-
A flexible model for thermal performance curves. bioRxiv. 2024 Aug 06.
Cruz-Loya M, Mordecai EA, Savage VM. PMID: 39149255; PMCID: PMC11326125.
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PubMed Mentions:
-
A flexible model for thermal performance curves. bioRxiv. 2024 Aug 06.
Cruz-Loya M, Mordecai EA, Savage VM. PMID: 39149255; PMCID: PMC11326125.
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PubMed Mentions:
-
Multilevel relations among plankton stitched together with an eco-evolutionary needle. Cell Syst. 2024 May 15; 15(5):409-410.
Savage VM. PMID: 38754364.
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PubMed Mentions: Fields:
Translation:
Animals
-
Scaling approaches and macroecology provide a foundation for assessing ecological resilience in the Anthropocene. Philos Trans R Soc Lond B Biol Sci. 2024 May 27; 379(1902):20230010.
Enquist BJ, Erwin D, Savage V, Marquet PA. PMID: 38583479; PMCID: PMC10999275.
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PubMed Mentions: Fields:
-
Evolution Under Thermal Stress Affects Escherichia coli's Resistance to Antibiotics. bioRxiv. 2024 Feb 29.
Bullivant A, Lozano-Huntelman N, Tabibian K, Leung V, Armstrong D, Dudley H, Savage VM, Rodríguez-Verdugo A, Yeh PJ. PMID: 38464198; PMCID: PMC10925296.
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PubMed Mentions:
-
Stimuli-sensitive nano-drug delivery with programmable size changes to enhance accumulation of therapeutic agents in tumors. Drug Deliv. 2023 Dec; 30(1):2186312.
Souri M, Kiani Shahvandi M, Chiani M, Moradi Kashkooli F, Farhangi A, Mehrabi MR, Rahmim A, Savage VM, Soltani M. PMID: 36895188; PMCID: PMC10013474.
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PubMed Mentions:
10 Fields:
Translation:
HumansCells
-
Neuronal branching is increasingly asymmetric near synapses, potentially enabling plasticity while minimizing energy dissipation and conduction time. J R Soc Interface. 2023 09; 20(206):20230265.
Desai-Chowdhry P, Brummer AB, Mallavarapu S, Savage VM. PMID: 37669695; PMCID: PMC10480011.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
-
Neuronal Branching is Increasingly Asymmetric Near Synapses, Potentially Enabling Plasticity While Minimizing Energy Dissipation and Conduction Time. bioRxiv. 2023 May 21.
Desai-Chowdhry P, Brummer AB, Mallavarapu S, Savage VM. PMID: 37292687; PMCID: PMC10245708.
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PubMed Mentions:
-
Meta-analysis of three-stressor combinations on population-level fitness reveal substantial higher-order interactions. Sci Total Environ. 2023 Mar 15; 864:161163.
Diamant ES, Boyd S, Lozano-Huntelman NA, Enriquez V, Kim AR, Savage VM, Yeh PJ. PMID: 36572303.
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PubMed Mentions: Fields:
-
How axon and dendrite branching are guided by time, energy, and spatial constraints. Sci Rep. 2022 12 02; 12(1):20810.
Desai-Chowdhry P, Brummer AB, Savage VM. PMID: 36460669; PMCID: PMC9718790.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
-
Evolution of antibiotic resistance impacts optimal temperature and growth rate in Escherichia coli and Staphylococcus epidermidis. J Appl Microbiol. 2022 Oct; 133(4):2655-2667.
Mira P, Lozano-Huntelman N, Johnson A, Savage VM, Yeh P. PMID: 36070219.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
-
Correction: Detecting the impact of temperature on transmission of Zika, dengue, and chikungunya using mechanistic models. PLoS Negl Trop Dis. 2022 Jun; 16(6):e0010514.
Mordecai EA, Cohen JM, Evans MV, Gudapati P, Johnson LR, Lippi CA, Miazgowicz K, Murdock CC, Rohr JR, Ryan SJ, Savage V, Shocket MS, Ibarra AS, Thomas MB, Weikel DP. PMID: 35653363; PMCID: PMC9162309.
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PubMed Mentions: Fields:
-
Correction: Detecting the impact of temperature on transmission of Zika, dengue, and chikungunya using mechanistic models. PLoS Negl Trop Dis. 2022 Jun; 16(6):e0010514.
Mordecai EA, Cohen JM, Evans MV, Gudapati P, Johnson LR, Lippi CA, Miazgowicz K, Murdock CC, Rohr JR, Ryan SJ, Savage V, Shocket MS, Ibarra AS, Thomas MB, Weikel DP. PMID: 35653363; PMCID: PMC9162309.
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PubMed Mentions: Fields:
-
Antibiotics Shift the Temperature Response Curve of Escherichia coli Growth. mSystems. 2021 Aug 31; 6(4):e0022821.
Cruz-Loya M, Tekin E, Kang TM, Cardona N, Lozano-Huntelman N, Rodriguez-Verdugo A, Savage VM, Yeh PJ. PMID: 34282938; PMCID: PMC8422994.
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PubMed Mentions:
9 Fields:
-
The allometry of locomotion. Ecology. 2021 07; 102(7):e03369.
Cloyed CS, Grady JM, Savage VM, Uyeda JC, Dell AI. PMID: 33864262.
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PubMed Mentions:
10 Fields:
Translation:
Animals
-
Hidden suppressive interactions are common in higher-order drug combinations. iScience. 2021 Apr 23; 24(4):102355.
Lozano-Huntelman NA, Zhou A, Tekin E, Cruz-Loya M, Østman B, Boyd S, Savage VM, Yeh P. PMID: 33870144; PMCID: PMC8044428.
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PubMed Mentions:
2
-
Branching principles of animal and plant networks identified by combining extensive data, machine learning and modelling. J R Soc Interface. 2021 01; 18(174):20200624.
Brummer AB, Lymperopoulos P, Shen J, Tekin E, Bentley LP, Buzzard V, Gray A, Oliveras I, Enquist BJ, Savage VM. PMID: 33402023; PMCID: PMC7879751.
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PubMed Mentions:
4 Fields:
Translation:
Animals
-
Improving Blood Vessel Tortuosity Measurements via Highly Sampled Numerical Integration of the Frenet-Serret Equations. IEEE Trans Med Imaging. 2021 01; 40(1):297-309.
Brummer AB, Hunt D, Savage V. PMID: 32956050.
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PubMed Mentions:
1 Fields:
Translation:
Humans
-
Stability of ecosystems enhanced by species-interaction constraints. Phys Rev E. 2020 Dec; 102(6-1):062405.
Pettersson S, Savage VM, Jacobi MN. PMID: 33465982.
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PubMed Mentions:
2 Fields:
-
Unraveling why we sleep: Quantitative analysis reveals abrupt transition from neural reorganization to repair in early development. Sci Adv. 2020 09; 6(38).
Cao J, Herman AB, West GB, Poe G, Savage VM. PMID: 32948580; PMCID: PMC7500925.
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PubMed Mentions:
31 Fields:
-
Quantifying antibody kinetics and RNA detection during early-phase SARS-CoV-2 infection by time since symptom onset. Elife. 2020 09 07; 9.
Borremans B, Gamble A, Prager KC, Helman SK, McClain AM, Cox C, Savage V, Lloyd-Smith JO. PMID: 32894217; PMCID: PMC7508557.
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PubMed Mentions:
51 Fields:
Translation:
HumansCellsPHPublic Health
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Using a newly introduced framework to measure ecological stressor interactions. Ecol Lett. 2020 Sep; 23(9):1391-1403.
Tekin E, Diamant ES, Cruz-Loya M, Enriquez V, Singh N, Savage VM, Yeh PJ. PMID: 32627356.
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PubMed Mentions:
13 Fields:
-
Predicting collapse of complex ecological systems: quantifying the stability-complexity continuum. J R Soc Interface. 2020 05; 17(166):20190391.
Pettersson S, Savage VM, Nilsson Jacobi M. PMID: 32396810; PMCID: PMC7276551.
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PubMed Mentions:
4 Fields:
-
Compounding Effects of Climate Warming and Antibiotic Resistance. iScience. 2020 Apr 24; 23(4):101024.
Rodríguez-Verdugo A, Lozano-Huntelman N, Cruz-Loya M, Savage V, Yeh P. PMID: 32299057; PMCID: PMC7160571.
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PubMed Mentions:
25
-
Informing trait-based ecology by assessing remotely sensed functional diversity across a broad tropical temperature gradient. Sci Adv. 2019 12; 5(12):eaaw8114.
Durán SM, Martin RE, Díaz S, Maitner BS, Malhi Y, Salinas N, Shenkin A, Silman MR, Wieczynski DJ, Asner GP, Bentley LP, Savage VM, Enquist BJ. PMID: 31840057; PMCID: PMC6892629.
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PubMed Mentions:
5 Fields:
-
Novelist Cormac McCarthy's tips on how to write a great science paper. Nature. 2019 10; 574(7778):441-442.
Savage V, Yeh P. PMID: 31611681.
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PubMed Mentions:
1 Fields:
-
Thermal biology of mosquito-borne disease. Ecol Lett. 2019 Oct; 22(10):1690-1708.
Mordecai EA, Caldwell JM, Grossman MK, Lippi CA, Johnson LR, Neira M, Rohr JR, Ryan SJ, Savage V, Shocket MS, Sippy R, Stewart Ibarra AM, Thomas MB, Villena O. PMID: 31286630; PMCID: PMC6744319.
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PubMed Mentions:
198 Fields:
Translation:
AnimalsCellsPHPublic Health
-
Self-Similar Processes Follow a Power Law in Discrete Logarithmic Space. Phys Rev Lett. 2019 Apr 19; 122(15):158303.
Newberry MG, Savage VM. PMID: 31050532.
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PubMed Mentions:
2 Fields:
-
Climate shapes and shifts functional biodiversity in forests worldwide. Proc Natl Acad Sci U S A. 2019 01 08; 116(2):587-592.
Wieczynski DJ, Boyle B, Buzzard V, Duran SM, Henderson AN, Hulshof CM, Kerkhoff AJ, McCarthy MC, Michaletz ST, Swenson NG, Asner GP, Bentley LP, Enquist BJ, Savage VM. PMID: 30584087; PMCID: PMC6329988.
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PubMed Mentions:
31 Fields:
-
Social tipping points in animal societies. Proc Biol Sci. 2018 09 19; 285(1887).
Pruitt JN, Berdahl A, Riehl C, Pinter-Wollman N, Moeller HV, Pringle EG, Aplin LM, Robinson EJH, Grilli J, Yeh P, Savage VM, Price MH, Garland J, Gilby IC, Crofoot MC, Doering GN, Hobson EA. PMID: 30232162; PMCID: PMC6170811.
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PubMed Mentions:
16 Fields:
Translation:
Animals
-
Prevalence and patterns of higher-order drug interactions in Escherichia coli. NPJ Syst Biol Appl. 2018; 4:31.
Tekin E, White C, Kang TM, Singh N, Cruz-Loya M, Damoiseaux R, Savage VM, Yeh PJ. PMID: 30181902; PMCID: PMC6119685.
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PubMed Mentions:
39 Fields:
-
Stressor interaction networks suggest antibiotic resistance co-opted from stress responses to temperature. ISME J. 2019 01; 13(1):12-23.
Cruz-Loya M, Kang TM, Lozano NA, Watanabe R, Tekin E, Damoiseaux R, Savage VM, Yeh PJ. PMID: 30171253; PMCID: PMC6298959.
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PubMed Mentions:
26 Fields:
Translation:
Cells
-
Intermediate Levels of Antibiotics May Increase Diversity of Colony Size Phenotype in Bacteria. Comput Struct Biotechnol J. 2018; 16:307-315.
Lee L, Savage VM, Yeh PJ. PMID: 30214695; PMCID: PMC6134325.
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PubMed Mentions:
8
-
Optimal occlusion uniformly partitions red blood cells fluxes within a microvascular network. PLoS Comput Biol. 2017 12; 13(12):e1005892.
Chang SS, Tu S, Baek KI, Pietersen A, Liu YH, Savage VM, Hwang SL, Hsiai TK, Roper M. PMID: 29244812; PMCID: PMC5747476.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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When more is less: Emergent suppressive interactions in three-drug combinations. BMC Microbiol. 2017 05 06; 17(1):107.
Beppler C, Tekin E, White C, Mao Z, Miller JH, Damoiseaux R, Savage VM, Yeh PJ. PMID: 28477626; PMCID: PMC5420147.
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PubMed Mentions:
13 Fields:
Translation:
Cells
-
Detecting the impact of temperature on transmission of Zika, dengue, and chikungunya using mechanistic models. PLoS Negl Trop Dis. 2017 04; 11(4):e0005568.
Mordecai EA, Cohen JM, Evans MV, Gudapati P, Johnson LR, Lippi CA, Miazgowicz K, Murdock CC, Rohr JR, Ryan SJ, Savage V, Shocket MS, Stewart Ibarra A, Thomas MB, Weikel DP. PMID: 28448507; PMCID: PMC5423694.
View in:
PubMed Mentions:
215 Fields:
Translation:
HumansAnimalsPHPublic Health
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A general model for metabolic scaling in self-similar asymmetric networks. PLoS Comput Biol. 2017 03; 13(3):e1005394.
Brummer AB, Savage VM, Enquist BJ. PMID: 28319153; PMCID: PMC5378416.
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PubMed Mentions:
11 Fields:
Translation:
Cells
-
Uncovering emergent interactions in three-way combinations of stressors. J R Soc Interface. 2016 12; 13(125).
Beppler C, Tekin E, Mao Z, White C, McDiarmid C, Vargas E, Miller JH, Savage VM, Yeh PJ. PMID: 27974577; PMCID: PMC5221529.
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PubMed Mentions:
21 Fields:
Translation:
Cells
-
Do Vascular Networks Branch Optimally or Randomly across Spatial Scales? PLoS Comput Biol. 2016 Nov; 12(11):e1005223.
Tekin E, Hunt D, Newberry MG, Savage VM. PMID: 27902691; PMCID: PMC5130167.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimals
-
Asymmetries arising from the space-filling nature of vascular networks. Phys Rev E. 2016 06; 93(6):062305.
Hunt D, Savage VM. PMID: 27415278.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
-
Enhanced identification of synergistic and antagonistic emergent interactions among three or more drugs. J R Soc Interface. 2016 06; 13(119).
Tekin E, Beppler C, White C, Mao Z, Savage VM, Yeh PJ. PMID: 27278366; PMCID: PMC4938094.
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PubMed Mentions:
24 Fields:
Translation:
Cells
-
Real versus Artificial Variation in the Thermal Sensitivity of Biological Traits. Am Nat. 2016 Feb; 187(2):E41-52.
Pawar S, Dell AI, Savage VM, Knies JL. PMID: 26731029.
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PubMed Mentions:
23 Fields:
Translation:
Animals
-
Testing Foundations of Biological Scaling Theory Using Automated Measurements of Vascular Networks. PLoS Comput Biol. 2015 Aug; 11(8):e1004455.
Newberry MG, Ennis DB, Savage VM. PMID: 26317654; PMCID: PMC4552567.
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PubMed Mentions:
14 Fields:
Translation:
Humans
-
The body size dependence of trophic cascades. Am Nat. 2015 Mar; 185(3):354-66.
DeLong JP, Gilbert B, Shurin JB, Savage VM, Barton BT, Clements CF, Dell AI, Greig HS, Harley CD, Kratina P, McCann KS, Tunney TD, Vasseur DA, O'Connor MI. PMID: 25674690.
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PubMed Mentions:
32 Fields:
Translation:
Animals
-
A bioenergetic framework for the temperature dependence of trophic interactions. Ecol Lett. 2014 Aug; 17(8):902-14.
Gilbert B, Tunney TD, McCann KS, DeLong JP, Vasseur DA, Savage V, Shurin JB, Dell AI, Barton BT, Harley CD, Kharouba HM, Kratina P, Blanchard JL, Clements C, Winder M, Greig HS, O'Connor MI. PMID: 24894409.
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PubMed Mentions:
52 Fields:
Translation:
Animals
-
Increased temperature variation poses a greater risk to species than climate warming. Proc Biol Sci. 2014 Mar 22; 281(1779):20132612.
Vasseur DA, DeLong JP, Gilbert B, Greig HS, Harley CD, McCann KS, Savage V, Tunney TD, O'Connor MI. PMID: 24478296; PMCID: PMC3924069.
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PubMed Mentions:
192 Fields:
Translation:
Animals
-
Deviation from symmetrically self-similar branching in trees predicts altered hydraulics, mechanics, light interception and metabolic scaling. New Phytol. 2014 Jan; 201(1):217-229.
Smith DD, Sperry JS, Enquist BJ, Savage VM, McCulloh KA, Bentley LP. PMID: 24102299.
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PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
-
An empirical assessment of tree branching networks and implications for plant allometric scaling models. Ecol Lett. 2013 Aug; 16(8):1069-78.
Bentley LP, Stegen JC, Savage VM, Smith DD, von Allmen EI, Sperry JS, Reich PB, Enquist BJ. PMID: 23800188.
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PubMed Mentions:
27 Fields:
Translation:
Animals
-
Using Fractal Geometry and Universal Growth Curves as Diagnostics for Comparing Tumor Vasculature and Metabolic Rate With Healthy Tissue and for Predicting Responses to Drug Therapies. Discrete Continuous Dyn Syst Ser B. 2013 Jun; 18(4).
Savage VM, Herman AB, West GB, Leu K. PMID: 24204201; PMCID: PMC3817925.
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PubMed Mentions:
5
-
Temperature dependence of trophic interactions are driven by asymmetry of species responses and foraging strategy. J Anim Ecol. 2014 Jan; 83(1):70-84.
Dell AI, Pawar S, Savage VM. PMID: 23692182.
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PubMed Mentions:
91 Fields:
Translation:
Animals
-
Testing the metabolic theory of ecology. Ecol Lett. 2012 Dec; 15(12):1465-74.
Price CA, Weitz JS, Savage VM, Stegen J, Clarke A, Coomes DA, Dodds PS, Etienne RS, Kerkhoff AJ, McCulloh K, Niklas KJ, Olff H, Swenson NG, Chave J. PMID: 22931542.
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PubMed Mentions:
46 Fields:
Translation:
Animals
-
Dimensionality of consumer search space drives trophic interaction strengths. Nature. 2012 Jun 28; 486(7404):485-9.
Pawar S, Dell AI, Savage VM. PMID: 22722834.
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PubMed Mentions:
52 Fields:
Translation:
Animals
-
A framework for elucidating the temperature dependence of fitness. Am Nat. 2012 Feb; 179(2):178-91.
Amarasekare P, Savage V. PMID: 22218308.
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PubMed Mentions:
49 Fields:
Translation:
Animals
-
A quantitative theory of solid tumor growth, metabolic rate and vascularization. PLoS One. 2011; 6(9):e22973.
Herman AB, Savage VM, West GB. PMID: 21980335; PMCID: PMC3182997.
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PubMed Mentions:
35 Fields:
Translation:
HumansAnimals
-
Systematic variation in the temperature dependence of physiological and ecological traits. Proc Natl Acad Sci U S A. 2011 Jun 28; 108(26):10591-6.
Dell AI, Pawar S, Savage VM. PMID: 21606358; PMCID: PMC3127911.
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PubMed Mentions:
214 Fields:
Translation:
Animals
-
Curvature in metabolic scaling: a reply to MacKay. J Theor Biol. 2011 Jul 07; 280(1):197-8.
Deeds EJ, Savage V, Fontana W. PMID: 21497609.
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PubMed Mentions:
2 Fields:
-
Hydraulic trade-offs and space filling enable better predictions of vascular structure and function in plants. Proc Natl Acad Sci U S A. 2010 Dec 28; 107(52):22722-7.
Savage VM, Bentley LP, Enquist BJ, Sperry JS, Smith DD, Reich PB, von Allmen EI. PMID: 21149696; PMCID: PMC3012458.
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PubMed Mentions:
44 Fields:
Translation:
Animals
-
Sizing up allometric scaling theory. PLoS Comput Biol. 2008 Sep 12; 4(9):e1000171.
Savage VM, Deeds EJ, Fontana W. PMID: 18787686; PMCID: PMC2518954.
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PubMed Mentions:
67 Fields:
Translation:
Animals
-
Comment on 'A critical understanding of the fractal model of metabolic scaling'. J Exp Biol. 2007 Nov; 210(Pt 21):3873-4; author reply 3875-6.
Savage VM, Enquist BJ, West GB. PMID: 17951428.
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PubMed Mentions:
4 Fields:
-
A general model for allometric covariation in botanical form and function. Proc Natl Acad Sci U S A. 2007 Aug 07; 104(32):13204-9.
Price CA, Enquist BJ, Savage VM. PMID: 17664421; PMCID: PMC1941814.
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PubMed Mentions:
39 Fields:
Translation:
Animals
-
Setting the absolute tempo of biodiversity dynamics. Ecol Lett. 2007 Jul; 10(7):637-46.
Allen AP, Savage VM. PMID: 17542942.
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PubMed Mentions:
13 Fields:
Translation:
Animals
-
A general multi-trait-based framework for studying the effects of biodiversity on ecosystem functioning. J Theor Biol. 2007 Jul 21; 247(2):213-29.
Savage VM, Webb CT, Norberg J. PMID: 17448502; PMCID: PMC2041898.
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PubMed Mentions:
17 Fields:
Translation:
Animals
-
Scaling of number, size, and metabolic rate of cells with body size in mammals. Proc Natl Acad Sci U S A. 2007 Mar 13; 104(11):4718-23.
Savage VM, Allen AP, Brown JH, Gillooly JF, Herman AB, Woodruff WH, West GB. PMID: 17360590; PMCID: PMC1838666.
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PubMed Mentions:
89 Fields:
Translation:
HumansAnimalsCells
-
A quantitative, theoretical framework for understanding mammalian sleep. Proc Natl Acad Sci U S A. 2007 Jan 16; 104(3):1051-6.
Savage VM, West GB. PMID: 17215372; PMCID: PMC1783362.
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PubMed Mentions:
29 Fields:
Translation:
Animals
-
Kinetic effects of temperature on rates of genetic divergence and speciation. Proc Natl Acad Sci U S A. 2006 Jun 13; 103(24):9130-5.
Allen AP, Gillooly JF, Savage VM, Brown JH. PMID: 16754845; PMCID: PMC1474011.
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PubMed Mentions:
99 Fields:
Translation:
Animals
-
Comment on "The illusion of invariant quantities in life histories". Science. 2006 Apr 14; 312(5771):198; author reply 198.
Savage VM, White EP, Moses ME, Ernest SK, Enquist BJ, Charnov EL. PMID: 16614200.
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PubMed Mentions:
4 Fields:
Translation:
Animals
-
The metabolic basis of whole-organism RNA and phosphorus content. Proc Natl Acad Sci U S A. 2005 Aug 16; 102(33):11923-7.
Gillooly JF, Allen AP, Brown JH, Elser JJ, Martinez del Rio C, Savage VM, West GB, Woodruff WH, Woods HA. PMID: 16091465; PMCID: PMC1187991.
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PubMed Mentions:
31 Fields:
Translation:
Animals
-
Body sizes of hosts and parasitoids in individual feeding relationships. Proc Natl Acad Sci U S A. 2005 Jan 18; 102(3):684-9.
Cohen JE, Jonsson T, Müller CB, Godfray HC, Savage VM. PMID: 15647346; PMCID: PMC545575.
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PubMed Mentions:
21 Fields:
Translation:
Animals
-
Improved approximations to scaling relationships for species, populations, and ecosystems across latitudinal and elevational gradients. J Theor Biol. 2004 Apr 21; 227(4):525-34.
Savage VM. PMID: 15038987.
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PubMed Mentions:
21 Fields:
Translation:
Animals
-
Effects of body size and temperature on population growth. Am Nat. 2004 Mar; 163(3):429-41.
Savage VM, Gilloly JF, Brown JH, Charnov EL. PMID: 15026978.
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PubMed Mentions:
189 Fields:
Translation:
Animals
-
Physiology: Why does metabolic rate scale with body size? Nature. 2003 Feb 13; 421(6924):713; discussion 714.
West GB, Savage VM, Gillooly J, Enquist BJ, Woodruff WH, Brown JH. PMID: 12610614.
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PubMed Mentions:
22 Fields:
Translation:
Animals
-
Effects of size and temperature on developmental time. Nature. 2002 May 02; 417(6884):70-3.
Gillooly JF, Charnov EL, West GB, Savage VM, Brown JH. PMID: 11986667.
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PubMed Mentions:
163 Fields:
Translation:
Animals