Michael Ray Irwin

Title(s)Professor-in-Residence, Psychiatry and Biobehavioral Sciences
SchoolMedicine
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    Dr. Michael R. Irwin holds the Norman Cousins Endowed Chair in Psychoneuroimmunology.

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    Mindfulness Meditation and Insomnia in Alzheimer Disease Caregivers: Inflammatory and Biological Aging Mechanisms
    NIH R01AG056424Sep 1, 2017 - Jun 30, 2022
    Role: Principal Investigator
    Biobehavioral Effects of Qigong for Prostate Cancer Survivors with Fatigue
    NIH R01CA203930Dec 9, 2016 - Nov 30, 2021
    Role: Co-Principal Investigator
    Experimental Model of Depression in Aging: Insomnia, Inflammation, and Affect Mechanisms
    NIH R01AG051944Sep 15, 2016 - Apr 30, 2021
    Role: Principal Investigator
    Sleep Disturbance, Inflammation, and Cellular Aging in Breast Cancer Survivors
    NIH R01CA207130Jul 1, 2016 - Jun 30, 2021
    Role: Principal Investigator
    Sleep, Inflamation, and Depression Occurrence in Breast Cancer Survivors
    NIH R01CA160245Sep 18, 2012 - Aug 31, 2019
    Role: Principal Investigator
    Mechanisms of Sleep Disruption Hyperalgesia
    NIH R01DA032922Jun 1, 2012 - Aug 31, 2018
    Role: Co-Principal Investigator
    Chronic Moderate Sleep Restriction in Older Long and Older Average Sleepers
    NIH R01HL095799Aug 15, 2011 - Jun 30, 2017
    Role: Co-Principal Investigator
    Social Isolation and Sleep Disturance in Aging: Inflammatory Mechanisms
    NIH R01AG034588Sep 15, 2009 - Aug 31, 2015
    Role: Principal Investigator
    Tai Chi Effects on Chronic Insomnia in Breast Cancer Survivors: Immune Mechanisms
    NIH R01CA119159Sep 6, 2006 - Jul 31, 2012
    Role: Principal Investigator
    UCLA Older Americans Independence Center
    NIH P30AG028748Jul 1, 2006 - Jun 30, 2019
    Role: Co-Principal Investigator
    Sleep and Immune Mechanisms in Rheumatoid Arthritis
    NIH R01HL079955May 20, 2006 - Apr 30, 2011
    Role: Principal Investigator
    Aging: Sleep and Inflammatory Mechanisms in Depression Prevention
    NIH R01AG026364Sep 1, 2005 - Feb 28, 2018
    Role: Principal Investigator
    Cocaine Dependence: EEG Sleep and Cytokines
    NIH R01DA016541Sep 30, 2002 - May 31, 2006
    Role: Principal Investigator
    Alcoholism: Sleep and Cytokines in African Americans
    NIH R01AA013239Jun 1, 2001 - Mar 31, 2006
    Role: Principal Investigator
    BEHAVIORAL INTERVENTION FOR HERPES ZOSTER RISK IN AGING
    NIH R01AG018367Sep 1, 2000 - Jul 31, 2005
    Role: Principal Investigator
    TAI CHI CHIH AND VARICELLA ZOSTER IMMUNITY
    NIH R21AT000255Sep 1, 2000 - Jun 30, 2003
    Role: Principal Investigator
    DEPRESSION AND TRIAL OF VARICELLA VACCINE IN THE ELDERLY
    NIH R01MH055253May 15, 2000 - Apr 30, 2005
    Role: Principal Investigator
    Research Perspectives in PNI, Trainee Travel
    NIH R13MH059793Apr 1, 1999 - Nov 30, 2007
    Role: Principal Investigator
    Post-Graduate Training Program in Psychoneuroimmunology and Mental Health
    NIH T32MH019925Jul 25, 1997 - Jun 30, 2014
    Role: Principal Investigator
    ALCOHOLISM--EEG SLEEP AND HEALTH IN AFRICAN AMERICANS
    NIH R01AA010215Apr 1, 1996 - Aug 31, 2001
    Role: Principal Investigator
    DEPRESSION--EEG SLEEP AND NATURAL CYTOTOXICITY
    NIH R01MH046867Sep 1, 1992 - Dec 31, 1995
    Role: Principal Investigator
    DEPRESSION--NEUROPEPTIDES AND NATURAL CYTOTOXICITY
    NIH R29MH044275Aug 1, 1988 - Jul 31, 1994
    Role: Principal Investigator
    Fellowship on Biological Psychiatry and Neuroscience
    NIH T32MH018399Jul 15, 1986 - Jun 30, 2022
    Role: Co-Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Sleep Disturbance as a Mediator of Lung Cancer Stigma on Psychological Distress and Physical Symptom Burden. Psychosom Med. 2024 Feb 27. Williamson TJ, Garon EB, Irwin MR, Choi AK, Goldman JW, Stanton AL. PMID: 38436657.
      View in: PubMed   Mentions:    Fields:    
    2. IL-6 predicts non-suicidal self-injury over 3 months in high-risk adolescents. BJPsych Open. 2024 Feb 26; 10(2):e51. Bai S, Asarnow JR, Babeva KN, Irwin MR. PMID: 38406835; PMCID: PMC10897689.
      View in: PubMed   Mentions:
    3. Sleep-wake behavioral characteristics associated with depression symptoms: Findings from the Multi-Ethnic Study of Atherosclerosis. Sleep. 2024 Feb 23. Lau SCL, Zhang G, Rueschman M, Li X, Irwin MR, Krafty RT, McCall WV, Skidmore E, Patel SR, Redline S, Smagula SF. PMID: 38394355.
      View in: PubMed   Mentions:    Fields:    
    4. Type I interferons, inflammation, and fatigue in a longitudinal RNA study of women with breast cancer. Brain Behav Immun. 2024 May; 118:312-317. Bower JE, Ganz PA, Irwin MR, Crespi CM, Petersen L, Asher A, Hurvitz SA, Cole SW. PMID: 38325563.
      View in: PubMed   Mentions:    Fields:    
    5. The feasibility of a sleep education program for informal dementia care dyads: A pilot randomized controlled trial. J Am Geriatr Soc. 2024 Jan 09. Song Y, Papazyan A, Lee D, Mitchell MN, McCurry SM, Irwin MR, Teng E, Alessi CA, Martin JL. PMID: 38193336.
      View in: PubMed   Mentions:    Fields:    
    6. Work Productivity Among Younger Breast Cancer Survivors: The Impact of Behavioral Interventions for Depression. Value Health. 2024 Mar; 27(3):322-329. Crespi CM, Ganz PA, Partridge AH, Wolff A, Joffe H, Irwin MR, Thure K, Petersen L, Shih YT, Bower JE. PMID: 38135214.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Everyday discrimination, emotion, and daily interactions during adolescence. J Res Adolesc. 2024 Mar; 34(1):141-158. Rahal D, Huynh VW, Irwin MR, McCreath H, Fuligni AJ. PMID: 38058247.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Efficacy of the Transdiagnostic Intervention for Sleep and Circadian Dysfunction for Depression Symptoms and Sleep-Wake Disruption in Older and Younger Adults: Secondary Age-Stratified Analysis of a Randomized Controlled Trial. Am J Geriatr Psychiatry. 2024 Apr; 32(4):478-488. Smagula SF, Gasperetti CE, Buysse DJ, Irwin MR, Krafty RT, Lim SE, Reynolds CF, McCall WV, Harvey AG. PMID: 38040569; PMCID: PMC10950538.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Depressive symptom trajectories in older breast cancer survivors: the Thinking and Living with Cancer Study. J Cancer Surviv. 2023 Nov 04. Nakamura ZM, Small BJ, Zhai W, Ahles TA, Ahn J, Artese AL, Bethea TN, Breen EC, Cohen HJ, Extermann M, Graham D, Irwin MR, Isaacs C, Jim HSL, Kuhlman KR, McDonald BC, Patel SK, Rentscher KE, Root JC, Saykin AJ, Tometich DB, Van Dyk K, Zhou X, Mandelblatt JS, Carroll JE. PMID: 37924476.
      View in: PubMed   Mentions: 1     Fields:    
    10. Heightened neural activity and functional connectivity responses to social rejection in female adolescents at risk for depression: Testing the Social Signal Transduction Theory of Depression. J Affect Disord. 2024 01 15; 345:467-476. Shields GS, Vinograd M, Bui T, Sichko S, Irwin MR, Slavich GM. PMID: 37852590.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    11. Disturbance of sleep maintenance, but not sleep duration, activates nuclear factor-κB and signal transducer and activator of transcription family proteins in older adults: sex differences. Sleep. 2023 10 11; 46(10). Piber D, Olmstead R, Cho JH, Irwin MR. PMID: 37140651; PMCID: PMC10566249.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. Executive functioning trajectories and their prospective association with inflammatory biomarkers in schizophrenia and non-psychiatric comparison participants. Prog Neuropsychopharmacol Biol Psychiatry. 2024 Jan 10; 128:110866. Adamowicz DH, Wu TC, Daly R, Irwin MR, Jeste DV, Tu XM, Eyler LT, Lee EE. PMID: 37742747; PMCID: PMC10829566.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    13. Alcohol use disorder (AUD) is associated with enhanced sensitivity to cellular lipopolysaccharide challenge. Alcohol Clin Exp Res (Hoboken). 2023 Oct; 47(10):1859-1868. Burnette EM, Grodin EN, Olmstead R, Ray LA, Irwin MR. PMID: 37864529; PMCID: PMC10830126.
      View in: PubMed   Mentions: 1  
    14. Inflammation-related proteins as biomarkers of treatment-related behavioral symptoms: A longitudinal study of breast cancer patients and age-matched controls. Brain Behav Immun Health. 2023 Oct; 32:100670. Patel SK, Breen EC, Paz IB, Kruper L, Mortimer J, Wong FL, Bhatia S, Irwin MR, Behrendt CE. PMID: 37637432; PMCID: PMC10450410.
      View in: PubMed   Mentions:
    15. Heat of the night: sleep disturbance activates inflammatory mechanisms and induces pain in rheumatoid arthritis. Nat Rev Rheumatol. 2023 09; 19(9):545-559. Irwin MR, Straub RH, Smith MT. PMID: 37488298.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. Stress to inflammation and anhedonia: Mechanistic insights from preclinical and clinical models. Neurosci Biobehav Rev. 2023 09; 152:105307. Boyle CC, Bower JE, Eisenberger NI, Irwin MR. PMID: 37419230.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    17. A randomized, placebo-controlled, double-blinded mechanistic clinical trial using endotoxin to evaluate the relationship between insomnia, inflammation, and affective disturbance on pain in older adults: A protocol for the sleep and Healthy Aging Research for pain (SHARE-P) study. Brain Behav Immun Health. 2023 Jul; 30:100642. DuPont CM, Olmstead R, Reid MJ, Hamilton KR, Campbell CM, Finan PH, Sadeghi N, Castillo D, Irwin MR, Smith MT. PMID: 37256193; PMCID: PMC10225887.
      View in: PubMed   Mentions:
    18. Bilateral risk-reducing mastectomy and reconstruction-A 12-year review of methodological trends and outcomes at a tertiary referral centre. PLoS One. 2023; 18(4):e0281601. Aslam A, Arshad Z, Ahmed A, Soh CL, Kazzazi F, Benson JR, Forouhi P, Agrawal A, Benyon SL, Irwin M, Malata CM. PMID: 37043488; PMCID: PMC10096181.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    19. Socioeconomic Status, Reserve Capacity, and Depressive Symptoms Predict Pain in Rheumatoid Arthritis: An Examination of the Reserve Capacity Model. Res Sq. 2023 Apr 07. Azizoddin D, Olmstead R, Anderson KA, Hirz AE, Irwin MR, Gholizadeh S, Weisman M, Ishimori M, Wallace D, Nicassio P. PMID: 37066198; PMCID: PMC10104260.
      View in: PubMed   Mentions:
    20. A meta-analysis of the associations between insufficient sleep duration and antibody response to vaccination. Curr Biol. 2023 03 13; 33(5):998-1005.e2. Spiegel K, Rey AE, Cheylus A, Ayling K, Benedict C, Lange T, Prather AA, Taylor DJ, Irwin MR, Van Cauter E. PMID: 36917932.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansPHPublic Health
    21. Remission of insomnia in older adults treated with cognitive behavioral therapy for insomnia (CBT-I) reduces p16INK4a gene expression in peripheral blood: secondary outcome analysis from a randomized clinical trial. Geroscience. 2023 Aug; 45(4):2325-2335. Carroll JE, Olmstead R, Cole SW, Breen EC, Arevalo JM, Irwin MR. PMID: 36849678; PMCID: PMC10651570.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    22. Salivary cortisol awakening levels are reduced in human subjects with intermittent explosive disorder compared with controls. Psychoneuroendocrinology. 2023 05; 151:106070. Meruelo AD, Timmins MA, Irwin MR, Coccaro EF. PMID: 36863129; PMCID: PMC10262314.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    23. Plasma and cerebrospinal fluid inflammatory markers and human aggression. Neuropsychopharmacology. 2023 06; 48(7):1060-1066. Coccaro EF, Lee R, Breen EC, Irwin MR. PMID: 36804488; PMCID: PMC10209212.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    24. Sleep and Healthy Aging Research on Depression (SHARE-D) randomized controlled trial: Protocol overview of an experimental model of depression with insomnia, inflammation, and affect mechanisms in older adults. Brain Behav Immun Health. 2023 Mar; 28:100601. Irwin MR, Boyle CC, Cho JH, Piber D, Breen EC, Sadeghi N, Castillo D, Smith M, Eisenberger NI, Olmstead R. PMID: 36879913; PMCID: PMC9984307.
      View in: PubMed   Mentions: 1  
    25. Improving biobehavioral health in younger breast cancer survivors: Pathways to Wellness trial secondary outcomes. J Natl Cancer Inst. 2023 01 10; 115(1):83-92. Bower JE, Partridge AH, Wolff AC, Cole SW, Irwin MR, Thorner ED, Joffe H, Petersen L, Crespi CM, Ganz PA. PMID: 36130057; PMCID: PMC9830488.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    26. The role of inflammation in acute psychosocial stress-induced modulation of reward processing in healthy female adults. Brain Behav Immun Health. 2023 Mar; 28:100588. Boyle CC, Cole SW, Irwin MR, Eisenberger NI, Bower JE. PMID: 36683947; PMCID: PMC9853307.
      View in: PubMed   Mentions:
    27. The role of early life adversity and inflammation in stress-induced change in reward and risk processes among adolescents. Brain Behav Immun. 2023 03; 109:78-88. Kuhlman KR, Cole SW, Irwin MR, Craske MG, Fuligni AJ, Bower JE. PMID: 36621653; PMCID: PMC10112053.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    28. Structural brain plasticity and inflammation are independently related to changes in depressive symptoms six months after an index ECT course. Psychol Med. 2024 Jan; 54(1):108-116. Brooks JO, Kruse JL, Kubicki A, Hellemann G, Espinoza RT, Irwin MR, Narr KL. PMID: 36600668.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    29. Insomnia symptoms predict longer COVID-19 symptom duration. Sleep Med. 2023 01; 101:365-372. Vargas I, Muench A, Grandner MA, Irwin MR, Perlis ML. PMID: 36493657; PMCID: PMC9682867.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCellsPHPublic Health
    30. Effects of Tai Chi and cognitive behavioral therapy for insomnia on improving sleep in older adults: Study protocol for a non-inferiority trial. J Exerc Sci Fit. 2023 Jan; 21(1):67-73. Yu DJ, Yu AP, Li SX, Chan RNY, Fong DY, Chan DKC, Hui SS, Chung KF, Woo J, Wang C, Irwin MR, Siu PM. PMID: 36408205; PMCID: PMC9663887.
      View in: PubMed   Mentions:
    31. Association of Physical Activity With Risk of Mortality Among Breast Cancer Survivors. JAMA Netw Open. 2022 Nov 01; 5(11):e2242660. Chen LH, Irwin MR, Olmstead R, Haque R. PMID: 36394875; PMCID: PMC9672970.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    32. Sleep disruption and activation of cellular inflammation mediate heightened pain sensitivity: a randomized clinical trial. Pain. 2023 05 01; 164(5):1128-1137. Irwin MR, Olmstead R, Bjurstrom MF, Finan PH, Smith MT. PMID: 36314570; PMCID: PMC10106531.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    33. Baseline C-reactive protein levels are predictive of treatment response to a neuroimmune modulator in individuals with an alcohol use disorder: a preliminary study. Am J Drug Alcohol Abuse. 2023 05 04; 49(3):333-344. Grodin EN, Meredith LR, Burnette EM, Miotto K, Irwin MR, Ray LA. PMID: 36282988; PMCID: PMC10840759.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    34. Resting respiratory sinus arrhythmia is related to emotion reactivity to social-evaluative stress. J Affect Disord. 2023 01 01; 320:725-734. Rahal D, Bower JE, Irwin MR, Fuligni AJ, Chiang JJ. PMID: 36162680; PMCID: PMC10392612.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    35. Antidepressant medication use and prostate cancer recurrence in men with depressive disorders. Cancer Causes Control. 2022 Nov; 33(11):1363-1372. Haque R, Reading S, Irwin MR, Chen LH, Slezak J. PMID: 36083407; PMCID: PMC9519663.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    36. Sleep disruption induces activation of inflammation and heightens risk for infectious disease: Role of impairments in thermoregulation and elevated ambient temperature. Temperature (Austin). 2023; 10(2):198-234. Irwin MR. PMID: 37332305; PMCID: PMC10274531.
      View in: PubMed   Mentions: 2  
    37. Sleep disturbance and activation of cellular and transcriptional mechanisms of inflammation in older adults. Brain Behav Immun. 2022 11; 106:67-75. Piber D, Cho JH, Lee O, Lamkin DM, Olmstead R, Irwin MR. PMID: 35953022.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    38. Acute health-related quality of life outcomes and systemic inflammatory markers following contemporary breast cancer surgery. NPJ Breast Cancer. 2022 Aug 08; 8(1):91. Radin AS, Bower JE, Irwin MR, Asher A, Hurvitz SA, Cole SW, Crespi CM, Ganz PA. PMID: 35941136; PMCID: PMC9359976.
      View in: PubMed   Mentions: 1  
    39. Psychosocial Resilience to Inflammation-Associated Depression: A Prospective Study of Breast-Cancer Survivors. Psychol Sci. 2022 08; 33(8):1328-1339. Manigault AW, Kuhlman KR, Irwin MR, Cole SW, Ganz PA, Crespi CM, Bower JE. PMID: 35930691; PMCID: PMC9527532.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    40. Frontostriatal functional connectivity underlies self-enhancement during social evaluation. Soc Cogn Affect Neurosci. 2022 08 01; 17(8):723-731. Parrish MH, Dutcher JM, Muscatell KA, Inagaki TK, Moieni M, Irwin MR, Eisenberger NI. PMID: 34984459; PMCID: PMC9340112.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    41. Interleukin-8 and depressive responses to an inflammatory challenge: secondary analysis of a randomized controlled trial. Sci Rep. 2022 07 24; 12(1):12627. Kruse JL, Boyle CC, Olmstead R, Breen EC, Tye SJ, Eisenberger NI, Irwin MR. PMID: 35871638; PMCID: PMC9309160.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    42. Psychiatric symptoms are not associated with circulating CRP concentrations after controlling for medical, social, and demographic factors. Transl Psychiatry. 2022 07 12; 12(1):279. Figueroa-Hall LK, Xu B, Kuplicki R, Ford BN, Burrows K, Teague TK, Sen S, Yeh HW, Irwin MR, Savitz J, Paulus MP. PMID: 35821205; PMCID: PMC9276683.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    43. Association of interleukin-8 and risk of incident and recurrent depression in long-term breast cancer survivors. Brain Behav Immun. 2022 10; 105:131-138. Irwin MR, Olmstead R, Kruse J, Breen EC, Haque R. PMID: 35803481.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    44. Acute and Chronic Effects of Adjuvant Therapy on Inflammatory Markers in Breast Cancer Patients. JNCI Cancer Spectr. 2022 07 01; 6(4). Bower JE, Ganz PA, Irwin MR, Cole SW, Carroll J, Kuhlman KR, Petersen L, Garet D, Asher A, Hurvitz SA, Crespi CM. PMID: 35900175; PMCID: PMC9420043.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    45. Effects of ibudilast on central and peripheral markers of inflammation in alcohol use disorder: A randomized clinical trial. Addict Biol. 2022 07; 27(4):e13182. Grodin EN, Nieto SJ, Meredith LR, Burnette E, O'Neill J, Alger J, London ED, Miotto K, Evans CJ, Irwin MR, Ray LA. PMID: 35754106; PMCID: PMC9888600.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    46. Hybrid Delivery of Mindfulness Meditation and Perceived Stress in Pediatric Resident Physicians: A Randomized Clinical Trial of In-Person and Digital Mindfulness Meditation. J Clin Psychol Med Settings. 2023 06; 30(2):425-434. Purdie DR, Federman M, Chin A, Winston D, Bursch B, Olmstead R, Bulut Y, Irwin MR. PMID: 35778655; PMCID: PMC10078965.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    47. Associations between peripheral inflammatory markers and amygdala activity and connectivity in response to emotional faces in adolescents. Brain Behav Immun. 2022 10; 105:98-108. Swartz JR, Carranza AF, Knodt AR, Irwin MR, Hostinar CE. PMID: 35781009; PMCID: PMC9531728.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    48. The Relationship Between Family Socioeconomic Status and Adolescent Sleep and Diurnal Cortisol. Psychosom Med. 2022 09 01; 84(7):848-855. Rocha S, Almeida DM, Chiang JJ, Cole SW, Irwin MR, Seeman T, Fuligni AJ. PMID: 35797448; PMCID: PMC9437129.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    49. Accelerated mononuclear cell telomere attrition in breast cancer survivors with depression history: A 2-year longitudinal cohort study. Cancer. 2022 08 15; 128(16):3109-3119. Carroll JE, Olmstead R, Haque R, Irwin MR. PMID: 35670038.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    50. Younger women are more susceptible to inflammation: A longitudinal examination of the role of aging in inflammation and depressive symptoms. J Affect Disord. 2022 08 01; 310:328-336. Kuhlman KR, Irwin MR, Ganz PA, Cole SW, Manigault AW, Crespi CM, Bower JE. PMID: 35561889.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    51. The Direct Effect of Cognitive Behavioral Therapy for Insomnia on Depression Prevention and the Mediation Effect via Insomnia Remission-Reply. JAMA Psychiatry. 2022 05 01; 79(5):515. Irwin MR, Olmstead R. PMID: 35293960.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    52. Enhanced Immune Activation Following Acute Social Stress Among Adolescents With Early-Life Adversity. Biol Psychiatry Glob Open Sci. 2023 Apr; 3(2):213-221. Kuhlman KR, Cole SW, Craske MG, Fuligni AJ, Irwin MR, Bower JE. PMID: 37124349; PMCID: PMC10140462.
      View in: PubMed   Mentions: 4  
    53. Associations between inflammatory marker profiles and neurocognitive functioning in people with schizophrenia and non-psychiatric comparison subjects. J Psychiatr Res. 2022 05; 149:106-113. Adamowicz DH, Shilling PD, Palmer BW, Nguyen TT, Wang E, Liu C, Tu X, Jeste DV, Irwin MR, Lee EE. PMID: 35259663; PMCID: PMC9933244.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    54. Response to: 'The relationship between preoperative sleep quality and adverse pain outcomes is still unclear-A comment on Bjurström et al.' Eur J Pain. 2022 05; 26(5):1177-1178. Bjurström MF, Smith MT, Olmstead R, Irwin MR. PMID: 35212077.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    55. Costs associated with treatment of insomnia in Alzheimer's disease caregivers: a comparison of mindfulness meditation and cognitive behavioral therapy for insomnia. BMC Health Serv Res. 2022 Feb 19; 22(1):231. Bentley TGK, Castillo D, Sadeghi N, Piber D, Carroll J, Olmstead R, Irwin MR. PMID: 35183180; PMCID: PMC8858547.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    56. Interferon-γ moderation of poor sleep maintenance and depressed mood in community-dwelling older adults. Psychol Med. 2023 Jun; 53(8):3548-3556. Piber D, Olmstead R, Cho JH, Guzman M, Irwin MR. PMID: 35144705.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    57. Central nervous system monoaminergic activity in hip osteoarthritis patients with disabling pain: associations with pain severity and central sensitization. Pain Rep. 2022 Jan-Feb; 7(1):e988. Bjurström MF, Blennow K, Zetterberg H, Bodelsson M, Waldén M, Dietz N, Hall S, Hansson O, Irwin MR, Mattsson-Carlgren N. PMID: 35097309; PMCID: PMC8789209.
      View in: PubMed   Mentions: 6  
    58. Prevention of Incident and Recurrent Major Depression in Older Adults With Insomnia: A Randomized Clinical Trial. JAMA Psychiatry. 2022 01 01; 79(1):33-41. Irwin MR, Carrillo C, Sadeghi N, Bjurstrom MF, Breen EC, Olmstead R. PMID: 34817561; PMCID: PMC8733847.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    59. Elevated Systemic Inflammation Is Associated with Reduced Corticolimbic White Matter Integrity in Depression. Life (Basel). 2021 Dec 28; 12(1). Thomas M, Savitz J, Zhang Y, Burrows K, Smith R, Figueroa-Hall L, Kuplicki R, Khalsa SS, Taki Y, Teague TK, Irwin MR, Yeh FC, Paulus MP, Zheng H. PMID: 35054436; PMCID: PMC8778940.
      View in: PubMed   Mentions: 4  
    60. Moderators of inflammation-related depression: a prospective study of breast cancer survivors. Transl Psychiatry. 2021 12 06; 11(1):615. Manigault AW, Ganz PA, Irwin MR, Cole SW, Kuhlman KR, Bower JE. PMID: 34873150; PMCID: PMC8648787.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
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    203. Parental support buffers the association of depressive symptoms with cortisol and C-reactive protein during adolescence. Brain Behav Immun. 2016 Oct; 57:134-143. Guan SA, Bower JE, Almeida DM, Cole SW, Dahl RE, Irwin MR, Seeman TE, McDade T, Fuligni AJ. PMID: 26995316; PMCID: PMC5010993.
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    205. Insomnia and Telomere Length in Older Adults. Sleep. 2016 Mar 01; 39(3):559-64. Carroll JE, Esquivel S, Goldberg A, Seeman TE, Effros RB, Dock J, Olmstead R, Breen EC, Irwin MR. PMID: 26715231; PMCID: PMC4763369.
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    207. Emotional acceptance, inflammation, and sickness symptoms across the first two years following breast cancer diagnosis. Brain Behav Immun. 2016 Aug; 56:165-74. Reed RG, Weihs KL, Sbarra DA, Breen EC, Irwin MR, Butler EA. PMID: 26916219; PMCID: PMC4917434.
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    208. Sleep quality and depressive symptoms after prostate cancer: The mechanistic role of cortisol. Behav Neurosci. 2016 06; 130(3):351-6. Hoyt MA, Bower JE, Irwin MR, Weierich MR, Stanton AL. PMID: 26820589; PMCID: PMC4877249.
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    209. Opioids and social bonding: naltrexone reduces feelings of social connection. Soc Cogn Affect Neurosci. 2016 05; 11(5):728-35. Inagaki TK, Ray LA, Irwin MR, Way BM, Eisenberger NI. PMID: 26796966; PMCID: PMC4847702.
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    210. Impact of social isolation on behavioral health in elderly: Systematic review. World J Psychiatry. 2015 Dec 22; 5(4):432-8. Choi H, Irwin MR, Cho HJ. PMID: 26740935; PMCID: PMC4694557.
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    213. Partial sleep deprivation activates the DNA damage response (DDR) and the senescence-associated secretory phenotype (SASP) in aged adult humans. Brain Behav Immun. 2016 Jan; 51:223-229. Carroll JE, Cole SW, Seeman TE, Breen EC, Witarama T, Arevalo JMG, Ma J, Irwin MR. PMID: 26336034; PMCID: PMC4679552.
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    217. Self-reported sleep duration mitigates the association between inflammation and cognitive functioning in hospitalized older men. Front Psychol. 2015; 6:1004. Dzierzewski JM, Song Y, Fung CH, Rodriguez JC, Jouldjian S, Alessi CA, Breen EC, Irwin MR, Martin JL. PMID: 26257670; PMCID: PMC4508491.
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    220. Inflammatory Biomarkers, Comorbidity, and Neurocognition in Women With Newly Diagnosed Breast Cancer. J Natl Cancer Inst. 2015 Aug; 107(8). Patel SK, Wong AL, Wong FL, Breen EC, Hurria A, Smith M, Kinjo C, Paz IB, Kruper L, Somlo G, Mortimer JE, Palomares MR, Irwin MR, Bhatia S. PMID: 26101331; PMCID: PMC4609551.
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    221. Blocking opioids attenuates physical warmth-induced feelings of social connection. Emotion. 2015 Aug; 15(4):494-500. Inagaki TK, Irwin MR, Eisenberger NI. PMID: 26098729; PMCID: PMC4516568.
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    222. Yearning for connection? Loneliness is associated with increased ventral striatum activity to close others. Soc Cogn Affect Neurosci. 2016 07; 11(7):1096-101. Inagaki TK, Muscatell KA, Moieni M, Dutcher JM, Jevtic I, Irwin MR, Eisenberger NI. PMID: 26084531; PMCID: PMC4927031.
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    223. Preventive Treatment with Ketamine Attenuates the Ischaemia-Reperfusion Response in a Chronic Postischaemia Pain Model. Oxid Med Cell Longev. 2015; 2015:380403. Liman S, Cheung CW, Wong KL, Tai W, Qiu Q, Ng KF, Choi SW, Irwin M. PMID: 26161236; PMCID: PMC4487903.
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    224. Sleep Disturbance, Sleep Duration, and Inflammation: A Systematic Review and Meta-Analysis of Cohort Studies and Experimental Sleep Deprivation. Biol Psychiatry. 2016 07 01; 80(1):40-52. Irwin MR, Olmstead R, Carroll JE. PMID: 26140821; PMCID: PMC4666828.
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    225. Polysomnographic characteristics in nonmalignant chronic pain populations: A review of controlled studies. Sleep Med Rev. 2016 Apr; 26:74-86. Bjurstrom MF, Irwin MR. PMID: 26140866; PMCID: PMC4598249.
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    226. Socioeconomic status, daily affective and social experiences, and inflammation during adolescence. Psychosom Med. 2015 Apr; 77(3):256-66. Chiang JJ, Bower JE, Almeida DM, Irwin MR, Seeman TE, Fuligni AJ. PMID: 25829237; PMCID: PMC4397124.
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    227. Mindfulness meditation and improvement in sleep quality and daytime impairment among older adults with sleep disturbances: a randomized clinical trial. JAMA Intern Med. 2015 Apr; 175(4):494-501. Black DS, O'Reilly GA, Olmstead R, Breen EC, Irwin MR. PMID: 25686304; PMCID: PMC4407465.
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    228. Inflammation impairs social cognitive processing: A randomized controlled trial of endotoxin. Brain Behav Immun. 2015 Aug; 48:132-8. Moieni M, Irwin MR, Jevtic I, Breen EC, Eisenberger NI. PMID: 25770082; PMCID: PMC4508216.
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    229. Opioid treatment of experimental pain activates nuclear factor-κB. J Opioid Manag. 2015 Mar-Apr; 11(2):115-25. Compton P, Griffis C, Breen EC, Torrington M, Sadakane R, Tefera E, Irwin MR. PMID: 25901477; PMCID: PMC4507428.
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    230. Sleep disturbance and longitudinal risk of inflammation: Moderating influences of social integration and social isolation in the Coronary Artery Risk Development in Young Adults (CARDIA) study. Brain Behav Immun. 2015 May; 46:319-26. Cho HJ, Seeman TE, Kiefe CI, Lauderdale DS, Irwin MR. PMID: 25733101; PMCID: PMC4414819.
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    231. Improved sleep quality in older adults with insomnia reduces biomarkers of disease risk: pilot results from a randomized controlled comparative efficacy trial. Psychoneuroendocrinology. 2015 May; 55:184-92. Carroll JE, Seeman TE, Olmstead R, Melendez G, Sadakane R, Bootzin R, Nicassio P, Irwin MR. PMID: 25770704; PMCID: PMC4422640.
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    232. Sleep and multisystem biological risk: a population-based study. PLoS One. 2015; 10(2):e0118467. Carroll JE, Irwin MR, Stein Merkin S, Seeman TE. PMID: 25714703; PMCID: PMC4340787.
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    238. Sleep loss activates cellular inflammation and signal transducer and activator of transcription (STAT) family proteins in humans. Brain Behav Immun. 2015 Jul; 47:86-92. Irwin MR, Witarama T, Caudill M, Olmstead R, Breen EC. PMID: 25451613; PMCID: PMC4401620.
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    245. Tai chi meditation effects on nuclear factor-κB signaling in lonely older adults: a randomized controlled trial. Psychother Psychosom. 2014; 83(5):315-7. Black DS, Irwin MR, Olmstead R, Ji E, Crabb Breen E, Motivala SJ. PMID: 25116908; PMCID: PMC4165547.
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    246. Why sleep is important for health: a psychoneuroimmunology perspective. Annu Rev Psychol. 2015 Jan 03; 66:143-72. Irwin MR. PMID: 25061767; PMCID: PMC4961463.
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    247. Approach and avoidance coping: diurnal cortisol rhythm in prostate cancer survivors. Psychoneuroendocrinology. 2014 Nov; 49:182-6. Hoyt MA, Marin-Chollom AM, Bower JE, Thomas KS, Irwin MR, Stanton AL. PMID: 25108161; PMCID: PMC4165795.
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    248. Greater amygdala activity and dorsomedial prefrontal-amygdala coupling are associated with enhanced inflammatory responses to stress. Brain Behav Immun. 2015 Jan; 43:46-53. Muscatell KA, Dedovic K, Slavich GM, Jarcho MR, Breen EC, Bower JE, Irwin MR, Eisenberger NI. PMID: 25016200; PMCID: PMC4368432.
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    249. Effect of depression on diagnosis, treatment, and mortality of men with clinically localized prostate cancer. J Clin Oncol. 2014 Aug 10; 32(23):2471-8. Prasad SM, Eggener SE, Lipsitz SR, Irwin MR, Ganz PA, Hu JC. PMID: 25002728; PMCID: PMC4121505.
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    250. The effects of mind-body therapies on the immune system: meta-analysis. PLoS One. 2014; 9(7):e100903. Morgan N, Irwin MR, Chung M, Wang C. PMID: 24988414; PMCID: PMC4079606.
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    251. Persistent depressive symptoms and pain after cardiac surgery. Psychosom Med. 2014 Jul-Aug; 76(6):437-44. Doering LV, Chen B, McGuire A, Bodán RC, Irwin MR. PMID: 24979578; PMCID: PMC4139703.
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    256. From stress to inflammation and major depressive disorder: a social signal transduction theory of depression. Psychol Bull. 2014 May; 140(3):774-815. Slavich GM, Irwin MR. PMID: 24417575; PMCID: PMC4006295.
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    257. Divergent gene expression responses to complicated grief and non-complicated grief. Brain Behav Immun. 2014 Mar; 37:78-83. O'Connor MF, Schultze-Florey CR, Irwin MR, Arevalo JMG, Cole SW. PMID: 24380850; PMCID: PMC4015725.
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    258. Depression and insomnia in cancer: prevalence, risk factors, and effects on cancer outcomes. Curr Psychiatry Rep. 2013 Nov; 15(11):404. Irwin MR. PMID: 24078066; PMCID: PMC3836364.
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    259. Persistent sleep disturbance: a risk factor for recurrent depression in community-dwelling older adults. Sleep. 2013 Nov 01; 36(11):1685-91. Lee E, Cho HJ, Olmstead R, Levin MJ, Oxman MN, Irwin MR. PMID: 24179302; PMCID: PMC3792386.
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    261. In patients with stable heart failure, soluble TNF-receptor 2 is associated with increased risk for depressive symptoms. Biol Res Nurs. 2014 Jul; 16(3):295-302. Moughrabi S, Evangelista LS, Habib SI, Kassabian L, Breen EC, Nyamathi A, Irwin M. PMID: 23904128; PMCID: PMC4447109.
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    286. Post-traumatic disorder symptoms and blunted diurnal cortisol production in partners of prostate cancer patients. Psychoneuroendocrinology. 2012 Aug; 37(8):1181-90. Thomas KS, Bower JE, Williamson TJ, Hoyt MA, Wellisch D, Stanton AL, Irwin M. PMID: 22222119; PMCID: PMC3350754.
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    287. Clinical psychoneuroimmunology. Handb Clin Neurol. 2012; 106:211-25. Irwin MR, Rothermundt M. PMID: 22608623.
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    295. Reciprocal regulation of the neural and innate immune systems. Nat Rev Immunol. 2011 08 05; 11(9):625-32. Irwin MR, Cole SW. PMID: 21818124; PMCID: PMC3597082.
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    296. Antagonistic pleiotropy at the human IL6 promoter confers genetic resilience to the pro-inflammatory effects of adverse social conditions in adolescence. Dev Psychol. 2011 Jul; 47(4):1173-80. Cole SW, Arevalo JM, Manu K, Telzer EH, Kiang L, Bower JE, Irwin MR, Fuligni AJ. PMID: 21639625; PMCID: PMC3592928.
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    300. Fatigue and gene expression in human leukocytes: increased NF-κB and decreased glucocorticoid signaling in breast cancer survivors with persistent fatigue. Brain Behav Immun. 2011 Jan; 25(1):147-50. Bower JE, Ganz PA, Irwin MR, Arevalo JM, Cole SW. PMID: 20854893; PMCID: PMC3603145.
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    301. Inflammation-induced anhedonia: endotoxin reduces ventral striatum responses to reward. Biol Psychiatry. 2010 Oct 15; 68(8):748-54. Eisenberger NI, Berkman ET, Inagaki TK, Rameson LT, Mashal NM, Irwin MR. PMID: 20719303; PMCID: PMC3025604.
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    308. Spontaneous cardiomyopathy in cynomolgus monkeys (Macaca fascicularis). Toxicol Pathol. 2009 Oct; 37(6):814-8. Zabka TS, Irwin M, Albassam MA. PMID: 19706931.
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    313. Depression and immunity: inflammation and depressive symptoms in multiple sclerosis. Immunol Allergy Clin North Am. 2009 May; 29(2):309-20. Gold SM, Irwin MR. PMID: 19389584; PMCID: PMC3625861.
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    319. Nocturnal levels of ghrelin and leptin and sleep in chronic insomnia. Psychoneuroendocrinology. 2009 May; 34(4):540-5. Motivala SJ, Tomiyama AJ, Ziegler M, Khandrika S, Irwin MR. PMID: 19059729; PMCID: PMC2725023.
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    321. Behavioral Comorbidities in Rheumatoid Arthritis: A Psychoneuroimmunological Perspective. Psychiatr Times. 2008 Aug 01; 25(9):1. Irwin MR, Davis M, Zautra A. PMID: 19590742; PMCID: PMC2707019.
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    328. Neuroendocrine-immune mechanisms of behavioral comorbidities in patients with cancer. J Clin Oncol. 2008 Feb 20; 26(6):971-82. Miller AH, Ancoli-Israel S, Bower JE, Capuron L, Irwin MR. PMID: 18281672; PMCID: PMC2770012.
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    354. Inflammatory biomarkers for persistent fatigue in breast cancer survivors. Clin Cancer Res. 2006 May 01; 12(9):2759-66. Collado-Hidalgo A, Bower JE, Ganz PA, Cole SW, Irwin MR. PMID: 16675568.
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    355. Loss of slow-wave sleep. J Clin Sleep Med. 2006 Apr 15; 2(2):213-4. Eljammal SM, Valladares EM, Irwin MR. PMID: 17557497.
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    356. Comparative meta-analysis of behavioral interventions for insomnia and their efficacy in middle-aged adults and in older adults 55+ years of age. Health Psychol. 2006 Jan; 25(1):3-14. Irwin MR, Cole JC, Nicassio PM. PMID: 16448292.
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    357. Validation of a 3-factor scoring model for the Pittsburgh sleep quality index in older adults. Sleep. 2006 Jan; 29(1):112-6. Cole JC, Motivala SJ, Buysse DJ, Oxman MN, Levin MJ, Irwin MR. PMID: 16453989.
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    358. Association between nocturnal vagal tone and sleep depth, sleep quality, and fatigue in alcohol dependence. Psychosom Med. 2006 Jan-Feb; 68(1):159-66. Irwin MR, Valladares EM, Motivala S, Thayer JF, Ehlers CL. PMID: 16449427.
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    359. Visual EEG differences in abstinent alcohol dependence and ethnicity. Sleep Med. 2006 Jan; 7(1):79-80. Valladares EM, Irwin M. PMID: 16314146.
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    360. Validation of single-factor structure and scoring protocol for the Health Assessment Questionnaire-Disability Index. Arthritis Rheum. 2005 Aug 15; 53(4):536-42. Cole JC, Motivala SJ, Khanna D, Lee JY, Paulus HE, Irwin MR. PMID: 16082630.
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    361. Dissociation of inflammatory markers and natural killer cell activity in major depressive disorder. Brain Behav Immun. 2006 Mar; 20(2):169-74. Pike JL, Irwin MR. PMID: 16023828.
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    362. Macrophage colony-stimulating factor expression in retrovirally transduced cells is dependent upon both the adherence status of the target cells and its 5' flanking untranslated region. Biochem Biophys Res Commun. 2005 May 20; 330(4):1275-84. Zhang JG, Dan Q, Fong TC, Williams CC, Avina MD, Tarbiyat-Boldaji M, Khalaghizadeh S, Irwin M, Nguyen A, Zhuang JL, Hoa N, Wepsic HT, Jadus MR. PMID: 15823581.
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    363. Inflammatory markers and sleep disturbance in major depression. Psychosom Med. 2005 Mar-Apr; 67(2):187-94. Motivala SJ, Sarfatti A, Olmos L, Irwin MR. PMID: 15784782.
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    364. Sleep deprivation potentiates activation of cardiovascular and catecholamine responses in abstinent alcoholics. Hypertension. 2005 Feb; 45(2):252-7. Irwin MR, Ziegler M. PMID: 15642774.
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    365. Shingles Immunity and Health Functioning in the Elderly: Tai Chi Chih as a Behavioral Treatment. Evid Based Complement Alternat Med. 2004 12; 1(3):223-232. Irwin M, Pike J, Oxman M. PMID: 15841255; PMCID: PMC538519.
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    366. Spurious tumor necrosis factor-alpha and interleukin-6 production by human monocytes from blood collected in endotoxin-contaminated vacutainer blood collection tubes. Clin Chem. 2004 Nov; 50(11):2215-6. Aziz N, Irwin MR, Dickerson SS, Butch AW. PMID: 15502103.
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    367. Cellular adhesion molecule expression, nocturnal sleep, and partial night sleep deprivation. Brain Behav Immun. 2004 Jul; 18(4):333-40. Redwine L, Dang J, Irwin M. PMID: 15157950.
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    368. Nocturnal proinflammatory cytokine-associated sleep disturbances in abstinent African American alcoholics. Brain Behav Immun. 2004 Jul; 18(4):349-60. Irwin M, Rinetti G, Redwine L, Motivala S, Dang J, Ehlers C. PMID: 15157952.
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    369. Immune activation and depression in women with rheumatoid arthritis. J Rheumatol. 2004 Mar; 31(3):457-63. Zautra AJ, Yocum DC, Villanueva I, Smith B, Davis MC, Attrep J, Irwin M. PMID: 14994388.
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    370. The association between major depression and levels of soluble intercellular adhesion molecule 1, interleukin-6, and C-reactive protein in patients with recent acute coronary syndromes. Am J Psychiatry. 2004 Feb; 161(2):271-7. Lespérance F, Frasure-Smith N, Théroux P, Irwin M. PMID: 14754776.
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    371. Disordered sleep, nocturnal cytokines, and immunity: interactions between alcohol dependence and African-American ethnicity. Alcohol. 2004 Jan; 32(1):53-61. Irwin MR, Rinetti G. PMID: 15066704.
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    372. Abnormal nocturnal melatonin secretion and disordered sleep in abstinent alcoholics. Biol Psychiatry. 2003 Dec 15; 54(12):1437-43. Kühlwein E, Hauger RL, Irwin MR. PMID: 14675809.
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    373. Leptin and cellular and innate immunity in abstinent alcoholics and controls. Alcohol Clin Exp Res. 2003 Nov; 27(11):1819-24. Motivala SJ, Dang J, Obradovic T, Meadows GG, Butch AW, Irwin MR. PMID: 14634499.
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    374. Nocturnal catecholamines and immune function in insomniacs, depressed patients, and control subjects. Brain Behav Immun. 2003 Oct; 17(5):365-72. Irwin M, Clark C, Kennedy B, Christian Gillin J, Ziegler M. PMID: 12946658.
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    375. Effects of a behavioral intervention, Tai Chi Chih, on varicella-zoster virus specific immunity and health functioning in older adults. Psychosom Med. 2003 Sep-Oct; 65(5):824-30. Irwin MR, Pike JL, Cole JC, Oxman MN. PMID: 14508027.
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    376. Acute psychological stress: effects on chemotaxis and cellular adhesion molecule expression. Psychosom Med. 2003 Jul-Aug; 65(4):598-603. Redwine L, Snow S, Mills P, Irwin M. PMID: 12883110.
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    377. Disordered sleep, nocturnal cytokines, and immunity in alcoholics. Psychosom Med. 2003 Jan-Feb; 65(1):75-85. Redwine L, Dang J, Hall M, Irwin M. PMID: 12554818.
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    378. Health consequences of Alzheimer's caregiving transitions: effects of placement and bereavement. Psychosom Med. 2002 May-Jun; 64(3):477-86. Grant I, Adler KA, Patterson TL, Dimsdale JE, Ziegler MG, Irwin MR. PMID: 12021421.
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