Marc Swidergall

Title(s)Assistant Professor-in-Residence, Medicine
SchoolMedicine
ORCID ORCID Icon0000-0002-5261-6267 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Heinrich Heine University , Dusseldorf, GermanyB.Sc.08/2010Biology
    Heinrich Heine University, Dusseldorf, GermanyM.Sc.07/2012Biology
    Heinrich Heine University , Dusseldorf, GermanyPh.D.06/2015Molecular Mycology
    Collapse Awards and Honors
    MMSA2023Thomas J. Walsh Young Investigator Award
    The American Association of Immunologists2021Careers in Immunology Fellowship
    German Society for Hygiene and Microbiology2014Young Investigator Award

    Collapse Overview 
    Collapse Overview
    Dr. Swidergall focuses on cellular and molecular factors that regulate the immune response against mucosal and invasive fungal infections. His goal is to develop a detailed mechanistic understanding of the molecular and cellular basis of innate and adaptive immunity against fungal pathogens with an aim to devise novel strategies to supplement the current antifungal drug treatment.

    Collapse Research 
    Collapse Research Activities and Funding
    Epigenomic mechanisms & STAT networks in persistent candidemia
    NIH U19AI172713Aug 10, 2023 - May 31, 2028
    Role: Co-PI
    Oral commensal fungi and structural immunity
    NIH 1R01DE031382Jul 1, 2022 - May 31, 2027
    Role: Principal Investigator
    Novel Candida albicans host receptors during infection and immune response
    NIH R00DE026856Sep 1, 2019 - Aug 31, 2022
    Role: Principal Investigator
    Novel Candida albicans host receptors during infection and immune response
    NIH K99DE026856Sep 18, 2017 - Aug 31, 2019
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Featured Content 
    Collapse Twitter

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Sensory neurons regulate stimulus-dependent humoral immunity in mouse models of bacterial infection and asthma. Nat Commun. 2024 Oct 16; 15(1):8914. Aguilar D, Zhu F, Millet A, Millet N, Germano P, Pisegna J, Akbari O, Doherty TA, Swidergall M, Jendzjowsky N. PMID: 39414787; PMCID: PMC11484968.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    2. Synergistic cross-kingdom host cell damage between Candida albicans and Enterococcus faecalis. bioRxiv. 2024 Sep 14. Kapitan M, Niemiec MJ, Millet N, Brandt P, Chowdhury MEK, Czapka A, Abdissa K, Hoffmann F, Lange A, Veleba M, Nietzsche S, Mosig AS, Löffler B, Marquet M, Makarewicz O, Kline KA, Vylkova S, Swidergall M, Jacobsen ID. PMID: 39314435; PMCID: PMC11419042.
      View in: PubMed   Mentions:
    3. Non-canonical IL-22 receptor signaling remodels the mucosal barrier during fungal immunosurveillance. bioRxiv. 2024 Sep 13. Millet N, Sekar J, Solis NV, Millet A, Aggor FEY, Wildeman A, Lionakis MS, Gaffen SL, Jendzjowsky N, Filler SG, Swidergall M. PMID: 39314368; PMCID: PMC11419061.
      View in: PubMed   Mentions:
    4. Sensory neurons regulate stimulus-dependent humoral immunity. bioRxiv. 2024 Aug 13. Aguilar D, Zhu F, Millet A, Millet N, Germano P, Pisegna J, Akbari O, Doherty TA, Swidergall M, Jendzjowsky N. PMID: 38260709; PMCID: PMC10802321.
      View in: PubMed   Mentions:
    5. The Role of Interferon-γ in Autoimmune Polyendocrine Syndrome Type 1. N Engl J Med. 2024 May 30; 390(20):1873-1884. Oikonomou V, Smith G, Constantine GM, Schmitt MM, Ferré EMN, Alejo JC, Riley D, Kumar D, Dos Santos Dias L, Pechacek J, Hadjiyannis Y, Webb T, Seifert BA, Ghosh R, Walkiewicz M, Martin D, Besnard M, Snarr BD, Deljookorani S, Lee CR, DiMaggio T, Barber P, Rosen LB, Cheng A, Rastegar A, de Jesus AA, Stoddard J, Kuehn HS, Break TJ, Kong HH, Castelo-Soccio L, Colton B, Warner BM, Kleiner DE, Quezado MM, Davis JL, Fennelly KP, Olivier KN, Rosenzweig SD, Suffredini AF, Anderson MS, Swidergall M, Guillonneau C, Notarangelo LD, Goldbach-Mansky R, Neth O, Monserrat-Garcia MT, Valverde-Fernandez J, Lucena JM, Gomez-Gila AL, Garcia Rojas A, Seppänen MRJ, Lohi J, Hero M, Laakso S, Klemetti P, Lundberg V, Ekwall O, Olbrich P, Winer KK, Afzali B, Moutsopoulos NM, Holland SM, Heller T, Pittaluga S, Lionakis MS. PMID: 38810185; PMCID: PMC11323209.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    6. Candida albicans stimulates formation of a multi-receptor complex that mediates epithelial cell invasion during oropharyngeal infection. PLoS Pathog. 2023 08; 19(8):e1011579. Phan QT, Solis NV, Cravener MV, Swidergall M, Lin J, Huang MY, Liu H, Singh S, Ibrahim AS, Mazzone M, Mitchell AP, Filler SG. PMID: 37611070; PMCID: PMC10479894.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    7. Candida albicans stimulates the formation of a multi-receptor complex that mediates epithelial cell invasion during oropharyngeal infection. bioRxiv. 2023 Feb 23. Phan QT, Solis NV, Cravener MV, Swidergall M, Lin J, Huang MY, Liu H, Singh S, Ibrahim AS, Mazzone M, Mitchell AP, Filler SG. PMID: 36865306; PMCID: PMC9980113.
      View in: PubMed   Mentions:
    8. IL-23 signaling prevents ferroptosis-driven renal immunopathology during candidiasis. Nat Commun. 2022 09 22; 13(1):5545. Millet N, Solis NV, Aguilar D, Lionakis MS, Wheeler RT, Jendzjowsky N, Swidergall M. PMID: 36138043; PMCID: PMC9500047.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    9. Serum bridging molecules drive candidal invasion of human but not mouse endothelial cells. PLoS Pathog. 2022 07; 18(7):e1010681. Phan QT, Solis NV, Lin J, Swidergall M, Singh S, Liu H, Sheppard DC, Ibrahim AS, Mitchell AP, Filler SG. PMID: 35797411; PMCID: PMC9295963.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    10. Immunosurveillance of Candida albicans commensalism by the adaptive immune system. Mucosal Immunol. 2022 05; 15(5):829-836. Swidergall M, LeibundGut-Landmann S. PMID: 35778599; PMCID: PMC9385492.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    11. Editorial: Immunological Memory to Fungal Infections and Vaccine Development. Front Immunol. 2022; 13:880037. Nicola AM, Desai JV, Swidergall M, Shey M, Dambuza IM. PMID: 35572566; PMCID: PMC9094483.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. Control of β-glucan exposure by the endo-1,3-glucanase Eng1 in Candida albicans modulates virulence. PLoS Pathog. 2022 01; 18(1):e1010192. Yang M, Solis NV, Marshall M, Garleb R, Zhou T, Wang D, Swidergall M, Pearlman E, Filler SG, Liu H. PMID: 34995333; PMCID: PMC8775328.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    13. The Globular C1q Receptor Is Required for Epidermal Growth Factor Receptor Signaling during Candida albicans Infection. mBio. 2021 12 21; 12(6):e0271621. Phan QT, Lin J, Solis NV, Eng M, Swidergall M, Wang F, Li S, Gaffen SL, Chou TF, Filler SG. PMID: 34724825; PMCID: PMC8561387.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    14. Response to Comments on "Aberrant type 1 immunity drives susceptibility to mucosal fungal infections". Science. 2021 Sep 17; 373(6561):eabi8835. Break TJ, Oikonomou V, Dutzan N, Desai JV, Swidergall M, Freiwald T, Chauss D, Harrison OJ, Alejo J, Williams DW, Pittaluga S, Lee CR, Bouladoux N, Swamydas M, Hoffman KW, Greenwell-Wild T, Bruno VM, Rosen LB, Lwin W, Renteria A, Pontejo SM, Shannon JP, Myles IA, Olbrich P, Ferré EMN, Schmitt M, Martin D, Genomics and Computational Biology Core16, Barber DL, Solis NV, Notarangelo LD, Serreze DV, Matsumoto M, Hickman HD, Murphy PM, Anderson MS, Lim JK, Holland SM, Filler SG, Afzali B, Belkaid Y, Moutsopoulos NM, Lionakis MS. PMID: 34529475; PMCID: PMC10120387.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    15. Rapid proliferation due to better metabolic adaptation results in full virulence of a filament-deficient Candida albicans strain. Nat Commun. 2021 06 23; 12(1):3899. Dunker C, Polke M, Schulze-Richter B, Schubert K, Rudolphi S, Gressler AE, Pawlik T, Prada Salcedo JP, Niemiec MJ, Slesiona-Künzel S, Swidergall M, Martin R, Dandekar T, Jacobsen ID. PMID: 34162849; PMCID: PMC8222383.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    16. Activation of EphA2-EGFR signaling in oral epithelial cells by Candida albicans virulence factors. PLoS Pathog. 2021 01; 17(1):e1009221. Swidergall M, Solis NV, Millet N, Huang MY, Lin J, Phan QT, Lazarus MD, Wang Z, Yeaman MR, Mitchell AP, Filler SG. PMID: 33471869; PMCID: PMC7850503.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    17. Mucoricin is a ricin-like toxin that is critical for the pathogenesis of mucormycosis. Nat Microbiol. 2021 03; 6(3):313-326. Soliman SSM, Baldin C, Gu Y, Singh S, Gebremariam T, Swidergall M, Alqarihi A, Youssef EG, Alkhazraji S, Pikoulas A, Perske C, Venkataramani V, Rich A, Bruno VM, Hotopp JD, Mantis NJ, Edwards JE, Filler SG, Chamilos G, Vitetta ES, Ibrahim AS. PMID: 33462434; PMCID: PMC7914224.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    18. Aberrant type 1 immunity drives susceptibility to mucosal fungal infections. Science. 2021 01 15; 371(6526). Break TJ, Oikonomou V, Dutzan N, Desai JV, Swidergall M, Freiwald T, Chauss D, Harrison OJ, Alejo J, Williams DW, Pittaluga S, Lee CR, Bouladoux N, Swamydas M, Hoffman KW, Greenwell-Wild T, Bruno VM, Rosen LB, Lwin W, Renteria A, Pontejo SM, Shannon JP, Myles IA, Olbrich P, Ferré EMN, Schmitt M, Martin D, Genomics and Computational Biology Core, Barber DL, Solis NV, Notarangelo LD, Serreze DV, Matsumoto M, Hickman HD, Murphy PM, Anderson MS, Lim JK, Holland SM, Filler SG, Afzali B, Belkaid Y, Moutsopoulos NM, Lionakis MS. PMID: 33446526; PMCID: PMC8326743.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    19. Mucosal IgA Prevents Commensal Candida albicans Dysbiosis in the Oral Cavity. Front Immunol. 2020; 11:555363. Millet N, Solis NV, Swidergall M. PMID: 33193324; PMCID: PMC7642201.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    20. Interleukin-26 activates macrophages and facilitates killing of Mycobacterium tuberculosis. Sci Rep. 2020 10 14; 10(1):17178. Hawerkamp HC, van Geelen L, Korte J, Di Domizio J, Swidergall M, Momin AA, Guzmán-Vega FJ, Arold ST, Ernst J, Gilliet M, Kalscheuer R, Homey B, Meller S. PMID: 33057074; PMCID: PMC7558018.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    21. GRP78 and Integrins Play Different Roles in Host Cell Invasion during Mucormycosis. mBio. 2020 06 02; 11(3). Alqarihi A, Gebremariam T, Gu Y, Swidergall M, Alkhazraji S, Soliman SSM, Bruno VM, Edwards JE, Filler SG, Uppuluri P, Ibrahim AS. PMID: 32487760; PMCID: PMC7267888.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    22. Candidalysin Is Required for Neutrophil Recruitment and Virulence During Systemic Candida albicans Infection. J Infect Dis. 2019 09 26; 220(9):1477-1488. Swidergall M, Khalaji M, Solis NV, Moyes DL, Drummond RA, Hube B, Lionakis MS, Murdoch C, Filler SG, Naglik JR. PMID: 31401652; PMCID: PMC6761979.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    23. EphA2 Is a Neutrophil Receptor for Candida albicans that Stimulates Antifungal Activity during Oropharyngeal Infection. Cell Rep. 2019 07 09; 28(2):423-433.e5. Swidergall M, Solis NV, Wang Z, Phan QT, Marshall ME, Lionakis MS, Pearlman E, Filler SG. PMID: 31291578; PMCID: PMC6638578.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    24. Selection of Candida albicans trisomy during oropharyngeal infection results in a commensal-like phenotype. PLoS Genet. 2019 05; 15(5):e1008137. Forche A, Solis NV, Swidergall M, Thomas R, Guyer A, Beach A, Cromie GA, Le GT, Lowell E, Pavelka N, Berman J, Dudley AM, Selmecki A, Filler SG. PMID: 31091232; PMCID: PMC6538192.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    25. Candida albicans at Host Barrier Sites: Pattern Recognition Receptors and Beyond. Pathogens. 2019 Mar 25; 8(1). Swidergall M. PMID: 30934602; PMCID: PMC6471378.
      View in: PubMed   Mentions: 20  
    26. Author Correction: EphA2 is an epithelial cell pattern recognition receptor for fungal β-glucans. Nat Microbiol. 2018 Sep; 3(9):1074. Swidergall M, Solis NV, Lionakis MS, Filler SG. PMID: 29895959; PMCID: PMC8091941.
      View in: PubMed   Mentions: 2     Fields:    
    27. Inhibition of EGFR Signaling Protects from Mucormycosis. mBio. 2018 08 14; 9(4). Watkins TN, Gebremariam T, Swidergall M, Shetty AC, Graf KT, Alqarihi A, Alkhazraji S, Alsaadi AI, Edwards VL, Filler SG, Ibrahim AS, Bruno VM. PMID: 30108171; PMCID: PMC6094478.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    28. Candida albicans White-Opaque Switching Influences Virulence but Not Mating during Oropharyngeal Candidiasis. Infect Immun. 2018 06; 86(6). Solis NV, Park YN, Swidergall M, Daniels KJ, Filler SG, Soll DR. PMID: 29581190; PMCID: PMC5964503.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    29. The Hyr1 protein from the fungus Candida albicans is a cross kingdom immunotherapeutic target for Acinetobacter bacterial infection. PLoS Pathog. 2018 05; 14(5):e1007056. Uppuluri P, Lin L, Alqarihi A, Luo G, Youssef EG, Alkhazraji S, Yount NY, Ibrahim BA, Bolaris MA, Edwards JE, Swidergall M, Filler SG, Yeaman MR, Ibrahim AS. PMID: 29746596; PMCID: PMC5963808.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCellsPHPublic Health
    30. Publisher Correction: EphA2 is an epithelial cell pattern recognition receptor for fungal β-glucans. Nat Microbiol. 2018 Mar; 3(3):387. Swidergall M, Solis NV, Lionakis MS, Filler SG. PMID: 29440749.
      View in: PubMed   Mentions: 1     Fields:    
    31. EphA2 is an epithelial cell pattern recognition receptor for fungal β-glucans. Nat Microbiol. 2018 Jan; 3(1):53-61. Swidergall M, Solis NV, Lionakis MS, Filler SG. PMID: 29133884; PMCID: PMC5736406.
      View in: PubMed   Mentions: 97     Fields:    Translation:AnimalsCells
    32. Innate Immunity to Mucosal Candida Infections. J Fungi (Basel). 2017 Oct 31; 3(4). Verma A, Gaffen SL, Swidergall M. PMID: 29371576; PMCID: PMC5753162.
      View in: PubMed   Mentions: 29  
    33. The Aryl Hydrocarbon Receptor Governs Epithelial Cell Invasion during Oropharyngeal Candidiasis. mBio. 2017 03 21; 8(2). Solis NV, Swidergall M, Bruno VM, Gaffen SL, Filler SG. PMID: 28325761; PMCID: PMC5362030.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    34. Oropharyngeal Candidiasis: Fungal Invasion and Epithelial Cell Responses. PLoS Pathog. 2017 01; 13(1):e1006056. Swidergall M, Filler SG. PMID: 28081240; PMCID: PMC5230744.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    35. Aspergillus fumigatus CalA binds to integrin α5β1 and mediates host cell invasion. Nat Microbiol. 2016 Nov 14; 2:16211. Liu H, Lee MJ, Solis NV, Phan QT, Swidergall M, Ralph B, Ibrahim AS, Sheppard DC, Filler SG. PMID: 27841851; PMCID: PMC5495140.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    36. Candida albicans responds to glycostructure damage by Ace2-mediated feedback regulation of Cek1 signaling. Mol Microbiol. 2016 12; 102(5):827-849. van Wijlick L, Swidergall M, Brandt P, Ernst JF. PMID: 27589033.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    37. Signaling domains of mucin Msb2 in Candida albicans. Eukaryot Cell. 2015 Apr; 14(4):359-70. Swidergall M, van Wijlick L, Ernst JF. PMID: 25636320; PMCID: PMC4385809.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    38. Interplay between Candida albicans and the antimicrobial peptide armory. Eukaryot Cell. 2014 Aug; 13(8):950-7. Swidergall M, Ernst JF. PMID: 24951441; PMCID: PMC4135787.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimals
    39. Candida albicans mucin Msb2 is a broad-range protectant against antimicrobial peptides. Antimicrob Agents Chemother. 2013 Aug; 57(8):3917-22. Swidergall M, Ernst AM, Ernst JF. PMID: 23733470; PMCID: PMC3719696.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    40. Msb2 shedding protects Candida albicans against antimicrobial peptides. PLoS Pathog. 2012 Feb; 8(2):e1002501. Szafranski-Schneider E, Swidergall M, Cottier F, Tielker D, Román E, Pla J, Ernst JF. PMID: 22319443; PMCID: PMC3271078.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
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