Nicholas Gregory Jendzjowsky

Title(s)Assistant Professor-in-Residence, Medicine
ORCID ORCID Icon0000-0002-4342-1839 Additional info
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    Collapse Education and Training
    University of Alberta, Edmonton Alberta CanadaPh.D.07/2013Vascular Physiology
    University of Alberta, Edmonton Alberta CanadaMS.c.09/2007Cardiovascular Physiology
    University of Alberta, Edmonton Alberta CanadaBS.c.05/2005Kinesiology
    Collapse Awards and Honors
    University of Calgary2020David Proud Award for Research Excellence

    Collapse Overview 
    Collapse Overview
    Dr. Jendzjowsky’s laboratory is part of a collaborative effort investigating how the sensory neurons form a part of the immune landscape to sense pathogenic infiltration and influence the immune system to mitigate disease. His multidisciplinary research program incorporates immunology, neuroscience and respiratory physiology, investigating bacterial infection (pneumonia) and allergic (asthma) diseases in the lung.
    The lung is tasked to be the organ where oxygen is taken into the body and bloodstream. However, this unique ability renders this organ susceptible to pathogenic infiltration and allergic disease. The focus on pulmonary bacterial pathogenic infiltration is of the utmost importance, given the increasing strains of multi-drug resistant bacteria. In the same vein, asthma is ever-increasing in children causing a severe impact on the quality of life.
    The Jendzjowsky Laboratory takes an innovative approach to investigate neural reflexes and how they form a first line of defence alongside the immune system to mitigate harmful pathogens and allergens to improve health outcomes.

    Collapse Research 
    Collapse Research Activities and Funding
    Unravelling lung interoception and its functional consequence in the developing ovine lung
    NIH/NCCIH R01AT011691Sep 1, 2022 - Aug 30, 2027
    Role: Co-Investigator
    Description: This project will gather crucial foundational information to advance our understanding of pulmonary diseases that originate during fetal and newborn life.
    Investigating neural mechanisms of asthma induced by perinatal E-cigarette smoke exposure
    UCOP TRDRP T32KT478Jul 1, 2022 - Jun 30, 2025
    Role: Primary Investigator
    Description: The major goals of this project is to investigate how e-cigarette sensitize neural clusters to stimulate airway hypersensitivity and induce lifelong asthma when exposed during fetal development.
    Investigating neural origins of hypertension by perinatal nicotine exposure
    UCOP TRDRP T32IP4707Jul 1, 2022 - Jun 30, 2024
    Role: Primary Investigator
    Description: The major goals of this project is to investigate development of cardiovascular disease, specifically hypertension, induced by fetal and childhood exposure to nicotine.
    Unraveling transcriptomic and functional changes to immune sensing neuronal ganglia in response to allergy and bacteria
    NIH/NIAID R21AI159221May 1, 2022 - Apr 30, 2024
    Role: Primary Investigator
    Description: The major goals of this project are to discern phenotypic and physiologic differences to neuronal ganglia posed by systemic allergy and bacteria.
    NIH/NCATS UL1TR001881Sep 1, 2021 - Jul 1, 2022
    Role: Co-Investigator
    Description: This project explores the hypothesis that complementary neuroendocrine-neuron clusters become sensitized with allergic asthma and exacerbate asthmatic inflammation and reflex mediated bronchoconstriction.
    A novel neuronal mechanism of asthmatic bronchoconstriction
    Francis Family Foundation Jul 1, 2019 - Jun 30, 2022
    Role: Primary Investigator
    Description: This is a fellowship award for investigators in pulmonary research. The proposed project is to determine a novel neuronal mechanism of airway hyperresponsiveness.

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hemorrhage at high altitude: impact of sustained hypobaric hypoxia on cerebral blood flow, tissue oxygenation, and tolerance to simulated hemorrhage in humans. Eur J Appl Physiol. 2024 Mar 15. Rosenberg AJ, Anderson GK, McKeefer HJ, Bird J, Pentz B, Byman BRM, Jendzjowsky N, Wilson RJ, Day TA, Rickards CA. PMID: 38489034.
      View in: PubMed   Mentions:    Fields:    
    2. Sensory neurons regulate stimulus-dependent humoral immunity. bioRxiv. 2024 Feb 05. Aguilar D, Zhu F, Millet A, Millet N, Germano P, Pisegna J, Doherty TA, Swidergall M, Jendzjowsky N. PMID: 38260709; PMCID: PMC10802321.
      View in: PubMed   Mentions:
    3. Sex-related Differences in Loop Gain during High-Altitude Sleep-disordered Breathing. Ann Am Thorac Soc. 2023 08; 20(8):1192-1200. Bird JD, Sands SA, Alex RM, Shing CLH, Shafer BM, Jendzjowsky NG, Wilson RJA, Day TA, Foster GE. PMID: 37000675; PMCID: PMC10405604.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    4. Pathogen recognition by sensory neurons: hypotheses on the specificity of sensory neuron signaling. Front Immunol. 2023; 14:1184000. Millet A, Jendzjowsky N. PMID: 37207232; PMCID: PMC10189129.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    5. Editorial: Mitochondrial sensitivity of sensory neurons controlling breathing. Front Physiol. 2022; 13:1068341. Jendzjowsky N, Coney AM. PMID: 36388093; PMCID: PMC9650655.
      View in: PubMed   Mentions:
    6. IL-23 signaling prevents ferroptosis-driven renal immunopathology during candidiasis. Nat Commun. 2022 09 22; 13(1):5545. Millet N, Solis NV, Aguilar D, Lionakis MS, Wheeler RT, Jendzjowsky N, Swidergall M. PMID: 36138043; PMCID: PMC9500047.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    7. Functional optical coherence tomography at altitude: retinal microvascular perfusion and retinal thickness at 3,800 meters. J Appl Physiol (1985). 2022 09 01; 133(3):534-545. Baker J, Safarzadeh MA, Incognito AV, Jendzjowsky NG, Foster GE, Bird JD, Raj SR, Day TA, Rickards CA, Zubieta-DeUrioste N, Alim U, Wilson RJA. PMID: 35771223.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    8. Neuroanatomical and neurophysiological evidence of pulmonary nociceptor and carotid chemoreceptor convergence in the nucleus tractus solitarius and nucleus ambiguus. J Neurophysiol. 2022 06 01; 127(6):1511-1518. Zyuzin J, Jendzjowsky N. PMID: 35443145; PMCID: PMC9142158.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    9. Long-term modulation of airway remodelling in severe asthma following bronchial thermoplasty. Eur Respir J. 2022 01; 59(1). Jendzjowsky N, Laing A, Malig M, Matyas J, de Heuvel E, Dumonceaux C, Dumoulin E, Tremblay A, Leigh R, Chee A, Kelly MM. PMID: 34049950.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    10. Duration at high altitude influences the onset of arrhythmogenesis during apnea. Eur J Appl Physiol. 2022 Feb; 122(2):475-487. Berthelsen LF, van Diepen S, Steele AR, Vanden Berg ER, Bird J, Thrall S, Skalk A, Byman B, Pentz B, Wilson RJA, Jendzjowsky NG, Day TA, Steinback CD. PMID: 34800158.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Interleukin-4 Programmed Macrophages Suppress Colitis and Do Not Enhance Infectious-Colitis, Inflammation-Associated Colon Cancer or Airway Hypersensitivity. Front Immunol. 2021; 12:744738. Callejas BE, Blyth GAD, Jendzjowsky N, Wang A, Babbar A, Koro K, Wilson RJA, Kelly MM, Cobo ER, McKay DM. PMID: 34691050; PMCID: PMC8527087.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    12. Identifying a Heart Rate Recovery Criterion After a 6-Minute Walk Test in COPD. Int J Chron Obstruct Pulmon Dis. 2021; 16:2545-2560. Zhao D, Abbasi A, Casaburi R, Adami A, Tiller NB, Yuan W, Yee C, Jendzjowsky NG, MacDonald DM, Kunisaki KM, Stringer WW, Porszasz J, Make BJ, Bowler RP, Rossiter HB, COPDGene Investigators. PMID: 34511898; PMCID: PMC8427685.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    13. Asthmatic allergen inhalation sensitises carotid bodies to lysophosphatidic acid. J Neuroinflammation. 2021 Aug 31; 18(1):191. Jendzjowsky NG, Roy A, Wilson RJA. PMID: 34465362; PMCID: PMC8408927.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    14. Severity of central sleep apnea does not affect sleeping oxygen saturation during ascent to high altitude. J Appl Physiol (1985). 2021 11 01; 131(5):1432-1443. Bird JD, Kalker A, Rimke AN, Chan JS, Chan G, Saran G, Jendzjowsky NG, Wilson RJA, Brutsaert TD, Sherpa MT, Day TA. PMID: 34435507.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    15. The effects of acute incremental hypocapnia on the magnitude of neurovascular coupling in healthy participants. Physiol Rep. 2021 08; 9(15):e14952. Bader TJ, Leacy JK, Keough JRG, Ciorogariu-Ivan AM, Donald JR, Marullo AL, O'Halloran KD, Jendzjowsky NG, Wilson RJA, Day TA. PMID: 34350726; PMCID: PMC8339533.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    16. Peaks and valleys: oscillatory cerebral blood flow at high altitude protects cerebral tissue oxygenation. Physiol Meas. 2021 06 29; 42(6). Anderson GK, Rosenberg AJ, Barnes HJ, Bird J, Pentz B, Byman BRM, Jendzjowsky N, Wilson RJA, Day TA, Rickards CA. PMID: 34038879.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    17. Time course and magnitude of ventilatory and renal acid-base acclimatization following rapid ascent to and residence at 3,800 m over nine days. J Appl Physiol (1985). 2021 06 01; 130(6):1705-1715. Bird JD, Leacy JK, Foster GE, Rickards CA, Wilson RJA, O'Halloran KD, Jendzjowsky NG, Pentz BA, Byman BRM, Thrall SF, Skalk AL, Hewitt SA, Steinback CD, Burns D, Ondrus P, Day TA. PMID: 33703943.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    18. PKCε stimulation of TRPV1 orchestrates carotid body responses to asthmakines. J Physiol. 2021 02; 599(4):1335-1354. Jendzjowsky NG, Roy A, Iftinca M, Barioni NO, Kelly MM, Herrington BA, Visser F, Altier C, Wilson RJA. PMID: 33180962; PMCID: PMC7898719.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    19. Intestinal fungi are causally implicated in microbiome assembly and immune development in mice. Nat Commun. 2020 05 22; 11(1):2577. van Tilburg Bernardes E, Pettersen VK, Gutierrez MW, Laforest-Lapointe I, Jendzjowsky NG, Cavin JB, Vicentini FA, Keenan CM, Ramay HR, Samara J, MacNaughton WK, Wilson RJA, Kelly MM, McCoy KD, Sharkey KA, Arrieta MC. PMID: 32444671; PMCID: PMC7244730.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimals
    20. The organization of the sympathetic nervous system: shining new light on historic views. J Physiol. 2019 11; 597(22):5327-5329. Incognito AV, Jendzjowsky NG. PMID: 31535387.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    21. Functional-Optical Coherence Tomography: A Non-invasive Approach to Assess the Sympathetic Nervous System and Intrinsic Vascular Regulation. Front Physiol. 2019; 10:1146. Jendzjowsky NG, Steinback CD, Herman RJ, Tsai WH, Costello FE, Wilson RJA. PMID: 31572206; PMCID: PMC6751282.
      View in: PubMed   Mentions: 12  
    22. The Role of Airway Myofibroblasts in Asthma. Chest. 2019 12; 156(6):1254-1267. Jendzjowsky NG, Kelly MM. PMID: 31472157.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    23. Preventing acute asthmatic symptoms by targeting a neuronal mechanism involving carotid body lysophosphatidic acid receptors. Nat Commun. 2018 10 02; 9(1):4030. Jendzjowsky NG, Roy A, Barioni NO, Kelly MM, Green FHY, Wyatt CN, Pye RL, Tenorio-Lopes L, Wilson RJA. PMID: 30279412; PMCID: PMC6168495.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    24. Hindlimb unweighting does not alter vasoconstrictor responsiveness and nitric oxide-mediated inhibition of sympathetic vasoconstriction. J Physiol. 2015 May 01; 593(9):2213-24. Just TP, Jendzjowsky NG, DeLorey DS. PMID: 25752721; PMCID: PMC4422573.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    25. Acute tetrahydrobiopterin supplementation attenuates sympathetic vasoconstrictor responsiveness in resting and contracting skeletal muscle of healthy rats. Physiol Rep. 2014 Oct 01; 2(10). Jendzjowsky NG, Just TP, Jones KE, DeLorey DS. PMID: 25318748; PMCID: PMC4254091.
      View in: PubMed   Mentions: 4     Fields:    
    26. Exercise training augments neuronal nitric oxide synthase-mediated inhibition of sympathetic vasoconstriction in contracting skeletal muscle of rats. J Physiol. 2014 Nov 01; 592(21):4789-802. Jendzjowsky NG, Just TP, DeLorey DS. PMID: 25194041; PMCID: PMC4253477.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    27. Short-term exercise training augments 2-adrenoreceptor-mediated sympathetic vasoconstriction in resting and contracting skeletal muscle. J Physiol. 2013 Oct 15; 591(20):5221-33. Jendzjowsky NG, DeLorey DS. PMID: 23940382; PMCID: PMC3810820.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    28. Role of neuronal nitric oxide in the inhibition of sympathetic vasoconstriction in resting and contracting skeletal muscle of healthy rats. J Appl Physiol (1985). 2013 Jul 01; 115(1):97-106. Jendzjowsky NG, DeLorey DS. PMID: 23640592.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    29. Acute superoxide scavenging reduces sympathetic vasoconstrictor responsiveness in short-term exercise-trained rats. J Appl Physiol (1985). 2013 Jun; 114(11):1511-8. Jendzjowsky NG, Delorey DS. PMID: 23558386.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    30. Short-term exercise training enhances functional sympatholysis through a nitric oxide-dependent mechanism. J Physiol. 2013 Mar 15; 591(6):1535-49. Jendzjowsky NG, Delorey DS. PMID: 23297301; PMCID: PMC3607171.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    31. Short-term exercise training augments sympathetic vasoconstrictor responsiveness and endothelium-dependent vasodilation in resting skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2012 Aug 01; 303(3):R332-9. Jendzjowsky NG, DeLorey DS. PMID: 22696575.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    32. A prospective evaluation of non-interval- and interval-based exercise training progressions in rodents. Appl Physiol Nutr Metab. 2011 Oct; 36(5):723-9. Jendzjowsky NG, DeLorey DS. PMID: 21999294.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    33. Using Telehealth technology to deliver pulmonary rehabilitation in chronic obstructive pulmonary disease patients. Can Respir J. 2011 Jul-Aug; 18(4):216-20. Stickland M, Jourdain T, Wong EY, Rodgers WM, Jendzjowsky NG, Macdonald GF. PMID: 22059179; PMCID: PMC3205102.
      View in: PubMed   Mentions: 50     Fields:    Translation:Humans
    34. Pulmonary oxygen uptake and heart rate kinetics during the six-minute walk test in transplant recipients. Transplantation. 2008 Jan 15; 85(1):29-35. Tomczak CR, Warburton DE, Riess KJ, Jendzjowsky NG, Esch BT, Liang Y, Haennel RG, Haykowsky MJ. PMID: 18192908.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    35. A prediction model for estimating pulmonary oxygen uptake during the 6-minute walk test in organ transplant recipients. Transplant Proc. 2007 Dec; 39(10):3313-6. Tomczak CR, Warburton DE, Riess KJ, Jendzjowsky NG, Liang Y, Bhambhani Y, Haennel RG, Haykowsky MJ. PMID: 18089378.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    36. Impaired pulmonary oxygen uptake kinetics and reduced peak aerobic power during small muscle mass exercise in heart transplant recipients. J Appl Physiol (1985). 2007 Nov; 103(5):1722-7. Jendzjowsky NG, Tomczak CR, Lawrance R, Taylor DA, Tymchak WJ, Riess KJ, Warburton DE, Haykowsky MJ. PMID: 17717113.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    37. Relation of etiology of heart failure (ischemic versus nonischemic) before transplantation to delayed pulmonary oxygen uptake kinetics after heart transplantation. Am J Cardiol. 2007 Jun 15; 99(12):1745-9. Tomczak CR, Jendzjowsky NG, Riess KJ, Tymchak W, Kim D, Haennel R, Haykowsky MJ. PMID: 17560887.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
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