Loading...

Peter Yiwen Liu

Title(s)Professor-in-Residence, Medicine
SchoolMedicine
Phone(310) 222-8184
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Mentorship in the Endocrinology of Sleep
    NIH/NHLBI K24HL138632May 1, 2018 - Apr 30, 2023
    Role: Principal Investigator
    Hormonal Mechanisms of Sleep Restriction
    NIH/NHLBI R01HL124211Aug 10, 2014 - Dec 31, 2019
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Nguyen BT, Farrant MT, Anawalt BD, Yuen F, Thirumalai A, Amory JK, Swerdloff RS, Bremner WJ, Liu PY, Blithe DL, Page ST, Wang C. Acceptability of oral dimethandrolone undecanoate in a 28-day placebo-controlled trial of a hormonal male contraceptive prototype. Contraception. 2020 Apr 13. PMID: 32298717.
      View in: PubMed
    2. Liu PY, O'Byrne NA. Adipose tissue transcriptomes in obstructive sleep apnea: location matters. Sleep. 2020 Apr 07. PMID: 32255472.
      View in: PubMed
    3. Yuen F, Thirumalai A, Pham C, Swerdloff RS, Anawalt BD, Liu PY, Amory JK, Bremner WJ, Dart C, Wu H, Hull L, Blithe DL, Long J, Wang C, Page ST. Daily Oral Administration of the Novel Androgen 11ß-MNTDC Markedly Suppresses Serum Gonadotropins in Healthy Men. J Clin Endocrinol Metab. 2020 Mar 01; 105(3). PMID: 31976519.
      View in: PubMed
    4. Roelfsema F, Liu PY, Takahashi PY, Yang RJ, Veldhuis JD. Dynamic Interactions Between LH and Testosterone in Healthy Community-Dwelling Men: Impact of Age and Body Composition. J Clin Endocrinol Metab. 2020 Mar 01; 105(3). PMID: 31790144.
      View in: PubMed
    5. Liu PY, Takahashi PY, Yang RJ, Iranmanesh A, Veldhuis JD. Age and time-of-day differences in the hypothalamo-pituitary-testicular, and adrenal, response to total overnight sleep deprivation. Sleep. 2020 Jan 29. PMID: 31993665.
      View in: PubMed
    6. Demissei BG, Hubbard RA, Zhang L, Smith AM, Sheline K, McDonald C, Narayan V, Domchek SM, DeMichele A, Shah P, Clark AS, Fox K, Matro J, Bradbury AR, Knollman H, Getz KD, Armenian SH, Januzzi JL, Tang WHW, Liu P, Ky B. Changes in Cardiovascular Biomarkers With Breast Cancer Therapy and Associations With Cardiac Dysfunction. J Am Heart Assoc. 2020 Jan 21; 9(2):e014708. PMID: 31959034.
      View in: PubMed
    7. Seimon RV, Wild-Taylor AL, Keating SE, McClintock S, Harper C, Gibson AA, Johnson NA, Fernando HA, Markovic TP, Center JR, Franklin J, Liu PY, Grieve SM, Lagopoulos J, Caterson ID, Byrne NM, Sainsbury A. Effect of Weight Loss via Severe vs Moderate Energy Restriction on Lean Mass and Body Composition Among Postmenopausal Women With Obesity: The TEMPO Diet Randomized Clinical Trial. JAMA Netw Open. 2019 Oct 02; 2(10):e1913733. PMID: 31664441.
      View in: PubMed
    8. Liu PY. A Clinical Perspective of Sleep and Andrological Health: Assessment, Treatment Considerations, and Future Research. J Clin Endocrinol Metab. 2019 Oct 01; 104(10):4398-4417. PMID: 31042277.
      View in: PubMed
    9. Wu S, Yuen F, Swerdloff RS, Pak Y, Thirumalai A, Liu PY, Amory JK, Bai F, Hull L, Blithe DL, Anawalt BD, Parman T, Kim K, Lee MS, Bremner WJ, Page ST, Wang C. Safety and Pharmacokinetics of Single-Dose Novel Oral Androgen 11ß-Methyl-19-Nortestosterone-17ß-Dodecylcarbonate in Men. J Clin Endocrinol Metab. 2019 03 01; 104(3):629-638. PMID: 30252057.
      View in: PubMed
    10. Theorell-Haglöw J, Hoyos CM, Phillips CL, Yee BJ, Melehan KL, Liu PY, Cistulli PA, Grunstein RR. Associations Between Obstructive Sleep Apnea and Measures of Arterial Stiffness. J Clin Sleep Med. 2019 02 15; 15(2):201-206. PMID: 30736873.
      View in: PubMed
    11. Thirumalai A, Ceponis J, Amory JK, Swerdloff R, Surampudi V, Liu PY, Bremner WJ, Harvey E, Blithe DL, Lee MS, Hull L, Wang C, Page ST. Effects of 28 Days of Oral Dimethandrolone Undecanoate in Healthy Men: A Prototype Male Pill. J Clin Endocrinol Metab. 2019 02 01; 104(2):423-432. PMID: 30252061.
      View in: PubMed
    12. Anania VG, Yu K, Pingitore F, Li Q, Rose CM, Liu P, Sandoval W, Herman AE, Lill JR, Mathews WR. Discovery and Qualification of Candidate Urinary Biomarkers of Disease Activity in Lupus Nephritis. J Proteome Res. 2019 03 01; 18(3):1264-1277. PMID: 30525646.
      View in: PubMed
    13. Roelfsema F, Yang RJ, Liu PY, Takahashi PY, Veldhuis JD. Feedback on LH in Testosterone-Clamped Men Depends on the Mode of Testosterone Administration and Body Composition. J Endocr Soc. 2019 Jan 01; 3(1):235-249. PMID: 30623162.
      View in: PubMed
    14. Hoyos CM, Murugan SM, Melehan KL, Yee BJ, Phillips CL, Killick R, Cayanan EA, Wong KK, Liu PY, Grunstein RR, Marshall NS. Dose-dependent effects of continuous positive airway pressure for sleep apnea on weight or metabolic function: Individual patient-level clinical trial meta-analysis. J Sleep Res. 2019 Oct; 28(5):e12788. PMID: 30450787.
      View in: PubMed
    15. Demissei BG, Freedman G, Feigenberg SJ, Plastaras JP, Maity A, Smith AM, McDonald C, Sheline K, Simone CB, Lin LL, Carver JR, Liu P, Zhang L, Bekelman JE, Ky B. Early Changes in Cardiovascular Biomarkers with Contemporary Thoracic Radiation Therapy for Breast Cancer, Lung Cancer, and Lymphoma. Int J Radiat Oncol Biol Phys. 2019 03 15; 103(4):851-860. PMID: 30445173.
      View in: PubMed
    16. Friedman DJ, Liu P, Barnett AS, Campbell KB, Jackson KP, Bahnson TD, Daubert JP, Piccini JP. Obstructive sleep apnea is associated with increased rotor burden in patients undergoing focal impulse and rotor modification guided atrial fibrillation ablation. Europace. 2018 11 01; 20(FI_3):f337-f342. PMID: 29016785.
      View in: PubMed
    17. Zhang W, Piotrowska K, Chavoshan B, Wallace J, Liu PY. Sleep Duration Is Associated With Testis Size in Healthy Young Men. J Clin Sleep Med. 2018 10 15; 14(10):1757-1764. PMID: 30353813.
      View in: PubMed
    18. Melehan KL, Hoyos CM, Hamilton GS, Wong KK, Yee BJ, McLachlan RI, O'Meagher S, Celermajer D, Ng MK, Grunstein RR, Liu PY. Randomized Trial of CPAP and Vardenafil on Erectile and Arterial Function in Men With Obstructive Sleep Apnea and Erectile Dysfunction. J Clin Endocrinol Metab. 2018 04 01; 103(4):1601-1611. PMID: 29409064.
      View in: PubMed
    19. Yee JK, Lucas-Wright A, Liu PY, Chung B, Bross R, Malkhassian S, Norris KC, Wang C, Jones L. Initiating Dialogue in Community-Partnered Participatory Research to Address Obesity in South Los Angeles. J Health Care Poor Underserved. 2018; 29(2):601-614. PMID: 29805126.
      View in: PubMed
    20. Theorell-Haglöw J, Hoyos CM, Phillips CL, Yee BJ, Herrmann M, Brennan-Speranza TC, Grunstein RR, Liu PY. Changes of vitamin D levels and bone turnover markers after CPAP therapy: a randomized sham-controlled trial. J Sleep Res. 2018 08; 27(4):e12606. PMID: 28944524.
      View in: PubMed
    21. Jia Y, Yee JK, Wang C, Nikolaenko L, Diaz-Arjonilla M, Cohen JN, French SW, Liu PY, Lue Y, Lee WP, Swerdloff RS. Testosterone protects high-fat/low-carbohydrate diet-induced nonalcoholic fatty liver disease in castrated male rats mainly via modulating endoplasmic reticulum stress. Am J Physiol Endocrinol Metab. 2018 04 01; 314(4):E366-E376. PMID: 28928235.
      View in: PubMed
    22. Liu PY. Assessing new peptides that may be involved in the physiological regulation of the gonadal axis in humans: gonadotrophin inhibitory hormone. Clin Endocrinol (Oxf). 2017 05; 86(5):658-659. PMID: 28295469.
      View in: PubMed
    23. Tu JV, Maclagan LC, Ko DT, Atzema CL, Booth GL, Johnston S, Tu K, Lee DS, Bierman A, Hall R, Bhatia RS, Gershon AS, Tobe SW, Sanmartin C, Liu P, Chu A. The Cardiovascular Health in Ambulatory Care Research Team performance indicators for the primary prevention of cardiovascular disease: a modified Delphi panel study. CMAJ Open. 2017 Apr 25; 5(2):E315-E321. PMID: 28446446.
      View in: PubMed
    24. Gandhi PU, Gaggin HK, Redfield MM, Chen HH, Stevens SR, Anstrom KJ, Semigran MJ, Liu P, Januzzi JL. Insulin-Like Growth Factor-Binding Protein-7 as a Biomarker of Diastolic Dysfunction and Functional Capacity in Heart Failure With Preserved Ejection Fraction: Results From the RELAX Trial. JACC Heart Fail. 2016 11; 4(11):860-869. PMID: 27744089.
      View in: PubMed
    25. Piotrowska K, Wang C, Swerdloff RS, Liu PY. Male hormonal contraception: hope and promise. Lancet Diabetes Endocrinol. 2017 03; 5(3):214-223. PMID: 26915313.
      View in: PubMed
    26. Hoyos CM, Yee BJ, Phillips CL, Machan EA, Grunstein RR, Liu PY. Body compositional and cardiometabolic effects of testosterone therapy in obese men with severe obstructive sleep apnea: a randomized placebo-controlled trial. Eur J Endocrinol. 2015 Nov; 173(5):X3. PMID: 26516206.
      View in: PubMed
    27. Swerdloff RS, Pak Y, Wang C, Liu PY, Bhasin S, Gill TM, Matsumoto AM, Pahor M, Surampudi P, Snyder PJ. Serum Testosterone (T) Level Variability in T Gel-Treated Older Hypogonadal Men: Treatment Monitoring Implications. J Clin Endocrinol Metab. 2015 Sep; 100(9):3280-7. PMID: 26120790.
      View in: PubMed
    28. Jia Y, Ohanyan A, Lue YH, Swerdloff RS, Liu PY, Cohen P, Wang C. The effects of humanin and its analogues on male germ cell apoptosis induced by chemotherapeutic drugs. Apoptosis. 2015 Apr; 20(4):551-61. PMID: 25666707.
      View in: PubMed
    29. Killick R, Hoyos CM, Melehan KL, Dungan GC, Poh J, Liu PY. Metabolic and hormonal effects of 'catch-up' sleep in men with chronic, repetitive, lifestyle-driven sleep restriction. Clin Endocrinol (Oxf). 2015 Oct; 83(4):498-507. PMID: 25683266.
      View in: PubMed
    30. D'Rozario AL, Dungan GC, Banks S, Liu PY, Wong KK, Killick R, Grunstein RR, Kim JW. An automated algorithm to identify and reject artefacts for quantitative EEG analysis during sleep in patients with sleep-disordered breathing. Sleep Breath. 2015 May; 19(2):607-15. PMID: 25225154.
      View in: PubMed
    31. Hoyos CM, Melehan KL, Liu PY, Grunstein RR, Phillips CL. Does obstructive sleep apnea cause endothelial dysfunction? A critical review of the literature. Sleep Med Rev. 2015 Apr; 20:15-26. PMID: 25088969.
      View in: PubMed
    32. Surampudi P, Page ST, Swerdloff RS, Nya-Ngatchou JJ, Liu PY, Amory JK, Leung A, Hull L, Blithe DL, Woo J, Bremner WJ, Wang C. Single, escalating dose pharmacokinetics, safety and food effects of a new oral androgen dimethandrolone undecanoate in man: a prototype oral male hormonal contraceptive. Andrology. 2014 Jul; 2(4):579-587. PMID: 24789057.
      View in: PubMed
    33. Hoyos CM, Killick R, Keenan DM, Baxter RC, Veldhuis JD, Liu PY. Continuous positive airway pressure increases pulsatile growth hormone secretion and circulating insulin-like growth factor-1 in a time-dependent manner in men with obstructive sleep apnea: a randomized sham-controlled study. Sleep. 2014 Apr 01; 37(4):733-41. PMID: 24899762.
      View in: PubMed
    34. Hoyos CM, Melehan KL, Phillips CL, Grunstein RR, Liu PY. To ED or not to ED--is erectile dysfunction in obstructive sleep apnea related to endothelial dysfunction? Sleep Med Rev. 2015 Apr; 20:5-14. PMID: 24813467.
      View in: PubMed
    35. Myerburg RJ, Halperin H, Egan DA, Boineau R, Chugh SS, Gillis AM, Goldhaber JI, Lathrop DA, Liu P, Niemann JT, Ornato JP, Sopko G, Van Eyk JE, Walcott GP, Weisfeldt ML, Wright JD, Zipes DP. Pulseless electric activity: definition, causes, mechanisms, management, and research priorities for the next decade: report from a National Heart, Lung, and Blood Institute workshop. Circulation. 2013 Dec 03; 128(23):2532-41. PMID: 24297818.
      View in: PubMed
    36. Simpson PJ, Hoyos CM, Celermajer D, Liu PY, Ng MK. Effects of continuous positive airway pressure on endothelial function and circulating progenitor cells in obstructive sleep apnoea: a randomised sham-controlled study. Int J Cardiol. 2013 Oct 03; 168(3):2042-8. PMID: 23453448.
      View in: PubMed
    37. Killick R, Wang D, Hoyos CM, Yee BJ, Grunstein RR, Liu PY. The effects of testosterone on ventilatory responses in men with obstructive sleep apnea: a randomised, placebo-controlled trial. J Sleep Res. 2013 Jun; 22(3):331-6. PMID: 23331844.
      View in: PubMed
    38. Wang S, McKenna M, Wei Z, Liu J, Liu P, Summers RM. Visual phrase learning and its application in computed tomographic colonography. Med Image Comput Comput Assist Interv. 2013; 16(Pt 1):243-50. PMID: 24505672.
      View in: PubMed
    39. Hoyos CM, Killick R, Yee BJ, Grunstein RR, Liu PY. Effects of testosterone therapy on sleep and breathing in obese men with severe obstructive sleep apnoea: a randomized placebo-controlled trial. Clin Endocrinol (Oxf). 2012 Oct; 77(4):599-607. PMID: 22512435.
      View in: PubMed
    40. Killick R, Banks S, Liu PY. Implications of sleep restriction and recovery on metabolic outcomes. J Clin Endocrinol Metab. 2012 Nov; 97(11):3876-90. PMID: 22996147.
      View in: PubMed
    41. Veldhuis JD, Liu PY, Takahashi PY, Weist SM, Wigham JR. Analysis of the impact of intravenous LH pulses versus continuous LH infusion on testosterone secretion during GnRH-receptor blockade. Am J Physiol Regul Integr Comp Physiol. 2012 Nov 15; 303(10):R994-R1002. PMID: 22992702.
      View in: PubMed
    42. Brillante R, Laks L, Cossa G, Peters M, Liu P. An overnight increase in CO2 predicts mortality in sleep disordered breathing. Respirology. 2012 Aug; 17(6):933-9. PMID: 22671994.
      View in: PubMed
    43. Hoyos CM, Yee BJ, Phillips CL, Machan EA, Grunstein RR, Liu PY. Body compositional and cardiometabolic effects of testosterone therapy in obese men with severe obstructive sleep apnoea: a randomised placebo-controlled trial. Eur J Endocrinol. 2012 Oct; 167(4):531-41. PMID: 22848006.
      View in: PubMed
    44. Reynolds AC, Dorrian J, Liu PY, Van Dongen HP, Wittert GA, Harmer LJ, Banks S. Impact of five nights of sleep restriction on glucose metabolism, leptin and testosterone in young adult men. PLoS One. 2012; 7(7):e41218. PMID: 22844441.
      View in: PubMed
    45. Veldhuis JD, Liu PY, Takahashi PY, Keenan DM. Dynamic testosterone responses to near-physiological LH pulses are determined by the time pattern of prior intravenous LH infusion. Am J Physiol Endocrinol Metab. 2012 Sep 15; 303(6):E720-8. PMID: 22811471.
      View in: PubMed
    46. Hoyos CM, Killick R, Yee BJ, Phillips CL, Grunstein RR, Liu PY. Cardiometabolic changes after continuous positive airway pressure for obstructive sleep apnoea: a randomised sham-controlled study. Thorax. 2012 Dec; 67(12):1081-9. PMID: 22561530.
      View in: PubMed
    47. Brillante R, Cossa G, Liu PY, Laks L. Rapid eye movement and slow-wave sleep rebound after one night of continuous positive airway pressure for obstructive sleep apnoea. Respirology. 2012 Apr; 17(3):547-53. PMID: 22309157.
      View in: PubMed
    48. Sivam S, Phillips CL, Trenell MI, Yee BJ, Liu PY, Wong KK, Grunstein RR. Effects of 8 weeks of continuous positive airway pressure on abdominal adiposity in obstructive sleep apnoea. Eur Respir J. 2012 Oct; 40(4):913-8. PMID: 22267762.
      View in: PubMed
    49. Wang S, Liu P, Turkbey B, Choyke P, Pinto P, Summers RM. Gaussian process inference for estimating pharmacokinetic parameters of dynamic contrast-enhanced MR images. Med Image Comput Comput Assist Interv. 2012; 15(Pt 3):582-9. PMID: 23286178.
      View in: PubMed
    50. Veldhuis JD, Liu PY, Keenan DM, Takahashi PY. Older men exhibit reduced efficacy of and heightened potency downregulation by intravenous pulses of recombinant human LH: a study in 92 healthy men. Am J Physiol Endocrinol Metab. 2012 Jan 01; 302(1):E117-22. PMID: 21971523.
      View in: PubMed
    51. Wang X, Keenan DM, Pincus SM, Liu PY, Veldhuis JD. Oscillations in joint synchrony of reproductive hormones in healthy men. Am J Physiol Endocrinol Metab. 2011 Dec; 301(6):E1163-73. PMID: 21900124.
      View in: PubMed
    52. Marshall NS, Wong KK, Liu PY, Grunstein RR. Smoking is not better for you than sleep apnea. J Clin Sleep Med. 2011 Jun 15; 7(3):317. PMID: 21677906.
      View in: PubMed
    53. Phillips CL, Yee BJ, Marshall NS, Liu PY, Sullivan DR, Grunstein RR. Continuous positive airway pressure reduces postprandial lipidemia in obstructive sleep apnea: a randomized, placebo-controlled crossover trial. Am J Respir Crit Care Med. 2011 Aug 01; 184(3):355-61. PMID: 21527567.
      View in: PubMed
    54. Ilani N, Liu PY, Swerdloff RS, Wang C. Does ethnicity matter in male hormonal contraceptive efficacy? Asian J Androl. 2011 Jul; 13(4):579-84. PMID: 21317912.
      View in: PubMed
    55. Swerdloff RS, Lue Y, Liu PY, Erkkilä K, Wang C. Mouse model for men with klinefelter syndrome: a multifaceted fit for a complex disorder. Acta Paediatr. 2011 Jun; 100(6):892-9. PMID: 21226760.
      View in: PubMed
    56. Lue YH, Wang C, Liu PY, Erkilla K, Swerdloff RS. Insights into the pathogenesis of XXY phenotype from comparison of the clinical syndrome with an experimental XXY mouse model. Pediatr Endocrinol Rev. 2010 Dec; 8 Suppl 1:140-4. PMID: 21217605.
      View in: PubMed
    57. Bousette N, Chugh S, Fong V, Isserlin R, Kim KH, Volchuk A, Backx PH, Liu P, Kislinger T, MacLennan DH, Emili A, Gramolini AO. Constitutively active calcineurin induces cardiac endoplasmic reticulum stress and protects against apoptosis that is mediated by alpha-crystallin-B. Proc Natl Acad Sci U S A. 2010 Oct 26; 107(43):18481-6. PMID: 20937869.
      View in: PubMed
    58. Liu PY, Kalak R, Lue Y, Jia Y, Erkkila K, Zhou H, Seibel MJ, Wang C, Swerdloff RS, Dunstan CR. Genetic and hormonal control of bone volume, architecture, and remodeling in XXY mice. J Bone Miner Res. 2010 Oct; 25(10):2148-54. PMID: 20499350.
      View in: PubMed
    59. Veldhuis JD, Takahashi PY, Keenan DM, Liu PY, Mielke KL, Weist SM. Age disrupts androgen receptor-modulated negative feedback in the gonadal axis in healthy men. Am J Physiol Endocrinol Metab. 2010 Oct; 299(4):E675-82. PMID: 20682842.
      View in: PubMed
    60. Liu PY, Erkkila K, Lue Y, Jentsch JD, Schwarcz MD, Abuyounes D, Hikim AS, Wang C, Lee PW, Swerdloff RS. Genetic, hormonal, and metabolomic influences on social behavior and sex preference of XXY mice. Am J Physiol Endocrinol Metab. 2010 Sep; 299(3):E446-55. PMID: 20570823.
      View in: PubMed
    61. Liu PY, Swerdloff RS, Wang C. Recent methodological advances in male hormonal contraception. Contraception. 2010 Nov; 82(5):471-5. PMID: 20933121.
      View in: PubMed
    62. Veldhuis JD, Keenan DM, Liu PY, Takahashi PY. Kinetics of removal of intravenous testosterone pulses in normal men. Eur J Endocrinol. 2010 Apr; 162(4):787-94. PMID: 20089549.
      View in: PubMed
    63. Williams SC, Marshall NS, Kennerson M, Rogers NL, Liu PY, Grunstein RR. Modafinil effects during acute continuous positive airway pressure withdrawal: a randomized crossover double-blind placebo-controlled trial. Am J Respir Crit Care Med. 2010 Apr 15; 181(8):825-31. PMID: 20056901.
      View in: PubMed
    64. Cooper LT, Onuma OK, Sagar S, Oberg AL, Mahoney DW, Asmann YW, Liu P. Genomic and proteomic analysis of myocarditis and dilated cardiomyopathy. Heart Fail Clin. 2010 Jan; 6(1):75-85. PMID: 19945063.
      View in: PubMed
    65. Metra M, Eichhorn E, Abraham WT, Linseman J, Böhm M, Corbalan R, DeMets D, De Marco T, Elkayam U, Gerber M, Komajda M, Liu P, Mareev V, Perrone SV, Poole-Wilson P, Roecker E, Stewart J, Swedberg K, Tendera M, Wiens B, Bristow MR. Effects of low-dose oral enoximone administration on mortality, morbidity, and exercise capacity in patients with advanced heart failure: the randomized, double-blind, placebo-controlled, parallel group ESSENTIAL trials. Eur Heart J. 2009 Dec; 30(24):3015-26. PMID: 19700774.
      View in: PubMed
    66. Ip FF, di Pierro I, Brown R, Cunningham I, Handelsman DJ, Liu PY. Trough serum testosterone predicts the development of polycythemia in hypogonadal men treated for up to 21 years with subcutaneous testosterone pellets. Eur J Endocrinol. 2010 Feb; 162(2):385-90. PMID: 19903801.
      View in: PubMed
    67. Fennell C, Sartorius G, Ly LP, Turner L, Liu PY, Conway AJ, Handelsman DJ. Randomized cross-over clinical trial of injectable vs. implantable depot testosterone for maintenance of testosterone replacement therapy in androgen deficient men. Clin Endocrinol (Oxf). 2010 Jul; 73(1):102-9. PMID: 19891698.
      View in: PubMed
    68. Liu PY, Takahashi PY, Roebuck PD, Bailey JN, Keenan DM, Veldhuis JD. Testosterone's short-term positive effect on luteinizing-hormone secretory-burst mass and its negative effect on secretory-burst frequency are attenuated in middle-aged men. J Clin Endocrinol Metab. 2009 Oct; 94(10):3978-86. PMID: 19584190.
      View in: PubMed
    69. Liu PY, Keenan DM, Kok P, Padmanabhan V, O'Byrne KT, Veldhuis JD. Sensitivity and specificity of pulse detection using a new deconvolution method. Am J Physiol Endocrinol Metab. 2009 Aug; 297(2):E538-44. PMID: 19531646.
      View in: PubMed
    70. Bunda S, Wang Y, Mitts TF, Liu P, Arab S, Arabkhari M, Hinek A. Aldosterone stimulates elastogenesis in cardiac fibroblasts via mineralocorticoid receptor-independent action involving the consecutive activation of Galpha13, c-Src, the insulin-like growth factor-I receptor, and phosphatidylinositol 3-kinase/Akt. J Biol Chem. 2009 Jun 12; 284(24):16633-47. PMID: 19372600.
      View in: PubMed
    71. Kalak R, Zhou H, Street J, Day RE, Modzelewski JR, Spies CM, Liu PY, Li G, Dunstan CR, Seibel MJ. Endogenous glucocorticoid signalling in osteoblasts is necessary to maintain normal bone structure in mice. Bone. 2009 Jul; 45(1):61-7. PMID: 19358901.
      View in: PubMed
    72. Marshall NS, Wong KK, Phillips CL, Liu PY, Knuiman MW, Grunstein RR. Is sleep apnea an independent risk factor for prevalent and incident diabetes in the Busselton Health Study? J Clin Sleep Med. 2009 Feb 15; 5(1):15-20. PMID: 19317376.
      View in: PubMed
    73. Liu PY, Baker HW, Jayadev V, Zacharin M, Conway AJ, Handelsman DJ. Induction of spermatogenesis and fertility during gonadotropin treatment of gonadotropin-deficient infertile men: predictors of fertility outcome. J Clin Endocrinol Metab. 2009 Mar; 94(3):801-8. PMID: 19066302.
      View in: PubMed
    74. Veldhuis JD, Keenan DM, Liu PY, Iranmanesh A, Takahashi PY, Nehra AX. The aging male hypothalamic-pituitary-gonadal axis: pulsatility and feedback. Mol Cell Endocrinol. 2009 Feb 05; 299(1):14-22. PMID: 18838102.
      View in: PubMed
    75. Marshall NS, Wong KK, Liu PY, Cullen SR, Knuiman MW, Grunstein RR. Sleep apnea as an independent risk factor for all-cause mortality: the Busselton Health Study. Sleep. 2008 Aug; 31(8):1079-85. PMID: 18714779.
      View in: PubMed
    76. Liu PY, McLachlan RI. Male hormonal contraception: so near and yet so far. J Clin Endocrinol Metab. 2008 Jul; 93(7):2474-6. PMID: 18617702.
      View in: PubMed
    77. Liu PY, Swerdloff RS, Anawalt BD, Anderson RA, Bremner WJ, Elliesen J, Gu YQ, Kersemaekers WM, McLachlan RI, Meriggiola MC, Nieschlag E, Sitruk-Ware R, Vogelsong K, Wang XH, Wu FC, Zitzmann M, Handelsman DJ, Wang C. Determinants of the rate and extent of spermatogenic suppression during hormonal male contraception: an integrated analysis. J Clin Endocrinol Metab. 2008 May; 93(5):1774-83. PMID: 18303073.
      View in: PubMed
    78. Grunstein RR, Phillips CL, Liu PY. Sleep apnea--past, present, future. Sleep Med Rev. 2008 Feb; 12(1):1-4. PMID: 18201661.
      View in: PubMed
    79. Yee BJ, Buchanan PR, Mahadev S, Banerjee D, Liu PY, Phillips C, Loughnan G, Steinbeck K, Grunstein RR. Assessment of sleep and breathing in adults with prader-willi syndrome: a case control series. J Clin Sleep Med. 2007 Dec 15; 3(7):713-8. PMID: 18198805.
      View in: PubMed
    80. Liu PY, Iranmanesh A, Keenan DM, Pincus SM, Veldhuis JD. A noninvasive measure of negative-feedback strength, approximate entropy, unmasks strong diurnal variations in the regularity of LH secretion. Am J Physiol Endocrinol Metab. 2007 Nov; 293(5):E1409-15. PMID: 17848633.
      View in: PubMed
    81. Bunda S, Liu P, Wang Y, Liu K, Hinek A. Aldosterone induces elastin production in cardiac fibroblasts through activation of insulin-like growth factor-I receptors in a mineralocorticoid receptor-independent manner. Am J Pathol. 2007 Sep; 171(3):809-19. PMID: 17724138.
      View in: PubMed
    82. Liu PY, Beilin J, Meier C, Nguyen TV, Center JR, Leedman PJ, Seibel MJ, Eisman JA, Handelsman DJ. Age-related changes in serum testosterone and sex hormone binding globulin in Australian men: longitudinal analyses of two geographically separate regional cohorts. J Clin Endocrinol Metab. 2007 Sep; 92(9):3599-603. PMID: 17595245.
      View in: PubMed
    83. Liu PY, Caterson ID, Grunstein RR, Handelsman DJ. Androgens, obesity, and sleep-disordered breathing in men. Endocrinol Metab Clin North Am. 2007 Jun; 36(2):349-63. PMID: 17543723.
      View in: PubMed
    84. Lue Y, Erkkila K, Liu PY, Ma K, Wang C, Hikim AS, Swerdloff RS. Fate of bone marrow stem cells transplanted into the testis: potential implication for men with testicular failure. Am J Pathol. 2007 Mar; 170(3):899-908. PMID: 17322375.
      View in: PubMed
    85. Liu PY, Handelsman DJ. Early markers of metabolic syndrome in nonoverweight, middle-aged men. Nat Clin Pract Urol. 2006 Oct; 3(10):524-5. PMID: 17031374.
      View in: PubMed
    86. Liu PY, Takahashi PY, Roebuck PD, Veldhuis JD. Age or factors associated with aging attenuate testosterone's concentration-dependent enhancement of the regularity of luteinizing hormone secretion in healthy men. J Clin Endocrinol Metab. 2006 Oct; 91(10):4077-84. PMID: 16868060.
      View in: PubMed
    87. Liu PY, Swerdloff RS, Christenson PD, Handelsman DJ, Wang C. Rate, extent, and modifiers of spermatogenic recovery after hormonal male contraception: an integrated analysis. Lancet. 2006 Apr 29; 367(9520):1412-20. PMID: 16650651.
      View in: PubMed
    88. Christian RC, Liu PY, Harrington S, Ruan M, Miller VM, Fitzpatrick LA. Intimal estrogen receptor (ER)beta, but not ERalpha expression, is correlated with coronary calcification and atherosclerosis in pre- and postmenopausal women. J Clin Endocrinol Metab. 2006 Jul; 91(7):2713-20. PMID: 16608893.
      View in: PubMed
    89. Handelsman DJ, Liu PY. Klinefelter's syndrome--a microcosm of male reproductive health. J Clin Endocrinol Metab. 2006 Apr; 91(4):1220-2. PMID: 16601196.
      View in: PubMed
    90. Keenan DM, Takahashi PY, Liu PY, Roebuck PD, Nehra AX, Iranmanesh A, Veldhuis JD. An ensemble model of the male gonadal axis: illustrative application in aging men. Endocrinology. 2006 Jun; 147(6):2817-28. PMID: 16513832.
      View in: PubMed
    91. Liu PY, Wang C, Swerdloff RS. Does individual response to androgen replacement therapy affect bone density? Nat Clin Pract Endocrinol Metab. 2006 Feb; 2(2):76-7. PMID: 16932260.
      View in: PubMed
    92. Liu PY, Pincus SM, Takahashi PY, Roebuck PD, Iranmanesh A, Keenan DM, Veldhuis JD. Aging attenuates both the regularity and joint synchrony of LH and testosterone secretion in normal men: analyses via a model of graded GnRH receptor blockade. Am J Physiol Endocrinol Metab. 2006 Jan; 290(1):E34-E41. PMID: 16339924.
      View in: PubMed
    93. Meier C, Liu PY, Handelsman DJ, Seibel MJ. Endocrine regulation of bone turnover in men. Clin Endocrinol (Oxf). 2005 Dec; 63(6):603-16. PMID: 16343093.
      View in: PubMed
    94. Liu PY, Iranmanesh A, Nehra AX, Keenan DM, Veldhuis JD. Mechanisms of hypoandrogenemia in healthy aging men. Endocrinol Metab Clin North Am. 2005 Dec; 34(4):935-55, ix. PMID: 16310632.
      View in: PubMed
    95. Liu PY, Wang C, Swerdloff RS. Male sex matters. Clin Endocrinol (Oxf). 2005 Dec; 63(6):601-2. PMID: 16343092.
      View in: PubMed
    96. Liu PY, Swerdloff RS, Wang C. Relative testosterone deficiency in older men: clinical definition and presentation. Endocrinol Metab Clin North Am. 2005 Dec; 34(4):957-72, x. PMID: 16310633.
      View in: PubMed
    97. Thieben MJ, Blacker DJ, Liu PY, Harper CM, Wijdicks EF. Pulmonary function tests and blood gases in worsening myasthenia gravis. Muscle Nerve. 2005 Nov; 32(5):664-7. PMID: 16025526.
      View in: PubMed
    98. Liu PY, Takahashi PY, Roebuck PD, Iranmanesh A, Veldhuis JD. Aging in healthy men impairs recombinant human luteinizing hormone (LH)-stimulated testosterone secretion monitored under a two-day intravenous pulsatile LH clamp. J Clin Endocrinol Metab. 2005 Oct; 90(10):5544-50. PMID: 16030163.
      View in: PubMed
    99. Liu PY, Takahashi PY, Roebuck PD, Iranmanesh A, Veldhuis JD. Age-specific changes in the regulation of LH-dependent testosterone secretion: assessing responsiveness to varying endogenous gonadotropin output in normal men. Am J Physiol Regul Integr Comp Physiol. 2005 Sep; 289(3):R721-8. PMID: 15890794.
      View in: PubMed
    100. Ly LP, Liu PY, Handelsman DJ. Rates of suppression and recovery of human sperm output in testosterone-based hormonal contraceptive regimens. Hum Reprod. 2005 Jun; 20(6):1733-40. PMID: 15860500.
      View in: PubMed
    101. Handelsman DJ, Liu PY. Andropause: invention, prevention, rejuvenation. Trends Endocrinol Metab. 2005 Mar; 16(2):39-45. PMID: 15734143.
      View in: PubMed
    102. Takahashi PY, Liu PY, Roebuck PD, Iranmanesh A, Veldhuis JD. Graded inhibition of pulsatile luteinizing hormone secretion by a selective gonadotropin-releasing hormone (GnRH)-receptor antagonist in healthy men: evidence that age attenuates hypothalamic GnRH outflow. J Clin Endocrinol Metab. 2005 May; 90(5):2768-74. PMID: 15741251.
      View in: PubMed
    103. Liu PY, Pincus SM, Keenan DM, Roelfsema F, Veldhuis JD. Joint synchrony of reciprocal hormonal signaling in human paradigms of both ACTH excess and cortisol depletion. Am J Physiol Endocrinol Metab. 2005 Jul; 289(1):E160-5. PMID: 15727954.
      View in: PubMed
    104. Liu PY, Hoey KA, Mielke KL, Veldhuis JD, Khosla S. A randomized placebo-controlled trial of short-term graded transdermal estradiol in healthy gonadotropin-releasing hormone agonist-suppressed pre- and postmenopausal women: effects on serum markers of bone turnover, insulin-like growth factor-I, and osteoclastogenic mediators. J Clin Endocrinol Metab. 2005 Apr; 90(4):1953-60. PMID: 15623811.
      View in: PubMed
    105. Vonder Muhll I, Liu P, Webb G. Applying standard therapies to new targets: the use of ACE inhibitors and B-blockers for heart failure in adults with congenital heart disease. Int J Cardiol. 2004 Dec; 97 Suppl 1:25-33. PMID: 15590076.
      View in: PubMed
    106. Liu PY, Christian RC, Ruan M, Miller VM, Fitzpatrick LA. Correlating androgen and estrogen steroid receptor expression with coronary calcification and atherosclerosis in men without known coronary artery disease. J Clin Endocrinol Metab. 2005 Feb; 90(2):1041-6. PMID: 15536156.
      View in: PubMed
    107. Yee B, Liu P, Phillips C, Grunstein R. Neuroendocrine changes in sleep apnea. Curr Opin Pulm Med. 2004 Nov; 10(6):475-81. PMID: 15510053.
      View in: PubMed
    108. Liu PY, Pincus SM, Keenan DM, Roelfsema F, Veldhuis JD. Analysis of bidirectional pattern synchrony of concentration-secretion pairs: implementation in the human testicular and adrenal axes. Am J Physiol Regul Integr Comp Physiol. 2005 Feb; 288(2):R440-6. PMID: 15486096.
      View in: PubMed
    109. Liu PY, Swerdloff RS, Veldhuis JD. Clinical review 171: The rationale, efficacy and safety of androgen therapy in older men: future research and current practice recommendations. J Clin Endocrinol Metab. 2004 Oct; 89(10):4789-96. PMID: 15472164.
      View in: PubMed
    110. Nian M, Lee P, Khaper N, Liu P. Inflammatory cytokines and postmyocardial infarction remodeling. Circ Res. 2004 Jun 25; 94(12):1543-53. PMID: 15217919.
      View in: PubMed
    111. Miller VM, Tindall DJ, Liu PY. Of mice, men, and hormones. Arterioscler Thromb Vasc Biol. 2004 Jun; 24(6):995-7. PMID: 15178572.
      View in: PubMed
    112. Meier C, Liu PY, Ly LP, de Winter-Modzelewski J, Jimenez M, Handelsman DJ, Seibel MJ. Recombinant human chorionic gonadotropin but not dihydrotestosterone alone stimulates osteoblastic collagen synthesis in older men with partial age-related androgen deficiency. J Clin Endocrinol Metab. 2004 Jun; 89(6):3033-41. PMID: 15181095.
      View in: PubMed
    113. Turner L, Conway AJ, Jimenez M, Liu PY, Forbes E, McLachlan RI, Handelsman DJ. Contraceptive efficacy of a depot progestin and androgen combination in men. J Clin Endocrinol Metab. 2003 Oct; 88(10):4659-67. PMID: 14557437.
      View in: PubMed
    114. Liu PY, Yee B, Wishart SM, Jimenez M, Jung DG, Grunstein RR, Handelsman DJ. The short-term effects of high-dose testosterone on sleep, breathing, and function in older men. J Clin Endocrinol Metab. 2003 Aug; 88(8):3605-13. PMID: 12915643.
      View in: PubMed
    115. Crawford BA, Liu PY, Kean MT, Bleasel JF, Handelsman DJ. Randomized placebo-controlled trial of androgen effects on muscle and bone in men requiring long-term systemic glucocorticoid treatment. J Clin Endocrinol Metab. 2003 Jul; 88(7):3167-76. PMID: 12843161.
      View in: PubMed
    116. Liu PY, Death AK, Handelsman DJ. Androgens and cardiovascular disease. Endocr Rev. 2003 Jun; 24(3):313-40. PMID: 12788802.
      View in: PubMed
    117. Bentkover JD, Stewart EJ, Ignaszewski A, Lepage S, Liu P, Cooper J. New technologies and potential cost savings related to morbidity and mortality reduction in Class III/IV heart failure patients in Canada. Int J Cardiol. 2003 Mar; 88(1):33-41. PMID: 12659982.
      View in: PubMed
    118. Liu PY, Wishart SM, Celermajer DS, Jimenez M, Pierro ID, Conway AJ, Handelsman DJ. Do reproductive hormones modify insulin sensitivity and metabolism in older men? A randomized, placebo-controlled clinical trial of recombinant human chorionic gonadotropin. Eur J Endocrinol. 2003 Jan; 148(1):55-66. PMID: 12534358.
      View in: PubMed
    119. Liu PY, Handelsman DJ. The present and future state of hormonal treatment for male infertility. Hum Reprod Update. 2003 Jan-Feb; 9(1):9-23. PMID: 12638778.
      View in: PubMed
    120. Fredriksen PM, Therrien J, Veldtman G, Ali Warsi M, Liu P, Thaulow E, Webb G. Aerobic capacity in adults with tetralogy of Fallot. Cardiol Young. 2002 Dec; 12(6):554-9. PMID: 12636004.
      View in: PubMed
    121. Liu PY, Wishart SM, Handelsman DJ. A double-blind, placebo-controlled, randomized clinical trial of recombinant human chorionic gonadotropin on muscle strength and physical function and activity in older men with partial age-related androgen deficiency. J Clin Endocrinol Metab. 2002 Jul; 87(7):3125-35. PMID: 12107212.
      View in: PubMed
    122. Ng MK, Liu PY, Williams AJ, Nakhla S, Ly LP, Handelsman DJ, Celermajer DS. Prospective study of effect of androgens on serum inflammatory markers in men. Arterioscler Thromb Vasc Biol. 2002 Jul 01; 22(7):1136-41. PMID: 12117728.
      View in: PubMed
    123. Liu PY, Gebski VJ, Turner L, Conway AJ, Wishart SM, Handelsman DJ. Predicting pregnancy and spermatogenesis by survival analysis during gonadotrophin treatment of gonadotrophin-deficient infertile men. Hum Reprod. 2002 Mar; 17(3):625-33. PMID: 11870114.
      View in: PubMed