 28; 97(9):916-21. Imahashi K, Pott C, Goldhaber JI, Steenbergen C, Philipson KD, Murphy E. PMID: 16179590.
      View in: PubMed   Mentions: 63     Fields:    Translation:Animals
    69. Na(+)--Ca2+ exchange in the regulation of cardiac excitation-contraction coupling. Cardiovasc Res. 2005 Aug 01; 67(2):198-207. Reuter H, Pott C, Goldhaber JI, Henderson SA, Philipson KD, Schwinger RH. PMID: 15935336.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    70. Effects of Na+-Ca2+ exchange expression on excitation-contraction coupling in genetically modified mice. Ann N Y Acad Sci. 2005 Jun; 1047:122-6. Goldhaber JI, Henderson SA, Reuter H, Pott C, Philipson KD. PMID: 16093490.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    71. Metabolic inhibition alters subcellular calcium release patterns in rat ventricular myocytes: implications for defective excitation-contraction coupling during cardiac ischemia and failure. Circ Res. 2005 Mar 18; 96(5):551-7. Fukumoto GH, Lamp ST, Motter C, Bridge JH, Garfinkel A, Goldhaber JI. PMID: 15718501.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    72. Action potential duration restitution and alternans in rabbit ventricular myocytes: the key role of intracellular calcium cycling. Circ Res. 2005 Mar 04; 96(4):459-66. Goldhaber JI, Xie LH, Duong T, Motter C, Khuu K, Weiss JN. PMID: 15662034.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansAnimalsCells
    73. Genetic manipulation of cardiac Na+/Ca2+ exchange expression. Biochem Biophys Res Commun. 2004 Oct 01; 322(4):1336-40. Pott C, Goldhaber JI, Philipson KD. PMID: 15336980.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    74. Functional adult myocardium in the absence of Na+-Ca2+ exchange: cardiac-specific knockout of NCX1. Circ Res. 2004 Sep 17; 95(6):604-11. Henderson SA, Goldhaber JI, So JM, Han T, Motter C, Ngo A, Chantawansri C, Ritter MR, Friedlander M, Nicoll DA, Frank JS, Jordan MC, Roos KP, Ross RS, Philipson KD. PMID: 15308581.
      View in: PubMed   Mentions: 84     Fields:    Translation:AnimalsCells
    75. Return of calcium: manipulating intracellular calcium to prevent cardiac pathologies. Proc Natl Acad Sci U S A. 2004 Apr 20; 101(16):5697-8. Wang Y, Goldhaber JI. PMID: 15079064; PMCID: PMC395854.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    76. Mice overexpressing the cardiac sodium-calcium exchanger: defects in excitation-contraction coupling. J Physiol. 2004 Feb 01; 554(Pt 3):779-89. Reuter H, Han T, Motter C, Philipson KD, Goldhaber JI. PMID: 14645454; PMCID: PMC1664807.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    77. Cardiac excitation-contraction coupling in the absence of Na(+) - Ca2+ exchange. Cell Calcium. 2003 Jul; 34(1):19-26. Reuter H, Henderson SA, Han T, Mottino GA, Frank JS, Ross RS, Goldhaber JI, Philipson KD. PMID: 12767889.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    78. Knockout mice for pharmacological screening: testing the specificity of Na+-Ca2+ exchange inhibitors. Circ Res. 2002 Jul 26; 91(2):90-2. Reuter H, Henderson SA, Han T, Matsuda T, Baba A, Ross RS, Goldhaber JI, Philipson KD. PMID: 12142340.
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    79. The Na+-Ca2+ exchanger is essential for the action of cardiac glycosides. Circ Res. 2002 Feb 22; 90(3):305-8. Reuter H, Henderson SA, Han T, Ross RS, Goldhaber JI, Philipson KD. PMID: 11861419.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    80. Phenylarsine oxide induces mitochondrial permeability transition, hypercontracture, and cardiac cell death. Am J Physiol Heart Circ Physiol. 2001 May; 280(5):H2203-13. Korge P, Goldhaber JI, Weiss JN. PMID: 11299223.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    81. Metabolic inhibition activates a non-selective current through connexin hemichannels in isolated ventricular myocytes. J Mol Cell Cardiol. 2000 Oct; 32(10):1859-72. Kondo RP, Wang SY, John SA, Weiss JN, Goldhaber JI. PMID: 11013130.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    82. Putative ryanodine receptors in the sarcolemma of ventricular myocytes. Pflugers Arch. 2000 May; 440(1):125-31. Kondo RP, Weiss JN, Goldhaber JI. PMID: 10864005.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    83. Oxygen free radicals and excitation-contraction coupling. Antioxid Redox Signal. 2000; 2(1):55-64. Goldhaber JI, Qayyum MS. PMID: 11232601.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    84. Intracellular Ca(2+) dynamics and the stability of ventricular tachycardia. Biophys J. 1999 Dec; 77(6):2930-41. Chudin E, Goldhaber J, Garfinkel A, Weiss J, Kogan B. PMID: 10585917; PMCID: PMC1300566.
      View in: PubMed   Mentions: 121     Fields:    Translation:HumansAnimalsCells
    85. Sodium-calcium exchange: the phantom menace. Circ Res. 1999 Nov 26; 85(11):982-4. Goldhaber JI. PMID: 10571527.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    86. Local regulation of the threshold for calcium sparks in rat ventricular myocytes: role of sodium-calcium exchange. J Physiol. 1999 Oct 15; 520 Pt 2:431-8. Goldhaber JI, Lamp ST, Walter DO, Garfinkel A, Fukumoto GH, Weiss JN. PMID: 10523412; PMCID: PMC2269602.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    87. High-density lipoprotein increases intracellular calcium levels by releasing calcium from internal stores in human endothelial cells. Atherosclerosis. 1999 Apr; 143(2):299-306. Honda HM, Wakamatsu BK, Goldhaber JI, Berliner JA, Navab M, Weiss JN. PMID: 10217358.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    88. Induction of monocyte binding to endothelial cells by MM-LDL: role of lipoxygenase metabolites. Arterioscler Thromb Vasc Biol. 1999 Mar; 19(3):680-6. Honda HM, Leitinger N, Frankel M, Goldhaber JI, Natarajan R, Nadler JL, Weiss JN, Berliner JA. PMID: 10073973.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    89. Connexin-43 hemichannels opened by metabolic inhibition. J Biol Chem. 1999 Jan 01; 274(1):236-40. John SA, Kondo R, Wang SY, Goldhaber JI, Weiss JN. PMID: 9867835.
      View in: PubMed   Mentions: 117     Fields:    Translation:HumansCells
    90. Beta1 integrins participate in the hypertrophic response of rat ventricular myocytes. Circ Res. 1998 Jun 15; 82(11):1160-72. Ross RS, Pham C, Shai SY, Goldhaber JI, Fenczik C, Glembotski CC, Ginsberg MH, Loftus JC. PMID: 9633916.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    91. Safety and hemodynamic effects of intravenous triiodothyronine in advanced congestive heart failure. Am J Cardiol. 1998 Feb 15; 81(4):443-7. Hamilton MA, Stevenson LW, Fonarow GC, Steimle A, Goldhaber JI, Child JS, Chopra IJ, Moriguchi JD, Hage A. PMID: 9485134.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCTClinical Trials
    92. Localization and functional effects of adenosine A1 receptors on cardiac vagal afferents in adult rats. Am J Physiol. 1998 02; 274(2):H441-7. Middlekauff HR, Rivkees SA, Raybould HE, Bitticaca M, Goldhaber JI, Weiss JN. PMID: 9486246.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    93. Mechanism of hypoxic K loss in rabbit ventricle. J Clin Invest. 1997 Oct 01; 100(7):1782-8. Shivkumar K, Deutsch NA, Lamp ST, Khuu K, Goldhaber JI, Weiss JN. PMID: 9312178; PMCID: PMC508363.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    94. Effects of TNF-alpha on [Ca2+]i and contractility in isolated adult rabbit ventricular myocytes. Am J Physiol. 1996 Oct; 271(4 Pt 2):H1449-55. Goldhaber JI, Kim KH, Natterson PD, Lawrence T, Yang P, Weiss JN. PMID: 8897939.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    95. Free radicals enhance Na+/Ca2+ exchange in ventricular myocytes. Am J Physiol. 1996 Sep; 271(3 Pt 2):H823-33. Goldhaber JI. PMID: 8853314.
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    96. Endothelium-dependent vasodilators do not cause propagated intercellular Ca2+ waves in vascular endothelial monolayers. Cell Calcium. 1996 Feb; 19(2):97-104. Honda HM, Goldhaber JI, Demer LL, Weiss JN. PMID: 8689675.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    97. Excitation-contraction coupling in single guinea-pig ventricular myocytes exposed to hydrogen peroxide. J Physiol. 1994 May 15; 477(Pt 1):135-47. Goldhaber JI, Liu E. PMID: 8071880; PMCID: PMC1155581.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    98. Lactate transport in mammalian ventricle. General properties and relation to K+ fluxes. Circ Res. 1994 May; 74(5):829-38. Shieh RC, Goldhaber JI, Stuart JS, Weiss JN. PMID: 8156630.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    99. Effects of physical exercise training in syndrome X. Clin Cardiol. 1993 Jan; 16(1):65-6. Leaf DA, Goldhaber J. PMID: 8416764.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    100. Oxygen free radicals and cardiac reperfusion abnormalities. Hypertension. 1992 Jul; 20(1):118-27. Goldhaber JI, Weiss JN. PMID: 1618547.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimals
    101. Effects of lysophosphatidylcholine on electrophysiological properties and excitation-contraction coupling in isolated guinea pig ventricular myocytes. J Clin Invest. 1991 Dec; 88(6):1819-32. Liu E, Goldhaber JI, Weiss JN. PMID: 1721623; PMCID: PMC295749.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    102. Mechanisms of excitation-contraction coupling failure during metabolic inhibition in guinea-pig ventricular myocytes. J Physiol. 1991 Nov; 443:371-86. Goldhaber JI, Parker JM, Weiss JN. PMID: 1822531; PMCID: PMC1179846.
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    103. Effects of exogenous free radicals on electromechanical function and metabolism in isolated rabbit and guinea pig ventricle. Implications for ischemia and reperfusion injury. J Clin Invest. 1989 Jun; 83(6):1800-9. Goldhaber JI, Ji S, Lamp ST, Weiss JN. PMID: 2723059; PMCID: PMC303899.
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