Harry B Rossiter

Title(s)Professor-in-Residence, Medicine
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    1. Dynamic airway function during exercise in COPD assessed via impulse oscillometry before and after inhaled bronchodilators. J Appl Physiol (1985). 2021 05 20. Tiller NB, Cao M, Lin F, Yuan W, Wang CY, Abbasi A, Calmelat R, Soriano A, Rossiter HB, Casaburi R, Stringer WW, Porszasz J. PMID: 34013748.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. The "Anaerobic Threshold" Concept Is Valid in Physiology and Medicine. Med Sci Sports Exerc. 2021 May 01; 53(5):1089-1092. Rossiter HB. PMID: 33844670.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. The effect of long-acting dual bronchodilator therapy on exercise tolerance, dynamic hyperinflation, and dead space during constant work rate exercise in COPD. J Appl Physiol (1985). 2021 06 01; 130(6):2009-2018. Stringer WW, Porszasz J, Cao M, Rossiter HB, Siddiqui S, Rennard S, Casaburi R. PMID: 33914661.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Reply from George A. Brooks, Harry B. Rossiter, David C. Poole and L. Bruce Gladden. J Physiol. 2021 03; 599(5):1711-1712. Brooks GA, Rossiter HB, Poole DC, Gladden LB. PMID: 33507565.
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    5. Reply from David Poole, Harry Rossiter, George Brooks and L. Bruce Gladden. J Physiol. 2021 03; 599(5):1715-1716. Poole DC, Rossiter HB, Brooks GA, Gladden LB. PMID: 33450047.
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    6. Transcutaneous PCO2 for Exercise Gas Exchange Efficiency in Chronic Obstructive Pulmonary Disease. COPD. 2021 Feb; 18(1):16-25. Cao M, Stringer WW, Corey S, Orogian A, Cao R, Calmelat R, Lin F, Casaburi R, Rossiter HB, Porszasz J. PMID: 33455452.
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    7. Serum Acylglycerols Inversely Associate with Muscle Oxidative Capacity in Severe COPD. Med Sci Sports Exerc. 2021 01; 53(1):10-18. Li R, Adami A, Chang CC, Tseng CH, Hsiai TK, Rossiter HB. PMID: 32694368.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    8. The anaerobic threshold: 50+ years of controversy. J Physiol. 2021 02; 599(3):737-767. Poole DC, Rossiter HB, Brooks GA, Gladden LB. PMID: 33112439.
      View in: PubMed   Mentions: 10     Fields:    
    9. Muscle Oxidative Capacity Is Reduced in Both Upper and Lower Limbs in COPD. Med Sci Sports Exerc. 2020 10; 52(10):2061-2068. Adami A, Corvino RB, Calmelat RA, Porszasz J, Casaburi R, Rossiter HB. PMID: 32282451.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    10. Speeding of oxygen uptake kinetics is not different following low-intensity blood-flow-restricted and high-intensity interval training. Exp Physiol. 2019 12; 104(12):1858-1867. Corvino RB, Oliveira MFM, Denadai BS, Rossiter HB, Caputo F. PMID: 31613029.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Reply: Carbon Dioxide Narcosis or Sleep Deprivation? Ann Am Thorac Soc. 2019 06; 16(6):778. Lanks CW, Sue DY, Rossiter HB. PMID: 30916987.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. Tissue-specific dysregulation of mitochondrial respiratory capacity and coupling control in colon-26 tumor-induced cachexia. . 2019 07 01; 317(1):R68-R82. Halle JL, Pena GS, Paez HG, Castro AJ, Rossiter HB, Visavadiya NP, Whitehurst MA, Khamoui AV. PMID: 31017805.
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    13. A Pickwickian Problem: How Is Breathing Controlled? Ann Am Thorac Soc. 2019 01; 16(1):138-143. Lanks CW, Sue DY, Rossiter HB. PMID: 30592453.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    14. Genetic variants predicting aerobic capacity response to training are also associated with skeletal muscle oxidative capacity in moderate-to-severe COPD. Physiol Genomics. 2018 09 01; 50(9):688-690. Adami A, Hobbs BD, McDonald MN, Casaburi R, Rossiter HB, COPDGene Investigators . PMID: 29799805.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    15. Slow V?O2 kinetics in acute hypoxia are not related to a hyperventilation-induced hypocapnia. Respir Physiol Neurobiol. 2018 05; 251:41-49. Keir DA, Pollock M, Thuraisingam P, Paterson DH, Heigenhauser GJF, Rossiter HB, Kowalchuk JM. PMID: 29477729.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. Effect of tiotropium on spontaneous expiratory flow-volume curves during exercise in GOLD 1-2 COPD. Respir Physiol Neurobiol. 2018 05; 251:8-15. Porszasz J, Carraro N, Cao R, Gore A, Ma S, Jiang T, Maltais F, Ferguson GT, O'Donnell DE, Shaikh A, Rossiter HB, Casaburi R. PMID: 29438808.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    17. Last Word on Viewpoint: Principles, insights, and potential pitfalls of the noninvasive determination of muscle oxidative capacity by near-infrared spectroscopy. J Appl Physiol (1985). 2018 01 01; 124(1):256. Adami A, Rossiter HB. PMID: 29364791.
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    18. Reply to Francescato et al.: Interpreting the averaging methods to estimate oxygen uptake kinetics parameters. J Appl Physiol (1985). 2017 10 01; 123(4):1019. Benson AP, Bowen TS, Ferguson C, Murgatroyd SR, Rossiter HB. PMID: 29074573.
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    19. Dissociating external power from intramuscular exercise intensity during intermittent bilateral knee-extension in humans. J Physiol. 2017 11 01; 595(21):6673-6686. Davies MJ, Benson AP, Cannon DT, Marwood S, Kemp GJ, Rossiter HB, Ferguson C. PMID: 28776675.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    20. Principles, insights, and potential pitfalls of the noninvasive determination of muscle oxidative capacity by near-infrared spectroscopy. J Appl Physiol (1985). 2018 01 01; 124(1):245-248. Adami A, Rossiter HB. PMID: 28684592.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    21. Giants in Chest Medicine: Karlman Wasserman, MD, PhD, FCCP. Chest. 2017 06; 151(6):1209-1212. Kisaka T, Dumitrescu D, Rossiter HB, Sietsema KE. PMID: 28599928.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    22. Data collection, handling, and fitting strategies to optimize accuracy and precision of oxygen uptake kinetics estimation from breath-by-breath measurements. J Appl Physiol (1985). 2017 Jul 01; 123(1):227-242. Benson AP, Bowen TS, Ferguson C, Murgatroyd SR, Rossiter HB. PMID: 28450551.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    23. Physiological responses to interval endurance exercise at different levels of blood flow restriction. Eur J Appl Physiol. 2017 Jan; 117(1):39-52. Corvino RB, Rossiter HB, Loch T, Martins JC, Caputo F. PMID: 27826654.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    24. Critical Power: An Important Fatigue Threshold in Exercise Physiology. Med Sci Sports Exerc. 2016 11; 48(11):2320-2334. Poole DC, Burnley M, Vanhatalo A, Rossiter HB, Jones AM. PMID: 27031742.
      View in: PubMed   Mentions: 61     Fields:    Translation:Humans
    25. Exercise, ageing and the lung. Eur Respir J. 2016 11; 48(5):1471-1486. Roman MA, Rossiter HB, Casaburi R. PMID: 27799391.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    26. Effect of heavy-intensity 'priming' exercise on oxygen uptake and muscle deoxygenation kinetics during moderate-intensity step-transitions initiated from an elevated work rate. Respir Physiol Neurobiol. 2017 01; 235:62-70. Nederveen JP, Keir DA, Love LK, Rossiter HB, Kowalchuk JM. PMID: 27693390.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    27. Skeletal muscle power and fatigue at the tolerable limit of ramp-incremental exercise in COPD. J Appl Physiol (1985). 2016 12 01; 121(6):1365-1373. Cannon DT, Coelho AC, Cao R, Cheng A, Porszasz J, Casaburi R, Rossiter HB. PMID: 27660300.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    28. Reproducibility of NIRS assessment of muscle oxidative capacity in smokers with and without COPD. Respir Physiol Neurobiol. 2017 01; 235:18-26. Adami A, Cao R, Porszasz J, Casaburi R, Rossiter HB. PMID: 27659351.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    29. Hormesis, mithridatism and Paracelsus: A little oxidative stress goes a long way. Hypertens Res. 2017 01; 40(1):29-30. Stringer WW, Rossiter HB. PMID: 27511052.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    30. A Novel Spirometric Measure Identifies Mild COPD Unidentified by Standard Criteria. Chest. 2016 Nov; 150(5):1080-1090. Dilektasli AG, Porszasz J, Casaburi R, Stringer WW, Bhatt SP, Pak Y, Rossiter HB, Washko G, Castaldi PJ, Estepar RSJ, Hansen JE, COPDGene investigators . PMID: 27452770.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    31. Impaired Lung Mitochondrial Respiration Following Perinatal Nicotine Exposure in Rats. Lung. 2016 Apr; 194(2):325-8. Cannon DT, Liu J, Sakurai R, Rossiter HB, Rehan VK. PMID: 26899624.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCellsPHPublic Health
    32. The influence of metabolic and circulatory heterogeneity on the expression of pulmonary oxygen uptake kinetics in humans. Exp Physiol. 2016 Jan; 101(1):176-92. Keir DA, Robertson TC, Benson AP, Rossiter HB, Kowalchuk JM. PMID: 26537768.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    33. The Spatial Distribution of Absolute Skeletal Muscle Deoxygenation During Ramp-Incremental Exercise Is Not Influenced by Hypoxia. Adv Exp Med Biol. 2016; 876:19-26. Bowen TS, Koga S, Amano T, Kondo N, Rossiter HB. PMID: 26782190.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    34. Influence of muscle metabolic heterogeneity in determining the V?o2p kinetic response to ramp-incremental exercise. J Appl Physiol (1985). 2016 Mar 01; 120(5):503-13. Keir DA, Benson AP, Love LK, Robertson TC, Rossiter HB, Kowalchuk JM. PMID: 26679614.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    35. Each-step activation of oxidative phosphorylation is necessary to explain muscle metabolic kinetic responses to exercise and recovery in humans. J Physiol. 2015 Dec 15; 593(24):5255-68. Korzeniewski B, Rossiter HB. PMID: 26503399.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    36. MRS Evidence of Adequate O2 Supply in Human Skeletal Muscle at the Onset of Exercise. Med Sci Sports Exerc. 2015 Nov; 47(11):2299-307. Richardson RS, Wary C, Wray DW, Hoff J, Rossiter HB, Layec G, Carlier PG. PMID: 25830362.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    37. Response. Med Sci Sports Exerc. 2015 Nov; 47(11):2481-2. Richardson RS, Wary C, Wray DW, Hoff J, Rossiter HB, Layec G, Carlier PG. PMID: 26473761.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    38. Validation of a high-power, time-resolved, near-infrared spectroscopy system for measurement of superficial and deep muscle deoxygenation during exercise. J Appl Physiol (1985). 2015 Jun 01; 118(11):1435-42. Koga S, Barstow TJ, Okushima D, Rossiter HB, Kondo N, Ohmae E, Poole DC. PMID: 25840439.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCTClinical Trials
    39. Skeletal muscle fatigue and decreased efficiency: two sides of the same coin? Exerc Sport Sci Rev. 2015 Apr; 43(2):75-83. Grassi B, Rossiter HB, Zoladz JA. PMID: 25688762.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    40. Exercise oscillatory ventilation: ventilation-perfusion abnormality in heart failure. Int J Cardiol. 2015 Apr 15; 185:55. Kisaka T, Rossiter HB, Wasserman K, Kihara Y. PMID: 25804348.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    41. Changes in whole tissue heme concentration dissociates muscle deoxygenation from muscle oxygen extraction during passive head-up tilt. J Appl Physiol (1985). 2015 May 01; 118(9):1091-9. Adami A, Koga S, Kondo N, Cannon DT, Kowalchuk JM, Amano T, Rossiter HB. PMID: 25678700.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    42. Differential regulation of perineuronal nets in the brain and spinal cord with exercise training. Brain Res Bull. 2015 Feb; 111:20-6. Smith CC, Mauricio R, Nobre L, Marsh B, Wüst RC, Rossiter HB, Ichiyama RM. PMID: 25526898.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    43. Skeletal muscle ATP turnover by 31P magnetic resonance spectroscopy during moderate and heavy bilateral knee extension. J Physiol. 2014 Dec 01; 592(23):5287-300. Cannon DT, Bimson WE, Hampson SA, Bowen TS, Murgatroyd SR, Marwood S, Kemp GJ, Rossiter HB. PMID: 25281731.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    44. Slowed muscle oxygen uptake kinetics with raised metabolism are not dependent on blood flow or recruitment dynamics. J Physiol. 2014 Apr 15; 592(8):1857-71. Wüst RC, McDonald JR, Sun Y, Ferguson BS, Rogatzki MJ, Spires J, Kowalchuk JM, Gladden LB, Rossiter HB. PMID: 24469073.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    45. Dynamic heterogeneity of exercising muscle blood flow and O2 utilization. Med Sci Sports Exerc. 2014; 46(5):860-76. Koga S, Rossiter HB, Heinonen I, Musch TI, Poole DC. PMID: 24091989.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    46. Slowed oxygen uptake kinetics in hypoxia correlate with the transient peak and reduced spatial distribution of absolute skeletal muscle deoxygenation. Exp Physiol. 2013 Nov; 98(11):1585-96. Bowen TS, Rossiter HB, Benson AP, Amano T, Kondo N, Kowalchuk JM, Koga S. PMID: 23851917.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    47. Muscle metabolism and activation heterogeneity by combined 31P chemical shift and T2 imaging, and pulmonary O2 uptake during incremental knee-extensor exercise. J Appl Physiol (1985). 2013 Sep; 115(6):839-49. Cannon DT, Howe FA, Whipp BJ, Ward SA, McIntyre DJ, Ladroue C, Griffiths JR, Kemp GJ, Rossiter HB. PMID: 23813534.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    48. A validated model of oxygen uptake and circulatory dynamic interactions at exercise onset in humans. J Appl Physiol (1985). 2013 Sep 01; 115(5):743-55. Benson AP, Grassi B, Rossiter HB. PMID: 23766506.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    49. An (un)paralleled process? Exp Physiol. 2013 Apr; 98(4):881. Rossiter HB. PMID: 23520341.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    50. Professor Brian J. Whipp: an obituary. Eur J Appl Physiol. 2013 Apr; 113(4):1099-100. Fukuba Y, Kowalchuk JM, Rossiter HB. PMID: 23385655.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    51. Sinusoidal high-intensity exercise does not elicit ventilatory limitation in chronic obstructive pulmonary disease. Exp Physiol. 2013 Jun; 98(6):1102-14. Porszasz J, Rambod M, van der Vaart H, Rossiter HB, Ma S, Kiledjian R, Casaburi R. PMID: 23335005.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    52. On-off asymmetries in oxygen consumption kinetics of single Xenopus laevis skeletal muscle fibres suggest higher-order control. J Physiol. 2013 Feb 01; 591(3):731-44. Wüst RC, van der Laarse WJ, Rossiter HB. PMID: 23165768.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    53. Heavy and moderate interval exercise training alters low-flow-mediated constriction but does not increase circulating progenitor cells in healthy humans. Exp Physiol. 2012 Mar; 97(3):375-85. Rakobowchuk M, Harris E, Taylor A, Baliga V, Cubbon RM, Rossiter HB, Birch KM. PMID: 22179420.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCellsCTClinical Trials
    54. Regional skeletal muscle remodeling and mitochondrial dysfunction in right ventricular heart failure. . 2012 Jan; 302(2):H402-11. Wüst RC, Myers DS, Stones R, Benoist D, Robinson PA, Boyle JP, Peers C, White E, Rossiter HB. PMID: 22037189.
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    55. The intramuscular contribution to the slow oxygen uptake kinetics during exercise in chronic heart failure is related to the severity of the condition. J Appl Physiol (1985). 2012 Feb; 112(3):378-87. Bowen TS, Cannon DT, Murgatroyd SR, Birch KM, Witte KK, Rossiter HB. PMID: 22033530.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    56. Oxygen uptake kinetics during incremental- and decremental-ramp cycle ergometry. J Sports Sci Med. 2011; 10(3):584-9. Ozyener F, Rossiter HB, Ward SA, Whipp BJ. PMID: 24150637.
      View in: PubMed   Mentions: 6     Fields:    
    57. A raised metabolic rate slows pulmonary O(2) uptake kinetics on transition to moderate-intensity exercise in humans independently of work rate. Exp Physiol. 2011 Oct; 96(10):1049-61. Bowen TS, Murgatroyd SR, Cannon DT, Cuff TJ, Lainey AF, Marjerrison AD, Spencer MD, Benson AP, Paterson DH, Kowalchuk JM, Rossiter HB. PMID: 21705403.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    58. Kinetic control of oxygen consumption during contractions in self-perfused skeletal muscle. J Physiol. 2011 Aug 15; 589(Pt 16):3995-4009. Wüst RC, Grassi B, Hogan MC, Howlett RA, Gladden LB, Rossiter HB. PMID: 21690197.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    59. Pulmonary O2 uptake kinetics as a determinant of high-intensity exercise tolerance in humans. J Appl Physiol (1985). 2011 Jun; 110(6):1598-606. Murgatroyd SR, Ferguson C, Ward SA, Whipp BJ, Rossiter HB. PMID: 21415174.
      View in: PubMed   Mentions: 44     Fields:    Translation:Humans
    60. Skeletal muscle fatigue precedes the slow component of oxygen uptake kinetics during exercise in humans. J Physiol. 2011 Feb 01; 589(Pt 3):727-39. Cannon DT, White AC, Andriano MF, Kolkhorst FW, Rossiter HB. PMID: 21135050.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCTClinical Trials
    61. Faster O2 uptake kinetics in canine skeletal muscle in situ after acute creatine kinase inhibition. J Physiol. 2011 Jan 01; 589(Pt 1):221-33. Grassi B, Rossiter HB, Hogan MC, Howlett RA, Harris JE, Goodwin ML, Dobson JL, Gladden LB. PMID: 21059760.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    62. Clarifying the equation for modeling of VO2 kinetics above the lactate threshold. J Appl Physiol (1985). 2010 Oct; 109(4):1283-4. Ma S, Rossiter HB, Barstow TJ, Casaburi R, Porszasz J. PMID: 20940444.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    63. Comments on point: counterpoint: the kinetics of oxygen uptake during muscular exercise do/do not manifest time-delayed phase. Time-delayed phases in pulmonary Vo2: a control systems view. J Appl Physiol (1985). 2009 11; 107(5):1674. Rossiter HB. PMID: 19899212.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    64. Hyperventilation-induced hypocapnic alkalosis slows the adaptation of pulmonary O2 uptake during the transition to moderate-intensity exercise. J Physiol. 2007 Aug 15; 583(Pt 1):351-64. Chin LM, Leigh RJ, Heigenhauser GJ, Rossiter HB, Paterson DH, Kowalchuk JM. PMID: 17584832.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    65. Thigh muscle activation distribution and pulmonary VO2 kinetics during moderate, heavy, and very heavy intensity cycling exercise in humans. . 2007 Aug; 293(2):R812-20. Endo MY, Kobayakawa M, Kinugasa R, Kuno S, Akima H, Rossiter HB, Miura A, Fukuba Y. PMID: 17459915.
      View in: PubMed   Mentions:
    66. Kinetics of pulmonary VO2 and femoral artery blood flow and their relationship during repeated bouts of heavy exercise. Eur J Appl Physiol. 2005 Dec; 95(5-6):418-30. Endo M, Okada Y, Rossiter HB, Ooue A, Miura A, Koga S, Fukuba Y. PMID: 16193337.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    67. Facial cooling-induced bradycardia does not slow pulmonary V.O2 kinetics at the onset of high-intensity exercise. J Appl Physiol (1985). 2003 Oct; 95(4):1623-31. Endo M, Tauchi S, Hayashi N, Koga S, Rossiter HB, Fukuba Y. PMID: 12844498.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    68. The effect of resistive breathing on leg muscle oxygenation using near-infrared spectroscopy during exercise in men. Exp Physiol. 2002 Sep; 87(5):601-11. Kowalchuk JM, Rossiter HB, Ward SA, Whipp BJ. PMID: 12481935.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
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