Nicholas A Cacalano

Title(s)Associate Professor, Radiation Oncology
SchoolMedicine
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Novel Dormancy Mechanism of Castration Resistance in Bone Metastatic Prostate Cancer Organoids. Int J Mol Sci. 2022 Mar 16; 23(6). Lee S, Mendoza TR, Burner DN, Muldong MT, Wu CCN, Arreola-Villanueva C, Zuniga A, Greenburg O, Zhu WY, Murtadha J, Koutouan E, Pineda N, Pham H, Kang SG, Kim HT, Pineda G, Lennon KM, Cacalano NA, Jamieson CHM, Kane CJ, Kulidjian AA, Gaasterland T, Jamieson CAM. PMID: 35328625; PMCID: PMC8952299.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    2. Establishment and Analysis of Three-Dimensional (3D) Organoids Derived from Patient Prostate Cancer Bone Metastasis Specimens and their Xenografts. J Vis Exp. 2020 02 03; (156). Lee S, Burner DN, Mendoza TR, Muldong MT, Arreola C, Wu CN, Cacalano NA, Kulidjian AA, Kane CJ, Jamieson CAM. PMID: 32065165.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    3. Probiotic-Treated Super-Charged NK Cells Efficiently Clear Poorly Differentiated Pancreatic Tumors in Hu-BLT Mice. Cancers (Basel). 2019 Dec 24; 12(1). Kaur K, Kozlowska AK, Topchyan P, Ko MW, Ohanian N, Chiang J, Cook J, Maung PO, Park SH, Cacalano N, Fang C, Jewett A. PMID: 31878338; PMCID: PMC7017229.
      View in: PubMed   Mentions: 18  
    4. Exosomes: Versatile Nano Mediators of Immune Regulation. Cancers (Basel). 2019 Oct 14; 11(10). Li Q, Wang H, Peng H, Huyan T, Cacalano NA. PMID: 31615107; PMCID: PMC6826959.
      View in: PubMed   Mentions: 59  
    5. Oncogenic Y68 frame shift mutation of PTEN represents a mechanism of docetaxel resistance in endometrial cancer cell lines. Sci Rep. 2019 02 14; 9(1):2111. Zhang H, Wang S, Cacalano N, Zhu H, Liu Q, Xie M, Kamrava M, Konecny G, Jin S. PMID: 30765787; PMCID: PMC6375989.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    6. Complete androgen insensitivity syndrome caused by c.1769-1G > C mutation and activation of a cryptic splice acceptor site in the androgen receptor gene. Steroids. 2018 09; 137:64-69. Wang S, Xia P, Cacalano NA, Xu H, Li D. PMID: 29859233.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    7. Specific bone region localization of osteolytic versus osteoblastic lesions in a patient-derived xenograft model of bone metastatic prostate cancer. Asian J Urol. 2016 Oct; 3(4):229-239. Hirata T, Park SC, Muldong MT, Wu CN, Yamaguchi T, Strasner A, Raheem O, Kumon H, Sah RL, Cacalano NA, Jamieson CHM, Kane CJ, Masuda K, Kulidjian AA, Jamieson CAM. PMID: 29264191; PMCID: PMC5730873.
      View in: PubMed   Mentions: 5  
    8. Resistance to cytotoxicity and sustained release of interleukin-6 and interleukin-8 in the presence of decreased interferon-γ after differentiation of glioblastoma by human natural killer cells. Cancer Immunol Immunother. 2016 09; 65(9):1085-97. Kozlowska AK, Tseng HC, Kaur K, Topchyan P, Inagaki A, Bui VT, Kasahara N, Cacalano N, Jewett A. PMID: 27439500; PMCID: PMC4996719.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    9. Regulation of Natural Killer Cell Function by STAT3. Front Immunol. 2016; 7:128. Cacalano NA. PMID: 27148255; PMCID: PMC4827001.
      View in: PubMed   Mentions: 44     Fields:    
    10. Differential Targeting of Stem Cells and Differentiated Glioblastomas by NK Cells. J Cancer. 2015; 6(9):866-76. Tseng HC, Inagaki A, Bui VT, Cacalano N, Kasahara N, Man YG, Jewett A. PMID: 26284138; PMCID: PMC4532984.
      View in: PubMed   Mentions: 22  
    11. Split anergized Natural Killer cells halt inflammation by inducing stem cell differentiation, resistance to NK cell cytotoxicity and prevention of cytokine and chemokine secretion. Oncotarget. 2015 Apr 20; 6(11):8947-59. Tseng HC, Cacalano N, Jewett A. PMID: 25860927; PMCID: PMC4496194.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    12. Suppressor of cytokine signaling (SOCS) genes are silenced by DNA hypermethylation and histone deacetylation and regulate response to radiotherapy in cervical cancer cells. PLoS One. 2015; 10(4):e0123133. Kim MH, Kim MS, Kim W, Kang MA, Cacalano NA, Kang SB, Shin YJ, Jeong JH. PMID: 25849377; PMCID: PMC4388447.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    13. PCSD1, a new patient-derived model of bone metastatic prostate cancer, is castrate-resistant in the bone-niche. J Transl Med. 2014 Oct 03; 12:275. Godebu E, Muldong M, Strasner A, Wu CN, Park SC, Woo JR, Ma W, Liss MA, Hirata T, Raheem O, Cacalano NA, Kulidjian AA, Jamieson CA. PMID: 25278011; PMCID: PMC4192441.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    14. Induction of Split Anergy Conditions Natural Killer Cells to Promote Differentiation of Stem Cells through Cell-Cell Contact and Secreted Factors. Front Immunol. 2014; 5:269. Tseng HC, Bui V, Man YG, Cacalano N, Jewett A. PMID: 24995006; PMCID: PMC4062968.
      View in: PubMed   Mentions: 40     Fields:    
    15. Natural killer cells as effectors of selection and differentiation of stem cells: role in resolution of inflammation. J Immunotoxicol. 2014 Oct; 11(4):297-307. Jewett A, Man YG, Cacalano N, Kos J, Tseng HC. PMID: 24575813.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    16. Natural killer cells preferentially target cancer stem cells; role of monocytes in protection against NK cell mediated lysis of cancer stem cells. Curr Drug Deliv. 2012 Jan; 9(1):5-16. Jewett A, Tseng HC, Arasteh A, Saadat S, Christensen RE, Cacalano NA. PMID: 22023212.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    17. A novel patient-derived intra-femoral xenograft model of bone metastatic prostate cancer that recapitulates mixed osteolytic and osteoblastic lesions. J Transl Med. 2011 Oct 28; 9:185. Raheem O, Kulidjian AA, Wu C, Jeong YB, Yamaguchi T, Smith KM, Goff D, Leu H, Morris SR, Cacalano NA, Masuda K, Jamieson CH, Kane CJ, Jamieson CA. PMID: 22035283; PMCID: PMC3269442.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    18. The role of aggregation in Fusobacterium nucleatum- induced immune cell death. J Endod. 2011 Nov; 37(11):1531-5. Huynh T, Kapur RV, Kaplan CW, Cacalano N, Kinder Haake S, Shi W, Sieling P, Jewett A. PMID: 22000457.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    19. Differential effect of ionizing radiation exposure on multipotent and differentiation-restricted bone marrow mesenchymal stem cells. J Cell Biochem. 2010 Oct 01; 111(2):322-32. Mussano F, Lee KJ, Zuk P, Tran L, Cacalano NA, Jewett A, Carossa S, Nishimura I. PMID: 20506196.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    20. AID-induced genotoxic stress promotes B cell differentiation in the germinal center via ATM and LKB1 signaling. Mol Cell. 2010 Sep 24; 39(6):873-85. Sherman MH, Kuraishy AI, Deshpande C, Hong JS, Cacalano NA, Gatti RA, Manis JP, Damore MA, Pellegrini M, Teitell MA. PMID: 20864035; PMCID: PMC2945612.
      View in: PubMed   Mentions: 40     Fields:    
    21. Increased lysis of stem cells but not their differentiated cells by natural killer cells; de-differentiation or reprogramming activates NK cells. PLoS One. 2010 Jul 16; 5(7):e11590. Tseng HC, Arasteh A, Paranjpe A, Teruel A, Yang W, Behel A, Alva JA, Walter G, Head C, Ishikawa TO, Herschman HR, Cacalano N, Pyle AD, Park NH, Jewett A. PMID: 20661281; PMCID: PMC2905395.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimalsCells
    22. Strategies to rescue mesenchymal stem cells (MSCs) and dental pulp stem cells (DPSCs) from NK cell mediated cytotoxicity. PLoS One. 2010 Mar 31; 5(3):e9874. Jewett A, Arasteh A, Tseng HC, Behel A, Arasteh H, Yang W, Cacalano NA, Paranjpe A. PMID: 20360990; PMCID: PMC2847602.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    23. Dexamethasone induces dysferlin in myoblasts and enhances their myogenic differentiation. Neuromuscul Disord. 2010 Feb; 20(2):111-21. Belanto JJ, Diaz-Perez SV, Magyar CE, Maxwell MM, Yilmaz Y, Topp K, Boso G, Jamieson CH, Cacalano NA, Jamieson CA. PMID: 20080405; PMCID: PMC2856642.
      View in: PubMed   Mentions: 28     Fields:    
    24. N-acetyl cysteine mediates protection from 2-hydroxyethyl methacrylate induced apoptosis via nuclear factor kappa B-dependent and independent pathways: potential involvement of JNK. Toxicol Sci. 2009 Apr; 108(2):356-66. Paranjpe A, Cacalano NA, Hume WR, Jewett A. PMID: 19176594; PMCID: PMC2664689.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    25. Regulation of IGFBP6 gene and protein is mediated by the inverse expression and function of c-jun N-terminal kinase (JNK) and NFkappaB in a model of oral tumor cells. Apoptosis. 2008 Dec; 13(12):1439-49. Cacalano NA, Le D, Paranjpe A, Wang MY, Fernandez A, Evazyan T, Park NH, Jewett A. PMID: 18982452.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    26. Mechanisms of N-acetyl cysteine-mediated protection from 2-hydroxyethyl methacrylate-induced apoptosis. J Endod. 2008 Oct; 34(10):1191-7. Paranjpe A, Cacalano NA, Hume WR, Jewett A. PMID: 18793918.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    27. SOCS3 regulates p21 expression and cell cycle arrest in response to DNA damage. Cell Signal. 2008 Dec; 20(12):2221-30. Sitko JC, Yeh B, Kim M, Zhou H, Takaesu G, Yoshimura A, McBride WH, Jewett A, Jamieson CA, Cacalano NA. PMID: 18793717; PMCID: PMC2676910.
      View in: PubMed   Mentions: 24     Fields:    
    28. Rapid and potent induction of cell death and loss of NK cell cytotoxicity against oral tumors by F(ab')2 fragment of anti-CD16 antibody. Cancer Immunol Immunother. 2008 Jul; 57(7):1053-66. Jewett A, Teruel A, Romero M, Head C, Cacalano N. PMID: 18188563; PMCID: PMC11030859.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    29. Epidermal growth factor receptor vIII expression in U87 glioblastoma cells alters their proteasome composition, function, and response to irradiation. Mol Cancer Res. 2008 Mar; 6(3):426-34. Kim K, Brush JM, Watson PA, Cacalano NA, Iwamoto KS, McBride WH. PMID: 18337449; PMCID: PMC2877368.
      View in: PubMed   Mentions: 12     Fields:    
    30. Potent induction of TNF-alpha during interaction of immune effectors with oral tumors as a potential mechanism for the loss of NK cell viability and function. Apoptosis. 2007 Nov; 12(11):2063-75. Romero-Reyes M, Head C, Cacalano NA, Jewett A. PMID: 17713857.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    31. Potential contribution of naïve immune effectors to oral tumor resistance: role in synergistic induction of VEGF, IL-6, and IL-8 secretion. Cancer Immunol Immunother. 2008 Mar; 57(3):359-66. Teruel A, Romero M, Cacalano NA, Head C, Jewett A. PMID: 17703300; PMCID: PMC11030830.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    32. N-acetylcysteine protects dental pulp stromal cells from HEMA-induced apoptosis by inducing differentiation of the cells. Free Radic Biol Med. 2007 Nov 15; 43(10):1394-408. Paranjpe A, Cacalano NA, Hume WR, Jewett A. PMID: 17936186; PMCID: PMC2134970.
      View in: PubMed   Mentions: 21     Fields:    
    33. Reciprocal regulation of SOCS 1 and SOCS3 enhances resistance to ionizing radiation in glioblastoma multiforme. Clin Cancer Res. 2007 Apr 15; 13(8):2344-53. Zhou H, Miki R, Eeva M, Fike FM, Seligson D, Yang L, Yoshimura A, Teitell MA, Jamieson CA, Cacalano NA. PMID: 17438093.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    34. HDJ-2 as a target for radiosensitization of glioblastoma multiforme cells by the farnesyltransferase inhibitor R115777 and the role of the p53/p21 pathway. Cancer Res. 2006 Jul 01; 66(13):6756-62. Wang CC, Liao YP, Mischel PS, Iwamoto KS, Cacalano NA, McBride WH. PMID: 16818651.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    35. Coengagement of CD16 and CD94 receptors mediates secretion of chemokines and induces apoptotic death of naive natural killer cells. Clin Cancer Res. 2006 Apr 01; 12(7 Pt 1):1994-2003. Jewett A, Cacalano NA, Head C, Teruel A. PMID: 16609008.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    36. Inhibition of nuclear factor kappa B (NFkappaB) activity in oral tumor cells prevents depletion of NK cells and increases their functional activation. Cancer Immunol Immunother. 2006 Sep; 55(9):1052-63. Jewett A, Cacalano NA, Teruel A, Romero M, Rashedi M, Wang M, Nakamura H. PMID: 16328384; PMCID: PMC11030165.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    37. Cyclooxygenase-2-dependent activation of signal transducer and activator of transcription 3 by interleukin-6 in non-small cell lung cancer. Clin Cancer Res. 2005 Nov 01; 11(21):7674-82. Dalwadi H, Krysan K, Heuze-Vourc'h N, Dohadwala M, Elashoff D, Sharma S, Cacalano N, Lichtenstein A, Dubinett S. PMID: 16278387.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    38. Tyrosine-phosphorylated SOCS3 interacts with the Nck and Crk-L adapter proteins and regulates Nck activation. J Biol Chem. 2004 Sep 03; 279(36):37662-9. Sitko JC, Guevara CI, Cacalano NA. PMID: 15173187.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    39. SOCS-3 regulates onset and maintenance of T(H)2-mediated allergic responses. Nat Med. 2003 Aug; 9(8):1047-54. Seki Y, Inoue H, Nagata N, Hayashi K, Fukuyama S, Matsumoto K, Komine O, Hamano S, Himeno K, Inagaki-Ohara K, Cacalano N, O'Garra A, Oshida T, Saito H, Johnston JA, Yoshimura A, Kubo M. PMID: 12847520.
      View in: PubMed   Mentions: 120     Fields:    Translation:HumansAnimalsCells
    40. Tyrosine phosphorylation disrupts elongin interaction and accelerates SOCS3 degradation. J Biol Chem. 2003 Aug 22; 278(34):31972-9. Haan S, Ferguson P, Sommer U, Hiremath M, McVicar DW, Heinrich PC, Johnston JA, Cacalano NA. PMID: 12783885.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
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